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Large vessel vasculitis

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https://www.readbyqxmd.com/read/29776658/ustekinumab-for-refractory-giant-cell-arteritis-a-prospective-52-week-trial
#1
Richard Conway, Lorraine O'Neill, Phil Gallagher, Geraldine M McCarthy, Conor C Murphy, Douglas J Veale, Ursula Fearon, Eamonn S Molloy
OBJECTIVES: Giant cell arteritis (GCA) is the most common form of systemic vasculitis. Glucocorticoids are an effective treatment but have significant adverse events and relapses are common. Interleukins 12 (IL-12) and 23 (IL-23) stimulate TH 1 and TH 17 responses and are implicated in the pathogenesis of GCA. The aim of this study was to evaluate the efficacy and safety of IL-12/23 blockade with ustekinumab in GCA. METHODS: We performed a prospective open label study of ustekinumab in patients with refractory GCA...
April 22, 2018: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29746000/pericarditis-among-giant-cell-arteritis-patients-from-myth-to-reality
#2
Shmuel Tiosano, Yehuda Adler, Shir Azrielant, Yarden Yavne, Omer Gendelman, Dana Ben-Ami Shor, Doron Comaneshter, Guy Shalom, Arnon D Cohen, Howard Amital
BACKGROUND: Giant cell arteritis (GCA) is an inflammatory disease of unknown etiology affecting adults age > 50 years. GCA (also known as temporal arteritis) is a vasculitis of large and medium-size vessels that involves the extracranial branches of the carotid artery. Common manifestations include constitutional symptoms, headache, jaw claudication, scalp tenderness, and vision loss. Cardiac involvement in GCA is considered to be as low as 5%, and < 30 cases of pericarditis among GCA patients have been reported in the literature...
May 10, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29729443/positron-emission-tomography-pet-and-single-photon-emission-computed-tomography-spect-imaging-of-macrophages-in-large-vessel-vasculitis-current-status-and-future-prospects
#3
REVIEW
William Febry Jiemy, Peter Heeringa, Jan A A M Kamps, Conny J van der Laken, Riemer H J A Slart, Elisabeth Brouwer
Macrophages are key players in the pathogenesis of large-vessel vasculitis (LVV) and may serve as a target for diagnostic imaging of LVV. The radiotracer, 18 F-FDG has proven to be useful in the diagnosis of giant cell arteritis (GCA), a form of LVV. Although uptake of 18 F-FDG is high in activated macrophages, it is not a specific radiotracer as its uptake is high in any proliferating cell and other activated immune cells resulting in high non-specific background radioactivity especially in aging and atherosclerotic vessels which dramatically lowers the diagnostic accuracy...
May 2, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29701396/takayasus-s-aortitis-induced-ascending-aorta-dissection
#4
Bruno Fernandes, Joana Saraiva, Lina Carvalho
INTRODUCTION: Takayasu aortitis is a well known yet rare form of large vessel vasculitis. Also known as pulseless disease, occlusive thromboaortopathy, and Martorell syndrome, is a chronic inflammatory aortitis. Vessel inflammation leads to wall thickening, fibrosis, stenosis, and thrombus formation. METHODS: A 64-year-old woman was referred to emergency for lack of pulse in the upper and lower limbs and changes in heart rate. AngioRMN revealed dissection of the ascending aorta while in PET, intense uptake of FDG-F18 involving ascending, crossa, descending thoracic and abdominal segments of the aorta, was evident urgent surgical correction occurred...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29701393/igg4-disease-and-slerosing-aortitis
#5
Bruno Fernandes, Rui Anacleto, Lina Carvalho
INTRODUCTION: IgG4-related disease (IgG4-RD) is an immune- -mediated fibro-inflammatory condition with unknown etiology that can affect various organs. Although its prevalence is still unknown, it appears to be more frequent in adult males. Cardiovascular manifestations are rare and can include idiopathic retroperitoneal periaortic fibrosis, inflammatory aortic aneurism, inflammatory periarteritis and inflammatory pericarditis. Vascular involvement is a well-recognized feature and large vessel commitment, especially the aorta, can be the only manifestation of the disease...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29690555/concomitant-polymyalgia-rheumatica-and-large-vessel-vasculitis-visualized-on-18-f-fdg-pet-ct
#6
Jane Maestri Brittain, Lars Christian Gormsen, Eric von Benzon, Kim Francis Andersen
Polymyalgia rheumatica (PMR) and large-vessel vasculitis (LVV) are related rheumatic diseases which are occasionally present concomitantly. PMR is characterized by synovitis and bursitis. In LVV, inflammation of the blood vessel wall is seen. Both disorders can be difficult to diagnose since patients often present non-specific symptoms and results of blood tests. The non-specific symptoms cannot always be distinguished from symptoms indicating an occult malignancy. We present a case of PMR and LVV in a Scandinavian man visualized on [18 F]-2-deoxy-D-glucose positron emission tomography/computed tomography (18 F-FDG PET/CT) with the presentation of typically affected sites of joints and arteries and with the same imaging modality ruling out occult malignancy...
April 22, 2018: Diagnostics
https://www.readbyqxmd.com/read/29676201/prognosis-and-monitoring-of-giant-cell-arteritis-and-associated-complications
#7
Tanaz A Kermani, Kenneth J Warrington
Giant cell arteritis (GCA) is the most common systemic vasculitis in people over the age of 50 years. Prospective imaging studies in GCA highlight the systemic nature of this vasculitis. Areas covered: This review summarizes literature using PubMed on complications of GCA and its treatment. Emphasis was placed on articles published within the past 5 years. Disease associated complications including vision loss from arteritic anterior ischemic optic neuropathy, large-artery stenoses and ischemia, and, aortic aneurysms and dissections...
April 26, 2018: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/29671039/three-days-of-high-dose-glucocorticoid-treatment-attenuates-large-vessel-18f-fdg-uptake-in-large-vessel-giant-cell-arteritis-but-with-a-limited-impact-on-diagnostic-accuracy
#8
Berit Dalsgaard Nielsen, Lars Christian Gormsen, Ib Tønder Hansen, Kresten Krarup Keller, Philip Therkildsen, Ellen-Margrethe Hauge
PURPOSE: To evaluate the in-treatment diagnostic accuracy of FDG PET/CT in large-vessel giant cell arteritis (LV-GCA) by serial scans before and after a short course of high-dose glucocorticoid treatment. METHODS: Twenty-four glucocorticoid-naïve patients with new-onset PET/CT verified LV-GCA (pre-treatment baseline PET) were prospectively included. Excluded were patients with a previous history of GCA or polymyalgia rheumatica, LV-GCA-mimicking conditions and patients on immunosuppressive therapy...
April 18, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29666047/comparison-of-magnetic-resonance-angiography-and-18-f-fluorodeoxyglucose-positron-emission-tomography-in-large-vessel-vasculitis
#9
Kaitlin A Quinn, Mark A Ahlman, Ashkan A Malayeri, Jamie Marko, Ali Cahid Civelek, Joel S Rosenblum, Armin A Bagheri, Peter A Merkel, Elaine Novakovich, Peter C Grayson
OBJECTIVES: To assess agreement between interpretation of magnetic resonance angiography (MRA) and 18 F-fluorodeoxyglucose positron emission tomography (PET) for disease extent and disease activity in large-vessel vasculitis (LVV) and determine associations between imaging and clinical assessments. METHODS: Patients with giant cell arteritis (GCA), Takayasu's arteritis (TAK) and comparators were recruited into a prospective, observational cohort. Imaging and clinical assessments were performed concurrently, blinded to each other...
April 17, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29653415/carotid-arteritis-causing-amaurosis-fugax-and-ischaemic-cerebrovascular-events-in-neurosarcoidosis
#10
D P Kidd, D J McCabe, T Wilhelm, M Galloway
OBJECTIVE: To present and review the vascular consequences of arteritis in neurosarcoidosis. PATIENT AND METHODS: neurosarcoidosis is typically an inflammatory disorder of the meninges surrounding the brain and spinal cord. Although inflammation of small and medium sized vessels is seen pathologically and vasculitis is occasionally described, a large intracerebral arteritis has not previously been reported. A few case reports exist, however, which describe the vascular consequences of large vessel compromise in the disorder...
March 22, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29611005/recent-advances-in-giant-cell-arteritis
#11
REVIEW
M Guevara, C S Kollipara
PURPOSE OF REVIEW: Giant cell arteritis (GCA) is the most common systemic vasculitis. GCA is categorized as a granulomatous vasculitis of large and medium size vessels. Majority of the symptoms and signs of GCA result from involvement of the aorta and its branches intra- and extracranial. Temporal artery biopsy continues to be the cardinal diagnostic procedure despite new imaging modalities for diagnosing GCA with cranial involvement. Great advances in awareness have led to improvement in preventing irreversible vision loss due to early diagnosis...
April 2, 2018: Current Rheumatology Reports
https://www.readbyqxmd.com/read/29607753/histopathology-of-cutaneous-inflammatory-disorders-in-children
#12
Andy C Hsi, Ilana S Rosman
Inflammatory dermatoses encompass a variety of histologic patterns that affect different portions of the skin. In spongiotic, psoriasiform, lichenoid, pityriasiform, and blistering disorders, there are predominately epidermal and junctional activities with variable superficial dermal inflammation. Hypersensitivity reactions can show either epidermal or mostly dermal changes depending on whether the exposure of the exogenous allergen occurs through an external or internal route, respectively. Exceptions include erythema multiforme and Stevens-Johnson syndrome/toxic epidermal necrolysis, where the etiology is often due to infection or ingested medications, but the histologic features are almost exclusively confined to the epidermis and dermoepidermal junction...
March 2018: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/29600479/ct-analysis-of-the-aorta-in-giant-cell-arteritis-a-case-control-study
#13
Pierre Emmanuel Berthod, Serge Aho-Glélé, Paul Ornetti, Olivier Chevallier, Hervé Devilliers, Frédéric Ricolfi, Bernard Bonnotte, Romaric Loffroy, Maxime Samson
OBJECTIVES: Giant cell arteritis (GCA) is a large-vessel vasculitis whose diagnosis is confirmed by temporal artery biopsy. However, involvement of large vessels, especially the aorta, can be shown by imaging, which plays an increasing role in GCA diagnosis. The threshold above which aortic wall thickening, as measured by computed tomography (CT), is considered pathological is controversial, with values ranging from 2 to 3 mm. This study assessed aortic morphology by CT scan and its diagnostic value in GCA...
March 29, 2018: European Radiology
https://www.readbyqxmd.com/read/29599785/cd1d-restricted-type-ii-nkt-cells-reactive-with-endogenous-hydrophobic-peptides
#14
REVIEW
Yusuke Nishioka, Sakiko Masuda, Utano Tomaru, Akihiro Ishizu
NKT cells belong to a distinct subset of T cells that recognize hydrophobic antigens presented by major histocompatibility complex class I-like molecules, such as CD1d. Because NKT cells stimulated by antigens can activate or suppress other immunocompetent cells through an immediate production of a large amount of cytokines, they are regarded as immunological modulators. CD1d-restricted NKT cells are classified into two subsets, namely, type I and type II. CD1d-restricted type I NKT cells express invariant T cell receptors (TCRs) and react with lipid antigens, including the marine sponge-derived glycolipid α-galactosylceramide...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29570475/tocilizumab-in-giant-cell-arteritis
#15
Vincent J Mariano, William H Frishman
Giant cell arteritis is a granulomatous immune-mediated vasculitis of medium and large vessels. It most commonly affects Caucasian females over the age of 50 and is the most common primary vasculitis in the United States. Treatment of this disease has classically been with high-dose corticosteroids, but this therapy has been associated with severe morbidity and mortality. Tocilizumab, a humanized monoclonal antibody targeting the interleukin-6 receptor, has been used with great efficacy and safety in rheumatoid arthritis and systemic-onset juvenile idiopathic arthritis...
March 22, 2018: Cardiology in Review
https://www.readbyqxmd.com/read/29550251/18-f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-in-patients-with-polymyalgia-rheumatica-screening-for-vasculitis
#16
Karla Arévalo Ruales, Rosa Negueroles Albuixech, José Loaiza Gongora, Elena Grau García, José Ivorra Cortés, José A Román Ivorra
OBJECTIVE: Polymyalgia rheumatica (PR) can be associated with large vessel vasculitis (LVV). We evaluate the diagnostic role of 18 F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) and its impact on the treatment of LVV associated with PR. MATERIALS AND METHODS: Retrospective study of patients diagnosed with PR. Data was collected from health records. Blood analysis included acute-phase reactants (APR), C-reactive protein (CRP) and erythrocyte sedimentation rate...
March 14, 2018: Reumatología Clinica
https://www.readbyqxmd.com/read/29531788/imaging-in-diagnosis-outcome-prediction-and-monitoring-of-large-vessel-vasculitis-a-systematic-literature-review-and-meta-analysis-informing-the-eular-recommendations
#17
Christina Duftner, Christian Dejaco, Alexandre Sepriano, Louise Falzon, Wolfgang Andreas Schmidt, Sofia Ramiro
Objectives: To perform a systematic literature review on imaging techniques for diagnosis, outcome prediction and disease monitoring in large vessel vasculitis (LVV) informing the European League Against Rheumatism recommendations for imaging in LVV. Methods: Systematic literature review (until 10 March 2017) of diagnostic and prognostic studies enrolling >20 patients and investigating ultrasound, MRI, CT or positron emission tomography (PET) in patients with suspected and/or established primary LVV...
2018: RMD Open
https://www.readbyqxmd.com/read/29506143/mtor-pathway-is-activated-in-endothelial-cells-from-patients-with-takayasu-arteritis-and-is-modulated-by-serum-immunoglobulin-g
#18
Jérôme Hadjadj, Guillaume Canaud, Tristan Mirault, Maxime Samson, Patrick Bruneval, Alexis Régent, Claire Goulvestre, Véronique Witko-Sarsat, Nathalie Costedoat-Chalumeau, Loïc Guillevin, Luc Mouthon, Benjamin Terrier
Objectives: Takayasu arteritis (TA) and GCA are large-vessel vasculitides characterized by vascular remodelling involving endothelial cells (ECs) and vascular smooth muscle cells. Mammalian target of rapamycin (mTOR) pathway has been involved in vascular remodelling. We hypothesized that the mTOR pathway was involved in the pathogenesis of large-vessel vasculitis. Methods: We used IF analysis on aortic and temporal artery biopsies from patients with TA and GCA to assess the involvement of the mTOR pathway and searched for antibodies targeting ECs in serum by IIF and cellular ELISA...
February 27, 2018: Rheumatology
https://www.readbyqxmd.com/read/29504436/tocilizumab-in-the-treatment-of-giant-cell-arteritis
#19
Nicolai Leuchten, Martin Aringer
Giant cell arteritis is a systemic vasculitis of large vessels, manifesting mainly as temporal arteritis or large vessel vasculitis of the aorta and its branches. Glucocorticoid therapy is essential and so far had to be continued over a period of 1.5-2 years, resulting in relevant morbidity through adverse effects. With the approval of tocilizumab, an effective glucocorticoid sparing option is now available. In two randomized controlled trials, a profound reduction of cumulative glucocorticoid dose, prolonged relapse-free remission and reduced number of adverse events in the treatment groups have been demonstrated...
March 1, 2018: Immunotherapy
https://www.readbyqxmd.com/read/29501403/extent-large-vessel-vasculitis-diagnosed-with-18-f-fdg-pet-ct
#20
V M Pachón-Garrudo, J J Martín-Marcuartu, Á de Bonilla-Damiá, J M Jiménez-Hoyuela-García
No abstract text is available yet for this article.
February 28, 2018: Revista Española de Medicina Nuclear e Imagen Molecular
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