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https://www.readbyqxmd.com/read/27904945/-sarcoidosis-and-uveitis-an-update
#1
REVIEW
J G Garweg
Ocular involvement in sarcoidosis is present in up to one third of patients and is frequently manifested before the underlying systemic disease has been diagnosed. With a view to the therapeutic consequences an early diagnosis of the underlying disease is advantageous. In cases of visual loss early diagnostic measures include invasive procedures, such as ultrasound-guided bronchoalveolar lavage and transbronchial biopsy, if nodular conjunctival or cutaneous manifestations which would confirm the diagnosis are not present...
November 30, 2016: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/27904701/sirt6-suppresses-mitochondrial-defects-and-cell-death-via-the-nf-%C3%AE%C2%BAb-pathway-in-myocardial-hypoxia-reoxygenation-induced-injury
#2
Ming-Yue Cheng, You-Wei Cheng, Jun Yan, Xiao-Qin Hu, Hui Zhang, Zhi-Rong Wang, Qin Yin, Wei Cheng
The present study explored changes of the SIRT6/NF-κB pathway in myocardial hypoxia/reoxygenation induced injury and the effects on mitochondrial damage and myocardial damage by regulating SIRT6. SIRT6 expression decreased and NF-κB expression increased in H9c2 cells during hypoxic injury. Cell death and mitochondrial defects paralleled mPTP opening, and a decrease in ΔΨm occurred in hypoxic myocytes compared with normoxic control cells in annexin V and propidium iodide staining and TUNEL results. These effects were suppressed in cells overexpressing SIRT6, but reemerged in cells expressing the SIRT6 mutant...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27900315/effectiveness-and-efficiency-of-improving-hiv-service-provision-for-key-populations-in-nicaragua
#3
Edward Ivor Broughton, Oscar Nunez, Rafael Arana, Alexey Oviedo
OBJECTIVE: HIV in Nicaragua is concentrated among key populations (KPs) - men who have sex with men, female sex workers, and female transgender - in whom prevalence is 600-4,000 times higher than the general population. The United States Agency for International Development PrevenSida project is aimed at increasing healthy behavior among KPs and people with HIV and improving testing, counseling, and continuity of prevention and treatment by building capacity and improving performance of non-governmental organizations (NGOs) providing services to KPs...
2016: Frontiers in Public Health
https://www.readbyqxmd.com/read/27893864/cost-effectiveness-of-the-one4all-hiv-linkage-intervention-in-guangxi-zhuang-autonomous-region-china
#4
Xiao Zang, Houlin Tang, Jeong Eun Min, Diane Gu, Julio S G Montaner, Zunyou Wu, Bohdan Nosyk
BACKGROUND: In Guangxi Zhuang Autonomous Region, China, an estimated 80% of newly-identified antiretroviral therapy (ART)-eligible patients are not engaged in ART. Delayed ART uptake ultimately translates into high rates of HIV morbidity, mortality, and transmission. To enhance HIV testing receipt and subsequent treatment uptake in Guangxi, the Chinese Center for Disease Control and Prevention (CDC) executed a cluster-randomized trial to assess the effectiveness and cost-effectiveness of a streamlined HIV testing algorithm (the One4All intervention) in 12 county-level hospitals...
2016: PloS One
https://www.readbyqxmd.com/read/27891496/interpositional-gap-arthroplasty-by-versatile-pedicled-temporalis-myofascial-flap-in-the-management-of-temporomandibular-joint-ankylosis-a-case-series-study
#5
Vikas Aneja, Rushik Raval, Anupam Bansal, Vinod Kumawat, Jasleen Kaur, Ahemer Arif Shaikh
Temporomandibular Joint (TMJ) ankylosis is a situation in which the mandibular condyle is fused to the glenoid fossa by bone or fibrous tissue. The management of TMJ ankylosis has a complicated chore and it is challenging for the maxillofacial surgeon because of technical hitches and high rate of re-ankylosis. Interpositional gap arthroplasty is one of the modalities for its management. A range of inter-positional materials have been used to avert recurrence after gap arthroplasty in TMJ ankylosis. The aim of this series was to evaluate the effectiveness of the temporomyofacial flap in the treatment of TMJ ankylosis as an interpositional gap arthroplasty...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27890400/country-specific-predictions-of-the-cost-effectiveness-of-malaria-vaccine-rts-s-as01-in-endemic-africa
#6
Katya Galactionova, Fabrizio Tediosi, Flavia Camponovo, Thomas A Smith, Peter W Gething, Melissa A Penny
BACKGROUND: RTS,S/AS01 is a safe and moderately efficacious vaccine considered for implementation in endemic Africa. Model predictions of impact and cost-effectiveness of this new intervention could aid in country adoption decisions. METHODS: The impact of RTS,S was assessed in 43 countries using an ensemble of models of Plasmodium falciparum epidemiology. Informed by the 32months follow-up data from the phase 3 trial, vaccine effectiveness was evaluated at country levels of malaria parasite prevalence, coverage of control interventions and immunization...
November 24, 2016: Vaccine
https://www.readbyqxmd.com/read/27887640/functional-and-regulatory-profiling-of-energy-metabolism-in-fission-yeast
#7
Michal Malecki, Danny A Bitton, Maria Rodríguez-López, Charalampos Rallis, Noelia Garcia Calavia, Graeme C Smith, Jürg Bähler
BACKGROUND: The control of energy metabolism is fundamental for cell growth and function and anomalies in it are implicated in complex diseases and ageing. Metabolism in yeast cells can be manipulated by supplying different carbon sources: yeast grown on glucose rapidly proliferates by fermentation, analogous to tumour cells growing by aerobic glycolysis, whereas on non-fermentable carbon sources metabolism shifts towards respiration. RESULTS: We screened deletion libraries of fission yeast to identify over 200 genes required for respiratory growth...
November 25, 2016: Genome Biology
https://www.readbyqxmd.com/read/27885096/promoting-fluoroscopic-personal-radiation-protection-equipment-unfamiliarity-facts-and-fears
#8
Stephen Balter
An incomplete understanding of risk can cause inappropriate fear. Personal protective equipment (PPE) offered for the prevention of brain cancer in interventional fluoroscopists (IR-PPE). Similar items are offered for cell-phone use (RF-PPE). Publications on fluoroscopy staff brain cancer and similar papers on cell-phone induced brain cancer were reviewed. An internet safety product search was performed, which resulted in many tens of thousands of hits. Vendor claims for either ionizing radiation or radio frequency products seldom addressed the magnitude of the risk...
November 24, 2016: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/27884709/seeing-beyond-2020-an-economic-evaluation-of-contemporary-and-emerging-strategies-for-elimination-of-trypanosoma-brucei-gambiense
#9
C Simone Sutherland, Christopher M Stone, Peter Steinmann, Marcel Tanner, Fabrizio Tediosi
BACKGROUND: Trypanosoma brucei (T b) gambiense is targeted to reach elimination as a public health problem by 2020 and full elimination by 2030. To achieve these goals, stakeholders need to consider strategies to accelerate elimination. Hence, we aimed to model several options related to current and emerging methods for case detection, treatment, and vector control across settings to assess cost-effectiveness and the probability of elimination. METHODS: Five intervention strategies were modelled over 30 years for low, moderate, and high transmission settings...
November 21, 2016: Lancet Global Health
https://www.readbyqxmd.com/read/27884704/enhanced-aggressiveness-of-bystander-cells-in-an-anti-tumor-photodynamic-therapy-model-role-of-nitric-oxide-produced-by-targeted-cells
#10
Jerzy Bazak, Jonathan M Fahey, Katarzyna Wawak, Witold Korytowski, Albert W Girotti
The bystander effects of anti-cancer ionizing radiation have been widely studied, but far less is known about such effects in the case of non-ionizing photodynamic therapy (PDT). In the present study, we tested the hypothesis that photodynamically-stressed prostate cancer PC3 cells can elicit nitric oxide (NO)-mediated pro-growth/migration responses in non-stressed bystander cells. A novel approach was used whereby both cell populations existed on a culture dish, but made no physical contact with one other...
November 21, 2016: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/27881270/cost-effectiveness-of-screening-and-treatment-for-cervical-cancer-in-tanzania-implications-for-other-sub-saharan-african-countries
#11
Stephanie Nelson, Jungyoon Kim, Fernando A Wilson, Amr S Soliman, Twalib Ngoma, Crispin Kahesa, Julius Mwaiselage
OBJECTIVES: To compare the institutional cost per person of screening and treatment between two groups of patients-those screened and those not screened before treatment for cervical cancer at Ocean Road Cancer Institute (ORCI) in Dar es Salaam, Tanzania-and to perform a cost-effectiveness analysis of the ORCI cervical cancer screening program. METHODS: The study included 721 screened and 333 unscreened patients treated at ORCI for cervical cancer from 2002 to 2011...
September 2016: Value in Health Regional Issues
https://www.readbyqxmd.com/read/27880776/early-left-parietal-activity-elicited-by-direct-gaze-a-high-density-eeg-study
#12
Nicolas Burra, Dirk Kerzel, Nathalie George
Gaze is one of the most important cues for human communication and social interaction. In particular, gaze contact is the most primary form of social contact and it is thought to capture attention. A very early-differentiated brain response to direct versus averted gaze has been hypothesized. Here, we used high-density electroencephalography to test this hypothesis. Topographical analysis allowed us to uncover a very early topographic modulation (40-80 ms) of event-related responses to faces with direct as compared to averted gaze...
2016: PloS One
https://www.readbyqxmd.com/read/27879181/-integral-obstetrics-impeded-by-history-midwives-and-gynaecologists-through-the-ages
#13
N van der Lee, F Scheele
There is a long and complicated history concerning the interprofessional collaboration between midwives and gynaecologists, which is still evident in current practice. Yet, in the analysis of collaborative problems, history and its lessons are often overlooked. Consequently, less effective solutions to problems may be found, because the root cause of a problem is not addressed. In this historical perspective we show how policies of the respective professions have often focused on self-preservation and competition, rather than on effective collaboration...
2016: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/27878980/cost-effectiveness-of-mass-dog-vaccination-campaigns-against-rabies-in-flores-island-indonesia
#14
E Wera, M C M Mourits, M M Siko, H Hogeveen
A dynamic deterministic simulation model was developed to determine the cost-effectiveness of different mass dog vaccination strategies against rabies in a dog population representative of a typical village on Flores Island. Cost-effectiveness was measured as public cost per averted dog-rabies case. Simulations started with the introduction of one infectious dog into a susceptible dog population of 399 dogs and subsequently ran for a period of 10 years. The base scenario represented a situation without any control intervention...
November 23, 2016: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/27875082/effects-of-trazodone-on-behavioral-signs-of-stress-in-hospitalized-dogs
#15
Shana E Gilbert-Gregory, Jason W Stull, Mary Rose Rice, Meghan E Herron
OBJECTIVE To determine the effects of trazodone treatment on behavioral signs of stress in hospitalized dogs. DESIGN Prospective observational study. ANIMALS 120 client-owned dogs. PROCEDURES Hospitalized dogs administered trazodone (n = 60) were observed for stress-related signs or behaviors ≤ 45 minutes after the drug was administered (time 1) and approximately 90 minutes later (time 2). Dogs that did not receive trazodone (n = 60) were selected to serve as controls for environmental stimuli that could affect behavior and were observed at the same times...
December 1, 2016: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/27873083/the-cost-and-threshold-analysis-of-retention-in-care-ric-a-multi-site-national-hiv-care-program
#16
Catherine Maulsby, Kriti M Jain, Brian W Weir, Blessing Enobun, Maura Riordan, Vignetta E Charles, David R Holtgrave
Persons diagnosed with HIV but not retained in HIV medical care accounted for the majority of HIV transmissions in 2009 in the United States (US). There is an urgent need to implement and disseminate HIV retention in care programs; however little is known about the costs associated with implementing retention in care programs. We assessed the costs and cost-saving thresholds for seven Retention in Care (RiC) programs implemented in the US using standard methods recommended by the US Panel on Cost-effectiveness in Health and Medicine...
November 21, 2016: AIDS and Behavior
https://www.readbyqxmd.com/read/27872612/systems-biomedicine-of-rabies-delineates-the-affected-signaling-pathways
#17
Sadegh Azimzadeh Jamalkandi, Sayed-Hamidreza Mozhgani, Hamid Gholami Pourbadie, Mehdi Mirzaie, Farshid Noorbakhsh, Behrouz Vaziri, Alireza Gholami, Naser Ansari-Pour, Mohieddin Jafari
The prototypical neurotropic virus, rabies, is a member of the Rhabdoviridae family that causes lethal encephalomyelitis. Although there have been a plethora of studies investigating the etiological mechanism of the rabies virus and many precautionary methods have been implemented to avert the disease outbreak over the last century, the disease has surprisingly no definite remedy at its late stages. The psychological symptoms and the underlying etiology, as well as the rare survival rate from rabies encephalitis, has still remained a mystery...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27865653/evaluation-of-school-based-dental-sealant-programs-an-updated-community-guide-systematic-economic-review
#18
REVIEW
Susan O Griffin, Shillpa Naavaal, Christina Scherrer, Mona Patel, Sajal Chattopadhyay
CONTEXT: A recently updated Community Guide systematic review of the effectiveness of school sealant programs (SSPs) still found strong evidence that SSPs reduced dental caries among schoolchildren. This follow-up systematic review updates SSP cost and benefit information from the original 2002 review. EVIDENCE ACQUISITION: Using Community Guide economic review methods, the authors searched the literature from January 2000 to November 20, 2014. The final body of evidence included 14 studies-ten from the current search and four with cost information from the 2002 review...
November 16, 2016: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/27861924/intratympanic-dexamethasone-in-sudden-sensorineural-hearing-loss-a-systematic-review-and-meta-analysis
#19
REVIEW
Nagi G El Sabbagh, Maida J Sewitch, Aren Bezdjian, Sam J Daniel
OBJECTIVE: Systemic dexamethasone has demonstrated conclusive benefits in reversing sudden sensorineural hearing loss (SSNHL) despite considerable number of potential side effects. In contrast, the intratympanic route of steroid administration averts several possible complications. This study aims to examine the literature to delineate the efficacy and side effect of intratympanic dexamethasone (ITD) injection for the treatment of SSNHL. DATA SOURCE: Cochrane, Embase, and MEDLINE electronic databases from January 1950 to August 2014, with an update performed on November 10, 2014...
November 15, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27860281/counting-up-the-risks-how-common-are-risk-factors-for-morbidity-and-mortality-in-young-people-with-psychosis
#20
Lisa Anne Hahn, Andrew Mackinnon, Debra L Foley, Vera A Morgan, Anna Waterreus, Gerald F Watts, David J Castle, Dennis Liu, Cherrie A Galletly
BACKGROUND: This study examined the prevalence of risk factors for cardiovascular (CV)-related morbidity and mortality in young people with psychosis aged 18 to 24 years. METHODS: The study included 132 people aged 18 to 24 years who participated in the 2010 second Australian national survey of people living with psychosis. The 2009 World Health Organisation (WHO) Global Health Risks report was used as a framework to determine which specific risk factors were present in each in these young people...
November 17, 2016: Early Intervention in Psychiatry
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