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https://www.readbyqxmd.com/read/29777633/hypertrophic-effect-of-inhaled-beta-2-agonist-with-and-without-concurrent-exercise-training-a-randomized-controlled-trial
#1
Søren Jessen, Johan Onslev, Anders Lemminger, Vibeke Backer, Jens Bangsbo, Morten Hostrup
INTRODUCTION: Due to a high prevalence of asthma and exercise-induced bronchoconstriction in elite athletes, there is a high use of beta2 -adrenoceptor agonists (beta2 -agonists) in the athletic population. While anabolic in rodents, no study has been able to detect hypertrophy in humans after chronic beta2 -agonist inhalation. METHODS: We investigated if inhaled beta2 -agonist, terbutaline, alters body composition and metabolic rate with and without concurrent exercise training in healthy young men...
May 19, 2018: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/29776902/an-internet-based-radiology-course-in-medical-school-comparison-of-academic-performance-of-students-on-campus-versus-those-with-absenteeism-due-to-residency-interviews
#2
Andrew George Alexander, Deborah Deas, Paul Eric Lyons
BACKGROUND: Imaging and its optimal use are imperative to the practice of medicine, yet many students don't receive a formal education in radiology. Concurrently, students look for ways to take time away from medical school for residency interviewing. Web-based instruction provides an opportunity to combine these imperatives using online modalities. OBJECTIVE: A largely Web-based course in radiology during the 4th year of medical school was evaluated both for its acceptance to students who needed to be away from campus for interviews, and its effectiveness on a nationally administered standardized test...
May 18, 2018: JMIR Medical Education
https://www.readbyqxmd.com/read/29775322/prediction-of-human-cytochrome-p450-inhibition-using-a-multi-task-deep-autoencoder-neural-network
#3
Xiang Li, Youjun Xu, Luhua Lai, Jianfeng Pei
Adverse side effects of drug-drug interactions induced by human cytochrome P450 (CYP450) inhibition is an important consideration in drug discovery. It is highly desirable to develop computational models that can predict the inhibitive effect of a compound against a specific CYP450 isoform. In this study, we developed a multi-task model for concurrent inhibition prediction of five major CYP450 isoforms, namely 1A2, 2C9, 2C19, 2D6, and 3A4. The model was built by training multi-task autoencoder deep neural network (DNN) on a large dataset containing more than 13000 compounds, extracted from PubChem BioAssay Database...
May 18, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29775287/computational-prediction-and-analysis-for-tyrosine-post-translational-modifications-via-elastic-net
#4
Man Cao, Guodong Chen, Lina Wang, Pingping Wen, Shaoping Shi
The tyrosine residue has been identified as suffering three major post-translational modifications (PTMs) including nitration, sulfation, and phosphorylation, which could be involved in different physiological and pathological processes. Multiple tyrosine residues of the whole protein may be modified concurrently, where PTM of a single tyrosine may affect modification of other neighboring tyrosine residues. Hence, it is significant and beneficial to predict nitration, sulfation, and phosphorylation of tyrosine residues in the whole protein sequence...
May 18, 2018: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/29771669/suboptimal-scheduling-in-switched-systems-with-continuous-time-dynamics-a-least-squares-approach
#5
Tohid Sardarmehni, Ali Heydari
Two approximate solutions for optimal control of switched systems with autonomous subsystems and continuous-time dynamics are presented. The first solution formulates a policy iteration (PI) algorithm for the switched systems with recursive least squares. To reduce the computational burden imposed by the PI algorithm, a second solution, called single loop PI, is presented. Online and concurrent training algorithms are discussed for implementing each solution. At last, effectiveness of the presented algorithms is evaluated through numerical simulations...
June 2018: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/29769816/the-effect-of-two-different-concurrent-training-programs-on-strength-and-power-gains-in-highly-trained-individuals
#6
Henrik Petré, Pontus Löfving, Niklas Psilander
The effects of concurrent strength and endurance training have been well studied in untrained and moderately-trained individuals. However, studies examining these effects in individuals with a long history of resistance training (RT) are lacking. Additionally, few studies have examined how strength and power are affected when different types of endurance training are added to an RT protocol. The purpose of the present study was to compare the effects of concurrent training incorporating either low-volume, high-intensity interval training (HIIT, 8-24 Tabata intervals at ~150% of VO2max ) or high-volume, medium-intensity continuous endurance training (CT, 40-80 min at 70% of VO2max ), on the strength and power of highly-trained individuals...
June 2018: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/29766539/block-versus-longitudinal-integrated-clerkships-students-views-of-rural-clinical-supervision
#7
Martin Witney, Vivian Isaac, Denese Playford, Leesa Walker, David Garne, Lucie Walters
CONTEXT: Medical students undertaking longitudinal integrated clerkships (LICs) train in multiple disciplines concurrently, compared with students in block rotations who typically address one medical discipline at a time. Current research suggests that LICs afford students increased access to patients and continuity of clinical supervision. However, these factors are less of an issue in rural placements where there are fewer learners. The aim of this study was to compare rural LIC and rural block rotation students' reported experiences of clinical supervision...
May 15, 2018: Medical Education
https://www.readbyqxmd.com/read/29759262/focus-on-the-quadruple-aim-development-of-a-resiliency-center-to-promote-faculty-and-staff-wellness-initiatives
#8
Ellen Morrow, Megan Call, Robin Marcus, Amy Locke
DEFINING THE PROBLEM: A growing body of evidence highlights the need for wellness programs to support health care professionals. Although much of the existing literature centers on practicing physicians and physician trainees, there is growing awareness that these challenges are not unique to physicians and affect all members of the health care team. Traumatic and stressful events will always be a part of health care; how these events are addressed on a personal and team level is essential to the success of a health care system...
May 2018: Joint Commission Journal on Quality and Patient Safety
https://www.readbyqxmd.com/read/29754533/the-validation-of-a-swimming-turn-wall-contact-time-measurement-system-a-touchpad-application-reliability-study
#9
Victoria Brackley, Kevin Ball, Elaine Tor
The effectiveness of the swimming turn is highly influential to overall performance in competitive swimming. The push-off or wall contact, within the turn phase, is directly involved in determining the speed the swimmer leaves the wall. Therefore, it is paramount to develop reliable methods to measure the wall-contact-time during the turn phase for training and research purposes. The aim of this study was to determine the concurrent validity and reliability of the Pool Pad App to measure wall-contact-time during the freestyle and backstroke tumble turn...
May 12, 2018: Sports Biomechanics
https://www.readbyqxmd.com/read/29749663/inter-individual-responses-to-different-exercise-stimuli-among-insulin-resistant-women
#10
C Álvarez, R Ramírez-Vélez, R Ramírez-Campillo, I Shigenori, C Celis-Morales, A García-Hermoso, L Rodriguez-Mañas, A Lucia, M Izquierdo
We aimed to investigate which among 20-cardiometabolic and performance outcomes do and do not respond to high-intensity interval training (HIT), resistance training (RT), or concurrent training (CT) in insulin-resistant adult women. A secondary aim was to report the training-induced changes and the prevalence of non-responders. Forty-five insulin-resistant adult women were randomly assigned to one of the following four groups: HIT (39.2±9.5 years [y]; body mass index [BMI], 29.3±3.3; n=14), RT (33.9±9.3 y; BMI, 29...
May 11, 2018: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/29744861/low-serum-cholesterol-levels-predict-inferior-prognosis-and-improve-nccn-ipi-scoring-in-diffuse-large-b-cell-lymphoma
#11
Rui Gao, Jin-Hua Liang, Li Wang, Hua-Yuan Zhu, Wei Wu, Lei Cao, Lei Fan, Jian-Yong Li, Tao Yang, Wei Xu
Low circulating cholesterol concentration is associated with elevated cancer incidence and mortality. However, the association between cholesterol levels and diffuse large B cell lymphoma (DLBCL) remains unknown. The aim of our study was to evaluate the prognostic value of serum lipid profile in DLBCL. Five hundred and fifty enrolled subjects with detailed serum lipid levels at diagnosis of DLBCL were randomly divided into a training set (n=367) and a validation set (n=183) (ratio, 2:1). Multivariate Cox regression analyses screened the prognostic factors associated with progression-free survival (PFS) and overall survival (OS)...
May 9, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29743051/the-effectiveness-and-feasibility-of-treat-tailoring-research-evidence-and-theory-journal-clubs-in-allied-health-a-randomised-controlled-trial
#12
Rachel J Wenke, Rae Thomas, Ian Hughes, Sharon Mickan
BACKGROUND: Journal clubs (JC) may increase clinicians' evidence-based practice (EBP) skills and facilitate evidence uptake in clinical practice, however there is a lack of research into their effectiveness in allied health. We investigated the effectiveness of a structured JC that is Tailored According to Research Evidence And Theory (TREAT) in improving EBP skills and practice compared to a standard JC format for allied health professionals. Concurrently, we explored the feasibility of implementing TREAT JCs in a healthcare setting, by evaluating participating clinicians' perceptions and satisfaction...
May 9, 2018: BMC Medical Education
https://www.readbyqxmd.com/read/29726002/robust-and-accurate-decoding-of-motoneuron-behavior-and-prediction-of-the-resulting-force-output
#13
Christopher K Thompson, Francesco Negro, Michael D Johnson, Matthew R Holmes, Laura Miller McPherson, Randall K Powers, Dario Farina, Charles J Heckman
KEY POINTS SUMMARY: The spinal alpha motoneuron is the only cell in the human CNS whose discharge can be routinely recorded in humans. We have reengineered motor unit collection and decomposition approaches, originally developed in humans, to measure the neural drive to muscle and estimate muscle force generation in the decerebrate cat model. Experimental, computational, and predictive approaches are used to demonstrate the validity of this approach across a wide range of modes to activate the motor pool...
May 3, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29723637/multidimensional-co-segmentation-of-longitudinal-brain-mri-ensembles-in-the-presence-of-a-neurodegenerative-process
#14
Shiri Gordon, Irit Dolgopyat, Itamar Kahn, Tammy Riklin Raviv
MRI Segmentation of a pathological brain poses a significant challenge, as the available anatomical priors that provide top-down information to aid segmentation are inadequate in the presence of abnormalities. This problem is further complicated for longitudinal data capturing impaired brain development or neurodegenerative conditions, since the dynamic of brain atrophies has to be considered as well. For these cases, the absence of compatible annotated training examples renders the commonly used multi-atlas or machine-learning approaches impractical...
April 30, 2018: NeuroImage
https://www.readbyqxmd.com/read/29720935/brain-oscillatory-and-hemodynamic-activity-in-a-bimanual-coordination-task-following-transcranial-alternating-current-stimulation-tacs-a-combined-eeg-fnirs-study
#15
Alisa Berger, Nils H Pixa, Fabian Steinberg, Michael Doppelmayr
Motor control is associated with synchronized oscillatory activity at alpha (8-12 Hz) and beta (12-30 Hz) frequencies in a cerebello-thalamo-cortical network. Previous studies demonstrated that transcranial alternating current stimulation (tACS) is capable of entraining ongoing oscillatory activity while also modulating motor control. However, the modulatory effects of tACS on both motor control and its underlying electro- and neurophysiological mechanisms remain ambiguous. Thus, the purpose of this study was to contribute to gathering neurophysiological knowledge regarding tACS effects by investigating the after-effects of 10 Hz tACS and 20 Hz tACS at parietal brain areas on bimanual coordination and its concurrent oscillatory and hemodynamic activity...
2018: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/29719725/the-incidence-of-injury-in-elite-camogie-an-in-season-prospective-study
#16
Catherine Susan Buckley, Catherine Blake
Background: Camogie is a stickhandling, high-velocity, multidirectional field sport for females which is native to Ireland, but is also played internationally. Aim: To establish the incidence, nature and severity of injuries in elite camogie players. Methods: A prospective, observational cohort study was carried out during the Provincial Championships and extending into the All-Ireland Championship until a participating team was eliminated (11 weeks)...
2018: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/29718968/acute-attenuation-of-fatigue-after-sodium-bicarbonate-supplementation-does-not-manifest-into-greater-training-adaptations-after-10-weeks-of-resistance-training-exercise
#17
Jason C Siegler, Paul W M Marshall, Harrison Finn, Rebecca Cross, Kurt Mudie
PURPOSE: In two concurrent studies, we aimed to a) confirm the acute effect of 0.3 g·kg-1 body weight (BW) sodium bicarbonate (NaHCO3) supplementation on central and peripheral mechanisms associated with explosive power (Study 1) and b) determine whether chronic NaHCO3 supplementation would improve the adaptive response of the neuromuscular system during a 10-week resistance training program (Study 2). METHODS: Eight resistance trained participants volunteered after providing written consent...
2018: PloS One
https://www.readbyqxmd.com/read/29704600/effects-of-internal-and-external-factors-on-the-budgeting-between-defensive-and-non-defensive-responses-in-aplysia
#18
Kaitlyn A Mac Leod, Alexandra Seas, Marcy L Wainwright, Riccardo Mozzachiodi
Following exposure to aversive stimuli, organisms budget their behaviors by augmenting defensive responses and reducing/suppressing non-defensive behaviors. This budgeting process must be flexible to accommodate modifications in the animal's internal and/or external state that require the normal balance between defensive and non-defensive behaviors to be adjusted. When exposed to aversive stimuli, the mollusk Aplysia budgets its behaviors by concurrently enhancing defensive withdrawal reflexes (an elementary form of learning known as sensitization) and suppressing feeding...
April 25, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29704524/differential-effects-of-high-frequency-transcranial-random-noise-stimulation-hf-trns-on-contrast-sensitivity-and-visual-acuity-when-combined-with-a-short-perceptual-training-in-adults-with-amblyopia
#19
Beatrice Moret, Rebecca Camilleri, Andrea Pavan, Giuseppe Lo Giudice, Antonella Veronese, Roberta Rizzo, Gianluca Campana
Amblyopia is a neuro-developmental disorder characterised by several functional impairments in spatial vision even with the best optical correction. There is evidence that extensive perceptual training can improve visual acuity (VA) and contrast sensitivity (CS) in adults with amblyopia. In the present study, we assessed the efficacy of a recently developed neuro-modulatory technique (i.e., high-frequency transcranial random noise stimulation; hf-tRNS) combined with a short perceptual training in adults with amblyopia...
April 25, 2018: Neuropsychologia
https://www.readbyqxmd.com/read/29704398/the-effect-of-ipc-on-central-and-peripheral-fatiguing-mechanisms-in-humans-following-sustained-maximal-isometric-exercise
#20
Samuel L Halley, Paul Marshall, Jason C Siegler
NEW FINDINGS: What is the central question of this study? Does ischemic preconditioning (IPC) influence central and peripheral fatiguing mechanisms during sustained maximal isometric exercise? What is the main finding and its importance? Voluntary activation and pre- to post-exercise reductions in resting twitch torque values were unchanged by IPC. However, an effect on tissue oxygenation was observed within the IPC trials where greater concentrations of deoxyhaemoglobin were recorded with concurrent upward trends of total haemoglobin concentrations...
April 28, 2018: Experimental Physiology
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