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Immune Colon Cancer

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https://www.readbyqxmd.com/read/29327939/blockade-of-the-complement-c5a-c5ar1-axis-impairs-lung-cancer-bone-metastasis-by-cxcl16-mediated-effects
#1
Daniel Ajona, Carolina Zandueta, Leticia Corrales, Haritz Moreno, María J Pajares, Sergio Ortiz-Espinosa, Elena Martínez-Terroba, Naiara Perurena, Fernando J de Miguel, Eloisa Jantus-Lewintre, Carlos Camps, Silvestre Vicent, Jackeline Agorreta, Luis M Montuenga, Ruben Pio, Fernando Lecanda
RATIONALE: C5aR1(CD88), a receptor for complement anaphylatoxin C5a, is a potent immune mediator. Its impact on malignant growth and dissemination of NSCLC cells is poorly understood. OBJECTIVES: To investigate the contribution of the C5a/C5aR1 axis to the malignant phenotype of NSCLC cells, particularly in skeletal colonization, a preferential lung metastasis site. METHODS: Association between C5aR1 expression and clinical outcome was assessed in silico and validated by immunohistochemistry...
January 12, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29322404/in-vivo-models-of-inflammatory-bowel-disease-and-colitis-associated-cancer
#2
Ka Yee Fung, Tracy Putoczki
A single layer of epithelial cells separates luminal antigens from the host immune system throughout the gastrointestinal tract. A breakdown in the integrity of the epithelial barrier can lead to chronic inflammation, which is associated with numerous complications including cancer. Here we describe three experimental protocols to chemically induce acute and chronic inflammatory bowel disease (IBD) symptoms and colitis-associated colorectal cancer (CRC) progression. These in vivo mouse models are based on the induction of damage to the colonic epithelium, resulting in an inflammatory and wound healing response...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29320521/cd8-t-cell-infiltration-in-breast-and-colon-cancer-a-histologic-and-statistical-analysis
#3
James Ziai, Houston N Gilbert, Oded Foreman, Jeffrey Eastham-Anderson, Felix Chu, Mahrukh Huseni, Jeong M Kim
The prevalence of cytotoxic tumor infiltrating lymphocytes (TILs) has demonstrated prognostic value in multiple tumor types. In particular, CD8 counts (in combination with CD3 and CD45RO) have been shown to be superior to traditional UICC staging in colon cancer patients and higher total CD8 counts have been associated with better survival in breast cancer patients. However, immune infiltrate heterogeneity can lead to potentially significant misrepresentations of marker prevalence in routine histologic sections...
2018: PloS One
https://www.readbyqxmd.com/read/29320431/galectin-targeted-therapy-in-oncology-current-knowledge-and-perspectives
#4
REVIEW
Kamil Wdowiak, Tomasz Francuz, Enrique Gallego-Colon, Natalia Ruiz-Agamez, Marcin Kubeczko, Iga Grochoła, Jerzy Wojnar
The incidence and mortality of cancer have increased over the past decades. Significant progress has been made in understanding the underpinnings of this disease and developing therapies. Despite this, cancer still remains a major therapeutic challenge. Current therapeutic research has targeted several aspects of the disease such as cancer development, growth, angiogenesis and metastases. Many molecular and cellular mechanisms remain unknown and current therapies have so far failed to meet their intended potential...
January 10, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29290782/hypothesis-induction-of-biomarkers-for-detection-of-colonic-neoplasms
#5
Michael Bordonaro, Darina Lazarova
The signing of the National Cancer Act of 1971 by President Nixon marked the beginning of our war on cancer. More than 45 years later, the war is still going steady, with the enemy being almost as strong as in 1971. Furthermore, the increasing rates of obesity not only among adults, but among children and adolescents, are the likely cause for the 30-year trend of colon cancer (CC) becoming a disease of the younger population in the U.S. These trends, however, have not spurred the development of novel screening approaches for CC...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29289834/differential-ratios-of-fish-corn-oil-ameliorated-the-colon-carcinoma-in-rat-by-altering-intestinal-intraepithelial-cd8-t-lymphocytes-dendritic-cells-population-and-modulating-the-intracellular-cytokines
#6
Renuka, Navneet Agnihotri, Archana Bhatnagar
Intraepithelial lymphocytes (IELs) impart a crucial role in maintaining intestinal homeostasis, yet their role in colon cancer pathogenesis remains unknown. Here, we posited that the modulation of intestinal immune response via dietary interventions might be an implacable strategy in restraining colon carcinoma. In the above context, we studied the effect of differential ratios of fish oil (FO) and corn oil (CO) on the gut immune response in experimentally induced colon cancer. Male Wistar rats were divided into six groups: Group I obtained purified diet while Groups II and III were fed on the diet supplemented with differential ratios of FO and CO i...
December 28, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29285324/focus-on-periodontal-disease-and-colorectal-carcinoma
#7
REVIEW
D Lauritano, L Sbordone, M Nardone, A Iapichino, L Scapoli, F Carinci
Diagnosis of focal disease, the theory that the human oral microbial (HOM) could affect the onset and development of systemic diseases, was very popular in the past, but the lack of scientific evidence has led to the abandonment of this idea. Interestingly, increasing evidence over the past 3 or so decades suggests that HOM can indeed serve as a reservoir for systemic dissemination of pathogenic bacteria and their toxins in distant body sites, favouring the developments of malignant tumours. Malignant tumours are complex communities of oncogenically transformed cells with aberrant genomes, associated non-neoplastic cells including immune and stromal cells, and sometimes HOM, including bacteria and viruses...
July 2017: Oral & Implantology
https://www.readbyqxmd.com/read/29285274/lipopolysaccharide-coated-cus-nanoparticles-promoted-anti-cancer-and-anti-metastatic-effect-by-immuno-photothermal-therapy
#8
Bian Jang, Li Xu, Madhappan S Moorthy, Wei Zhang, Ling Zeng, Mingyeong Kang, Minseok Kwak, Junghwan Oh, Jun-O Jin
To meet the ultimate goal of cancer therapy, which is treating not only the primary tumor but also preventing metastatic cancer, the concept of combining immunotherapy with photothermal therapy (PTT) is gaining great interest. Here, we studied the new material, lipopolysaccharide (LPS) coated copper sulfide nanoparticles (LPS-CuS), for the immuno-photothermal therapy. We evaluated the effect of LPS-CuS for induction of apoptosis of CT26 cells and activation of dendritic cells. Moreover, the LPS-CuS and laser irradiation was examined anti-metastasis effect by liver metastasis model mouse in vivo...
December 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/29285252/immunological-landscape-of-consensus-clusters-in-colorectal-cancer
#9
Pawel Karpinski, Joanna Rossowska, Maria Malgorzata Sasiadek
Recent, large-scale expression-based subtyping has advanced our understanding of the genomic landscape of colorectal cancer (CRC) and resulted in a consensus molecular classification that enables the categorization of most CRC tumors into one of four consensus molecular subtypes (CMS). Currently, major progress in characterization of immune landscape of tumor-associated microenvironment has been made especially with respect to microsatellite status of CRCs. While these studies profoundly improved the understanding of molecular and immunological profile of CRCs heterogeneity less is known about repertoire of the tumor infiltrating immune cells of each CMS...
December 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/29279482/immune-related-colitis-induced-by-the-long-term-use-of-nivolumab-in-a-patient-with-non-small-cell-lung-cancer
#10
Yuichiro Yasuda, Yoshiko Urata, Rie Tohnai, Shoichi Ito, Yoshitaka Kawa, Yuko Kono, Yoshihiro Hattori, Masahiro Tsuda, Toshiko Sakuma, Shunichi Negoro, Miyako Satouchi
We herein report a case of immune-related colitis induced by the long-term use of nivolumab. A 62-year-old Japanese man was treated with nivolumab at 3 mg/kg every 2 weeks for advanced lung adenocarcinoma. The patient was admitted to our hospital due to non-bloody watery diarrhea after the 70th dose of nivolumab. A biopsy specimen of the colon mucosa revealed evidence of colitis with cryptitis and crypt microabscesses. He was diagnosed with immune-related colitis and started on predonisolone 60 mg/day. Subsequently, his symptoms remarkably resolved...
December 27, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29276690/effects-of-intragastrically-administered-tepary-bean-lectins-on-digestive-and-immune-organs-preclinical-evaluation
#11
Julia María Alatorre-Cruz, Wendoline Pita-López, Rosa Guadalupe López-Reyes, Roberto Augusto Ferriz-Martínez, Ricardo Cervantes-Jiménez, María de Jesús Guerrero Carrillo, Paola Jazmín Aranda Vargas, Gabriela López-Herrera, Adriana Jheny Rodríguez-Méndez, Aarón Zamora-Arroyo, Héctor Gutiérrez-Sánchez, Tércia Reis de Souza, Alejandro Blanco-Labra, Teresa García-Gasca
Previous work showed that Tepary bean (Phaseolus acutifolius) lectins exhibit differential cytotoxic effects on cancer cell lines by apoptosis induction. In vivo studies using a Tepary bean lectin fraction (TBLF, 50 mg/kg of body weight) after colon cancer induction in rats showed that TBLF inhibited early precancerous lesions without systemic toxicity however, loss of body weight gain and activation of immune cells were observed. In order to know more about the possible adverse effects, we evaluated the administration of TBLF on digestive and immune organs...
2018: Toxicology Reports
https://www.readbyqxmd.com/read/29259036/loss-of-acid-ceramidase-in-myeloid-cells-suppresses-intestinal-neutrophil-recruitment
#12
Mel Pilar Espaillat, Ashley J Snider, Zhijuan Qiu, Breana Channer, Nicolas Coant, Edward H Schuchman, Richard R Kew, Brian S Sheridan, Yusuf A Hannun, Lina M Obeid
Bioactive sphingolipids are modulators of immune processes and their metabolism is often dysregulated in ulcerative colitis, a major category of inflammatory bowel disease (IBD). While multiple axes of sphingolipid metabolism have been investigated to delineate mechanisms regulating ulcerative colitis, the role of acid ceramidase (AC) in intestinal inflammation is yet to be characterized. Here we demonstrate that AC expression is elevated selectively in the inflammatory infiltrate in human and murine colitis...
December 19, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29245949/functional-profiling-of-microtumors-to-identify-cancer-associated-fibroblast-derived-drug-targets
#13
Shane R Horman, Jeremy To, John Lamb, Jocelyn H Zoll, Nicole Leonetti, Buu Tu, Rita Moran, Robbin Newlin, John R Walker, Anthony P Orth
Recent advances in chemotherapeutics highlight the importance of molecularly-targeted perturbagens. Although these therapies typically address dysregulated cancer cell proteins, there are increasing therapeutic modalities that take into consideration cancer cell-extrinsic factors. Targeting components of tumor stroma such as vascular or immune cells has been shown to represent an efficacious approach in cancer treatment. Cancer-associated fibroblasts (CAFs) exemplify an important stromal component that can be exploited in targeted therapeutics, though their employment in drug discovery campaigns has been relatively minimal due to technical logistics in assaying for CAF-tumor interactions...
November 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/29238349/the-roles-of-glycodelin-in-cancer-development-and-progression
#14
REVIEW
Juan Cui, Yanguo Liu, Xiuwen Wang
Glycodelin is a kind of glycoprotein expressed in secretory endometrium, pregnancy deciduas, and amniotic fluid originally, which is vital for the maintenance of normal human reproductive activities. Recent researches have reported that glycodelin is specifically expressed in various malignancies, including female-specific cancers such as endometrial cancer, ovarian cancer and breast cancer, and non-gender specific cancers including lung cancer, and colon cancer, and glycodelin expression correlates with the diagnosis and prognosis of cancer patients...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29234933/micrornas-and-metastasis-small-rnas-play-big-roles
#15
Jongchan Kim, Fan Yao, Zhenna Xiao, Yutong Sun, Li Ma
MicroRNAs (miRNAs) are small non-coding RNAs regulating post-transcriptional gene expression. They play important roles in many biological processes under physiological or pathological conditions, including development, metabolism, tumorigenesis, metastasis, and immune response. Over the past 15 years, significant insights have been gained into the roles of miRNAs in cancer. Depending on the cancer type, miRNAs can act as oncogenes, tumor suppressors, or metastasis regulators. In this review, we focus on the role of miRNAs as components of molecular networks regulating metastasis...
December 12, 2017: Cancer Metastasis Reviews
https://www.readbyqxmd.com/read/29230377/clinical-significance-of-circulating-immune-cells-in-left-and-right-sided-colon-cancer
#16
Jiabo Di, Meng Zhuang, Hong Yang, Beihai Jiang, Zaozao Wang, Xiangqian Su
Background: Left-sided and right-sided colon cancers (LCCs and RCCs, respectively) differ in their epidemiology, pathogenesis, genetic and epigenetic alterations, molecular pathways and prognosis. Notably, immune response gene expression profiles have been shown to differ between patients with LCC and patients with RCC. The immune system plays an important role in tumor immunosurveillance, and there is increasing evidence that peripheral blood immune cells have a profound influence on tumor prognosis...
2017: PeerJ
https://www.readbyqxmd.com/read/29225184/control-of-polarization-and-tumoricidal-activity-of-macrophages-by-multicellular-spheroid-formation
#17
Yutaro Tanaka, Makiya Nishikawa, Yuya Mizukami, Kosuke Kusamori, Yuka Ogino, Shunsuke Nishimura, Kazunori Shimizu, Satoshi Konishi, Yuki Takahashi, Yoshinobu Takakura
Immune cell-based therapy is a promising approach for cancer immunotherapy. Macrophages can be used for this purpose if their tumoricidal activity and viability are properly controlled. In the present study, we aimed to enhance these properties of macrophages by constructing uniformly sized multicellular spheroids. Mouse macrophage-like J774.1 cells were selected as model macrophages, and poly(N-isopropylacrylamide)-coated polydimethylsiloxane-based microwell plates with an approximate diameter of 750μm were used to prepare J774...
December 7, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29223485/preventive-effect-of-anti-vaca-egg-yolk-immunoglobulin-igy-on-helicobacter-pylori-infected-mice
#18
Kyung Sook Hong, Mi-Ran Ki, H M Arif Ullah, Eun-Joo Lee, Yong Deuk Kim, Myung-Jin Chung, Ahmed K Elfadl, Jin-Kyu Park, Kyu-Shik Jeong
BACKGROUND: Helicobacter pylori, a gram-negative bacterium, is the causative agent of gastric disorders and gastric cancer in the human stomach. Vacuolating cytotoxin A (VacA) is among the multi-effect protein toxins released by H. pylori that enables its persistence in the human stomach. METHODS: To evaluate the effect of anti-VacA egg yolk immunoglobulin (anti-VacA IgY) on H. pylori infection, a highly specific anti-VacA IgY was produced from egg yolks of hens immunized with a mixture of two purified recombinant VacAs...
December 6, 2017: Vaccine
https://www.readbyqxmd.com/read/29218075/il-32%C3%AE-a-recently-identified-anti-inflammatory-variant-of-il-32-and-its-preventive-role-in-various-disorders-and-tumor-suppressor-activity
#19
REVIEW
Muhammad Babar Khawar, Maryam Mukhtar, Muddasir Hassan Abbasi, Nadeem Sheikh
Interleukin-32 theta (IL-32θ) is newly identified isoform of IL-32 which plays a vital role in inflammatory responses. Like IL-32α and IL-32β, IL-32θ isoform acts as an intracellular inflammatory modulator. It results in reduction of IL-1β production by attenuating the expression of PU.1 and inhibition of monocytes differentiation into macrophages. IL-32θ hinders TNF-α expression by inhibiting p38 MAPK and inhibitor of κB (IκB) as well. It also reserved STAT3-ZEB1 pathway leading to the inhibition of epithelial-mesenchymal transition (EMT) and stemness...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/29212256/matrix-metalloproteinase-mmp9-maintains-epithelial-barrier-function-and-preserves-mucosal-lining-in-colitis-associated-cancer
#20
Adani Pujada, Lewins Walter, Aashka Patel, Tien Anh Bui, Zhan Zhang, Yuchen Zhang, Timothy Luke Denning, Pallavi Garg
In colitis associated cancer (CAC), chronic inflammation exposes the epithelial mucosal defensive lining to inflammatory mediators such as cytokines and anti-microbial peptides (AMPs) causing the dysbiosis of microbiota population and the dysregulation of immune response. Matrix Metalloproteinases (MMPs) are zinc dependent endopeptidases which mediate inflammation, tissue remodeling, and carcinogenesis. MMP9 is undetectable in healthy tissue, although highly upregulated during inflammation and cancer. We have previously shown that MMP9 plays a protective role in CAC opposite to its conventional role of acute inflammation and cancer mediator...
November 7, 2017: Oncotarget
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