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JOURNAL ARTICLE
Bertram Häussler, Barbara Schmalfeldt, Senta Häussler, Angela Köninger, Stefan Loos, Gert Naumann, Anton Scharl, Christian J Thaler, Martin Weiss, Martin Albrecht
BACKGROUND: Recent years have seen a considerable shift from male doctors to female doctors in the field of gynecology. Female doctors are traditionally more involved with planning and maintaining their family. For gynecology, this could be associated with a risk that research activities will decrease, particularly if results are published in scientific journals. METHODS: In view of this shift, a comparative observational study was carried for 2022 in which 1306 publications were matched to 1786 female and male doctors reported on the websites of the 44 locations of university gynecology departments in Germany...
April 2024: Geburtshilfe und Frauenheilkunde
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JOURNAL ARTICLE
Julius Tumusiime, Noelia Valderrama Bhraunxs, Grace Kagoro-Rugunda, Daisy Namirembe, Christian Albrecht, Ronald Twongyirwe, Casim Umba Tolo, Liesbet Jacobs, Tine Huyse
INTRODUCTION: Schistosomiasis and fasciolosis are snail-borne diseases of great medical and veterinary health importance. The World Health Organization recommends complementing drug treatment with snail control and community involvement for disease elimination, but there is a general lack of snail experts and hence snail distribution data. Therefore, we adopted a citizen science approach and involved citizens in the monitoring of medically and veterinary important snail taxa. MATERIALS AND METHODS: Snail data was collected weekly by 25 trained citizen scientists (CSs) at 76 sites around southern Lake Albert (Uganda) for 20 months...
April 4, 2024: PLoS Neglected Tropical Diseases
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JOURNAL ARTICLE
Clemens Eckel, Won-Keun Kim, Dagmar Sötemann, Christina Grothusen, Vedat Tiyerili, Guido Dohmen, Matthias Renker, Efstratios I Charitos, Christian W Hamm, Yeong-Hoon Choi, Albrecht Elsässer, Helge Möllmann, Johannes Blumenstein
BACKGROUND: Comparative data on transcatheter self-expanding ACURATE neo2 (NEO2) and balloon-expandable SAPIEN 3 Ultra prostheses in technically challenging anatomy of severe aortic valve calcified aortic annuli are scarce. METHODS: A total of 1987 patients with severe native aortic stenosis treated with the self-expanding NEO2 (n=1457) or balloon-expandable SAPIEN 3 Ultra (n=530) from January 2017 to April 2023 were evaluated. The primary end point was procedural outcome according to the Valve Academic Research Consortium 3 definitions...
March 26, 2024: Circulation. Cardiovascular Interventions
#4
JOURNAL ARTICLE
Jonas Zaugg, Jorge Lopez-Tello, Barbara Musial, Owen R Vaughan, Abigail L Fowden, Christiane Albrecht, Amanda N Sferruzzi-Perri
Obesity and gestational diabetes (GDM) impact fetal growth during pregnancy. Iron is an essential micronutrient needed for energy-intense feto-placental development, but if mis-handled can lead to oxidative stress and ferroptosis (iron-dependent cell death). In a mouse model showing maternal obesity and glucose intolerance, we investigated the association of materno-fetal iron handling and placental ferroptosis, oxidative damage and stress signalling activation with fetal growth. Female mice were fed a standard chow or high fat, high sugar (HFHS) diet during pregnancy and outcomes were measured at day (d)16 or d19 of pregnancy...
March 25, 2024: Cellular and Molecular Life Sciences: CMLS
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JOURNAL ARTICLE
Sae-Yeon Won, Silvia Hernández-Durán, Bedjan Behmanesh, Joshua D Bernstock, Marcus Czabanka, Nazife Dinc, Daniel Dubinski, Thomas M Freiman, Albrecht Günther, Kara Hellmuth, Eva Herrmann, Juergen Konczalla, Ilko Maier, Ruzanna Melkonian, Dorothee Mielke, Paul Naser, Veit Rohde, Christian Senft, Alexander Storch, Andreas Unterberg, Johannes Walter, Uwe Walter, Matthias Wittstock, Jan Hendrik Schaefer, Florian Gessler
IMPORTANCE: According to the current American Heart Association/American Stroke Association guidelines, decompressive surgery is indicated in patients with cerebellar infarcts that demonstrate severe cerebellar swelling. However, there is no universal definition of swelling and/or infarct volume(s) available to support a decision for surgery. OBJECTIVE: To evaluate functional outcomes in surgically compared with conservatively managed patients with cerebellar infarcts...
February 26, 2024: JAMA Neurology
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JOURNAL ARTICLE
Amit Chanda, Christian Holzmann, Noah Schulz, Aladin Ullrich, Derick DeTellem, Manfred Albrecht, Miela Gross, Caroline A Ross, Dario A Arena, Manh-Huong Phan, Hariharan Srikanth
The magnon propagation length, ⟨ξ⟩, of a ferro-/ferrimagnet (FM) is one of the key factors that controls the generation and propagation of thermally driven magnonic spin current in FM/heavy metal (HM) bilayer based spincaloritronic devices. For the development of a complete physical picture of thermally driven magnon transport in FM/HM bilayers over a wide temperature range, it is of utmost importance to understand the respective roles of temperature-dependent Gilbert damping (α) and effective magnetic anisotropy ( K eff ) in controlling the temperature evolution of ⟨ξ⟩...
February 23, 2024: ACS Nano
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JOURNAL ARTICLE
Zadoki Tabo, Lutz Breuer, Codalli Fabia, Gorata Samuel, Christian Albrecht
Schistosomiasis, a prevalent water-borne disease second only to malaria, significantly impacts impoverished rural communities, primarily in Sub-Saharan Africa where over 90% of the severely affected population resides. The disease, majorly caused by Schistosoma mansoni and S. haematobium parasites, relies on freshwater snails, specifically Biomphalaria and Bulinus species, as crucial intermediate host (IH) snails. Targeted snail control is advisable, however, there is still limited knowledge about the community structure of the two genera especially in East Africa...
February 21, 2024: Scientific Reports
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JOURNAL ARTICLE
Friederike A Arlt, Ramona Miske, Marie-Luise Machule, Peter Broegger Christensen, Swantje Mindorf, Bianca Teegen, Kathrin Borowski, Maria Buthut, Rosa Rößling, Elisa Sanchez-Sendin, Scott van Hoof, César Cordero-Gómez, Isabel Bünger, Helena Radbruch, Andrea Kraft, Ilya Ayzenberg, Jaqueline Klausewitz, Niels Hansen, Charles Timäus, Peter Körtvelyessy, Thomas Postert, Kirsten Baur-Seack, Constanze Rost, Robert Brunkhorst, Kathrin Doppler, Niklas Haigis, Gerhard Hamann, Albrecht Kunze, Alexandra Stützer, Matthias Maschke, Nico Melzer, Felix Rosenow, Kai Siebenbrodt, Christian Stenør, Martin Dichgans, Marios K Georgakis, Rong Fang, Gabor C Petzold, Michael Görtler, Inga Zerr, Silke Wunderlich, Ivan Mihaljevic, Paul Turko, Marianne Schmidt Ettrup, Emilie Buchholz, Helle Foverskov Rasmussen, Mahoor Nasouti, Ivan Talucci, Hans M Maric, Stefan H Heinemann, Matthias Endres, Lars Komorowski, Harald Prüss
BACKGROUND: Autoantibodies against the potassium voltage-gated channel subfamily A member 2 (KCNA2) have been described in a few cases of neuropsychiatric disorders, but their diagnostic and pathophysiological role is currently unknown, imposing challenges to medical practice. DESIGN / METHODS: We retrospectively collected comprehensive clinical and paraclinical data of 35 patients with KCNA2 IgG autoantibodies detected in cell-based and tissue-based assays. Patients' sera and cerebrospinal fluid (CSF) were used for characterization of the antigen, clinical-serological correlations, and determination of IgG subclasses...
February 1, 2024: Brain, Behavior, and Immunity
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JOURNAL ARTICLE
Brian Topper, Stefan Kuhn, Alexander Neumann, Alexander R Albrecht, Angel S Flores, Denny Hässner, Sigrun Hein, Christian Hupel, Johannes Nold, Nicoletta Haarlammert, Thomas Schreiber, Mansoor Sheik-Bahae, Arash Mafi
Laser cooling of a 5 cm long, 1 mm diameter ytterbium doped (6.56×1025 ions/m3 ) silica rod by 67 K from room temperature was achieved. For the pump source, a 100 W level ytterbium fiber amplifier was constructed along with a 1032 nm fiber Bragg grating seed laser. Experiments were done in vacuum and monitored with the non-contact differential luminescence thermometry method. Direct measurements of the absorption spectrum as a function of temperature were made, to avoid any possible ambiguities from site-selectivity and deviations from McCumber theory at low temperature...
January 29, 2024: Optics Express
#10
JOURNAL ARTICLE
Mariana Schroeder, Barbara Fuenzalida, Nan Yi, Saira Shahnawaz, Jürg Gertsch, Daniele Pellegata, Edgar Ontsouka, Andrea Leiva, Jaime Gutiérrez, Martin Müller, Marcela A Brocco, Christiane Albrecht
The Developmental Origins of Health and Disease hypothesis sustains that exposure to different stressors during prenatal development prepares the offspring for the challenges to be encountered after birth. We studied the gestational period as a particularly vulnerable window where different stressors can have strong implications for fetal programming of the offspring's life-long metabolic status via alterations of specific placentally expressed nutrient transporters. To study this mechanism, we used a murine prenatal stress model, human preeclampsia, early miscarriage, and healthy placental tissue samples, in addition to in vitro models of placental cells...
January 29, 2024: Metabolism: Clinical and Experimental
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JOURNAL ARTICLE
Miriam Blasi, Jonas Kuon, Heike Lüders, Daniel Misch, Diego Kauffmann-Guerrero, Moritz Hilbrandt, Daniel Kazdal, Roger-Fei Falkenstern-Ge, Björn Hackanson, Sebastian Dintner, Martin Faehling, Martina Kirchner, Anna-Lena Volckmar, Hans-Georg Kopp, Michael Allgäuer, Christian Grohé, Amanda Tufman, Martin Reck, Nikolaj Frost, Albrecht Stenzinger, Michael Thomas, Petros Christopoulos
BACKGROUND: The efficacy of checkpoint inhibitors for non-small cell lung cancer (NSCLC) with MET exon 14 skipping (METΔ14ex) remains controversial. MATERIALS AND METHODS: 110 consecutive METΔ14ex NSCLC patients receiving first-line chemotherapy (CHT) and/or immunotherapy (IO) in 10 German centers between 2016-2022 were analyzed. RESULTS: Combined CHT-IO was given to 35/110 (32%) patients, IO alone to 43/110 (39%), and CHT to 32/110 (29%) upfront...
March 2024: European Journal of Cancer
#12
JOURNAL ARTICLE
Zadoki Tabo, Chester Kalinda, Lutz Breuer, Christian Albrecht
Schistosomiasis, a neglected tropical disease caused by parasitic worms, poses a major public health challenge in economically disadvantaged regions, especially in Sub-Saharan Africa. Climate factors, such as temperature and rainfall patterns, play a crucial role in the transmission dynamics of the disease. This study presents a deterministic model that aims to evaluate the temporal and seasonal transmission dynamics of schistosomiasis by examining the influence of temperature and rainfall over time. Equilibrium states are examined to ascertain their existence and stability employing the center manifold theory, while the basic reproduction number is calculated using the next-generation technique...
March 2024: Infectious Disease Modelling
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JOURNAL ARTICLE
Barbara Fuenzalida, Maria Jose Yañez, Martin Mueller, Hiten D Mistry, Andrea Leiva, Christiane Albrecht
Preeclampsia (PE) poses a considerable risk to the long-term cardiovascular health of both mothers and their offspring due to a hypoxic environment in the placenta leading to reduced fetal oxygen supply. Cholesterol is vital for fetal development by influencing placental function. Recent findings suggest an association between hypoxia, disturbed cholesterol homeostasis, and PE. This study investigates the influence of hypoxia on placental cholesterol homeostasis. Using primary human trophoblast cells and placentae from women with PE, various aspects of cholesterol homeostasis were examined under hypoxic and hypoxia/reoxygenation (H/R) conditions...
February 2024: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
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JOURNAL ARTICLE
Roswitha Siener, Charlotte Ernsten, Jan Speller, Christian Scheurlen, Tilman Sauerbruch, Albrecht Hesse
Nephrolithiasis is a common urologic manifestation of Crohn's disease. The purpose of this study was to investigate the clinical characteristics, intestinal oxalate absorption, and risk factors for urinary stone formation in these patients. In total, 27 patients with Crohn's disease and 27 healthy subjects were included in the present study. Anthropometric, clinical, and 24 h urinary parameters were determined, and the [13 C2 ]oxalate absorption test was performed. Among all patients, 18 had undergone ileal resection, 9 of whom had a history of urinary stones...
January 16, 2024: Nutrients
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JOURNAL ARTICLE
Lucia Alcober-Boquet, Nico Kraus, Lisa Sophie Huber, Rajkumar Vutukuri, Dominik Christian Fuhrmann, Claudia Stross, Liliana Schaefer, Klaus Scholich, Stefan Zeuzem, Albrecht Piiper, Marcel H Schulz, Jonel Trebicka, Christoph Welsch, Cristina Ortiz
17-beta-hydroxysteroid dehydrogenase 13 (HSD17B13), a lipid droplet-associated enzyme, is primarily expressed in the liver and plays an important role in lipid metabolism. Targeted inhibition of enzymatic function is a potential therapeutic strategy for treating steatotic liver disease (SLD). The present study is aimed at investigating the effects of the first selective HSD17B13 inhibitor, BI-3231, in a model of hepatocellular lipotoxicity using human cell lines and primary mouse hepatocytes, in vitro . Lipotoxicity was induced with palmitic acid in HepG2 cells and freshly isolated mouse hepatocytes and the cells were co-incubated with BI-3231 to assess the protective effects...
January 15, 2024: American Journal of Physiology. Cell Physiology
#16
JOURNAL ARTICLE
Samuel Young, Christian Schiffer, Alice Wagner, Jannika Patz, Anton Potapenko, Leonie Herrmann, Verena Nordhoff, Tim Pock, Claudia Krallmann, Birgit Stallmeyer, Albrecht Röpke, Michelina Kierzek, Cristina Biagioni, Tao Wang, Lars Haalck, Dirk Deuster, Jan N Hansen, Dagmar Wachten, Benjamin Risse, Hermann M Behre, Stefan Schlatt, Sabine Kliesch, Frank Tüttelmann, Christoph Brenker, Timo Strünker
The infertility of many couples rests on an enigmatic dysfunction of the man's sperm. To gain insight into the underlying pathomechanisms, we assessed the function of the sperm-specific multisubunit CatSper-channel complex in the sperm of almost 2,300 men undergoing a fertility workup, using a simple motility-based test. We identified a group of men with normal semen parameters but defective CatSper function. These men or couples failed to conceive naturally and upon medically assisted reproduction via intrauterine insemination and in vitro fertilization...
January 2, 2024: Journal of Clinical Investigation
#17
JOURNAL ARTICLE
Gabriel E Wagner, Thomas Franz Paul Stanjek, Dirk Albrecht, Michaela Lipp, Susanna J Dunachie, Esther Föderl-Höbenreich, Katharina Riedel, Anne Kohler, Ivo Steinmetz, Christian Kohler
INTRODUCTION: The environmental bacterium Burkholderia pseudomallei causes the often fatal and massively underreported infectious disease melioidosis. Antigens inducing protective immunity in experimental models have recently been identified and serodiagnostic tools have been improved. However, further elucidation of the antigenic repertoire of B. pseudomallei during human infection for diagnostic and vaccine purposes is required. The adaptation of B. pseudomallei to very different habitats is reflected by a huge genome and a selective transcriptional response to a variety of conditions...
2023: Frontiers in Immunology
#18
JOURNAL ARTICLE
Alexander Fuchs, Deliah Bockemuehl, Sabrina Jegerlehner, Christian P Both, Evelien Cools, Thomas Riva, Roland Albrecht, Robert Greif, Martin Mueller, Urs Pietsch
BACKGROUND: Out-of-hospital cardiac arrest (OHCA) in children is rare and can potentially result in severe neurological impairment. Our study aimed to identify characteristics of and factors associated with favourable neurological outcome following the resuscitation of children by the Swiss helicopter emergency medical service. MATERIALS AND METHODS: This retrospective observational study screened the Swiss Air-Ambulance electronic database from 01-01-2011 to 31-12-2021...
December 21, 2023: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
#19
JOURNAL ARTICLE
Christoph Ammer-Herrmenau, Kai L Antweiler, Thomas Asendorf, Georg Beyer, Soeren M Buchholz, Silke Cameron, Gabriele Capurso, Marko Damm, Linh Dang, Fabian Frost, Antonio Gomes, Jacob Hamm, Robert Henker, Albrecht Hoffmeister, Christian Meinhardt, Lukasz Nawacki, Vitor Nunes, Arpad Panyko, Cesareo Pardo, Veit Phillip, Aldis Pukitis, Sebastian Rasch, Diana Riekstina, Ecaterina Rinja, María Lourdes Ruiz-Rebollo, Simon Sirtl, Mark Weingarten, Vasile Sandru, Julia Woitalla, Volker Ellenrieder, Albrecht Neesse
OBJECTIVE: Early disease prediction is challenging in acute pancreatitis (AP). Here, we prospectively investigate whether the microbiome predicts severity of AP (Pancreatitis-Microbiome As Predictor of Severity; P-MAPS) early at hospital admission. DESIGN: Buccal and rectal microbial swabs were collected from 424 patients with AP within 72 hours of hospital admission in 15 European centres. All samples were sequenced by full-length 16S rRNA and metagenomic sequencing using Oxford Nanopore Technologies...
February 23, 2024: Gut
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JOURNAL ARTICLE
Nicolai Kallscheuer, Carmen E Wurzbacher, Ruth A Schmitz, Christian Jogler
Recent sampling and strain isolation campaigns have accelerated research on the bacterial phylum Planctomycetota. The contribution of more than 100 novel isolates to the open collection of currently 123 described planctomycetal species in the last decade benefited greatly from pioneering work conducted in the second half of the last century. One of those pioneers was Heinz Schlesner, who investigated budding and prosthecate bacteria from habitats world-wide during his time at Christian-Albrechts-University Kiel...
December 12, 2023: Systematic and Applied Microbiology
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