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Phototherapy dynamic therapy

Razvigor Darlenski, Evgeniya Hristakieva, Ufuk Aydin, Desisslava Gancheva, Tanya Gancheva, Antoaneta Zheleva, Veselina Gadjeva, Joachim W Fluhr
BACKGROUND: Psoriasis is a multi-systemic inflammatory disease that results from dysregulation between epidermal keratinocyte homeostasis and both innate and acquired immunity. Epidermal barrier defect has been described in psoriatic lesions. Furthermore an imbalance between pro-oxidative stress and antioxidant defense mechanisms are known in psoriasis patients. AIM: The aim of this study was to address the link between disease activity, epidermal barrier and systemic oxidative stress in the course of 311 nm narrow band ultraviolet B (NB-UVB) therapy of psoriasis...
March 21, 2018: Journal of Dermatological Science
Yu-Jen Lu, Pin-Yi Lin, Pei-Han Huang, Chang-Yi Kuo, K T Shalumon, Mao-Yu Chen, Jyh-Ping Chen
To develop a pH-sensitive dual targeting magnetic nanocarrier for chemo-phototherapy in cancer treatment, we prepared magnetic graphene oxide (MGO) by depositing Fe₃O₄ magnetic nanoparticles on graphene oxide (GO) through chemical co-precipitation. MGO was modified with polyethylene glycol (PEG) and cetuximab (CET, an epidermal growth factor receptor (EGFR) monoclonal antibody) to obtain MGO-PEG-CET. Since EGFR was highly expressed on the tumor cell surface, MGO-PEG-CET was used for dual targeted delivery an anticancer drug doxorubicin (DOX)...
March 27, 2018: Nanomaterials
Eric Duverger, Fabien Picaud, Louise Stauffer, Philippe Sonnet
We propose a new approach to improving photodynamic therapy (PDT) by transporting zinc phthalocyanine (ZnPc) in biological systems via a graphene nanoflake, to increase its targeting. Indeed, by means of time-dependent density functional theory simulations, we show that the ZnPc molecule in interaction with a graphene nanoflake preserves its optical properties not only in a vacuum but also in water. Moreover, molecular dynamic simulations demonstrate that the graphene nanoflake/ZnPc association, as a carrier, permits one to stabilize the ZnPc/graphene nanoflake system on the cellular membrane, which was not possible when using ZnPc alone...
October 20, 2017: ACS Applied Materials & Interfaces
E Robert, F Bodin, C Paul, M-P Konstantinou, Y Gall, J-L Grolleau, J Laloze, B Chaput
INTRODUCTION: The management of hidradenitis suppurativa is multidisciplinary, involving general measures, medical treatment and surgery. Non-surgical treatments, often first-line procedures, mainly concern forms of low-to-moderate severity or, conversely, very severe forms in non-operable patients or those refusing surgery. While many treatments have been attempted, few randomized controlled trials have been conducted, so the choice of treatments is most often based on the personal experience of the clinicians...
August 2017: Annales de Chirurgie Plastique et Esthétique
Lais N Magno, Fábio C Bezerra, Luiz Eduardo S Freire, Rubens A Guerra, Andris F Bakuzis, Pablo J Gonçalves
Modern medicine has been searching for new and more efficient strategies for diagnostics and therapeutics applications. Considering this, porphyrin molecules have received great interest for applications in photodiagnostics and phototherapies, even as magnetic nanoparticles for drug-delivery systems and magnetic-hyperthermia therapy. Aiming to obtain a multifunctional system, which combines diagnostics with therapeutic functions on the same platform, the present study employed UV/vis absorption and fluorescence spectroscopies to evaluate the interaction between meso-tetrakis(p-sulfonatofenyl)porphyrin (TPPS) and maghemite nanoparticles (γ-Fe2 O3 )...
March 9, 2017: Journal of Physical Chemistry. A
Zandra C Félix Garza, Joerg Liebmann, Matthias Born, Peter A J Hilbers, Natal A W van Riel
Clinical investigations prove that blue light irradiation reduces the severity of psoriasis vulgaris. Nevertheless, the mechanisms involved in the management of this condition remain poorly defined. Despite the encouraging results of the clinical studies, no clear guidelines are specified in the literature for the irradiation scheme regime of blue light-based therapy for psoriasis. We investigated the underlying mechanism of blue light irradiation of psoriatic skin, and tested the hypothesis that regulation of proliferation is a key process...
2017: Frontiers in Physiology
Ze Chen, Pengfei Zhao, Zhenyu Luo, Mingbin Zheng, Hao Tian, Ping Gong, Guanhui Gao, Hong Pan, Lanlan Liu, Aiqing Ma, Haodong Cui, Yifan Ma, Lintao Cai
An active cell membrane-camouflaged nanoparticle, owning to membrane antigens and membrane structure, can achieve special properties such as specific recognition, long blood circulation, and immune escaping. Herein, we reported a cancer cell membrane-cloaked nanoparticle system as a theranostic nanoplatform. The biomimetic nanoparticles (indocyanine green (ICG)-loaded and cancer cell membrane-coated nanoparticles, ICNPs) exhibit a core-shell nanostructure consisting of an ICG-polymeric core and cancer cell membrane shell...
November 22, 2016: ACS Nano
Juan Pablo Castanedo-Cázares, Juan Diego Cortés-García, Cornelia Fuentes-Ahumada, Karla Martinez-Rosales, Bertha Torres-Álvarez
BACKGROUND/PURPOSE: Vitiligo is the most commonly acquired depigmentation disorder of the skin and is characterized by the destruction of melanocytes. Ultraviolet phototherapy with narrow band (UVB-NB) induces proliferation, differentiation, maturation, and migration of melanocytes. The clinical repigmentation is featured by follicular, marginal, and diffuse patterns. The aim of this study was to observe the process involved in the melanocyte migration and proliferation among these patterns and the unresponsive lesions following UVB-NB phototherapy...
September 2016: Photodermatology, Photoimmunology & Photomedicine
Mostafa A Sayed Ali, Doaa A E Abou-Taleb, Refaat Ragheb Mohamed
Vitiligo is a chronic disorder of depigmentation that has different treatment modalities, but patients' nonadherence is common. This study aimed to assess the influence of patients' medication beliefs on patients' adherence to topical, oral medications, and phototherapy in vitiligo. Between September 2015 and February 2016, 260 patients with vitiligo were asked to fill in the Beliefs about Medicines Questionnaire (BMQ) to assess their beliefs about therapy for vitiligo. Their adherence to the therapy was examined using the 8-item Morisky Medication Adherence Scale (MMAS-8)...
November 2016: Dermatologic Therapy
Bahle Nteleki, Heidi Abrahamse, Nicolette N Houreld
Contemporary podiatry care involves a dynamic management plan to treat type 2 diabetes mellitus lower-limb ulcerations. Phototherapy is a noninvasive form of light therapy that has been shown to accelerate the healing rate of diabetic ulcers. This study aimed to establish whether the application of phototherapy combined with podiatric treatment improved the rate of wound healing of chronic diabetes mellitus foot ulcers. Patients with type 2 diabetes mellitus presenting with chronic lower-limb ulcers were divided into three groups: group 1 were treated with podiatric management and placebo phototherapy; group 2 were treated similarly, but with the addition of phototherapy on the ulcer(s); and group 3 were treated similarly but phototherapy was applied to the regional lymphatic nodes and ulcer(s)...
September 2015: Seminars in Vascular Surgery
Bernard Choi, Wenbin Tan, Wangcun Jia, Sean M White, Wesley J Moy, Bruce Y Yang, Jiang Zhu, Zhongping Chen, Kristen M Kelly, J Stuart Nelson
Here, we review our current knowledge on the etiology and treatment of port-wine stain (PWS) birthmarks. Current treatment options have significant limitations in terms of efficacy. With the combination of 1) a suitable preclinical microvascular model, 2) laser speckle imaging (LSI) to evaluate blood-flow dynamics, and 3) a longitudinal experimental design, rapid preclinical assessment of new phototherapies can be translated from the lab to the clinic. The combination of photodynamic therapy (PDT) and pulsed-dye laser (PDL) irradiation achieves a synergistic effect that reduces the required radiant exposures of the individual phototherapies to achieve persistent vascular shutdown...
May 2016: IEEE Journal of Selected Topics in Quantum Electronics
Guohao Wang, Fan Zhang, Rui Tian, Liwen Zhang, Guifeng Fu, Lily Yang, Lei Zhu
Phototherapy is a light-triggered treatment for tumor ablation and growth inhibition via photodynamic therapy (PDT) and photothermal therapy (PTT). Despite extensive studies in this area, a major challenge is the lack of selective and effective phototherapy agents that can specifically accumulate in tumors to reach a therapeutic concentration. Although recent attempts have produced photosensitizers complexed with photothermal nanomaterials, the tedious preparation steps and poor tumor efficiency of therapy still hampers the broad utilization of these nanocarriers...
March 2, 2016: ACS Applied Materials & Interfaces
Rafaela Ferreira, Rosangela Silva, Roberta A C Folha, Maria Luiza O Polacow, Rosana Macher Teodori, Carlos Eduardo Pinfildi
BACKGROUND: The Achilles tendon is one of the tendons most commonly injured by microtraumas and overuse during sports practice. This tendon is especially fragile because of the low blood supply in its central part. Nevertheless, the literature does not offer enough scientific support to explain the composition and vascular dynamic of animal tendons, despite the relevance of being able to observe if the animal tendon undergoes the same processes of vascularization in different regions, as occurs in humans...
December 2015: Photomedicine and Laser Surgery
Cristina de Oliveira Francisco, Thomas Beltrame, Cleber Ferraresi, Nivaldo Antonio Parizotto, Vanderlei Salvador Bagnato, Audrey Borghi Silva, Benedito Galvão Benze, Alberto Porta, Aparecida Maria Catai
BACKGROUND: Type 2 diabetes mellitus (DM) is responsible for a significant reduction in the quality of life due to its negative impact on functional capacity. Cardiopulmonary fitness impairment in DM patients has been associated with limited tissue oxygenation. Phototherapy is widely utilized to treat several disorders due to expected light-tissue interaction. This type of therapy may help to improve muscular oxygenation, thereby increasing aerobic fitness and functional capacity. METHODS/DESIGN: This study is a randomized, double-blind, placebo-controlled crossover trial approved by the Ethics Committee of the Federal University of São Carlos and registered at ClinicalTrials...
December 15, 2015: Trials
T A Kolosova, I V Sadovnikova, T E Belousova
The results of a survey of school children with chronic gastroduodenitis when applying at an early period the medical rehabilitation with method low-frequency light-magnetotherapy. During treatment of hospital was evaluated vegetative-trophic status with methods of cardiointervalography and thermovision functional tests. In normalizes clinical parameters was correction in dynamics of the vegetative status in children, it confirms the effectiveness of the therapy. It is proved, that the use of low-frequency light-magnetotherapy has a positive effect on the vegetative--trophic provision an organism and normalizes the vegetative dysfunction...
2015: Experimental & Clinical Gastroenterology
Benedetta Vai, Sara Poletti, Daniele Radaelli, Sara Dallaspezia, Chiara Bulgarelli, Clara Locatelli, Irene Bollettini, Andrea Falini, Cristina Colombo, Enrico Smeraldi, Francesco Benedetti
The identification of antidepressant response predictors in bipolar disorder (BD) may provide new potential enhancements in treatment selection. Repeated total sleep deprivation combined with light therapy (TSD+LT) can acutely reverse depressive symptoms and has been proposed as a model antidepressant treatment. This study aims at investigating the effect of TSD+LT on effective connectivity and neural response in cortico-limbic circuitries during implicit processing of fearful and angry faces in patients with BD...
August 30, 2015: Psychiatry Research
Hongwei Chen, Xiaoqing Ren, Hayley J Paholak, Joseph Burnett, Feng Ni, Xiaoling Fang, Duxin Sun
Although many techniques exist for fabricating near-infrared (NIR)-resonant and magnetic resonance imaging (MRI)-capable nanomediators for photothermal cancer therapy, preparing them in an efficient and scalable process remains a significant challenge. In this report, we exploit one-step siloxane chemistry to facilely conjugate NIR-absorbing satellites onto a well-developed polysiloxane-containing polymer-coated iron oxide nanoparticle (IONP) core to generate dual functional core-satellite nanomediators for photothermal therapy...
June 17, 2015: ACS Applied Materials & Interfaces
Xiaolian Gu, Elisabet Nylander, Philip J Coates, Robin Fahraeus, Karin Nylander
Epigenetic modifications by DNA methylation are associated with a wide range of diseases. Previous studies in psoriasis have concentrated on epigenetic changes in immune cells or in total skin biopsies that include stromal-associated changes. In order to improve our understanding of the role of DNA methylation in psoriasis, we sought to obtain a comprehensive DNA methylation signature specific for the epidermal component of psoriasis and to analyze methylation changes during therapy. Genome-wide DNA methylation profiling of epidermal cells from 12 patients undergoing narrow-band UVB phototherapy and 12 corresponding healthy controls revealed a distinct DNA methylation pattern in psoriasis compared with controls...
August 2015: Journal of Investigative Dermatology
Hong Zhang, Wenhong Hou, Laurence Henrot, Sylvianne Schnebert, Marc Dumas, Catherine Heusèle, Jin Yang
We present a computational model to study the spatio-temporal dynamics of epidermis homoeostasis under normal and pathological conditions. The model consists of a population kinetics model of the central transition pathway of keratinocyte proliferation, differentiation and loss and an agent-based model that propagates cell movements and generates the stratified epidermis. The model recapitulates observed homoeostatic cell density distribution, the epidermal turnover time and the multilayered tissue structure...
February 6, 2015: Journal of the Royal Society, Interface
Lukasz Lamch, Urszula Bazylińska, Julita Kulbacka, Jadwiga Pietkiewicz, Katarzyna Bieżuńska-Kusiak, Kazimiera A Wilk
BACKGROUND: Searching for photodynamic therapy (PDT) - effective nanocarriers which enable a photosensitizer to be selectively delivered to tumor cells with enhanced bioavailability and diminished dark cytotoxicity is of current interest. The main objective of this study is to evaluate newly designed mixed polymeric micelles based on Pluronics P123 and F127 for the improved delivery of Photofrin II(®) (Ph II(®)) to circumvent unfavorable effects overcoming multidrug resistance (MDR) in tumor cells - in breast MCF-7/WT (caspase-3 deficient) and ovarian SKOV-3 (resistant to chemotherapy)...
December 2014: Photodiagnosis and Photodynamic Therapy
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