keyword
https://read.qxmd.com/read/38014768/hiv-disease-metrics-and-covid-19-infection-severity-and-outcomes-in-people-living-with-hiv-in-central-and-eastern-europe
#21
JOURNAL ARTICLE
Cristiana Oprea, Siobhan Quirke, Irina Ianache, Dominik Bursa, Sergii Antoniak, Nicolina Bogdanic, Anne I Vassilenko, Kersti Aimla, Raimonda Matulionyte, Nino Rukhadze, Arjan Harxhi, Lukáš Fleischhans, Botond Lakatos, Dalibor Sedlacek, Gordana Dragovic, Antonija Verhaz, Nina Yancheva, Oguzhan Acet, Konstantinos Protopapas, Justyna Dominika Kowalska
BACKGROUND: To date there remains much ambiguity in the literature regarding the immunological interplay between SARS-CoV-2 and HIV and the true risk posed to coinfected individuals. There has been little conclusive data regarding the use of CD4 cell count and HIV viral load stratification as predictors of COVID-19 severity in this cohort. METHODS: We performed a retrospective, observational cohort study on people living with HIV (PLWH) who contracted COVID-19 in central and eastern Europe...
November 28, 2023: HIV Medicine
https://read.qxmd.com/read/37948331/deep-phenotyping-of-the-lipidomic-response-in-covid-19-and-non-covid-19-sepsis
#22
JOURNAL ARTICLE
Hu Meng, Arjun Sengupta, Emanuela Ricciotti, Antonijo Mrčela, Divij Mathew, Liudmila L Mazaleuskaya, Soumita Ghosh, Thomas G Brooks, Alexandra P Turner, Alessa Soares Schanoski, Nicholas F Lahens, Ai Wen Tan, Ashley Woolfork, Greg Grant, Katalin Susztak, Andrew G Letizia, Stuart C Sealfon, E John Wherry, Krzysztof Laudanski, Aalim M Weljie, Nuala J Meyer, Garret A FitzGerald
BACKGROUND: Lipids may influence cellular penetrance by viral pathogens and the immune response that they evoke. We deeply phenotyped the lipidomic response to SARs-CoV-2 and compared that with infection with other pathogens in patients admitted with acute respiratory distress syndrome to an intensive care unit (ICU). METHODS: Mass spectrometry was used to characterise lipids and relate them to proteins, peripheral cell immunotypes and disease severity. RESULTS: Circulating phospholipases (sPLA2, cPLA2 (PLA2G4A) and PLA2G2D) were elevated on admission in all ICU groups...
November 2023: Clinical and Translational Medicine
https://read.qxmd.com/read/37870740/clinical-profile-intensive-care-needs-and-predictors-of-outcome-among-children-admitted-with-non-covid-severe-acute-respiratory-illness-sari-during-the-pandemic
#23
JOURNAL ARTICLE
Ashish Agarwal, Muralidharan Jayashree, Suresh Kumar Angurana, Raman Sharma, Arnab Ghosh, Mini P Singh, Karthi Nallasamy, Arun Bansal
OBJECTIVES: To study the epidemiology of non-coronavirus disease-2019 (non-COVID-19) respiratory viral infections with respect to their clinical profile, intensive care needs and predictors of outcome once the non-pharmacological interventions (NPI) during the coronavirus disease-2019 (COVID-19) pandemic were relaxed. METHODS: Retrospective analysis of children with Severe Acute Respiratory Illness (SARI) who were SARS-CoV-2 negative, admitted to the Pediatric Emergency/Intensive Care Unit (PICU) from July 2021 through October 2021 was conducted...
October 23, 2023: Indian Journal of Pediatrics
https://read.qxmd.com/read/37866305/short-term-predictor-for-covid-19-severity-from-a-longitudinal-multi-omics-study-for-practical-application-in-intensive-care-units
#24
JOURNAL ARTICLE
Sabine Kugler, Lisa Hahnefeld, Jan Andreas Kloka, Sebastian Ginzel, Elina Nürenberg-Goloub, Sebastian Zinn, Maria Jgt Vehreschild, Kai Zacharowski, Simone Lindau, Evelyn Ullrich, Jan Burmeister, Jörn Kohlhammer, Joachim Schwäble, Robert Gurke, Erika Dorochow, Alexandre Bennett, Stephanie Dauth, Julia Campe, Tilo Knape, Volker Laux, Aimo Kannt, Michaela Köhm, Gerd Geisslinger, Eduard Resch, Frank Behrens
BACKGROUND: The COVID-19 pandemic challenged the management of technical and human resources in intensive care units (ICU) across the world. Several long-term predictors for COVID-19 disease progression have been discovered. However, predictors to support short-term planning of resources and medication that can be translated to future pandemics are still missing. A workflow was established to identify a predictor for short-term COVID-19 disease progression in the acute phase of intensive care patients to support clinical decision-making...
October 9, 2023: Talanta
https://read.qxmd.com/read/37834947/the-predictors-of-long-covid-in-southeastern-italy
#25
JOURNAL ARTICLE
Vitaliano Nicola Quaranta, Andrea Portacci, Silvano Dragonieri, Cristian Locorotondo, Enrico Buonamico, Fabrizio Diaferia, Ilaria Iorillo, Sara Quaranta, Giovanna Elisiana Carpagnano
INTRODUCTION: Long COVID is now recognized as a common consequence of the SARS-CoV-2 infection, but we are still far from fully understanding its pathogenesis and predictive factors. Many pathophysiological factors have been studied, including ethnicity. To our knowledge, the risk factors for Long COVID have not been studied in Southeastern Italy. AIMS: The aim of this study was to evaluate the predictive factors of Long COVID in a cohort of patients from Southeastern Italy...
September 29, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/37833640/eucare-postcovid-study-a-multicentre-cohort-study-on-long-term-post-covid-19-manifestations
#26
MULTICENTER STUDY
Benedetta Varisco, Francesca Bai, Sara De Benedittis, Alessandro Tavelli, Alessandro Cozzi-Lepri, Matteo Sala, Federica Gaia Miraglia, Maria Mercedes Santoro, Francesca Ceccherini-Silberstein, Yishai Shimoni, Sivan Ravid, Tal Kozlovski, Florian König, Nico Pfeifer, Elham Shamsara, Milosz Parczewski, Antonella d'Arminio Monforte, Francesca Incardona, Chiara Mommo, Giulia Marchetti
BACKGROUND: Post-COVID-19 condition refers to persistent or new onset symptoms occurring three months after acute COVID-19, which are unrelated to alternative diagnoses. Symptoms include fatigue, breathlessness, palpitations, pain, concentration difficulties ("brain fog"), sleep disorders, and anxiety/depression. The prevalence of post-COVID-19 condition ranges widely across studies, affecting 10-20% of patients and reaching 50-60% in certain cohorts, while the associated risk factors remain poorly understood...
October 13, 2023: BMC Infectious Diseases
https://read.qxmd.com/read/37798081/seizures-in-hospitalised-paediatric-patients-with-sars-cov-2-and-comparison-of-severity-with-seizures-in-hospitalised-paediatric-patients-with-other-respiratory-viruses-during-the-covid-19-pandemic-a-population-based-cohort-study
#27
JOURNAL ARTICLE
Stavroula Anastasopoulou, Eva Svensson, Ronny Wickström, Olof Hertting, Malin Ryd Rinder, Rutger Bennet, Margareta Eriksson
OBJECTIVE: To study seizures in patients hospitalised due to SARS-CoV-2 infection, and compare their severity with seizures in patients hospitalised due to other viral respiratory tract infections (RTIs). DESIGN: Observational population-based cohort study. SETTING: Northern Stockholm. PATIENTS: Patients aged 1 month-18 years hospitalised due to SARS-CoV-2 with and without seizures, and patients of the same age hospitalised due to other viral RTIs with seizures, between 1 March 2020 and 30 June 2022...
October 5, 2023: Archives of Disease in Childhood
https://read.qxmd.com/read/37736973/the-clinical-significance-of-aspergillus-detected-in-lower-respiratory-tract-samples-of-critically-ill-covid-19-positive-patients
#28
JOURNAL ARTICLE
Heba Osman, Asra N Shaik, Paul L Nguyen, Zachary Cantor, Mirna Kaafarani, Ayman O Soubani
Objective : Critically ill patients with acute respiratory distress syndrome (ARDS) due to viral infection are at risk for secondary complications, including invasive aspergillosis. Our study aimed to characterize the clinical significance and outcome of Aspergillus species isolated from lower-respiratory-tract samples of critically ill OVID-19 patients at a single center. Design : We conducted a retrospective cohort study to evaluate the characteristics of patients with COVID-19 and aspergillus isolated from the lower respiratory tract and to identify predictors of outcomes in this population...
September 2, 2023: Advances in Respiratory Medicine
https://read.qxmd.com/read/37664680/early-3%C3%A2-day-course-of-remdesivir-for-the-prevention-of-the-progression-to-severe-covid%C3%A2-19-in-the-elderly-a-single%C3%A2-centre-real%C3%A2-life-cohort-study
#29
JOURNAL ARTICLE
Vasiliki Epameinondas Georgakopoulou, Aikaterini Gkoufa, Sotiria Makrodimitri, Dimitrios Basoulis, Aristeidis Tsakanikas, Georgios Karamanakos, Elpida Mastrogianni, Pantazis M Voutsinas, Demetrios A Spandidos, Chrysovalantis V Papageorgiou, Maria N Gamaletsou, Nikolaos V Sipsas
Remdesivir, a viral RNA polymerase inhibitor, has constituted a key component of therapeutic regimens against the pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Originally approved for administration in hospitalized patients, remdesivir leads to improved outcomes in patients with moderate to severe coronavirus disease 2019 (COVID-19). After proving to be effective in hospitalized patients, its use gained approval in early-stage disease for symptomatic outpatients who are at a high risk of progression to severe disease...
October 2023: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/37650236/long-covid-after-bamlanivimab-treatment
#30
JOURNAL ARTICLE
Teresa H Evering, Carlee B Moser, Nikolaus Jilg, Eunice Yeh, Busola Sanusi, David A Wohl, Eric S Daar, Jonathan Z Li, Paul Klekotka, Arzhang Cyrus Javan, Joseph J Eron, Judith S Currier, Michael D Hughes, Davey M Smith, Kara W Chew
BACKGROUND: Prospective evaluations of long COVID in outpatients with coronavirus disease 2019 (COVID-19) are lacking. We aimed to determine the frequency and predictors of long COVID after treatment with the monoclonal antibody bamlanivimab in ACTIV-2/A5401. METHODS: Data were analyzed from participants who received bamlanivimab 700 mg in ACTIV-2 from October 2020 to February 2021. Long COVID was defined as the presence of self-assessed COVID symptoms at week 24...
August 31, 2023: Journal of Infectious Diseases
https://read.qxmd.com/read/37614431/predictors-of-negative-outcomes-in-hospitalized-patients-with-sars%C3%A2-cov%C3%A2-2-pneumonia-a-retrospective-study
#31
JOURNAL ARTICLE
Alexandra-Maria Cristea, Dragos-Cosmin Zaharia, Daniela Jipa-Duna, Stefan Dumitrache-Rujinski, Oana Andreea Parliteanu, Alexandru Miron Bogdan, Claudia Lucia Toma
The coronavirus disease 2019 (COVID-19) pandemic posed a serious threat to human health worldwide after the first case was identified in December 2019. Specific therapeutic options for COVID-19 are lacking; thus, the treatment of patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is complex in clinical practice. Despite the development of treatment options and methods to limit the spread of SARS-CoV-2, certain patients experience critical illness and numerous deaths have occurred...
September 2023: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/37550942/sars-cov-2-vaccination-and-infection-in-ozanimod-treated-participants-with-relapsing-multiple-sclerosis
#32
JOURNAL ARTICLE
Bruce A C Cree, Rachel Maddux, Amit Bar-Or, Hans-Peter Hartung, Amandeep Kaur, Elizabeth Brown, Yicong Li, Yanhua Hu, James K Sheffield, Diego Silva, Sarah Harris
OBJECTIVE: To investigate the serologic response, predictors of response, and clinical outcomes associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination and infection in ozanimod-treated participants with relapsing multiple sclerosis (RMS) from DAYBREAK. METHODS: DAYBREAK (ClinicalTrials.gov-NCT02576717), an open-label extension study of oral ozanimod 0.92 mg, enrolled participants aged 18-55 years with RMS who completed phase 1-3 ozanimod trials...
August 7, 2023: Annals of Clinical and Translational Neurology
https://read.qxmd.com/read/37539964/the-modified-clinical-progression-scale-for-pediatric-patients-evaluation-as-a-severity-metric-and-outcome-measure-in-severe-acute-viral-respiratory-illness
#33
JOURNAL ARTICLE
Shannon B Leland, Steven J Staffa, Margaret M Newhams, Robinder G Khemani, John C Marshall, Cameron C Young, Aline B Maddux, Mark W Hall, Scott L Weiss, Adam J Schwarz, Bria M Coates, Ronald C Sanders, Michele Kong, Neal J Thomas, Ryan A Nofziger, Melissa L Cullimore, Natasha B Halasa, Laura L Loftis, Natalie Z Cvijanovich, Jennifer E Schuster, Heidi Flori, Shira J Gertz, Janet R Hume, Samantha M Olson, Manish M Patel, David Zurakowski, Adrienne G Randolph
OBJECTIVES: To develop, evaluate, and explore the use of a pediatric ordinal score as a potential clinical trial outcome metric in children hospitalized with acute hypoxic respiratory failure caused by viral respiratory infections. DESIGN: We modified the World Health Organization Clinical Progression Scale for pediatric patients (CPS-Ped) and assigned CPS-Ped at admission, days 2-4, 7, and 14. We identified predictors of clinical improvement (day 14 CPS-Ped ≤ 2 or a three-point decrease) using competing risks regression and compared clinical improvement to hospital length of stay (LOS) and ventilator-free days...
August 4, 2023: Pediatric Critical Care Medicine
https://read.qxmd.com/read/37536948/cross-sectional-study-evaluating-the-impact-of-sars-cov-2-variants-on-long-covid-outcomes-in-uk-hospital-survivors
#34
JOURNAL ARTICLE
Anita Saigal, Camila Nagoda Niklewicz, Sindhu Bhaarrati Naidu, Heba M Bintalib, Amar Jitu Shah, George Seligmann, Alan Stewart Hunter, Emmanuel Wey, Ibrahim Abubakar, Tabitha Mahungu, David Miller, Joseph Barnett, Neel Gautam Jain, Simon Brill, James Goldring, Hannah Jarvis, Colette Smith, Chibueze Ogbonnaya, John R Hurst, Marc C I Lipman, Swapna Mandal
OBJECTIVES: COVID-19 studies report on hospital admission outcomes across SARS-CoV-2 waves of infection but knowledge of the impact of SARS-CoV-2 variants on the development of Long COVID in hospital survivors is limited. We sought to investigate Long COVID outcomes, aiming to compare outcomes in adult hospitalised survivors with known variants of concern during our first and second UK COVID-19 waves, prior to widespread vaccination. DESIGN: Prospective observational cross-sectional study...
August 2023: BMJ Open Respiratory Research
https://read.qxmd.com/read/37524502/levels-and-determinants-of-overprescribing-of-antibiotics-in-the-public-and-private-primary-care-sectors-in-south-africa
#35
JOURNAL ARTICLE
Mylene Lagarde, Duane Blaauw
Although overprovision of antibiotics in primary care is a key driver of antibiotic resistance, little is known about its determinants in low-income and middle-income countries. Patient demand and financial incentives for providers are often held responsible for overprovision. Yet, inadequate provision exists in their absence and could be fuelled by quality of care issues and incorrect beliefs of providers regarding patients' expectations. We explored these issues in the private and public sector in South Africa, by conducting a cross-sectional study using standardised patients (SPs)-healthy individuals trained to portray a scripted clinical case to providers-presenting with symptoms of a viral respiratory infection in a sample of public and private sector clinics...
July 2023: BMJ Global Health
https://read.qxmd.com/read/37513774/bacterial-co-or-superinfection-in-patients-treated-in-intensive-care-unit-with-covid-19-and-influenza-associated-pneumonia
#36
JOURNAL ARTICLE
Jochen Johannes Schoettler, Stany Sandrio, Christoph Boesing, Lena Bauer, Thomas Miethke, Manfred Thiel, Joerg Krebs
Viral pneumonia is frequently complicated by bacterial co- or superinfection (c/s) with adverse effects on patients' outcomes. However, the incidence of c/s and its impact on the outcomes of patients might be dependent on the type of viral pneumonia. We performed a retrospective observational study in patients with confirmed COVID-19 pneumonia (CP) or influenza pneumonia (IP) from 01/2009 to 04/2022, investigating the incidence of c/s using a competing risk model and its impact on mortality in these patients in a tertiary referral center using multivariate logistic regressions...
July 10, 2023: Pathogens
https://read.qxmd.com/read/37457578/fatigue-presentation-severity-and-related-outcomes-in-a-prospective-cohort-following-post-covid-19-hospitalization-in-british-columbia-canada
#37
JOURNAL ARTICLE
Tianna Magel, Emily Meagher, Travis Boulter, Arianne Albert, Melody Tsai, Carola Muñoz, Chris Carlsten, James Johnston, Alyson W Wong, Aditi Shah, Chris Ryerson, Rhonda Jane Mckay, Luis Nacul
INTRODUCTION: Increasing evidence on long-term health outcomes following SARS CoV-2 infection shows post-viral symptoms can persist for months. These symptoms are often consistent with those of Myalgic Encephalomyelitis or Chronic Fatigue Syndrome (ME/CFS). The aim of the present study was to examine the prevalence and outcome predictors of post-viral fatigue and related symptoms 3- and 6-months following symptom onset. METHODS: A prospective cohort of patients hospitalized with Coronavirus disease (COVID-19) ( n  = 88) were recruited from a Post-COVID-19 Respiratory Clinic (PCRC) in Vancouver, Canada to examine predictors of long-term fatigue and substantial fatigue...
2023: Frontiers in Medicine
https://read.qxmd.com/read/37450057/assessment-of-the-correlation-between-inflammatory-status-and-severity-of-covid-19-experience-from-tertiary-hospital-in-iraq
#38
JOURNAL ARTICLE
Ali R Mulakhudair, Mariam Sabah Naser, Amal Akour, Almurtadha Mula Kh
As COVID-19 pandemic has strikingly hit the health systems of many countries, thus, the assessment of disease severity and its correlation with clinical and biochemical markers has become a necessity. These predictors can help in the diagnostics and therapeutics of COVID_19 and future viral respiratory tract infections. This was a cross-sectional study to assess the association between inflammatory makers and chronic conditions on computed tomography (CT) severity score, and D-dimer as a surrogate marker of disease severity...
July 14, 2023: Current Microbiology
https://read.qxmd.com/read/37449772/multilevel-analysis-identifying-the-factors-associated-with-rsv-detection-in-infants-admitted-for-viral-bronchiolitis-in-the-era-of-the-covid-19-pandemic
#39
JOURNAL ARTICLE
Milena Villamil-Osorio, Luisa F Moyano-Ariza, Germán Camacho-Moreno, Sonia M Restrepo-Gualteros, Monica P Sossa-Briceño, Carlos E Rodriguez-Martinez
OBJECTIVES: To identify factors independently associated with respiratory syncytial virus (RSV) detection in infants admitted for viral bronchiolitis during 3 consecutive years, before and during the COVID-19 pandemic, in Bogota, Colombia, a middle-income country with a subtropical highland climate. METHODS: An analytical cross-sectional study was conducted before and during the COVID-19 pandemic, including patients with a diagnosis of viral bronchiolitis admitted to all the hospitals of the city between January 2019 and November 2021...
July 14, 2023: Pediatric Pulmonology
https://read.qxmd.com/read/37419414/clinical-predictors-of-wheeze-trajectories-and-associations-with-allergy-in-asian-children
#40
JOURNAL ARTICLE
Hui Xing Lau, Zhaojin Chen, Hugo Van Bever, Elizabeth Huiwen Tham, Yiong Huak Chan, Qai Ven Yep, Anne Eng Neo Goh, Oon Hoe Teoh, Kok Hian Tan, Fabian Kok Peng Yap, Keith M Godfrey, Johan G Eriksson, Yap Seng Chong, Bee Wah Lee, Lynette Pei-Chi Shek, Evelyn Xiu Ling Loo
BACKGROUND: Childhood wheezing is a highly heterogeneous condition with incomplete understanding of the characteristics of wheeze trajectories, particularly for persistent wheeze. OBJECTIVE: To characterise predictors and allergic comorbidities of distinct wheeze trajectories in a multi-ethnic Asian cohort. METHODS: A total of 974 mother-child pairs from the prospective XXX cohort were included in this study. Wheeze and allergic comorbidities in the first eight years of life were assessed using the modified ISAAC questionnaires and skin prick tests...
July 5, 2023: Annals of Allergy, Asthma & Immunology
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