Setareh Orth-Alampour, Nathalie Gayrard, Silvia Salem, Shruti Bhargava, Vera Jankowski, Bernard Jover, Cécile Notarnicola, Heidi Noels, Emiel P C van der Vorst, Christoph Kuppe, Michael Wolf, Claudia Goettsch, Wendy Theelen, Heike Bruck, Danilo Fliser, Joseph Loscalzo, Zhuojun Wu, Nikolaus Marx, Walter Zidek, Àngel Argilés, Joachim Jankowski
The adrenal glands participate in cardiovascular (CV) physiology and the pathophysiology of CV diseases through their effects on sodium and water metabolism, vascular tone and cardiac function. In the present study, we identified a new adrenal compound controlling mesenchymal cell differentiation that regulates osteoblastic differentiation in the context of vascular calcification. This peptide was named the "calcification blocking factor" (CBF) due to its protective effect against vascular calcification and is released from chromogranin A via enzymatic cleavage by calpain 1 and kallikrein...
October 13, 2021: Basic Research in Cardiology