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hscrp and metabolic syndrome

Ramona Stroescu, Teofana Bizerea, Gabriela Doroş, Monica Marazan, Maria Lesovici, Otilia Mãrginean
Objective: To investigate the relationship between markers of adiposity and common carotid artery (CIMT) in obese children born small for gestational age (SGA) versus appropriate for gestational age (AGA), to establish cut-off values for CIMT in obese pediatric populations. Subjects and methods: A cross-sectional study was carried out over a 1-year period (Jul 2013 - June 2014). We analyzed 122 obese patients aged 4-20 (mean age 14.9 ± 2.28). Twenty-six patients were born SGA...
September 5, 2016: Archives of Endocrinology and Metabolism
Anna Polus, Barbara Zapala, Urszula Razny, Anna Gielicz, Beata Kiec-Wilk, Malgorzata Malczewska-Malec, Marek Sanak, Caroline E Childs, Philip C Calder, Aldona Dembinska-Kiec
The n-3 polyunsaturated fatty acids (PUFAs) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) may reduce low-grade inflammation associated with obesity. The relationship between therapeutic response to n-3 PUFAs and modification of the transcriptome in obesity or metabolic syndrome remains to be explored. Blood samples were obtained from women with obesity before and after three-months supplementation with a moderate dose of n-3 PUFAs (1.8g EPA+DHA per day) or from controls. n-3 PUFAs (GC) and plasma concentrations of lipoxins, resolvins, protectin X (GC-MS/MS) and inflammatory markers (ELISA) were measured...
August 12, 2016: Biochimica et Biophysica Acta
Rumyana Dimova, Tsvetalina Tankova, Georgi Kirilov, Nevena Chakarova, Lilia Dakovska, Greta Grozeva
BACKGROUND: This study aims to assess serum vaspin in early stages of glucose intolerance and in the presence of metabolic syndrome (MetS); and to evaluate vaspin correlation to different cardio-metabolic parameters and autonomic tone in these subjects. METHODS: 185 subjects (80 males and 105 females) of mean age 45.8 ± 11.6 years and mean BMI 31.2 ± 6.3 kg/m(2), divided into groups according to: glucose tolerance, presence of MetS and cardio-vascular autonomic dysfunction (CAD), were enrolled...
2016: Diabetology & Metabolic Syndrome
Juma Alkaabi, Salah Gariballa, Charu Sharma, Javed Yasin, Awad Al Essa, Habiba Ali, Abdul-Kader Souid
BACKGROUND: The prevalence of abdominal obesity among women in UAE is exceptionally high. However, its impact on cardiovascular health has not been adequately investigated. The aims of this study were to investigate: (1) correlations between inflammatory and oxidative biomarkers vs. anthropometric and metabolic measures; (2) rates of dyslipidemia, diabetes, and hypertension and (3) risks of cardiovascular disease. METHODS: One hundred ten "healthy" overweight/obese Emirati women attending nutrition counselling clinics were randomly recruited...
2016: BMC Research Notes
Sandra Maria Barbalho, Marcelo Dib Bechara, Ricardo José Tofano, Karina Quesada, Claudemir Gregório Mendes, Marie Oshiiwa
BACKGROUND: The Metabolic Syndrome (MS) is characterized by a set of risk factors, which causes metabolic and inflammatory changes that increase vascular risk and may promote the development of atherosclerosis. Changes in lifestyle are related to obesity and associated diseases such as hypertension, type 2 diabetes mellitus, MS and cardiovascular disease (CVD). AIMS: This study aimed to evaluate the relationship of MS components and high sensitivity C Reactive Protein (hsCRP) in patients undergoing arteriography...
June 18, 2016: Diabetes & Metabolic Syndrome
Chrysanthi Papanastasopoulou, Maria Papastamataki, Petros Karampatsis, Eleni Anagnostopoulou, Ioannis Papassotiriou, Nikolaos Sitaras
BACKGROUND: Hyaluronic acid (HA) has been found to be an important trigger of atherosclerosis. In this study, we investigate the possible association of serum HA with cardiovascular disease risk in a population of low/intermediate risk for cardiovascular events. METHODS: We enrolled 200 subjects with low/intermediate risk for developing cardiovascular disease. High specific C-reactive protein (hsCRP) was used as an indicator of preclinical atherosclerosis. The Framingham score was used to calculate the cardiovascular risk...
June 16, 2016: Journal of Clinical Laboratory Analysis
Radana Gurecká, Ivana Koborová, Melinda Csongová, Jozef Šebek, Katarína Šebeková
In non-diabetics, low levels of soluble receptor for advanced glycations end products (sRAGE) associate with an increased risk of development of diabetes, cardiovascular afflictions, or death. The majority of studies in non-diabetics report an inverse relationship between measures of obesity, cardiometabolic risk factors and sRAGE and/or endogenous secretory RAGE (esRAGE) levels. To elucidate whether this inconsistency is related to the metabolically healthy obese phenotype, or a different impact of the risk factors in presence and absence of obesity, we analyzed data from 2206 apparently healthy adolescents (51 % girls) aged 15-to-19 years...
August 2016: Glycoconjugate Journal
Juliane Menzel, Romina di Giuseppe, Ronald Biemann, Clemens Wittenbecher, Krasimira Aleksandrova, Tobias Pischon, Andreas Fritsche, Matthias B Schulze, Heiner Boeing, Berend Isermann, Cornelia Weikert
BACKGROUND AND AIMS: The recently identified adipokine omentin-1 is inversely associated with body fatness, metabolic syndrome and cardiovascular disease (CVD) in cross-sectional analyses. However, prospective data on the association between plasma omentin-1 levels and future risk of CVD are lacking. The aim of the study was to investigate the relationship between omentin-1 and incident myocardial infarction (MI) and stroke. METHODS: We conducted a case-cohort study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam cohort comprising a subsample of 2084 participants, including 50 CVD cases and 350 external incident CVD cases (mean follow-up of 8...
August 2016: Atherosclerosis
Eke G Gruppen, Margery A Connelly, Robin P F Dullaart
BACKGROUND: Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a cardiovascular risk marker, which is in part complexed to low-density lipoproteins, where it exerts pro-inflammatory properties. GlycA is a pro-inflammatory proton nuclear magnetic resonance spectroscopy biomarker whose signal originates from a subset of N-acetylglucosamine residues on the most abundant glycosylated acute-phase proteins. OBJECTIVE: We compared plasma GlycA and Lp-PLA2 mass between subjects without type 2 diabetes mellitus (T2DM) or the metabolic syndrome (MetS) and subjects with T2DM and/or MetS...
May 2016: Journal of Clinical Lipidology
Israt Ara Hossain, Salima Akter, Farjana Rahman Bhuiyan, Mijanur Rahman Shah, Mohammad Khalilur Rahman, Liaquat Ali
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is a metabolic disease commonly associated with obesity, type 2 diabetes, and inflammation-all features of insulin resistant syndrome. However, very limited data are available regarding the association of subclinical inflammation and insulin resistance with NAFLD in a prediabetic state. We, therefore, conducted the study to assess this relationship among this population. METHODS: We studied a cross-sectional analytical design of 140 [male/female, 77/63; age in years (ranges), 45 (25-68)] prediabetic subjects after confirming with 75 g oral glucose tolerance test...
2016: BMC Research Notes
Segundo Á Gómez-Abril, Carlos Morillas-Ariño, Jose L Ponce-Marco, Teresa Torres-Sánchez, Fernando Delgado-Gomis, Antonio Hernández-Mijares, Milagros Rocha
BACKGROUND: The C3 complement component (C3c) is increasingly recognized as a cardiometabolic risk factor, but how it is affected after weight loss through gastric bypass is a question yet to be answered. METHODS: A total of 66 obese patients underwent laparoscopic gastric bypass. Anthropometric parameters, total cholesterol (TC), triglycerides, high-density lipoprotein cholesterol (HDLc), low-density lipoprotein cholesterol (LDLc), glucose, insulin, HOMA-IR, liver enzymes, high-sensitivity C-reactive protein (hsCRP), and C3c levels were evaluated at baseline and at 1 and 5 years post-surgery...
May 3, 2016: Obesity Surgery
Raluca Pais, Philippe Giral, Jean-François Khan, David Rosenbaum, Chantal Housset, Thierry Poynard, Vlad Ratziu
BACKGROUND & AIMS: Whether steatosis is incidentally or causally associated with carotid atherosclerosis is debated, and long-term follow-up data are missing. This study aims to examine the impact of steatosis on the presence and progression of carotid intima-media thickness (C-IMT) and carotid plaques (CP) in a large cohort with longitudinal follow-up. METHODS: A retrospective single-center study between 1995 and 2012. Transversal cohort: patients with ⩾2 cardiovascular risk factors without previous cardiovascular events...
July 2016: Journal of Hepatology
Amar Nagesh Kumar, Jupalle Nagaiah Naidu, Uppala Satyanarayana, Krishnan Ramalingam, Medabalmi Anitha
BACKGROUND: Polycystic ovary syndrome (PCOS) is one of the most common endocrinological disorders among women of reproductive age and the leading cause of female infertility. This study intends to evaluate the lipid profile, hormonal levels [free T3 (fT3), free T4 (fT4), thyroid stimulating hormone (TSH), insulin, luteinizing hormone (LH), follicle stimulating hormone (FSH), and prolactin] in PCOS women from Nellore and its surrounding districts of Andhra Pradesh, India. MATERIALS AND METHODS: This cross-sectional study included 80 newly diagnosed PCOS women and an equal number of age and body mass index (BMI) matched healthy controls...
April 2016: International Journal of Fertility & Sterility
Daiana Ibarretxe, Josefa Girona, Núria Amigó, Núria Plana, Raimón Ferré, Sandra Guaita, Roger Mallol, Mercedes Heras, Luis Masana
BACKGROUND: The role of circulating FABP5 on metabolic alterations is under active evaluation. On the other hand, FABP5 SNPs (rs454550 and rs79370435) seem to modulate its effect. OBJECTIVES: Our aim was to examine the role of circulating FABP5 levels and its main SNPs in atherogenic dyslipidemia (AD) assessed by 2D-Nuclear Magnetic Resonance (NMR) and related metabolic and inflammation markers. We hypothesized that circulating FABP5 may be a biomarker for metabolic risk...
March 2016: Journal of Clinical Lipidology
Vinicius Pacheco Garcia, Helena Naly Miguens Rocha, Allan Robson Kluser Sales, Natália Galito Rocha, Antonio Claudio Lucas da Nóbrega
BACKGROUND: Metabolic syndrome (MetS) is associated with a higher risk of all-cause mortality. High-sensitivity C-reactive protein (hsCRP) is a prototypic marker of inflammation usually increased in MetS. Women with MetS-related diseases present higher hsCRP levels than men with MetS-related diseases, suggesting sex differences in inflammatory markers. However, it is unclear whether serum hsCRP levels are already increased in men and/or women with MetS risk factors and without overt diseases or under pharmacological treatment...
March 2016: Arquivos Brasileiros de Cardiologia
Victor M Victor, Susana Rovira-Llopis, Celia Bañuls, Noelia Diaz-Morales, Arantxa Martinez de Marañon, Cesar Rios-Navarro, Angeles Alvarez, Marcelino Gomez, Milagros Rocha, Antonio Hernández-Mijares
Cardiovascular diseases and oxidative stress are related to polycystic ovary syndrome (PCOS) and insulin resistance (IR). We have evaluated the relationship between myeloperoxidase (MPO) and leukocyte activation in PCOS patients according to homeostatic model assessment of IR (HOMA-IR), and have explored a possible correlation between these factors and endocrine and inflammatory parameters. This was a prospective controlled study conducted in an academic medical center. The study population consisted of 101 PCOS subjects and 105 control subjects...
2016: PloS One
Juan C Aristizabal, Jacqueline Barona, Laura I Gonzalez-Zapata, Gloria C Deossa, Alejandro Estrada
BACKGROUND: About one-third of the people with abdominal obesity do not exhibit the metabolic syndrome (MetS). Fatty acids in plasma triglycerides (TGs) may help to explain part of this heterogeneity. This study compared TG fatty acid profile of adults with and without abdominal obesity and examined the associations of these fatty acids with MetS components. METHODS: Fifty-four abdominally obese subjects were matched by age and sex with 54 adults without abdominal obesity...
August 2016: Metabolic Syndrome and related Disorders
Süha Çetin, Mustafa Gökhan Vural, Hüseyin Gündüz, Ramazan Akdemir, Hikmet Fırat
BACKGROUND: Obstructive sleep apnea (OSA) is a common syndrome in patients with metabolic syndrome (MetS). Epicardial fat thickness (EFT), an indicator of visceral adiposity, is a novel parameter for studying patients with OSA. Our aim was to investigate the effects of continuous positive airway pressure therapy (CPAP) therapy on EFT. METHODS: A total of 162 subjects (68 women and 94 men) were included and divided into three groups: Group I: Apnea-hypopnea index (AHI) < 5 (n  = 45), Group II: AHI 5-15 (n  = 22), and Group III: AHI > 15 (n  = 95)...
March 2016: Wiener Klinische Wochenschrift
Hyo-Sang Hwang, Kwang-Pil Ko, Myeong Gun Kim, Sihun Kim, Jeonggeun Moon, Wook Jin Chung, Mi Seung Shin, Seung Hwan Han
BACKGROUND: Subjects with abnormal metabolic conditions had increased risk for cardiovascular disease. We investigated the role of abnormal metabolic conditions on arterial stiffness in healthy subjects with no drug treatment. METHODS: A total 601 subjects (age 48.7 ± 11.8 years, male 46.2 %, hypertension 19.1 %) were enrolled. Major cardiovascular risk factors, metabolic conditions and parameters (pre-diabetes, diabetes mellitus, metabolic syndrome, fasting blood sugar (FBS), glycated hemoglobin), lipid profiles, hsCRP, and brachial ankle pulse wave velocity (baPWV) were measured...
2016: Clinical Hypertension
Mohamed Abu-Farha, Jehad Abubaker, Irina Al-Khairi, Preethi Cherian, Fiona Noronha, Sina Kavalakatt, Abdelkrim Khadir, Kazem Behbehani, Monira Alarouj, Abdullah Bennakhi, Naser Elkum
BACKGROUND: ANGPTL8 also called betatrophin is a regulator of lipid metabolism through its interaction with ANGPTL3. It has also been suggested to play a role in insulin resistance and beta-cell proliferation. Based on its function, we hypothesized that ANGPTL8 will play a role in Metabolic Syndrome (MetS). To test this hypothesis we designed this study to measure ANGPTL8 level in subjects with MetS as well as its association with high sensitivity C-reactive protein (HsCRP) level in humans...
2016: Cardiovascular Diabetology
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