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Large vessel vasculitis

Christina Duftner, Christian Dejaco, Alexandre Sepriano, Louise Falzon, Wolfgang Andreas Schmidt, Sofia Ramiro
Objectives: To perform a systematic literature review on imaging techniques for diagnosis, outcome prediction and disease monitoring in large vessel vasculitis (LVV) informing the European League Against Rheumatism recommendations for imaging in LVV. Methods: Systematic literature review (until 10 March 2017) of diagnostic and prognostic studies enrolling >20 patients and investigating ultrasound, MRI, CT or positron emission tomography (PET) in patients with suspected and/or established primary LVV...
2018: RMD Open
Jérôme Hadjadj, Guillaume Canaud, Tristan Mirault, Maxime Samson, Patrick Bruneval, Alexis Régent, Claire Goulvestre, Véronique Witko-Sarsat, Nathalie Costedoat-Chalumeau, Loïc Guillevin, Luc Mouthon, Benjamin Terrier
Objectives: Takayasu arteritis (TA) and GCA are large-vessel vasculitides characterized by vascular remodelling involving endothelial cells (ECs) and vascular smooth muscle cells. Mammalian target of rapamycin (mTOR) pathway has been involved in vascular remodelling. We hypothesized that the mTOR pathway was involved in the pathogenesis of large-vessel vasculitis. Methods: We used IF analysis on aortic and temporal artery biopsies from patients with TA and GCA to assess the involvement of the mTOR pathway and searched for antibodies targeting ECs in serum by IIF and cellular ELISA...
February 27, 2018: Rheumatology
Nicolai Leuchten, Martin Aringer
Giant cell arteritis is a systemic vasculitis of large vessels, manifesting mainly as temporal arteritis or large vessel vasculitis of the aorta and its branches. Glucocorticoid therapy is essential and so far had to be continued over a period of 1.5-2 years, resulting in relevant morbidity through adverse effects. With the approval of tocilizumab, an effective glucocorticoid sparing option is now available. In two randomized controlled trials, a profound reduction of cumulative glucocorticoid dose, prolonged relapse-free remission and reduced number of adverse events in the treatment groups have been demonstrated...
March 5, 2018: Immunotherapy
V M Pachón-Garrudo, J J Martín-Marcuartu, Á de Bonilla-Damiá, J M Jiménez-Hoyuela-García
No abstract text is available yet for this article.
February 28, 2018: Revista Española de Medicina Nuclear e Imagen Molecular
Nima Moghaddam, Bahar Moghaddam, Natasha Dehghan, Nathan W Brunner
No abstract text is available yet for this article.
January 1, 2018: Pulmonary Circulation
Judy Savige, Michelle Trevisin, Wendy Pollock
Testing for antineutrophil cytoplasmic antibodies (ANCA) is performed to diagnose or exclude small vessel vasculitis, and, in treated patients, to monitor disease activity. However testing is also undertaken to assist with the diagnosis of other autoimmune diseases and some infections. Most laboratories use the same assays for all sera regardless of the testing indications. The International Consensus Statement on ANCA Testing and Reporting recommended screening for ANCA by indirect immunofluorescence (IIF) and confirming IIF-positive sera in antigen-specific ELISAs for both proteinase 3 (PR3) and myeloperoxidase (MPO)...
February 24, 2018: Journal of Immunological Methods
Masahiro Yamasaki, Takuya Sawabe, Masaya Taniwaki, Noboru Hattori
No abstract text is available yet for this article.
February 20, 2018: QJM: Monthly Journal of the Association of Physicians
Satoru Ide, Shingo Kakeda, Mari Miyata, Shigeru Iwata, Naoaki Ohkubo, Shingo Nakayamada, Koichiro Futatsuya, Keita Watanabe, Junji Moriya, Yoshihisa Fujino, Yoshiya Tanaka, Yukunori Korogi
BACKGROUND: Systemic lupus erythematosus (SLE) is related to vasculitis, which causes brain infarctions; however, the pathology of large cerebral vessels has not been fully established. PURPOSE: To demonstrate the prevalence of vessel wall lesions (VWLs) in SLE patients using 3D vessel wall imaging and to assess the relationship between VWLs and brain infarctions. STUDY TYPE: Retrospective. SUBJECTS: Sixty SLE patients and 50 healthy subjects (HS)...
February 23, 2018: Journal of Magnetic Resonance Imaging: JMRI
Jason Michael Springer, Paul Monach, David Cuthbertson, Simon Carette, Nader A Khalidi, Carol A McAlear, Christian Pagnoux, Philip Seo, Kenneth J Warrington, Steven R Ytterberg, Gary Hoffman, Carol Langford, Thomas Hamilton, Dirk Foell, Thomas Vogl, Dirk Holzinger, Peter A Merkel, Johannes Roth, Rula A Hajj-Ali
No abstract text is available yet for this article.
February 22, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
Tharsika Kuganesan, Allen R Huang
BACKGROUND: Giant cell arteritis (GCA) is an immune mediated inflammatory disease of medium and large arteries which afflicts older people. The classical presentation features include: headache, visual disturbances, and jaw claudication. Patients diagnosed with GCA have also been observed to be at higher risk for the subsequent development of strokes. CASE PRESENTATION: We describe a case of an 84-year old right-handed man who presented to hospital with dysarthria, dysphagia, right-sided facial drop, a history of generalized weakness and multiple falls...
February 21, 2018: BMC Geriatrics
Volkan Yuksel, Orkut Guclu, Ebru Tastekin, Umit Halici, Serhat Huseyin, Volkan Inal, Suat Canbaz
OBJECTIVE: Temporal arteritis is systemic vasculitis of medium and large sized vessels. The lowest incidence rates were reported in Turkey, Japan and Israel. We aimed to investigate the results of patients with biopsy-proven temporal arteritis and those classified according to the American College of Rheumatology criteria from a low-incidence region for temporal arteritis. The results of our study are noteworthy, since there is limited data on pathologic diagnosis of temporal arteritis in Turkey...
November 2017: Revista da Associação Médica Brasileira
Amrutha Lakshmi Rayudu, Tekchand Kalawat, V S Krishna Mohan, A Mohan, Amancharla Yadagiri Lakshmi, Ranadheer Gupta Mantri
18F-fluorodeoxyglucose positron emission tomography-computed tomography (18F-FDG PET-CT) is a rapidly evolving hybrid imaging technique in evaluation of infection and inflammation. Usually, functional changes often precede anatomical changes. 18F-FDG PET-CT, a noninvasive diagnostic test and it is useful for the early detection of inflammation. Most of the large vessel vasculitis patients present with nonspecific signs and symptoms, which are difficult to diagnose clinically. Here, we discuss three cases of large vessel vasculitis with different clinical presentations, identified by 18F-FDG PET-CT scan...
January 2018: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
Angela Mujukian, Michael Kay, Jonathan Lewis Marks
No abstract text is available yet for this article.
January 26, 2018: BMJ Case Reports
Susann-Cathrin Olthof, Patrick Krumm, Jörg Henes, Konstantin Nikolaou, Christian la Fougère, Christina Pfannenberg, Nina Schwenzer
PURPOSE: To define the most appropriate imaging parameters in combined Fluorodeoxyglucose (FDG) PET/CT reflecting the inflammatory burden in large vessel vasculitis. METHODS: Two readers retrospectively graded disease extent and activity in 17 LVV patients using visual and quantitative scores in FDG PET and contrast enhanced CT. Visual PET scores were assessed corresponding to FDG-uptake vs. liver uptake (score 0-3). CT visual scoring referred to the affected vessel extent (score 1-5)...
February 2018: European Journal of Radiology
Christian Dejaco, Sofia Ramiro, Christina Duftner, Florent L Besson, Thorsten A Bley, Daniel Blockmans, Elisabeth Brouwer, Marco A Cimmino, Eric Clark, Bhaskar Dasgupta, Andreas P Diamantopoulos, Haner Direskeneli, Annamaria Iagnocco, Thorsten Klink, Lorna Neill, Cristina Ponte, Carlo Salvarani, Riemer H J A Slart, Madeline Whitlock, Wolfgang A Schmidt
To develop evidence-based recommendations for the use of imaging modalities in primary large vessel vasculitis (LVV) including giant cell arteritis (GCA) and Takayasu arteritis (TAK).European League Against Rheumatism (EULAR) standardised operating procedures were followed. A systematic literature review was conducted to retrieve data on the role of imaging modalities including ultrasound, MRI, CT and [18 F]-fluorodeoxyglucose positron emission tomography (PET) in LVV. Based on evidence and expert opinion, the task force consisting of 20 physicians, healthcare professionals and patients from 10 EULAR countries developed recommendations, with consensus obtained through voting...
January 22, 2018: Annals of the Rheumatic Diseases
Pouria Parsa, Anthony Rios, Lisa N Anderson, John F Eidt, Dennis Gable, Brad Grimsley
Giant cell arteritis is a large- and medium-vessel vasculitis that has been described as a systemic disease process with disseminated vessel involvement. Advances in vascular imaging techniques have demonstrated that involvement of the large vessels of the upper and lower limbs may be more prevalent than was once thought, although the clinical implications of this are unknown. Isolated lower extremity claudication without systemic or classic cranial symptoms, especially as a primary manifestation of giant cell arteritis, is rare...
September 2017: Journal of Vascular Surgery Cases and Innovative Techniques
Pietro Enea Lazzerini, Iacopo Bertolozzi, Maurizio Acampa, Rosella Fulceri, Franco Laghi-Pasini, Pier Leopoldo Capecchi
Polymyalgia rheumatica (PMR) represents the most common inflammatory rheumatic disease of the elderly. It is characterized by synovitis of proximal joints and extra-articular synovial structures, along with chronic high-grade systemic inflammation. PMR is closely related to giant cell arteritis (GCA), a large-vessel vasculitis that involves the major branches of the aorta, particularly the extracranial branches of carotid artery including temporal arteries. It is currently believed that PMR and GCA may represent different manifestations of the same disease process...
January 10, 2018: Current Pharmaceutical Design
H Elsayed Mansour, S Gamal Arafa, W Abdelfatah Shehata
A 30-year-old female presented to the rheumatology outpatient clinic of the Internal Medicine Department, Ain Shams University Hospital, Cairo, Egypt, complaining of a large right leg ulcer consistent with pyoderma gangrenosum. There was history of recurrent attacks of bleeding per rectum of one-year duration. During hospitalization she noticed blurring of vision in the left eye with diffuse blackish discoloration of the feet and toes, consistent with small-vessel vasculitis. Colonoscopy with biopsy and histopathology confirmed the diagnosis of inflammatory bowel disease-ulcerative colitis (IBD-UC)...
January 1, 2018: Lupus
M A Cimmino, D Camellino
Not available.
December 21, 2017: Reumatismo
Jung Woo Kwon, Min Ki Hong, Bo Young Park
BACKGROUND: Symmetrical peripheral gangrene (SPG) is an uncommon syndrome showing symmetrical gangrene in acral regions without evidence of large-vessel occlusion or vasculitis. Intravenous vasopressors are frequently used to manage hemodynamically unstable patients. There have been few reports about SPG after using inotropics. However, risk factors for SPG have not been extensively studied. Therefore, the objective of this study was to analyze several cases of SPG and identify risk factors for SPG...
January 9, 2018: Annals of Plastic Surgery
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