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Neil Waldman, Ben Winrow, Ian Densie, Andrew Gray, Scott McMaster, George Giddings, John Meanley
STUDY OBJECTIVE: To determine if the number of emergency department (ED) rechecks, persistent fluorescein uptake, ophthalmology referrals, or complications would be affected by the prescription of topical tetracaine for pain relief from simple corneal abrasions (SCAs). METHODS: This retrospective cohort study was conducted in an ED where policy change allowed physicians to use topical tetracaine hydrochloride 1% eye drops for 24 hours for pain treatment for patients with corneal abrasions...
May 2, 2017: Annals of Emergency Medicine
Jason P Shurley, Janice S Todd, Terry C Todd
Shurley, JP, Todd, JS, and Todd, TC. The science of strength: reflections on the National Strength and Conditioning Association and the emergence of research-based strength and conditioning. J Strength Cond Res 31(2): 517-530, 2017-The National Strength and Conditioning Association (NSCA) formed in 1978 when a group of 76 strength and conditioning coaches banded together to start an organization whose goal was to facilitate the exchange of ideas on strength training for sports. At the time, very little research existed regarding strength training protocols or their effects...
February 2017: Journal of Strength and Conditioning Research
Yanhua Fan, Jianyu Liu, Dan Liu, Zhipeng Zhou, Ying Bao, Jian Wang, Qingchun Zhao, Yongnan Xu
Coumalamide derivatives are one of 2-pyrones derivatives, exerting multifunctional bioactivity. An array of coumalamide derivatives have been developed and presented good antiproliferative properties on cancer cells. However, the synthesis of 5-substituted coumalamide derivatives has not yet been published. Resistance to chemotherapeutic drugs is a major obstacle in hepatocellular carcinoma therapy. Recent evidence suggests that overexpression of constitutively active Akt confers on cancer cells resistance to chemotherapy...
January 2017: Environmental Toxicology and Pharmacology
S I Jaja, S O Ogungbemi, M O Kehinde, C N Anigbogu
The effect of l-arginine on liver function in SCD has received little or no attention. The effect of a chronic, oral, low-dose supplementation with l-arginine (1gm/day for 6 weeks) on some liver enzymes, lipid peroxidation and nitric oxide metabolites was studied in 20 normal (non-sickle cell anaemia; NSCA) subjects and 20 sickle cell anaemia (SCA) subjects. Ten milliliters of blood was withdrawn from an ante-cubital vein for the estimation of plasma arginine concentration ([R]), alanine aminotransaminase (ALT), aspartate aminotransaminase (AST) and alkaline phosphatase (ALP), plasma total bilirubin concentration [TB], malondialdehyde concentration [MDA] and nitric oxide metabolites concentration [NOx]...
June 2016: Pathophysiology: the Official Journal of the International Society for Pathophysiology
Rhodri S Lloyd, John B Cronin, Avery D Faigenbaum, G Gregory Haff, Rick Howard, William J Kraemer, Lyle J Micheli, Gregory D Myer, Jon L Oliver
There has recently been a growing interest in long-term athletic development for youth. Because of their unique physical, psychological, and social differences, children and adolescents should engage in appropriately prescribed exercise programs that promote physical development to prevent injury and enhance fitness behaviors that can be retained later in life. Irrespective of whether a child is involved in organized sport or engages in recreational physical activity, there remains a need to adopt a structured, logical, and evidence-based approach to the long-term development of athleticism...
June 2016: Journal of Strength and Conditioning Research
Jordan J Outlaw, Abbie E Smith-Ryan, Amanda L Buckley, Stacie L Urbina, Sara Hayward, Hailee L Wingfield, Bill Campbell, Cliffa Foster, Lem W Taylor, Colin D Wilborn
Outlaw, JJ, Smith-Ryan, AE, Buckley, AL, Urbina, SL, Hayward, S, Wingfield, HL, Campbell, B, Foster, C, Taylor, LW, and Wilborn, CD. Effects of β-alanine on body composition and performance measures in collegiate women. J Strength Cond Res 30(9): 2627-2637, 2016-The purpose of this study was to evaluate the effects of β-alanine (BA) supplementation and resistance training on body composition and performance. In a double-blind placebo-controlled design, 16 untrained collegiate females (mean ± SD: 21.0 ± 2...
September 2016: Journal of Strength and Conditioning Research
Jordan D Chambers, Joel C Bornstein, Rachel M Gwynne, Katerina Koussoulas, Evan A Thomas
Intrinsic sensory neurons (ISNs) of the enteric nervous system respond to stimuli such as muscle tension, muscle length, distortion of the mucosa, and the chemical content in the lumen. ISNs form recurrent networks that probably drive many intestinal motor patterns and reflexes. ISNs express a large number of voltage- and calcium-gated ion channels, some of which are modified by inflammation or repeated physiological stimuli, but how interactions between different ionic currents in ISNs produce both normal and pathological behaviors in the intestine remains unclear...
September 1, 2014: American Journal of Physiology. Gastrointestinal and Liver Physiology
Alexander Egbe, Simon Lee, Deborah Ho, Santosh Uppu, Shubhika Srivastava
BACKGROUND: There is a known association between congenital heart disease (CHD) and other congenital anomalies (CA). These associations have been altered by changes in prenatal factors in recent time. We reviewed the largest database of inpatient hospitalization information and analyzed the current association between common CHD diagnoses and other congenital anomalies. MATERIALS AND METHODS: Case-control study design. We reviewed the Nationwide Inpatient Sample (NIS) database from 1998 to 2008 and identified all live births with CHD diagnosis (case) and live births without CHD diagnosis (control)...
May 2014: Annals of Pediatric Cardiology
M Dahal, P Kumar, G K Singh, S S Arora, M P Singh
Objectives: The present study presents the technique to predict cubitus varus by post reduction Affected Side and Normal Side Baumann's angle difference (ASBA and NSBA) respectively. It intends to correlate the Baumann's angle to the final carrying angle of the injured elbow and presents the relevant mathematical clinical rule along with its prediction test characteristics. Material and Methods: Total 57 patients of 6.5±1.67yrs, 22 were males and 8 females with 19/30 having left side injury. Isolated closed supracondylar fractures of humerus up to 5 days duration included and previous trauma, pathological fracture, other injury, elbow disease were excluded ...
April 2006: Kathmandu University Medical Journal (KUMJ)
S I Ogungbemi, C N Anigbogu, M O Kehinde, S I Jaja
Pressor and heart rate changes following change in posture without or with L-arginine supplementation (1g/day for 6 weeks) were studied in 28 sickle cell anemia (SCA) and 32 non-sickle cell anemia (NSCA) subjects. Change in posture increased HR (p<0.01), RPP (p<0.05) in both groups of subjects, MABP (p<0.05) in SCAS but reduced MABP (p<0.01) in NSCAS and PP (p<0.01) in SCAS. L-Arginine supplementation increased plasma L-Arginine concentration ([R]) in both groups of subjects (p<0.001 in each group) and serum nitric oxide metabolites concentration ([NOx]) (p<0...
2013: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
Sravan Mandadi, Peter Hong, Michelle A Tran, Joao M Bráz, Pina Colarusso, Allan I Basbaum, Patrick J Whelan
Compared to proprioceptive afferent collateral projections, less is known about the anatomical, neurochemical, and functional basis of nociceptive collateral projections modulating lumbar central pattern generators (CPG). Quick response times are critical to ensure rapid escape from aversive stimuli. Furthermore, sensitization of nociceptive afferent pathways can contribute to a pathological activation of motor circuits. We investigated the extent and role of collaterals of capsaicin-sensitive nociceptive sacrocaudal afferent (nSCA) nerves that directly ascend several spinal segments in Lissauer's tract and the dorsal column and regulate motor activity...
August 15, 2013: Journal of Comparative Neurology
Jae-Hun Lee, Hyun Seok Song, Tai Hyun Park, Tae Hyun Park, Sun-Gu Lee, Byung-Gee Kim
Cell-penetrating peptides (CPPs) are attractive vectors for in vivo and in vitro cellular uptake. Their use is, however, limited by insufficient understanding of their preference for a target cell. Here, a new CPP screening method is presented that uses mRNA display. After incubating the target cell lines, such as human embryonic kidney 293 (HEK 293) and HeLa cells, with an mRNA display library for 3 h at 37°C, the CPP-mRNA nucleotide conjugates were harvested. These were amplified with PCR and subsequently sequenced...
March 2012: Biotechnology Journal
M O Kehinde, S I Jaja, O M Adewumi, I M Adeniyi, M O Nezianya, E O Ayinla
BACKGROUND: Trace elements are required for the performance of numerous functions of immune cells. It is not clear whether levels of trace elements are elevated and whether there is a relationship between the levels of liver enzymes and trace elements in patients with sickle cell anaemia in crisis. OBJECTIVE: To compare the plasma levels of liver enzymes and trace elements in non sickle cell anaemia (NSCA), sickle cell anaemia subjects in the steady state (SCASS) and sickle cell anaemia patients in crisis (SCAC)...
July 2010: West African Journal of Medicine
Jay R Hoffman, William J Kraemer, Shalender Bhasin, Thomas Storer, Nicholas A Ratamess, G Gregory Haff, Darryn S Willoughby, Alan D Rogol
Hoffman, JR, Kraemer, WJ, Bhasin, S, Storer, T, Ratamess, NA, Haff, GG, Willoughby, DS, and Rogol, AD. Position stand on Androgen and human growth hormone use. J Strength Cond Res 23(5): S1-S59, 2009-Perceived yet often misunderstood demands of a sport, overt benefits of anabolic drugs, and the inability to be offered any effective alternatives has fueled anabolic drug abuse despite any consequences. Motivational interactions with many situational demands including the desire for improved body image, sport performance, physical function, and body size influence and fuel such negative decisions...
August 2009: Journal of Strength and Conditioning Research
Avery D Faigenbaum, William J Kraemer, Cameron J R Blimkie, Ian Jeffreys, Lyle J Micheli, Mike Nitka, Thomas W Rowland
Faigenbaum, AD, Kraemer, WJ, Blimkie, CJR, Jeffreys, I, Micheli, LJ, Nitka, M, and Rowland, TW. Youth resistance training: Updated position statement paper from the National Strength and Conditioning Association. J Strength Cond Res 23(5): S60-S79, 2009-Current recommendations suggest that school-aged youth should participate daily in 60 minutes or more of moderate to vigorous physical activity that is developmentally appropriate and enjoyable and involves a variety of activities (). Not only is regular physical activity essential for normal growth and development, but also a physically active lifestyle during the pediatric years may help to reduce the risk of developing some chronic diseases later in life ()...
August 2009: Journal of Strength and Conditioning Research
M Dahal, P Kumar, G K Singh, S S Arora, M P Singh
OBJECTIVES: The present study presents the technique to predict cubitus varus by post reduction Affected Side and Normal Side Baumann's angle difference (ASBA and NSBA) respectively. It intends to correlate the Baumann's angle to the final carrying angle of the injured elbow and presents the relevant mathematical clinical rule along with its prediction test characteristics. MATERIAL AND METHODS: Total 57 patients of 6.5+/-1.67 yrs, 22 were males and 8 females with 19/30 having left side injury...
April 2006: Kathmandu University Medical Journal (KUMJ)
S I Jaja, M O Kehinde, S I Ogungbemi
Autonomic function following change in posture with or without vitamin C supplementation was studied in ten (10) sickle cell anemia (SCA) and twelve (12) non-sickle cell anemia (NSCA) subjects. Arterial blood pressure and electrocardiographic measurements were taken in the supine position on a couch 80cm high and immediately on assumption of the upright position. Vitamin C was then administered orally (300mg/day for 6 weeks). At the end of the period, blood pressure and ECG measurements were again made in the supine position and in response to change in posture...
June 2008: Pathophysiology: the Official Journal of the International Society for Pathophysiology
Julie N Garver, Kristine Z Jankovitz, Jane M Danks, Ashley A Fittz, Heather S Smith, Steven C Davis
Both industrial and municipal firefighters need to maintain high levels of physical fitness and minimize cardiovascular risk factors. The nature of firefighter responsibilities in industrial and municipal settings may vary, affecting the ability to sustain high levels of physical fitness. We compared the working conditions, physical fitness, and exercise training practices of an industrial fire department (n = 17) to those of a nearby municipal fire department (n = 55). After informed consent, aerobic capacity, muscular strength, muscular endurance, body composition, flexibility, blood lipid concentrations, and blood pressure levels were measured...
May 2005: Journal of Strength and Conditioning Research
Jason D Vescovi, Helen M Binkley, Chad M Kerksick
The Education Recognition Program (ERP) was developed to acknowledge academic institutions meeting departmental criteria established by the National Strength and Conditioning Association (NSCA) for having an area of concentration in undergraduate strength and conditioning. Since its inception, over 40 universities have received recognition status. The NSCA is currently examining the interest, need, and feasibility of creating an ERP for graduate curriculum specific to sports performance. The current investigation included a survey of Division I, II, and III strength and conditioning professionals...
May 2004: Journal of Strength and Conditioning Research
Hsi-Hsien Yang, Lien-Te Hsieh, Min-Ching Lin, Hsiao-Hsuan Mi, Pei-Chuan Chen
Sulfate-containing aerosol (SCA) dry deposition at the highway intersection, coastal location, and suburban area in Taiwan were analyzed and compared. Sampling was accomplished with a surrogate surface technique. Samples particles were coated with barium chloride (BaCl(2)) in a vacuum evaporator and then exposed to a relative humidity of 85% for 2 h to form distinctive products of SCAs. Treated samples were examined by a scanning electron microscopy. SCA dry deposition fluxes were 10.2, 4.1, 3.4 microgm(-2)s(-1) and nonsulfate-containing aerosol (NSCA) dry deposition fluxes were 23...
January 2004: Chemosphere
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