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https://www.readbyqxmd.com/read/29667385/chance-of-reimbursement-for-add-on-therapies-in-poland-and-in-the-world-review-of-the-reimbursement-recommendations
#1
Ewa Borowiack, Magdalena Marzec, Anna Nowotarska, Joanna Jarosz, Agata Orkisz, Patrycja Prząda-Machno
INTRODUCTION: Oncology drugs combined with standard therapies (so-called add-on therapies, e.g. bevacizumab, palbociclib) often receive negative recommendations regarding the legitimacy of public financing, issued by government agencies responsible for their assessment, i.e. health technology assessment agencies. The aim of the study was to estimate the scale of the problem related to the reimbursement of add-on therapies used in the treatment of breast and genitourinary cancers in Poland and in the world...
2018: Przegla̧d Epidemiologiczny
https://www.readbyqxmd.com/read/29664842/incidental-thoracic-findings-on-routine-computed-tomography-in-epithelial-ovarian-cancer
#2
Bobby D OʼLeary, Teresa Treacy, Tony Geoghegan, Tom A Walsh, William D Boyd, Donal J Brennan
INTRODUCTION: Multidetector computed tomography (MDCT) is routinely used in the surveillance of epithelial ovarian cancer. The aim of this study was to determine the incidence of thoracic findings on routine MDCT surveillance imaging in patients with ovarian carcinoma. MATERIALS AND METHODS: Retrospective evaluation of 100 MDCT studies of patients with a diagnosis of epithelial ovarian cancer was performed at a university teaching hospital. The cross-sectional studies were reviewed by a consultant radiologist with subspeciality training in cross-sectional imaging...
April 16, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29623275/wilms-tumor-protein-1-and-enzymatic-oxidation-of-5-methylcytosine-in-brain-tumors-potential-perspectives
#3
REVIEW
Ashley Ramsawhook, Alexey Ruzov, Beth Coyle
The patterns of 5-methylcytosine (5mC) and its oxidized derivatives, 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxylcytosine (5caC) are reportedly altered in a range of cancers. Likewise, Wilms' Tumor protein 1 (WT1), a transcription factor essential for urogenital, epicardium, and kidney development exhibits aberrant expression in multiple tumors. Interestingly, WT1 directly interacts with TET proteins that catalyze the enzymatic oxidation of 5mC and exhibits high affinity for 5caC-containing DNA substrates in vitro ...
2018: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/29602840/vitamin-d-obesity-and-leptin-in-relation-to-bladder-cancer-incidence-and-survival-prospective-protocol-study
#4
Randi Elin Gislefoss, Jo Steinson Stenehjem, Helga Helseth Hektoen, Bettina Kulle Andreassen, Hilde Langseth, Karol Axcrona, Elisabete Weiderpass, Alison Mondul, Trude Eid Robsahm
INTRODUCTION: Bladder cancer (BC) (including renal pelvis, ureter and urethra) is one of the most common urogenital cancers and the fourth most frequent cancer in men in the USA. In Norway, the incidence of BC has increased over the last decades. The age-standardised incidence rates per 100 000 for 2011-2015 were 53.7 in men and 16.5 in women. Compared to the 5-year period 2006-2010, the percentage increase in incidence was 6.1% in men and 12.3% in women. The recurrence rate of BC is over 50%, the highest recurrence rate of any malignancy...
March 30, 2018: BMJ Open
https://www.readbyqxmd.com/read/29596925/association-of-pesticide-exposure-with-human-congenital-abnormalities
#5
REVIEW
Charikleia Kalliora, Charalampos Mamoulakis, Eleni Vasilopoulos, George A Stamatiades, Lydia Kalafati, Roza Barouni, Triantafyllia Karakousi, Mohammad Abdollahi, Aristidis Tsatsakis
Human pesticide exposure can occur both occupationally and environmentally during manufacture and after the application of indoor and outdoor pesticides, as well as through consumption via residues in food and water. There is evidence from experimental studies that numerous pesticides, either in isolation or in combination, act as endocrine disruptors, neurodevelopmental toxicants, immunotoxicants, and carcinogens. We reviewed the international literature on this subject for the years between 1990 and 2017...
March 26, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29570254/diagnostic-accuracy-of-multiparametric-magnetic-resonance-imaging-in-detecting-extracapsular-extension-in-intermediate-and-high-risk-prostate-cancer
#6
Cristina Dominguez, Mauricio Plata, Juan Guillermo Cataño, Mauricio Palau, Diego Aguirre, Jorge Narvaez, Stephanie Trujillo, Felipe Gómez, Carlos Gustavo Trujillo, Juan Ignacio Caicedo, Camilo Medina
OBJECTIVES: To evaluate the diagnostic performance of preoperative multiparametric magnetic resonance imaging (mp-MRI) as a predictor of extracapsular extension (ECE) and unfavorable Gleason score (GS) in patients with intermediate and high-risk prostate cancer (PCa). MATERIALS AND METHODS: Patients with clinically localized PCa who underwent radical prostatectomy (RP) and had preoperative mp-MRI between May-2011 and December-2013. Mp-MRI was evaluated according to the European Society of Urogenital Radiology MRI prostate guidelines by two different readers...
March 23, 2018: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29541570/two-cases-of-myiasis-associated-with-malignancies-in-patients-living-in-the-continental-united-states
#7
Anita Lwanga, Michael Anis, Mohamed Ayoubi, Jaya Sharma, Pam Khosla
Myiasis is the infestation of humans with dipterous larvae. Traditionally, myiasis was thought to affect individuals living in tropical regions, however, several cases in temperate zones have been reported. We encountered two patients with histories of malignancies that presented with complaints of myiasis, in Chicago, in the spring and summer of 2016. The first patient, a 54-year-old female with a history of breast cancer, presented with complaints of maggots infesting her postsurgical chest wounds. She was diagnosed with sepsis, cellulitis, and wound myiasis...
January 10, 2018: Curēus
https://www.readbyqxmd.com/read/29540105/clotassist-a-program-to-treat-cancer-associated-thrombosis-in-an-outpatient-pharmacy-setting
#8
Jacob C Easaw, Susan McCall, Adrian Azim
Stable cancer patients diagnosed with a pulmonary embolus or deep vein thrombosis are commonly referred to the emergency department for management. This practice strains an already overburdened emergency department and is associated with long wait times and poor disease/injection education for patients. This pilot study sought to determine if stable cancer patients with newly diagnosed cancer-associated thrombosis could be effectively managed by community-based pharmacists who followed an evidence-based protocol to prescribe and initiate low-molecular weight heparin therapy...
January 1, 2018: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/29509256/up-regulation-of-mir-190b-promoted-growth-invasion-migration-and-inhibited-apoptosis-of-wilms-tumor-cells-by-repressing-the-pten-expression
#9
N-N An, J Shawn, J-P Peng, M-D Wu, L-G Huang
OBJECTIVE: Wilms' tumor (WT) is the most common malignant tumor in the children's urogenital system. MiR-190b was found to participate in the development and progression of several cancers. However, the molecular mechanism of miR-190b in WT is still unclear. PATIENTS AND METHODS: We detected the miR-190b in WT tissue samples compared to adjacent normal samples as well as in WT patients' blood sample compared to normal volunteers using qRT-PCR. With over-expression and knockdown of miR-190b in WT-derived cell line SK-NEP-1, we next studied cell proliferation, cell circle, apoptosis, invasion and migration abilities change caused by miR-190b ectopic expression...
February 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29507850/cyberknife-stereotactic-radiosurgery-for-primary-and-metastatic-cancer-in-the-cervix
#10
Yuko Harada, Shinichiro Miyazaki
Standard radiation therapy for cervical cancer consists of external beam radiation therapy followed by an intracavitary brachytherapy boost. When brachytherapy cannot be performed due to unfavorable anatomy or coexisting medical conditions, stereotactic body radiotherapy with the CyberKnife is another treatment option which is less invasive and can be performed in a shorter treatment time. We performed non-invasive therapy using the CyberKnife for five cases of urogenital cancer located in the cervix. The local tumor control was excellent with minimal toxicity...
December 29, 2017: Curēus
https://www.readbyqxmd.com/read/29498901/prevalence-of-urogenital-carcinoma-in-stranded-california-sea-lions-zalophus-californianus-from-2005-2015
#11
Alissa C Deming, Kathleen M Colegrove, Padraig J Duignan, Ailsa J Hall, James F X Wellehan, Frances M D Gulland
Urogenital carcinoma is common in wild California sea lions ( Zalophus californianus) along the west coast of the US. From 1979 to 1994, this cancer was observed in 18% (66/370) of necropsied subadult and adult sea lions at The Marine Mammal Center in Sausalito, California. A retrospective review of records from 1 January 2005 to 31 December 2015 was performed to characterize prevalence and characteristics of cancer over this decade. Fourteen percent (263/1917) of necropsied sea lions had cancer, of which 90% (237/263) were urogenital carcinoma...
March 2, 2018: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/29461594/the-impact-of-nudcd1-on-renal-carcinoma-cell-proliferation-migration-and-invasion
#12
R-J Wang, N Wang, G Cui, Y Chen, H Zhong, J Tang
OBJECTIVE: Renal cell carcinoma (RCC) is the most common malignant tumor in the urogenital system. Its easily metastatic characteristics greatly reduce the postoperative survival rate. NudCD1, as a proto-oncogene, may be involved in the proliferation, migration, and invasion of renal cell carcinoma cell. This study intends to explore the expression of NudCD1 in renal cancer tissue and its effect on renal cell behavior. PATIENTS AND METHODS: NudCD1 expression in RCC tissue was tested Western blot...
February 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29436852/comparing-photon-and-proton-based-hypofractioned-sbrt-for-prostate-cancer-accounting-for-robustness-and-realistic-treatment-deliverability
#13
Lee Goddard, Nils P Brodin, William R Bodner, Madhur Garg, Wolfgang A Tomé
OBJECTIVE: To investigate whether photon or proton based SBRT is the preferred modality for high dose hypofractionation prostate cancer treatment. Achievable dose distributions were compared when uncertainties in target positioning and range uncertainties were appropriately accounted for. METHODS: Ten patients with prostate cancer previously treated at our institution with photon SBRT using volumetric modulated arc therapy (VMAT) were identified. MRI images fused to the treatment planning CT allowed for accurate target and organ-at-risk (OAR) delineation...
February 13, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29315701/histological-and-quantitative-analyzes-of-the-stromal-and-acinar-components-of-normal-human-prostate-zones
#14
Edilaine F Alves, Bruno Leonardo M de Freitas Ribeiro, Waldemar S Costa, Carla B M Gallo, Francisco J B Sampaio
BACKGROUND: McNeal divided the human prostate into three major anatomical areas: the peripheral zone (PZ), the central zone (CZ), and the transition zone (TZ). Each of these areas is biologically and histologically distinct. The PZ and TZ have clinical significance and are associated with prostate cancer (PC) and benign prostatic hyperplasia (BPH), respectively. Therefore, the objective of the present study was to quantitatively and qualitatively analyze the parenchymal and stromal components that constitute the different prostate zones...
March 2018: Prostate
https://www.readbyqxmd.com/read/29273076/highly-conformal-combined-radiotherapy-with-cisplatin-and-gemcitabine-for-treatment-of-loco-regionally-advanced-cervical-cancer-a-retrospective-study
#15
Nikola Cihoric, Alexandros Tsikkinis, Eugenia Vlaskou Badra, Markus Glatzer, Urban Novak, Amina Scherz, Mohamed Shelan, Ivan Soldatovic, Chittazhathu Kurian Kuruvilla Yojena, Daniel M Aebersold, Kristina Lössl
BACKGROUND: Cisplatin and gemcitabine combined with conventional radiation therapy in the treatment of cervical cancer patients results in a favorable outcome but with excess toxicity. The purpose of this study was to evaluate the toxicity profile of dual chemotherapy and highly conformal external beam radiotherapy with image guided adaptive brachytherapy. METHODS: Seventeen patients with cervical carcinoma FIGO stage IB2-IIIB were treated with curative intent between 2011 and 2015...
December 22, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/29250970/-image-guided-radiotherapy-for-muscle-invasive-bladder-cancer-with-intravesical-lipiodol-injection-a-new-option-for-bladder-sparing-treatment
#16
Jorgo Kliton, Csaba Polgár, Péter Tenke, Gábor Kovács, Tibor Major, Gábor Stelczer, Péter Ágoston
INTRODUCTION AND AIM: To implement lipiodol as a fiducial marker of the tumor bed for image-guided radiotherapy with simultaneous integrated boost technique as part of radiochemotherapy for muscle invasive bladder tumors. METHOD: Since April 2016, radiochemotherapy was performed in 3 male patients with muscle invasive, transitional cell bladder carcinoma. Prior to radiochemotherapy, tumor bed resection was performed for each patient, at the same time 10 ml of lipiodol solution was injected submucosally into the resection site, thus marking the tumor bed for escalated dose irradiation...
December 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/29250197/antiangiogenic-therapies-in-urogenital-malignancies-fiction-or-fact
#17
REVIEW
Friederike Haidl, David Pfister, Axel Heidenreich, Isabel Heidegger
The use of antiangiogenic agents in cancer therapy has become an attractive target in oncological research. However, concerning the uro-oncological field, current guidelines only recommend the use of antiangiogenic agents in metastatic renal cell cancer. Yet in recent years, several approaches for sequential treatment with angiogenesis inhibitors in other urogenital malignancies apart from renal cell cancer are ongoing. Thus, the present review article aims to provide an overview about clinical studies with antiangiogenic agents in prostate-, bladder-, testicular-, as well as penile cancer patients...
2017: Memo
https://www.readbyqxmd.com/read/29218255/oncology-section-edge-task-force-on-urogenital-cancer-a-systematic-review-of-clinical-measures-for-incontinence
#18
Alicia Jeffrey, Shana E Harrington, Alexandra Hill, Amanda Roscow, Meryl Alappattu
Background: Compared to the general population, women and men with urogenital and colorectal cancer experience higher rates of urinary and fecal incontinence. Although a variety of measures exist to assess these areas, currently, there are no guidelines recommending which outcomes rehabilitation professionals should administer to examine these impairments in those with cancer. Purpose: To identify outcome measures for assessing urinary and fecal incontinence and evaluate their psychometric data and applicability to the cancer population...
July 2017: Rehabilitation Oncology
https://www.readbyqxmd.com/read/29207728/the-effect-of-soy-isoflavones-on-the-menopause-rating-scale-scoring-in-perimenopausal-and-postmenopausal-women-a-pilot-study
#19
Marya Ahsan, Ayaz Khurram Mallick
Introduction: Menopause is associated with many unpleasant symptoms which vary in different phases of menopausal transition. Although, Hormone Replacement Therapy (HRT) is considered the most effective mode of treatment for these symptoms, its use is associated with increased risk of breast cancer, endometrial cancer and thromboembolic events. Soy isoflavones are being widely used as a safer alternative to HRT, even though scientific evidence of their efficacy is poor or lacking. Aim: To study the effect of soy isoflavone supplementation on the menopausal symptoms in perimenopausal and postmenopausal women...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29200869/preoperative-prognostic-nutritional-index-and-nomogram-predicting-recurrence-free-survival-in-patients-with-primary-non-muscle-invasive-bladder-cancer-without-carcinoma-in-situ
#20
Jianfeng Cui, Shouzhen Chen, Qiyu Bo, Shiyu Wang, Ning Zhang, Meng Yu, Wenfu Wang, Jie Han, Yaofeng Zhu, Benkang Shi
Background and objectives: Among the cancers of the urogenital system, bladder cancer is ranked second both in incidence and mortality, and hence, a more accurate estimate of the prognosis for individual patients with non-muscle-invasive bladder cancer (NMIBC) is urgently needed. Prognostic nutritional index (PNI) which is based on serum albumin levels and peripheral lymphocyte count has been confirmed to have prognostic value in various cancers. The aim of this study was to clarify the prognostic value of PNI in patients with NMIBC...
2017: OncoTargets and Therapy
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