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https://www.readbyqxmd.com/read/28817604/therapeutic-flexible-airway-endoscopy-of-small-children-in-a-tertiary-referral-center-11-years-experience
#1
Wen-Jue Soong, Pei-Chen Tsao, Yu-Sheng Lee, Chia-Feng Yang
OBJECTIVES: Use of therapeutic flexible airway endoscopy (TFAE) is very limited in pediatrics. We report our clinical experiences and long term outcomes of TFAE in small children from a single tertiary referral center. METHODS: This is a retrospective cohort study. Small children with their body weight no more than 5.0 kg who had received TFAE between 2005 and 2015 were enrolled. Demographic information and outcomes were reviewed and analyzed from medical charts and TFAE videos...
2017: PloS One
https://www.readbyqxmd.com/read/28816642/proteomic-analysis-of-the-human-olfactory-bulb
#2
Manjunath Dammalli, Gourav Dey, Anil K Madugundu, Manish Kumar, Benvil Rodrigues, Harsha Gowda, Bychapur Gowrishankar Siddaiah, Anita Mahadevan, Susarla Krishna Shankar, Thottethodi Subrahmanya Keshava Prasad
The importance of olfaction to human health and disease is often underappreciated. Olfactory dysfunction has been reported in association with a host of common complex diseases, including neurological diseases such as Alzheimer's disease and Parkinson's disease. For health, olfaction or the sense of smell is also important for most mammals, for optimal engagement with their environment. Indeed, animals have developed sophisticated olfactory systems to detect and interpret the rich information presented to them to assist in day-to-day activities such as locating food sources, differentiating food from poisons, identifying mates, promoting reproduction, avoiding predators, and averting death...
August 2017: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/28813636/using-systems-science-to-inform-population-health-strategies-in-local-health-departments-a-case-study-in-san-antonio-texas
#3
Yan Li, Norma A Padrón, Anil T Mangla, Pamela G Russo, Thomas Schlenker, José A Pagán
OBJECTIVES: Because of state and federal health care reform, local health departments play an increasingly prominent role leading and coordinating disease prevention programs in the United States. This case study shows how a local health department working in chronic disease prevention and management can use systems science and evidence-based decision making to inform program selection, implementation, and assessment; enhance engagement with local health systems and organizations; and possibly optimize health care delivery and population health...
January 1, 2017: Public Health Reports
https://www.readbyqxmd.com/read/28808319/ip-10-levels-as-an-accurate-screening-tool-to-detect-acute-hiv-infection-in-resource-limited-settings
#4
Lucía Pastor, Aina Casellas, Jorge Carrillo, Sergi Alonso, Erica Parker, Laura Fuente-Soro, Chenjerai Jairoce, Inacio Mandomando, Julià Blanco, Denise Naniche
Acute HIV infection (AHI) is the period prior to seroconversion characterized by high viral replication, hyper-transmission potential and commonly, non-specific febrile illness. AHI detection requires HIV-RNA viral load (VL) determination, which has very limited access in low-income countries due to restrictive costs and implementation constraints. We sought to identify a biomarker that could enable AHI diagnosis in scarce-resource settings, and to evaluate the feasibility of its implementation. HIV-seronegative adults presenting at the Manhiça District Hospital, Mozambique, with reported-fever were tested for VL...
August 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28807000/necrotizing-streptococcal-myositis-of-the-upper-extremity-a-case-report
#5
Johannes C Reichert, Götz Habild, Paul Simon, Ulrich Nöth, Jan B Krümpelmann
BACKGROUND: Necrotizing myositis is a rare but life-threatening soft-tissue infection characterized by rapidly spreading inflammation and subsequent necrosis of the affected tissue. The myositis is often caused by toxin-producing, virulent bacteria such as group A β-hemolytic streptococcus and associated with severe systemic toxicity. It is rapidly fatal unless diagnosed promptly and treated aggressively. However, necrotizing myositis is often initially misdiagnosed as a more benign soft-tissue infection as such fulminant, invasive muscle infections are rare with no more than 30 cases reported over the last century...
August 15, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28806786/an-economic-evaluation-of-vector-control-in-the-age-of-a-dengue-vaccine
#6
Christopher Fitzpatrick, Alexander Haines, Mathieu Bangert, Andrew Farlow, Janet Hemingway, Raman Velayudhan
INTRODUCTION: Dengue is a rapidly emerging vector-borne Neglected Tropical Disease, with a 30-fold increase in the number of cases reported since 1960. The economic cost of the illness is measured in the billions of dollars annually. Environmental change and unplanned urbanization are conspiring to raise the health and economic cost even further beyond the reach of health systems and households. The health-sector response has depended in large part on control of the Aedes aegypti and Ae...
August 14, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28800428/socially-anxious-tendencies-affect-neural-processing-of-gaze-perception
#7
Yuki Tsuji, Sotaro Shimada
The gaze of others is known to be a particularly common cause of social anxiety. In the current study, we measured event-related potentials (ERPs) during gaze perception among people with or without high socially anxious tendencies (HSA). The experimental stimuli were grayscale images of the eye region of a face, showing direct or averted eye gaze (leftward gaze or rightward gaze) or closed eyes. We found that negative ERPs at a right occipito-temporal site (N170) and positive ERPs at the fronto-central region (P2) were evoked by eye gaze stimuli...
August 8, 2017: Brain and Cognition
https://www.readbyqxmd.com/read/28798738/zika-virus-an-emerging-worldwide-threat
#8
Irfan A Rather, Jameel B Lone, Vivek K Bajpai, Woon K Paek, Jeongheui Lim
ZIKA virus (ZIKV) poses a severe threat to the world. Recent outbreaks of ZIKV after 2007 along with its quick transmission have made this virus a matter of international concern. The virus shows symptoms that are similar to those caused in the wake of dengue virus (DENV) and other flaviviruses, which makes it difficult to discern the viral infection. Diagnosis is further complicated as the virus cross-reacts with antibodies of other viruses. Currently, molecular diagnosis of the virus is being performed by RT-PCR and IgM-captured enzyme-linked immunosorbent assay (MAC-ELISA)...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28798263/cost-effectiveness-of-a-smokeless-tobacco-control-mass-media-campaign-in-india
#9
Nandita Murukutla, Hongjin Yan, Shuo Wang, Nalin Singh Negi, Alexey Kotov, Sandra Mullin, Mark Goodchild
BACKGROUND: Tobacco control mass media campaigns are cost-effective in reducing tobacco consumption in high-income countries, but similar evidence from low-income countries is limited. An evaluation of a 2009 smokeless tobacco control mass media campaign in India provided an opportunity to test its cost-effectiveness. METHODS: Campaign evaluation data from a nationally representative household survey of 2898 smokeless tobacco users were compared with campaign costs in a standard cost-effectiveness methodology...
August 10, 2017: Tobacco Control
https://www.readbyqxmd.com/read/28797537/mortality-associated-with-less-intense-risk-factor-control-among-adults-with-diabetes-in-the-united-states
#10
Sharon H Saydah, Edward W Gregg, Henry S Kahn, Mohammed K Ali
AIMS: Determine the mortality experience among adults with diabetes in meeting and not meeting less intense control for glycated hemoglobin (HbA1c), blood pressure (BP), and cholesterol. METHODS: National Health and Nutrition Examination Survey 1999-2010 participants with self-report of diagnosed diabetes (N=3335), measured HbA1c, BP and non-HDL cholesterol were linked to the National Death Index through December 31, 2011. Proportional hazards models were used to estimate hazard ratios (HR) of meeting HbA1c<9% and BP<160/110, and non-HDL cholesterol<190mg/dL...
August 7, 2017: Primary Care Diabetes
https://www.readbyqxmd.com/read/28797417/implications-of-coronary-artery-calcium%C3%A2-testing-for-treatment-decisions-among-statin-candidates-according-to%C3%A2-the%C3%A2-acc-aha-cholesterol-management%C3%A2-guidelines-a-cost-effectiveness-analysis
#11
REVIEW
Jonathan C Hong, Ron Blankstein, Leslee J Shaw, William V Padula, Alejandro Arrieta, Jonathan A Fialkow, Roger S Blumenthal, Michael J Blaha, Harlan M Krumholz, Khurram Nasir
This review evaluates the cost-effectiveness of using coronary artery calcium (CAC) to guide long-term statin therapy compared with treating all patients eligible for statins according to 2013 American College of Cardiology/American Heart Association cholesterol management guidelines for atherosclerotic cardiovascular disease. The authors used a microsimulation model to compare costs and effectiveness from a societal perspective over a lifetime horizon. Both strategies resulted in similar costs and quality-adjusted life years (QALYs)...
August 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28794535/epidural-analgesia-information-card-averted-permanent-neurological-sequelae
#12
Sumitra G Bakshi, Gautham Rajan, Parmanand N Jain
No abstract text is available yet for this article.
July 2017: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/28793866/strategies-for-the-prevention-of-perinatal-hepatitis-b-transmission-in-a-marginalized-population-on-the-thailand-myanmar-border-a-cost-effectiveness-analysis
#13
Angela Devine, Rebecca Harvey, Aung Myat Min, Mary Ellen T Gilder, Moo Koh Paw, Joy Kang, Isabella Watts, Borimas Hanboonkunupakarn, François Nosten, Rose McGready
BACKGROUND: Data on the cost effectiveness of hepatitis B virus (HBV) screening and vaccination strategies for prevention of vertical transmission of HBV in resource limited settings is sparse. METHODS: A decision tree model of HBV prevention strategies utilised data from a cohort of 7071 pregnant women on the Thailand-Myanmar border using a provider perspective. All options included universal HBV vaccination for newborns in three strategies: (1) universal vaccination alone; (2) universal vaccination with screening of women during antenatal visits with rapid diagnostic test (RDT) plus HBV immune globulin (HBIG) administration to newborns of HBV surface antigen positive women; and (3) universal vaccination with screening of women during antenatal visits plus HBIG administration to newborns of women testing HBV e antigen positive by confirmatory test...
August 9, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28792876/nad-deficiency-congenital-malformations-and-niacin-supplementation
#14
Hongjun Shi, Annabelle Enriquez, Melissa Rapadas, Ella M M A Martin, Roni Wang, Julie Moreau, Chai K Lim, Justin O Szot, Eddie Ip, James N Hughes, Kotaro Sugimoto, David T Humphreys, Aideen M McInerney-Leo, Paul J Leo, Ghassan J Maghzal, Jake Halliday, Janine Smith, Alison Colley, Paul R Mark, Felicity Collins, David O Sillence, David S Winlaw, Joshua W K Ho, Gilles J Guillemin, Matthew A Brown, Kazu Kikuchi, Paul Q Thomas, Roland Stocker, Eleni Giannoulatou, Gavin Chapman, Emma L Duncan, Duncan B Sparrow, Sally L Dunwoodie
BACKGROUND: Congenital malformations can be manifested as combinations of phenotypes that co-occur more often than expected by chance. In many such cases, it has proved difficult to identify a genetic cause. We sought the genetic cause of cardiac, vertebral, and renal defects, among others, in unrelated patients. METHODS: We used genomic sequencing to identify potentially pathogenic gene variants in families in which a person had multiple congenital malformations...
August 10, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28792611/modulation-of-the-eyeblink-and-cardiac-startle-reflexes-by-genuine-eye-contact
#15
Tingji Chen, Mikko J Peltola, Richard Dunn, Sanna M Pajunen, Jari K Hietanen
Is another person's direct gaze an inherently positive or negative stimulus? The present study employed the startle reflex methodology to investigate individuals' automatic reactions to another person's direct and averted gaze. In the study, participants' eyeblink startle and cardiac reflexes elicited by a high-intensity acoustic noise stimulus were measured in the context of viewing a live model's direct and downward gaze. Both the eyeblink electromyographic and electrocardiographic data revealed that the startle reflex was modulated by gaze direction...
August 9, 2017: Psychophysiology
https://www.readbyqxmd.com/read/28791308/recovery-following-thyroxine-treatment-withdrawal-but-not-propylthiouracil-averts-in-vivo-and-ex-vivo-thyroxine-provoked-cardiac-complications-in-adult-fvb-n-mice
#16
Nancy S Saad, Steven J Repas, Kyle Floyd, Paul M L Janssen, Mohammad T Elnakish
Persistent cardiovascular pathology has been described in hyperthyroid patients even with effective antithyroid treatment. Here, we studied the effect of a well-known antithyroid drug, propylthiouracil (PTU; 20 mg/kg/day), on thyroxine (T4; 500 µg/kg/day)-induced increase in blood pressure (BP), cardiac hypertrophy, and altered responses of the contractile myocardium both in vivo and ex vivo after 2 weeks of treatment. Furthermore, the potential recovery through 2 weeks of T4 treatment discontinuation was also investigated...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28789613/risk-factors-of-metabolic-syndrome-among-hypertensive-patients-at-hawassa-university-comprehensive-specialized-hospital-southern-ethiopia
#17
Agete Tadewos, Tariku Egeno, Antenah Amsalu
BACKGROUND: Data regarding the prevalence of metabolic syndrome (MetS) among hypertensive patients in Ethiopia is very scarce, and the nature and the burden of MetS among these patients has not been well investigated. Therefore, the aim of this study was to assess the pattern and risk factors of MetS in hypertensive patients. METHODS: A cross-sectional study was conducted at Hawassa University comprehensive specialized hospital from September 2015 to June 2016. Data on socio-demographic, clinical and anthropometric characteristics were collected from 238 hypertensive participants using WHO stepwise technique...
August 8, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28780491/health-impact-modelling-of-different-travel-patterns-on-physical-activity-air-pollution-and-road-injuries-for-s%C3%A3-o-paulo-brazil
#18
Thiago Hérick de Sá, Marko Tainio, Anna Goodman, Phil Edwards, Andy Haines, Nelson Gouveia, Carlos Monteiro, James Woodcock
BACKGROUND: São Paulo city, Brazil, faces challenges caused by rapid urbanization. We illustrate how future travel patterns could lead to different health consequences in the city. METHODS: We evaluated the health impacts of different travel pattern scenarios for the São Paulo adult population by comparing the travel patterns of São Paulo in 2012 with counterfactual scenarios in which the city adopted travel patterns of i) those living in the city's expanded centre; ii) London (2012); iii) a highly motorized São Paulo (SP California); and iv) a visionary São Paulo (SP 2040), with high levels of walking and cycling and low levels of car and motorcycle use...
August 3, 2017: Environment International
https://www.readbyqxmd.com/read/28780240/doing-more-for-less-identifying-opportunities-to-expand-public-sector-access-to-safe-abortion-in-south-africa-through-budget-impact-analysis
#19
N Lince-Deroche, J Harries, D Constant, C Morroni, M Pleaner, T Fetters, D Grossman, K Blanchard, E Sinanovic
OBJECTIVE(S): To estimate the costs of public-sector abortion provision in South Africa and to explore the potential for expanding access at reduced cost by changing the mix of technologies used. STUDY DESIGN: We conducted a budget impact analysis using public sector abortion statistics and published cost data. We estimated the total costs to the public health service over ten years, starting in South Africa's financial year 2016/17, given four scenarios: 1) holding service provision constant, 2) expanding public sector provision, 3) changing the abortion technologies used (i...
August 3, 2017: Contraception
https://www.readbyqxmd.com/read/28777716/research-priorities-in-subspecialty-palliative-care-policy-initiatives
#20
Lynn F Reinke, Diane E Meier
Palliative care demonstrably improves quality of life for the seriously ill in a manner that averts preventable health crises and their associated costs. Because of these outcomes, palliative care is now broadening its reach beyond hospitals, and hospice care for those near death, to patients and their families living in the community with chronic multimorbidities that have uncertain or long expected survival. In this article, we address research needed to enable policies supportive of palliative care access and quality, including changes in regulatory, accreditation, financing, and training approaches in the purview of policy makers...
August 2017: Journal of Palliative Medicine
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