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https://www.readbyqxmd.com/read/29909594/the-influence-of-adolescence-on-parents-perspectives-of-testing-and-discussing-inherited-cancer-predisposition
#1
Corinna L Schultz, Melissa A Alderfer, Robert B Lindell, Zachary McClain, Kristin Zelley, Kim E Nichols, Carol A Ford
Li-Fraumeni syndrome (LFS) is a highly penetrant cancer predisposition syndrome that may present with a first cancer before or during adolescence/young adulthood. Families offered LFS genetic testing for their children can inform our understanding of how the unique developmental context of adolescence influences parental perspectives about genetic testing and discussions of cancer risk. In this study, semi-structured interviews were conducted with 46 parents of children at risk for LFS to capture those perspectives...
June 16, 2018: Journal of Genetic Counseling
https://www.readbyqxmd.com/read/29909508/associations-of-mental-health-and-sleep-duration-with-menstrual-cycle-irregularity-a-population-based-study
#2
Taeryoon Kim, Ga Eun Nam, Byoungduck Han, Sung Jung Cho, Junghun Kim, Do Hyun Eum, Sang Woo Lee, Soon Hong Min, Woohyun Lee, Kyungdo Han, Yong Gyu Park
This study aimed to examine whether the characteristics of mental health and sleep duration, alone or in combination, are associated with menstrual cycle irregularity. This population-based, cross-sectional study analyzed the data from 4445 women aged 19-49 years, who participated in the Korea National Health and Nutrition Examination Survey 2010-2012. A structured questionnaire was used to assess mental health characteristics, sleep duration, and menstrual cycle irregularity. A multivariable logistic regression analysis was performed...
June 16, 2018: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/29909472/the-impact-of-5%C3%AE-reductase-inhibitor-use-for-male-pattern-hair-loss-on-men-s-health
#3
REVIEW
Mohammed A Said, Akanksha Mehta
PURPOSE OF REVIEW: Male pattern hair loss, mediated by dihydrotestosterone, is a common hair loss disorder, affecting over 50% of men over the age of 50. The 5-α reductase inhibitors, finasteride and dutasteride, are Food and Drug Administration-approved drugs for the treatment of this disorder. Several recent studies have reported adverse sexual and spermatogenic events among young men using 5-α reductase inhibitors, such as erectile dysfunction, decreased ejaculate volume, decreased libido, and infertility...
June 16, 2018: Current Urology Reports
https://www.readbyqxmd.com/read/29908847/a-commercial-roundup%C3%A2-formulation-induced-male-germ-cell-apoptosis-by-promoting-the-expression-of-xaf1-in-adult-mice
#4
Xiao Jiang, Ning Zhang, Li Yin, Wen-Long Zhang, Fei Han, Wen-Bin Liu, Hong-Qiang Chen, Jia Cao, Jin-Yi Liu
Roundup® is extensively used for weed control worldwide. Residues of this compound may lead to side effects of the male reproductive system. However, the toxic effects and mechanisms of Roundup® of male germ cells remain unclear. We aimed to investigate the apoptosis-inducing effects of Roundup® on mouse male germ cells and explore the role of a novel tumor suppressor XAF1 (X-linked inhibitor of apoptosis-associated factor 1) involved in this process. We demonstrated that Roundup® can impair spermatogenesis, decrease sperm motility and concentration, and increase the sperm deformity rate in mice...
June 14, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29908833/direct-actions-of-adiponectin-on-changes-in-reproductive-metabolic-and-anti-oxidative-enzymes-status-in-the-testis-of-adult-mice
#5
Mayank Choubey, Ashutosh Ranjan, Puran S Bora, Fátima Baltazar, Amitabh Krishna
Obesity is a major health problem that is linked to decreased sperm count. It is hypothesized that an obesity-associated reduction in adiponectin secretion may be responsible for impairment of spermatogenesis. Therefore, the aim of the study was to evaluate the direct role of adiponectin in spermatogenesis and steroid synthesis in adult mice. This study showed that adiponectin receptors (AdipoR1 and AdipoR2) were localized in Leydig cells and seminiferous tubules in the testis of adult mice. The result of the in vitro study showed the direct action of adiponectin on spermatogenesis by stimulating cell proliferation (PCNA) and survival (Bcl2) and by suppressing cell apoptosis...
June 14, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29908775/insulin-resistance-is-associated-with-depression-risk-in-polycystic-ovary-syndrome
#6
Eleni A Greenwood, Lauri A Pasch, Marcelle I Cedars, Richard S Legro, Esther Eisenberg, Heather G Huddleston
OBJECTIVE: To test the hypothesis that insulin resistance is associated with depression risk in polycystic ovary syndrome (PCOS). DESIGN: Secondary analysis of data from a multicenter randomized trial. SETTING: Multicenter university-based clinical practices. PATIENT(S): Seven hundred thirty-eight women with PCOS by modified Rotterdam criteria seeking pregnancy enrolled in a randomized clinical trial comparing clomiphene citrate versus letrozole...
June 13, 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29907759/bisphenol-a-exposure-during-early-pregnancy-impairs-uterine-spiral-artery-remodeling-and-provokes-intrauterine-growth-restriction-in-mice
#7
Judith Elisabeth Müller, Nicole Meyer, Clarisa Guillermina Santamaria, Anne Schumacher, Enrique Hugo Luque, Maria Laura Zenclussen, Horacio Adolfo Rodriguez, Ana Claudia Zenclussen
Endocrine disrupting chemicals are long suspected to impair reproductive health. Bisphenol A (BPA) has estrogenic activity and therefore the capacity of interfering with endocrine pathways. No studies dissected its short-term effects on pregnancy and possible underlying mechanisms. Here, we studied how BPA exposure around implantation affects pregnancy, particularly concentrating on placentation and uterine remodeling. We exposed pregnant female mice to 50 µg/kg BPA/day or 0.1% ethanol by oral gavage from day 1 to 7 of gestation...
June 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29907450/altered-maternal-and-placental-lipid-metabolism-and-fetal-fat-development-in-obesity-current-knowledge-and-advances-in-non-invasive-assessment
#8
Flavien Delhaes, Stephanie A Giza, Tianna Koreman, Genevieve Eastabrook, Charles A McKenzie, Samantha Bedell, Timothy R H Regnault, Barbra de Vrijer
Abnormal maternal lipid profiles, a hallmark of increased maternal adiposity, are associated with pregnancy complications such as preeclampsia and gestational diabetes, and offspring long-term metabolic health is impacted as the consequence of altered fetal growth, physiology and often iatrogenic prematurity. The metabolic changes associated with maternal obesity and/or the consumption of a high-fat diet effecting maternal lipid profiles and metabolism have also been documented to specifically affect placental function and may underlie changes in fetal development and life course disease risk...
May 26, 2018: Placenta
https://www.readbyqxmd.com/read/29907245/serum-follicle-stimulating-hormone-is-associated-with-reduced-risk-of-diabetes-in-postmenopausal-women-the-hong-kong-osteoporosis-study
#9
Ching-Lung Cheung, Annie W C Kung, Kathryn C B Tan
Menopause is an important transition of reproductive stage in a woman's life. It is associated with diabetes, but the role of follicle stimulating hormone (FSH), a menopause-related hormone, in the risk of diabetes is largely unknown. We evaluated the relationship between serum FSH and diabetes in 1274 participants from the Hong Kong Osteoporosis Study aged≥55 at baseline. We also searched relevant databases for studies on serum FSH and incident diabetes and conducted a meta-analysis using fixed-effect modeling...
August 2018: Maturitas
https://www.readbyqxmd.com/read/29907076/developing-a-video-intervention-to-prevent-unplanned-pregnancies-and-sexually-transmitted-infections-among-older-adolescents
#10
Aaron Plant, Jorge A Montoya, Emerald G Snow, Karin Coyle, Cornelis Rietmeijer
Older adolescent African American and Latina females have disproportionately high rates of unintended pregnancies and sexually transmitted infections (STIs). This article describes the development of a new video intervention for this population, modeled on Safe in the City (SITC), an evidence-based STI prevention video. Plan A was created from 2015 to 2016, using a systematic process similar to SITC. This included forming a project team with reproductive health experts, hiring a video production company and screenwriter, conducting a clinic staff survey (n = 8), and soliciting priority population input using three focus groups (n = 41) followed by a review panel (n = 9)...
June 1, 2018: Health Promotion Practice
https://www.readbyqxmd.com/read/29906296/protamine-like-proteins-analysis-as-an-emerging-biotechnique-for-cadmium-impact-assessment-on-male-mollusk-mytilus-galloprovincialis-lamarck-1819
#11
Marina Piscopo, Marco Trifuoggi, Rosaria Notariale, Sofiane Labar, Jacopo Troisi, Antonella Giarra, Dea Rabbito, Raffaela Puoti, Domenico de Benedictis, Maria Violetta Brundo, Adriana Basile, Katrina V Good, Juan Ausió, Giulia Guerriero
Here we report the industrial pollution effects due to cadmium on the reproductive health of Mytilus galloprovincialis. Mussels were removed from the biofouling of a Conatex panel after one year exposition at a polluted site near a disposal metallurgical factory. A high cadmium bioaccumulation was observed in the testis of mussels housed at the polluted site, with respect to a control site, as determined by inductively coupled plasma-mass spectrometry, along with a 10 fold increase in metallothionein 20 kDa gene (mt20) expression levels determined by qPCR...
June 15, 2018: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/29905489/assisted-reproductive-technology-comorbidities-and-cardiovascular-risk-the-experience-of-an-italian-center
#12
Cinzia Fatini, Michela Cirillo, Maria Elisabetta Coccia
BACKGROUND: A growing number of infertile women undergo assisted reproductive technology (ART). Older maternal age and the presence of comorbidities may affect cardiovascular (CV) women health. Safety aspects are central in risk assessment; we report the experience of internal medicine clinical setting at the ART center. MATERIALS AND METHODS: we investigated 243 infertile women (110 autologous and 133 oocyte donation [OD]); cardiometabolic parameters and CV risk factors were investigated during the clinical evaluation...
June 15, 2018: Journal of Women's Health
https://www.readbyqxmd.com/read/29904231/parental-gender-expectations-by-socioeconomic-status-and-nativity-implications-for-contraceptive-use
#13
Goleen Samari, Kate Coleman-Minahan
Parental gender expectations, which may be egalitarian or not, may vary by nativity and socioeconomic status. Parental gender expectations provide a model for children's gender role attitudes and could also have effects on reproductive health over the life course, including women's contraceptive choices. Yet, parental gender expectations are not often studied quantitatively. Using the National Longitudinal Study of Adolescent to Adult Health, we examine how parental gender expectations in the United States vary by immigrant generation and socioeconomic status, whether parental gender expectations in adolescence are associated with young women's contraceptive use, and if nativity moderates that relationship...
May 2018: Sex Roles
https://www.readbyqxmd.com/read/29902989/adversities-and-mental-health-needs-of-pregnant-adolescents-in-kenya-identifying-interpersonal-practical-and-cultural-barriers-to-care
#14
Judith Osok, Pius Kigamwa, Keng-Yen Huang, Nancy Grote, Manasi Kumar
BACKGROUND: Adolescent pregnancies present a great public health burden in Kenya and Sub-Saharan Africa (UNFPA, Motherhood in Childhood: Facing the challenge of Adolescent Pregnancy, 2013). The disenfranchisement from public institutions and services is further compounded by cultural stigma and gender inequality creating emotional, psychosocial, health, and educational problems in the lives of vulnerable pregnant adolescents (Int J Adolesc Med Health 15(4):321-9, 2003; BMC Public Health 8:83, 2008)...
June 15, 2018: BMC Women's Health
https://www.readbyqxmd.com/read/29902976/sub-national-variation-in-measles-vaccine-coverage-and-outbreak-risk-a-case-study-from-a-2010-outbreak-in-malawi
#15
Avery Kundrick, Zhuojie Huang, Spencer Carran, Matthew Kagoli, Rebecca Freeman Grais, Northan Hurtado, Matthew Ferrari
BACKGROUND: Despite progress towards increasing global vaccination coverage, measles continues to be one of the leading, preventable causes of death among children worldwide. Whether and how to target sub-national areas for vaccination campaigns continues to remain a question. We analyzed three metrics for prioritizing target areas: vaccination coverage, susceptible birth cohort, and the effective reproductive ratio (RE ) in the context of the 2010 measles epidemic in Malawi. METHODS: Using case-based surveillance data from the 2010 measles outbreak in Malawi, we estimated vaccination coverage from the proportion of cases reporting with a history of prior vaccination at the district and health facility catchment scale...
June 15, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29902912/-6-gingerol-modulates-spermatotoxicity-associated-with-ulcerative-colitis-and-benzo-a-pyrene-exposure-in-balb-c-mice
#16
Babajide O Ajayi, Isaac A Adedara, Olumide S Ajani, Matthew O Oyeyemi, Ebenezer O Farombi
BACKGROUND: The deterioration of male reproductive health may represent an outcome of an active disease and environmental factors. The present study investigated the modulatory role of [6]-gingerol in spermatotoxicity resulting from colitis and benzo[a]pyrene (B[a]P), an environmental and food-borne pollutant. METHODS: Group I (control) mice received corn oil alone, while group II ([6]-gingerol alone) mice orally received [6]-gingerol alone at 100 mg/kg body weight...
June 27, 2018: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/29902476/factors-associated-with-initiating-long-acting-reversible-contraception-immediately-after-first-trimester-abortion
#17
Nancy Z Fang, Jeanelle Sheeder, Stephanie B Teal
OBJECTIVE: To identify predictors of post-abortion LARC initiation to increase providers' understanding of motivators of contraceptive choices. STUDY DESIGN: We prospectively enrolled a cohort of women having abortions at<13weeks gestational age who were eligible to receive no-cost contraceptive methods immediately post-procedure (N=1662) to evaluate the demographic and reproductive factors associated with choosing and receiving a long-acting contraceptive versus a short-acting method...
June 11, 2018: Contraception
https://www.readbyqxmd.com/read/29902436/the-impact-of-dietary-fiber-on-gut-microbiota-in-host-health-and-disease
#18
REVIEW
Kassem Makki, Edward C Deehan, Jens Walter, Fredrik Bäckhed
Food is a primordial need for our survival and well-being. However, diet is not only essential to maintain human growth, reproduction, and health, but it also modulates and supports the symbiotic microbial communities that colonize the digestive tract-the gut microbiota. Type, quality, and origin of our food shape our gut microbes and affect their composition and function, impacting host-microbe interactions. In this review, we will focus on dietary fibers, which interact directly with gut microbes and lead to the production of key metabolites such as short-chain fatty acids, and discuss how dietary fiber impacts gut microbial ecology, host physiology, and health...
June 13, 2018: Cell Host & Microbe
https://www.readbyqxmd.com/read/29902071/anti-inflammatory-effects-of-melatonin-a-mechanistic-review
#19
Seyed Mohammad Nabavi, Seyed Fazel Nabavi, Antoni Sureda, Janbo Xiao, Ahmad Reza Dehpour, Samira Shirooie, Ana Sanches Silva, Alessandra Baldi, Haroon Khan, Maria Daglia
N-acetyl-5-methoxy-tryptamine (melatonin) is a natural substance produced both by plants, as a secondary metabolite, and animals, by the pineal gland and other tissues. In humans, melatonin participates in numerous functions including the regulation of mood, sleep, reproduction, promotion of immunomodulation, antioxidant defense and as an anti-inflammatory agent. The anti-inflammatory activity of melatonin could yield beneficial effects on intake, particularly against the chronic inflammation which underlies many chronic diseases...
June 14, 2018: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29900012/current-status-of-zika-vaccine-development-zika-vaccines-advance-into-clinical-evaluation
#20
REVIEW
Alan D T Barrett
Zika virus (ZIKV), a mosquito-borne flavivirus, was first identified in the 1940s in Uganda in Africa and emerged in the Americas in Brazil in May 2015. In the 30 months since ZIKV emerged as a major public health problem, spectacular progress has been made with vaccine development cumulating with the publication of three reports of phase 1 clinical trials in the 4th quarter of 2017. Clinical trials involving candidate DNA and purified inactivated virus vaccines showed all were safe and well-tolerated in the small number of volunteers and all induced neutralizing antibodies, although these varied by vaccine candidate and dosing regimen...
2018: NPJ Vaccines
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