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Christiane albrecht

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https://www.readbyqxmd.com/read/29322445/northern-blot-analysis-of-circular-rnas
#1
Tim Schneider, Silke Schreiner, Christian Preußer, Albrecht Bindereif, Oliver Rossbach
Northern blotting enables the specific detection and characterization of RNA molecules. Recently, circular RNAs (circRNAs) were described as a new class of cell type-specific noncoding RNAs. With the discovery of many novel circRNAs on the basis of high-throughput sequencing and bioinformatics, a solid biochemical approach is required to directly detect and validate specific circRNA species. Here we give a detailed overview of how different Northern blot methods can be employed to validate specific circRNAs...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29298872/acute-sedation-associated-complications-in-gi-endoscopy-prosed-2-study-results-from-the-prospective-multicentre-electronic-registry-of-sedation-associated-complications
#2
Angelika Behrens, Anton Kreuzmayr, Hendrik Manner, Herbert Koop, Albrecht Lorenz, Claus Schaefer, Mathais Plauth, Jens-Uwe Jetschmann, Christian von Tirpitz, Marcus Ewald, Michael Sackmann, Wanja Renner, Martin Krüger, Dieter Schwab, Werner Hoffmann, Olaf Engelke, Oliver Pech, Frank Kullmann, Sonja Pampuch, Berthold Lenfers, Uwe Weickert, Dieter Schilling, Stephan Boehm, Susanne Beckebaum, Vito Cicinnati, Joachim F Erckenbrecht, Franz Ludwig Dumoulin, Claus Benz, Thomas Rabenstein, Georg Haltern, Martin Balsliemke, Christian de Mas, Gerhard Kleber, Christian Pehl, Christoph Vogt, Ralf Kiesslich, Wolfgang Fischbach, Irmtraut Koop, Jens Kuehne, Matthias Breidert, Nils Lennart Sass, Andrea May, Christian Friedrich, Ronni Veitt, Rainer Porschen, Mark Ellrichmann, Alexander Arlt, Wolfgang Schmitt, Markus Dollhopf, Werner Schmidbaur, Axel Dignass, Volker Schmitz, J Labenz, Gernot Kaiser, Alexander Krannich, Nico Barteska, Christian Ell
OBJECTIVES: Sedation has been established for GI endoscopic procedures in most countries, but it is also associated with an added risk of complications. Reported complication rates are variable due to different study methodologies and often limited sample size. DESIGNS: Acute sedation-associated complications were prospectively recorded in an electronic endoscopy documentation in 39 study centres between December 2011 and August 2014 (median inclusion period 24 months)...
January 3, 2018: Gut
https://www.readbyqxmd.com/read/29296832/a-unique-microenvironment-in-the-developing-liver-supports-the-expansion-of-megakaryocyte-progenitors
#3
Nathalie Brouard, Camille Jost, Nadine Matthias, Camille Albrecht, Sébastien Egard, Poojabahen Gandhi, Catherine Strassel, Tomoko Inoue, Daisuke Sugiyama, Paul J Simmons, Christian Gachet, Francois Lanza
The fetal liver is the site of a major expansion of the hematopoietic stem cell (HSC) pool and is also a privileged organ to study megakaryocyte progenitor differentiation. We identified in the mouse fetal liver at day 13.5 a discrete stromal cell population harboring a CD45-TER119-CD31-CD51+VCAM-1+PDGFRα- (V+P-) phenotype that lacked colony-forming unit fibroblast activity and harbored an hepatocyte progenitor signature. This previously undescribed V+P- population efficiently supported megakaryocyte production from mouse bone marrow HSC and human peripheral blood HSC-myeloid progenitors cultured in the presence of limited cytokine concentrations...
September 26, 2017: Blood Advances
https://www.readbyqxmd.com/read/29279799/prediction-of-30-day-mortality-in-spontaneous-cerebellar-hemorrhage
#4
Diaa Al Safatli, Albrecht Guenther, Aaron Lawson McLean, Albrecht Waschke, Rolf Kalff, Christian Ewald
Background: Cerebellar hemorrhage is a potentially life-threatening condition and an understanding of the factors influencing outcome is essential for sound clinical decision-making. Methods: We retrospectively evaluated data from 50 consecutive patients who suffered a first spontaneous cerebellar hemorrhage (SCH) from 2005 to 2014, analysing their short-term outcomes and identifying possible clinical, radiological and therapeutic risk factors for poor prognosis and death within 30 days...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/29274026/clinical-and-demographic-profile-of-patients-receiving-fingolimod-in-clinical-practice-in-germany-and-the-benefit-risk-profile-of-fingolimod-after-1-year-of-treatment-initial-results-from-the-observational-noninterventional-study-pangaea
#5
Tjalf Ziemssen, Michael Lang, Björn Tackenberg, Stephan Schmidt, Holger Albrecht, Luisa Klotz, Judith Haas, Christoph Lassek, Jennie Medin, Christian Cornelissen
The population with multiple sclerosis receiving treatment in clinical practice differs from that in randomized controlled trials (RCTs). An assessment of the real-world benefit-risk profile of therapies is needed. This analysis used data from the large, noninterventional, observational German study Post-Authorization Non-interventional German sAfety study of GilEnyA (PANGAEA) to assess prospectively baseline characteristics and outcomes after 12 months (± 90 days) of fingolimod treatment. Patients were divided into 2 cohorts: fingolimod starter [first received fingolimod in PANGAEA (n = 3315)] and previous study [received fingolimod before enrollment in PANGAEA in RCTs (n = 875), some of whom also had baseline data at entry into RCTs (n = 505)]...
December 22, 2017: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/29258462/determinants-of-unmet-need-for-family-planning-in-rural-burkina-faso-a-multilevel-logistic-regression-analysis
#6
Joseph K Wulifan, Albrecht Jahn, Hervé Hien, Patrick Christian Ilboudo, Nicolas Meda, Paul Jacob Robyn, T Saidou Hamadou, Ousmane Haidara, Manuela De Allegri
BACKGROUND: Unmet need for family planning has implications for women and their families, such as unsafe abortion, physical abuse, and poor maternal health. Contraceptive knowledge has increased across low-income settings, yet unmet need remains high with little information on the factors explaining it. This study assessed factors associated with unmet need among pregnant women in rural Burkina Faso. METHOD: We collected data on pregnant women through a population-based survey conducted in 24 rural districts between October 2013 and March 2014...
December 19, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29247543/side-effects-during-subcutaneous-immunotherapy-scit-in-children-with-allergic-diseases
#7
Max Alfons Tophof, Anne Hermanns, Thomas Adelt, Peter Eberle, Christine Gronke, Frank Friedrichs, Roland Knecht, Ernst Mönter, Helmut Schöpfer, Nicolaus Schwerk, Jörg Steinbach, Hans-Ulrich Umpfenbach, Christian Weißhaar, Brigitte Wilmsmeyer, Albrecht Bufe
BACKGROUND: Allergen-specific immunotherapy (AIT) is the only causal form of therapy for IgE-mediated allergic diseases. Subcutaneous immunotherapy (SCIT) is considered safe and well tolerated in adults, yet there is less evidence of safety in the pediatric population. METHODS: A noninterventional prospective observing longitudinal study was carried out to determine the incidence of local and systemic side effects by SCIT, routinely performed in pediatric patients...
December 16, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29228149/outcome-after-transvascular-transcatheter-aortic-valve-implantation-in-2016
#8
Luise Gaede, Johannes Blumenstein, Christoph Liebetrau, Oliver Dörr, Won-Keun Kim, Holger Nef, Oliver Husser, Albrecht Elsässer, Christian W Hamm, Helge Möllmann
Aims: We analysed the number of procedures, complications, and in-hospital mortality rates of all patients undergoing transvascular transcatheter aortic valve implantation (TV-TAVI) in comparison to isolated surgical aortic valve replacement (iSAVR) from 2014 to 2016 in Germany. Methods and results: All aortic valve procedures performed in Germany are mandatorily registered in a quality control program. More than 15 000 TV-TAVI procedures were performed in 2016 in Germany...
December 8, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29181587/diagnostic-accuracy-of-low-and-high-tube-voltage-coronary-ct-angiography-using-an-x-ray-tube-potential-tailored-contrast-medium-injection-protocol
#9
Moritz H Albrecht, John W Nance, U Joseph Schoepf, Brian E Jacobs, Richard R Bayer, Sheldon E Litwin, Michael A Reynolds, Katharina Otani, Stefanie Mangold, Akos Varga-Szemes, Domenico De Santis, Marwen Eid, Georg Apfaltrer, Christian Tesche, Markus Goeller, Thomas J Vogl, Carlo N De Cecco
OBJECTIVES: To compare the diagnostic accuracy between low-kilovolt peak (kVp) (≤ 100) and high-kVp (> 100) third-generation dual-source coronary CT angiography (CCTA) using a kVp-tailored contrast media injection protocol. METHODS: One hundred twenty patients (mean age = 62.6 years, BMI = 29.0 kg/m2) who underwent catheter angiography and CCTA with automated kVp selection were separated into two cohorts (each n = 60, mean kVp = 84 and 117). Contrast media dose was tailored to the kVp level: 70 = 40 ml, 80 = 50 ml, 90 = 60 ml, 100 = 70 ml, 110 = 80 ml, and 120 = 90 ml...
November 27, 2017: European Radiology
https://www.readbyqxmd.com/read/29166912/neurofilament-distribution-in-the-superior-labrum-and-the-long-head-of-the-biceps-tendon
#10
Sandra Boesmueller, Antal Nógrádi, Patrick Heimel, Christian Albrecht, Sylvia Nürnberger, Heinz Redl, Christian Fialka, Rainer Mittermayr
BACKGROUND: The postoperative course after arthroscopic superior labrum anterior to posterior (SLAP) repair using suture anchors is accompanied by a prolonged period of pain, which might be caused by constriction of nerve fibres. The purpose was to histologically investigate the distribution of neurofilament in the superior labrum and the long head of the biceps tendon (LHBT), i.e. the location of type II SLAP lesions. METHODS: Ten LHBTs including the superior labrum were dissected from fresh human specimen and immunohistochemically stained against neurofilament (NF)...
November 22, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29150265/hypothesis-watershed-zones-in-the-human-eye-are-a-key-for-understanding-glaucomatous-retinal-damage
#11
Christian Albrecht May, Paul Rutkowski
The pathogenesis of glaucoma is complex which has led to numerous hypothesizes concerning the important factors creating this specific type of inner retinal degeneration namely apoptosis of retinal ganglion cells. We favor a primary vascular etiology and provide evidence that the pathogenesis of glaucoma should not be confined to changes exclusively at the optic nerve head but must include changes occurring in the peripheral retina with particular emphasis on the watershed zones of both the retina and choroid...
November 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/29102036/coronary-computed-tomographic-angiography-derived-fractional-flow-reserve-for-therapeutic-decision-making
#12
Christian Tesche, Rozemarijn Vliegenthart, Taylor M Duguay, Carlo N De Cecco, Moritz H Albrecht, Domenico De Santis, Marcel C Langenbach, Akos Varga-Szemes, Brian E Jacobs, David Jochheim, Moritz Baquet, Richard R Bayer, Sheldon E Litwin, Ellen Hoffmann, Daniel H Steinberg, U Joseph Schoepf
This study investigated the performance of coronary computed tomography angiography (cCTA) with cCTA-derived fractional flow reserve (CT-FFR) compared with invasive coronary angiography (ICA) with fractional flow reserve (FFR) for therapeutic decision making in patients with suspected coronary artery disease (CAD). Seventy-four patients (62 ± 11 years, 62% men) with at least 1 coronary stenosis of ≥50% on clinically indicated dual-source cCTA, who had subsequently undergone ICA with FFR measurement, were retrospectively evaluated...
September 19, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29098687/the-human-platysma-contains-numerous-muscle-spindles
#13
Astrid May, Silvia Bramke, Richard H W Funk, Christian Albrecht May
The mimic muscles are usually described as containing no muscle spindles. In the present publication the human platysma was reinvestigated concerning its content of corpuscular sensors. Serial sections through the platysma of seven donors revealed numerous muscle spindles but no Pacini corpuscules. The muscle spindles were located in the cranial two-thirds of the platysma, and were evenly distributed with a tendency to have more spindles in the lateral part of the muscle. Immunohistochemical staining with S46 antibodies revealed a predominance of nuclear bag fibers...
November 3, 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/29092481/a-general-approach-to-obtain-soft-x-ray-transparency-for-thin-films-grown-on-bulk-substrates
#14
Manuel Fohler, Stefanie Frömmel, Michael Schneider, Bastian Pfau, Christian M Günther, Martin Hennecke, Erik Guehrs, Laura Shemilt, Durgamadhab Mishra, Dirk Berger, Sören Selve, Dmitriy Mitin, Manfred Albrecht, Stefan Eisebitt
We present a general approach to thin bulk samples to transparency for experiments in the soft x-ray and extreme ultraviolet spectral range. The method relies on mechanical grinding followed by focused-ion-beam milling. It results in a uniformly thin area of high surface quality, suitable for nanoscale imaging in transmission. In a proof-of-principle experiment, nanoscale magnetic bits on a commercial hard drive glass disk are imaged with a spatial resolution below 30 nm by soft x-ray spectro-holography. Furthermore, we demonstrate imaging of a lithographically patterned test object via absorption contrast...
October 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/29062282/model-based-targeting-of-il-6-induced-inflammatory-responses-in-cultured-primary-hepatocytes-to-improve-application-of-the-jak-inhibitor-ruxolitinib
#15
Svantje Sobotta, Andreas Raue, Xiaoyun Huang, Joep Vanlier, Anja Jünger, Sebastian Bohl, Ute Albrecht, Maximilian J Hahnel, Stephanie Wolf, Nikola S Mueller, Lorenza A D'Alessandro, Stephanie Mueller-Bohl, Martin E Boehm, Philippe Lucarelli, Sandra Bonefas, Georg Damm, Daniel Seehofer, Wolf D Lehmann, Stefan Rose-John, Frank van der Hoeven, Norbert Gretz, Fabian J Theis, Christian Ehlting, Johannes G Bode, Jens Timmer, Marcel Schilling, Ursula Klingmüller
IL-6 is a central mediator of the immediate induction of hepatic acute phase proteins (APP) in the liver during infection and after injury, but increased IL-6 activity has been associated with multiple pathological conditions. In hepatocytes, IL-6 activates JAK1-STAT3 signaling that induces the negative feedback regulator SOCS3 and expression of APPs. While different inhibitors of IL-6-induced JAK1-STAT3-signaling have been developed, understanding their precise impact on signaling dynamics requires a systems biology approach...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29029087/the-effect-of-sacubitril-valsartan-compared-to-olmesartan-on-cardiovascular-remodelling-in-subjects-with-essential-hypertension-the-results-of-a-randomized-double-blind-active-controlled-study
#16
Roland E Schmieder, Frank Wagner, Michael Mayr, Christian Delles, Christian Ott, Christian Keicher, Maja Hrabak-Paar, Tobias Heye, Solveig Aichner, Yasser Khder, Denise Yates, Diego Albrecht, Thomas Langenickel, Patrick Freyhardt, Rolf Janka, Jens Bremerich
Aims: Progressive aortic stiffening eventually leads to left ventricular (LV) hypertrophy and heart failure if left untreated. Anti-hypertensive agents have been shown to reverse this to some extent. The effects of sacubitril/valsartan (LCZ696), a dual-action angiotensin receptor blocker (ARB), and neprilysin inhibitor, on arterial stiffness and LV remodelling have not been investigated. Methods and results: This was a randomized, multi-centre, double-blind, double-dummy, active-controlled, parallel group, study to compare the effects on cardiovascular remodelling of sacubitril/valsartan with those of olmesartan in patients with hypertension and elevated pulse pressure...
September 27, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28987652/dual-energy-computed-tomography-in-patients-with-cutaneous-malignant-melanoma-comparison-of-noise-optimized-and-traditional-virtual-monoenergetic-imaging
#17
Simon S Martin, Julian L Wichmann, Hendrik Weyer, Moritz H Albrecht, Tommaso D'Angelo, Doris Leithner, Lukas Lenga, Christian Booz, Jan-Erik Scholtz, Boris Bodelle, Thomas J Vogl, Renate Hammerstingl
OBJECTIVE: The aim of this study was to investigate the impact of noise-optimized virtual monoenergetic imaging (VMI+) reconstructions on quantitative and qualitative image parameters in patients with cutaneous malignant melanoma at thoracoabdominal dual-energy computed tomography (DECT). MATERIALS AND METHODS: Seventy-six patients (48 men; 66.6±13.8years) with metastatic cutaneous malignant melanoma underwent DECT of the thorax and abdomen. Images were post-processed with standard linear blending (M_0...
October 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28963581/pacemaker-implantation-after-tavi-predictors-of-av-block-persistence
#18
Luise Gaede, Won-Keun Kim, Christoph Liebetrau, Oliver Dörr, Johannes Sperzel, Johannes Blumenstein, Alexander Berkowitsch, Thomas Walther, Christian Hamm, Albrecht Elsässer, Holger Nef, Helge Möllmann
AIMS: Approximately every fifth patient undergoing transcatheter aortic valve implantation (TAVI) requires a permanent pacemaker (PPM) after the procedure. The aim of this study was to analyse predictors of atrioventricular block III° (AVBIII) persistence with concurrent PPM dependency after TAVI. METHODS AND RESULTS: Between 2010 and 2015 a total of 1198 patients underwent TAVI at the Kerckhoff Heart and Thorax Center, Germany. After exclusion of patients with prior PPM (n = 173) 14...
September 29, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28926310/coronary-ct-angiography-derived-fractional-flow-reserve
#19
Christian Tesche, Carlo N De Cecco, Moritz H Albrecht, Taylor M Duguay, Richard R Bayer, Sheldon E Litwin, Daniel H Steinberg, U Joseph Schoepf
Invasive coronary angiography (ICA) with measurement of fractional flow reserve (FFR) by means of a pressure wire technique is the established reference standard for the functional assessment of coronary artery disease (CAD) ( 1 , 2 ). Coronary computed tomographic (CT) angiography has emerged as a noninvasive method for direct assessment of CAD and plaque characterization with high diagnostic accuracy compared with ICA ( 3 , 4 ). However, the solely anatomic assessment provided with both coronary CT angiography and ICA has poor discriminatory power for ischemia-inducing lesions...
October 2017: Radiology
https://www.readbyqxmd.com/read/28920997/rapid-and-highly-sensitive-detection-of-extracellular-and-intracellular-h2s-by-an-azide-functionalized-al-iii-based-metal-organic-framework
#20
Soutick Nandi, Helge Reinsch, Sooram Banesh, Norbert Stock, Vishal Trivedi, Shyam Biswas
A new, azide-functionalized Al(iii)-based metal-organic framework (MOF) denoted as CAU-10-N3 (1, CAU = Christian-Albrechts-University) and consisting of the 5-azido-isophthalic acid (H2IPA-N3) ligand was employed as a reaction-based fluorescent turn-on probe for the detection of H2S. The activated compound (1') showed fast, selective and highly sensitive sensing properties for extracellular H2S in HEPES buffer (10 mM, pH = 7.4). The material retained its high selectivity even in the presence of possibly competing biological species...
September 18, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
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