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https://www.readbyqxmd.com/read/27915360/patient-safety-organizations-and-emergency-medical-services
#1
William J Leggio, Lee Varner, Kathryn Wire
Providing safe and error-free patient care should resonate well with all healthcare providers including emergency medical technicians. The environments and circumstances in which emergency medical services (EMS) provide patient care inevitably create risks to both the provider and patient. This article explores the concepts of patient safety, errors, near misses, adverse events, and Just Culture. Literature raises concerns about the lack of data collection on both patient and provider safety and research on these safety topics in EMS...
2016: Journal of Allied Health
https://www.readbyqxmd.com/read/27906009/current-trends-and-intricacies-in-the-management-of-hiv-associated-pulmonary-tuberculosis
#2
REVIEW
Narendran Gopalan, Padmapriyadarsini Chandrasekaran, Soumya Swaminathan, Srikanth Tripathy
Human immunodeficiency virus (HIV) epidemic has undoubtedly increased the incidence of tuberculosis (TB) globally, posing a formidable global health challenge affecting 1.2 million cases. Pulmonary TB assumes utmost significance in the programmatic perspective as it is readily transmissible as well as easily diagnosable. HIV complicates every aspect of pulmonary tuberculosis from diagnosis to treatment, demanding a different approach to effectively tackle both the diseases. In order to control these converging epidemics, it is important to diagnose early, initiate appropriate therapy for both infections, prevent transmission and administer preventive therapy...
September 26, 2016: AIDS Research and Therapy
https://www.readbyqxmd.com/read/27891492/effect-of-magnetic-field-on-bone-healing-around-endosseous-implants-an-in-vivo-study
#3
Mahalakshmi Gujjalapudi, Chandrasekar Anam, Praveen Mamidi, Radha Chiluka, A Gautam Kumar, Ragini Bibinagar
INTRODUCTION: After implant placement, a stress-free healing period of 3-6 months is a pre-requisite to achieve good osseointegration. If this duration could be reduced, the patients would feel happier. Eventhough, immediate loading of implants is a clinically feasible concept; it is not possible in certain situations. Few studies have shown that Static magnetic field is useful to promote bone formation faster after the bone is wounded. AIM: This pilot study was intended to evaluate the tissue response after implant placement under the influence of magnetic field...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27886544/3-aroylindoles-display-antitumor-activity-in%C3%A2-vitro-and-in%C3%A2-vivo-effects-of-n1-substituents-on-biological-activity
#4
Hsueh-Yun Lee, Jiann-Fong Lee, Sunil Kumar, Yi-Wen Wu, Wei-Chun HuangFu, Mei-Jung Lai, Yu-Hsuan Li, Hsiang-Ling Huang, Fei-Chiao Kuo, Che-Jen Hsiao, Chun-Chun Cheng, Chia-Ron Yang, Jing-Ping Liou
A series of 3-aroylindole hydroxamic acids (10-17) were developed based on the concept of a structural combination of tubulin and histone deacetylase (HDAC) inhibitors. This was accomplished by introducing hydroxamic acid-containing moieties at the N1 position of the tubulin assembly inhibitor, compound 9 (SCB01A, BPR0L075, phase II trial). Most of synthetic compounds produced in this way displayed comparable HDAC inhibitory activity, and four (10, 12-14) of them also inhibit tubulin assembly. Notably, compound 12 possesses not only tubulin and HDAC inhibitory activity but also shows HDAC6 selectivity over other HDAC isoforms...
November 15, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27855425/prostitution-as-a-psychiatric-situation-ethical-aspects
#5
Danijela Tiosavljević, Slavica Djukić-Dejanović, Karel Turza, Aleksandar Jovanović, Vida Jeremić
This paper presents the morally controversial phenomenon of prostitution. As the basis for contemplating the prostitution issue the most important is revealing and understanding its primitive ethical root. For understanding its "soul", its essence, also important is comprehending sexual, "elementary thoughts" of mankind, through the relationship between prostitution and religious, social, political and spiritual life, and its nature as a reflection of the sexual-ethical concepts in different epochs and nations...
December 2016: Psychiatria Danubina
https://www.readbyqxmd.com/read/27824616/increased-rates-of-cesarean-sections-and-large-families-a-potentially-dangerous-combination
#6
Ahmed M Saleh, Joachim W Dudenhausen, Badreldeen Ahmed
Rates of cesarean sections have been on the rise over the past three decades all over the world, despite the ideal rate of 10-15% that had been set by the World Health Organization (WHO) in 1985, in Fortaleza, Brazil. This epidemic increase in the rate of cesarean delivery is due to many factors which include, cesarean delivery on request, advanced maternal age at first pregnancy, decrease in number of patients who are willing to try vaginal birth after cesarean delivery, virtual disappearance of vaginal breech delivery, perceived increase in the weight of the fetus and increase in the number of women with chronic medical conditions such as Diabetes Mellitus and congenital heart disease in the reproductive age...
November 8, 2016: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/27807792/emtonjeni-a-structural-intervention-to-integrate-sexual-and-reproductive-health-into-public-sector-hiv-care-in-cape-town-south-africa-results-of-a-phase-ii-study
#7
J E Mantell, D Cooper, T M Exner, J Moodley, S Hoffman, L Myer, C-S Leu, D Bai, E A Kelvin, K Jennings, Z A Stein, D Constant, V Zweigenthal, N Cishe, N Nywagi
Integration of sexual and reproductive health within HIV care services is a promising strategy for increasing access to family planning and STI services and reducing unwanted pregnancies, perinatal HIV transmission and maternal and infant mortality among people living with HIV and their partners. We conducted a Phase II randomized futility trial of a multi-level intervention to increase adherence to safer sex guidelines among those wishing to avoid pregnancy and adherence to safer conception guidelines among those seeking conception in newly-diagnosed HIV-positive persons in four public-sector HIV clinics in Cape Town...
November 2, 2016: AIDS and Behavior
https://www.readbyqxmd.com/read/27789611/reviewing-the-focus-a-summary-and-critique-of-child-focused-sexual-abuse-prevention
#8
Julia Rudolph, Melanie J Zimmer-Gembeck
Due to the high incidence, and widespread detrimental health consequences, of child sexual abuse (CSA), effective prevention remains at the forefront of public and mental health research, prevention and intervention agendas. To date much of the focus of prevention has been on school-based education programs designed to teach children skills to evade adult sexual advances, and disclose past or ongoing abuse. Evaluation of sexual abuse prevention programs demonstrate their effectiveness in increasing children's knowledge of CSA concepts and protection skills, but little is known about their effects on children's capacity to prevent abuse...
October 26, 2016: Trauma, Violence & Abuse
https://www.readbyqxmd.com/read/27786600/novel-multispecific-heterodimeric-antibody-format-allowing-modular-assembly-of-variable-domain-fragments
#9
Timothy J Egan, Dania Diem, Richard Weldon, Tessa Neumann, Sebastian Meyer, David M Urech
Multispecific antibody formats provide a promising platform for the development of novel therapeutic concepts that could facilitate the generation of safer, more effective pharmaceuticals. However, the production and use of such antibody-based multispecifics is often made complicated by: 1) the instability of the antibody fragments of which they consist, 2) undesired inter-subunit associations, and 3) the need to include recombinant heterodimerization domains that confer distribution-impairing bulk or enhance immunogenicity...
October 27, 2016: MAbs
https://www.readbyqxmd.com/read/27736848/can-team-training-make-surgery-safer-lessons-for-national-implementation-of-a-simulation-based-programme
#10
Jennifer Weller, Ian Civil, Jane Torrie, David Cumin, Alexander Garden, Arden Corter, Alan Merry
AIM: Unintended patient harm is a major contributor to poor outcomes for surgical patients and often reflects failures in teamwork. To address this we developed a Multidisciplinary Operating Room Simulation (MORSim) intervention to improve teamwork in the operating room (OR) and piloted it with 20 OR teams in two of the 20 District Health Boards in New Zealand prior to national implementation. In this study, we describe the experience of those exposed to the intervention, challenges to implementing changes in clinical practice and suggestions for successful implementation of the programme at a regional or national level...
October 14, 2016: New Zealand Medical Journal
https://www.readbyqxmd.com/read/27729657/the-gut-microbiota-and-gastrointestinal-surgery
#11
REVIEW
Kristina Guyton, John C Alverdy
Surgery involving the gastrointestinal tract continues to prove challenging because of the persistence of unpredictable complications such as anastomotic leakage and life-threatening infections. Removal of diseased intestinal segments results in substantial catabolic stress and might require complex reconstructive surgery to maintain the functional continuity of the intestinal tract. As gastrointestinal surgery necessarily involves a breach of an epithelial barrier colonized by microorganisms, preoperative intestinal antisepsis is used to reduce infection-related complications...
October 12, 2016: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27708678/current-trends-and-intricacies-in-the-management-of-hiv-associated-pulmonary-tuberculosis
#12
Narendran Gopalan, Padmapriyadarsini Chandrasekaran, Soumya Swaminathan, Srikanth Tripathy
Human immunodeficiency virus (HIV) epidemic has undoubtedly increased the incidence of tuberculosis (TB) globally, posing a formidable global health challenge affecting 1.2 million cases. Pulmonary TB assumes utmost significance in the programmatic perspective as it is readily transmissible as well as easily diagnosable. HIV complicates every aspect of pulmonary tuberculosis from diagnosis to treatment, demanding a different approach to effectively tackle both the diseases. In order to control these converging epidemics, it is important to diagnose early, initiate appropriate therapy for both infections, prevent transmission and administer preventive therapy...
2016: AIDS Research and Therapy
https://www.readbyqxmd.com/read/27699644/chronotherapy-intuitive-sound-founded%C3%A2-but-not-broadly-applied
#13
Julia M Selfridge, Tetsuya Gotoh, Samuel Schiffhauer, JingJing Liu, Philip E Stauffer, Andrew Li, Daniel G S Capelluto, Carla V Finkielstein
Circadian rhythms are a collection of endogenously driven biochemical, physiological, and behavioral processes that oscillate in a 24-h cycle and can be entrained by external cues. Circadian clock molecules are responsible for the expression of regulatory components that modulate, among others, the cell's metabolism and energy consumption. In clinical practice, the regulation of clock mechanisms is relevant to biotransformation of therapeutics. Accordingly, xenobiotic metabolism and detoxification, the two processes that directly influence drug effectiveness and toxicity, are direct manifestations of the daily oscillations of the cellular and biochemical processes taking place within the gastrointestinal, hepatic/biliary, and renal/urologic systems...
October 3, 2016: Drugs
https://www.readbyqxmd.com/read/27678783/removal-of-retained-products-of-conception-using-a-hysteroscopic-morcellator-a-safer-alternative
#14
J C Petrozza
No abstract text is available yet for this article.
November 2015: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27676651/rituximab-in-membranous-nephropathy-not-all-studies-are-created-equal
#15
Paolo Cravedi
Many prospective studies and a recent randomized controlled trial have shown that the B-cell-depleting monoclonal antibody, rituximab, safely promotes the remission of nephrotic syndrome in approximately 65% of patients with membranous nephropathy (MN). Mechanistic studies have indicated that rituximab-induced proteinuria reduction is associated with clearance of anti-podocyte antigens phospholipase 2 receptor autoantibodies and subepithelial immune complexes, the hallmarks of the disease. A recently published study reported results which, at first sight, looked less favorable and implied that, due to a publication bias against negative results, the efficacy of rituximab in MN might be overestimated...
September 28, 2016: Nephron
https://www.readbyqxmd.com/read/27639743/a-new-transcatheter-heart-valve-concept-the-triskele-feasibility-in-an-acute-preclinical-model
#16
Benyamin Rahmani, Spyros Tzamtzis, Rose Sheridan, Michael J Mullen, John Yap, Alexander M Seifalian, Gaetano Burriesci
AIMS: The aim of this study was to introduce and demonstrate the feasibility in an acute preclinical model of a new transcatheter heart valve concept with a self-expanding wire frame, polymeric leaflets and a sealing component. METHODS AND RESULTS: The TRISKELE valve was developed based on a previously validated polymeric leaflet design, an adaptive sealing cuff and a novel nitinol wire frame which reduces stress on the leaflets and radial pressure on the surrounding tissue...
September 18, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27639666/-total-en-bloc-spondylectomy-for-spinal-tumours-technical-aspects-and-surgical-details
#17
Pedro David Delgado-López, Antonio Rodríguez-Salazar, Vicente Martín-Velasco, José Manuel Castilla-Díez, Javier Martín-Alonso, Ana Galacho-Harriero, Cecilia Gil-Polo, Elena Araus-Galdós
OBJECTIVE: To describe the specific surgical details and report the lessons learned with a series of patients suffering from spinal tumours that underwent total en bloc spondylectomy (TES). METHODS: A retrospective case series review is presented, together with an analysis of the clinical and technical variables, as well as the outcomes. RESULTS: A total of 10 patients underwent TES (2000-2016) for primary (osteosarcoma, chondrosarcoma, fibrosarcoma and chordoma) and secondary spinal tumours (lung, breast, thyroid, oesophagus, and meningioma metastases)...
September 14, 2016: Neurocirugía
https://www.readbyqxmd.com/read/27636539/study-of-the-impact-of-the-location-of-a-perforator-in-the-perfusion-of-a-perforator-flap-the-concept-of-angle-of-perfusion
#18
Alexis T Laungani, Jodie Christner, Jason A Primus, Nirusha Lachman, Karla V Ballman, Anita Mohan, Michel Saint-Cyr
Background Perforator flaps remain challenging in their design, especially as free flaps. We used a cadaveric model to help refine the design of perforator flaps by studying their vascular features. We define the angle of perfusion of a perforator as a tool to achieve safer flap designs. Methods A total of 83 flaps were designed from 20 fresh cadaveric anterolateral thigh flaps. The most dominant perforator larger than 0.5 mm was used as the reference point on the midline of the flap, and the tip of the flap was set at 5 cm (n = 10), 2 cm (n = 5), or 10 cm (n = 5) from this perforator...
September 16, 2016: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/27625225/is-outpatient-brain-tumor-surgery-feasible-in-india
#19
REVIEW
Mazda K Turel, Mark Bernstein
The current trend in all fields of surgery is towards less invasive procedures with shorter hospital stays. The reasons for this change include convenience to patients, optimal resource utilization, and cost saving. Technological advances in neurosurgery, aided by improvements in anesthesia, have resulted in surgery that is faster, simpler, and safer with excellent perioperative recovery. As a result of improved outcomes, some centers are performing brain tumor surgery on an outpatient basis, wherein patients arrive at the hospital the morning of their procedure and leave the hospital the same evening, thus avoiding an overnight stay in the hospital...
September 2016: Neurology India
https://www.readbyqxmd.com/read/27610626/fertility-desires-among-women-living-with-hiv
#20
Deborah Lynne Jones, Ryan Cook, JoNell Efantis Potter, Talya Miron-Shatz, Nahida Chakhtoura, Andrew Spence, Margaret M Byrne
OBJECTIVE: Rates of pregnancy among women living with HIV (WLHIV) have increased with the availability of effective HIV treatment. Planning for pregnancy and childbirth is an increasingly important element of HIV care. Though rates of unintended pregnancies are high among women in general, among couples affected by HIV, significant planning and reproductive decisions must be considered to prevent negative health consequences for WLHIV and their neonates. To gain insight into this reproductive decision-making process among WLHIV, this study explored women's knowledge, attitudes and practices regarding fertility planning, reproductive desires, and safer conception practices...
2016: PloS One
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