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https://www.readbyqxmd.com/read/28105685/evolution-of-gas-permeable-membranes-for-extracorporeal-membrane-oxygenation
#1
REVIEW
Torin Yeager, Shuvo Roy
Gas permeable membranes are a vital component of extracorporeal membrane oxygenation systems. Over more than half a century, membrane fabrication and packaging technology have progressed to enable safer and longer duration use of respiratory life support. Current research efforts seek to improve membrane efficiency and hemocompatibility, with the aim of producing smaller and more robust systems for ambulatory use. This review explores past and present innovations in oxygenator technology, suggesting possible applications of state-of-the-art membrane fabrication methods to address shortcomings of earlier concepts...
January 19, 2017: Artificial Organs
https://www.readbyqxmd.com/read/28104526/total-navigation-in-spine-surgery-a-concise-guide-to-eliminate-fluoroscopy-using-a-portable-intraoperative-ct-3d-navigation-system
#2
Rodrigo Navarro-Ramirez, Gernot Lang, Xiaofeng Lian, Connor Berlin, Insa Janssen, Ajit Jada, Marjan Alimi, Roger Härtl
BACKGROUND: Portable intraoperative computed tomography (iCT) with integrated 3D navigation offers new opportunities for more precise navigation in spinal surgery, eliminates radiation exposure for the surgical team and accelerates surgical workflows. We present the concept of "total navigation" using iCT NAV in spinal surgery. Therefore, we propose a step-by-step guideline demonstrating how total navigation can eliminate fluoroscopy with time efficient workflows integrating iCT NAV into daily practice...
January 16, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28098921/-does-less-seclusion-create-a-safer-environment-an-attempt-to-map-the-concept-of-feeling-safe
#3
C J Severs, A J K Hondius, A H Schene
The degree of restraint imposed by a psychiatrist seems to be influenced by the safety of the team. So far, there have been few attempts to map the concept of 'feeling safe'.<br/> AIM: To analyse, define and quantify the concept of 'feeling safe'.<br/> METHOD: Concept mapping involves combining, in a structured way, qualitative (item collection) and quantitative methods (multi-dimensional scaling and hierarchical clusteranalysis) with the knowledge of professionals from psychiatric practice (N=24), first on an individual basis and then as a group (N=8)...
2017: Tijdschrift Voor Psychiatrie
https://www.readbyqxmd.com/read/28088527/navigation-in-the-electronic-health-record-a-review-of-the-safety-and-usability-literature
#4
REVIEW
Lisette C Roman, Jessica S Ancker, Stephen B Johnson, Yalini Senathirajah
OBJECTIVE: Inefficient navigation in electronic health records has been shown to increase users' cognitive load, which may increase potential for errors, reduce efficiency, and increase fatigue. However, navigation has received insufficient recognition and attention in the electronic health record (EHR) literature as an independent construct and contributor to overall usability. Our aims in this literature review were to (1) assess the prevalence of navigation-related topics within the EHR usability and safety research literature, (2) categorize types of navigation actions within the EHR, (3) capture relationships between these navigation actions and usability principles, and (4) collect terms and concepts related to EHR navigation...
January 11, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28075482/human-induced-pluripotent-stem-hips-cells-from-urine-samples-a-non-integrative-and-feeder-free-reprogramming-strategy
#5
Clara Steichen, Karim Si-Tayeb, Fanny Wulkan, Thayane Crestani, Graça Rosas, Rafael Dariolli, Alexandre C Pereira, Jose E Krieger
Human induced pluripotent stem (hiPS) cell technology has already revolutionized some aspects of fundamental and applied research such as study of disease mechanisms and pharmacology screening. The first clinical trial using hiPS cell-derived cells began in Japan, only 10 years after the publication of the proof-of concept article. In this exciting context, strategies to generate hiPS cells have evolved quickly, tending towards non-invasive protocols to sample somatic cells combined with "safer" reprogramming strategies...
January 11, 2017: Current Protocols in Human Genetics
https://www.readbyqxmd.com/read/28060982/-ethical-dilemmas-about-disclosure-of-errors-in-medicine
#6
Sebastián Lavanderos, Juan Pedraza, Moisés Russo N, Sofía P Salas
Since the publication of the Institute of Medicine’s report “To Err is Human: Building a Safer Health System” awareness of the importance of medical errors has increased. These are a major cause of morbidity and mortality and recent studies suggest that they can be the third leading cause of death in the United States. Difficulties have been identified by health personnel to prevent, detect and disclose to patients the occurrence of a medical error, an also to report them to the appropriate authorities. Although human error cannot be eliminated, it is possible to design safety systems to mitigate their frequency and consequences...
September 2016: Revista Médica de Chile
https://www.readbyqxmd.com/read/28060329/drug-repurposing-hypothesis-generation-using-the-re-fine-drugs-system
#7
Kelly Regan, Soheil Moosavinasab, Philip Payne, Simon Lin
The promise of drug repurposing is that existing drugs may be used for new disease indications in order to curb the high costs and time for approval. The goal of computational methods for drug repurposing is to enable solutions for safer, cheaper and faster drug discovery. Towards this end, we developed a novel method that integrates genetic and clinical phenotype data from large-scale GWAS and PheWAS studies with detailed drug information on the concept of transitive Drug-Gene-Disease triads. We created "RE:fine Drugs," a freely available, interactive dashboard that automates gene, disease and drug-based searches to identify drug repurposing candidates...
December 11, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28010827/-is-it-all-right-for-me-to-have-a-baby-or-not-men-living-with-hiv-discuss-fertility-desires-and-interactions-with-providers
#8
Shannon Weber, Jennifer M Zakaras, Starr Hilliard, Deborah Cohan, Shari L Dworkin
To our knowledge, no study in the United States has qualitatively examined fertility desires, experiences communicating with health care providers about sexual and reproductive health, and attitudes toward reproductive counseling and services in men living with HIV (MLWH) who have sex with women. We conducted focus groups and interviews with MLWH (N = 17) who have sex with women seeking HIV care in San Francisco. The men conveyed limited awareness of safer conception strategies. While many men expressed the desire to have a child, most reported that their providers had not discussed reproduction with them...
January 2017: Journal of the Association of Nurses in AIDS Care: JANAC
https://www.readbyqxmd.com/read/27980116/innate-immunity-stimulation-via-toll-like-receptor-9-ameliorates-vascular-amyloid-pathology-in-tg-swdi-mice-with-associated-cognitive-benefits
#9
Henrieta Scholtzova, Eileen Do, Shleshma Dhakal, Yanjie Sun, Shan Liu, Pankaj D Mehta, Thomas Wisniewski
: Alzheimer's disease (AD) is characterized by the presence of parenchymal amyloid-beta (Aβ) plaques, cerebral amyloid angiopathy (CAA) and neurofibrillary tangles. Currently there are no effective treatments for AD. Immunotherapeutic approaches under development are hampered by complications related to ineffectual clearance of CAA. Genome-wide association studies have demonstrated the importance of microglia in AD pathogenesis. Microglia are the primary innate immune cells of the brain, and depending on their activation state and environment can have beneficial or detrimental effects...
December 15, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27938871/client-and-provider-knowledge-and-views-on-safer-conception-for-people-living-with-hiv-plhiv
#10
Deborah L Mindry, Cecilia Milford, Letitia Greener, Ross M Greener, Pranitha Maharaj, Thabo Letsoalo, Chantal Munthree, Tamaryn L Crankshaw, Jennifer A Smit
OBJECTIVE(S): The childbearing needs of people living with HIV (PLHIV) and the experiences of healthcare providers serving them are explored. We examine provider and client knowledge and views on safer conception methods. METHODS: The study uses exploratory qualitative research to understand provider and client perspectives on childbearing and safer conception. Interviews were conducted at 3 sites (1 rural, 2 urban) in eThekwini District, KwaZulu-Natal, South Africa between May 2011 and August 2012, including in-depth interviews with 43 PLHIV, 2 focus group discussions and 12 in-depth interviews with providers...
December 2016: Sexual & Reproductive Healthcare: Official Journal of the Swedish Association of Midwives
https://www.readbyqxmd.com/read/27925487/a-novel-safer-conception-counseling-toolkit-for-the-prevention-of-hiv-a-mixed-methods-evaluation-in-kisumu-kenya
#11
Joelle Brown, Betty Njoroge, Eliud Akama, Brooke Breitnauer, Anna Leddy, Lynae Darbes, Richard Omondi, Okeoma Mmeje
Safer conception strategies can prevent HIV transmission between HIV-discordant partners while allowing them to conceive. However, HIV care providers in sub-Saharan Africa report they are not trained in safer conception, and patients are not routinely offered safer conception services. This mixed-methods pilot study evaluated the impact, acceptability, and feasibility of a novel Safer Conception Counseling Toolkit among providers and patients in Kenya. We enrolled 20 HIV-positive women, 10 HIV-discordant couples, and 10 providers from HIV care and treatment clinics...
December 2016: AIDS Education and Prevention: Official Publication of the International Society for AIDS Education
https://www.readbyqxmd.com/read/27915360/patient-safety-organizations-and-emergency-medical-services
#12
William J Leggio, Lee Varner, Kathryn Wire
Providing safe and error-free patient care should resonate well with all healthcare providers including emergency medical technicians. The environments and circumstances in which emergency medical services (EMS) provide patient care inevitably create risks to both the provider and patient. This article explores the concepts of patient safety, errors, near misses, adverse events, and Just Culture. Literature raises concerns about the lack of data collection on both patient and provider safety and research on these safety topics in EMS...
2016: Journal of Allied Health
https://www.readbyqxmd.com/read/27906009/current-trends-and-intricacies-in-the-management-of-hiv-associated-pulmonary-tuberculosis
#13
REVIEW
Narendran Gopalan, Padmapriyadarsini Chandrasekaran, Soumya Swaminathan, Srikanth Tripathy
Human immunodeficiency virus (HIV) epidemic has undoubtedly increased the incidence of tuberculosis (TB) globally, posing a formidable global health challenge affecting 1.2 million cases. Pulmonary TB assumes utmost significance in the programmatic perspective as it is readily transmissible as well as easily diagnosable. HIV complicates every aspect of pulmonary tuberculosis from diagnosis to treatment, demanding a different approach to effectively tackle both the diseases. In order to control these converging epidemics, it is important to diagnose early, initiate appropriate therapy for both infections, prevent transmission and administer preventive therapy...
September 26, 2016: AIDS Research and Therapy
https://www.readbyqxmd.com/read/27891492/effect-of-magnetic-field-on-bone-healing-around-endosseous-implants-an-in-vivo-study
#14
Mahalakshmi Gujjalapudi, Chandrasekar Anam, Praveen Mamidi, Radha Chiluka, A Gautam Kumar, Ragini Bibinagar
INTRODUCTION: After implant placement, a stress-free healing period of 3-6 months is a pre-requisite to achieve good osseointegration. If this duration could be reduced, the patients would feel happier. Eventhough, immediate loading of implants is a clinically feasible concept; it is not possible in certain situations. Few studies have shown that Static magnetic field is useful to promote bone formation faster after the bone is wounded. AIM: This pilot study was intended to evaluate the tissue response after implant placement under the influence of magnetic field...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27886544/3-aroylindoles-display-antitumor-activity-in%C3%A2-vitro-and-in%C3%A2-vivo-effects-of-n1-substituents-on-biological-activity
#15
Hsueh-Yun Lee, Jiann-Fong Lee, Sunil Kumar, Yi-Wen Wu, Wei-Chun HuangFu, Mei-Jung Lai, Yu-Hsuan Li, Hsiang-Ling Huang, Fei-Chiao Kuo, Che-Jen Hsiao, Chun-Chun Cheng, Chia-Ron Yang, Jing-Ping Liou
A series of 3-aroylindole hydroxamic acids (10-17) were developed based on the concept of a structural combination of tubulin and histone deacetylase (HDAC) inhibitors. This was accomplished by introducing hydroxamic acid-containing moieties at the N1 position of the tubulin assembly inhibitor, compound 9 (SCB01A, BPR0L075, phase II trial). Most of synthetic compounds produced in this way displayed comparable HDAC inhibitory activity, and four (10, 12-14) of them also inhibit tubulin assembly. Notably, compound 12 possesses not only tubulin and HDAC inhibitory activity but also shows HDAC6 selectivity over other HDAC isoforms...
January 5, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27855425/prostitution-as-a-psychiatric-situation-ethical-aspects
#16
Danijela Tiosavljević, Slavica Djukić-Dejanović, Karel Turza, Aleksandar Jovanović, Vida Jeremić
This paper presents the morally controversial phenomenon of prostitution. As the basis for contemplating the prostitution issue the most important is revealing and understanding its primitive ethical root. For understanding its "soul", its essence, also important is comprehending sexual, "elementary thoughts" of mankind, through the relationship between prostitution and religious, social, political and spiritual life, and its nature as a reflection of the sexual-ethical concepts in different epochs and nations...
December 2016: Psychiatria Danubina
https://www.readbyqxmd.com/read/27824616/increased-rates-of-cesarean-sections-and-large-families-a-potentially-dangerous-combination
#17
Ahmed M Saleh, Joachim W Dudenhausen, Badreldeen Ahmed
Rates of cesarean sections have been on the rise over the past three decades all over the world, despite the ideal rate of 10-15% that had been set by the World Health Organization (WHO) in 1985, in Fortaleza, Brazil. This epidemic increase in the rate of cesarean delivery is due to many factors which include, cesarean delivery on request, advanced maternal age at first pregnancy, decrease in number of patients who are willing to try vaginal birth after cesarean delivery, virtual disappearance of vaginal breech delivery, perceived increase in the weight of the fetus and increase in the number of women with chronic medical conditions such as Diabetes Mellitus and congenital heart disease in the reproductive age...
November 8, 2016: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/27807792/emtonjeni-a-structural-intervention-to-integrate-sexual-and-reproductive-health-into-public-sector-hiv-care-in-cape-town-south-africa-results-of-a-phase-ii-study
#18
J E Mantell, D Cooper, T M Exner, J Moodley, S Hoffman, L Myer, C-S Leu, D Bai, E A Kelvin, K Jennings, Z A Stein, D Constant, V Zweigenthal, N Cishe, N Nywagi
Integration of sexual and reproductive health within HIV care services is a promising strategy for increasing access to family planning and STI services and reducing unwanted pregnancies, perinatal HIV transmission and maternal and infant mortality among people living with HIV and their partners. We conducted a Phase II randomized futility trial of a multi-level intervention to increase adherence to safer sex guidelines among those wishing to avoid pregnancy and adherence to safer conception guidelines among those seeking conception in newly-diagnosed HIV-positive persons in four public-sector HIV clinics in Cape Town...
November 2, 2016: AIDS and Behavior
https://www.readbyqxmd.com/read/27789611/reviewing-the-focus-a-summary-and-critique-of-child-focused-sexual-abuse-prevention
#19
Julia Rudolph, Melanie J Zimmer-Gembeck
Due to the high incidence, and widespread detrimental health consequences, of child sexual abuse (CSA), effective prevention remains at the forefront of public and mental health research, prevention and intervention agendas. To date much of the focus of prevention has been on school-based education programs designed to teach children skills to evade adult sexual advances, and disclose past or ongoing abuse. Evaluation of sexual abuse prevention programs demonstrate their effectiveness in increasing children's knowledge of CSA concepts and protection skills, but little is known about their effects on children's capacity to prevent abuse...
October 26, 2016: Trauma, Violence & Abuse
https://www.readbyqxmd.com/read/27786600/novel-multispecific-heterodimeric-antibody-format-allowing-modular-assembly-of-variable-domain-fragments
#20
Timothy J Egan, Dania Diem, Richard Weldon, Tessa Neumann, Sebastian Meyer, David M Urech
Multispecific antibody formats provide a promising platform for the development of novel therapeutic concepts that could facilitate the generation of safer, more effective pharmaceuticals. However, the production and use of such antibody-based multispecifics is often made complicated by: 1) the instability of the antibody fragments of which they consist, 2) undesired inter-subunit associations, and 3) the need to include recombinant heterodimerization domains that confer distribution-impairing bulk or enhance immunogenicity...
October 27, 2016: MAbs
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