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https://www.readbyqxmd.com/read/29673284/reducing-myeloperoxidase-activity-decreases-inflammation-and-increases-cellular-protection-in-ischemic-stroke
#1
Hyeon J Kim, Ying Wei, Gregory R Wojtkiewicz, Ji Y Lee, Michael A Moskowitz, John W Chen
Myeloperoxidase (MPO) is a pro-inflammatory enzyme abundantly secreted by activated myeloid cells after stroke. We show that when MPO activity is either blocked by the specific inhibitor 4-aminobenzoic acid hydrazide (ABAH) in wildtype (WT) mice or congenitally absent (MPO-/- ), there was decreased cell loss, including degenerating neurons and oligodendrocytes, in the ischemic brains compared to vehicle-treated WT mice after stroke. MPO inhibition also reduced the number of activated myeloid cells after ischemia...
January 1, 2018: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29668388/neuromuscular-changes-of-the-aged-human-hamstrings
#2
Eric A Kirk, Kevin J Gilmore, Charles L Rice
Despite the life-long importance for posture and locomotion, neuromuscular properties of the hamstrings muscle have not been explored with adult ageing. The purpose was to assess and compare age-related effects on contractile function, spinal motor neuron output expressed as motor unit (MU) discharge rates in the hamstrings of 11 young (26 {plus minus} 4 y) and 10 old (80 {plus minus} 5 y) men. Maximal voluntary isometric contractions (MVC), stimulated contractile properties, surface and intramuscular electromyography (EMG) from sub-maximal to MVC were recorded in the biceps femoris (BF) and semimembranosus-semitendinosus (SS) muscles...
April 18, 2018: Journal of Neurophysiology
https://www.readbyqxmd.com/read/29660941/brimapitide-reduced-neuronal-stress-markers-and-cognitive-deficits-in-5xfad-transgenic-mice
#3
Sarah Gourmaud, Priscilla Thomas, Sylvie Thomasseau, Marion Tible, Claire Abadie, Claire Paquet, Jacques Hugon
Alzheimer's disease (AD) is characterized by accumulations of amyloid-β (Aβ42) and hyperphosphorylated tau proteins, associated with neuroinflammation, synaptic loss, and neuronal death. Several studies indicate that c-Jun N-terminal kinase (JNK) is implicated in the pathological features of AD. We have investigated in 5XFAD mice, the therapeutic effects of Brimapitide, a JNK-specific inhibitory peptide previously tested with higher concentrations in another AD model (TgCRND8). Three-month-old 5XFAD and wild-type littermate mice were treated by intravenous injections of low doses (10 mg/kg) of Brimapitide every 3 weeks, for 3 or 6 months (n = 6-9 per group)...
April 11, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29659380/effect-of-pioglitazone-and-simvastatin-in-lipopolysaccharide-induced-amyloidogenesis-and-cognitive-impairment-in-mice-possible-role-of-glutamatergic-pathway-and-oxidative-stress
#4
Sara Thabit, Nesrine S E El Sayed
Neuroinflammation and β-amyloid (Aβ) deposition in the brain are well known characteristics of neurodegeneration. Diabetes and hypercholesterolemia are the main risk factors leading to memory loss and cognitive impairment. Recently, it was found that statins and thiazolidinediones have promising anti-inflammatory and neuroprotective effects that could delay neurodegeneration and neuronal loss in diabetic and hypercholesterolemic patients. The aim of the present study was to investigate the protective effect of simvastatin, pioglitazone, and their combination in lipopolysaccharide (LPS)-induced neuroinflammation and amyloidogenesis...
April 13, 2018: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29649504/tau-pathology-and-neurochemical-changes-associated-with-memory-dysfunction-in-an-optimised-murine-model-of-global-cerebral-ischaemia-a-potential-model-for-vascular-dementia
#5
Sabah Khan, Nadira Y Yuldasheva, Trevor F C Batten, Alasdair R Pickles, Katherine A B Kellett, Sikha Saha
Cerebral ischemia is known to be a major cause of death and the later development of Alzheimer's disease and vascular dementia. However, ischemia induced cellular damage that initiates these diseases remain poorly understood. This is primarily due to lack of clinically relevant models that are highly reproducible. Here, we have optimised a murine model of global cerebral ischaemia with multiple markers to determine brain pathology, neurochemistry and correlated memory deficits in these animals. Cerebral ischaemia in mice was induced by bilateral common carotid artery occlusion...
April 9, 2018: Neurochemistry International
https://www.readbyqxmd.com/read/29643528/-comparison-of-the-properties-of-cd146-positive-and-cd146-negative-subpopulations-of-stem-cells-from-human-exfoliated-deciduous-teeth
#6
X T Wang, N Q Rao, T Jz Fang, Y M Zhao, L H Ge
OBJECTIVE: Stem cells from human exfoliated teeth (SHED) were sorted by magnetically activated cell sorting (MACS) technique to obtain the CD146 positive and negative cell subpopulation. Then the biological characteristics of these subpopulations were compared to explore their specific application potential in tissue engineering. METHODS: In this study, freshly extracted deciduous teeth without any caries or dental pulp disease were obtained. SHED was isolated using enzyme digestion method and then sorted by MACS, CD146 positive cells and CD146 negative cells were obtained after cell sorting...
April 18, 2018: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29630128/therapeutic-dosage-of-ozone-inhibits-autophagy-and-apoptosis-of-nerve-roots-in-a-chemically-induced-radiculoneuritis-rat-model
#7
M-Y Wu, C-Y Xing, J-N Wang, Y Li, X-W Lin, Z-J Fu
OBJECTIVE: Radiculoneuritis characterizes by the neurogenic pain along the back of patients. This study aims to investigate the therapeutic effects of ozone on radiculoneuritis and the associated mechanisms in rat models. MATERIALS AND METHODS: A chemical radiculoneuritis rat model was successfully established. The rats were divided into 3 groups, including radiculoneuritis Model rats group (Model group, n=18), Ozone therapy group (n=18), and Normal control group (n=18)...
March 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29630101/efficacy-of-computed-tomography-guided-implantation-of-125i-seeds-in-the-treatment-of-refractory-malignant-tumors-accompanied-with-cancer-pain-and-its-influence-on-tumor-markers-in-the-serum
#8
F Duan, X-L Su, Z-X Wei, D-W Kong, T-Y Huang, S Wang
OBJECTIVE: This study intended to explore the efficacy of computed tomography (CT)-guided implantation of iodine-125 (125I) seeds in the treatment of refractory malignant tumors with cancer pain and its influence on tumor markers in the serum. PATIENTS AND METHODS: 76 patients with refractory malignant tumors accompanied by cancer pain that received treatments in LongHua Hospital Shanghai University of Traditional Chinese Medicine from September 2013 to August 2014 were selected...
March 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29615686/lentiviral-vector-delivery-of-short-hairpin-rna-to-ngr1-promotes-nerve-regeneration-and-locomotor-recovery-in-injured-rat-spinal-cord
#9
Xiaoyang Zhao, Zhiming Peng, Lingli Long, Ningning Chen, Haichong Zheng, David Y B Deng, Yong Wan
Nogo receptor 1 (NgR1) is a high-affinity receptor of myelin-associated inhibitors (MAIs), and suppresses neurogenesis. Lentiviral vector are commonly used to alter the expression of targeted genes. However, little is known about the potential function of lentiviral vector harboring NgR1 shRNA (LV-NgR1 shRNA) on neurogenesis in spinal cord injury (SCI). In this study, the rats were randomly divided into three groups: including the LN (LV-NgR1 shRNA injection), LC (LV-control shRNA injection) and Sham (laminectomy only)...
April 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29579552/proliferative-hippocampal-activity-in-a-group-of-patients-with-rasmussen-s-encephalitis-neuronal-glial-and-bdnf-tissue-expression-correlations
#10
Elane N Magno
Rasmussen's encephalitis (RE) is a rare and devastating unilateral inflammatory brain disease that causes severe and intractable partial epilepsy. It has been shown that epilepsy and subsequent inflammation have deleterious influence on hippocampal cell survival and neurogenesis, but this still has not been systematically explored in human tissue. In this study, we investigated the correlation between inflammation and epilepsy as well as the rates of hippocampal gliogenesis and neurogenesis in a pediatric group of six patients with RE and six control cases...
March 23, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29576121/anti-nociceptive-effects-of-caloric-restriction-on-neuropathic-pain-in-rats-involves-silent-information-regulator-1
#11
Y Liu, Y Ni, W Zhang, Y E Sun, M Jiang, W J Gu, Z L Ma, X P Gu
BACKGROUND: Caloric restriction (CR) increases both average and maximum lifespan, retards physiological signs of ageing, and delays the onset of several diseases and may mediate neuropathic pain. Neuropathic pain seriously affects the quality of life of patients. In this study, we investigated whether CR exerts anti-nociceptive effects on neuropathic pain, and probed its potential mechanisms. METHODS: Adult rats were divided into two dietary groups: an ad libitum (AL)-fed group and a CR group, which was provided with 60% of the food intake of AL rats for 6 weeks...
April 2018: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29562823/nano-pulsed-laser-therapy-is-neuroprotective-in-a-rat-model-of-blast-induced-neurotrauma
#12
Rinat O Esenaliev, Irene Y Petrov, Yuriy Petrov, Jutatip Guptarak, Deborah R Boone, Emanuele Mocciaro, Harris Weisz, Margaret O Parsley, Stacy L Sell, Helen L Hellmich, Jonathan M Ford, Connor Pogue, Douglas DeWitt, Donald S Prough, Maria Adelaide Micci
We have developed a novel, non-invasive Nano-Pulsed Laser Therapy (NPLT) system that combines the benefits of near-infrared laser light (808 nm) and ultrasound (optoacoustic) waves, which are generated with each short laser pulse within the tissue. We tested NPLT in a rat model of blast-induced neurotrauma to determine whether transcranial application of NPLT provides neuroprotective effects. The laser pulses were applied on the intact rat head one hour after injury using a specially developed fiber-optic system...
March 21, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29555581/polycomb-trithorax-group-dependent-regulation-of-the-neuronal-gene-lim3-involved-in-drosophila-lifespan-control
#13
Olga Y Rybina, Yakov M Rozovsky, Ekaterina R Veselkina, Elena G Pasyukova
Molecular mechanisms governing gene expression and defining complex phenotypes are central to understanding the basics of development and aging. Here, we demonstrate that naturally occurring polymorphisms of the Lim3 regulatory region that are associated with variation in gene expression and Drosophila lifespan control are located exclusively in the Polycomb response element (PRE). We find that the Polycomb group (PcG) protein Polycomb (PC) is bound to the PRE only in embryos where Lim3 is present in both repressed and active states...
March 16, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29546864/preliminary-data-on-some-behavioral-changes-induced-by-short-term-intraperitoneal-oxytocin-administration-in-aged-rats
#14
Ioana Miruna Balmus, Radu Lefter, Alin Ciobica, Iulia Antioch, Daniela Ababei, Romeo Dobrin
INTRODUCTION: Oxytocin (OT) is a well-known neuropeptides which together with vasopressin, melatonin, insulin and other hormones can alter both behavior and physiological or neuronal functions. This growing interest on OT roles is also based on the demonstrated beneficial effects as a stress reliever and a social bonding agent. The association between old age and OT was only vaguely studied. Little or few is known on the effect of the OT hormone on the old body. Hereby, we present our preliminary results in the research on behavioral changes regarding the intraperitoneal administration of OT in aged rats...
March 2018: Psychiatria Danubina
https://www.readbyqxmd.com/read/29541577/-18-f-fallypride-characterization-of-striatal-and-extrastriatal-d-2-3-receptors-in-parkinson-s-disease
#15
Adam J Stark, Christopher T Smith, Kalen J Petersen, Paula Trujillo, Nelleke C van Wouwe, Manus J Donahue, Robert M Kessler, Ariel Y Deutch, David H Zald, Daniel O Claassen
Parkinson's disease (PD) is characterized by widespread degeneration of monoaminergic (especially dopaminergic) networks, manifesting with a number of both motor and non-motor symptoms. Regional alterations to dopamine D2/3 receptors in PD patients are documented in striatal and some extrastriatal areas, and medications that target D2/3 receptors can improve motor and non-motor symptoms. However, data regarding the combined pattern of D2/3 receptor binding in both striatal and extrastriatal regions in PD are limited...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29536742/neuronal-regeneration-in-injured-rat-spinal-cord-after-human-dental-pulp-derived-neural-crest-stem-cell-transplantation
#16
S Kabatas, C S Demir, E Civelek, I Yilmaz, A Kircelli, C Yilmaz, Y Akyuva, E Karaoz
OBJECTIVE: This study aimed to analyze the effect of human Dental Pulp-Neural Crest Stem Cells (hDP-NCSCs) delivery on lesion site after spinal cord injury (SCI), and to observe the functional recovery after transplantation. METHODS: Neural Crest Stem Cells (NCSCs) were isolated from human Dental Pulp (hDP). The experimental rat population was divided into four groups (n = 6/24). Their behavioral motility was scored regularly. After 4-weeks, rats were sacrificed, and their spinal cords were examined for Green Fluorescent Protein (GFP) labeled hDP-NCSCs by immunofluorescence (IF) staining...
2018: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/29524783/resveratrol-promotes-the-arcuate-nucleus-architecture-remodeling-to-produce-more-anorexigenic-neurons-in-high-fat-diet-fed-mice
#17
Maryam Safahani, Hadi Aligholi, Farshid Noorbakhsh, Mahmoud Djalali, Hamideh Pishva, Sayed Mostafa Modarres Mousavi, Fatemeh Alipour, Ali Gorji, Fariba Koohdani
OBJECTIVE: Adult hypothalamic neurogenesis has been considered a central regulator of energy balance. Resveratrol (RSV), a natural polyphenol, influences the body fat mass and reduces the amount of adipose tissue. The present study was designed to evaluate the effect of RSV on dynamic of hypothalamic neurons in a diet-induced obesity model of mice. METHODS: Apoptosis, neurogenesis, the expression of the main trophic factors, and the fate of newborn cells were evaluated in the hypothalamus of adult male C57 BL/6 J mice fed a normal diet, a high-fat (HF) diet, or an HF diet supplemented with 400 mg/kg RSV (HF + RSV) for 6 wk...
December 2, 2017: Nutrition
https://www.readbyqxmd.com/read/29518615/plasmid-based-gene-therapy-with-hepatocyte-growth-factor-stimulates-peripheral-nerve-regeneration-after-traumatic-injury
#18
M А Boldyreva, I V Bondar, I S Stafeev, P I Makarevich, I B Beloglazova, E S Zubkova, E K Shevchenko, Y D Molokotina, M N Karagyaur, Е I Rаtner, Ye V Parfyonova
Peripheral nerve injury remains a common clinical problem with no satisfactory treatment options. Numerous studies have shown that hepatocyte growth factor (HGF) exerts neurotrophic effect in motor, sensory, and parasympathetic neurons in addition to mitogenic, morphogenic, angiogenic, antiapoptotic, antifibrotic, and anti-inflammatory effect on various tissues and cells. In our study we examined efficacy of gene therapy with HGF-bearing plasmid (pC4W-hHGF) to improve consequences of traumatic nerve injury in mice...
March 5, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29513607/role-of-the-inferior-alveolar-nerve-in-rodent-lower-incisor-stem-cells
#19
S Hayano, Y Fukui, N Kawanabe, K Kono, M Nakamura, Y Ishihara, H Kamioka
In developing teeth, the sequential and reciprocal interactions between epithelial and mesenchymal tissues promote stem/progenitor cell differentiation. However, the origin of the stem/progenitor cells has been the subject of considerable debate. According to recent studies, mesenchymal stem cells originate from periarterial cells and are regulated by neurons in various organs. The present study examined the role of innervation in tooth development and rodent incisor stem/progenitor cell homeostasis. Rodent incisors continuously grow throughout their lives, and the lower incisors are innervated by the inferior alveolar nerve (IAN)...
March 1, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/29509267/protective-effect-of-tauroursodeoxycholic-acid-on-the-autophagy-of-nerve-cells-in-rats-with-acute-spinal-cord-injury
#20
L Miao, Y Dong, F-B Zhou, Y-L Chang, Z-G Suo, H-Q Ding
OBJECTIVE: To investigate the impact and protective effect of tauroursodeoxycholic acid (TUDCA) on the autophagy of nerve cells in rats with acute spinal cord injury. MATERIALS AND METHODS: Seventy-two 6-8-week-old male Sprague-Dawley (SD) rats were selected and were randomly divided into a sham operation group, a saline control group and a TUDCA treatment group (high and low dose groups). The experimental animals were sacrificed at 24 hours, 5 days and 10 days after spinal cord injury...
February 2018: European Review for Medical and Pharmacological Sciences
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