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Christiane albrecht

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https://www.readbyqxmd.com/read/28238998/factors-associated-with-contraceptive-use-among-women-of-reproductive-age-in-rural-districts-of-burkina-faso
#1
Joseph K Wulifan, Jacob Mazalale, Albrecht Jahn, Hervé Hien, Patrick Christian Ilboudo, Nicolas Meda, Paul Jacob Robyn, Saidou Hamadou, Ousmane Haidara, Manuela De Allegri
Given the current low contraceptive use and corresponding high levels of unwanted pregnancies leading to induced abortions and poor maternal health outcomes among rural populations, a detailed understanding of the factors that limit contraceptive use is essential. Our study investigated household and health facility factors that influence contraceptive use decisions among rural women in rural Burkina Faso. We collected data on fertile non-pregnant women in 24 rural districts in 2014. Of 8,657 women, 1,098 used a modern contraceptive...
2017: Journal of Health Care for the Poor and Underserved
https://www.readbyqxmd.com/read/28223354/il-1%C3%AE-induced-and-p38-mapk-dependent-activation-of-the-mitogen-activated-protein-kinase-mapk-activated-protein-kinase-mk-2-in-hepatocytes-signal-transduction-with-robust-and-concentration-independent-signal-amplification
#2
Andreas Kulawik, Raphael Engesser, Christian Ehlting, Andreas Raue, Ute Albrecht, Bettina Hahn, Wolf-Dieter Lehmann, Matthias Gaestel, Ursula Klingmüller, Dieter Häussinger, Jens Timmer, Johannes G Bode
The Interleukin (IL)-1β induced activation of the p38(MAPK)/MK2 pathway in hepatocytes is important for the control of acute phase response and regulation of liver regeneration. Many aspects of regulatory relevance of this pathway have been investigated in immune cells in the context of inflammation. However, very little is known about concentration-dependent activation kinetics and signal propagation in hepatocytes and the role of MK2. We established a mathematical model for IL-1β induced activation of the p38(MAPK)/MK2 pathway in hepatocytes that was calibrated to quantitative data on time- and IL-1β concentration-dependent phosphorylation of p38(MAPK) and MK2 in primary mouse hepatocytes...
February 21, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28205573/extracellular-protonation-modulates-cell-cell-interaction-mechanics-and-tissue-invasion-in-human-melanoma-cells
#3
Verena Hofschröer, Kevin Alexander Koch, Florian Timo Ludwig, Peter Friedl, Hans Oberleithner, Christian Stock, Albrecht Schwab
Detachment of cells from the primary tumour precedes metastatic progression by facilitating cell release into the tissue. Solid tumours exhibit altered pH homeostasis with extracellular acidification. In human melanoma, the Na(+)/H(+) exchanger NHE1 is an important modifier of the tumour nanoenvironment. Here we tested the modulation of cell-cell-adhesion by extracellular pH and NHE1. MV3 tumour spheroids embedded in a collagen matrix unravelled the efficacy of cell-cell contact loosening and 3D emigration into an environment mimicking physiological confinement...
February 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28192388/degradable-starch-microspheres-transcatheter-arterial-chemoembolization-dsm-tace-in-intrahepatic-cholangiocellular-carcinoma-icc-results-from-a-national-multi-center-study-on-safety-and-efficacy
#4
Andreas Schicho, Philippe L Pereira, Manfred Pützler, Katharina Michalik, Thomas Albrecht, Claus Nolte-Ernsting, Christian Stroszczynski, Philipp Wiggermann
BACKGROUND The aim of this study was to evaluate the safety and efficacy of DSM (degradable starch microspheres) as an embolic agent in transarterial chemoembolization in the treatment of intrahepatic cholangiocellular carcinoma (ICC). MATERIAL AND METHODS This was a national, multi-center observational cohort study on the safety and efficacy of DSM-TACE using mitomycin, gemcitabine, cisplatin, doxorubicin, and carboplatin in palliative treatment of ICC. Recruitment period for the study was from January 2010 to June 2014...
February 13, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28187543/new-data-on-the-taxonomy-ecology-and-conservation-of-the-rediscovered-i-louisea-i-i-edeaensis-i-bott-1969-brachyura-potamoidea-potamonautidae-an-endangered-freshwater-crab-from-cameroon
#5
Pierre A Mvogo Ndongo, Thomas VON Rintelen, Christoph D Schubart, Christian Albrecht, Joseph L Tamesse, Neil Cumberlidge
The rare and endangered Cameroonian potamonautid freshwater crab Louisea edeaensis (Bott, 1969) was recently rediscovered during a biological inventory of the freshwater decapods of southern Cameroon. The previous record dated back more than 100 years. The new specimens allow an updated diagnosis of the species based on comparisons of important taxonomic characters. Photographs of the carapace, gonopods, third maxillipeds, and chelipeds of the largest adult male specimen from Lake Ossa, Cameroon are provided, as are the first photographs of living specimens...
February 9, 2017: Zootaxa
https://www.readbyqxmd.com/read/28171827/vascular-inflammation-and-media-calcification-are-already-present-in-early-stages-of-chronic-kidney-disease
#6
Kerstin Benz, Ildiko Varga, Daniel Neureiter, Valentina Campean, Christoph Daniel, Christian Heim, Albrecht Reimann, Michael Weyand, Karl F Hilgers, Kerstin Amann
BACKGROUND: While patients with chronic kidney disease (CKD) have a high prevalence of classical coronary risk factors, there is increasing evidence that atherosclerosis is different in renal compared to nonrenal patients. Therefore, the present study compares changes in different vessels obtained at cardiac surgery between patients with early and advanced CKD and nonrenal control patients. METHODS AND RESULTS: Fifty patients undergoing cardiac bypass surgery were divided into three groups: (i) 24 control patients with creatinine <1...
January 23, 2017: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/28167508/hypoxia-causes-down-regulation-of-dicer-in-hepatocellular-carcinoma-which-is-required-for-up-regulation-of-hypoxia-inducible-factor-1%C3%AE-and-epithelial-mesenchymal-transition
#7
Ahmed Atef Ibrahim, Christian Schmithals, Eric Kowarz, Verena Köberle, Bianca Kakoschky, Thomas Pleli, Otto Kollmar, Scarlett Nitsch, Oliver Waidmann, Fabian Finkelmeier, Stefan Zeuzem, Horst-Werner Korf, Tobias Schmid, Andreas Weigert, Bernd Kronenberger, Rolf Marschalek, Albrecht Piiper
PURPOSE: A role of Dicer, which converts precursor miRNAs to mature miRNAs, in the tumor-promoting effect of hypoxia is currently emerging in some tumor entities. Its role in hepatocellular carcinoma (HCC) is unknown. EXPERIMENTAL DESIGN: HepG2 and Huh-7 cells were stably transfected with an inducible Dicer expression vector and were exposed to hypoxia/normoxia. HepG2-Dicer xenografts were established in nude mice; hypoxic areas and Dicer were detected in HCC xenografts and HCCs from mice with endogenous hepatocarcinogenesis; epithelial mesenchymal transition (EMT) markers were analyzed by immunohistochemistry or by immunoblotting...
February 6, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28165722/green-synthesis-of-zr-cau-28-structure-and-properties-of-the-first-zr-mof-based-on-2-5-furandicarboxylic-acid
#8
Anna C Dreischarf, Martin Lammert, Norbert Stock, Helge Reinsch
A new Zr-based metal-organic framework denoted as Zr-CAU-28 with framework composition [Zr6O4(OH)4(FDC)4(OH)4(H2O)4] (H2FDC = 2,5-furandicarboxylic acid, CAU = Christian-Albrechts-University) was obtained under green synthesis conditions from a mixture of H2O and acetic acid and employing microwave-assisted heating. Zr-CAU-28 is the first Zr-MOF based on H2FDC, which is often considered a promising renewable alternative to terephthalic acid. The crystal structure was determined from powder X-ray diffraction data using a combination of direct methods, force field calculations, and Rietveld refinement...
February 20, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28139285/guided-modern-endodontic-surgery-a-novel-approach-for-guided-osteotomy-and-root-resection
#9
Georg D Strbac, Albrecht Schnappauf, Katharina Giannis, Andreas Moritz, Christian Ulm
INTRODUCTION: Continuous improvements in techniques, instruments, and materials have established modern endodontic microsurgery as a state-of-the-art treatment method. The purpose of this approach was to introduce a new surgical endodontic technique by using a three-dimensional printed template for guided osteotomy and root resection. METHODS: A 38-year-old patient was diagnosed with periapical lesions of teeth #3 and #4 and extruded gutta-percha material. Three-dimensional radiographic and optical scan files were imported into surgical planning software designed for guided implant surgery...
March 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28134094/outcome-after-long-segment-stenting-with-everolimus-eluting-bioresorbable-scaffolds-focusing-on-the-concept-of-overlapping-implantation
#10
Jens Wiebe, Oliver Dörr, Christoph Liebetrau, Timm Bauer, Eva Wilkens, Hanna Ilstad, Niklas Boeder, Albrecht Elsässer, Helge Möllmann, Christian W Hamm, Holger M Nef
INTRODUCTION AND OBJECTIVES: The implantation of bioresorbable scaffolds (BRS) is an emerging technique used in percutaneous coronary interventions. Their application has been extended to more complex lesions, although evidence is only available for simple lesions. The present study evaluated scaffold implantation in long lesions, focusing on overlapping scaffolds. METHODS: We retrospectively analyzed all consecutive patients eligible for stenting with everolimus-eluting poly-L-lactic acid-based BRS with a minimum total scaffold length of 28mm, irrespective of the number of BRS used...
December 2016: Revista Española de Cardiología
https://www.readbyqxmd.com/read/28119329/marker-chromosomes-can-arise-from-chromothripsis-and-predict-adverse-prognosis-in-acute-myeloid-leukemia
#11
Tilmann Bochtler, Martin Granzow, Friedrich Stölzel, Christina Kunz, Brigitte Mohr, Mutlu Kartal-Kaess, Katrin Hinderhofer, Christoph E Heilig, Michael Kramer, Christian Thiede, Volker Endris, Martina Kirchner, Albrecht Stenzinger, Axel Benner, Martin Bornhäuser, Gerhard Ehninger, Anthony D Ho, Anna Jauch, Alwin Krämer
Metaphase karyotyping is an established diagnostic standard in acute myeloid leukemia (AML) for risk stratification. One of the cytogenetic findings in AML are structurally highly abnormal marker chromosomes. In this study we have assessed frequency, cytogenetic characteristics, prognostic impact and underlying biological origin of marker chromosomes. Given their inherent gross structural chromosomal damage, we speculated that they may arise from chromothripsis, a recently described phenomenon of chromosome fragmentation in a single catastrophic event...
January 24, 2017: Blood
https://www.readbyqxmd.com/read/28118075/dietary-spermidine-for-lowering-high-blood-pressure
#12
Tobias Eisenberg, Mahmoud Abdellatif, Andreas Zimmermann, Sabrina Schroeder, Tobias Pendl, Alexandra Harger, Slaven Stekovic, Julia Schipke, Christoph Magnes, Albrecht Schmidt, Christoph Ruckenstuhl, Christopher Dammbrueck, Angelina S Gross, Viktoria Herbst, Didac Carmona-Gutierrez, Federico Pietrocola, Thomas R Pieber, Stephan J Sigrist, Wolfgang A Linke, Christian Mühlfeld, Junichi Sadoshima, Joern Dengjel, Stefan Kiechl, Guido Kroemer, Simon Sedej, Frank Madeo
Loss of cardiac macroautophagy/autophagy impairs heart function, and evidence accumulates that an increased autophagic flux may protect against cardiovascular disease. We therefore tested the protective capacity of the natural autophagy inducer spermidine in animal models of aging and hypertension, which both represent major risk factors for the development of cardiovascular disease. Dietary spermidine elicits cardioprotective effects in aged mice through enhancing cardiac autophagy and mitophagy. In salt-sensitive rats, spermidine supplementation also delays the development of hypertensive heart disease, coinciding with reduced arterial blood pressure...
January 24, 2017: Autophagy
https://www.readbyqxmd.com/read/28108031/ifpa-meeting-2016-workshop-report-i-genomic-communication-bioinformatics-trophoblast-biology-and-transport-systems
#13
Christiane Albrecht, Julie C Baker, Cassidy Blundell, Shawn L Chavez, Lucia Carbone, Larry Chamley, Roberta L Hannibal, Nick Illsley, Peter Kurre, Louise C Laurent, Charles McKenzie, Diana Morales-Prieto, Priyadarshini Pantham, Alison Paquette, Katie Powell, Nathan Price, Balaji M Rao, Yoel Sadovsky, Carlos Salomon, Geetu Tuteja, Samantha Wilson, P F O'Tierney-Ginn
Workshops are an important part of the IFPA annual meeting as they allow for discussion of specialized topics. At IFPA meeting 2016 there were twelve themed workshops, four of which are summarized in this report. These workshops covered innovative technologies applied to new and traditional areas of placental research: 1) genomic communication; 2) bioinformatics; 3) trophoblast biology and pathology; 4) placental transport systems.
January 11, 2017: Placenta
https://www.readbyqxmd.com/read/28078447/trends-in-aortic-valve-replacement-in-germany-in-2015-transcatheter-versus-isolated-surgical-aortic-valve-repair
#14
Luise Gaede, Johannes Blumenstein, Won-Keun Kim, Christoph Liebetrau, Oliver Dörr, Holger Nef, Christian Hamm, Albrecht Elsässer, Helge Möllmann
AIMS: We analysed the number of procedures, indications, and in-hospital mortality rates of all patients undergoing isolated surgical aortic valve replacement (sAVR) or transvascular (TV-) and transapical (TA-) transcatheter aortic valve implantation (TAVI) from 2012 to 2015 in Germany. METHODS AND RESULTS: More than 31,000 aortic valve procedures were performed in 2015 in Germany, representing a total increase of 4.5% over 2014. TV-TAVI accounts for 13,108 of these procedures, with an increase of 21%, whereas the numbers of isolated sAVR and TA-TAVI decreased slightly...
January 11, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28045490/an-allosteric-inhibitor-scaffold-targeting-the-pif-pocket-of-atypical-protein-kinase-c-isoforms
#15
Jose M Arencibia, Wolfgang Fröhner, Magdalena Krupa, Daniel Pastor-Flores, Piotr Merker, Thomas Oellerich, Sonja Neimanis, Christian Schmithals, Verena Köberle, Evelyn Süß, Stefan Zeuzem, Holger Stark, Albrecht Piiper, Dalibor Odadzic, Jörg O Schulze, Ricardo M Biondi
There is a current and pressing need for improved cancer therapies. The use of small molecule kinase inhibitors and their application in combinatorial regimens represent an approach to personalized targeted cancer therapy. A number of AGC kinases, including atypical Protein Kinase C enzymes (PKCs), are validated drug targets for cancer treatment. Most drug development programs for protein kinases focus on the development of drugs that bind at the ATP-binding site. Alternatively, allosteric drugs have great potential for the development of future innovative drugs...
January 13, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28024654/coronary-computed-tomography-angiography-derived-plaque-quantification-in-patients-with-acute-coronary%C3%A2-syndrome
#16
Christian Tesche, Damiano Caruso, Carlo N De Cecco, Darby C Shuler, Jess D Rames, Moritz H Albrecht, Taylor M Duguay, Akos Varga-Szemes, David Jochheim, Moritz Baquet, Richard R Bayer, Ullrich Ebersberger, Sheldon E Litwin, Salvatore A Chiaramida, Ellen Hoffmann, U Joseph Schoepf
This study investigated the discriminatory value of quantitative atherosclerotic plaque markers derived from coronary computed tomography angiography (cCTA) in patients with first acute coronary syndrome (ACS) compared with patients with stable coronary artery disease (CAD). Forty patients (56.9 ± 9.3 years, 55% men) admitted with their first ACS and Framingham risk score-matched controls with stable CAD were retrospectively analyzed. All patients had undergone cCTA followed by invasive coronary angiography...
December 3, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/28008919/ecological-networks-are-more-sensitive-to-plant-than-to-animal-extinction-under-climate-change
#17
Matthias Schleuning, Jochen Fründ, Oliver Schweiger, Erik Welk, Jörg Albrecht, Matthias Albrecht, Marion Beil, Gita Benadi, Nico Blüthgen, Helge Bruelheide, Katrin Böhning-Gaese, D Matthias Dehling, Carsten F Dormann, Nina Exeler, Nina Farwig, Alexander Harpke, Thomas Hickler, Anselm Kratochwil, Michael Kuhlmann, Ingolf Kühn, Denis Michez, Sonja Mudri-Stojnić, Michaela Plein, Pierre Rasmont, Angelika Schwabe, Josef Settele, Ante Vujić, Christiane N Weiner, Martin Wiemers, Christian Hof
Impacts of climate change on individual species are increasingly well documented, but we lack understanding of how these effects propagate through ecological communities. Here we combine species distribution models with ecological network analyses to test potential impacts of climate change on >700 plant and animal species in pollination and seed-dispersal networks from central Europe. We discover that animal species that interact with a low diversity of plant species have narrow climatic niches and are most vulnerable to climate change...
December 23, 2016: Nature Communications
https://www.readbyqxmd.com/read/27989269/dietary-tryptophan-depletion-in-humans-using-a-simplified-two-amino-acid-formula-a-pilot-study
#18
Maike Linden, Katrin Helmbold, Janina Kempf, Shabnam Sippas, Christian Filss, Karl-Josef Langen, Albrecht Eisert, Florian Daniel Zepf
BACKGROUND: Acute tryptophan depletion (ATD) is a well-established dietary method in translational brain research used to briefly lower central nervous serotonin (5-hydroxytryptamine (5-HT)) synthesis. A simplified two amino acid ATD formula (ATDPHE/LEU) was developed while reducing the overall amount of amino acids (AAs), with the objective of administration especially in children and adolescents in future studies. OBJECTIVE: This study investigated tryptophan (TRP) influx rates across the blood-brain barrier (BBB) after dietary ATDPHE/LEU administration relative to the ATD Moja-De protocol that has been established for use in children and adolescents...
2016: Food & Nutrition Research
https://www.readbyqxmd.com/read/27986496/medical-diagnostics-for-indoor-mold-exposure
#19
REVIEW
Julia Hurraß, Birger Heinzow, Ute Aurbach, Karl-Christian Bergmann, Albrecht Bufe, Walter Buzina, Oliver A Cornely, Steffen Engelhart, Guido Fischer, Thomas Gabrio, Werner Heinz, Caroline E W Herr, Jörg Kleine-Tebbe, Ludger Klimek, Martin Köberle, Herbert Lichtnecker, Thomas Lob-Corzilius, Rolf Merget, Norbert Mülleneisen, Dennis Nowak, Uta Rabe, Monika Raulf, Hans Peter Seidl, Jens-Oliver Steiß, Regine Szewszyk, Peter Thomas, Kerttu Valtanen, Gerhard A Wiesmüller
In April 2016, the German Society of Hygiene, Environmental Medicine and Preventative Medicine (Gesellschaft für Hygiene, Umweltmedizin und Präventivmedizin (GHUP)) together with other scientific medical societies, German and Austrian medical societies, physician unions and experts has provided an AWMF (Association of the Scientific Medical Societies) guideline 'Medical diagnostics for indoor mold exposure'. This guideline shall help physicians to advise and treat patients exposed indoors to mold. Indoor mold growth is a potential health risk, even without a quantitative and/or causal association between the occurrence of individual mold species and health effects...
December 5, 2016: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/27986261/accuracy-and-radiation-dose-reduction-using-low-voltage-computed-tomography-coronary-artery-calcium-scoring-with-tin-filtration
#20
Christian Tesche, Carlo N De Cecco, Rozemarijn Vliegenthart, Moritz H Albrecht, Akos Varga-Szemes, Taylor M Duguay, Ullrich Ebersberger, Richard R Bayer, Christian Canstein, Bernhard Schmidt, Thomas Allmendinger, Sheldon E Litwin, Pamela B Morris, Thomas G Flohr, Ellen Hoffmann, U Joseph Schoepf
This study prospectively investigated the accuracy and radiation dose reduction of CT coronary artery calcium scoring (CACS) using a 100 kVp acquisition protocol with tin filtration (Sn100 kVp) compared with the standard 120 kVp acquisition protocol; 70 patients (59% men, 62.1 ± 10.7 years) who underwent a clinically indicated CACS acquisition using the standard 120 kVp protocol on a third-generation dual-source CT system were enrolled. An additional Sn100 kVp CACS scan was performed. Agatston scores and categories, percentile-based risk categorization, and radiation dose estimates were derived from 120 and Sn100 kVp studies and compared...
February 15, 2017: American Journal of Cardiology
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