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HTLV Myelopathy

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https://www.readbyqxmd.com/read/28716148/prevalence-of-plasma-autoantibody-against-cancer-testis-antigen-ny-eso-1-in-htlv-1-infected-individuals-with-different-clinical-status
#1
Yasuo Shiohama, Tadasuke Naito, Toshio Matsuzaki, Reiko Tanaka, Takeaki Tomoyose, Hiroshi Takashima, Takuya Fukushima, Yuetsu Tanaka, Mineki Saito
BACKGROUND: Detection of specific immune responses against cancer/testis antigen NY-ESO-1 was recently reported in patients with adult T-cell leukemia/lymphoma (ATL) and human T-cell leukemia virus type 1 (HTLV-1)-infected asymptomatic carriers (ACs). However, the relationship of the responses with the HTLV-1 proviral load (PVL) and the levels of viral gene expression remain unclear. FINDINGS: We measured plasma levels of autoantibodies to NY-ESO-1 immunogenic tumor antigen in HTLV-1-infected individuals with different clinical status, and in healthy controls...
July 17, 2017: Virology Journal
https://www.readbyqxmd.com/read/28700391/human-t-lymphotropic-virus-type-1-infection-and-disease-in-spain
#2
Carmen de Mendoza, Estrella Caballero, Antonio Aguilera, Silvia Requena, Raúl Ortiz de Lejarazu, María Pirón, Rocío González, Ana Jiménez, Lourdes Roc, Ana Treviño, Rafael Benito, Miriam Fernández-Alonso, Aitziber Aguinaga, Carmen Rodríguez, Juan García-Costa, Lidia Blanco, José M Ramos, Enrique Calderón, José M Eirós, Silvia Sauleda, Pablo Barreiro, Vicente Soriano
: Human T-lymphotropic virus type 1 (HTLV-1) infection is a neglected disease despite roughly 15 million people are chronically infected worldwide. Lifelong less than 10% of carriers develop life-threatening diseases, mostly a subacute myelopathy known as tropical spastic paraparesis (TSP) and a lymphoproliferative disorder named adult T-cell leukemia (ATL). HTLV-1 is efficiently transmitted perinatally (breastfeeding), sexually (more from men to women) and parenterally (transfusions, injection drug user (IDU), and transplants)...
July 31, 2017: AIDS
https://www.readbyqxmd.com/read/28689168/systemic-diseases-in-patients-with-htlv-1-associated-uveitis
#3
Kumiko Nakao, Noriko Abematsu, Taiji Sakamoto
BACKGROUND: Human T-lymphotropic virus type 1 (HTLV-1) carriers may develop severe systemic diseases, such as adult T cell leukaemia (ATL) or HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). This study aims to investigate systemic diseases of HTLV-1 carriers who had developed HTLV-1-associated uveitis (HAU). METHODS: We investigated the occurrence of systemic diseases in 200 patients with HAU by performing a retrospective investigation of their medical records and examining the results of a postal survey...
July 8, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28651832/htlv-1-infection-in-reunion
#4
G Hoarau, B A Gaüzère, H Renard, P Aubry
OBJECTIVES: Although regularly looked for in blood donors, HTLV infections are very rare in Reunion. We aimed to describe HTLV infections locally. PATIENTS AND METHODS: HTLV infections were identified from the database of the Reunion University Hospital administrative database (PMSI) between 2000 and 2016. Diagnosis was performed with HTLV 1/2 enzyme immunoassay test and confirmed by Western blot. RESULTS: We reported three asymptomatic and four symptomatic HTLV infections, including two tropical spastic paraparesis/HTLV-1 associated myelopathies (TSP/HAM) and two adult T-cell leukemia/lymphoma (ATLL), diagnosed between 2000 and 2016...
June 23, 2017: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/28648091/mediators-go-together-high-production-of-cxcl9-cxcl10-ifn-%C3%AE-and-tnf-%C3%AE-in-htlv-1-associated-myelopathy-tropical-spastic-paraparesis
#5
Heytor Victor Pereira da Costa Neco, Vanessa Gabryelle da Silva Teixeira, Ana Carolina Lemos da Trindade, Paula Machado Ribeiro Magalhães, Virgínia Maria Barros de Lorena, Lúcio Roberto Cançado Castellano, Joelma Rodrigues de Souza, Luydson Richardson Vasconcelos, Patrícia Muniz Mendes Freire de Moura, Clarice Neuenschwander Lins de Morais
HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic demyelinating and disabling syndrome caused by human T lymphotropic virus 1 (HTLV-1). Although the pathogenic mechanisms that lead to HAM/TSP outcome have not been elucidated, genetic and immunological factors may be involved in the myelopathy occurrence. This study aimed to compare cytokines, chemokines, and nitric oxide (NO) levels in asymptomatic and HAM/TSP HTLV-1-infected patients. The study group consisted of 21 HAM/TSP and 48 asymptomatic HTLV-1 patients...
July 25, 2017: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/28615198/polymorphic-nature-of-htlv-1-particle-cores-as-revealed-through-characterization-of-a-chronically-infected-cell-line
#6
Morgan E Meissner, Luiza Mendonça, Wei Zhang, Louis M Mansky
Human T-cell leukemia virus type 1 (HTLV-1) is the etiological agent of adult T-cell leukemia (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). HTLV-1 cell-to-cell transmission is dependent on the release of infectious virus particles into the virological synapse. HTLV-1 particle structure is still poorly understood, and previous studies have analyzed viruses produced by transformed lymphocytic cell lines chronically infected with HTLV-1, particularly the MT-2 cell line, which harbors truncated proviruses and expresses aberrant forms of the Gag protein...
June 14, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28608127/downregulation-of-histone-methyltransferase-ehmt2-in-cd4-t-cells-may-protect-htlv-1-infected-individuals-against-ham-tsp-development
#7
Camila Schoueri Colaço, Adriano Reis de Matos, Martha Silva Estrêla, Maurício Cristiano Rocha-Júnior, Kátia Kaori Otaguiri, Evandra Strazza Rodrigues, Osvaldo Massaiti Takayanagui, Dimas Tadeu Covas, Simone Kashima, Fabio Pittella Silva, Rodrigo Haddad
Approximately 5% of human T-cell leukemia virus type 1 (HTLV-1)-infected individuals will develop one of the HTLV-1-related diseases, such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) or adult T-cell leukemia. However, the mechanisms responsible for the appearance of symptoms have not been fully clarified. It is believed that viral factors, host genetic and epigenetic mechanisms are implicated in this process. Studies have shown the involvement of histone methyltransferases in retrovirus infection, but no study observed their expression in HTLV-1-infected patients...
June 12, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28596939/undifferentiated-pleomorphic-sarcoma-and-the-importance-of-considering-the-oncogenic-and-immune-suppressant-role-of-the-human-t-cell-lymphotropic-virus-type-1-a-case-report
#8
Sergio Lupo, Carolina Berini, Camila Cánepa, Eduardo Santini Araujo, Mirna Biglione
INTRODUCTION: Soft-tissue sarcomas account for 0.7% of all malignant tumors, with an incidence rate of 3 per 100,000 persons/year. The undifferentiated pleomorphic sarcoma (UPS) with giant cells, a high grade tumor of soft tissue, is very unusual, especially in young adults before the age of 40. Human T-cell lymphotropic virus type 1 (HTLV-1) is a human retrovirus, classified as group 1 human carcinogens by The International Agency for Research on Cancer, that causes an aggressive malignancy known as adult T-cell lymphoma/leukemia and a progressive chronic inflammatory neurological disease named HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP)...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28582585/early-onset-of-htlv-1-associated-myelopathy-tropical-spastic-paraparesis-ham-tsp-and-adult-t-cell-leukemia-lymphoma-atl-systematic-search-and-review
#9
Pedro D Oliveira, Amanda C Kachimarek, Achiléa L Bittencourt
Human T-cell lymphotropic virus type 1 (HTLV-1) is endemic in some regions and its vertical transmission occurs mainly through breastfeeding. About 10% of carriers develop associated diseases including HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP), adult T-cell leukemia/lymphoma (ATL) and infectious dermatitis associated with HTLV-1 (IDH). We searched for available case reports of early-onset HAM/TSP and ATL to evaluate demographic and disease aspects in infantile-juvenile patients. In the reviewed literature, 27 HAM/TSP and 31 ATL cases were found...
June 5, 2017: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/28540757/association-of-tuberculosis-status-with-neurologic-disease-and-immune-response-in-htlv-1-infection
#10
Anselmo Souza, Natália Carvalho, Yuri Neves, Silvane Braga Santos, Maria de Lourdes Bastos, Sérgio Arruda, Eduardo Martins Netto, Marshall J Glesby, Edgar Carvalho
The human T cell lymphotropic virus type 1 (HTLV-1) is the etiologic agent of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). HTLV-1 infected individuals have increased susceptibility to Mycobacterium tuberculosis infection but the influence of tuberculosis (TB) on the course of HTLV-1 infection is unknown. The aim of this study was to evaluate the influence of TB on immunological, virologic, and neurologic features of HTLV-1 infection. This is a retrospective analysis of individuals enrolled in a cohort study from an HTLV-1 clinic who were evaluated for past or latent tuberculosis (LTB) and classified clinically as HTLV-1 carriers, probable HAM/TSP and definite HAM/TSP...
June 26, 2017: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/28536850/effectiveness-of-daily-prednisolone-to-slow-progression-of-human-t-lymphotropic-virus-type-1-associated-myelopathy-tropical-spastic-paraparesis-a-multicenter-retrospective-cohort-study
#11
Ariella L G Coler-Reilly, Tomoo Sato, Toshio Matsuzaki, Masanori Nakagawa, Masaaki Niino, Masahiro Nagai, Tatsufumi Nakamura, Norihiro Takenouchi, Natsumi Araya, Naoko Yagishita, Eisuke Inoue, Yoshihisa Yamano
Millions of people are infected with human T-lymphotropic virus type 1 (HTLV-1) worldwide; notable endemic areas include Brazil, the Caribbean islands, Iran, and Japan. A small number of those infected develop the progressive neurodegenerative disease HTLV-1-associated myelopathy (HAM), also known as tropical spastic paraparesis (TSP), which is characterized by chronic spinal cord inflammation and accompanying myelopathic symptoms. The corticosteroid prednisolone (PSL) is a classic treatment for HAM/TSP, yet its effectiveness remains controversial owing to insufficient and conflicting studies...
May 23, 2017: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/28484158/adult-t-cell-leukemia-lymphoma-complicated-by-takotsubo-cardiomyopathy-and-htlv-1-associated-myelopathy-after-treatment-with-the-anti-ccr4-antibody-mogamulizumab
#12
Satoshi Yamanaka, Kazutaka Nakayama, Hayato Tamai, Masanori Sakamaki, Koiti Inokuchi
Adult T-cell leukemia-lymphoma (ATL) caused by human T-lymphotropic virus type 1 (HTLV-1) is generally associated with poor prognosis. The anti-CCR4 antibody mogamulizumab is one of the options for refractory or relapsed ATL. Mogamulizumab is intravenously administered as a single agent at a dose of 1.0 mg/kg once a week for 8 weeks. The overall response rate is reported to be 50%. Reported common adverse events after administration of mogamulizumab are leukocytopenia, infusion reaction, and skin rash. Although rare, mogamulizumab-associated cardiomyopathy has also been reported...
2017: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/28463883/htlv-1-infection-and-disease-in-spain
#13
Carmen de Mendoza, Estrella Caballero, Antonio Aguilera, Silvia Requena, Raúl Ortiz de Lejarazu, María Pirón, Rocío González, Ana Jiménez, Lourdes Roc, Ana Treviño, Rafael Benito, Miriam Fernández-Alonso, Aitziber Aguinaga, Carmen Rodríguez, Juan García-Costa, Lidia Blanco, José M Ramos, Enrique Calderón, José M Eirós, Silvia Sauleda, Pablo Barreiro, Vicente Soriano
: Human T-lymphotropic virus type 1 (HTLV-1) infection is a neglected disease despite roughly 15 million people are chronically infected worldwide. Lifelong less than 10% of carriers develop life-threatening diseases, mostly a subacute myelopathy known as tropical spastic paraparesis (TSP) and a lymphoproliferative disorder named adult T-cell leukemia (ATL). HTLV-1 is efficiently transmitted perinatally (breastfeeding), sexually (more from male to female) and parenterally (transfusions, injection drug use and transplants)...
May 1, 2017: AIDS
https://www.readbyqxmd.com/read/28426803/dendritic-cell-maturation-but-not-type-i-interferon-exposure-restricts-infection-by-htlv-1-and-viral-transmission-to-t-cells
#14
Gergès Rizkallah, Sandrine Alais, Nicolas Futsch, Yuetsu Tanaka, Chloé Journo, Renaud Mahieux, Hélène Dutartre
Human T lymphotropic Virus type 1 (HTLV-1) is the etiological agent of Adult T cell Leukemia/Lymphoma (ATLL) and HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP). Both CD4+ T-cells and dendritic cells (DCs) infected with HTLV-1 are found in peripheral blood from HTLV-1 carriers. We previously demonstrated that monocyte-derived IL-4 DCs are more susceptible to HTLV-1 infection than autologous primary T-cells, suggesting that DC infection precedes T-cell infection. However, during blood transmission, breast-feeding or sexual transmission, HTLV-1 may encounter different DC subsets present in the blood, the intestinal or genital mucosa respectively...
April 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28420387/effects-of-host-restriction-factors-and-the-htlv-1-subtype-on-susceptibility-to-htlv-1-associated-myelopathy-tropical-spastic-paraparesis
#15
Satoshi Nozuma, Eiji Matsuura, Daisuke Kodama, Yuichi Tashiro, Toshio Matsuzaki, Ryuji Kubota, Shuji Izumo, Hiroshi Takashima
BACKGROUND: Although human T-lymphotropic virus type 1 (HTLV-1) infection is a prerequisite for the development of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), specific provirus mutations in HAM/TSP have not yet been reported. In this study, we examined whether HAM/TSP patients had the disease-specific genomic variants of HTLV-1 by analyzing entire sequences of HTLV-1 proviruses in these patients, including familial cases. In addition, we investigated the genetic variants of host restriction factors conferring antiretroviral activity to determine which mutations may be related to resistance or susceptibility to HAM/TSP...
April 19, 2017: Retrovirology
https://www.readbyqxmd.com/read/28410448/il17a-polymorphism-is-not-associated-with-human-t-lymphotropic-virus-1-associated-myelopathy-tropical-spastic-paraparesis
#16
Heytor V P C Neco, Vanessa G S Teixeira, Ana C L Trindade, Paula M R Magalhães, Virgínia M B Lorena, Luydson R Vasconcelos, Patricia M M F Moura, Clarice N L Morais
The human T-lymphotropic virus 1 (HTLV-1) is the causative agent of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). The present study investigated the association between the rs2275913 polymorphism in the IL17A gene and the development of HAM/TSP. Peripheral blood samples were collected from 116 patients (29 symptomatic patients with HAM/TSP and 87 asymptomatic) with a positive diagnosis of HTLV-1. The single nucleotide polymorphism genotyping was carried out by real time quantitative PCR (RT-qPCR) using TaqMan(®) probes...
May 2017: Viral Immunology
https://www.readbyqxmd.com/read/28384290/mait-cells-are-reduced-in-frequency-and-functionally-impaired-in-human-t-lymphotropic-virus-type-1-infection-potential-clinical-implications
#17
Dominic Paquin-Proulx, Benjamin C Greenspun, Emanuela A S Costa, Aluisio C Segurado, Esper G Kallas, Douglas F Nixon, Fabio E Leal
HTLV-1 infection is associated with several inflammatory disorders, including the neurodegenerative condition HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). It is unclear why a minority of infected subjects develop HAM/TSP. The cellular immune response has been implicated in the development of inflammatory alterations in these patients; however the pathogenic mechanisms for disease progression remain unclear. Furthermore, HTLV-1-infected individuals have an increase incidence of Mycobacterium tuberculosis (Mtb) infection, suggesting that immunological defect are associated with HTLV-1 infection...
2017: PloS One
https://www.readbyqxmd.com/read/28384180/silent-dissemination-of-htlv-1-in-an-endemic-area-of-argentina-epidemiological-and-molecular-evidence-of-intrafamilial-transmission
#18
María C Frutos, Rene Gastaldello, Marcos Balangero, Carlos Remondegui, Sebastián Blanco, Koko Otsuki, Ana Carolina Paulo Vicente, David Elías, Arnaldo Mangeaud, Silvia Nates, Sandra Gallego
BACKGROUND: Molecular and epidemiological studies of transmission routes and risk factors for infection by HTLV-1 are extremely important in order to implement control measures, especially because of the high prevalence of HTLV-1 in several regions of the world. San Salvador de Jujuy, Northwest Argentina, is a highly endemic area for HTLV-1 and foci of tropical spastic paraparesis/HTLV-1-associated myelopathy. OBJECTIVE: To gain further insight into the role of intrafamilial transmission of HTLV-1 in a highly endemic region in Argentina...
2017: PloS One
https://www.readbyqxmd.com/read/28380116/clinical-and-laboratory-features-of-htlv-i-asymptomatic-carriers-and-patients-with-htlv-i-associated-myelopathy-tropical-spastic-paraparesis-from-the-brazilian-amazon
#19
Massanobu Takatani, Myuki Esashika Crispim, Nelson Fraiji, Mariane Martins Araujo Stefani, Dagmar Kiesslich
Clinical and laboratory parameters including blood and cerebrospinal fluid (CSF) neopterin were investigated in human-T-lymphotropic-virus-type-I associated-myelopathy/tropical-spastic-paraparesis-HAM/TSP and in HTLV-I carriers. HAM/TSP (n = 11, 2 males/9 females, median age = 48 years), recently diagnosed HTLV-I carriers (n = 21, 15 females/6 males, median age = 44 years), healthy individuals (n = 20, 10 males/10 females, median age = 34.6 years) from the Brazilian Amazon (Manaus, Amazonas State) were investigated...
April 3, 2017: Revista do Instituto de Medicina Tropical de São Paulo
https://www.readbyqxmd.com/read/28378248/role-of-il-21-in-htlv-1-infections-with-emphasis-on-htlv-1-associated-myelopathy-tropical-spastic-paraparesis-ham-tsp
#20
Taraneh Rajaei, Hamid Farajifard, Houshang Rafatpanah, Reza Bustani, Narges Valizadeh, Bahareh Rajaei, Seyed Abdolrahim Rezaee
Interleukin-21 (IL-21) enhances the survival and cytotoxic properties of cytotoxic T cells (CTLs) and exhibits essential roles in controlling chronic viral infections. HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic progressive inflammatory disease of the nervous system. The main determinant of disease progression is efficiency of the CTL response to Human T lymphotropic virus types I (HTLV-1). In this study, the expression of host IL-21 and HTLV-I Tax and proviral load (PVL) was evaluated to understand the role and mechanism of IL-21 in HTLV-1 infections and the subsequent development of HAM/TSP...
April 4, 2017: Medical Microbiology and Immunology
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