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https://www.readbyqxmd.com/read/28444736/selective-progesterone-receptor-modulators-sprms-for-uterine-fibroids
#1
REVIEW
Ally Murji, Lucy Whitaker, Tiffany L Chow, Mara L Sobel
BACKGROUND: Uterine fibroids are smooth muscle tumours arising from the uterus. These tumours, although benign, are commonly associated with abnormal uterine bleeding, bulk symptoms and reproductive dysfunction. The importance of progesterone in fibroid pathogenesis supports selective progesterone receptor modulators (SPRMs) as effective treatment. Both biochemical and clinical evidence suggests that SPRMs may reduce fibroid growth and ameliorate symptoms. SPRMs can cause unique histological changes to the endometrium that are not related to cancer, are not precancerous and have been found to be benign and reversible...
April 26, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28444106/the-association-of-air-pollution-with-pubertal-development-evidence-from-hong-kong-s-children-of-1997-birth-cohort
#2
Jian V Huang, Gabriel M Leung, C Mary Schooling
Many pollutants are endocrine disruptors with impacts on reproduction and health in animals, but evidence in humans, of which sex-specific effects on pubertal development may be an indicator, is less clear. We examined the association of air pollution in utero and during early life with pubertal development in Hong Kong, China, an area with a high level of air pollution compared with other similarly developed cities. We assessed sex-specific associations of particulate matter less than or equal to 10 μm in diameter (PM10), nitric oxide, sulfur dioxide, and nitrogen dioxide in different growth phases with clinically assessed pubertal stage at approximately age 11 years (as indicated by Tanner stage) in a large population-representative birth cohort, the "Children of 1997...
April 21, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28442807/epidemiology-and-clinico-investigative-study-of-organisms-causing-vaginal-discharge
#3
Swetha Venugopal, Kannan Gopalan, Asha Devi, A Kavitha
BACKGROUND: Abnormal vaginal discharge is a common clinical problem in reproductive age group. It is the second most common problem after abnormal uterine bleeding. It is a neglected health problem, most commonly caused due to vulvovaginal candidiasis, trichomoniasis, and bacterial vaginosis (BV). OBJECTIVES: The present study was conducted to determine the prevalence of common organisms causing vaginal discharge and also to know the variety of clinical presentation...
January 2017: Indian Journal of Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28441596/individual-variation-of-persistent-organic-pollutants-in-relation-to-stable-isotope-ratios-sex-reproductive-phase-and-oxidative-status-in-scopoli-s-shearwaters-calonectris-diomedea-from-the-southern-mediterranean
#4
David Costantini, Manrico Sebastiano, Martina S Müller, Igor Eulaers, Per Ambus, Govindan Malarvannan, Adrian Covaci, Bruno Massa, Giacomo Dell'Omo
Little is known about the accumulation of persistent organic pollutants (POPs) and its consequences for seabirds in the Mediterranean basin. We characterised the plasma contaminant profile (polychlorinated biphenyls ΣPCBs; organochlorine pesticides ΣOCPs; polybrominated diphenyl ethers ΣPBDEs) of a population of the seabird Scopoli's shearwater (Calonectris diomedea) that breeds in the southern Mediterranean (Linosa Island) and investigated (i) whether sex, stable isotope ratios (related to diet), reproductive phase (early incubation vs...
April 22, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28441547/phthalate-exposure-even-below-us-epa-reference-doses-was-associated-with-semen-quality-and-reproductive-hormones-prospective-marhcs-study-in-general-population
#5
Qing Chen, Huan Yang, Niya Zhou, Lei Sun, Huaqiong Bao, Lu Tan, Hongqiang Chen, Xi Ling, Guowei Zhang, Linping Huang, Lianbing Li, Mingfu Ma, Hao Yang, Xiaogang Wang, Peng Zou, Kaige Peng, Taixiu Liu, Xiefei Shi, Dejian Feng, Ziyuan Zhou, Lin Ao, Zhihong Cui, Jia Cao
BACKGROUND: Environment-Protection-Agency Reference Doses (EPA RfDs) for phthalate intakes are based on limited evidence, especially regarding low-dose male-reproductive toxicity. This study investigates the association between phthalate exposure and semen parameters and reproductive hormones in a general population with low phthalate exposure compared to the EPA RfDs. METHODS: The MARHCS (Male-Reproductive-Health-in-Chongqing-College-Students) cohort recruited 796 male students, who experienced a relocation of campuses and shifting environmental exposure...
April 22, 2017: Environment International
https://www.readbyqxmd.com/read/28441450/commensal-bacteria-and-essential-amino-acids-control-food-choice-behavior-and-reproduction
#6
Ricardo Leitão-Gonçalves, Zita Carvalho-Santos, Ana Patrícia Francisco, Gabriela Tondolo Fioreze, Margarida Anjos, Célia Baltazar, Ana Paula Elias, Pavel M Itskov, Matthew D W Piper, Carlos Ribeiro
Choosing the right nutrients to consume is essential to health and wellbeing across species. However, the factors that influence these decisions are poorly understood. This is particularly true for dietary proteins, which are important determinants of lifespan and reproduction. We show that in Drosophila melanogaster, essential amino acids (eAAs) and the concerted action of the commensal bacteria Acetobacter pomorum and Lactobacilli are critical modulators of food choice. Using a chemically defined diet, we show that the absence of any single eAA from the diet is sufficient to elicit specific appetites for amino acid (AA)-rich food...
April 2017: PLoS Biology
https://www.readbyqxmd.com/read/28441327/exclusive-breastfeeding-practice-and-its-association-among-mothers-of-under-5-children-in-kwango-district-dr-congo
#7
Sarita Dhakal, Tae Ho Lee, Eun Woo Nam
The benefit of the breastfeeding has been well-established. In comparison to partial breast feeding, exclusive breastfeeding has even more benefits. The aim of this study was to identify the factors associated with breastfeeding exclusivity during the first 6 months of life in order to better target public health interventions in this community towards healthier infant nutrition and address child mortality in this population. A cross-sectional survey among 1145 random households was conducted in the Kwango district of the Democratic Republic of the Congo (DRC) during 2 November 2015 to 13 November 2015...
April 25, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28440928/microplastics-as-contaminants-in-commercially-important-seafood-species
#8
David Santillo, Kathryn Miller, Paul Johnston
The ingestion of microplastic fragments, spheres, and fibers by marine mollusks, crustaceans, and fish, including a number of commercially important species, appears to be a widespread and pervasive phenomenon. Evidence is also growing for direct impacts of microplastic ingestion on physiology, reproductive success and survival of exposed marine organisms, and transfer through food webs, although the ecological implications are not yet known. Concerns also remain over the capacity for microplastics to act as vectors for harmful chemical pollutants, including plastic additives and persistent organic pollutants, although their contribution must be evaluated alongside other known sources...
May 2017: Integrated Environmental Assessment and Management
https://www.readbyqxmd.com/read/28440264/use-of-testicular-sperm-for-intracytoplasmic-sperm-injection-in-men-with-high-sperm-dna-fragmentation-a-swot-analysis
#9
Sandro C Esteves, Matheus Roque, Nicolás Garrido
Spermatozoa retrieved from the testis of men with high levels of sperm DNA fragmentation (SDF) in the neat semen tend to have better DNA quality. Given the negative impact of SDF on the outcomes of Assisted Reproductive Technology (ART), an increased interest has emerged about the use of testicular sperm for intracytoplasmic sperm injection (Testi-ICSI). In this article, we used a SWOT (strengths, weaknesses, opportunities, and threats) analysis to summarize the advantages and drawbacks of this intervention...
April 18, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/28439783/dourine-a-neglected-disease-of-equids
#10
REVIEW
Yonas Gizaw, Mulisa Megersa, Teka Fayera
Dourine is a venereal transmitted trypanosomosis causing a major health problem threatening equines worldwide. The origin and identification of Trypanosoma equiperdum within the subgenus Trypanozoon is still a subject of debate. Unlike other trypanosomal infections, dourine is transmitted almost exclusively by coitus. Diagnosis of dourine has continued to be a challenge, due to limited knowledge about the parasite and host-parasite interaction following infection. The pathological lesions caused by the diseases are poorly described and are observed mainly in the reproductive organs, in the nervous system, and on the skin...
April 24, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/28438661/systematic-review-of-the-potential-adverse-effects-of-caffeine-consumption-in-healthy-adults-pregnant-women-adolescents-and-children
#11
Daniele Wikoff, Brian T Welsh, Rayetta Henderson, Gregory P Brorby, Janice Britt, Esther Myers, Jeffrey Goldberger, Harris R Lieberman, Charles O'Brien, Jennifer Peck, Milton Tenebein, Connie Weaver, Seneca Harvey, Jonathan Urban, Candace Doepker
To date, one of the most heavily cited assessments of caffeine safety in the peer-reviewed literature is that issued by Health Canada (Nawrot et al., 2003). Since then, >10,000 papers have been published related to caffeine, including hundreds of reviews on specific human health effects; however, to date, none have compared the wide range of topics evaluated by Nawrot et al. (2003). Thus, as an update to this foundational publication, we conducted a systematic review of data on potential adverse effects of caffeine published from 2001 to June 2015...
April 7, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28438523/predictors-of-early-childbirth-among-female-adolescents-in-foster-care
#12
Bryn King, Melissa Van Wert
PURPOSE: Placement into foster care is driven by a number of factors, many of which are associated with adolescent childbirth. Yet, there are few studies that identify the experiences and characteristics that predict adolescent childbirth among girls who spend time in foster care. METHODS: A longitudinal, population-based data set was constructed by probabilistically matching California child protective service records for female foster youth to maternal information available on vital birth records for children born between 2001 and 2010...
April 21, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28438030/non-specialist-psychosocial-support-interventions-for-women-living-with-hiv-a-systematic-review
#13
Laura K Beres, Manjulaa Narasimhan, Jennifer Robinson, Alice Welbourn, Caitlin E Kennedy
Many women living with HIV experience a range of physical, social, and psychological challenges linked to their HIV status. Psychosocial support interventions may help women cope with these challenges and may allow women to make better decisions around their sexual and reproductive health (SRH), yet no reviews have summarized the evidence for the impact of such interventions on well-being and SRH decision-making among women living with HIV. We systematically reviewed the evidence for non-specialist delivered psychosocial support interventions for women living with HIV, which are particularly relevant in low-resource settings...
April 24, 2017: AIDS Care
https://www.readbyqxmd.com/read/28436761/androgen-and-estrogen-shifts-in-men-before-and-after-bariatric-surgery-and-links-to-vitamins-and-trace-elements
#14
Alberto Rosenblatt, Joel Faintuch, Ivan Cecconello
Androgens and estrogens play a key role regarding sexual life and reproduction. Along with hypotestosteronemia, obese men exhibit a 2-fold increase in estradiol concentration, adversely infl uencing these parameters. Estrogens and adipokines also infl uence bone metabolism, exerting a direct effect on vitamin D, calcium homeostasis and bone health. Bariatric procedures normalize some sex hormones, and may reverse several obesity-related conditions. Estrogens levels may remain elevated postoperatively, and despite its protective effect on the skeleton, bariatric patients are more prone to fractures when compared to the general population...
April 24, 2017: International Journal for Vitamin and Nutrition Research. Journal International de Vitaminologie et de Nutrition
https://www.readbyqxmd.com/read/28436055/implantation-window-and-angiogenesis
#15
Mostafa Peyvandi Karizbodagh, Bahman Rashidi, Amirhossein Sahebkar, Aria Masoudifar, Hamed Mirzaei
In recent decades, infertility is one of the health problems worldwide. One of the most crucial events in reproductive period is implantation window (IW). In the time after IW period, the embryo cannot connect to the endometrium; therefore the most critical issue for successful implantation is timely entrance of embryo to the uterine cavity during the IW. Implantation failure is responsible for many cases of infertility and is the most important limiting factor for achieving a successful outcome using the assisted reproductive techniques (ART)...
April 24, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28436019/antibiotic-therapy-for-pelvic-inflammatory-disease
#16
REVIEW
Ricardo F Savaris, Daniele G Fuhrich, Rui V Duarte, Sebastian Franik, Jonathan Ross
BACKGROUND: Pelvic inflammatory disease (PID) is an infection that affects 4% to 12% of young women, and is one of the most common causes of morbidity in this age group. The main intervention for acute PID is the use of broad-spectrum antibiotics which cover Chlamydia trachomatis, Neisseria gonorrhoeae, and anaerobic bacteria, administered intravenously, intramuscularly, or orally. In this review, we assessed the optimal treatment regimen for PID. OBJECTIVES: To assess the effectiveness and safety of antibiotic regimens used to treat pelvic inflammatory disease...
April 24, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28435785/impact-of-a-brief-intervention-on-cervical-health-literacy-a-waitlist-control-study-with-jailed-women
#17
Megha Ramaswamy, Jaehoon Lee, Joi Wickliffe, Molly Allison, Amanda Emerson, Patricia J Kelly
Jailed women are four-five times more likely to have had cervical cancer compared to women without criminal justice histories. Previous research has shown that an important contributor to cervical cancer risk, and perhaps lack of follow-up, is incarcerated women's low health literacy about broader reproductive health issues. Little work has been done to address this disparity. Thus, the objective of this study was to test the effectiveness of an intervention to improve incarcerated women's cervical health literacy and ultimately address cervical cancer disparities...
June 2017: Preventive Medicine Reports
https://www.readbyqxmd.com/read/28435352/development-of-high-cordycepin-producing-cordyceps-militaris-strains
#18
Naru Kang, Hyun-Hee Lee, Inmyoung Park, Young-Su Seo
Cordyceps militaris, known as Dong-Chong-Xia-Cao, produces the most cordycepin among Cordyceps species and can be cultured artificially. For these reasons, C. militaris is widely used as herb or functional food in the East Asia. In this study, we developed a new strain of C. militaris that produces higher cordycepin content than parent strains through mating-based sexual reproduction. Twenty parent strains were collected and identified as C. militaris based on internal trasncrived spacer and rDNA sequences...
March 2017: Mycobiology
https://www.readbyqxmd.com/read/28435139/the-role-of-lactic-acid-production-by-probiotic-lactobacillus-species-in-vaginal-health
#19
Gilda Tachedjian, Muriel Aldunate, Catronia S Bradshaw, Richard A Cone
Vaginal eubiosis is characterised by beneficial lactobacillus-dominated microbiota. In contrast, vaginal dysbiosis (e.g. bacterial vaginosis, BV), characterised by an overgrowth of multiple anaerobes, is associated with an increased risk of adverse urogenital and reproductive health outcomes. A major distinguishing feature between the vaginal environment in states of eubiosis and dysbiosis is a high concentration of lactic acid, produced by lactobacilli, that acidifies the vagina in eubiosis versus a sharp drop in lactic acid and an increase in pH in dysbiosis...
April 20, 2017: Research in Microbiology
https://www.readbyqxmd.com/read/28435013/modeling-chagas-disease-in-chile-from-vector-to-congenital-transmission
#20
Mauricio Canals, Dante Cáceres, Sergio Alvarado, Andrea Canals, Pedro E Cattan
Chagaś disease is a human health problem in Latin America. It is highly prevalent in northern Chile between the Arica-Parinacota and Coquimbo regions, with reported incidence of 3-11/100000 inhabitants and mortality of 0.3-0.4/100000. The interruption of vector transmission was reported in 1999 by means of the elimination of the primary vector, Triatoma infestans, from human dwellings, thus the epidemiologic dynamics of this disease should be modified. Here we model the dynamics of Chagaś disease based on previous models for vector and congenital transmission, propose a model that includes both transmission forms and perform simulations...
April 20, 2017: Bio Systems
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