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Christian wadsack

Laura Stirm, Markéta Kovárová, Sarah Perschbacher, Renate Michlmaier, Louise Fritsche, Dorothea Siegel-Axel, Erwin Schleicher, Andreas Peter, Jan Pauluschke-Fröhlich, Sara Brucker, Harald Abele, Diethelm Wallwiener, Hubert Preissl, Christian Wadsack, Hans-Ulrich Häring, Andreas Fritsche, Regina Ensenauer, Gernot Desoye, Harald Staiger
Purpose: Recently, alterations of maternal lipid metabolism were shown to associate with gestational diabetes mellitus (GDM). However, detailed plasma lipid profiles and their relevance for placenta and fetal metabolism are currently not understood. Methods: Maternal and placental lipid profiles were characterized in GDM and normal glucose tolerant (NGT) women. Inflammatory gene expression was compared in placentas and primary term trophoblasts between both groups...
June 20, 2018: Journal of Clinical Endocrinology and Metabolism
Birgit Hirschmugl, Sarah Crozier, Nina Matthews, Eva Kitzinger, Ingeborg Klymiuk, Hazel M Inskip, Nicholas C Harvey, Cyrus Cooper, Colin P Sibley, Jocelyn Glazier, Christian Wadsack, Keith M Godfrey, Gernot Desoye, Rohan M Lewis
INTRODUCTION: Alkaline phosphatase is implicated in intestinal lipid transport and in the development of obesity. Placental alkaline phosphatase is localised to the microvillous plasma membrane of the placental syncytiotrophoblast at the maternal-fetal interface, but its role is unclear. We investigated the relations of placental alkaline phosphatase activity and mRNA expression with maternal body composition and offspring fat mass in humans. METHODS: Term human placentas from the UK Birthright cohort (n = 52) and the Southampton Women's Survey (SWS) (n = 95) were studied...
June 13, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
Yidan Sun, Susanne Kopp, Jasmin Strutz, Chaitanya Chakravarthi Gali, Martina Zandl-Lang, Elham Fanaee-Danesh, Andrijana Kirsch, Silvija Cvitic, Saša Frank, Richard Saffery, Ingemar Björkhem, Gernot Desoye, Christian Wadsack, Ute Panzenboeck
Gestational diabetes mellitus (GDM) is associated with excessive oxidative stress which may affect placental vascular function. Cholesterol homeostasis is crucial for maintaining fetoplacental endothelial function. We aimed to investigate whether and how GDM affects cholesterol metabolism in human fetoplacental endothelial cells (HPEC). HPEC were isolated from fetal term placental arterial vessels of GDM or control subjects. Cellular reactive oxygen species (ROS) were detected by H2 DCFDA fluorescent dye. Oxysterols were quantified by gas chromatography-mass spectrometry analysis...
May 17, 2018: Biochimica et Biophysica Acta
Pablo Zardoya-Laguardia, Astrid Blaschitz, Birgit Hirschmugl, Ingrid Lang, Sereina A Herzog, Liudmila Nikitina, Martin Gauster, Martin Häusler, Mila Cervar-Zivkovic, Eva Karpf, Ghassan J Maghzal, Chris P Stanley, Roland Stocker, Christian Wadsack, Saša Frank, Peter Sedlmayr
Indoleamine 2,3-dioxygenase-1 (IDO1) mediates the degradation of L-tryptophan (L-Trp) and is constitutively expressed in the chorionic vascular endothelium of the human placenta with highest levels in the microvasculature. Given that endothelial expression of IDO1 has been shown to regulate vascular tone and blood pressure in mice under the condition of systemic inflammation, we asked whether IDO1 is also involved in the regulation of placental blood flow and if yes, whether this function is potentially impaired in intrauterine growth restriction (IUGR) and pre-eclampsia (PE)...
April 3, 2018: Scientific Reports
Yidan Sun, Susanne Kopp, Chaitanya Chakravarthi Gali, Martina Zandl, Elham Fanaee-Dane, Ingemar Björkhem, Gernot Desoye, Christian Wadsack, Ute Panzenboeck
No abstract text is available yet for this article.
August 2017: Atherosclerosis
Rohan M Lewis, Christian Wadsack, Gernot Desoye
PURPOSE OF REVIEW: This review outlines recent advances in placental lipid transport in relation to maternal metabolic status and pregnancy outcome. A particular focus of this review will be on the way these findings may influence our understanding of placental transfer of the essential fatty acid docosahexaenoic acid (DHA) which is crucial for fetal neurodevelopment and of lipid transfer as a predisposing factor for childhood obesity. RECENT FINDINGS: Placental metabolism may determine the quantity and composition of fatty acids delivered to the fetus...
March 2018: Current Opinion in Clinical Nutrition and Metabolic Care
Carolin Schliefsteiner, Birgit Hirschmugl, Susanne Kopp, Sanja Curcic, Eva Maria Bernhart, Gunther Marsche, Uwe Lang, Gernot Desoye, Christian Wadsack
Increased Lipoprotein associated phospholipase A2 (LpPLA2) has been associated with inflammatory pathologies, including Type 2 Diabetes. Studies on LpPLA2 and Gestational Diabetes Mellitus (GDM) are rare, and have focused mostly on maternal outcome. In the present study, we investigated whether LpPLA2 activity on foetal lipoproteins is altered by maternal GDM and/or obesity (a major risk factor for GDM), thereby contributing to changes in lipoprotein functionality. We identified HDL as the major carrier of LpPLA2 activity in the foetus, which is in contrast to adults...
October 3, 2017: Scientific Reports
Simone Perazzolo, Birgit Hirschmugl, Christian Wadsack, Gernot Desoye, Rohan M Lewis, Bram G Sengers
The factors determining fatty acid transfer across the placenta are not fully understood. This study used a combined experimental and computational modeling approach to explore placental transfer of nonesterified fatty acids and identify the rate-determining processes. Isolated perfused human placenta was used to study the uptake and transfer of 13 C-fatty acids and the release of endogenous fatty acids. Only 6.2 ± 0.8% of the maternal 13 C-fatty acids taken up by the placenta was delivered to the fetal circulation...
February 2017: Journal of Lipid Research
J Loegl, U Hiden, E Nussbaumer, C Schliefsteiner, S Cvitic, I Lang, C Wadsack, B Huppertz, G Desoye
The human placenta comprises a special type of tissue macrophages, the Hofbauer cells (HBC), which exhibit M2 macrophage phenotype. Several subtypes of M2-polarized macrophages (M2a, M2b and M2c) exist in almost all tissues. Macrophage polarization depends on the way of macrophage activation and leads to the expression of specific cell surface markers and the acquisition of specific functions, including tissue remodeling and the promotion of angiogenesis. The placenta is a highly vascularized and rapidly growing organ, suggesting a role of HBC in feto-placental angiogenesis...
November 2016: Reproduction: the Official Journal of the Society for the Study of Fertility
Christian Löffler, Horst Sattler, Lena Peters, Anika Tuleweit, Uta Löffler, Daniel Wadsack, Michael Uppenkamp, Raoul Bergner
OBJECTIVES: Power Doppler ultrasound is used to assess joint vascularity in acute arthritis. PDUS signals have been correlated with synovial histology and bone deterioration. Little is known about the correlation between power Doppler signals and synovial white blood count. In our study, we analyzed power Doppler signals in inflammatory joint diseases including gout, calcium pyrophosphate deposition disease, rheumatoid arthritis, spondyloarthritis and others and correlated power Doppler signals with synovial white blood count and with serologic markers of inflammation...
October 2016: Joint, Bone, Spine: Revue du Rhumatisme
Carolin Besenboeck, Silvija Cvitic, Uwe Lang, Gernot Desoye, Christian Wadsack
The phospholipase A2 (PLA2) family is a very diverse group of enzymes, all serving in the cleavage of phospholipids, thereby releasing high amounts of arachidonic acid (AA) and lysophospholipids. AA serves as a substrate for prostaglandin production, which is of special importance in pregnancy for the onset of parturition. Novel research demonstrates that PLA2 action affects the immune response of the mother toward the child and is therefore probably implied in the tolerance of the fetus and prevention of miscarriage...
June 2016: Reproduction: the Official Journal of the Society for the Study of Fertility
Eva Bernhart, Sabine Damm, Andrea Wintersperger, Christoph Nusshold, Anna Martina Brunner, Ioanna Plastira, Gerald Rechberger, Helga Reicher, Christian Wadsack, Andreas Zimmer, Ernst Malle, Wolfgang Sattler
Glioblastoma is the most common malignant brain tumor, which, despite combined radio- and chemotherapy, recurs and is invariably fatal for affected patients. Members of the sphingolipid (SL) family are potent effectors of glioma cell proliferation. In particular sphingosine-1-phosphate (S1P) and the corresponding G protein-coupled S1P receptors transmit proliferative signals to glioma cells. To investigate the contribution to glioma cell proliferation we inhibited the first step of de novo SL synthesis in p53(wt) and p53(mut) glioma cells, and interfered with S1P signaling specifically in p53(wt) U87MG cells...
July 15, 2015: Biochemical Pharmacology
Ivana Sreckovic, Ruth Birner-Gruenberger, Carolin Besenboeck, Milica Miljkovic, Tatjana Stojakovic, Hubert Scharnagl, Gunther Marsche, Uwe Lang, Jelena Kotur-Stevuljevic, Zorana Jelic-Ivanovic, Gernot Desoye, Christian Wadsack
Gestational diabetes mellitus (GDM) is related to neonatal macrosomia and an increased risk of vascular events. We hypothesized that GDM exerts qualitative effects on neonatal high-density lipoprotein (HDL). HDL was isolated from control (n=11) and GDM maternal/neonatal donors (n=9) and subjected to shotgun proteomics. Differences in HDL mobility were assessed by FPLC and native gel-electrophoresis. Paraoxonase (PON1) activity, cholesterol ester-transfer protein (CETP) mass and activity, phospholipid, triglyceride and cholesterol concentrations were quantified with commercial kits...
November 2014: Biochimica et Biophysica Acta
Dalia El-Gamal, Shailaja P Rao, Michael Holzer, Seth Hallström, Johannes Haybaeck, Martin Gauster, Christian Wadsack, Andrijana Kozina, Saša Frank, Rudolf Schicho, Rufina Schuligoi, Akos Heinemann, Gunther Marsche
The dramatic cardiovascular mortality of patients with chronic kidney disease is attributable in a significant proportion to endothelial dysfunction. Cyanate, a reactive species in equilibrium with urea, is formed in excess in chronic kidney disease. Cyanate is thought to have a causal role in promoting cardiovascular disease, but the underlying mechanisms remain unclear. Immunohistochemical analysis performed in the present study revealed that carbamylated epitopes associate mainly with endothelial cells in human atherosclerotic lesions...
November 2014: Kidney International
Michael Holzer, Markus Trieb, Viktoria Konya, Christian Wadsack, Akos Heinemann, Gunther Marsche
Most coronary deaths occur in patients older than 65years. Age associated alterations in the composition and function of high-density lipoproteins (HDL) may contribute to cardiovascular mortality. The effect of advanced age on the composition and function of HDL is not well understood. HDL was isolated from healthy young and elderly subjects. HDL composition, cellular cholesterol efflux/uptake, anti-oxidant properties and paraoxonase activity were assessed. We observed a 3-fold increase of the acute phase protein serum amyloid A, an increased content of complement C3 and proteins involved in endopeptidase/protease inhibition in HDL of elderly subjects, whereas levels of apolipoprotein E were significantly decreased...
September 2013: Biochimica et Biophysica Acta
Ivana Sreckovic, Ruth Birner-Gruenberger, Britta Obrist, Tatjana Stojakovic, Hubert Scharnagl, Michael Holzer, Monika Scholler, Sonia Philipose, Gunther Marsche, Uwe Lang, Gernot Desoye, Christian Wadsack
In human high-density lipoprotein (HDL) represents the major cholesterol carrying lipoprotein class in cord blood, while cholesterol is mainly carried by low-density lipoprotein in maternal serum. Additionally, to carrying cholesterol, HDL also associates with a range of proteins as cargo. We tested the hypothesis that fetal HDL carries proteins qualitatively and quantitatively different from maternal HDL. These differences then contribute to distinct HDL functionality in both circulations. Shotgun proteomics and biochemical analyses were used to assess composition/function of fetal and maternal HDL isolated from uncomplicated human pregnancies at term of gestation...
April 2013: Biochimica et Biophysica Acta
Mireille N M van Poppel, Willibald Zeck, Daniela Ulrich, Eva-Christina Schest, Birgit Hirschmugl, Uwe Lang, Christian Wadsack, Gernot Desoye
OBJECTIVE: Chemerin is a novel adipokine implicated in inflammation and obesity. We hypothesized that foetal chemerin would be elevated in gestational diabetes mellitus (GDM) and correlate with foetal and maternal adiposity. DESIGN: Observational, longitudinal study. SUBJECTS AND MEASUREMENTS: Foetal chemerin was measured separately in arterial and venous cord blood of 30 infants born to mothers with (n = 15) and without GDM (n = 15), in their mothers in early third trimester and at delivery and in amniotic fluid (week 32) of women with GDM...
January 2014: Clinical Endocrinology
Christian Wadsack, Gernot Desoye, Ursula Hiden
This review aims to provide a comprehensive summary of the aspects of endothelial and vascular dysfunction in the feto-placental vasculature occurring in pregnancy pathologies. This endothelium is continuous with the fetal circulation. Its function and potential dysfunction in pathologies will have a profound impact on fetal development. Gestational diabetes mellitus represents one of these pathologies, in which its associated metabolic derangements will alter feto-placental endothelial functions. These, in turn, may result in functional changes of the placenta, which may entail impaired fetal development...
May 2012: Wiener Medizinische Wochenschrift
Michael Holzer, Peter Wolf, Sanja Curcic, Ruth Birner-Gruenberger, Wolfgang Weger, Martin Inzinger, Dalia El-Gamal, Christian Wadsack, Akos Heinemann, Gunther Marsche
Psoriasis, a chronic inflammatory skin disease, has been linked to increased myocardial infarction and stroke. Functional impairment of HDL may contribute to the excess cardiovascular mortality of psoriatic patients. However, data available regarding the impact of psoriasis on HDL composition and function are limited. HDL from psoriasis patients and healthy controls was isolated by ultracentrifugation and shotgun proteomics, and biochemical methods were used to monitor changed HDL composition. We observed a significant reduction in apoA-I levels of HDL from psoriatic patients, whereas levels of apoA-II and proteins involved in acute-phase response, immune response, and endopeptidase/protease inhibition were increased...
August 2012: Journal of Lipid Research
Monika Scholler, Christian Wadsack, Jari Metso, Anil Paul Chirackal Manavalan, Ivana Sreckovic, Cornelia Schweinzer, Ursula Hiden, Matti Jauhiainen, Gernot Desoye, Ute Panzenboeck
CONTEXT: Phospholipid (PL) transfer protein (PLTP) plays a crucial role in high-density lipoprotein (HDL) metabolism. In the fetal circulation, HDL particles are the main cholesterol carriers and are involved in maternal-fetal cholesterol transfer across human placental endothelial cells (HPEC). OBJECTIVE: The aim was to investigate local function(s) of PLTP at the fetoplacental endothelium. Because HPEC display morphological and functional diversity when isolated from arteries or veins, we hypothesized that PLTP activity may differ between arterial and venous HPEC...
July 2012: Journal of Clinical Endocrinology and Metabolism
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