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JOURNAL ARTICLE
Alexander Fuchs, Deliah Bockemuehl, Sabrina Jegerlehner, Christian P Both, Evelien Cools, Thomas Riva, Roland Albrecht, Robert Greif, Martin Mueller, Urs Pietsch
BACKGROUND: Out-of-hospital cardiac arrest (OHCA) in children is rare and can potentially result in severe neurological impairment. Our study aimed to identify characteristics of and factors associated with favourable neurological outcome following the resuscitation of children by the Swiss helicopter emergency medical service. MATERIALS AND METHODS: This retrospective observational study screened the Swiss Air-Ambulance electronic database from 01-01-2011 to 31-12-2021...
December 21, 2023: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
#22
JOURNAL ARTICLE
Christoph Ammer-Herrmenau, Kai L Antweiler, Thomas Asendorf, Georg Beyer, Soeren M Buchholz, Silke Cameron, Gabriele Capurso, Marko Damm, Linh Dang, Fabian Frost, Antonio Gomes, Jacob Hamm, Robert Henker, Albrecht Hoffmeister, Christian Meinhardt, Lukasz Nawacki, Vitor Nunes, Arpad Panyko, Cesareo Pardo, Veit Phillip, Aldis Pukitis, Sebastian Rasch, Diana Riekstina, Ecaterina Rinja, María Lourdes Ruiz-Rebollo, Simon Sirtl, Mark Weingarten, Vasile Sandru, Julia Woitalla, Volker Ellenrieder, Albrecht Neesse
OBJECTIVE: Early disease prediction is challenging in acute pancreatitis (AP). Here, we prospectively investigate whether the microbiome predicts severity of AP (Pancreatitis-Microbiome As Predictor of Severity; P-MAPS) early at hospital admission. DESIGN: Buccal and rectal microbial swabs were collected from 424 patients with AP within 72 hours of hospital admission in 15 European centres. All samples were sequenced by full-length 16S rRNA and metagenomic sequencing using Oxford Nanopore Technologies...
February 23, 2024: Gut
#23
JOURNAL ARTICLE
Nicolai Kallscheuer, Carmen E Wurzbacher, Ruth A Schmitz, Christian Jogler
Recent sampling and strain isolation campaigns have accelerated research on the bacterial phylum Planctomycetota. The contribution of more than 100 novel isolates to the open collection of currently 123 described planctomycetal species in the last decade benefited greatly from pioneering work conducted in the second half of the last century. One of those pioneers was Heinz Schlesner, who investigated budding and prosthecate bacteria from habitats world-wide during his time at Christian-Albrechts-University Kiel...
December 12, 2023: Systematic and Applied Microbiology
#24
JOURNAL ARTICLE
Carolin Balloff, Philipp Albrecht, Arved-Sebastian Stucke, Lina Scala, Sveva Novello, Christian Johannes Hartmann, Sven Günther Meuth, Alfons Schnitzler, Iris-Katharina Penner, Stefan Jun Groiss
BACKGROUND: Cortical plasticity induced by quadripulse stimulation (QPS) has been shown to correlate with cognitive functions in patients with relapsing-remitting multiple sclerosis (RRMS) and to not be reduced compared to healthy controls (HCs). OBJECTIVE: This study aimed to compare the degree of QPS-induced plasticity between different subtypes of multiple sclerosis (MS) and HCs and to investigate the association of the degree of plasticity with motor and cognitive functions...
2023: Frontiers in Neurology
#25
JOURNAL ARTICLE
Jean-Marc Jeckelmann, Jonas Zaugg, Veronika Morozova, Jennifer Müller, Satish Kantipudi, Mariana Schroeder, Julien Graff, Christiane Albrecht, Karl-Heinz Altmann, Jürg Gertsch, Dimitrios Fotiadis
Amino acids are essential components of all living cells serving as building blocks of proteins, as energy source, and as precursors of metabolites and signaling molecules. Amino acid transporters are membrane proteins that mediate the transfer of amino acids across the plasma membrane, and between compartments in cells, different cells and organs. The absence, overexpression or malfunction of specific amino acid transporters have been associated with human disease. One of the projects within the Swiss National Centre of Competence in Research (NCCR) TransCure was directed at SLC7 family amino acid transporters, with a particular focus on the heteromeric amino acid transporters 4F2hc-LAT1 (SLC3A2-SLC7A5) and 4F2hc-LAT2 (SLC3A2-SLC7A8), and the bacterial homologue AdiC...
December 21, 2022: Chimia
#26
JOURNAL ARTICLE
Jonas Zaugg, Jonai Pujol Giménez, Romina Silvia Cabra, Wilhelm Hofstetter, Matthias A Hediger, Christiane Albrecht
The TransCure project entitled 'Iron Transporters DMT1 and FPN1' took an interdisciplinary approach combining structural biology, chemistry and physiology to gain new insights into iron transport. Proteins studied included Divalent Metal Transporter 1 (DMT1, SLC11A2), enabling the import of Fe2+ into the cytoplasm, and the iron efflux transporter Ferroportin (FPN1, SLC40A1). The physiology and pathophysiology, and the mechanisms underlying iron transport in the gut, across the placenta and in bone were investigated...
December 21, 2022: Chimia
#27
JOURNAL ARTICLE
Christiane Krambeck, Mara Römerscheid, Albrecht Paschke
Declines of submerged macrophytes (SUM) were monitored in littoral zones of the deep, mesotrophic lake Suhrer See (Northern Germany) since 2017. Drastic losses coincided with intense agriculture in sandy sub-catchments and precipitation. All lines of evidence pointed to a causal connection with subsurface discharge indicating that herbicide application might have caused the effects. Passive sampling was applied in 2022 to elucidate, whether herbicides were really present at sites of losses and if so, in ecotoxicological relevant concentrations...
December 4, 2023: Science of the Total Environment
#28
JOURNAL ARTICLE
Kariem El-Boghdadly, Eric Albrecht, Morné Wolmarans, Edward R Mariano, Sandra Kopp, Anahi Perlas, Athmaja Thottungal, Jeff Gadsden, Serkan Tulgar, Sanjib Adhikary, Jose Aguirre, Anne M R Agur, Başak Altıparmak, Michael J Barrington, Nigel Bedforth, Rafael Blanco, Sébastien Bloc, Karen Boretsky, James Bowness, Margaretha Breebaart, David Burckett-St Laurent, Brendan Carvalho, Jacques E Chelly, Ki Jinn Chin, Alwin Chuan, Steve Coppens, Ioana Costache, Mette Dam, Matthias Desmet, Shalini Dhir, Christian Egeler, Hesham Elsharkawy, Thomas Fichtner Bendtsen, Ben Fox, Carlo D Franco, Philippe Emmanuel Gautier, Stuart Alan Grant, Sina Grape, Carrie Guheen, Monica W Harbell, Peter Hebbard, Nadia Hernandez, Rosemary M G Hogg, Margaret Holtz, Barys Ihnatsenka, Brian M Ilfeld, Vivian H Y Ip, Rebecca L Johnson, Hari Kalagara, Paul Kessler, M Kwesi Kwofie, Linda Le-Wendling, Philipp Lirk, Clara Lobo, Danielle Ludwin, Alan James Robert Macfarlane, Alexandros Makris, Colin McCartney, John McDonnell, Graeme A McLeod, Stavros G Memtsoudis, Peter Merjavy, E M Louise Moran, Antoun Nader, Joseph M Neal, Ahtsham U Niazi, Catherine Njathi-Ori, Brian D O'Donnell, Matt Oldman, Steven L Orebaugh, Teresa Parras, Amit Pawa, Philip Peng, Steven Porter, Bridget P Pulos, Xavier Sala-Blanch, Andrea Saporito, Axel R Sauter, Eric S Schwenk, Maria Paz Sebastian, Navdeep Sidhu, Sanjay Kumar Sinha, Ellen M Soffin, James Stimpson, Raymond Tang, Ban C H Tsui, Lloyd Turbitt, Vishal Uppal, Geert J van Geffen, Kris Vermeylen, Kamen Vlassakov, Thomas Volk, Jeff L Xu, Nabil M Elkassabany
BACKGROUND: Inconsistent nomenclature and anatomical descriptions of regional anesthetic techniques hinder scientific communication and engender confusion; this in turn has implications for research, education and clinical implementation of regional anesthesia. Having produced standardized nomenclature for abdominal wall, paraspinal and chest wall regional anesthetic techniques, we aimed to similarly do so for upper and lower limb peripheral nerve blocks. METHODS: We performed a three-round Delphi international consensus study to generate standardized names and anatomical descriptions of upper and lower limb regional anesthetic techniques...
November 22, 2023: Regional Anesthesia and Pain Medicine
#29
JOURNAL ARTICLE
Anja Albrecht, Verena Behringer, Oliver Zierau, Christian Hannig
Oral health is a crucial aspect of overall well-being in both humans and nonhuman primates. Understanding the oral pathologies and dental conditions in apes can provide valuable insights into their evolutionary history, dietary habits, and overall health. The present study evaluates dental findings in wild great apes from museum specimens to gain insights into the influence of natural nutrition on dental health. Complete macerated skulls of wild, adult great apes from the collection of the Museum of Natural History, Berlin, Germany, were examined...
December 2, 2023: American Journal of Primatology
#30
JOURNAL ARTICLE
Barbara Fuenzalida, Christiane Albrecht
Cholesterol transport across the placenta must be tightly regulated to avoid a deficiency or an oversupply of cholesterol which is transferred from the mother to the fetus. In trophoblasts, the transport of cholesterol across the cell membrane is mainly mediated by the ATP-binding transporters, ABCA1 and ABCG1. The localization of the transporters at the apical and basal sides of syncytiotrophoblasts has been described. A frequently used method to quantify the amount of cholesterol that cells are capable of exporting is the cholesterol efflux assay...
2024: Methods in Molecular Biology
#31
JOURNAL ARTICLE
Jonas Zaugg, Christiane Albrecht
The placenta maintains the balance between nutrition and growth control of the fetus through selective and regulated supply of macronutrients such as carbohydrates, proteins, lipids, and critical micronutrients. Perturbations in the balanced supply of nutrients as found in gestational diseases and altered fetal development have been associated with changes in amino acid transport proteins, such as the System L amino acid heterodimeric exchangers LAT1/SLC7A5 and LAT2/SLC7A8. Syncytiotrophoblasts (STB) form the crucial cell layer at the placental barrier coordinating the transfer of essential amino acids such as leucine from the maternal to the fetal circulation...
2024: Methods in Molecular Biology
#32
JOURNAL ARTICLE
Rainer Albrecht, Tanguy Espejo, Henk B Riedel, Søren K Nissen, Jay Banerjee, Simon P Conroy, Thomas Dreher-Hummel, Mikkel Brabrand, Roland Bingisser, Christian H Nickel
PURPOSE: The Clinical Frailty Scale (CFS) allows health care providers to quickly stratify older patients, to support clinical decision-making. However, few studies have evaluated the CFS interrater reliability (IRR) in Emergency Departments (EDs), and the freely available smartphone application for CFS assessment was never tested for reliability. This study aimed to evaluate the interrater reliability of the Clinical Frailty Scale (CFS) ratings between experienced and unexperienced staff (ED clinicians and a study team (ST) of medical students supported by a smartphone application to assess the CFS), and to determine the feasibility of CFS assignment in patients aged 65 or older at triage...
November 16, 2023: European Geriatric Medicine
#33
Udo Rolle, Wolf O Bechstein, Claus Fahlenbach, Günther Heller, Hans-Joachim Meyer, Ekkehard Schuler, Albrecht Stier, Beate Waibel, Elke Jeschke, Christian Günster, Matthias Maneck
BACKGROUND: Appendectomy in children is performed either laparoscopically (LA) or by open surgery (OA). We studied whether, and how, the outcome is affected by the technique used and by the intraoperative conversion of LA to OA. METHODS: We analyzed routine data from children and adolescents in three age groups (1-5 years, 6-12 years, and 13-17 years) who were insured by the AOK statutory health insurance carrier in Germany and who underwent appendectomy in the period 2017-2019...
January 26, 2024: Deutsches Ärzteblatt International
#34
JOURNAL ARTICLE
Kien Vu Trung, Christian Heise, Einas Abou-Ali, Francesco Auriemma, Elias Karam, Sophia E van der Wiel, Marco J Bruno, Fabrice Caillol, Marc Giovannini, Viliam Masaryk, Uwe Will, Andrea Anderloni, Enrique Pérez-Cuadrado-Robles, Ana Dugic, Benjamin Meier, Woo H Paik, Maria C Petrone, Dörte Wichmann, Mario Dinis-Ribeiro, Tiago C Gonçalves, Edris Wedi, Arthur Schmidt, Aiste Gulla, Albrecht Hoffmeister, Jonas Rosendahl, Jean Philippe Ratone, Rita Saadeh, Alessandro Repici, Pierre Deprez, Alain Sauvanet, Francois R Souche, Jean M Fabre, Steffen Muehldorfer, Karel Caca, Matthias Löhr, Patrick Michl, Sebastian Krug, Sara Regner, Sebastien Gaujoux, Marcus Hollenbach
BACKGROUND AND AIMS: Ampullary lesions (AL) of the minor duodenal papilla are extremely rare. Endoscopic papillectomy (EP) is a routinely used treatment for AL of the major duodenal papilla but the role of EP for minor AL has not been accurately studied. METHODS: We identified 20 patients with AL of minor duodenal papilla out of the multicentric database from the ESAP study that included 1422 EPs. We used the propensity score matching (nearest-neighbor method), to match these cases with ampullary lesions of the major duodenal papilla based on age, gender, histologic subtype and size of the lesion in a 1:2-ratio...
November 9, 2023: Gastrointestinal Endoscopy
#35
JOURNAL ARTICLE
Carolin Balloff, Carolina Bandlow, Michael Bernhard, Timo Brandenburger, Patricia Bludau, Saskia Elben, Torsten Feldt, Christian J Hartmann, Elisa Heinen, Jens Ingwersen, Corinna Jansen, Björn-Erik O Jensen, Detlef Kindgen-Milles, Tom Luedde, Iris-Katharina Penner, Isabel Slink, Kim Stramm, Ann-Kathrin Telke, Jörg Timm, Lana Vetterkind, Christian Vollmer, Georg Wolff, Alfons Schnitzler, Sven G Meuth, Stefan J Groiss, Philipp Albrecht
Neurological manifestations of coronavirus disease 2019 (COVID-19) have been frequently described. In this prospective study of hospitalized COVID-19 patients without a history of neurological conditions, we aimed to analyze their prevalence and prognostic value based on established, standardized and objective methods. Patients were investigated using a multimodal electrophysiological approach, accompanied by neuropsychological and neurological examinations. Prevalence rates of central (CNS) and peripheral (PNS) nervous system affections were calculated and the relationship between neurological affections and mortality was analyzed using Firth logistic regression models...
November 10, 2023: Scientific Reports
#36
JOURNAL ARTICLE
Julius Tumusiime, Grace Kagoro-Rugunda, Casim Umba Tolo, Daisy Namirembe, Ruben Schols, Cyril Hammoud, Christian Albrecht, Tine Huyse
BACKGROUND: Urogenital schistosomiasis caused by the parasitic blood fluke Schistosoma haematobium is the most common form of that constitutes a majority of over 240 million schistosomiasis cases. The enigmatic absence of urogenital schistosomiasis in Uganda has, until now, been attributed to the absence of substantial populations of suitable snail intermediate hosts. METHODS: Malacological surveys were carried out in 73 sites southeast of Lake Albert, Uganda in October and November 2020...
November 3, 2023: Parasites & Vectors
#37
JOURNAL ARTICLE
Andreas Mock, Maria-Veronica Teleanu, Simon Kreutzfeldt, Christoph E Heilig, Jennifer Hüllein, Lino Möhrmann, Arne Jahn, Dorothea Hanf, Irina A Kerle, Hans Martin Singh, Barbara Hutter, Sebastian Uhrig, Martina Fröhlich, Olaf Neumann, Andreas Hartig, Sascha Brückmann, Steffen Hirsch, Kerstin Grund, Nicola Dikow, Daniel B Lipka, Marcus Renner, Irfan Ahmed Bhatti, Leonidas Apostolidis, Richard F Schlenk, Christian P Schaaf, Albrecht Stenzinger, Evelin Schröck, Daniel Hübschmann, Christoph Heining, Peter Horak, Hanno Glimm, Stefan Fröhling
Analysis of selected cancer genes has become an important tool in precision oncology but cannot fully capture the molecular features and, most importantly, vulnerabilities of individual tumors. Observational and interventional studies have shown that decision-making based on comprehensive molecular characterization adds significant clinical value. However, the complexity and heterogeneity of the resulting data are major challenges for disciplines involved in interpretation and recommendations for individualized care, and limited information exists on how to approach multilayered tumor profiles in clinical routine...
October 26, 2023: NPJ Precision Oncology
#38
JOURNAL ARTICLE
Thu Nguyen Minh Pham, Natarajan Perumal, Caroline Manicam, Marion Basoglu, Stefan Eimer, Dominik C Fuhrmann, Claus U Pietrzik, Albrecht M Clement, Hagen Körschgen, Jana Schepers, Christian Behl
Accumulation of misfolded proteins or perturbation of calcium homeostasis leads to endoplasmic reticulum (ER) stress and is linked to the pathogenesis of neurodegenerative diseases. Hence, understanding the ability of neuronal cells to cope with chronic ER stress is of fundamental interest. Interestingly, several brain areas uphold functions that enable them to resist challenges associated with neurodegeneration. Here, we established novel clonal mouse hippocampal (HT22) cell lines that are resistant to prolonged (chronic) ER stress induced by thapsigargin (TgR) or tunicamycin (TmR) as in vitro models to study the adaption to ER stress...
October 20, 2023: Redox Biology
#39
JOURNAL ARTICLE
Rebecca Wicklein, Charmaine Yam, Christina Noll, Lilian Aly, Nicolas Banze, Eva Feodora Romahn, Elisabeth Wolf, Bernhard Hemmer, Frederike C Oertel, Hanna Zimmermann, Philipp Albrecht, Marius Ringelstein, Carmen Baumann, Nikolaus Feucht, Josef Penkava, Joachim Havla, Jonathan A Gernert, Christian Mardin, Eleni S Vasileiou, Anneke Van Der Walt, Omar Al-Louzi, Sergio Cabello, Angela Vidal-Jordana, Julia Krämer, Heinz Wiendl, Jana Lizrova Preiningerova, Olga Ciccarelli, Elena Garcia-Martin, Veronika Kana, Peter A Calabresi, Friedemann Paul, Shiv Saidha, Axel Petzold, Ahmed T Toosy, Benjamin Knier
BACKGROUND AND OBJECTIVES: Optical coherence tomography angiography (OCTA) is a noninvasive high-resolution imaging technique for assessing the retinal vasculature and is increasingly used in various ophthalmologic, neuro-ophthalmologic, and neurologic diseases. To date, there are no validated consensus criteria for quality control (QC) of OCTA. Our study aimed to develop criteria for OCTA quality assessment. METHODS: To establish criteria through (1) extensive literature review on OCTA artifacts and image quality to generate standardized and easy-to-apply OCTA QC criteria, (2) application of OCTA QC criteria to evaluate interrater agreement, (3) identification of reasons for interrater disagreement, revision of OCTA QC criteria, development of OCTA QC scoring guide and training set, and (4) validation of QC criteria in an international, interdisciplinary multicenter study...
November 2023: Neurology® Neuroimmunology & Neuroinflammation
#40
JOURNAL ARTICLE
Silvia Hernandez-Duran, Johannes Walter, Bedjan Behmanesh, Joshua D Bernstock, Marcus Czabanka, Nazife Dinc, Daniel Dubinski, Thomas M Freiman, Albrecht Günther, Kara Hellmuth, Eva Herrmann, Juergen Konczalla, Ilko Maier, Ruzanna Melkonian, Dorothee Mielke, Sebastian Johannes Müller, Paul Naser, Veit Rohde, Jan Hendrik Schaefer, Christian Senft, Alexander Storch, Andreas Unterberg, Uwe Walter, Matthias Wittstock, Florian Gessler, Sae-Yeon Won
BACKGROUND AND OBJECTIVES: Space-occupying cerebellar stroke (SOCS) when coupled with neurological deterioration represents a neurosurgical emergency. Although current evidence supports surgical intervention in such patients with SOCS and rapid neurological deterioration, the optimal surgical methods/techniques to be applied remain a matter of debate. METHODS: We conducted a retrospective, multicenter study of patients undergoing surgery for SOCS. Patients were stratified according to the type of surgery as (1) suboccipital decompressive craniectomy (SDC) or (2) suboccipital craniotomy with concurrent necrosectomy...
October 6, 2023: Neurosurgery
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