Sébastien Thériault, Zhonglin Li, Erik Abner, Jian'an Luan, Hasanga D Manikpurage, Ursula Houessou, Pardis Zamani, Mewen Briend, Dominique K Boudreau, Nathalie Gaudreault, Lily Frenette, Déborah Argaud, Manel Dahmene, François Dagenais, Marie-Annick Clavel, Philippe Pibarot, Benoit J Arsenault, S Matthijs Boekholdt, Nicholas J Wareham, Tõnu Esko, Patrick Mathieu, Yohan Bossé
There is currently no medical therapy to prevent calcific aortic valve stenosis (CAVS). Multi-omics approaches could lead to the identification of novel molecular targets. Here, we perform a genome-wide association study (GWAS) meta-analysis including 14,819 cases among 941,863 participants of European ancestry. We report 32 genomic loci, among which 20 are novel. RNA sequencing of 500 human aortic valves highlights an enrichment in expression regulation at these loci and prioritizes candidate causal genes...
March 18, 2024: Nature Communications