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https://www.readbyqxmd.com/read/27203240/the-effects-of-cigarette-smoke-condensate-and-nicotine-on-periodontal-tissue-in-a-periodontitis-model-mouse
#1
Mikiko Kubota, Manabu Yanagita, Kenta Mori, Shiori Hasegawa, Motozo Yamashita, Satoru Yamada, Masahiro Kitamura, Shinya Murakami
Cigarette smoking is a major lifestyle-related risk factor for periodontal diseases. However, the pathophysiological role of cigarette smoking in periodontal disease has yet to be fully elucidated. Here we report that the systemic administration of cigarette smoke condensate or nicotine, which is the major ingredient of cigarette smoke, augmented alveolar bone loss. Concomitantly, the number of osteoclasts in periodontal tissues increased and the expression of receptor activator of nuclear factor κB ligand was upregulated at the ligated side in mice with periodontitis...
2016: PloS One
https://www.readbyqxmd.com/read/26553320/impact-of-nicotine-on-the-interplay-between-human-periodontal-ligament-cells-and-cd4-t-cells
#2
Xin Ge, Ying-Feng Liu, Yong Wong, Li-Zheng Wu, Ling Tan, Fen Liu, Xiao-Jing Wang
Periodontitis is a common infectious disease associated with destruction of periodontal ligaments and alveolar bones. CD4(+) T cell-mediated immune response is involved in the progression of periodontitis. Tobacco consumption increases the risk of periodontal disease. However, the impact of nicotine on the interaction between human periodontal ligament (PDL) cells and CD4(+) T cells remains unrevealed. Our study aims to investigate the effect of nicotine on PDL cells and the cocultured CD4(+) T cells. The PDL cell cultures were established by explants from healthy individuals, exposed to nicotine or α-bungarotoxin (α-BTX), and incubated solely or in combination with CD4(+) T cells...
September 2016: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/26545755/antimicrobial-photodynamic-therapy-minimizes-the-deleterious-effect-of-nicotine-in-female-rats-with-induced-periodontitis
#3
Erivan Clementino Gualberto, Letícia Helena Theodoro, Mariellén Longo, Vivian Cristina Noronha Novaes, Maria José Hitomi Nagata, Edilson Ervolino, Valdir Gouveia Garcia
The aim of this study was to compare the use of antimicrobial photodynamic therapy (aPDT) as an adjunct to scaling and root planing (SRP) in the treatment of experimentally induced periodontitis in female rats that were systemically treated with or without nicotine. Female rats (n = 180) were divided into two groups: vehicle administration (Veh) and nicotine administration (Nic). Mini-pumps containing either vehicle or nicotine were implanted in the rats 30 days before the induction of experimental periodontitis (EP)...
January 2016: Lasers in Medical Science
https://www.readbyqxmd.com/read/26451017/cholinergic-pathway-suppresses-pulmonary-innate-immunity-facilitating-pneumonia-after-stroke
#4
Odilo Engel, Levent Akyüz, Andrey C da Costa Goncalves, Katarzyna Winek, Claudia Dames, Mareike Thielke, Susanne Herold, Chotima Böttcher, Josef Priller, Hans Dieter Volk, Ulrich Dirnagl, Christian Meisel, Andreas Meisel
BACKGROUND AND PURPOSE: Temporary immunosuppression has been identified as a major risk factor for the development of pneumonia after acute central nervous system injury. Although overactivation of the sympathetic nervous system was previously shown to mediate suppression of systemic cellular immune responses after stroke, the role of the parasympathetic cholinergic anti-inflammatory pathway in the antibacterial defense in lung remains largely elusive. METHODS: The middle cerebral artery occlusion model in mice was used to examine the influence of the parasympathetic nervous system on poststroke immunosuppression...
November 2015: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/26048072/nicotine-stimulation-increases-proliferation-and-matrix-metalloproteinases-2-and-28-expression-in-human-dental-pulp-cells
#5
Rizzi Manuela, Migliario Mario, Rocchetti Vincenzo, Renò Filippo
AIMS: Dental pulp is the specialized tissue responsible for maintaining tooth viability. When tooth mineralized matrix is damaged, pulp is exposed to a plethora of environmental stimuli. In particular, in smokers, pulp become exposed to very high concentrations of nicotine. The aim of this study was to investigate the effect of direct nicotine stimulation on human dental pulp cell proliferation. Moreover, as it is known that nicotine could upregulate the expression of matrix metalloproteinases (MMPs), enzymes involved in pulpal inflammation, the effects of nicotine stimulation on MMP-2 and MMP-28 gene expression have also been investigated...
August 15, 2015: Life Sciences
https://www.readbyqxmd.com/read/25803612/the-nicotinic-receptor-alpha7-impacts-the-mouse-lung-response-to-lps-through-multiple-mechanisms
#6
Elena Y Enioutina, Elizabeth J Myers, Petr Tvrdik, John R Hoidal, Scott W Rogers, Lorise C Gahring
The nicotinic acetylcholine receptor alpha7 (α7) is expressed by neuronal and non-neuronal cells throughout the body. We examined the mechanisms of the lung inflammatory response to intranasal (i.n.) lipopolysaccharide (LPS) regulated by α7. This was done in mice using homologous recombination to introduce a point mutation in the α7 receptor that replaces the glutamate residue 260 that lines the pore with alanine (α7E260A), which has been implicated in controlling the exceptional calcium ion conductance of this receptor...
2015: PloS One
https://www.readbyqxmd.com/read/24945520/nicotine-effect-on-bone-remodeling-during-orthodontic-tooth-movement-histological-study-in-rats
#7
COMPARATIVE STUDY
Ricardo Lima Shintcovsk, Luégya Knop, Orlando Motohiro Tanaka, Hiroshi Maruo
INTRODUCTION: Nicotine is harmful to angiogenesis, osteogenesis and synthesis of collagen. OBJECTIVE: The aim of this study was to investigate the effect of nicotine on bone remodeling during orthodontic movement in rats. METHODS: Eighty male Wistar rats were randomly divided into three groups: Group C (control), group CM (with orthodontic movement) and group NM (nicotine with orthodontic movement) groups. The animals comprising groups C and CM received 0...
March 2014: Dental Press Journal of Orthodontics
https://www.readbyqxmd.com/read/24455064/effects-of-simultaneous-nicotine-and-alcohol-use-in-periodontitis-progression-in-rats-a-histomorphometric-study
#8
Daniel F Pereira Vasconcelos, Marco A Dias da Silva, Marcelo Rocha Marques, Cristina Gibilini, Any C Cardoso Guimarães Vasconcelos, Silvana Pereira Barros
OBJECTIVE: The aim of this study was to evaluate the effects of alcohol and nicotine, when used alone or simultaneously, on the alveolar bone loss area resulting from ligature-induced periodontitis in rats. STUDY DESIGN: Forty adult male rats received a cotton ligature in the first lower molar sulcular area, and the animals were randomly assigned to different treatments (n = 10, each group) including daily peritoneal injections of saline solution (group A), submitted to self-administration of alcohol 25% (group B), nicotine solution in concentration 0...
April 1, 2013: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/23841288/-the-effects-of-nicotine-on-bone-calcium-and-phosphorus-content-and-alkaline-phosphatase-activity-in-different-part-of-rat
#9
Haixia Zhao, Su Ma, Li Chen, Peihong Liu, Jing Xu, Lin Hou, Rui Chen, Chunlin Qin
OBJECTIVE: To analyze the effects of nicotine on the bone calcium and phosphorus content and alkaline phosphatase (ALP) activity in rat alveolar bone and mandible. METHODS: Twenty health male Wistar rats of five weeks of age were randomly assigned to two groups and received daily intraperitoneal injections for three months as follows: Saline solution for control group, nicotine 0.73 mg.kg-l.d-1 for experimental group. The bone calcium phosphorus content were detected by concentrated acid digestion method and the ALP activity was examined by improved Reddi method...
June 2013: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/23443505/nicotine-favors-osteoclastogenesis-in-human-periodontal-ligament-cells-co-cultured-with-cd4-t-cells-by-upregulating-il-1%C3%AE
#10
Li-Zheng Wu, Duo-Mo Duan, Ying-Feng Liu, Xin Ge, Zhi-Fei Zhou, Xiao-Jing Wang
Periodontitis, which is the main cause of tooth loss, is one of the most common chronic oral diseases in adults. Tooth loss is mainly a result of alveolar bone resorption, which reflects an increased osteoclast formation and activation. Osteoclast formation in periodontal tissue is a multistep process driven by osteoclastogenesis supporting cells such as human periodontal ligament (PDL) cells and CD4(+) T cells. Inflammatory cytokines, such as interleukin-1β (IL-1β), can induce osteoclastogenesis by affecting the expression of receptor activator of NF-κB ligand (RANKL) and osteoprotegerin (OPG) in human PDL cells...
April 2013: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/22115820/effects-of-nicotine-on-proliferation-and-osteoblast-differentiation-in-human-alveolar-bone-marrow-derived-mesenchymal-stem-cells
#11
COMPARATIVE STUDY
Beom-Su Kim, Su-Jin Kim, Hyung-Jin Kim, Seung-Jin Lee, Yoon-Jeong Park, Jun Lee, Hyung-Keun You
AIMS: Nicotine is a risk factor for various diseases, including osteoporosis, oral cancer, and periodontal disease. Numerous studies have elucidated the effects of nicotine on cell proliferation and differentiation. The purpose of this study was to determine the effects of nicotine on the proliferation and osteoblast differentiation of human alveolar bone marrow-derived mesenchymal stem cells (hABMMSCs). MAIN METHODS: In this study, we treated hABMMSCs with different doses (1 μM to 5 mM) of nicotine...
January 16, 2012: Life Sciences
https://www.readbyqxmd.com/read/22092666/treatment-of-experimental-periodontal-disease-with-antimicrobial-photodynamic-therapy-in-nicotine-modified-rats
#12
COMPARATIVE STUDY
Valdir Gouveia Garcia, Leandro Araújo Fernandes, Valmir Campos Macarini, Juliano Milanezi de Almeida, Thiago Marchi Martins, Alvaro Francisco Bosco, Maria José Hitomi Nagata, Joni Augusto Cirelli, Letícia Helena Theodoro
BACKGROUND: The aim of this study was to compare antimicrobial photodynamic therapy (aPDT) as an adjunctive treatment to scaling and root planing (SRP) for induced periodontitis in nicotine-modified rats. MATERIAL & METHODS: A total of 240 rats were evenly divided into two groups: C - saline solution treatment; N - nicotine treatment. Periodontal disease was induced in both groups at the first mandibular molar. After 7 days, the ligature was removed. All animals were submitted to SRP and were divided according to the following treatments: SRP - irrigation with saline solution; Toluidine Blue-O (TBO) - irrigation with phenothiazinium dye (100 μg/ml); LLLT - laser irradiation (660 nm; 0...
December 2011: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/21469287/-effect-of-tobacco-smoking-on-the-course-and-degree-of-advancement-inflammation-in-periodontal-tissue
#13
Rafał Rudzińiski
INTRODUCTION: The destructive periodontal disease is the result of a complex interaction between the subgingival microflora and nonbacterial factors, specifically host and environmental factors. Principal susceptibility factors are genetic conditions of the immunoinflammatory response but tobacco dependence might be the proper risk factor in periodontitis. The aim of the work was to qualify the influence of cotinine and 3'hydroxycotinine as the main metabolites of nicotine, on the course and degree of chronic periodontitis advancement, according to clinical parameters of the periodontium condition among generally healthy heavy smoking adults...
2010: Annales Academiae Medicae Stetinensis
https://www.readbyqxmd.com/read/21226404/cigarette-smoking-and-radiographic-alveolar-bone-height-and-density
#14
Liran Levin, Jonathan Levine
Smoking might produce an adverse effect on alveolar bone height and density, acting as a potential risk factor for alveolar bone loss. In the present study, smokers exhibited significantly lower bone density values than nonsmokers (p < or = 0.002). Bone measurements from the cemento-enamel-junction (CEJ) to the bone crest indicated a significantly greater distance from the CEJ to the alveolar bone crest among smokers (p < 0.0001). The distance from the CEJ to the alveolar bone crest positively correlated to the reported number of cigarettes smoked per day (p < 0...
November 2010: New York State Dental Journal
https://www.readbyqxmd.com/read/21189082/nicotine-induced-damage-affects-gingival-fibroblasts-in-the-gingival-tissue-of-rats
#15
Juliano Milanezi de Almeida, Alvaro Francisco Bosco, Samara Bonfante, Letícia Helena Theodoro, Maria José Hitomi Nagata, Valdir Gouveia Garcia
BACKGROUND: Very limited information is available from in vivo studies about whether smoking and/or nicotine affect gingival tissues in the absence of plaque. The purpose of this study is to evaluate the effect of the systemic administration of nicotine in the proliferation and counting of fibroblast-like cells in the gingival tissue of rats. METHODS: Thirty adult male Wistar rats were randomly assigned into two groups to receive subcutaneous injections of a saline solution (control group = group C) or nicotine solution (group N; 3 mg/kg) twice a day...
August 2011: Journal of Periodontology
https://www.readbyqxmd.com/read/20922084/nicotine-and-periodontal-tissues
#16
Ranjan Malhotra, Anoop Kapoor, Vishakha Grover, Sumit Kaushal
Tobacco use has been recognized to be a significant risk factor for the development and progression of periodontal disease. Its use is associated with increased pocket depths, loss of periodontal attachment, alveolar bone and a higher rate of tooth loss. Nicotine, a major component and most pharmacologically active agent in tobacco is likely to be a significant contributing factor for the exacerbation of periodontal diseases. Available literature suggests that nicotine affects gingival blood flow, cytokine production, neutrophil and other immune cell function; connective tissue turnover, which can be the possible mechanisms responsible for overall effects of tobacco on periodontal tissues...
January 2010: Journal of Indian Society of Periodontology
https://www.readbyqxmd.com/read/20727634/action-of-nicotine-and-ovariectomy-on-bone-regeneration-after-tooth-extraction-in-rats
#17
Giscard José Ribeiro Machado, Sheila Mônica Damásio Dias, Alvaro Fancisco Bosco, Tetuo Okamoto, João César Bedran de Castro, Rita Cássia Menegati Dornelles
PURPOSE: The purpose of this study was to evaluate the effects of nicotine and ovariectomy on alveolar bone regeneration after exodontias in rats. MATERIALS AND METHODS: For 30 days, sham ovariectomized (OVX)/NaCl, sham OVX/nicotine, OVX/NaCl, and OVX/nicotine animals were given 2 daily injections of saline or hemisulfate of nicotine. After this period, exodontic procedures were carried out and treatment continued up to the time of euthanasia on days 7 and 14 when the alveoli were removed for further analyses...
November 2010: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/20572916/micro-computerized-tomography-analysis-of-alveolar-bone-loss-in-ligature-and-nicotine-induced-experimental-periodontitis-in-rats
#18
Y-F Liu, L-A Wu, J Wang, L-Y Wen, X-J Wang
BACKGROUND AND OBJECTIVE: Nicotine reportedly is a risk factor for periodontitis, but accurate data regarding nicotine-induced alveolar bone loss is lacking. The aim of this study was to quantitatively assess alveolar bone loss in ligature- and nicotine-induced periodontitis in rats using micro-computerized tomography (micro-CT). MATERIAL AND METHODS: Thirty-six adult male rats were treated by placing silk ligatures around the cervixes of the right second maxillary molar; the contralateral tooth was untreated...
December 2010: Journal of Periodontal Research
https://www.readbyqxmd.com/read/19953955/-effects-of-nicotine-on-alveolar-bone-loss-in-experimental-periodontitis-in-rat-a-micro-computed-tomographic-analysis
#19
Liu Ying-feng, Wang Xiao-jing, Wang Qing-yu, Zhang Xiao, Wang Jun
OBJECTIVE: To establish the three-dimensional images of rat's alveolar bone and to evaluate the effects of nicotine on alveolar bone loss during the process of ligature-induced periodontitis with micro-computed tomography (micro-CT). METHODS: Thirty-six adult male SD rats received silk ligatures around the cervix of the right second maxillary molars. Then the animals were randomly assigned to three groups and received daily intraperitoneal injections as follows: group A (control), saline solution; group B, nicotine, 0...
June 2009: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
https://www.readbyqxmd.com/read/19570272/the-influence-of-tobacco-smoking-on-the-onset-of-periodontitis-in-young-persons
#20
Brian H Mullally
This paper reviews the evidence for cigarette smoking as a risk factor for the development of severe destructive periodontal disease in young adults. A high prevalence of cigarette smoking has been identified among young individuals with aggressive periodontitis and tobacco usage increases the risk of periodontal destruction most significantly in young populations. The effect appears to be dose related and is independent of levels of plaque accumulation. Young smokers have more alveolar bone loss and attachment loss than non smoking equivalents...
June 15, 2004: Tobacco Induced Diseases
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