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https://www.readbyqxmd.com/read/28797714/profiling-the-urinary-microbiome-in-men-with-positive-versus-negative-biopsies-for-prostate-cancer
#1
Eva Shrestha, James R White, Shu-Han Yu, Ibrahim Kulac, Onur Ertunc, Angelo M De Marzo, Srinivasan Yegnasubramanian, Leslie A Mangold, Alan W Partin, Karen S Sfanos
PURPOSE: Studies demonstrating bacterial DNA and cultivable bacteria in urine samples have challenged the clinical dogma that urine is sterile. Furthermore, studies now indicate that dysbiosis of the urinary microbiome is associated with pathological conditions. We propose that the urinary microbiome may influence chronic inflammation observed in the prostate, leading to prostate cancer development and progression. We therefore aimed to profile the urinary microbiome in men with positive versus negative biopsies for prostate cancer...
August 7, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28740634/human-papillomavirus-and-gastrointestinal-cancer-in-iranian-population-a-systematic-review-and-meta-analysis
#2
REVIEW
Versa Omrani-Navai, Reza Alizadeh-Navaei, Yousef Yahyapour, Akbar Hedayatizadeh-Omran, Saeid Abediankenari, Ghasem Janbabaei, Fatima Toghani
BACKGROUND: Gastrointestinal (GI) malignancies are the most common cancers and account for nearly half of all cancer-related deaths in Iran. There was a strong association between human papillomavirus (HPV) infection and urogenital cancers, in particular the cervix. However, there is no clear causal relationship in all types of cancers, including gastrointestinal cancers. Therefore, the present study as a systematic review and meta-analysis was designed to evaluate the prevalence and relation of HPV in GI cancers...
2017: Caspian Journal of Internal Medicine
https://www.readbyqxmd.com/read/28721448/-pi-rads-2-0-for-prostate-mri
#3
T Franiel, M Röthke
The PI-RADS 2.0 classification was established by an international collaboration of the European Society of Urogenital Radiology (ESUR), the American College of Radiology (ACR), and AdMetech Foundation to globally standardize the acquisition and interpretation of multiparametric prostate magnetic resonance imaging (MRI). The PI-RADS 2.0 aims to improve the detection, localization, staging and risk stratification of patients with suspected or histologically confirmed prostate cancer. Suspicious areas on T2-weighted (T2w) MRI, diffusion-weighted MRI (DWI) and dynamic contrast-enhanced MRI (DCE-MRI) were assessed for the presence of a clinically significant prostate cancer with scale from 1 to 5 with 5 being most likely to represent clinically significant prostate cancer...
August 2017: Der Radiologe
https://www.readbyqxmd.com/read/28705037/saffron-and-its-derivatives-crocin-crocetin-and-safranal-a-patent-review
#4
Maryam Rameshrad, Bibi Marjan Razavi, Hossein Hosseinzadeh
Saffron and its main components have traditionally been used as pharmaceutical agents. Current experimental research projects have also exhibited their applications in a wide spectrum of disorder treatments. Area covered: This review covers the demonstrated findings and patents on therapeutic/pharmaceutical properties of saffron and related derivatives, since 2000 to bold their outstanding merit on human health. An extensive literature review was performed in USP Patent, Patentscope, Espacenet and Google Patent in the field of CNS, cardiovascular, urogenital, dermatological and inflammatory disorders...
July 13, 2017: Expert Opinion on Therapeutic Patents
https://www.readbyqxmd.com/read/28683707/docetaxel-in-hormone-sensitive-advanced-prostate-cancer-genesis-sefh-evaluation-reporta
#5
Juan Carlos García de Paredes Esteban, Emilio Jesús Alegre Del Rey, Rocío Asensi Díez
Prostate cancer (PC) is the most common urogenital malignancy in older men and the second leading cause of death by cancer in men in Europe. Current therapeutic practice considers Androgen Deprivation Therapy (ADT) as first line treatment for clinically localized prostate cancer at high-risk, either locally advanced or metastatic. ADT can be achieved through orchiectomy (surgical castration), luteinizing hormone-releasing hormone (LHRH) agonists, or through complete androgen blockade (LHRH agonist combined with an anti-androgen)...
July 1, 2017: Farmacia Hospitalaria
https://www.readbyqxmd.com/read/28671173/metastatic-renal-carcinoid-to-skin-lungs-and-pancreas
#6
Hammad Arshad, Parth Rali, Khalid Malik
Carcinoid tumors rarely originate in the urogenital system. We represent a unique case of primary renal carcinoid tumor which was initially diagnosed as renal cell cancer and 10 years later correctly diagnosed as metastatic renal carcinoid.
July 2017: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/28645572/longitudinal-associations-between-mental-health-conditions-and-overactive-bladder-in-women-veterans
#7
Catherine S Bradley, Ingrid E Nygaard, Stephen L Hillis, James C Torner, Anne G Sadler
BACKGROUND: One in 5 recently deployed US women veterans report overactive bladder symptoms. Mental health conditions such as depression and anxiety commonly co-occur in women with overactive bladder, but temporal relationships between these outcomes have not been well studied, and the mechanism behind this association is unknown. The Women Veterans Urinary Health Study, a nationwide longitudinal study in recently deployed women veterans, was designed to better understand relationships between overactive bladder and mental health conditions...
June 20, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28643303/-application-of-fascia-orientation-of-pelvic-autonomic-nerve-preservation-in-rectal-cancer-surgery
#8
Xiaobo Liang, Yi Wang, Guolong Ma
Rectal cancer has become the second most common gastrointestinal tumor in our country. With the development of comprehensive treatment, the long-term survival rate of patients with rectal cancer has greatly increased, meanwhile, higher postoperative quality of life is required. But the genitourinary dysfunction which is mainly caused by intraoperative pelvic autonomic nerve damage haunts postoperative rectal cancer patients. Traditional pelvic autonomic nerve protection technology born in the 1980s only improves urogenital function in a part of postoperative patients...
June 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28626107/-molecular-basis-for-prostate-carcinogenesis
#9
Fangzhi Chen, Xiaokun Zhao
Prostate cancer is the most prevalent male urogenital malignancy. Androgen deprivation therapy is the principal method for initial treatment for the patients, but the majority of them will eventually develop progressive disease, a status called castration-resistant prostate carcinoma. Lots of susceptibility genes, tumor suppressor genes and oncogenes, and their variations relevant to the occurrence and development of prostate cancer have been revealed by the studies of molecular oncology. These findings on the molecular basis of prostate carcinogenesis will further improve the strategies on prevention, diagnosis and clinical management for prostate carcinoma...
May 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/28577732/-prospective-how-will-renal-prostatic-and-urothelial-tumours-be-treated-in-10%C3%A2-years
#10
REVIEW
Alain Toledano, Mayada Bourmech, Hanah Lamallem, Marc Bollet, Olivier Bauduceau, Pascal Pujol, Patrick Bloch, David Khayat
Forward thinking does not seek to predict the future, to unveil it as if it were already in existence, rather, its aim is to help us to construct it. Although today's epidemiological and therapeutic situations for urogenital tumours can evolve over the next 10 years, diagnostic and therapeutic methods, as well as the treatment and implementation of innovations, are already rapidly changing. Rather than reducing our prospective thinking to the therapeutic treatment of cancer only, we will aim at proposing a global sanitary vision that includes diagnosis, therapies, prevention, routine utilisation of technomedicine, genomics and even nanomedicine...
April 2017: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/28554813/impact-of-exopolysaccharides-epss-of-lactobacillus-gasseri-strains-isolated-from-human-vagina-on-cervical-tumor-cells-hela
#11
Tolga Sungur, Belma Aslim, Cagtay Karaaslan, Busra Aktas
Lactobacilli, commonly used as probiotics, have been shown to maintain vaginal health and contribute to host microbiota interaction. Exopolysaccharides (EPSs) produced by lactobacillus have been found to have an important role in probiotic activity; however, there is limited knowledge concerning their impact on cervical cancer and urogenital health. The objective of this study is to investigate and compare EPSs of L. gasseri strains (G10 and H15), isolated from a healthy human vagina, for their capability to inhibit cervical cancer cell (HeLa) growth and modulate immune response...
May 26, 2017: Anaerobe
https://www.readbyqxmd.com/read/28554330/rho-associated-protein-kinase-2-rock2-a-new-target-of-autoimmunity-in-paraneoplastic-encephalitis
#12
Stoyan Popkirov, Ilya Ayzenberg, Stefanie Hahn, Jan Bauer, Yvonne Denno, Nicole Rieckhoff, Christiane Radzimski, Volkmar H Hans, Sebastian Berg, Florian Roghmann, Joachim Noldus, Christian G Bien, Sabine Skodda, Jörg Wellmer, Winfried Stöcker, Christos Krogias, Ralf Gold, Uwe Schlegel, Christian Probst, Lars Komorowski, Ramona Miske, Ingo Kleiter
Onconeural antibodies are associated with cancer and paraneoplastic encephalitis. While their pathogenic role is still largely unknown, their high diagnostic value is undisputed. In this study we describe the discovery of a novel target of autoimmunity in an index case of paraneoplastic encephalitis associated with urogenital cancer.A 75-year-old man with a history of invasive bladder carcinoma 6 years ago with multiple recurrences and a newly discovered renal cell carcinoma presented with seizures and progressive cognitive decline followed by super-refractory status epilepticus...
May 29, 2017: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/28551083/the-effects-of-yoga-and-self-esteem-on-menopausal-symptoms-and-quality-of-life-in-breast-cancer-survivors-a-secondary-analysis-of-a-randomized-controlled-trial
#13
Anna K Koch, Sybille Rabsilber, Romy Lauche, Sherko Kümmel, Gustav Dobos, Jost Langhorst, Holger Cramer
OBJECTIVES: Previous research has found that yoga can enhance quality of life and ease menopausal symptoms of breast cancer survivors. The study examined whether self-esteem mediated the effects of yoga on quality of life, fatigue and menopausal symptoms, utilizing validated outcome measures. STUDY DESIGN: This is a secondary analysis of a randomized controlled trial comparing the effects of yoga with those of usual care in 40 breast cancer survivors who suffered from menopausal symptoms...
May 13, 2017: Maturitas
https://www.readbyqxmd.com/read/28544473/level-of-vascular-tie-and-its-effect-on-functional-outcome-two-years-after-anterior-resection-for-rectal-cancer
#14
Daniel Kverneng Hultberg, Ashkan A Afshar, Jörgen Rutegård, Marilyne Lange, Markku M Haapamäki, Peter Matthiessen, Martin Rutegård
AIM: Previous research indicates that high tie of the inferior mesenteric artery during anterior resection for rectal cancer might be associated with an increased risk of postoperative functional disturbances. The goal of this population-based retrospective cohort study was to further investigate that association. METHOD: Patients who underwent anterior resection for rectal cancer from April 2011-September 2012 were identified through the Swedish Colorectal Cancer Registry...
May 25, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/28524158/sequencing-of-dicer1-in-sarcomas-identifies-biallelic-somatic-dicer1-mutations-in-an-adult-onset-embryonal-rhabdomyosarcoma
#15
Leanne de Kock, Barbara Rivera, Timothée Revil, Paul Thorner, Catherine Goudie, Dorothée Bouron-Dal Soglio, Catherine S Choong, John R Priest, Paul J van Diest, Jantima Tanboon, Anja Wagner, Jiannis Ragoussis, Peter Fm Choong, William D Foulkes
BACKGROUND: Sarcomas are rare and heterogeneous cancers. We assessed the contribution of DICER1 mutations to sarcoma development. METHODS: The coding region of DICER1 was sequenced in 67 sarcomas using a custom Fluidigm Access Array. The RNase III domains were Sanger sequenced in six additional sarcomas to identify hotspot DICER1 variants. RESULTS: The median age of sarcoma diagnosis was 45.7 years (range: 3 months to 87.4 years). A recurrent embryonal rhabdomyosarcoma (ERMS) of the broad ligament, first diagnosed at age 23 years, harboured biallelic pathogenic somatic DICER1 variants (1 truncating and 1 RNase IIIb missense)...
June 6, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28500466/a-three-dimensional-pelvic-model-made-with-a-three-dimensional-printer-applications-for-laparoscopic-surgery-to-treat-rectal-cancer
#16
A Hamabe, M Ito
To help understand the three-dimensional (3D) spatial relationships among the highly complex structures of the pelvis, we made a novel 3D pelvic model with a 3D printing system. We created two pelvic models including the muscles, vessels, nerves, and urogenital organs; the first based on the pelvic anatomy of a healthy male volunteer and the second on the pelvic anatomy of a female volunteer with rectal cancer. The models clearly demonstrated the complicated spatial relationships between anatomical structures in the pelvis...
May 12, 2017: Techniques in Coloproctology
https://www.readbyqxmd.com/read/28497404/sexual-dysfunction-following-rectal-cancer-surgery
#17
REVIEW
V Celentano, R Cohen, J Warusavitarne, O Faiz, M Chand
INTRODUCTION: Sexual and urological problems after surgery for rectal cancer are common, multifactorial, inadequately discussed, and untreated. The urogenital function is dependent on dual autonomic sympathetic and parasympathetic innervation, and four key danger zones exist that are at risk for nerve damage during colorectal surgery: one of these sites is in the abdomen and three are in the pelvis. The aim of this study is to systematically review the epidemiology of sexual dysfunction following rectal cancer surgery, to describe the anatomical basis of autonomic nerve-preserving techniques, and to explore the scientific evidence available to support the laparoscopic or robotic approach over open surgery...
May 11, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28487750/penile-melanoma-a-20-year-analysis-of-six-patients-at-the-national-cancer-institute-of-peru-lima
#18
Andres Guevara Jabiles, Edilberto Yabar Del Mar, Gilmer Arcenio Diaz Perez, Fernando Quiroa Vera, Luis Meza Montoya, Carlos Manuel Morante Deza
Melanoma of the urogenital tract is extremely rare, accounting for less than 0.1% of melanoma cases. The global literature currently describes only 220 cases of penile melanoma, most commonly located on the glans penis. RESULTS: Penile melanoma accounts for 0.7% of penile cancers and 0.18% of melanoma cases. The average patient age for the six cases we reviewed was 44.5 years. Three of these cases (50%) involved ulceration, one case (16.7%) involved lymphovascular invasion, and three cases (50%) involved mitosis ≥ 1 mm(2) (0...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28473071/acr-appropriateness-criteria-%C3%A2-hematospermia
#19
Keyanoosh Hosseinzadeh, Aytekin Oto, Brian C Allen, Fergus V Coakley, Barak Friedman, Pat F Fulgham, Matthew S Hartman, Matthew T Heller, Christopher Porter, V Anik Sahni, Gary S Sudakoff, Sadhna Verma, Carolyn L Wang, Don C Yoo, Erick M Remer, Steven C Eberhardt
Most men with hematospermia or hemospermia (HS) are young (<40 years of age), presenting with transient or episodic HS without other signs or symptoms of disease. The condition is self-limiting in most cases and idiopathic in nature. When a cause can be identified, infections of the urogenital tract are the most common. Imaging does not play a role in this patient population. In older men (>40 years of age), clinical screening for prostate cancer is advised. Furthermore, when HS is persistent or has symptoms, causes include obstruction or stricture at the level of the verumontanum, calcifications or calculi in the prostate, ejaculatory ducts or seminal vesicles, and cysts arising within these structures...
May 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/28382905/hematospermia-a-symptom-with-many-possible-causes
#20
Michael J Mathers, Stefan Degener, Herbert Sperling, Stephan Roth
BACKGROUND: Hematospermia, or blood in the ejaculate, is a symptom with many possible causes that often gives rise to worry. Precise figures on its prevalence are unavailable. It is most common in men under 40, and its cause is usually benign; nonetheless, even a single episode of hematospermia calls for a basic diagnostic evaluation. METHODS: This review is based on pertinent articles re trieved by a search in PubMed with the key words "hemato spermia," "hemospermia," "ejaculation," "male semen," and "transrectal ultrasound...
March 17, 2017: Deutsches Ärzteblatt International
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