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Christiane albrecht

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https://www.readbyqxmd.com/read/28408873/neurofeedback-of-slow-cortical-potentials-in-children-with-attention-deficit-hyperactivity-disorder-a-multicenter-randomized-trial-controlling-for-unspecific-effects
#1
Ute Strehl, Pascal Aggensteiner, Daniel Wachtlin, Daniel Brandeis, Björn Albrecht, Maria Arana, Christiane Bach, Tobias Banaschewski, Thorsten Bogen, Andrea Flaig-Röhr, Christine M Freitag, Yvonne Fuchsenberger, Stephanie Gest, Holger Gevensleben, Laura Herde, Sarah Hohmann, Tanja Legenbauer, Anna-Maria Marx, Sabina Millenet, Benjamin Pniewski, Aribert Rothenberger, Christian Ruckes, Sonja Wörz, Martin Holtmann
Background: Neurofeedback (NF) in children with attention-deficit/hyperactivity disorder (ADHD) has been investigated in a series of studies over the last years. Previous studies did not unanimously support NF as a treatment in ADHD. Most studies did not control for unspecific treatment effects and did not demonstrate that self-regulation took place. The present study examined the efficacy of NF in comparison to electromyographic (EMG) feedback to control for unspecific effects of the treatment, and assessed self-regulation of slow cortical potentials (SCPs)...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28404863/individuals-with-progranulin-haploinsufficiency-exhibit-features-of-neuronal-ceroid-lipofuscinosis
#2
Michael E Ward, Robert Chen, Hsin-Yi Huang, Connor Ludwig, Maria Telpoukhovskaia, Ali Taubes, Helene Boudin, Sakura S Minami, Meredith Reichert, Philipp Albrecht, Jeffrey M Gelfand, Andres Cruz-Herranz, Christian Cordano, Marcel V Alavi, Shannon Leslie, William W Seeley, Bruce L Miller, Eileen Bigio, Marek-Marsel Mesulam, Matthew S Bogyo, Ian R Mackenzie, John F Staropoli, Susan L Cotman, Eric J Huang, Li Gan, Ari J Green
Heterozygous mutations in the GRN gene lead to progranulin (PGRN) haploinsufficiency and cause frontotemporal dementia (FTD), a neurodegenerative syndrome of older adults. Homozygous GRN mutations, on the other hand, lead to complete PGRN loss and cause neuronal ceroid lipofuscinosis (NCL), a lysosomal storage disease usually seen in children. Given that the predominant clinical and pathological features of FTD and NCL are distinct, it is controversial whether the disease mechanisms associated with complete and partial PGRN loss are similar or distinct...
April 12, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28403175/altered-cortical-and-subcortical-connectivity-due-to-infrasound-administered-near-the-hearing-threshold-evidence-from-fmri
#3
Markus Weichenberger, Martin Bauer, Robert Kühler, Johannes Hensel, Caroline Garcia Forlim, Albrecht Ihlenfeld, Bernd Ittermann, Jürgen Gallinat, Christian Koch, Simone Kühn
In the present study, the brain's response towards near- and supra-threshold infrasound (IS) stimulation (sound frequency < 20 Hz) was investigated under resting-state fMRI conditions. The study involved two consecutive sessions. In the first session, 14 healthy participants underwent a hearing threshold-as well as a categorical loudness scaling measurement in which the individual loudness perception for IS was assessed across different sound pressure levels (SPL). In the second session, these participants underwent three resting-state acquisitions, one without auditory stimulation (no-tone), one with a monaurally presented 12-Hz IS tone (near-threshold) and one with a similar tone above the individual hearing threshold corresponding to a 'medium loud' hearing sensation (supra-threshold)...
2017: PloS One
https://www.readbyqxmd.com/read/28332927/leptospira-spp-in-small-mammals-from-areas-with-low-and-high-human-hantavirus-incidences-in-south-west-germany
#4
Anna Obiegala, Christoph Albrecht, Maysaa Dafalla, Stephan Drewes, Carolin Oltersdorf, Hendrik Turni, Christian Imholt, Jens Jacob, Christiane Wagner-Wiening, Rainer G Ulrich, Martin Pfeffer
INTRODUCTION: Leptospirosis is caused by Leptospira spp. and is considered the most widespread zoonotic disease worldwide. It mimics nephropathia epidemica in humans, a disease mainly caused by Puumala hantavirus (PUUV). Small mammals are reservoirs for Leptospira spp. and PUUV. Seewis virus (SWSV) is a shrew-borne hantavirus with unknown pathogenicity. The objective of this study was to estimate the prevalence for Leptospira spp. and the frequency of Leptospira-hantavirus co-infections in small mammals collected at locations with high and low incidences in humans...
March 23, 2017: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/28290203/symbiotic-interplay-of-fungi-algae-and-bacteria-within-the-lung-lichen-i-lobaria-pulmonaria-i-l-hoffm-as-assessed-by-i-state-of-the-art-i-metaproteomics
#5
Christine Eymann, Christian Lassek, Uwe Wegner, Jörg Bernhardt, Ole Arno Fritsch, Stephan Fuchs, Andreas Otto, Dirk Albrecht, Ulf Schiefelbein, Tomislav Cernava, Ines Aschenbrenner, Gabriele Berg, Martin Grube, Katharina Riedel
Lichens are recognized by macroscopic structures formed by a heterotrophic fungus, the mycobiont, which hosts internal autotrophic photosynthetic algal and/or cyanobacterial partners, referred to as the photobiont. We analyzed structure and functionality of the entire lung lichen </i>Lobaria pulmonaria</i> L. Hoffm. collected from two different sites by state-of-the-art metaproteomics. In addition to the green algae and the ascomycetous fungus, a lichenicolous fungus, as well as a complex prokaryotic community (different from the cyanobacteria) was found, the latter dominated by methanotrophic Rhizobiales...
March 14, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28264699/recent-range-expansion-of-an-intermediate-host-for-animal-schistosome-parasites-in-the-indo-australian-archipelago-phylogeography-of-the-freshwater-gastropod-indoplanorbis-exustus-in-south-and-southeast-asia
#6
Pauline Gauffre-Autelin, Thomas von Rintelen, Björn Stelbrink, Christian Albrecht
BACKGROUND: The planorbid snail Indoplanorbis exustus is the sole intermediate host for the Schistosoma indicum species group, trematode parasites responsible for cattle schistosomiasis and human cercarial dermatitis. This freshwater snail is widely distributed in Southern Asia, ranging from Iran to China eastwards including India and from the southeastern Himalayas to Southeast Asia southwards. The veterinary and medical importance of this snail explains the interest in understanding its geographical distribution patterns and evolutionary history...
March 6, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28238998/factors-associated-with-contraceptive-use-among-women-of-reproductive-age-in-rural-districts-of-burkina-faso
#7
Joseph K Wulifan, Jacob Mazalale, Albrecht Jahn, Hervé Hien, Patrick Christian Ilboudo, Nicolas Meda, Paul Jacob Robyn, Saidou Hamadou, Ousmane Haidara, Manuela De Allegri
Given the current low contraceptive use and corresponding high levels of unwanted pregnancies leading to induced abortions and poor maternal health outcomes among rural populations, a detailed understanding of the factors that limit contraceptive use is essential. Our study investigated household and health facility factors that influence contraceptive use decisions among rural women in rural Burkina Faso. We collected data on fertile non-pregnant women in 24 rural districts in 2014. Of 8,657 women, 1,098 used a modern contraceptive...
2017: Journal of Health Care for the Poor and Underserved
https://www.readbyqxmd.com/read/28223354/il-1%C3%AE-induced-and-p38-mapk-dependent-activation-of-the-mitogen-activated-protein-kinase-activated-protein-kinase-2-mk2-in-hepatocytes-signal-transduction-with-robust-and-concentration-independent-signal-amplification
#8
Andreas Kulawik, Raphael Engesser, Christian Ehlting, Andreas Raue, Ute Albrecht, Bettina Hahn, Wolf-Dieter Lehmann, Matthias Gaestel, Ursula Klingmüller, Dieter Häussinger, Jens Timmer, Johannes G Bode
The IL-1β induced activation of the p38(MAPK)/MAPK-activated protein kinase 2 (MK2) pathway in hepatocytes is important for control of the acute phase response and regulation of liver regeneration. Many aspects of the regulatory relevance of this pathway have been investigated in immune cells in the context of inflammation. However, very little is known about concentration-dependent activation kinetics and signal propagation in hepatocytes and the role of MK2. We established a mathematical model for IL-1β-induced activation of the p38(MAPK)/MK2 pathway in hepatocytes that was calibrated to quantitative data on time- and IL-1β concentration-dependent phosphorylation of p38(MAPK) and MK2 in primary mouse hepatocytes...
April 14, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28205573/extracellular-protonation-modulates-cell-cell-interaction-mechanics-and-tissue-invasion-in-human-melanoma-cells
#9
Verena Hofschröer, Kevin Alexander Koch, Florian Timo Ludwig, Peter Friedl, Hans Oberleithner, Christian Stock, Albrecht Schwab
Detachment of cells from the primary tumour precedes metastatic progression by facilitating cell release into the tissue. Solid tumours exhibit altered pH homeostasis with extracellular acidification. In human melanoma, the Na(+)/H(+) exchanger NHE1 is an important modifier of the tumour nanoenvironment. Here we tested the modulation of cell-cell-adhesion by extracellular pH and NHE1. MV3 tumour spheroids embedded in a collagen matrix unravelled the efficacy of cell-cell contact loosening and 3D emigration into an environment mimicking physiological confinement...
February 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28192388/degradable-starch-microspheres-transcatheter-arterial-chemoembolization-dsm-tace-in-intrahepatic-cholangiocellular-carcinoma-icc-results-from-a-national-multi-center-study-on-safety-and-efficacy
#10
Andreas Schicho, Philippe L Pereira, Manfred Pützler, Katharina Michalik, Thomas Albrecht, Claus Nolte-Ernsting, Christian Stroszczynski, Philipp Wiggermann
BACKGROUND The aim of this study was to evaluate the safety and efficacy of DSM (degradable starch microspheres) as an embolic agent in transarterial chemoembolization in the treatment of intrahepatic cholangiocellular carcinoma (ICC). MATERIAL AND METHODS This was a national, multi-center observational cohort study on the safety and efficacy of DSM-TACE using mitomycin, gemcitabine, cisplatin, doxorubicin, and carboplatin in palliative treatment of ICC. Recruitment period for the study was from January 2010 to June 2014...
February 13, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28187543/new-data-on-the-taxonomy-ecology-and-conservation-of-the-rediscovered-i-louisea-i-i-edeaensis-i-bott-1969-brachyura-potamoidea-potamonautidae-an-endangered-freshwater-crab-from-cameroon
#11
Pierre A Mvogo Ndongo, Thomas VON Rintelen, Christoph D Schubart, Christian Albrecht, Joseph L Tamesse, Neil Cumberlidge
The rare and endangered Cameroonian potamonautid freshwater crab Louisea edeaensis (Bott, 1969) was recently rediscovered during a biological inventory of the freshwater decapods of southern Cameroon. The previous record dated back more than 100 years. The new specimens allow an updated diagnosis of the species based on comparisons of important taxonomic characters. Photographs of the carapace, gonopods, third maxillipeds, and chelipeds of the largest adult male specimen from Lake Ossa, Cameroon are provided, as are the first photographs of living specimens...
February 9, 2017: Zootaxa
https://www.readbyqxmd.com/read/28171827/vascular-inflammation-and-media-calcification-are-already-present-in-early-stages-of-chronic-kidney-disease
#12
Kerstin Benz, Ildiko Varga, Daniel Neureiter, Valentina Campean, Christoph Daniel, Christian Heim, Albrecht Reimann, Michael Weyand, Karl F Hilgers, Kerstin Amann
BACKGROUND: While patients with chronic kidney disease (CKD) have a high prevalence of classical coronary risk factors, there is increasing evidence that atherosclerosis is different in renal compared to nonrenal patients. Therefore, the present study compares changes in different vessels obtained at cardiac surgery between patients with early and advanced CKD and nonrenal control patients. METHODS AND RESULTS: Fifty patients undergoing cardiac bypass surgery were divided into three groups: (i) 24 control patients with creatinine <1...
March 2017: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/28167508/hypoxia-causes-down-regulation-of-dicer-in-hepatocellular-carcinoma-which-is-required-for-up-regulation-of-hypoxia-inducible-factor-1%C3%AE-and-epithelial-mesenchymal-transition
#13
Ahmed Atef Ibrahim, Christian Schmithals, Eric Kowarz, Verena Köberle, Bianca Kakoschky, Thomas Pleli, Otto Kollmar, Scarlett Nitsch, Oliver Waidmann, Fabian Finkelmeier, Stefan Zeuzem, Horst-Werner Korf, Tobias Schmid, Andreas Weigert, Bernd Kronenberger, Rolf Marschalek, Albrecht Piiper
PURPOSE: A role of Dicer, which converts precursor miRNAs to mature miRNAs, in the tumor-promoting effect of hypoxia is currently emerging in some tumor entities. Its role in hepatocellular carcinoma (HCC) is unknown. EXPERIMENTAL DESIGN: HepG2 and Huh-7 cells were stably transfected with an inducible Dicer expression vector and were exposed to hypoxia/normoxia. HepG2-Dicer xenografts were established in nude mice; hypoxic areas and Dicer were detected in HCC xenografts and HCCs from mice with endogenous hepatocarcinogenesis; epithelial mesenchymal transition (EMT) markers were analyzed by immunohistochemistry or by immunoblotting...
February 6, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28165722/green-synthesis-of-zr-cau-28-structure-and-properties-of-the-first-zr-mof-based-on-2-5-furandicarboxylic-acid
#14
Anna C Dreischarf, Martin Lammert, Norbert Stock, Helge Reinsch
A new Zr-based metal-organic framework denoted as Zr-CAU-28 with framework composition [Zr6O4(OH)4(FDC)4(OH)4(H2O)4] (H2FDC = 2,5-furandicarboxylic acid, CAU = Christian-Albrechts-University) was obtained under green synthesis conditions from a mixture of H2O and acetic acid and employing microwave-assisted heating. Zr-CAU-28 is the first Zr-MOF based on H2FDC, which is often considered a promising renewable alternative to terephthalic acid. The crystal structure was determined from powder X-ray diffraction data using a combination of direct methods, force field calculations, and Rietveld refinement...
February 20, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28139285/guided-modern-endodontic-surgery-a-novel-approach-for-guided-osteotomy-and-root-resection
#15
Georg D Strbac, Albrecht Schnappauf, Katharina Giannis, Andreas Moritz, Christian Ulm
INTRODUCTION: Continuous improvements in techniques, instruments, and materials have established modern endodontic microsurgery as a state-of-the-art treatment method. The purpose of this approach was to introduce a new surgical endodontic technique by using a three-dimensional printed template for guided osteotomy and root resection. METHODS: A 38-year-old patient was diagnosed with periapical lesions of teeth #3 and #4 and extruded gutta-percha material. Three-dimensional radiographic and optical scan files were imported into surgical planning software designed for guided implant surgery...
March 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28134094/outcome-after-long-segment-stenting-with-everolimus-eluting-bioresorbable-scaffolds-focusing-on-the-concept-of-overlapping-implantation
#16
Jens Wiebe, Oliver Dörr, Christoph Liebetrau, Timm Bauer, Eva Wilkens, Hanna Ilstad, Niklas Boeder, Albrecht Elsässer, Helge Möllmann, Christian W Hamm, Holger M Nef
INTRODUCTION AND OBJECTIVES: The implantation of bioresorbable scaffolds (BRS) is an emerging technique used in percutaneous coronary interventions. Their application has been extended to more complex lesions, although evidence is only available for simple lesions. The present study evaluated scaffold implantation in long lesions, focusing on overlapping scaffolds. METHODS: We retrospectively analyzed all consecutive patients eligible for stenting with everolimus-eluting poly-L-lactic acid-based BRS with a minimum total scaffold length of 28mm, irrespective of the number of BRS used...
December 2016: Revista Española de Cardiología
https://www.readbyqxmd.com/read/28119329/marker-chromosomes-can-arise-from-chromothripsis-and-predict-adverse-prognosis-in-acute-myeloid-leukemia
#17
Tilmann Bochtler, Martin Granzow, Friedrich Stölzel, Christina Kunz, Brigitte Mohr, Mutlu Kartal-Kaess, Katrin Hinderhofer, Christoph E Heilig, Michael Kramer, Christian Thiede, Volker Endris, Martina Kirchner, Albrecht Stenzinger, Axel Benner, Martin Bornhäuser, Gerhard Ehninger, Anthony D Ho, Anna Jauch, Alwin Krämer
Metaphase karyotyping is an established diagnostic standard in acute myeloid leukemia (AML) for risk stratification. One of the cytogenetic findings in AML is structurally highly abnormal marker chromosomes. In this study, we have assessed frequency, cytogenetic characteristics, prognostic impact, and underlying biological origin of marker chromosomes. Given their inherent gross structural chromosomal damage, we speculated that they may arise from chromothripsis, a recently described phenomenon of chromosome fragmentation in a single catastrophic event...
March 9, 2017: Blood
https://www.readbyqxmd.com/read/28118075/dietary-spermidine-for-lowering-high-blood-pressure
#18
Tobias Eisenberg, Mahmoud Abdellatif, Andreas Zimmermann, Sabrina Schroeder, Tobias Pendl, Alexandra Harger, Slaven Stekovic, Julia Schipke, Christoph Magnes, Albrecht Schmidt, Christoph Ruckenstuhl, Christopher Dammbrueck, Angelina S Gross, Viktoria Herbst, Didac Carmona-Gutierrez, Federico Pietrocola, Thomas R Pieber, Stephan J Sigrist, Wolfgang A Linke, Christian Mühlfeld, Junichi Sadoshima, Joern Dengjel, Stefan Kiechl, Guido Kroemer, Simon Sedej, Frank Madeo
Loss of cardiac macroautophagy/autophagy impairs heart function, and evidence accumulates that an increased autophagic flux may protect against cardiovascular disease. We therefore tested the protective capacity of the natural autophagy inducer spermidine in animal models of aging and hypertension, which both represent major risk factors for the development of cardiovascular disease. Dietary spermidine elicits cardioprotective effects in aged mice through enhancing cardiac autophagy and mitophagy. In salt-sensitive rats, spermidine supplementation also delays the development of hypertensive heart disease, coinciding with reduced arterial blood pressure...
April 3, 2017: Autophagy
https://www.readbyqxmd.com/read/28108031/ifpa-meeting-2016-workshop-report-i-genomic-communication-bioinformatics-trophoblast-biology-and-transport-systems
#19
Christiane Albrecht, Julie C Baker, Cassidy Blundell, Shawn L Chavez, Lucia Carbone, Larry Chamley, Roberta L Hannibal, Nick Illsley, Peter Kurre, Louise C Laurent, Charles McKenzie, Diana Morales-Prieto, Priyadarshini Pantham, Alison Paquette, Katie Powell, Nathan Price, Balaji M Rao, Yoel Sadovsky, Carlos Salomon, Geetu Tuteja, Samantha Wilson, P F O'Tierney-Ginn
Workshops are an important part of the IFPA annual meeting as they allow for discussion of specialized topics. At IFPA meeting 2016 there were twelve themed workshops, four of which are summarized in this report. These workshops covered innovative technologies applied to new and traditional areas of placental research: 1) genomic communication; 2) bioinformatics; 3) trophoblast biology and pathology; 4) placental transport systems.
January 11, 2017: Placenta
https://www.readbyqxmd.com/read/28078447/trends-in-aortic-valve-replacement-in-germany-in-2015-transcatheter-versus-isolated-surgical-aortic-valve-repair
#20
Luise Gaede, Johannes Blumenstein, Won-Keun Kim, Christoph Liebetrau, Oliver Dörr, Holger Nef, Christian Hamm, Albrecht Elsässer, Helge Möllmann
AIMS: We analysed the number of procedures, indications, and in-hospital mortality rates of all patients undergoing isolated surgical aortic valve replacement (sAVR) or transvascular (TV-) and transapical (TA-) transcatheter aortic valve implantation (TAVI) from 2012 to 2015 in Germany. METHODS AND RESULTS: More than 31,000 aortic valve procedures were performed in 2015 in Germany, representing a total increase of 4.5% over 2014. TV-TAVI accounts for 13,108 of these procedures, with an increase of 21%, whereas the numbers of isolated sAVR and TA-TAVI decreased slightly...
January 11, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
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