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HTLV Myelopathy

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https://www.readbyqxmd.com/read/28101786/evaluation-of-t-regulatory-lymphocytes-transcription-factors-in-htlv-1-associated-myelopathy-tropical-spastic-paraparesis-ham-tsp-patients
#1
Sanaz Ahmadi Ghezeldasht, Hamed Sadeghian, Mahmoud Reza Azarpazhooh, Seyyed Ali Akbar Shamsian, Houshang Rafatpanah, Mahmood Mahmoodi, Seyyed Abdolrahim Rezaee
HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is an aggressive neurological disease. The CD4(+)CD25(+) T cell population plays pivotal roles in the maintenance of immunological tolerance and prevention of such autoimmune diseases. In the current study, proviral load (PVL), factor forkhead box p3 (Foxp3), and glucocorticoid-induced tumor necrosis factor receptor-related protein (GITR) gene expression and regulatory T cells (Tregs) counts of 21 HAM/TSP patients and 16 HTLV-1 healthy carriers (ACs) were measured using real-time PCR, TaqMan method, and flow cytometry...
January 18, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28095504/cytoplasmic-localization-of-htlv-1-hbz-protein-a-biomarker-of-htlv-1-associated-myelopathy-tropical-spastic-paraparesis-ham-tsp
#2
Marco Baratella, Greta Forlani, Goutham U Raval, Alessandra Tedeschi, Olivier Gout, Antoine Gessain, Giovanna Tosi, Roberto S Accolla
HTLV-1 is the causative agent of a severe form of adult T cell leukemia/Lymphoma (ATL), and of a chronic progressive neuromyelopathy designated HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). Two important HTLV-1-encoded proteins, Tax-1 and HBZ, play crucial roles in the generation and maintenance of the oncogenic process. Less information is instead available on the molecular and cellular mechanisms leading to HAM/TSP. More importantly, no single specific biomarker has been described that unambiguously define the status of HAM/TSP...
January 17, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28040482/schistosoma-antigens-downregulate-cxcl9-production-by-pbmc-of-htlv-1-infected-individuals
#3
Luciane Mota Lima, Luciana Santos Cardoso, Silvane Braga Santos, Ricardo Riccio Oliveira, Sérgio Costa Oliveira, Alfredo Miranda Góes, Alex Loukas, Maria Ilma Araujo
: HTLV-1 is the causal agent of Adult T cell Leukemia/lymphoma (ATLL) and HTLV-1-associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP). The immune response to HTLV-1-infection is polarized to the Th1-type, and the presence of CXCL9/CXCL10 chemokines may lead to an increase in the recruitment of pro-inflammatory molecules in spinal cord tissue, contributing to the damage observed in the development of HAM/TSP. It has been observed that in chronic helminth-infections, such as schistosomiasis, there is a deviation toward the Th2/regulatory immune response...
December 28, 2016: Acta Tropica
https://www.readbyqxmd.com/read/28017149/htlv-1-associated-neurological-disorders
#4
Muhammad Yasir Khan, Ishaq Nasib Khan, Muhammad Farman, Saleh Al Karim, Ishtiaq Qadri, Muhammad Amjad Kamal, Khalid Al Ghamdi, Steve Harakeh
Human T-cell lymphotropic virus type 1 (HTLV-1) is a retrovirus which is endemic to certain regions of the world and infects around 10-20 million people. HTLV-1 is the etiologic agent of Adult T cell leukemia/lymphoma and HTLV-1 associated neurological disorders including mainly HTLV-1 associated myelopathy/Tropical spastic paraparesis. The involvement of the central nervous diseases occurs among: HTLV-1 infected patients from endemic areas, HIV positive individuals and drug users. The ability of HTLV-1 to cause associated neuropathies starts with the virus crossing the blood brain barrier (BBB), then entering and infecting the cells of the central nervous system...
December 22, 2016: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/27894665/modulatory-effects-of-curcumin-on-apoptosis-and-cytotoxicity-related-molecules-in-htlv-1-associated-myelopathy-tropical-spastic-paraparesis-ham-tsp-patients
#5
Asadollah Mohammadi, Bahare Fazeli, Marzieh Taheri, Amirhossein Sahebkar, Zohreh Poursina, Vida Vakili, Shadi Zamanian Yazdi, Zahra Keramati, Reza Boostani, Ian Hampson, Houshang Rafatpanah
Apoptosis is a universal cellular defense mechanism against viral infection. Curcumin, an anti-inflammatory phytochemical, induces apoptosis through mitochondrial and receptor-mediated pathways, as well as activation of caspase cascades. Here, we investigated the impact of supplementation with curcumin on the expression of a panel of apoptosis- and cytotoxicity-related genes in patients suffering from HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP), a progressive demyelinating neuroinflammatory disease caused by HTLV-1 infection...
January 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27887847/role-of-the-htlv-1-viral-factors-in-the-induction-of-apoptosis
#6
REVIEW
Mohammad Karimi, Hamed Mohammadi, Maryam Hemmatzadeh, Asadollah Mohammadi, Houshang Rafatpanah, Behzad Baradaran
Adult T-cell leukemia (ATL) and HTLV-1-associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) are the two main diseases that are caused by the HTLV-1 virus. One of the features of HTLV-1 infection is its resistance against programmed cell death, which maintains the survival of cells to oncogenic transformation and underlies the viruses' therapeutic resistance. Two main genes by which the virus develops cancer are Tax and HBZ; playing an essential role in angiogenesis in regulating viral transcription and modulating multiple host factors as well as apoptosis pathways...
January 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27871430/htlv-1-associated-myelopathy-tropical-spastic-paraparesis-ham-tsp-a-comparative-study-to-identify-factors-that-influence-disease-progression
#7
Eiji Matsuura, Satoshi Nozuma, Yuichi Tashiro, Ryuji Kubota, Shuji Izumo, Hiroshi Takashima
OBJECTIVE: HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) can progress slowly or rapidly even though a set of symptoms such as spastic paraparesis with pathological reflexes and sweating loss of the lower extremities are commonly observed in patients. Although most of the patients are thought to be infected to HTLV-1 from their mothers by breast feeding, symptoms of HAM/TSP typically manifest in patients later in life (50-60years old in age) and also with a higher prevalence of women to men at a ratio of approximately 3:1...
December 15, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27845163/the-effect-of-htlv-1-virulence-factors-hbz-tax-proviral-load-hla-class-i-and-plasma-neopterin-on-manifestation-of-htlv-1-associated-myelopathy-tropical-spastic-paraparesis
#8
Hanieh Tarokhian, Mahdi Taghadosi, Hushang Rafatpanah, Taraneh Rajaei, Mahmoud Reza Azarpazhooh, Narges Valizadeh, S A Rahim Rezaee
BACKGROUND: Previous studies have suggested debatable roles of Tax and HBZ gene expression in the pathogenesis of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). In this study, HTLV-1 and host interactions in the manifestation of HAM/TSP were evaluated. METHODS: A cross-sectional study was conducted on 33 HAM/TSP patients and 38 HTLV-1 asymptomatic carriers (ACs). HTLV-1-Tax, HBZ gene expression, and proviral load (PVL) were assessed using the quantitative real-time PCR (TaqMan), host plasma neopterin level, and HLA-I, and the clinical manifestation were evaluated...
January 15, 2017: Virus Research
https://www.readbyqxmd.com/read/27787900/evaluation-of-htlv-1-hbz-and-proviral-load-together-with-host-ifn-%C3%AE-3-in-pathogenesis-of-ham-tsp
#9
Sayed Hamid Reza Mozhgani, Najmeh Jaberi, Seyyed Abdolrahim Rezaee, Reza Bustani, Seyyed Mohammad Jazayeri, Mohammad Mahdi Akbarian, Saeideh Milani, Hanieh Tarokhian, Mehdi Norouzi
Human T-cell lymphotropic virus 1 (HTLV-1) is associated with two progressive diseases: HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and adult T-cell leukemia/lymphoma (ATLL). Although HTLV-1 proviral load (PVL) has been introduced as a risk factor for these diseases' progression, it is not sufficient on its own to yield an accurate estimation of the outcome of the infection. In the present study, PVL and HTLV-1 basic leucine zipper factor (HBZ) expression level as viral factors, and IFN λ3 as a host factor, were evaluated in HAM/TSP patients and HTLV-1 asymptomatic carriers (ACs)...
October 27, 2016: Journal of Medical Virology
https://www.readbyqxmd.com/read/27777805/two-cases-of-human-t-lymphotropic-virus-type-i-associated-myelopathy-tropical-spastic-paraparesis-caused-by-living-donor-renal-transplantation
#10
Yasutaka Tajima, Mariko Matsumura, Hiroaki Yaguchi, Yasunori Mito
In rare instances, recipients of organ transplants from human T-lymphotropic virus type I- (HTLV-I-) positive donors reportedly developed neurologic symptoms due to HTLV-I-associated myelopathy (HAM). We present herein two cases of HAM associated with renal transplantation from HTLV-I seropositive living-donors. The first patient was a 42-year-old woman with chronic renal failure for twelve years and seronegative for HTLV-I. She underwent renal transplantation with her HTLV-I seropositive mother as the donor, and she developed HAM three years after the transplantation...
2016: Case Reports in Neurological Medicine
https://www.readbyqxmd.com/read/27769524/dynamic-acquisition-of-htlv-1-tax-protein-by-mononuclear-phagocytes-role-in-neurologic-disease
#11
Eiji Matsuura, Yoshimi Enose-Akahata, Karen Yao, Unsong Oh, Yuetsu Tanaka, Hiroshi Takashima, Steven Jacobson
Pathology of HTLV-1 associated myelopathy/Tropical spastic paraparesis (HAM/TSP) is believed to be the result of "bystander damage" involving effector CD8 (+) T lymphocytes (CTLs) killing of virus infected cells. But the specific cellular events leading up to tissue injury are still unclear. Here, we developed the Microscopy Imaging of Cytotoxic T lymphocyte assay with Fluorescence emission (MI-CaFé), an optimized visualization analysis to explore the interactions between CTLs and virus infected or viral antigen presenting target cells...
October 3, 2016: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/27678093/long-term-follow-up-of-htlv-1-proviral-load-in-asymptomatic-carriers-and-in-incident-cases-of-ham-tsp-what-is-its-relevance-as-a-prognostic-marker-for-neurologic-disease
#12
Marina Lobato Martins, Jacqueline Cronemberger Guimarães, João Gabriel Ribas, Luiz Cláudio Ferreira Romanelli, Anna Bárbara de Freitas Carneiro-Proietti
HTLV-1 proviral load (pvl) is an important risk marker for HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), but its value as prognostic marker is not well defined. Long-term prospective cohort studies are necessary to clarify this question. Here, we analyzed HTLV-1 pvl in the peripheral blood of 82 asymptomatic carriers (AC; 351 samples), 12 HAM/TSP patients (HAM; 46 samples), and six incident cases of HAM/TSP (iHAM), with serial samples collected before (n = 10) and after (n = 20) the disease onset...
September 27, 2016: Journal of Neurovirology
https://www.readbyqxmd.com/read/27606627/immunological-profile-in-individuals-with-schistosomal-myeloradiculopathy
#13
Ramon de Almeida Kruschewsky, Luciana Santos Cardoso, Jamille Souza Fernandes, Robson da Paixão de Souza, Diego Mota Lopes, Otavio Augusto Moreno de Carvalho, Maria Ilma Araujo
BACKGROUND: Schistosomal myeloradiculopathy (SMR) is the most serious ectopic presentation of Schistosoma mansoni infection. The pathogenesis occurs mainly via the host inflammatory response to the eggs of the parasite that are stuck in the central nervous system, and the diagnosis is generally made by the exclusion of other neurological diseases. OBJECTIVE: We aimed to evaluate the immune status of SMR patients and to identify a marker for SMR diagnosis. METHODS: We enrolled 15 patients with a presumptive diagnosis of SMR, and the control groups included 17 patients with myelopathy associated with human T cell lymphotropic virus type 1 (HTLV-1) and 11 with other neurological disorders...
2016: Neuroimmunomodulation
https://www.readbyqxmd.com/read/27603042/the-fas-670-aa-genotype-is-associated-with-high-proviral-load-in-peruvian-ham-tsp-patients
#14
Jason Rosado, Sandra Morales, Giovanni López, Daniel Clark, Kristien Verdonck, Eduardo Gotuzzo, Guy Van Camp, Michael Talledo
Human T-lymphotropic virus 1 (HTLV-1) is the etiologic agent of the HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Apoptosis is a mechanism of defense elicited by many triggers, including cross-linking of the FAS receptor expressed in viruses-infected cells, and the ligand FASL presented by T-cytotoxic cells. As HAM/TSP has been associated with high levels of proviral load (PVL), we hypothesized that certain genotypes of single-nucleotide polymorphisms (SNPs) associated with a decreased protein expression of FAS and FASL could be risk factors for this disease...
September 7, 2016: Journal of Medical Virology
https://www.readbyqxmd.com/read/27561880/evidence-of-brain-inflammation-in-patients-with-human-t-lymphotropic-virus-type-1-associated-myelopathy-ham-a-pilot-multimodal-imaging-study-using-11c-pbr28-pet-mr-t1-weighted-and-diffusion-weighted-imaging
#15
Rahul Dimber, Qi Guo, Courtney Bishop, Adine Adonis, Aisling Buckley, Agnes Kocsis, David Owen, Nicola Kalk, Rexford Newbould, Roger N Gunn, Eugenii A Rabiner, Graham P Taylor
: HTLV-1-associated myelopathy (HAM; HTLV-1 is human T-lymphotropic virus type 1) is a chronic debilitating neuroinflammatory disease with a predilection for the thoracic cord. Tissue damage is attributed to the cellular immune response to HTLV-1-infected lymphocytes. The brains of HTLV-1-infected patients, with and without HAM but no clinical evidence of brain involvement, were examined using a specific 18-kDa translocator protein ligand, (11)C-PBR28, and T1-weighted and diffusion-weighted MRI...
December 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27553711/analyses-of-htlv-1-sequences-suggest-interaction-between-orf-i-mutations-and-ham-tsp-outcome
#16
Fernanda Khouri Barreto, Ricardo Khouri, Filipe Ferreira de Almeida Rego, Luciane Amorim Santos, Maria Fernanda de Castro-Amarante, Izabela Bialuk, Cynthia A Pise-Masison, Bernardo Galvão-Castro, Antoine Gessain, Steven Jacobson, Genoveffa Franchini, Luiz Carlos Alcantara
The region known as pX in the 3' end of the human T-cell lymphotropic virus type 1 (HTLV-1) genome contains four overlapping open reading frames (ORF) that encode regulatory proteins. HTLV-1 ORF-I produces the protein p12 and its cleavage product p8. The functions of these proteins have been linked to immune evasion and viral infectivity and persistence. It is known that the HTLV-1 infection does not necessarily imply the development of pathological processes and here we evaluated whether natural mutations in HTLV-1 ORF-I can influence the proviral load and clinical manifestation of HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP)...
November 2016: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/27542993/htlv-1-induces-a-th1-like-state-in-cd4-ccr4-t-cells-that-produces-an-inflammatory-positive-feedback-loop-via-astrocytes-in-ham-tsp
#17
Yoshihisa Yamano, Ariella Coler-Reilly
The main feature of Human T-lymphotropic virus type I (HTLV-1) -associated myelopathy/tropical spastic paraparesis (HAM/TSP) pathogenesis is a virus-induced hyperactive immune response that produces chronic inflammation in the central nervous system (CNS), but the mechanism by which HTLV-1 deregulates the immune response is unknown. We recently reported a high frequency of HTLV-1-infected CCR4(+) cells, including regulatory T cells. We showed that HTLV-1 induces a Th1-like state in these CCR4(+) cells via T-bet expression...
August 12, 2016: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/27519553/development-of-neurologic-diseases-in-a-patient-with-primate-t-lymphotropic-virus-type-1-ptlv-1
#18
Yoshimi Enose-Akahata, Breanna Caruso, Benjamin Haner, Emily Charlip, Govind Nair, Raya Massoud, Bridgette J Billioux, Joan Ohayon, William M Switzer, Steven Jacobson
BACKGROUND: Virus transmission from various wild and domestic animals contributes to an increased risk of emerging infectious diseases in human populations. HTLV-1 is a human retrovirus associated with acute T-cell leukemia and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). HTLV-1 originated from ancient zoonotic transmission from nonhuman primates, although cases of zoonotic infections continue to occur. Similar to HTLV-1, the simian counterpart, STLV-1, causes chronic infection and leukemia and lymphoma in naturally infected monkeys, and combined are called primate T-lymphotropic viruses (PTLV-1)...
2016: Retrovirology
https://www.readbyqxmd.com/read/27499015/peridinin-a-carotenoid-inhibits-proliferation-and-survival-of-htlv-1-infected-t-cell-lines
#19
Chie Ishikawa, Takahiro Jomori, Junichi Tanaka, Masachika Senba, Naoki Mori
Human T-cell leukemia virus type 1 (HTLV-1) causes either adult T-cell leukemia (ATL) or chronic inflammatory disorders such as HTLV-1-associated myelopathy/tropical spastic paraparesis. These diseases are not curable as yet; therefore new agents for treatment and prevention are needed. Carotenoids are natural plant compounds with anti-carcinogenic activities. Peridinin is one of the most abundant carotenoids found in nature. Based on a series of past experiments, here we investigated the effects of peridinin extracted from Okinawan coral Isis hippuris on the proliferation and survival of HTLV-1-infected T-cell lines...
October 2016: International Journal of Oncology
https://www.readbyqxmd.com/read/27449854/autoantibodies-to-heterogeneous-nuclear-ribonuclear-protein-a1-hnrnpa1-cause-altered-ribostasis-and-neurodegeneration-the-legacy-of-ham-tsp-as-a-model-of-progressive-multiple-sclerosis
#20
Michael C Levin, Sangmin Lee, Lidia A Gardner, Yoojin Shin, Joshua N Douglas, Hannah Salapa
Several years following its discovery in 1980, infection with human T-lymphotropic virus type 1 (HTLV-1) was shown to cause HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP), a disease biologically similar to progressive forms of multiple sclerosis (MS). In this manuscript, we review some of the clinical, pathological, and immunological similarities between HAM/TSP and MS with an emphasis on how autoantibodies to an RNA binding protein, heterogeneous nuclear ribonuclear protein A1 (hnRNP A1), might contribute to neurodegeneration in immune mediated diseases of the central nervous system...
July 17, 2016: Journal of Neuroimmunology
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