Yueping Zhang, Petia A Shipkova, Bethanne M Warrack, David M Nelson, Linna Wang, Runlan Huo, Jian Chen, Erika Panfen, Xue-Qing Chen, Marcus Fancher, Qian Ruan, Lisa J Christopher, Yongjun Xue, Michael Sinz, Hong Shen
Advancement of endogenous biomarkers for drug transporters as a tool for assessing drug-drug interactions (DDIs) depends on initial identification of biomarker candidates and relies heavily on biomarker validation and its response to reference inhibitors in vivo. To identify endogenous biomarkers of breast cancer resistance protein (BCRP), we applied metabolomic approaches to profile plasma from Bcrp-/-, Mdr1a/1b-/-, and Bcrp/Mdr1a/1b-/- mice. Approximately 130 metabolites were significantly altered in Bcrp and P-gp knockout mice, indicating numerous metabolite-transporter interactions...
April 13, 2023: Drug Metabolism and Disposition: the Biological Fate of Chemicals