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Christiane albrecht

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https://www.readbyqxmd.com/read/29792729/90-kvp-low-tube-voltage-ct-pulmonary-angiography-in-combination-with-advanced-modelled-iterative-reconstruction-algorithm-effects-on-radiation-dose-image-quality-and-diagnostic-accuracy-for-the-detection-of-pulmonary-embolism
#1
Doris Leithner, Tatjana Gruber-Rouh, Martin Beeres, Julian L Wichmann, Scherwin Mahmoudi, Simon S Martin, Lukas Lenga, Moritz H Albrecht, Christian Booz, Thomas J Vogl, Jan-Erik Scholtz
OBJECTIVE: To evaluate low-tube-voltage 90-kVp computed tomography pulmonary angiography (CTPA) with advanced modelled iterative reconstruction algorithm (Admire) compared to 120-kVp equivalent dual-energy acquisition with regards to radiation exposure, image quality, and diagnostic accuracy for pulmonary embolism (PE) assessment. METHODS: CTPA studies of 40 patients with suspected PE (56.7 ± 16.3 years) performed on a third-generation 192-slice dual-source CT scanner were retrospectively included...
May 24, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29761371/tolerability-and-efficacy-of-deferasirox-in-patients-with-transfusional-iron-overload-results-from-a-german-2-year-non-interventional-study
#2
Florian Nolte, Holger Nückel, Burkhard Schmidt, Thomas Geer, Oleg Rubanov, Holger Hebart, Andrea Jarisch, Stefan Albrecht, Christiane Johr, Christiane Schumann, Wolf-Karsten Hofmann
BACKGROUND: Iron overload (IOL) due to repetitive transfusions of packed red blood cells (pRBC) has a major impact on morbidity and mortality in patients with inherited bone marrow failure syndromes and hemoglobinopathies such as thalassemia and sickle cell disease. However, whether IOL influences the outcome of elderly patients with myeloid malignancies is not yet clear. Moreover, clinical trials have reported high drop-out rates during treatment with the oral iron chelator deferasirox (DFX)...
May 14, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29744572/protective-potential-of-dimethyl-fumarate-in-a-mouse-model-of-thalamocortical-demyelination
#3
Manuela Cerina, Venu Narayanan, Anna Delank, Patrick Meuth, Stephanie Graebenitz, Kerstin Göbel, Alexander M Herrmann, Stefanie Albrecht, Thiemo Daldrup, Thomas Seidenbecher, Ali Gorji, Tanja Kuhlmann, Heinz Wiendl, Christoph Kleinschnitz, Erwin J Speckmann, Hans-Christian Pape, Sven G Meuth, Thomas Budde
Alterations in cortical cellular organization, network functionality, as well as cognitive and locomotor deficits were recently suggested to be pathological hallmarks in multiple sclerosis and corresponding animal models as they might occur following demyelination. To investigate functional changes following demyelination in a well-defined, topographically organized neuronal network, in vitro and in vivo, we focused on the primary auditory cortex (A1) of mice in the cuprizone model of general de- and remyelination...
May 9, 2018: Brain Structure & Function
https://www.readbyqxmd.com/read/29734858/current-and-future-applications-of-ct-coronary-calcium-assessment
#4
Christian Tesche, Taylor M Duguay, U Joseph Schoepf, Marly van Assen, Carlo N De Cecco, Moritz H Albrecht, Akos Varga-Szemes, Richard R Bayer, Ullrich Ebersberger, John W Nance, Christian Thilo
Computed tomographic (CT) coronary artery calcium scoring (CAC) has been validated as a well-established screening method for cardiovascular risk stratification and treatment management that is used in addition to traditional risk factors. The purpose of this review is to present an update on current and future applications of CAC. Areas covered: The topic of CAC is summarized from its introduction to current application with focus on the validation and clinical integration including cardiovascular risk prediction and outcome, cost-effectiveness, impact on downstream medical testing, and the technical advances in scanner and software technology that are shaping the future of CAC...
May 8, 2018: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/29732588/contrast-enhanced-ultrasound-in-pulmonary-lymphoma-a-small-pilot-study
#5
Corinna Trenker, Christian Wilhelm, Albrecht Neesse, Peter Rexin, Christian Görg
Here, we describe the appearance and pattern of pulmonary lymphoma on B-mode imaging and with contrast-enhanced ultrasound (CEUS). From July 2009 to December 2015, 6 patients with histologically or cytologically confirmed lymphoma of the lung were examined by B-mode imaging, followed by CEUS. A retrospective analysis of the imaging data was performed with respect to the time to enhancement, pulmonary artery (PA) and bronchial artery, echogenicity (hypoechoic, isoechoic, or hyperechoic), and homogeneity (homogeneous or inhomogeneous) of the contrast enhancement...
May 6, 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29705238/hcv-modifies-egf-signalling-and-upregulates-production-of-cxcr2-ligands-role-in-inflammation-and-antiviral-immune-response
#6
Christina Groepper, Kerstin Rufinatscha, Nadja Schröder, Sabine Stindt, Christian Ehlting, Ute Albrecht, Hans H Bock, Ralf Bartenschlager, Dieter Häussinger, Johannes G Bode
BACKGROUND & AIMS: To affect immune response and inflammation, the hepatitis C virus (HCV) substantially influences intercellular communication pathways that are decisive for immune cell recruitment. The present study investigates mechanisms by which HCV modulates chemokine-mediated intercellular communication of the infected cells. METHODS: Chemokine expression is studied in HCVcc -infected cell lines or cell lines harbouring a subgenomic replicon as well as in serum samples from patients...
April 26, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29690361/lost-species-in-cameroon-rediscovery-of-the-endangered-freshwater-crab-louisea-balssi-bott-1959-brachyura-potamonautidae-with-notes-on-its-ecology-and-conservation
#7
Pierre A Mvogo Ndongo, Thomas von Rintelen, Christian Albrecht, Joseph L Tamesse, Neil Cumberlidge
The rare and endangered Cameroonian potamonautid freshwater crab, Louisea balssi (Bott, 1959), was recently rediscovered after not having been seen for the last 109 years and presumed extinct. The new specimens of L. balssi were collected from the Southwest Region of Cameroon, about 80 km from the type locality, and include the first adult male to be recorded for this species. A redescription of L. balssi, which includes for the first time the adult characters of the male gonopods and chelipeds, is provided...
March 14, 2018: Zootaxa
https://www.readbyqxmd.com/read/29686316/publisher-correction-nfat-calcineurin-signaling-promotes-oligodendrocyte-differentiation-and-myelination-by-transcription-factor-network-tuning
#8
Matthias Weider, Laura Julia Starost, Katharina Groll, Melanie Küspert, Elisabeth Sock, Miriam Wedel, Franziska Fröb, Christian Schmitt, Tina Baroti, Anna C Hartwig, Simone Hillgärtner, Sandra Piefke, Tanja Fadler, Marc Ehrlich, Corinna Ehlert, Martin Stehling, Stefanie Albrecht, Ammar Jabali, Hans R Schöler, Jürgen Winkler, Tanja Kuhlmann, Michael Wegner
The originally published version of this Article omitted Tanja Kuhlmann and Michael Wegner as jointly supervising authors. This has now been corrected in both the PDF and HTML versions of the Article.
April 23, 2018: Nature Communications
https://www.readbyqxmd.com/read/29686286/placental-mir-340-mediates-vulnerability-to-activity-based-anorexia-in-mice
#9
Mariana Schroeder, Mira Jakovcevski, Tamar Polacheck, Yonat Drori, Alessia Luoni, Simone Röh, Jonas Zaugg, Shifra Ben-Dor, Christiane Albrecht, Alon Chen
Anorexia nervosa (AN) is a devastating eating disorder characterized by self-starvation that mainly affects women. Its etiology is unknown, which impedes successful treatment options leading to a limited chance of full recovery. Here, we show that gestation is a vulnerable window that can influence the predisposition to AN. By screening placental microRNA expression of naive and prenatally stressed (PNS) fetuses and assessing vulnerability to activity-based anorexia (ABA), we identify miR-340 as a sexually dimorphic regulator involved in prenatal programming of ABA...
April 23, 2018: Nature Communications
https://www.readbyqxmd.com/read/29607450/multiple-reaction-monitoring-targeted-lc-ms-analysis-of-potential-cell-death-marker-proteins-for-increased-bioprocess-control
#10
Simone Albrecht, Christian Kaisermayer, David Reinhart, Monica Ambrose, Renate Kunert, Anna Lindeberg, Jonathan Bones
The monitoring of protein biomarkers for the early prediction of cell stress and death is a valuable tool for process characterization and efficient biomanufacturing control. A representative set of six proteins, namely GPDH, PRDX1, LGALS1, CFL1, TAGLN2 and MDH, which were identified in a previous CHO-K1 cell death model using discovery LC-MSE was translated into a targeted liquid chromatography multiple reaction monitoring mass spectrometry (LC-MRM-MS) platform and verified. The universality of the markers was confirmed in a cell growth model for which three Chinese hamster ovary host cell lines (CHO-K1, CHO-S, CHO-DG44) were grown in batch culture in two different types of basal media...
April 2, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29581218/ripheart-remote-ischemic-preconditioning-for-heart-surgery-study-myocardial-dysfunction-postoperative-neurocognitive-dysfunction-and-1-year-follow-up
#11
Patrick Meybohm, Madeline Kohlhaas, Christian Stoppe, Matthias Gruenewald, Jochen Renner, Berthold Bein, Martin Albrecht, Jochen Cremer, Mark Coburn, Gereon Schaelte, Andreas Boening, Bernd Niemann, Michael Sander, Jan Roesner, Frank Kletzin, Haitham Mutlak, Sabine Westphal, Rita Laufenberg-Feldmann, Marion Ferner, Ivo F Brandes, Martin Bauer, Sebastian N Stehr, Andreas Kortgen, Maria Wittmann, Georg Baumgarten, Tanja Meyer-Treschan, Peter Kienbaum, Matthias Heringlake, Julika Schoen, Sascha Treskatsch, Thorsten Smul, Ewa Wolwender, Thomas Schilling, Georg Fuernau, Holger Bogatsch, Oana Brosteanu, Dirk Hasenclever, Kai Zacharowski
BACKGROUND: Remote ischemic preconditioning (RIPC) has been suggested to protect against certain forms of organ injury after cardiac surgery. Previously, we reported the main results of RIPHeart (Remote Ischemic Preconditioning for Heart Surgery) Study, a multicenter trial randomizing 1403 cardiac surgery patients receiving either RIPC or sham-RIPC. METHODS AND RESULTS: In this follow-up paper, we present 1-year follow-up of the composite primary end point and its individual components (all-cause mortality, myocardial infarction, stroke and acute renal failure), in a sub-group of patients, intraoperative myocardial dysfunction assessed by transesophageal echocardiography and the incidence of postoperative neurocognitive dysfunction 5 to 7 days and 3 months after surgery...
March 26, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29572082/correlation-of-tricuspid-regurgitation-and-new-pacemaker-implantation-in-patients-undergoing-transcatheter-aortic-valve-implantation
#12
Dimitry Schewel, Jury Schewel, Michael Schlüter, Felix Kreidel, Tobias Schmidt, Michael Schmoeckel, Albrecht Elsässer, Karl-Heinz Kuck, Christian Frerker
AIMS: Conduction abnormalities (CA), in particular complete atrioventricular block (CAVB), requiring permanent pacemaker (PPM) implantation, are frequent complications after transcatheter aortic valve implantation (TAVI) in patients with severe aortic stenosis (AS). However, the potential mechanisms are still incompletely understood. The objective of this retrospective study was to determine further predictors of CAVB after TAVI in patients without the known predictors. METHODS AND RESULTS: This study included patients without prior CA/PPM who underwent TAVI of a balloon-expandable valve (Sapien or Sapien XT or Sapien 3)...
June 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29571783/beam-hardening-in-70-kv-coronary-ct-angiography-artifact-reduction-using-an-advanced-post-processing-algorithm
#13
Moritz H Albrecht, Matthew W Bickford, U Joseph Schoepf, Christian Tesche, Domenico De Santis, Marwen Eid, Brian E Jacobs, Taylor M Duguay, Bernhard T Schmidt, Christian Canstein, Akos Varga-Szemes, Doris Leithner, Simon Martin, Thomas J Vogl, Carlo N De Cecco
PURPOSE: To investigate the effect of an iterative beam-hardening correction algorithm (iBHC) on artifact reduction and image quality in coronary CT angiography (cCTA) with low tube voltage. MATERIAL AND METHODS: Thirty-six patients (17 male, mean age, 57.3 ± 14.5 years) were prospectively enrolled in this IRB-approved study and underwent 70-kV cCTA using a third-generation dual-source CT scanner. Images were reconstructed using a standard algorithm (Bv36) both with and without the iBHC technique...
April 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/29558744/the-angiotensin-ii-type-1-receptor-antagonist-losartan-affects-nhe1-dependent-melanoma-cell-behavior
#14
Daniel Navin Olschewski, Verena Hofschröer, Nikolaj Nielsen, Daniela G Seidler, Albrecht Schwab, Christian Stock
BACKGROUND/AIMS: The peptide hormone angiotensin II (ATII) plays a prominent role in regulating vasoconstriction and blood pressure. Its primary target is the angiotensin II receptor type 1 (AT1), the stimulation of which induces an increase in cytosolic [Ca2+] and calmodulin activation. Ca2+-bound (activated) calmodulin stimulates the activity of the Na+/ H+ exchanger isoform 1 (NHE1); and increased NHE1 activity is known to promote melanoma cell motility. The competitive AT1 receptor inhibitor losartan is often used to lower blood pressure in hypertensive patients...
March 16, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29544958/reg3%C3%AE-is-associated-with-cardiac-inflammation-and-provides-prognostic-information-in-patients-with-acute-coronary-syndrome
#15
Holger Lörchner, Christian Widera, Yunlong Hou, Albrecht Elsässer, Henning Warnecke, Evangelos Giannitsis, Jean-Sebastien Hulot, Thomas Braun, Kai C Wollert, Jochen Pöling
BACKGROUND: Regenerating islet-derived protein 3 beta (Reg3β) is a cardiomyocyte-derived chemokine for macrophages that is upregulated after myocardial infarction (MI) in mice. Here, we hypothesized that monitoring Reg3β expression might provide specific information on the degree of cardiac inflammation, which is a key determinant in disease progression and prognosis of patients with acute coronary syndrome (ACS). METHODS AND RESULTS: The expression of Reg3β and other inflammatory markers including C-reactive protein (CRP) and myeloperoxidase (MPO) was measured by immunoblotting at serial time points in the hearts and serum of mice with acute MI...
May 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29532224/diagnostic-and-therapeutic-single-operator-cholangiopancreatoscopy-with-spyglassds%C3%A2-results-of-a-multicenter-retrospective-cohort-study
#16
Felicia Turowski, Ulrich Hügle, Arno Dormann, Matthias Bechtler, Ralf Jakobs, Uwe Gottschalk, Ellen Nötzel, Dirk Hartmann, Albrecht Lorenz, Frank Kolligs, Wilfried Veltzke-Schlieker, Andreas Adler, Olaf Becker, Bertram Wiedenmann, Nataly Bürgel, Hanno Tröger, Michael Schumann, Severin Daum, Britta Siegmund, Christian Bojarski
BACKGROUND AND AIMS: The aim of the study was to evaluate the usefulness and diagnostic and therapeutic outcome of the single-operator cholangiopancreatoscopy (SOC) with SpyGlassDS™. METHODS: In a retrospective multicenter study between November 2015 and January 2017, SpyGlassDS™ procedures were analyzed in participating centers. Indications, accuracy of SOC-guided biopsies, management of large bile duct stones, and complications were analyzed. Follow-up was 4 months...
March 12, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29529259/management-of-therapeutic-anticoagulation-in-patients-with-intracerebral-haemorrhage-and-mechanical-heart-valves
#17
Joji B Kuramatsu, Jochen A Sembill, Stefan T Gerner, Maximilian I Sprügel, Manuel Hagen, Sebastian S Roeder, Matthias Endres, Karl Georg Haeusler, Jan Sobesky, Johannes Schurig, Sarah Zweynert, Miriam Bauer, Peter Vajkoczy, Peter A Ringleb, Jan Purrucker, Timolaos Rizos, Jens Volkmann, Wolfgang Müllges, Peter Kraft, Anna-Lena Schubert, Frank Erbguth, Martin Nueckel, Peter D Schellinger, Jörg Glahn, Ulrich J Knappe, Gereon R Fink, Christian Dohmen, Henning Stetefeld, Anna Lena Fisse, Jens Minnerup, Georg Hagemann, Florian Rakers, Heinz Reichmann, Hauke Schneider, Sigrid Wöpking, Albert Christian Ludolph, Sebastian Stösser, Hermann Neugebauer, Joachim Röther, Peter Michels, Michael Schwarz, Gernot Reimann, Hansjörg Bäzner, Henning Schwert, Joseph Claßen, Dominik Michalski, Armin Grau, Frederick Palm, Christian Urbanek, Johannes C Wöhrle, Fahid Alshammari, Markus Horn, Dirk Bahner, Otto W Witte, Albrecht Günther, Gerhard F Hamann, Hannes Lücking, Arnd Dörfler, Stephan Achenbach, Stefan Schwab, Hagen B Huttner
Aims: Evidence is lacking regarding acute anticoagulation management in patients after intracerebral haemorrhage (ICH) with implanted mechanical heart valves (MHVs). Our objective was to investigate anticoagulation reversal and resumption strategies by evaluating incidences of haemorrhagic and thromboembolic complications, thereby defining an optimal time-window when to restart therapeutic anticoagulation (TA) in patients with MHV and ICH. Methods and results: We pooled individual patient-data (n = 2504) from a nationwide multicentre cohort-study (RETRACE, conducted at 22 German centres) and eventually identified MHV-patients (n = 137) with anticoagulation-associated ICH for outcome analyses...
May 14, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29527098/disorders-of-spermatogenesis-perspectives-for-novel-genetic-diagnostics-after-20-years-of-unchanged-routine
#18
REVIEW
Frank Tüttelmann, Christian Ruckert, Albrecht Röpke
Infertility is a common condition estimated to affect 10-15% of couples. The clinical causes are attributed in equal parts to the male and female partners. Diagnosing male infertility mostly relies on semen (and hormone) analysis, which results in classification into the two major phenotypes of oligo- and azoospermia. The clinical routine analyses have not changed over the last 20 years and comprise screening for chromosomal aberrations and Y‑chromosomal azoospermia factor deletions. These tests establish a causal genetic diagnosis in about 4% of unselected men in infertile couples and 20% of azoospermic men...
2018: Medizinische Genetik: Mitteilungsblatt des Berufsverbandes Medizinische Genetik E.V
https://www.readbyqxmd.com/read/29500351/nfat-calcineurin-signaling-promotes-oligodendrocyte-differentiation-and-myelination-by-transcription-factor-network-tuning
#19
Matthias Weider, Laura Julia Starost, Katharina Groll, Melanie Küspert, Elisabeth Sock, Miriam Wedel, Franziska Fröb, Christian Schmitt, Tina Baroti, Anna C Hartwig, Simone Hillgärtner, Sandra Piefke, Tanja Fadler, Marc Ehrlich, Corinna Ehlert, Martin Stehling, Stefanie Albrecht, Ammar Jabali, Hans R Schöler, Jürgen Winkler, Tanja Kuhlmann, Michael Wegner
Oligodendrocytes produce myelin for rapid transmission and saltatory conduction of action potentials in the vertebrate central nervous system. Activation of the myelination program requires several transcription factors including Sox10, Olig2, and Nkx2.2. Functional interactions among them are poorly understood and important components of the regulatory network are still unknown. Here, we identify Nfat proteins as Sox10 targets and regulators of oligodendroglial differentiation in rodents and humans. Overall levels and nuclear fraction increase during differentiation...
March 2, 2018: Nature Communications
https://www.readbyqxmd.com/read/29499643/identification-of-placental-nutrient-transporters-associated-with-intrauterine-growth-restriction-and-pre-eclampsia
#20
Xiao Huang, Pascale Anderle, Lu Hostettler, Marc U Baumann, Daniel V Surbek, Edgar C Ontsouka, Christiane Albrecht
BACKGROUND: Gestational disorders such as intrauterine growth restriction (IUGR) and pre-eclampsia (PE) are main causes of poor perinatal outcomes worldwide. Both diseases are related with impaired materno-fetal nutrient transfer, but the crucial transport mechanisms underlying IUGR and PE are not fully elucidated. In this study, we aimed to identify membrane transporters highly associated with transplacental nutrient deficiencies in IUGR/PE. RESULTS: In silico analyses on the identification of differentially expressed nutrient transporters were conducted using seven eligible microarray datasets (from Gene Expression Omnibus), encompassing control and IUGR/PE placental samples...
March 2, 2018: BMC Genomics
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