keyword
https://read.qxmd.com/read/38473273/breast-tumor-metastasis-and-its-microenvironment-it-takes-both-seed-and-soil-to-grow-a-tumor-and-target-it-for-treatment
#1
REVIEW
Shirin Bonni, David N Brindley, M Dean Chamberlain, Nima Daneshvar-Baghbadorani, Andrew Freywald, Denise G Hemmings, Sabine Hombach-Klonisch, Thomas Klonisch, Afshin Raouf, Carrie Simone Shemanko, Diana Topolnitska, Kaitlyn Visser, Franco J Vizeacoumar, Edwin Wang, Spencer B Gibson
Metastasis remains a major challenge in treating breast cancer. Breast tumors metastasize to organ-specific locations such as the brain, lungs, and bone, but why some organs are favored over others remains unclear. Breast tumors also show heterogeneity, plasticity, and distinct microenvironments. This contributes to treatment failure and relapse. The interaction of breast cancer cells with their metastatic microenvironment has led to the concept that primary breast cancer cells act as seeds, whereas the metastatic tissue microenvironment (TME) is the soil...
February 23, 2024: Cancers
https://read.qxmd.com/read/38104083/trauma-patient-transport-to-hospital-using-helicopter-emergency-medical-services-or-road-ambulance-in-sweden-a-comparison-of-survival-and-prehospital-time-intervals
#2
JOURNAL ARTICLE
Oscar Lapidus, Rebecka Rubenson Wahlin, Denise Bäckström
BACKGROUND: The benefits of helicopter emergency medical services (HEMS) transport of adults following major trauma have been examined with mixed results, with some studies reporting a survival benefit compared to regular emergency medical services (EMS). The benefit of HEMS in the context of the Swedish trauma system remains unclear. AIM: To investigate differences in survival and prehospital time intervals for trauma patients in Sweden transported by HEMS compared to road ambulance EMS...
December 16, 2023: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://read.qxmd.com/read/36103993/%C3%AE-blockers-activate-autophagy-on-infantile-hemangioma-derived-endothelial-cells-in-vitro
#3
JOURNAL ARTICLE
Bruno Lorusso, Giuseppe Cerasoli, Angela Falco, Caterina Frati, Gallia Graiani, Denise Madeddu, Antonella Nogara, Emilia Corradini, Giovanni Roti, Elisa Cerretani, Andrea Gherli, Mariafrancesca Caputi, Letizia Gnetti, Francesco Paolo Pilato, Federico Quaini, Costanza Lagrasta
The mechanisms underlying the success of propranolol in the treatment of infantile hemangioma (IH) remain elusive and do not fully explain the rapid regression of hemangiomatous lesions following drug administration. As autophagy is critically implicated in vascular homeostasis, we determined whether β-blockers trigger the autophagic flux on infantile hemangioma-derived endothelial cells (Hem-ECs) in vitro. MATERIAL AND METHODS: Fresh tissue specimens, surgically removed for therapeutic purpose to seven children affected by proliferative IH, were subjected to enzymatic digestion...
September 11, 2022: Vascular Pharmacology
https://read.qxmd.com/read/35409108/tumor-necrosis-factor-%C3%AE-induces-a-preeclamptic-like-phenotype-in-placental-villi-via-sphingosine-kinase-1-activation
#4
JOURNAL ARTICLE
Yuliya Fakhr, Saloni Koshti, Yasaman Bahojb Habibyan, Kirsten Webster, Denise G Hemmings
Preeclampsia (PE) involves inadequate placental function. This can occur due to elevated pro-inflammatory tumor necrosis factor-α (TNF-α). In other tissues, TNF-α signals via sphingosine kinase 1 (SphK1). SphK1 hinders syncytial formation. Whether this occurs downstream of TNF-α signaling is unclear. We hypothesized that placental SphK1 levels are higher in PE and elevated TNF-α decreases syncytial function, increases syncytial shedding, and increases cytokine/factor release via SphK1 activity. Term placental biopsies were analyzed for SphK1 using immunofluorescence and qRT-PCR...
March 29, 2022: International Journal of Molecular Sciences
https://read.qxmd.com/read/34575976/pdgfr%C3%AE-enhanced-infection-of-breast-cancer-cells-with-human-cytomegalovirus-but-infection-of-fibroblasts-increased-prometastatic-inflammation-involving-lysophosphatidate-signaling
#5
JOURNAL ARTICLE
Zelei Yang, Xiaoyun Tang, Todd P W McMullen, David N Brindley, Denise G Hemmings
Human cytomegalovirus (HCMV) infects 40-70% of adults in developed countries. HCMV proteins and DNA are detected in tumors and metastases, suggesting an association with increased invasion. We investigated HCMV infection in human breast cancer cell lines compared to fibroblasts, a component of tumors, and the role of platelet-derived growth factor receptor-α (PDGFRα). HCMV productively infected HEL299 fibroblasts and, to a lesser extent, Hs578T breast cancer cells. Infection of another triple-negative cell line, MDA-MB-231, and also MCF-7 cells, was extremely low...
September 10, 2021: International Journal of Molecular Sciences
https://read.qxmd.com/read/34415509/lysophosphatidate-promotes-sphingosine-1-phosphate-metabolism-and-signaling-implications-for-breast-cancer-and-doxorubicin-resistance
#6
JOURNAL ARTICLE
Ganesh Venkatraman, Xiaoyun Tang, Guangwei Du, Amadeo M Parisentti, Denise G Hemmings, David N Brindley
Lysophosphatidate (LPA) and sphingosine 1-phosphate (S1P) promote vasculogenesis, angiogenesis, and wound healing by activating a plethora of overlapping signaling pathways that stimulate mitogenesis, cell survival, and migration. As such, maladaptive signaling by LPA and S1P have major effects in increasing tumor progression and producing poor patient outcomes after chemotherapy and radiotherapy. Many signaling actions of S1P and LPA are not redundant; each are vital in normal physiology and their metabolisms differ...
September 2021: Cell Biochemistry and Biophysics
https://read.qxmd.com/read/34004349/sphingosine-1-phosphate-induced-nitric-oxide-production-simultaneously-controls-endothelial-barrier-function-and-vascular-tone-in-resistance-arteries
#7
JOURNAL ARTICLE
Daniel Kerage, Randi B Gombos, Shaomeng Wang, Meagan Brown, Denise G Hemmings
The regulations of endothelial permeability and vascular tone by the sphingosine 1-phosphate (S1P) have been well-studied independently. Little is known about whether effects of S1P on endothelial permeability can directly influence vascular tone in resistance arteries, which impact blood flow. The endothelium forms a partial barrier that regulates access of circulating agonists to underlying vascular smooth muscle cells (VSMCs). We hypothesized that physiological concentrations of circulating S1P simultaneously control endothelial barrier function and vascular tone through endothelial production of nitric oxide (NO)...
May 15, 2021: Vascular Pharmacology
https://read.qxmd.com/read/33991614/physiological-and-pathological-functions-of-sphingolipids-in-pregnancy
#8
JOURNAL ARTICLE
Yuliya Fakhr, David N Brindley, Denise G Hemmings
Signaling by the bioactive sphingolipid, sphingosine 1-phosphate (S1P), and its precursors during pregnancy are emerging areas in pregnancy research. S1P and ceramide levels increase towards end of gestation, suggesting a physiological role in parturition. However, high levels of circulating S1P and ceramide are correlated with pregnancy disorders such as preeclampsia, gestational diabetes mellitus and intrauterine growth restriction. Expression of placental and decidual enzymes that metabolize S1P and S1P receptors are also dysregulated during pregnancy complications...
May 12, 2021: Cellular Signalling
https://read.qxmd.com/read/33672607/unmet-medical-needs-and-future-perspectives-for-leiomyosarcoma-patients-a-position-paper-from-the-national-leiomyosarcoma-foundation-nlmsf-and-sarcoma-patients-euronet-spaen
#9
REVIEW
Bernd Kasper, Annie Achee, Kathrin Schuster, Roger Wilson, Gerard van Oortmerssen, Rebecca A Gladdy, Matthew L Hemming, Paul Huang, Matthew Ingham, Robin L Jones, Seth M Pollack, Denise Reinke, Roberta Sanfilippo, Scott M Schuetze, Neeta Somaiah, Brian A Van Tine, Breelyn Wilky, Scott Okuno, Jonathan Trent
As leiomyosarcoma patients are challenged by the development of metastatic disease, effective systemic therapies are the cornerstone of outcome. However, the overall activity of the currently available conventional systemic treatments and the prognosis of patients with advanced or metastatic disease are still poor, making the treatment of this patient group challenging. Therefore, in a joint effort together with patient networks and organizations, namely Sarcoma Patients EuroNet (SPAEN), the international network of sarcoma patients organizations, and the National LeioMyoSarcoma Foundation (NLMSF) in the United States, we aim to summarize state-of-the-art treatments for leiomyosarcoma patients in order to identify knowledge gaps and current unmet needs, thereby guiding the community to design innovative clinical trials and basic research and close these research gaps...
February 20, 2021: Cancers
https://read.qxmd.com/read/33170741/guidelines-for-modeling-and-reporting-health-effects-of-climate-change-mitigation-actions
#10
JOURNAL ARTICLE
Jeremy J Hess, Nikhil Ranadive, Chris Boyer, Lukasz Aleksandrowicz, Susan C Anenberg, Kristin Aunan, Kristine Belesova, Michelle L Bell, Sam Bickersteth, Kathryn Bowen, Marci Burden, Diarmid Campbell-Lendrum, Elizabeth Carlton, Guéladio Cissé, Francois Cohen, Hancheng Dai, Alan David Dangour, Purnamita Dasgupta, Howard Frumkin, Peng Gong, Robert J Gould, Andy Haines, Simon Hales, Ian Hamilton, Tomoko Hasegawa, Masahiro Hashizume, Yasushi Honda, Daniel E Horton, Alexandra Karambelas, Ho Kim, Satbyul Estella Kim, Patrick L Kinney, Inza Kone, Kim Knowlton, Jos Lelieveld, Vijay S Limaye, Qiyong Liu, Lina Madaniyazi, Micaela Elvira Martinez, Denise L Mauzerall, James Milner, Tara Neville, Mark Nieuwenhuijsen, Shonali Pachauri, Frederica Perera, Helen Pineo, Justin V Remais, Rebecca K Saari, Jon Sampedro, Pauline Scheelbeek, Joel Schwartz, Drew Shindell, Priya Shyamsundar, Timothy J Taylor, Cathryn Tonne, Detlef Van Vuuren, Can Wang, Nicholas Watts, J Jason West, Paul Wilkinson, Stephen A Wood, James Woodcock, Alistair Woodward, Yang Xie, Ying Zhang, Kristie L Ebi
BACKGROUND: Modeling suggests that climate change mitigation actions can have substantial human health benefits that accrue quickly and locally. Documenting the benefits can help drive more ambitious and health-protective climate change mitigation actions; however, documenting the adverse health effects can help to avoid them. Estimating the health effects of mitigation (HEM) actions can help policy makers prioritize investments based not only on mitigation potential but also on expected health benefits...
November 2020: Environmental Health Perspectives
https://read.qxmd.com/read/32451553/signalling-by-lysophosphatidate-and-its-health-implications
#11
REVIEW
Denise G Hemmings, David N Brindley
Extracellular lysophosphatidate (LPA) signalling is regulated by the balance of LPA formation by autotaxin (ATX) versus LPA degradation by lipid phosphate phosphatases (LPP) and by the relative expressions of six G-protein-coupled LPA receptors. These receptors increase cell proliferation, migration, survival and angiogenesis. Acute inflammation produced by tissue damage stimulates ATX production and LPA signalling as a component of wound healing. If inflammation does not resolve, LPA signalling becomes maladaptive in conditions including arthritis, neurologic pain, obesity and cancers...
September 23, 2020: Essays in Biochemistry
https://read.qxmd.com/read/31736042/health-emergency-management-in-aotearoa-new-zealand-making-sense-of-professional-development
#12
JOURNAL ARTICLE
Denise Blake, Patricia Niland, David M Johnston
OBJECTIVE: To explore how health emergency management (HEM) personnel make sense of professional development, such as education and training, in their everyday roles and responsibilities within an increasingly complex emergency management and disaster field. DESIGN: This in-depth qualitative study comprised of semistructured interviews with 10 Aotearoa New Zealand HEM personnel from a range of healthcare professions, including emergency managers, nurses, clinical support, and paramedics...
September 2019: Journal of Emergency Management: JEM
https://read.qxmd.com/read/30934926/latent-cytomegalovirus-infection-in-female-mice-increases-breast-cancer-metastasis
#13
JOURNAL ARTICLE
Zelei Yang, Xiaoyun Tang, Guanmin Meng, Matthew G K Benesch, Martina Mackova, Ana Paula Belon, Jesus Serrano-Lomelin, Ing Swie Goping, David N Brindley, Denise G Hemmings
Cytomegalovirus (CMV) infects 40⁻70% of women, but infection has been reported in >95% of breast cancer patients. We investigated the consequences of these observations by infecting mice with mCMV or a negative control medium for 4 days, 11 days or 10 weeks to establish active, intermediate or latent infections, respectively. Syngeneic 4T1 or E0771 breast cancer cells were then injected into a mammary fat pad of BALB/c or C57BL/6 mice, respectively. Infection did not affect tumor growth in these conditions, but latently infected BALB/c mice developed more lung metastases...
March 29, 2019: Cancers
https://read.qxmd.com/read/30383759/characterization-of-maternal-plasma-biomarkers-associated-with-delivery-of-small-and-large-for-gestational-age-infants-in-the-mirec-study-cohort
#14
JOURNAL ARTICLE
Premkumari Kumarathasan, Gabriela Williams, Agnieszka Bielecki, Erica Blais, Denise G Hemmings, Graeme Smith, Peter von Dadelszen, Mandy Fisher, Tye E Arbuckle, William D Fraser, Renaud Vincent
OBJECTIVE: Neonatal morbidity and mortality can be influenced by maternal health status. Information on maternal and fetal biomarkers of adverse health outcomes is limited. This work aims at identifying maternal biomarkers associated with low and high birth weight for gestational age groups. DESIGN AND SETTINGS: Population-based prospective cohort study of the potential adverse health effects of exposure to environmental contaminants on pregnancy and infant health...
2018: PloS One
https://read.qxmd.com/read/29336764/mode-of-transport-and-clinical-outcome-in-rural-trauma-a-helicopter-versus-ambulance-comparison
#15
COMPARATIVE STUDY
Mahdi Malekpour, Jabran M Younus, Kathryn Jaap, Nina Neuhaus, Kenneth Widom, Megan Rapp, James Dove, Marie Hunsinger, Joseph Blansfield, Mohsen Shabahang, Denise Torres, Jeffrey Wild
Helicopter Emergency Medical Services (HEMS) is presumably an effective way of patient transport in rural trauma, yet the literature addressing its effectiveness is scarce. In this study, we compared the clinical outcome of rural trauma patients between Ground Emergency Medical Services (GEMS) and HEMS transportation from the beginning of 2006 to the end of 2012. Focus was placed on identifying factors associated with survival to discharge in these patients. Over the seven-year study period, 4492 patients met the inclusion criteria with 2414 patients (54%) being transferred by GEMS and 2078 patients (46%) being transferred by HEMS...
December 1, 2017: American Surgeon
https://read.qxmd.com/read/28943478/sexual-dimorphism-of-metabolic-and-vascular-dysfunction-in-aged-mice-and-those-lacking-the-sphingosine-1-phosphate-receptor-3
#16
JOURNAL ARTICLE
Amanda T Cao, Martina Mackova, Daniel Kerage, David N Brindley, Denise G Hemmings
Elderly people often suffer adverse health because of inflammation associated with poor metabolism and cardiovascular dysfunction, but these conditions present differently in men and women. We performed experiments in aged male and female mice to understand this sexual dimorphism. We focused on sphingosine 1-phosphate (S1P) signaling, which has both protective and detrimental effects on vascular and metabolic function. We examined vascular function of mesenteric (resistance) arteries from aged male and female wild-type (WT) mice compared to littermate S1P receptor 3 (S1PR3) knockouts (KO)...
December 1, 2017: Experimental Gerontology
https://read.qxmd.com/read/28855042/insulinotropic-nucleobindin-2-nesfatin-1-is-dynamically-expressed-in-the-haemochorial-mouse-and-human-placenta
#17
JOURNAL ARTICLE
Crystalyn B Legg-St Pierre, Martina Mackova, Ewa I Miskiewicz, Denise G Hemmings, Suraj Unniappan, Daniel J MacPhee
The placenta is the physiological bridge between mother and fetus and has life-sustaining functions during pregnancy, including metabolic regulation, fetal protection and hormone secretion. Nucleobindin-2 (NUCB2) is a calcium- and DNA-binding protein and precursor of nesfatin-1, a signalling peptide with multiple functions, including regulation of energy homeostasis and glucose transport. These are also key functions of the placenta, yet NUCB2/nesfatin-1 expression has never been comprehensively studied in this organ...
March 2018: Reproduction, Fertility, and Development
https://read.qxmd.com/read/28539367/implications-for-breast-cancer-treatment-from-increased-autotaxin-production-in-adipose-tissue-after-radiotherapy
#18
JOURNAL ARTICLE
Guanmin Meng, Xiaoyun Tang, Zelei Yang, Matthew G K Benesch, Alison Marshall, David Murray, Denise G Hemmings, Frank Wuest, Todd P W McMullen, David N Brindley
We have previously established that adipose tissue adjacent to breast tumors becomes inflamed by tumor-derived cytokines. This stimulates autotaxin (ATX) secretion from adipocytes, whereas breast cancer cells produce insignificant ATX. Lysophosphatidate produced by ATX promotes inflammatory cytokine secretion in a vicious inflammatory cycle, which increases tumor growth and metastasis and decreases response to chemotherapy. We hypothesized that damage to adipose tissue during radiotherapy for breast cancer should promote lysophosphatidic acid (LPA) signaling and further inflammatory signaling, which could potentially protect cancer cells from subsequent fractions of radiation therapy...
September 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/26143929/high-fructose-consumption-in-pregnancy-alters-the-perinatal-environment-without-increasing-metabolic-disease-in-the-offspring
#19
JOURNAL ARTICLE
Christopher Lineker, Paul M Kerr, Patricia Nguyen, Ian Bloor, Stuart Astbury, Nikhil Patel, Helen Budge, Denise G Hemmings, Frances Plane, Michael E Symonds, Rhonda C Bell
Maternal carbohydrate intake is one important determinant of fetal body composition, but whether increased exposure to individual sugars has long-term adverse effects on the offspring is not well established. Therefore, we examined the effect of fructose feeding on the mother, placenta, fetus and her offspring up to 6 months of life when they had been weaned onto a standard rodent diet and not exposed to additional fructose. Dams fed fructose were fatter, had raised plasma insulin and triglycerides from mid-gestation and higher glucose near term...
October 2016: Reproduction, Fertility, and Development
https://read.qxmd.com/read/26071407/tumor-induced-inflammation-in-mammary-adipose-tissue-stimulates-a-vicious-cycle-of-autotaxin-expression-and-breast-cancer-progression
#20
JOURNAL ARTICLE
Matthew G K Benesch, Xiaoyun Tang, Jay Dewald, Wei-Feng Dong, John R Mackey, Denise G Hemmings, Todd P W McMullen, David N Brindley
Compared to normal tissues, many cancer cells overexpress autotaxin (ATX). This secreted enzyme produces extracellular lysophosphatidate, which signals through 6 GPCRs to drive cancer progression. Our previous work showed that ATX inhibition decreases 4T1 breast tumor growth in BALB/c mice by 60% for about 11 d. However, 4T1 cells do not produce significant ATX. Instead, the ATX is produced by adjacent mammary adipose tissue. We investigated the molecular basis of this interaction in human and mouse breast tumors...
September 2015: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
keyword
keyword
101387
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.