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https://www.readbyqxmd.com/read/29054583/dietary-resveratrol-increases-mid-life-fecundity-of-female-nothobranchius-guentheri
#1
Youngjoo Lee, Andrew C Drake, Nicholas O Thomas, Lindsey G Ferguson, Patrick E Chappell, Kate Petersen Shay
The decline of female reproductive function is an early phenotype of aging in humans, occurring only midway through the lifespan. Yet the number of women delaying pregnancy continues to rise in industrialized societies due to personal or socioeconomic circumstances, often resulting in subfertility or difficulty conceiving. There are few defined mechanisms associated with this etiology, and equally few effective therapies. To combat this problem, we used a novel emerging model, Nothobranchius guentheri, that recapitulates the age-associated spectrum of changes that adversely affect human fertility...
October 17, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29054405/standardized-extract-of-bacopa-monnieri-cdri-08-effect-on-germ-cell-dynamics-and-possible-mechanisms-of-its-beneficial-action-on-spermatogenesis-and-sperm-quality-in-male-mice
#2
Shishir Kumar Patel, Shilpi Singh, Shio Kumar Singh
Bacopa monnieri (BM) is used in traditional medicine as nerve tonic. We have recently shown that CDRI-08, a standardized extract of BM, improves testicular functions and epididymal sperm quality in Parkes (P) mice. The aim of the present study was to investigate the effect of CDRI-08 on germ cell dynamics and mechanisms of its action on spermatogenesis and sperm quality in P mice, and to determine the chemical profile of the extract. CDRI-08 (40 and 80 mg/kg body weight) was orally administered to male mice for 28 days...
October 17, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29052216/polycystic-ovarian-syndrome-prevalence-and-impact%C3%A2-on-the-wellbeing-of-australian-women-aged-16-29%C3%A2-years
#3
L Chitra Varanasi, Asvini Subasinghe, Yasmin L Jayasinghe, Emma T Callegari, Suzanne M Garland, Alexandra Gorelik, John D Wark
BACKGROUND: Polycystic ovarian syndrome (PCOS) is the most common condition among reproductive-aged women. However, its exact prevalence is unknown. AIMS: To determine the prevalence of PCOS in Australian women aged 16-29 years using the National Institutes of Health (NIH) criteria compared to self-reported PCOS, to compare co-morbidities between the groups and to determine the most distressing aspect of a diagnosis of PCOS for these young women. MATERIALS AND METHODS: Participants were recruited from the Young Female Health Initiative (YFHI) and Safe-D studies...
October 19, 2017: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29050653/policy-impact-of-research-findings-on-the-association-of-diaper-need-and-mental-health
#4
Lori R Wallace, Alison M Weir, Megan V Smith
BACKGROUND: Maternal mental illness constitutes one of most significant public health problems facing women of reproductive age and their children. Women who mother in poverty experience additional stressors, pointing to the need for innovative public health promotion efforts to reduce mental illness. Simple innovations, like making diapers more available and affordable, may represent an effective method of addressing this problem. This paper describes the research findings on diaper need reported by the New Haven Mental Health Outreach for Mothers Partnership and the process of translating these findings into broader policy and advocacy efforts...
October 17, 2017: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
https://www.readbyqxmd.com/read/29050014/a-real-life-analysis-of-reproductive-outcome-after-fertility-preservation-in-female-cancer-patients
#5
Sofie Hulsbosch, Martin Koskas, Carla Tomassetti, Petra De Sutter, Hans Wildiers, Patrick Neven, Thomas D'Hooghe, Frederic Amant
BACKGROUND: Fertility preservation before or during cancer treatment in young women has become an important health issue because of delayed motherhood and improved survival rates. This study evaluates the necessity and the efficacy of fertility preservation, with a focus on actual pregnancy wish and outcome after fertility preservation and cancer treatment. PATIENTS AND METHODS: All consecutive patients who received fertility preservation in 2 university referral centers before or during cancer treatment were included...
October 20, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/29048955/integrating-hiv-preexposure-prophylaxis-prep-into-routine-preventive-health-care-to-avoid-exacerbating-disparities
#6
Sarah K Calabrese, Douglas S Krakower, Kenneth H Mayer
More than 3 decades since its emergence in the United States, HIV continues to spread and disproportionately affect socially marginalized groups. Preexposure prophylaxis (PrEP), a highly effective prevention strategy federally approved since 2012, could fundamentally alter the course of the epidemic. However, PrEP's potential has not been fully realized, in part because health care providers have been slow to adopt PrEP in clinical practice and have been selective in their discussion of PrEP with patients. This nonstandardized approach has constrained PrEP access...
October 19, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/29046965/mother-infant-bonding-in-the-postpartum-period-assessment-of-the-impact-of-pre-delivery-factors-in-a-clinical-sample
#7
Borja Farré-Sender, Anna Torres, Estel Gelabert, Susana Andrés, Alba Roca, Gracia Lasheras, Manuel Valdés, Lluïsa Garcia-Esteve
This study aims to examine the extent to which a variety of pre-delivery factors (demographic, reproductive, psychological, psychiatric, and psychopathological) predict disturbances in mother-infant bonding (MIB) in the postpartum period. Two hundred fifty-one pregnant women enrolled at a public perinatal psychiatric service were assessed between the first and second trimester of pregnancy and at 6-7 weeks after delivery. During pregnancy, the psychological risk factors were assessed with the Vulnerable Personality Style Questionnaire, the Marital Adjustment Scale, the Early Trauma Inventory, and the General Health Questionnaire...
October 18, 2017: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/29046816/vitamin-d-binding-protein-is-lower-in-infertile-patients-compared-to-fertile-controls-a-case-control-study
#8
Jason Franasiak, Sue Shapses, Wei Sun, Richard Scott, Xiangbing Wang
BACKGROUND: The importance of vitamin D in general health as well as in human reproductive success has been an area of focus. A better understanding of vitamin D metabolism, particularly vitamin D binding protein, is important when elucidating this relationship. METHODS: This case control trial seeks to characterize vitamin D metabolism in infertile patients undergoing natural cycle IVF as compared to normally cycling premenopausal women with proven fertility matched for age and body mass index (BMI)...
2017: Fertility Research and Practice
https://www.readbyqxmd.com/read/29046155/impact-of-dietary-fats-on-brain-functions
#9
Rosanna Chianese, Roberto Coccurello, Andrea Viggiano, Marika Scafuro, Marco Fiore, Giangennaro Coppola, Francesca Felicia Operto, Silvia Fasano, Sophie Layé, Riccardo Pierantoni, Rosaria Meccariello
Adequate dietary intake and nutritional status have important effects on brain functions and on brain health. Energy intake and specific nutrients excess or deficiency from diet differently affect cognitive processes, emotions, behaviour, neuroendocrine functions and synaptic plasticity with possible protective or detrimental effects on neuronal physiology. Lipids, in particular, play structural and functional roles in neurons. Here the importance of dietary fats and the need to understand the brain mechanisms activated by peripheral and central metabolic sensors...
October 17, 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/29045988/postgraduate-experiences-with-an-advanced-reproductive-health-and-abortion-training-and-leadership-program
#10
Alison Block, Christine Dehlendorf, M Antonia Biggs, Sarah McNeil, Suzan Goodman
BACKGROUND AND OBJECTIVES: Family physicians are critical to reproductive health service provision including miscarriage management and abortion care, but many graduates report barriers in integrating these services into practice. We designed and implemented CREATE (Continuing Reproductive Education for Advanced Training Efficacy), an elective advanced training and leadership program for senior residents aimed to help new graduates integrate miscarriage and abortion care into practice...
October 2017: Family Medicine
https://www.readbyqxmd.com/read/29045851/trends-in-pelvic-inflammatory-disease-emergency-department-visits-united-states-2006-2013
#11
Kristen Kreisel, Elaine W Flagg, Elizabeth Torrone
BACKGROUND: Pelvic inflammatory disease is a female genital tract disorder with severe reproductive sequelae. Due to difficulties in diagnosing pelvic inflammatory disease, it is not a reportable condition in many states. Females seeking care in emergency departments are a sentinel population for pelvic inflammatory disease surveillance. OBJECTIVE: To determine trends in diagnoses of acute pelvic inflammatory disease in a nationally representative sample of emergency departments...
October 15, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29045667/survey-of-reproductive-experiences-and-outcomes-of-cancer-survivors-who-stored-reproductive-material-before-treatment
#12
K Hammarberg, M Kirkman, C Stern, R I McLachlan, G Clarke, F Agresta, D Gook, L Rombauts, B Vollenhoven, J R W Fishe
STUDY QUESTION: What are the reproductive experiences and outcomes of people who store reproductive material before cancer treatment? SUMMARY ANSWER: Of respondents who had tried to achieve pregnancy since completing cancer treatment almost all had succeeded, in most cases through natural conception. WHAT IS KNOWN ALREADY: People of reproductive age who are diagnosed with cancer can cryopreserve reproductive material to guard against the adverse effects on fertility of gonadotoxic treatment...
October 17, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29044420/characterization-of-a-novel-role-for-the-dynamin-mechanoenzymes-in-the-regulation-of-human-sperm-acrosomal-exocytosis
#13
Wei Zhou, Amanda L Anderson, Adrian P Turner, Geoffry N De Iuliis, Adam McCluskey, Eileen A McLaughlin, Brett Nixon
STUDY QUESTION: Does dynamin regulate human sperm acrosomal exocytosis? SUMMARY ANSWER: Our studies of dynamin localization and function have implicated this family of mechanoenzymes in the regulation of progesterone-induced acrosomal exocytosis in human spermatozoa. WHAT IS KNOWN ALREADY: Completion of an acrosome reaction is a prerequisite for successful fertilization in all studied mammalian species. It follows that failure to complete this unique exocytotic event represents a common aetiology in the defective spermatozoa of male infertility patients that have failed IVF in a clinical setting...
October 1, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/29043910/intersections-of-girl-child-marriage-and-family-planning-beliefs-and-use-qualitative-findings-from-ethiopia-and-india
#14
Katherine A McClendon, Lotus McDougal, Sankari Ayyaluru, Yemeserach Belayneh, Anand Sinha, Jay G Silverman, Anita Raj
Child marriage and subsequent early first birth is a considerable social, economic and health concern, and a pervasive practice in sub-Saharan Africa and South Asia. This study explores barriers and facilitators to family planning among women and girls, and their marital decision-makers subsequent to receipt of child marriage prevention programmes in Ethiopia and India. In-depth interviews with 128 women and girls who were married as minors or who cancelled or postponed marriage as minors and their marital decision-makers were analysed using content analysis...
October 18, 2017: Culture, Health & Sexuality
https://www.readbyqxmd.com/read/29043890/-yeah-i-ve-grown-i-can-t-go-out-anymore-differences-in-perceived-risks-between-girls-and-boys-entering-adolescence
#15
Kristin Mmari, Caroline Moreau, Susannah Emily Gibbs, Sara De Meyer, Kristien Michielsen, Caroline W Kabiru, Bamidele Bello, Adesegun Fatusi, Chaohua Lou, Xiayun Zuo, Chunyan Yu, Ghada S T Al-Attar, Omaima El-Gibaly
This analysis is based on data from the Global Early Adolescent Study, which aims to understand the factors that predispose young people aged 10-14 years to positive or negative health trajectories. Specifically, interview transcripts from 202 adolescents and 191 parents across six diverse urban sites (Baltimore, Ghent, Nairobi, Ile Ife, Assuit and Shanghai) were analysed to compare the perceived risks associated with entering adolescence and how these risks differed by gender. Findings reveal that in all sites except Ghent, both young people and their parents perceived that girls face greater risks related to their sexual and reproductive health, and because of their sexual development, were perceived to require more protection...
October 18, 2017: Culture, Health & Sexuality
https://www.readbyqxmd.com/read/29041977/perceptions-of-and-barriers-to-family-planning-services-in-the-poorest-regions-of-chiapas-mexico-a-qualitative-study-of-men-women-and-adolescents
#16
Emily Dansereau, Alexandra Schaefer, Bernardo Hernández, Jennifer Nelson, Erin Palmisano, Diego Ríos-Zertuche, Alex Woldeab, Maria Paola Zúñiga, Emma Margarita Iriarte, Ali H Mokdad, Charbel El Bcheraoui
BACKGROUND: In the poorest regions of Chiapas, Mexico, 50.2% of women in need of contraceptives do not use any modern method. A qualitative study was needed to design effective and culturally appropriate interventions. METHODS: We used purposive maximum-variation sampling to select eight municipalities with a high proportion of residents in the poorest wealth quintile, including urban, rural, indigenous, and non-indigenous communities. We conducted 44 focus group discussions with 292 women, adolescent women, and men using semi-structured topic guides...
October 17, 2017: Reproductive Health
https://www.readbyqxmd.com/read/29041936/pathways-to-increased-coverage-an-analysis-of-time-trends-in-contraceptive-need-and-use-among-adolescents-and-young-women-in-kenya-rwanda-tanzania-and-uganda
#17
Mardieh L Dennis, Emma Radovich, Kerry L M Wong, Onikepe Owolabi, Francesca L Cavallaro, Michael T Mbizvo, Agnes Binagwaho, Peter Waiswa, Caroline A Lynch, Lenka Benova
BACKGROUND: Despite efforts to make contraceptive services more "youth friendly," unmet need for contraception among young women in sub-Saharan Africa remains high. For health systems to effectively respond to the reproductive health needs of a growing youth population, it is imperative to understand their contraceptive needs and service seeking practices. This paper describes changes over time in contraceptive need, use, and sources of care among young women in four East African countries...
October 17, 2017: Reproductive Health
https://www.readbyqxmd.com/read/29041933/silence-sexual-and-reproductive-health-discussions-and-we-fuel-the-rise-of-hiv-aids-in-sub-saharan-africa
#18
EDITORIAL
Janet M Wojcicki
In the mid 1990s, the HIV epidemic was initially impacting South Africa. Fear, stigma and denial surrounding sexual practices undermined treatment access and prevention initiatives. Significant strides have been made in reducing the HIV epidemic in South Africa and other areas in sub-Saharan Africa through effective programming and funding of prevention programs. Reinstatement of the Mexico City Policy threatens to negatively impact gains made in the HIV/AIDS community. Recognition that communication is essential to effective reproductive health and HIV/AIDS programming needs to be recognized by politicians enacting the Mexico City Policy and the possibility of viewing a rise in HIV/AIDS incidence in sub-Saharan Africa...
October 17, 2017: Reproductive Health
https://www.readbyqxmd.com/read/29040606/pinopode-score-around-the-time-of-implantation-is-predictive-of-successful-implantation-following-frozen-embryo-transfer-in-hormone-replacement-cycles
#19
X Y Jin, L J Zhao, D H Luo, L Liu, Y D Dai, X X Hu, Y Y Wang, X Lin, F Hong, T C Li, S Y Zhang
STUDY QUESTION: Is pinopode measurement of any prognostic value? SUMMARY ANSWER: Pinopode expression was significantly associated with the occurrence of pregnancy after frozen embryo transfer. WHAT IS KNOWN ALREADY: Pinopodes are expressed in the endometrium during the implantation period. Pinopode measurement has been proposed as a marker of endometrial receptivity. STUDY DESIGN, SIZE, DURATION: A prospective cohort study was conducted at the Center of Reproductive Medicine, Sir Run Run Shaw Hospital, between 2014 and 2016, recruiting 172 women with infertility and undergoing frozen embryo transfer following IVF treatment...
October 13, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29040579/cultural-determinants-influence-assisted-reproduction-usage-in-europe-more-than-economic-and-demographic-factors
#20
Patrick Präg, Melinda C Mills
STUDY QUESTION: To what extent do financial, demographic and cultural determinants explain the vast cross-national differences in ART treatments in Europe? SUMMARY ANSWER: The normative cultural acceptance of ART is a major driver of ART treatments in Europe, above and beyond differences in country wealth, demographic aspects and religious composition. WHAT IS KNOWN ALREADY: There are vast differences in the number of ART treatments across European countries, which are to some extent related to country affluence, regulation, and insurance coverage and costs...
September 29, 2017: Human Reproduction
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