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hscrp and metabolic syndrome

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https://www.readbyqxmd.com/read/29615976/higher-prevalence-of-low-t3-syndrome-in-patients-with-chronic-fatigue-syndrome-a-case-control-study
#1
Begoña Ruiz-Núñez, Rabab Tarasse, Emar F Vogelaar, D A Janneke Dijck-Brouwer, Frits A J Muskiet
Chronic fatigue syndrome (CFS) is a heterogeneous disease with unknown cause(s). CFS symptoms resemble a hypothyroid state, possibly secondary to chronic (low-grade) (metabolic) inflammation. We studied 98 CFS patients (21-69 years, 21 males) and 99 age- and sex-matched controls (19-65 years, 23 males). We measured parameters of thyroid function, (metabolic) inflammation, gut wall integrity and nutrients influencing thyroid function and/or inflammation. Most remarkably, CFS patients exhibited similar thyrotropin, but lower free triiodothyronine (FT3) (difference of medians 0...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29590229/association-of-oxytocin-with-glucose-intolerance-and-inflammation-biomarkers-in-metabolic-syndrome-patients-with-and-without-prediabetes
#2
Amal Akour, Violet Kasabri, Nailya Bulatova, Suha Al Muhaissen, Randa Naffa, Hiba Fahmawi, Munther Momani, Ayman Zayed, Yasser Bustanji
OBJECTIVES: The aim of this study was to explore the differences in OXT levels in metabolic syndrome (MetS) subjects, newly diagnosed type 2 diabetes mellitus (T2D), and prediabetes subjects vs. MetS subjects without glucose intolerance (non-diabetic MetS). It was also intended to determine the relationship between plasma OXT levels and inflammatory markers in those subjects. METHODS: Along with 45 lean and normoglycemic controls, a total of 190 MetS subjects (61 men, 129 women) were enrolled...
2018: Review of Diabetic Studies: RDS
https://www.readbyqxmd.com/read/29587769/circulating-osteopontin-and-its-association-with-liver-fat-content-in-non-obese-women-with-polycystic-ovary-syndrome-a-case-control-study
#3
Yuying Wang, Wei Zhou, Chunhua Wu, Yi Zhang, Tzuchun Lin, Yun Sun, Wei Liu, Tao Tao
BACKGROUND: Osteopontin (OPN) plays an important role in inflammatory processes and insulin resistance. Polycystic ovary syndrome (PCOS) is a reproductive metabolic disease associated with insulin resistance and metabolic abnormalities, including high levels of liver fat content (LFC). The objective of this study was to explore whether circulating OPN independently contributes to elevated LFC in non-obese PCOS patients. METHODS: This study included 61 non-obese PCOS patients and 56 age-matched healthy women from Shanghai, China...
March 27, 2018: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/29533157/longitudinal-examination-of-links-between-risk-factors-for-the-metabolic-syndrome-and-both-age-and-fasting-glucose-levels-in-nondiabetic-subjects
#4
Harry G Preuss, Gilbert R Kaats, Nate Mrvichin, Debasis Bagchi, Anand Swaroop
BACKGROUND: Previous evaluations in nondiabetic subjects revealed statistically significant correlations between fasting blood glucose (FBG) levels used as an estimate of insulin resistance and many components constituting the metabolic syndrome. Similar significant correlations were not found employing chronological age as the independent variable in the same nondiabetic individuals. OBJECTIVE: The major purpose here was to replicate as well as corroborate the previous cross-sectional observations, emphasizing results obtained from data collected longitudinally...
May 2018: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/29501444/association-between-habitual-coffee-consumption-and-metabolic-syndrome-in-type-1-diabetes
#5
B Stutz, A J Ahola, V Harjutsalo, C Forsblom, P-H Groop
BACKGROUND AND AIMS: In the general population, habitual coffee consumption is inversely associated with the metabolic syndrome, a syndrome that is rather common also in patients with type 1 diabetes. However, whether coffee intake is beneficially related to the metabolic syndrome also in type 1 diabetes, is not known. We, therefore, studied the potential association between coffee consumption and the metabolic syndrome in a large population of individuals with type 1 diabetes. Furthermore, we investigated whether coffee consumption is associated with insulin resistance (estimated glucose disposal rate, eGDR), kidney function (estimated glomerular filtration rate, eGFR), and low-grade chronic inflammation (high-sensitivity C-reactive protein, hsCRP)...
May 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29480399/the-effect-of-resistant-dextrin-as-a-prebiotic-on-metabolic-parameters-and-androgen-level-in-women-with-polycystic-ovarian-syndrome-a-randomized-triple-blind-controlled-clinical-trial
#6
Sevda Gholizadeh Shamasbi, Parvin Dehgan, Sakineh Mohammad-Alizadeh Charandabi, Akbar Aliasgarzadeh, Mojgan Mirghafourvand
INTRODUCTION: Polycystic ovary syndrome (PCOS) is one of the most common abnormalities in women of reproductive age that can lead to a variety of metabolic and reproductive disorders. Studies reveal that a healthy diet is the most effective way for treating the risk factors associated with metabolic disorders and place greater emphasis on the consumption of prebiotic foods. The present study aims to determine the effect of resistant Dextrin on metabolic parameters, including lipid profile, fasting blood glucose (FBS) and high sensitivity C-reactive protein (hsCRP), and androgen levels, including serum levels of dehydroepiandrosterone sulfate (DHEA-S) and free testosterone, as the primary outcomes, and manifestations of PCOS including menstrual cycle irregularity and hirsutism, as the secondary outcomes...
February 26, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29478813/the-effect-of-increasing-tertiles-of-waist-circumference-on-cardio-metabolic-risk-adipokines-and-biomarkers-of-inflammation-and-oxidative-stress-in-nascent-metabolic-syndrome
#7
Ishwarlal Jialal, Ganesh Jialal, Sridevi Devaraj, Beverley Adams-Huet
AIMS: The effect of waist circumference (WC) on cardio-metabolic features and biomarkers of oxidative stress and inflammation and adipose tissue dysregulation is poorly defined in Metabolic Syndrome (MetS). Hence the aim of this study was to examine the effect of increasing tertiles of WC on the cardio metabolic risk profile, pro-oxidant state, pro-inflammatory state and adipose tissue dysregulation in nascent MetS patients (n = 59) without diabetes or CVD. METHODS AND RESULTS: None of the main cardio-metabolic features including blood pressure, blood glucose, HDL-cholesterol, triglycerides, HOMA-IR, and free fatty acids increased with increasing WC tertiles except for hsCRP...
April 2018: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29421825/insulin-leptin-axis-cardiometabolic-risk-and-oxidative-stress-in-elderly-with-metabolic-syndrome
#8
Daniela Gradinaru, Husseina Khaddour, Denisa Margina, Anca Ungurianu, Claudia Borsa, Cristina Ionescu, Gabriel-Ioan Prada, Joshua Usher, Yahya Elshimali
Insulin and leptin have an overlapping anorexigenic action as well as opposite effects on glucose and lipid metabolism. The study focuses on the biochemical and clinical relevance of new indices of insulin-leptin axis utilized in the study of the relationships between leptinemia, insulin sensitivity and oxidative stress, in elderly subjects with metabolic syndrome. We conducted clinical studies on elderly people with metabolic syndrome versus control subjects by creating new insulin-adipogenic indices, namely Insulin-to-Leptin Ratio (ILR) and Insulin-Adipogenic Resistance index (IAR-index)...
February 8, 2018: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/29397035/psoriasis-and-cardiovascular-disease-risk-factors-the-hunt-study-norway
#9
I Snekvik, T I L Nilsen, P R Romundstad, M Saunes
BACKGROUND: Studies have examined the associations between psoriasis and cardiovascular diseases and their risk factors, but the results are conflicting, especially in the general population. OBJECTIVES: To investigate the association of psoriasis, and in particular psoriasis severity, with objectively measured cardiovascular disease risk factors and cardiovascular morbidity in a large population-based cross-sectional study. METHODS: We linked data on 50 245 persons in the HUNT3 Study, Norway, with information from the National Prescription Database to obtain information on use of psoriasis medication...
May 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29285778/in-women-with-pcos-waist-circumference-is-a-better-surrogate-of-glucose-and-lipid-metabolism-than-disease-status-per-se
#10
Agnieszka Pazderska, Tommy Kyaw Tun, Niamh Phelan, Anne McGowan, Mark Sherlock, LucyAnn Behan, Gerard Boran, James Gibney
OBJECTIVE: Cardiometabolic abnormalities are recognized in polycystic ovary syndrome (PCOS). However, over-emphasis on PCOS as a risk factor potentially results in over-investigation and treatment of some women with and under-recognition of cardiometabolic risk in obese women without PCOS. Our objective was to explore the association between waist circumference (WC) and indices of glucose and lipid metabolism in women with and without PCOS. DESIGN, PATIENTS AND MEASUREMENTS: (i) An exploratory cross-sectional study investigating association of potential cardiometabolic risk markers (PCOS status, anthropometric measures, hsCRP, HOMA-IR, SHBG, testosterone) with indices of glucose (frequently sampled intravenous glucose tolerance test) and lipid metabolism (postprandial studies and lipoprotein particle size) in 61 women with (n = 29) and without (n = 32) PCOS; (ii) a cross-sectional study in 103 PCOS women and 102 BMI-matched controls to explore if between-group differences in indices of lipid and glucose metabolism persist after adjusting for WC...
April 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29154418/measuring-non-polyaminated-lipocalin-2-for-cardiometabolic-risk-assessment
#11
Kangmin Yang, Han-Bing Deng, Andy W C Man, Erfei Song, Jialiang Zhang, Cuiting Luo, Bernard M Y Cheung, Kwok-Yung Yuen, Pia Søndergaard Jensen, Akhmadjon Irmukhamedov, Atlanta G I M Elie, Paul M Vanhoutte, Aimin Xu, Jo G R De Mey, Yu Wang
AIMS: Lipocalin-2 is a pro-inflammatory molecule characterized by a highly diversified pattern of expression and structure-functional relationships. In vivo, this molecule exists as multiple variants due to post-translational modifications and/or protein-protein interactions. Lipocalin-2 is modified by polyamination, which enhances the clearance of this protein from the circulation and prevents its excessive accumulation in tissues. On the other hand, animal studies suggest that non-polyaminated lipocalin-2 (npLcn2) plays a causal role in the pathogenesis of obesity-associated medical complications...
November 2017: ESC Heart Failure
https://www.readbyqxmd.com/read/29117621/gender-differences-in-cardiometabolic-risk-factors-in-metabolically-healthy-normal-weight-adults-with-central-obesity
#12
Katarína Šebeková, Melinda Csongová, Radana Gurecká, Zora Krivošíková, Jozef Šebek
We investigated whether metabolically healthy normal weight adults with central obesity display worse cardiometabolic profile compared with their centrally lean counterparts. This retrospective, cross-sectional study, comprised 1 135 subjects (64% females) aged 18-to-81 years, presenting ≤2 components of metabolic syndrome. They were classified as centrally lean (waist-to-height ratio (WHtR)<0.5 and waist circumference<80 cm in females and<94 cm in males) or presenting central obesity (WHtR ≥0...
November 8, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/29018156/the-effect-of-atorvastatin-on-pancreatic-beta-cell-requirement-in-women-with-polycystic-ovary-syndrome
#13
Thozhukat Sathyapalan, Anne-Marie Coady, Eric S Kilpatrick, Stephen L Atkin
BACKGROUND: There is an increased risk of developing T2DM in women with polycystic ovary syndrome (PCOS), and there is evidence that statins improve metabolic parameters in these patients. However, there are some data to show that statins increase the risk of incipient diabetes. MATERIALS AND METHODS: We have previously shown that 12 weeks of atorvastatin improves insulin resistance when measured using HOMA-IR. This post hoc analysis was designed to look at the effect of atorvastatin on pancreatic β cell function using HOMA-β in the same study...
November 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28977161/the-relationship-between-circulating-irisin-retinol-binding-protein-4-adiponectin-and-inflammatory-mediators-in-patients-with-metabolic-syndrome
#14
Omur Tabak, Gonul Simsek, Fusun Erdenen, Volkan Sozer, Tuna Hasoglu, Remise Gelisgen, Esma Altunoglu, Cuneyt Muderrisoglu, Abdulhalim Senyigit, Hafize Uzun
OBJECTIVE: We wanted to investigate whether there is a relationship between circulating irisin, retinol binding protein-4 (RBP-4), adiponectin and proinflammatory mediators implicated in the development of insulin resistance (IR) in metabolic syndrome (MetS). SUBJECTS AND METHODS: In 180 individuals, including controls and patients with MetS, we measured fasting plasma insulin, high sensitivity C-reactive protein (hsCRP), pentraxin-3 (PTX-3), interleukin-33 (IL-33), irisin, RBP-4, and adiponectin using ELISA kits...
December 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28914081/c-reactive-protein-is-associated-with-prevalence-of-the-metabolic-syndrome-hypertension-and-diabetes-mellitus-in-us-adults
#15
Mohsen Mazidi, Peter P Toth, Maciej Banach
The prevalence of metabolic syndrome (MetS) has increased globally and is associated with an increased risk of cardiovascular diseases that may be related to its association with inflammation. We have assessed whether the prevalence of the MetS correlates with a serum high-sensitivity C-reactive protein (hsCRP) concentration in a population-based sample of US men and women. Participants were selected from the US National Health and Nutrition Examination Survey from 2005 to 2010. Of the 17 689 participants analyzed, 8607 (48...
January 1, 2017: Angiology
https://www.readbyqxmd.com/read/28702888/cushing-s-syndrome-a-model-for-sarcopenic-obesity
#16
Michael Drey, Christina M Berr, Martin Reincke, Julia Fazel, Jochen Seissler, Jochen Schopohl, Martin Bidlingmaier, Stefanie Zopp, Nicole Reisch, Felix Beuschlein, Andrea Osswald, Ralf Schmidmaier
PURPOSE: Obesity and its metabolic impairments are discussed as major risk factors for sarcopenia leading to sarcopenic obesity. Cushing's syndrome is known to be associated with obesity and muscle atrophy. We compared Cushing's syndrome with matched obese controls regarding body composition, physical performance, and biochemical markers to test the hypothesis that Cushing's syndrome could be a model for sarcopenic obesity. METHODS: By propensity score matching, 47 controls were selected by body mass index and gender as obese controls...
September 2017: Endocrine
https://www.readbyqxmd.com/read/28637418/anti-inflammatory-effect-of-crocus-sativus-on-serum-cytokine-levels-in-subjects-with-metabolic-syndrome-a-randomized-double-blind-placebo-controlled-trial
#17
Tayebe Kermani, Maedeh Zebarjadi, Hassan Mehrad-Majd, Seyed-Reza Mirhafez, Maryam Shemshian, Faezeh Ghasemi, Elham Mohammadzadeh, Seyed Hadi Mousavi, Abdolreza Norouzy, Toktam Moghiman, Akram Sadeghi, Gordon Ferns, Amir Avan, Elaheh Mahdipour, Majid Ghayour-Mobarhan
BACKGROUND/AIMS: A growing body of evidence supports an important role of inflammatory cytokines in the development and progression of the Metabolic Syndrome (MetS), which explains, at least in part, its relationship with an increased cardiovascular-risk. Several studies have reported the therapeutic-impact of crocus-sativus in a preclinical/clinical setting. Here we have explored the effects of crocus-sativus, on the serum concentrations of twelve serum cytokines in subjects with MetS in a randomized control trial...
2017: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/28598285/effect-of-non-surgical-periodontal-therapy-along-with-myo-inositol-on-high-sensitivity-c-reactive-protein-and-insulin-resistance-in-women-with-polycystic-ovary-syndrome-and-chronic-periodontitis-a-randomized-controlled-trial
#18
Deepti, Shikha Tewari, Satish Chander Narula, Savita Rani Singhal, Rajinder Kumar Sharma
BACKGROUND: The purpose of this study is to evaluate the effect of non-surgical periodontal therapy and medical treatment on the level of a serologic marker of inflammation (high-sensitivity C-reactive protein [hsCRP]) and insulin resistance (homeostatic model assessment [HOMA]) in women with polycystic ovary syndrome (PCOS) and chronic periodontitis (CP). METHODS: Women with PCOS and CP (n = 60) were randomly divided into two groups. The test group was treated with scaling and root planing (SRP) and myo-inositol (MI)...
October 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28539823/association-between-sarcopenia-and-hearing-thresholds-in-postmenopausal-women
#19
Seok Hui Kang, Da Jung Jung, Kyu Hyang Cho, Jong Won Park, Kyu-Yup Lee, Jun Young Do
Background: Given the association between metabolic disturbance and sarcopenia, sarcopenia may be intrinsically associated with the prevalence of HL. However, few studies describe the association between sarcopenia and HL. The aim of this study was to evaluate the clinical association between sarcopenia and HL in postmenopausal Korean women. Patients and Methods: A total of 4,038 women were ultimately included in this study. All participants were postmenopausal. Participants were divided into two groups based on criteria from the Foundation for the National Institute of Health Sarcopenia Project: a normal group (sarcopenia index ≥ 0...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/28493240/does-vitamin-d-status-correlate-with-cardiometabolic-risk-factors-in-adults-with-growth-hormone-deficiency
#20
Ivayla Uzunova, Georgi Kirilov, Sabina Zacharieva, Naydenka Zlatareva, Krasimir Kalinov
Apart from being individually associated with cardiometabolic health, 25(OH)D and IGF-1 interplay with a positive correlation between them, which raises questions about the role of vitamin D for the adverse cardiovascular (CV) risk profile in hyposomatotropism. Thus, we aimed to investigate vitamin D status in GH deficiency (GHD) and the association between 25(OH)D and metabolic syndrome (MetS), its components, and other surrogate markers of CV risk. A total of 129 GHD adults (childhood-onset GHD, 41.9%) underwent blood testing (glucose, insulin, lipid profile, uric acid); blood pressure, anthropometric and bioelectrical-impedance measurements...
July 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
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