keyword
https://read.qxmd.com/read/37966374/chronic-alcohol-and-nicotine-consumption-as-catalyst-for-systemic-inflammatory-storm-and-bone-destruction-in-apical-periodontitis
#1
JOURNAL ARTICLE
Karem Paula Pinto, Tatiana Kelly da Silva Fidalgo, Carolina Oliveira de Lima, Ricardo Tadeu Lopes, Liana Bastos Freitas-Fernandes, Ana Paula Valente, Luciana Moura Sassone, Emmanuel João Nogueira Leal Silva
AIM: To assess the periapical alveolar bone pattern and the serum levels of proinflammatory cytokines, biochemical markers and metabolites in rats subjected to chronic alcohol and nicotine consumption and induced apical periodontitis. METHODOLOGY: Twenty-eight male Wistar rats were divided into four groups: Control, Alcohol, Nicotine and Alcohol+Nicotine. The alcohol groups were exposed to self-administration of a 25% alcohol solution, while the other groups were given only filtered water...
November 15, 2023: International Endodontic Journal
https://read.qxmd.com/read/37754339/a-new-way-to-model-periodontitis-in-laboratory-animals
#2
JOURNAL ARTICLE
Denis Moiseev, Sergey Donskov, Ivan Dubrovin, Mariya Kulyukina, Yuriy Vasil'ev, Beatrice Volel, Shodiya Shadieva, Aleksey Babaev, Juliya Shevelyuk, Anatolij Utyuzh, Ellina Velichko, Sergey Dydykin, Irina Dydykina, Yuri Paramonov, Ekaterina Faustova
UNLABELLED: The prevalence of periodontal diseases is increasing, tends to increase with age and is considered as one of the main causes of tooth loss. To assess the effectiveness of new methods of treatment of periodontal diseases, studies on laboratory animals can be promising. THE AIM OF THE STUDY: to develop a new method of accelerated modeling of experimental periodontitis on laboratory animals. MATERIAL AND METHODS: The study was carried out on 22 female rats...
September 18, 2023: Dentistry Journal
https://read.qxmd.com/read/36642451/-effects-of-prenatal-nicotine-exposure-on-enamel-formation-of-offspring-mice
#3
JOURNAL ARTICLE
Q L Tian, D F Zhao, S Y Guan, Y Zhou, X Zhou, L W Zheng
Objective: To investigate the effects of nicotine on the morphology, structure of offspring's dental germ, enamel organ and other dental tissues and the further potential epigenetic mechanisms by establishing prenatal nicotine exposure mouse model. Methods: Ten C57BL/6 pregnant mice were randomly divided into control group (physiological saline subcutaneous injection) and prenatal nicotine exposure (PNE) group (nicotine subcutaneous injection) by using a random number table. Postnatal day 0 (P0), postnatal day 14 (P14) and postnatal day 25 (P25) offspring mice were collected for subsequent experiments...
January 9, 2023: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
https://read.qxmd.com/read/36585711/comparison-of-periodontal-status-and-salivary-il-15-and-18-levels-in-cigarette-smokers-and-individuals-using-electronic-nicotine-delivery-systems
#4
JOURNAL ARTICLE
Dena Ali, Isaac Kuyunov, Jagan Kumar Baskaradoss, Toshinari Mikami
BACKGROUND: It is hypothesized that periodontal status is compromised and whole salivary (WS) interleukin (IL)-15 and IL-18 levels are higher among cigarette-smokers and electronic-nicotine-delivery-systems (ENDS)-users than never-smokers. The aim of the present case-control study was to compare the periodontal status and WS IL-15 and -18 levels among cigarette-smokers, ENDS-users and controls (never-smokers). METHODS: Participants were divided into 4 groups as follows: Group-1:Current cigarette-smokers; Group-2:ENDS-users; Group-3:Never-smokers with periodontitis; and Group-4: Never-smokers without periodontitis...
December 30, 2022: BMC Oral Health
https://read.qxmd.com/read/34993689/effects-of-smoking-on-the-bone-alkaline-phosphatase-in-peri-implant-crevicular-fluid-and-implant-stability-quotient-around-implants-before-loading
#5
JOURNAL ARTICLE
Gulay Tuter, Arzu Zeynep Yildirim, Ayse Nurcan Duman, Behruz Aliyev, Aysegul Atak-Yucel, Nihan Oruklu, Elifcan Kivrak
We aimed to examine the implant stability quotient (ISQ), alveolar bone level measurements (ABL), and bone alkaline phosphatase (BALP) in peri-implant crevicular fluid (PICF) around implants in smokers and non-smokers before loading in 3 months. 44 dental implants were placed into smoker and non-smoker patients equally. ISQ was measured at baseline and 3 months after surgery. The levels of PICF BALP and alveolar bone were measured. ISQ values significantly increased in smokers and non-smokers in the 3rd month (p < 0...
July 2022: Odontology
https://read.qxmd.com/read/34275884/effect-of-nicotine-on-orthodontic-tooth-movement-and-bone-remodeling-in-rats
#6
JOURNAL ARTICLE
Sung-Hee Lee, Jung-Yul Cha, Sung-Hwan Choi, Baek-Il Kim, Jae-Kook Cha, Chung-Ju Hwang
Objective: To quantitatively analyze the effect of nicotine on orthodontic tooth movement (OTM) and bone remodeling in rats using micro-computed tomography and tartrate-resistant acid phosphatase immunostaining. Methods: Thirty-nine adult male Sprague-Dawley rats were randomized into three groups: group A, 0.5 mL normal saline (n = 9, 3 per 3, 7, and 14 days); group B, 0.83 mg/kg nicotine (n = 15, 5 per 3, 7, and 14 days); and group C, 1.67 mg/kg nicotine (n = 15, 5 per 3, 7, and 14 days)...
July 25, 2021: Korean Journal of Orthodontics
https://read.qxmd.com/read/31516483/effect-of-tobacco-on-periodontal-disease-and-oral-cancer
#7
REVIEW
Yixin Zhang, Jinxiu He, Bing He, Ruijie Huang, Mingyun Li
INTRODUCTION: Periodontal disease and oral cancer are common health hazards. Epidemiological investigations show that smoking, periodontal disease and oral cancer are closely related. Tobacco is one of the major risk factors for periodontitis and oral cancer. METHODS: A systematic literature review was performed. To identify relevant studies, the following online databases were searched using specific keywords: PubMed, Web of Science and CNKI. RESULTS: Tobacco not only possesses an addictive effect, but it aggravates periodontal disease by promoting the invasion of pathogenic bacteria, inhibiting autoimmune defense, aggravating the inflammatory reaction, and aggravating the loss of alveolar bone...
2019: Tobacco Induced Diseases
https://read.qxmd.com/read/31407428/tobacco-product-usage-as-a-risk-factor-for-dental-implants
#8
REVIEW
Fawad Javed, Irfan Rahman, Georgios E Romanos
The oral cavities of tobacco smokers and users of smokeless tobacco products are exposed to high concentrations of nicotine. A limited number of animal studies have assessed the effect of nicotine on osseointegration. Results from experimental studies have reported a statistically significant decrease, at 4 weeks of follow-up, in bone-to-implant contact among rats exposed to nicotine compared with unexposed rats. Nicotine increases the production of inflammatory cytokines (such as interleukin-6 and tumor necrosis factor-alpha) by osteoblasts...
October 2019: Periodontology 2000
https://read.qxmd.com/read/30584539/the-effect-of-smoking-behavior-on-alveolar-bone-marrow-mesenchymal-stem-cells-of-clinical-implant-patient
#9
JOURNAL ARTICLE
Xicong Zhao, Bin Zhu, Yan Duan, Xin Wang, Dehua Li
Objective: The hazardous effects of smoking on the alveolar bone healing after implant surgery and nicotine on the biofunction of human alveolar bone marrow mesenchymal stem cells (hABMMSCs) were reported. There was little direct evidence regarding the specific detrimental effects of the smoking on hABMMSCs. The aim of this study was to test the influence of smoking behavior on hABMMSCs and the osseointegration situation after implant surgery. Methods: hABMMSCs from 6 dental implant patients randomly (3 smokers and 3 nonsmokers) were compared...
2018: BioMed Research International
https://read.qxmd.com/read/30309879/prevention-of-perinatal-nicotine-induced-bone-marrow-mesenchymal-stem-cell-myofibroblast-differentiation-by-augmenting-the-lipofibroblast-phenotype
#10
JOURNAL ARTICLE
Reiko Sakurai, Jie Liu, Ying Wang, John S Torday, Virender K Rehan
Perinatal nicotine exposure drives the differentiation of alveolar lipofibroblasts (LIFs), which are critical for lung injury repair, to myofibroblasts (MYFs), which are the hallmark of chronic lung disease. Bone marrow-derived mesenchymal stem cells (BMSCs) are important players in lung injury repair; however, how these cells are affected with perinatal nicotine exposure and whether these can be preferentially driven to a lipofibroblastic phenotype are not known. We hypothesized that perinatal nicotine exposure would block offspring BMSCs lipogenic differentiation, driving these cells towards a MYF phenotype...
October 11, 2018: Clinical Science (1979-)
https://read.qxmd.com/read/29940630/morpho-histological-assessment-of-the-periodontal-support-structures-under-the-action-of-excessive-occlusal-forces-and-under-the-influence-of-nicotine
#11
RANDOMIZED CONTROLLED TRIAL
Ana Ispas, Carmen Mihaela Mihu, Antarinia Maria Crăciun, Mariana Constantiniuc
Smoking and occlusal trauma are two factors that can interfere with bone homeostasis. The aim of this study was to evaluate the histocellular changes occurring in the periodontal ligament and alveolar bone during the action of excessive occlusal forces, and to assess the influence of nicotine on the alveolar bone loss in teeth subjected to occlusal trauma. MATERIALS AND METHODS: Fifty-six Wistar rats were randomized into seven groups (n=8). Animals were exposed to nicotine and occlusal trauma for 7, 14 and 30 days...
2018: Romanian Journal of Morphology and Embryology
https://read.qxmd.com/read/29843070/influence-of-nicotine-on-orthodontic-tooth-movement-a-systematic-review-of-experimental-studies-in-rats
#12
REVIEW
Dimitrios Michelogiannakis, P Emile Rossouw, Deema Al-Shammery, Zohaib Akram, Junad Khan, Georgios E Romanos, Fawad Javed
OBJECTIVE: The objective of this systematic review was to assess the impact of nicotine administration on orthodontic tooth movement (OTM). METHODS: A systematic search was conducted in PubMed, Scopus, EMBASE, MEDLINE (OVID) and Web of Knowledge databases and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed. Studies evaluating the influence of nicotine on OTM, and with the presence of a control group (OTM without nicotine administration), were included...
May 23, 2018: Archives of Oral Biology
https://read.qxmd.com/read/28944930/protective-effect-of-catalpol-on-nicotine%C3%A2-induced-injury-of-alveolar-bone-and-associated-underlying-mechanisms
#13
JOURNAL ARTICLE
Yanwu Li, Xingai Jin, Limin Mao
Smoking is an important factor that causes periodontitis, which manifests as alveolar bone injury and absorption, and has a high incidence and unfavorable treatment efficacy. Nicotine causes ischemia and inflammation of the periodontium and inhibits the mineralization of alveolar bones. Previous studies have revealed the anti‑tumor biological activities of catalpol, in addition to neuroprotection and anti‑inflammation. The present study therefore investigated the underlying protective mechanism of catalpol in alveolar bone injury...
December 2017: Molecular Medicine Reports
https://read.qxmd.com/read/27203240/the-effects-of-cigarette-smoke-condensate-and-nicotine-on-periodontal-tissue-in-a-periodontitis-model-mouse
#14
JOURNAL ARTICLE
Mikiko Kubota, Manabu Yanagita, Kenta Mori, Shiori Hasegawa, Motozo Yamashita, Satoru Yamada, Masahiro Kitamura, Shinya Murakami
Cigarette smoking is a major lifestyle-related risk factor for periodontal diseases. However, the pathophysiological role of cigarette smoking in periodontal disease has yet to be fully elucidated. Here we report that the systemic administration of cigarette smoke condensate or nicotine, which is the major ingredient of cigarette smoke, augmented alveolar bone loss. Concomitantly, the number of osteoclasts in periodontal tissues increased and the expression of receptor activator of nuclear factor κB ligand was upregulated at the ligated side in mice with periodontitis...
2016: PloS One
https://read.qxmd.com/read/26553320/impact-of-nicotine-on-the-interplay-between-human-periodontal-ligament-cells-and-cd4-t-cells
#15
JOURNAL ARTICLE
Xin Ge, Ying-Feng Liu, Yong Wong, Li-Zheng Wu, Ling Tan, Fen Liu, Xiao-Jing Wang
Periodontitis is a common infectious disease associated with destruction of periodontal ligaments and alveolar bones. CD4(+) T cell-mediated immune response is involved in the progression of periodontitis. Tobacco consumption increases the risk of periodontal disease. However, the impact of nicotine on the interaction between human periodontal ligament (PDL) cells and CD4(+) T cells remains unrevealed. Our study aims to investigate the effect of nicotine on PDL cells and the cocultured CD4(+) T cells. The PDL cell cultures were established by explants from healthy individuals, exposed to nicotine or α-bungarotoxin (α-BTX), and incubated solely or in combination with CD4(+) T cells...
September 2016: Human & Experimental Toxicology
https://read.qxmd.com/read/26545755/antimicrobial-photodynamic-therapy-minimizes-the-deleterious-effect-of-nicotine-in-female-rats-with-induced-periodontitis
#16
JOURNAL ARTICLE
Erivan Clementino Gualberto, Letícia Helena Theodoro, Mariellén Longo, Vivian Cristina Noronha Novaes, Maria José Hitomi Nagata, Edilson Ervolino, Valdir Gouveia Garcia
The aim of this study was to compare the use of antimicrobial photodynamic therapy (aPDT) as an adjunct to scaling and root planing (SRP) in the treatment of experimentally induced periodontitis in female rats that were systemically treated with or without nicotine. Female rats (n = 180) were divided into two groups: vehicle administration (Veh) and nicotine administration (Nic). Mini-pumps containing either vehicle or nicotine were implanted in the rats 30 days before the induction of experimental periodontitis (EP)...
January 2016: Lasers in Medical Science
https://read.qxmd.com/read/26451017/cholinergic-pathway-suppresses-pulmonary-innate-immunity-facilitating-pneumonia-after-stroke
#17
JOURNAL ARTICLE
Odilo Engel, Levent Akyüz, Andrey C da Costa Goncalves, Katarzyna Winek, Claudia Dames, Mareike Thielke, Susanne Herold, Chotima Böttcher, Josef Priller, Hans Dieter Volk, Ulrich Dirnagl, Christian Meisel, Andreas Meisel
BACKGROUND AND PURPOSE: Temporary immunosuppression has been identified as a major risk factor for the development of pneumonia after acute central nervous system injury. Although overactivation of the sympathetic nervous system was previously shown to mediate suppression of systemic cellular immune responses after stroke, the role of the parasympathetic cholinergic anti-inflammatory pathway in the antibacterial defense in lung remains largely elusive. METHODS: The middle cerebral artery occlusion model in mice was used to examine the influence of the parasympathetic nervous system on poststroke immunosuppression...
November 2015: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/26048072/nicotine-stimulation-increases-proliferation-and-matrix-metalloproteinases-2-and-28-expression-in-human-dental-pulp-cells
#18
JOURNAL ARTICLE
Rizzi Manuela, Migliario Mario, Rocchetti Vincenzo, Renò Filippo
AIMS: Dental pulp is the specialized tissue responsible for maintaining tooth viability. When tooth mineralized matrix is damaged, pulp is exposed to a plethora of environmental stimuli. In particular, in smokers, pulp become exposed to very high concentrations of nicotine. The aim of this study was to investigate the effect of direct nicotine stimulation on human dental pulp cell proliferation. Moreover, as it is known that nicotine could upregulate the expression of matrix metalloproteinases (MMPs), enzymes involved in pulpal inflammation, the effects of nicotine stimulation on MMP-2 and MMP-28 gene expression have also been investigated...
August 15, 2015: Life Sciences
https://read.qxmd.com/read/25803612/the-nicotinic-receptor-alpha7-impacts-the-mouse-lung-response-to-lps-through-multiple-mechanisms
#19
JOURNAL ARTICLE
Elena Y Enioutina, Elizabeth J Myers, Petr Tvrdik, John R Hoidal, Scott W Rogers, Lorise C Gahring
The nicotinic acetylcholine receptor alpha7 (α7) is expressed by neuronal and non-neuronal cells throughout the body. We examined the mechanisms of the lung inflammatory response to intranasal (i.n.) lipopolysaccharide (LPS) regulated by α7. This was done in mice using homologous recombination to introduce a point mutation in the α7 receptor that replaces the glutamate residue 260 that lines the pore with alanine (α7E260A), which has been implicated in controlling the exceptional calcium ion conductance of this receptor...
2015: PloS One
https://read.qxmd.com/read/24945520/nicotine-effect-on-bone-remodeling-during-orthodontic-tooth-movement-histological-study-in-rats
#20
COMPARATIVE STUDY
Ricardo Lima Shintcovsk, Luégya Knop, Orlando Motohiro Tanaka, Hiroshi Maruo
INTRODUCTION: Nicotine is harmful to angiogenesis, osteogenesis and synthesis of collagen. OBJECTIVE: The aim of this study was to investigate the effect of nicotine on bone remodeling during orthodontic movement in rats. METHODS: Eighty male Wistar rats were randomly divided into three groups: Group C (control), group CM (with orthodontic movement) and group NM (nicotine with orthodontic movement) groups. The animals comprising groups C and CM received 0...
March 2014: Dental Press Journal of Orthodontics
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