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https://www.readbyqxmd.com/read/29793074/cross-linked-electrospun-cartilage-acellular-matrix-poly-caprolactone-co-lactide-co-glycolide-nanofiber-as-an-antiadhesive-barrier
#1
Jin Woo Lee, Joon Yeong Park, Seung Hun Park, Min Ju Kim, Bo Ram Song, Hee-Woong Yun, Tae Woong Kang, Hak Soo Choi, Young Jick Kim, Byoung Hyun Min, Moon Suk Kim
In this work, we chose cartilage acellular matrix (CAM) as a promising antiadhesive material because CAM effectively inhibits the formation of blood vessels, and we used electrospinning to prepare antiadhesive barriers. Additionally, we synthesized N-hydroxysuccinimide (NHS)-poly(caprolactone-co-lactide-co-glycolide)-NHS (MP) copolymers (to tune degradation) as a cross-linking agent for CAM. This is the first report on the development of electrospun cross-linked (Cx) CAM/MP (CA/P) nanofiber (NF) (Cx-CA/P-NF) with a tunable degradation period as an antiadhesive barrier...
May 21, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29792871/cerebral-small-vessel-disease-and-the-risk-of-dementia-a-systematic-review-and-meta-analysis-of-population-based-evidence
#2
REVIEW
Daniel Bos, Frank J Wolters, Sirwan K L Darweesh, Meike W Vernooij, Frank de Wolf, M Arfan Ikram, Albert Hofman
INTRODUCTION: Cerebral small vessel disease is increasingly linked to dementia. METHODS: We systematically searched Medline, Embase, and Cochrane databases for prospective population-based studies addressing associations of white matter hyperintensities, covert brain infarcts (i.e., clinically silent infarcts), and cerebral microbleeds with risk of all-dementia or Alzheimer's disease and performed meta-analyses. RESULTS: We identified 11 studies on white matter hyperintensities, covert brain infarcts, or cerebral microbleeds with risk of all-dementia or Alzheimer's disease...
May 21, 2018: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/29792404/culotte-stenting-for-coronary-bifurcation-lesions-with-2nd-and-3rd-generation-everolimus-eluting-stents-the-celtic-bifurcation-study
#3
Simon J Walsh, Colm G Hanratty, Stuart Watkins, Keith G Oldroyd, Niall T Mulvihill, Mark Hensey, Alex Chase, Dave Smith, Nick Cruden, James C Spratt, Darren Mylotte, Tom Johnson, Jonathan Hill, Hafiz M Hussein, Kris Bogaerts, Marie-Claude Morice, David P Foley
AIMS: The aim of this study was to provide contemporary outcome data for patients with de novo coronary disease and Medina 1,1,1 lesions who were treated with a culotte two-stent technique, and to compare the performance of two modern-generation drug-eluting stent (DES) platforms, the 3-connector XIENCE and the 2-connector SYNERGY. METHODS AND RESULTS: Patients with Medina 1,1,1 bifurcation lesions who had disease that was amenable to culotte stenting were randomised 1:1 to treatment with XIENCE or SYNERGY DES...
May 24, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29792402/bioabsorbable-polymer-everolimus-eluting-stents-in-patients-with-acute-myocardial-infarction-a-report-from-the-swedish-coronary-angiography-and-angioplasty-registry
#4
Sergio Buccheri, Giovanna Sarno, Bo Lagerqvist, Göran Olivecrona, Kristina Hambraeus, Nils Witt, Daniel Lindholm, David Erlinge, Oskar Angerås, Stefan James
AIMS: The clinical performance of the SYNERGY drug-eluting stent (DES) in patients with acute myocardial infarction (MI) has not been investigated in detail. We sought to report on the outcomes after SYNERGY DES (Boston Scientific, Marlborough, MA, USA) implantation in patients with MI undergoing percutaneous revascularisation (PCI). METHODS AND RESULTS: We included all consecutive patients with MI undergoing PCI with the SYNERGY DES and newer-generation DES (n-DES group) in Sweden...
May 24, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29792350/management-of-veins-during-microvascular-decompression-for-idiopathic-trigeminal-neuralgia
#5
Xu Zhao, Shuai Hao, Minqing Wang, Chao Han, Deguang Xing, Chengwei Wang
OBJECT: To summarize our experience in treating veins during microvascular decompression (MVD) procedures for idiopathic trigeminal neuralgia (TN). METHODS: A total of 210 patients who underwent single MVD for idiopathic TN were retrospectively studied. The offending vessels were summarized. The treatment choices for veins during the operation were reviewed. Postoperative long-term outcomes were determined by follow-up. RESULTS: Veins accounted for 26...
May 24, 2018: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/29792349/pulmonary-endothelial-permeability-and-tissue-fluid-balance-depend-on-the-viscosity-of-the-perfusion-solution
#6
Simon C Rowan, Keith D Rochfort, Lucie Piouceau, Philip M Cummins, Malachy O'Rourke, Paul McLoughlin
Fluid filtration in the pulmonary microcirculation depends on the hydrostatic and oncotic pressure gradients across the endothelium, and the selective permeability of the endothelial barrier. Maintaining normal fluid balance depends both on specific properties of the endothelium and of the perfusing blood. Although some of the essential properties of blood needed to prevent excessive fluid leak have been identified and characterised, our understanding of these remains incomplete. The role of perfusate viscosity in maintaining normal fluid exchange has not previously been examined...
May 24, 2018: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/29792089/retrieval-of-a-migrated-n-butyl-2-cyanoacrylate-cast-using-a-snare-kit-system-during-dural-avf-embolization-a-case-report
#7
Ramy Ahmed, Satomi Ide, Hiro Kiyosue, Shuichi Tanoue, Shunro Matsumoto, Hiromu Mori
N-butyl-2 cyanoacrylate (NBCA) is a liquid embolic material that is widely used in various endovascular procedures because of its permanent and rapid vascular occluding effect regardless of the coagulation profile of the patient. However, NBCA migration to unintended vessels may result in serious complications. This report describes the retrieval of a migrated NBCA cast from the transverse-sigmoid sinus during dural arteriovenous fistula embolization using a transvenous snaring technique.
January 1, 2018: Interventional Neuroradiology
https://www.readbyqxmd.com/read/29791972/laparoscopic-radical-nephrectomy-for-a-right-renal-tumor-with-renal-vein-tumor-thrombus-in-a-patient-with-situs-inversus-totalis
#8
Jun Ito, Yasuhiro Kaiho, Hiromichi Iwamura, Go Anan, Makoto Sato
Situs inversus totalis (SIT) is a rare congenital anomaly characterized by complete inversion of the thoracic and abdominal organs. Many intra-abdominal and vessel anomalies have been reported in association with SIT. However, there have been no reports on the use of laparoscopic radical nephrectomy with thrombectomy for renal vein thrombus, which is considered as a safe and feasible procedure, in patients with SIT. We herein present the case of an 80-year-old man with SIT who was preoperatively diagnosed with a right renal tumor and renal vein tumor thrombus...
May 23, 2018: Asian Journal of Endoscopic Surgery
https://www.readbyqxmd.com/read/29791764/synergy-between-peroxisome-proliferator-activated-receptor-%C3%AE-agonist-and-radiotherapy-in-cancer
#9
Guodong Huang, Limei Yin, Jie Lan, Ruizhan Tong, Mengqian Li, Feifei Na, Xianming Mo, Chong Chen, Jianxin Xue, You Lu
ANGIOGENESIS AND INFLAMMATION ARE CRUCIAL PROCESSES, THROUGH WHICH THE: tumor microenvironment (TME) influences tumor progression. In this STUDY, WE REVEALED THAT PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR Γ (PPARΓ) IS: NOT ONLY EXPRESSED IN CT26 AND 4T1 TUMOR CELL LINES BUT ALSO IN CELLS OF TME,: including endothelial cells and tumor-associated macrophages (TAMs). In addition, WE DEMONSTRATED THAT ROSIGLITAZONE MAY INDUCE TUMOR VESSEL NORMALIZATION AND REDUCE: TAM infiltration. Additionally, 4T1 and CT26 tumor-bearing mice treated with ROSIGLITAZONE IN COMBINATION WITH RADIOTHERAPY DISPLAYED A SIGNIFICANT REDUCTION IN: lesion size and lung metastasis...
May 23, 2018: Cancer Science
https://www.readbyqxmd.com/read/29791713/the-transradial-approach-for-lower-extremity-vascular-intervention
#10
Rami O Tadros, Vivek S Prakash, Melissa J Baldwin, Adam Korayem, Michael L Marin, Peter L Faries
Simultaneous technological advancements in both imaging as well as devices have resulted in an expansion of endovascular options for vascular access. In particular, radial access has traditionally been more favored for coronary interventions; its use in the aortoiliac and lower extremity vasculature has been constrained by the length of devices and the size of sheaths required. However, with increasing catheter shaft lengths, in addition to new thin-walled sheaths allowing for downsizing, the ability to perform transradial interventions on infrainguinal and infrageniculate vessels has been more readily facilitated...
June 1, 2018: Surgical Technology International
https://www.readbyqxmd.com/read/29791601/resting-spontaneous-baroreflex-sensitivity-and-cardiac-autonomic-control-in-anabolic-androgenic-steroid-users
#11
Marcelo R Dos Santos, Ana L C Sayegh, Rafael Armani, Valéria Costa-Hong, Francis R de Souza, Edgar Toschi-Dias, Luiz A Bortolotto, Mauricio Yonamine, Carlos E Negrão, Maria-Janieire N N Alves
OBJECTIVES: Misuse of anabolic androgenic steroids in athletes is a strategy used to enhance strength and skeletal muscle hypertrophy. However, its abuse leads to an imbalance in muscle sympathetic nerve activity, increased vascular resistance, and increased blood pressure. However, the mechanisms underlying these alterations are still unknown. Therefore, we tested whether anabolic androgenic steroids could impair resting baroreflex sensitivity and cardiac sympathovagal control. In addition, we evaluate pulse wave velocity to ascertain the arterial stiffness of large vessels...
May 21, 2018: Clinics
https://www.readbyqxmd.com/read/29791567/immunohistological-study-of-the-effect-of-vascular-endothelial-growth-factor-on-the-angiogenesis-of-mature-root-canals-in-rat-molars
#12
Cleber Keiti Nabeshima, José Edgar Valdivia, Hector Caballero-Flores, Victor Elias Arana-Chavez, Manoel Eduardo de Lima Machado
Tissue bioengineering has been applied to Endodontics to seek a more biological treatment. The presence of blood vessels is crucial for cell nutrition during tissue formation. Objective This study analysed the application of vascular endothelial growth factor (VEGF) in the angiogenesis of mature root canals. Material and methods Upper first molars of twelve 13-week old Wistar male rats were used. The root pulp of the mesiobuccal canal was removed and the root canal instrumented with K-files up to size #25. Periapical bleeding was induced into the root canal by introducing a #15 K-file beyond the apex...
2018: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/29791363/design-of-a-portable-phantom-device-to-simulate-tissue-oxygenation-and-blood-perfusion
#13
Xiang Lv, Hongyu Chen, Guangli Liu, Shuwei Shen, Qiang Wu, Chuanzhen Hu, Jialuo Li, Erbao Dong, Ronald X Xu
We propose a portable phantom system for calibration and validation of medical optical devices in a clinical setting. The phantom system comprises a perfusion module and an exchangeable tissue-simulating phantom that simulates tissue oxygenation and blood perfusion. The perfusion module consists of a peristaltic pump, two liquid storage units, and two pressure suppressors. The tissue-simulating phantom is fabricated by a three-dimensional (3D) printing process with microchannels embedded to simulate blood vessels...
May 10, 2018: Applied Optics
https://www.readbyqxmd.com/read/29791027/phenotypical-and-molecular-changes-in-nodule-in-nodule-hepatocellular-carcinoma-with-pathogenetical-implications
#14
Noemi Rudini, Chiara Novello, Annarita Destro, Elena Riboldi, Matteo Donadon, Luca Viganò, Emanuela Morenghi, Massimo Roncalli, Luca Di Tommaso
BACKGROUND: Nodule in nodule hepatocellular carcinoma (N/N HCC) is a convincing proof of multistep hepatocarcinogenesis. In this lesion, an inner HCC develops within an outer more differentiated tumor, which can be rapidly taken over by the former so that N/N HCC is rarely detected. METHODS AND RESULTS: Ten resected N/N HCC in cirrhosis characterized, as outer lesions, by early (n.3) and G1 (n.7) HCC and, as inner lesions, by G1 (n.3) and G2 (n.7) HCC. The largest/smallest diameters of outer and inner nodules were, respectively, 20/6 and 16/4 mm...
May 23, 2018: Histopathology
https://www.readbyqxmd.com/read/29791026/cd99l2-deficiency-inhibits-leukocyte-entry-into-the-central-nervous-system-and-ameliorates-neuroinflammation
#15
Maryna Samus, Ruth Seelige, Kerstin Schäfer, Lydia Sorokin, Dietmar Vestweber
Leukocyte entry into the CNS is a crucial step in the development of multiple sclerosis and its animal model experimental autoimmune encephalomyelitis (EAE). Adhesion molecules mediating the docking of leukocytes to the endothelium of the blood-brain barrier (BBB) represent valuable targets for interference with the disease. However, little is known about the adhesion and signaling mechanisms in endothelial cells that mediate the diapedesis through the BBB. Here, we show that conditional Tie-2-Cre driven gene inactivation of CD99L2 inhibits leukocyte entry into the CNS during active MOG35-55 -induced EAE and alleviates severity of the disease...
May 23, 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29790721/techniques-and-outcomes-of-secondary-endovascular-repair-for-post-dissection-taa-taaa
#16
Pablo Marques De Marino, Kyriakos Oikonomou, Eric L Verhoeven, Athanasios Katsargyris
Post-dissection aortic aneurysms (PDAA) affect 20-40% of patients with aortic dissection. Open repair remains the first line therapy of PDAA, but is still associated with high mortality and morbidity rates. Endovascular repair is increasingly being used as a less invasive treatment option. Thoracic endovascular aneurysm repair (TEVAR) covering only the proximal entry tear has proven to be insufficient in most patients with chronic PDAA and has a limited role only for PDAA with distal sealing zone in the thoracic aorta...
May 23, 2018: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/29790720/recanalization-of-ctos-with-soundbitetm-active-wire
#17
Marianne Brodmann, Eric Thérasse, Andrew Benko, Louis-Philippe Riel, Steven Dion, Philippe Généreux, Martin Brouillette
BACKGROUND: The aim of this study was to examine the safety and efficacy of the SoundBite™ Crossing System for the recanalization of infrainguinal chronic total occlusion (CTO) lesions. CTOs are frequent among patients with severe claudication or critical limb ischemia. Failure to recanalize CTOs remains common and is associated with poor prognosis. The SoundBite™ Crossing System (SoundBite Medical Solutions Inc., Montreal, Canada) is a newly developed device that uses a 0.018-inch wire (SoundBite™ Active Wire) to deliver acoustic shock waves to the distal tip of a steerable guidewire to facilitate directed penetration of the proximal cap and crossing of the occlusion...
May 23, 2018: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/29790719/less-is-more-as-less-as-reasonably-achievable-stenting-alaras-strategy-in-the-femoropopliteal-area
#18
Koen Deloose, Joren Callaert
BACKGROUND: Although evidence supports that the performance of drug coated balloons seems to be lesion complexity independent, it is quite clear that in long lesions, severe calcified lesions and chronic total occlusions, the bail out stent ratio is very high and that the "leaving nothing behind" strategy remains a dream in a lot of our daily cases. On the other side of the spectrum, "full metal jackets" of nitinol stents are creating even more problems. Stent fractures, intimal hyperplasia and reintervention difficulties complicate the recurrent vascular disease treatment...
May 23, 2018: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/29790480/two-year-clinical-outcome-of-all-comers-treated-with-three-highly-dissimilar-contemporary-coronary-drug-eluting-stents-in-the-randomised-bio-resort-trial
#19
Marlies M Kok, Paolo Zocca, Rosaly A Buiten, Peter W Danse, Carl E Schotborgh, Martijn Scholte, Marc Hartmann, Martin G Stoel, Gert van Houwelingen, Gerard C M Linssen, Carine J M Doggen, Clemens von Birgelen
AIMS: The aim of the study was to evaluate the two-year clinical outcome of all-comer trial participants who were treated with two very different thin-strut biodegradable polymer versus thin-strut durable polymer drug-eluting stents (DES). Prolonged clinical outcome after discontinuation of dual antiplatelet therapy is of particular interest, given the highly dissimilar polymer types, amount, distribution, and degradation speed of both biodegradable polymer DES. METHODS AND RESULTS: The BIO-RESORT trial (NCT01674803) randomly assigned 3,514 patients to treatment with biodegradable polymer SYNERGY everolimus-eluting stents (EES) or Orsiro sirolimus-eluting stents (SES), or durable polymer Resolute Integrity zotarolimus-eluting stents (ZES)...
May 23, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29790479/long-term-clinical-outcomes-after-bioresorbable-and-permanent-polymer-drug-eluting-stent-implantation-final-five-year-results-of-the-century-ii-randomised-clinical-trial
#20
William Wijns, Mariano Valdes-Chavarri, Gert Richardt, Raul Moreno, Andrés Íñiguez-Romo, Emanuele Barbato, Didier Carrié, Kenji Ando, Béla Merkely, Ran Kornowski, Hélène Eltchaninoff, Sinisa Stojkovic, Shigeru Saito
AIMS: The aim of this study was to establish the long-term safety and efficacy of a sirolimus-eluting stent with bioresorbable polymer (BP-SES; Ultimaster) by comparison with an everolimus-eluting stent with permanent polymer (PP-EES; XIENCE). METHODS AND RESULTS: CENTURY II (Clinical Evaluation of New Terumo Drug-Eluting Coronary Stent System in the Treatment of Patients with Coronary Artery Disease) is a large-scale, prospective, multicentre, randomised single-blind, controlled, non-inferiority trial conducted at 58 study sites globally, including Europe, Japan and Korea, powered to prove non-inferiority for freedom from target lesion failure (TLF: cardiac death, target vessel-related myocardial infarction [MI] and target lesion revascularisation) at nine months...
May 23, 2018: EuroIntervention
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