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JOURNAL ARTICLE
M Röhrich, J J Rosales, J Hoppner, P Kvacskay, N Blank, L Loi, D Paech, M Schreckenberger, F Giesel, H U Kauczor, H M Lorenz, U Haberkorn, W Merkt
OBJECTIVES: Epigenetically modified fibroblasts contribute to chronicity in inflammatory diseases. Reasons for the relapsing character of large vessel vasculitis (LVV) remain obscure, including the role of fibroblasts, in part due to limited access to biopsies of involved tissue.68Ga FAPI-46 (FAPI)-PET/CT detects activated fibroblasts in vivo. In this exploratory pilot study, we tested the detection of fibroblast activation in vessel walls using FAPI-PET/CT in LVV with aortitis. METHODS: 8 LVV patients with aortitis and 8 age- and gender-matched controls were included...
April 22, 2024: Rheumatology
#2
JOURNAL ARTICLE
P Vaideeswar, G Sabnis
Acute rheumatic fever and Takayasu arteritis are examples of autoimmune diseases that commonly affect the cardiovascular system. We report an infrequent co-occurrence of both these diseases in an adolescent male. It may appear that in some individuals, the rheumatic fever may act as a trigger for the development of large vessel vasculitis. This possibility should be considered in patients on follow-up if they develop fresh features of cardiovascular compromise despite appropriate medical, interventional, or surgical therapy for rheumatic heart disease...
April 17, 2024: Journal of Postgraduate Medicine
#3
JOURNAL ARTICLE
Anne-Claire Billet, Thomas Thibault, Éric Liozon, Hubert De Boysson, Laurent Perard, Olivier Espitia, Aurélie Daumas, Quentin Gomes De Pinho, Cécile-Audrey Durel, Arnaud Hot, Boris Bienvenu, Sébastien Humbert, Claude Bachmeyer, Sabine Mainbourg, Thomas Sené, Hervé Devilliers, Bastien Durand Bailloud, Hélène Greigert, Alexandre Cochet, Bernard Bonnotte, Jean-Louis Alberini, Maxime Samson
OBJECTIVES: To evaluate the ability of 18 FDG PET/CT, at diagnosis of giant cell arteritis (GCA) and during follow-up, to predict occurrence of relapse in large-vessel GCA (LV-GCA). METHODS: We conducted a retrospective study using the French Study Group for Large-Vessel Vasculitis (GEFA) network. Data from patients with LV-GCA diagnosed by PET/CT and who had PET/CT in the following year were collected. For each PET/CT, PET vascular activity score (PETVAS) and total vascular score (TVS) were assessed, and their ability to predict the occurrence of subsequent relapse was assessed...
April 15, 2024: European Journal of Internal Medicine
#4
JOURNAL ARTICLE
Tayfun Hilmi Akbaba, Kirandeep K Toor, Simranpreet K Mann, Kristen M Gibson, Gabriel Alejandro Alfaro, Banu Balci-Peynircioglu, David A Cabral, Kimberly A Morishita, Kelly L Brown
Chronic primary systemic vasculitis (PSV) comprises a group of heterogeneous diseases that are broadly classified by affected blood vessel size, clinical traits and the presence (or absence) of anti-neutrophil cytoplasmic antibodies (ANCA) against proteinase 3 (PR3) and myeloperoxidase (MPO). In small vessel vasculitis (SVV), ANCA are not present in all patients, and they are rarely detected in patients with vasculitis involving medium (MVV) and large (LVV) blood vessels. Some studies have demonstrated that lysosome-associated membrane protein-2 (LAMP-2/CD107b) is a target of ANCA in SVV, but its presence and prognostic value in childhood MVV and LVV is not known...
March 28, 2024: International Journal of Molecular Sciences
#5
REVIEW
Yuki Sato, Maria Tada, Jorg J Goronzy, Cornelia M Weyand
Giant cell arteritis (GCA) is a prototypic autoimmune disease with a highly selective tissue tropism for medium and large arteries. Extravascular GCA manifests with intense systemic inflammation and polymyalgia rheumatica; vascular GCA results in vessel wall damage and stenosis, causing tissue ischemia. Typical granulomatous infiltrates in affected arteries are composed of CD4+ T cells and hyperactivated macrophages, signifying the involvement of the innate and adaptive immune system. Lesional CD4+ T cells undergo antigen-dependent clonal expansion, but antigen-nonspecific pathways ultimately control the intensity and duration of pathogenic immunity...
April 9, 2024: Best Practice & Research. Clinical Rheumatology
#6
JOURNAL ARTICLE
Yoshiyuki Abe, Takao Fujii, Yoshia Miyawaki, Takahiko Sugihara, Haruhito A Uchida, Yasuhiro Maejima, Yoshiko Watanabe, Takuya Hashimoto, Takako Miyamae, Yoshikazu Nakaoka, Masayoshi Harigai, Naoto Tamura
OBJECTIVES: To access the real-world clinical management of physicians who treat Takayasu arteritis (TAK) and giant cell arteritis (GCA) after the publication of the Japanese Circulation Society (JCS) 2017 Guidelines for the Management of Vasculitis Syndrome. METHODS: This descriptive, cross-sectional study utilized self-administered electronic questionnaires, which were answered in February 2022 by physicians treating TAK or GCA and registered with Macromill Inc...
April 8, 2024: Modern Rheumatology
#7
JOURNAL ARTICLE
Ulf Schönermarck, Bernhard Hellmich, Elena Csernok
The diagnosis of systemic vasculitis (SV) is a major clinical challenge due to the very different forms of presentation and requires an interdisciplinary approach. Targeted laboratory diagnostics support making the diagnosis, differential diagnosis and classification and are also a key component in the detection of active organ manifestations and treatment complications. The basic laboratory tests include the erythrocyte sedimentation rate (ESR), C‑reactive protein (CRP), blood count, serum creatinine, urinalysis, specific autoantibodies, complement, immunoglobulins, cryoglobulins and hepatitis B and C serology...
April 8, 2024: Zeitschrift Für Rheumatologie
#8
Adugna Lamessa, Abdi Birhanu, Gashahun Mekonnen, Abdulkadir Mohammed, Tamirat Godebo Woyimo, Elsah Tegene Asefa
Takayasu arteritis (TAK) is a rare large-vessel vasculitis of unknown etiology that leads to arterial wall thickening, stenosis, and occlusion, which may complicate cerebrovascular ischemic events. Ischemic stroke is a potentially devastating complication of TAK at a young age, but the occurrence is still rarely reported in Ethiopia. Although it occurs late in the course of the condition, it may be the initial presentation and suggest an unfavorable prognosis. Herein, we address the case of a 25-year-old woman who presented to a university hospital while on follow-up after 2 years of stroke with deterioration in clinical symptoms, absent brachial artery pulses, and unrecordable blood pressure in both arms...
2024: SAGE Open Medical Case Reports
#9
JOURNAL ARTICLE
Sophie Gallou, Christian Agard, Anael Dumont, Samuel Deshayes, Jonathan Boutemy, Gwénola Maigné, Nicolas Martin Silva, Alexandre Nguyen, Rémi Philip, Olivier Espitia, Achille Aouba, Hubert de Boysson
OBJECTIVES: To identify factors associated with the progression of giant cell arteritis (GCA)-related or associated aortic dilations. METHODS: In this retrospective study, 47 GCA patients with aortic dilation were longitudinally analyzed. Each patient underwent ≥2 imaging scans of the aorta during the follow-up. Three progression statuses of aortic dilations were distinguished: fast-progressive (FP) defined by a progression of the aortic diameter ≥5 mm/year or ≥1 cm/2 years, slow progressive (SP) by a progression of the aortic diameter >1 mm during the follow-up, and not progressive (NP) when aortic diameter remained stable...
April 5, 2024: European Journal of Internal Medicine
#10
Hitomi Sugino, Hikaru Kawahara, Kayo Yamamoto, Etsuko Okada, Yu Sawada
Pyoderma gangrenosum is a rare inflammatory skin disease classified within the group of neutrophilic dermatoses, and clinically characterised by painful, rapidly evolving cutaneous ulcers with undermined, irregular, erythematous-violaceous edges. Underlying diseases include rheumatoid arthritis, inflammatory bowel disease, haematopoietic malignancy, and aortitis syndrome. However, there was a limited number of cases of concomitant pyoderma gangrenosum and IgA vasculitis. Herein, we report a case presenting persistent large skin wounds as a diagnosis of pyoderma gangrenosum in the setting of IgA cutaneous vasculitis, which was successfully treated by a TNF-α inhibitor...
April 2024: Skin Health Dis
#11
REVIEW
Kornelis S M van der Geest, Maria Sandovici, Thorsten A Bley, James R Stone, Riemer H J A Slart, Elisabeth Brouwer
Giant cell arteritis is the principal form of systemic vasculitis affecting people over 50. Large-vessel involvement, termed large vessel giant cell arteritis, mainly affects the aorta and its branches, often occurring alongside cranial giant cell arteritis, but large vessel giant cell arteritis without cranial giant cell arteritis can also occur. Patients mostly present with constitutional symptoms, with localising large vessel giant cell arteritis symptoms present in a minority of patients only. Large vessel giant cell arteritis is usually overlooked until clinicians seek to exclude it with imaging by ultrasonography, magnetic resonance angiography (MRA), computed tomography angiography (CTA), or [18 F]fluorodeoxyglucose-PET-CT...
March 28, 2024: Lancet Rheumatology
#12
JOURNAL ARTICLE
Daniel Blockmans, Lien Moreel, Albrecht Betrains, Steven Vanderschueren, Walter Coudyzer, Lennert Boeckxstaens, Koen Van Laere
BACKGROUND: A positive PET scan at diagnosis was associated with a greater yearly increase in ascending and descending aortic diameter and thoracic aortic volume in patients with giant cell arteritis (GCA). Radiologic and histopathologic vascular abnormalities persist in a subset of treated patients despite clinical remission. The aim of this study was to evaluate the association between vascular FDG uptake during follow-up and the development of thoracic aortic aneurysms. METHODS: We recently performed a prospective cohort study of 106 GCA patients, who underwent FDG PET and CT imaging at diagnosis and CT imaging yearly for a maximum of 10 years...
2024: Frontiers in Medicine
#13
JOURNAL ARTICLE
Pierre-André Jarrot, Adrien Mirouse, Sébastien Ottaviani, Simon Cadiou, Jean-Hugues Salmon, Eric Liozon, Simon Parreau, Martin Michaud, Benjamin Terrier, Pierre-Edouard Gavand, Ludovic Trefond, Virginie Lavoiepierre, Jeremy Keraen, Daniel Rekassa, Bastien Bouldoires, Thierry Weitten, Damien Roche, Antoine Poulet, Caroline Charpin, Vincent Grobost, Marion Hermet, Magali Pallure, Chloe Wackenheim, Ludovic Karkowski, Pierre Grumet, Thomas Rogier, Nabil Belkefi, Vincent Pestre, Emilie Broquet, Amélie Leurs, Sophie Gautier, Valérie Gras, Pierre Gilet, Jan Holubar, Nadia Sivova, Nicolas Schleinitz, Jean-Marc Durand, Brice Castel, Alexandre Petrier, Robin Arcani, Baptiste Gramont, Philippe Guilpain, Hubert Lepidi, Pierre-Jean Weiller, Joelle Micallef, David Saadoun, Gilles Kaplanski
We conducted a national in-depth analysis including pharmacovigilance reports and clinical study to assess the reporting rate (RR) and to determine the clinical profile of polymyalgia rheumatica (PMR) and giant cell arteritis (GCA) in COVID-19-vaccinated individuals. First, based on the French pharmacovigilance database, we estimated the RR of PMR and GCA cases in individuals aged over 50 who developed their initial symptoms within one month of receiving the BNT162b2 mRNA, mRNA-1273, ChAdOx1 nCoV-19, and Ad26...
December 31, 2024: Human Vaccines & Immunotherapeutics
#14
Sumaya Hussein, Greg Allister, Azeem Ahmed
We present the case of a 73-year-old male with pyrexia of unknown origin (PUO). He was a returned traveller from Southern Africa and underwent extensive investigation to rule out an infective cause. This was mostly unrevealing but there was a notable transaminitis (ALT predominant) with normal bilirubin level. He showed no serological or clinical improvement despite antibiotic treatment. Subsequent CT-PET showed high mural uptake in the thoracic and abdominal aorta and its major branches, confirming the diagnosis of Large Vessel Vasculitis (LVV)...
March 28, 2024: Clinical Medicine: Journal of the Royal College of Physicians of London
#15
JOURNAL ARTICLE
Lien Moreel, Lennert Boeckxstaens, Albrecht Betrains, Timo Smans, Geert Molenberghs, Koen Van Laere, Ellen De Langhe, Steven Vanderschueren, Daniel Blockmans
OBJECTIVES: Two recent meta-analyses reported subclinical vasculitis in 22-23% of patients with polymyalgia rheumatica (PMR). We aimed to evaluate the prevalence, characteristics, and outcome of subclinical vasculitis among our PMR patients. METHODS: Consecutive patients with GCA/PMR spectrum disease with isolated PMR symptoms who underwent FDG PET imaging between 2003-2020 and who were followed for ≥6 months, were included retrospectively. Vasculitis was defined as FDG uptake ≥ grade 2 in any vessel...
March 28, 2024: Rheumatology
#16
REVIEW
Daniela Opriș-Belinski, Claudia Oana Cobilinschi, Ioana Săulescu
Giant cell arteritis (GCA) is a large-vessel vasculitis affecting elderly patients and targeting the aorta and its main branches, leading to cranial and extracranial manifestations. The mechanism behind the ischemia is a granulomatous-type inflammation with potentially critical lesions, including visual loss involving the ophthalmic artery. Despite significant progress in unraveling the pathophysiology of this disease, treatment options still rely on glucocorticoids (GCs) to overcome active vascular lesions and disease flares...
February 26, 2024: Medicina
#17
JOURNAL ARTICLE
Russel Machin, Tom Sulkin, Giles Maskell, Mark Hughes
No abstract text is available yet for this article.
March 27, 2024: Rheumatology
#18
REVIEW
Kornelis S M van der Geest, Olivier Gheysens, Lars C Gormsen, Andor W J M Glaudemans, Charalampos Tsoumpas, Elisabeth Brouwer, Pieter H Nienhuis, Gijs D van Praagh, Riemer H J A Slart
Systemic vasculitides are autoimmune diseases characterized by inflammation of blood vessels. They are categorized based on the size of the preferentially affected blood vessels: large-, medium-, and small-vessel vasculitides. The main forms of large-vessel vasculitis include giant cell arteritis (GCA) and Takayasu arteritis (TAK). Depending on the location of the affected vessels, various imaging modalities can be employed for diagnosis of large vessel vasculitis: ultrasonography (US), magnetic resonance angiography (MRA), computed tomography angiography (CTA), and [18 F]-fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography (FDG-PET/CT)...
March 26, 2024: Seminars in Nuclear Medicine
#19
Masahiro Ito, Masakazu Amari, Akiko Sato, Masahiro Hikichi
Pegylated granulocyte colony-stimulating factor (G-CSF), commonly used in chemotherapy-induced neutropenia, has been associated with rare instances of aortitis. This study describes a 67-year-old female patient with estrogen receptor (ER)-positive, human epidermal growth factor receptor-2-positive breast cancer, undergoing chemotherapy with an epirubicin/cyclophosphamide (EC) regimen (epirubicin, cyclophosphamide) and pegylated G-CSF for neutropenia prophylaxis. Post-treatment, she developed symptoms including intermittent fever and severe arthralgia...
February 2024: Curēus
#20
Omar Ballut, Mayas M Almahi, Banan S Alghamdi, Najla K Alzahrani, Maali A Alghamdi
Behçet disease (BD) is a recurrent, multisystemic autoimmune vasculitis that affects both small and large vessels. A combination of neurological signs and symptoms in BD is called neuro-Behçet syndrome (NBS). We present the case of a 31-year-old male diagnosed with chronic progressive NBS who presented with multiple relapsing episodes concurrent with infective endocarditis due to intravenous drug abuse, drug-induced hepatitis, acute kidney injury, and septic shock that is not related to BD...
February 2024: Curēus
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