Shannon B Leland, Steven J Staffa, Margaret M Newhams, Robinder G Khemani, John C Marshall, Cameron C Young, Aline B Maddux, Mark W Hall, Scott L Weiss, Adam J Schwarz, Bria M Coates, Ronald C Sanders, Michele Kong, Neal J Thomas, Ryan A Nofziger, Melissa L Cullimore, Natasha B Halasa, Laura L Loftis, Natalie Z Cvijanovich, Jennifer E Schuster, Heidi Flori, Shira J Gertz, Janet R Hume, Samantha M Olson, Manish M Patel, David Zurakowski, Adrienne G Randolph
OBJECTIVES: To develop, evaluate, and explore the use of a pediatric ordinal score as a potential clinical trial outcome metric in children hospitalized with acute hypoxic respiratory failure caused by viral respiratory infections. DESIGN: We modified the World Health Organization Clinical Progression Scale for pediatric patients (CPS-Ped) and assigned CPS-Ped at admission, days 2-4, 7, and 14. We identified predictors of clinical improvement (day 14 CPS-Ped ≤ 2 or a three-point decrease) using competing risks regression and compared clinical improvement to hospital length of stay (LOS) and ventilator-free days...
August 4, 2023: Pediatric Critical Care Medicine