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https://www.readbyqxmd.com/read/27895690/rhinovirus-and-childhood-asthma-an-update
#1
REVIEW
Dae Jin Song
Asthma is recognized as a complex disease resulting from interactions between multiple genetic and environmental factors. Accumulating evidence suggests that respiratory viral infections in early life constitute a major environmental risk factor for the development of childhood asthma. Respiratory viral infections have also been recognized as the most common cause of asthma exacerbation. The advent of molecular diagnostics to detect respiratory viruses has provided new insights into the role of human rhinovirus (HRV) infections in the pathogenesis of asthma...
November 2016: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/27748303/aetiology-outcomes-predictors-of-mortality-in-acute-respiratory-distress-syndrome-from-a-tertiary-care-centre-in-north-india
#2
Surendra K Sharma, Anunay Gupta, Ashutosh Biswas, Abhishek Sharma, Atul Malhotra, K T Prasad, Sreenivas Vishnubhatla, Sajal Ajmani, Hridesh Mishra, Manish Soneja, Shobha Broor
BACKGROUND & OBJECTIVES: Acute respiratory distress syndrome (ARDS) is a common disorder in critically ill patients and is associated with high mortality. There is a paucity of literature on this condition from developing countries. This prospective observational study was designed to find out the aetiology, outcomes and predictors of mortality in ARDS. METHODS: Sixty four consecutive patients who satisfied American-European Consensus Conference (AECC) definition of ARDS from medical Intensive Care Unit (ICU) of a tertiary care centre in New Delhi, India, were enrolled in the study...
June 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/27691995/the-presence-of-fever-in-adults-with-influenza-and-other-viral-respiratory-infections
#3
A A Chughtai, Q Wang, T C Dung, C R Macintyre
We compared the rates of fever in adult subjects with laboratory-confirmed influenza and other respiratory viruses and examined the factors that predict fever in adults. Symptom data on 158 healthcare workers (HCWs) with a laboratory-confirmed respiratory virus infection were collected using standardized data collection forms from three separate studies. Overall, the rate of fever in confirmed viral respiratory infections in adult HCWs was 23·4% (37/158). Rates varied by virus: human rhinovirus (25·3%, 19/75), influenza A virus (30%, 3/10), coronavirus (28·6%, 2/7), human metapneumovirus (28·6%, 2/7), respiratory syncytial virus (14·3%, 4/28) and parainfluenza virus (8·3%, 1/12)...
January 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/27679462/sleep-habits-and-susceptibility-to-upper-respiratory-illness-the-moderating-role-of-subjective-socioeconomic-status
#4
Aric A Prather, Denise Janicki-Deverts, Nancy E Adler, Martica Hall, Sheldon Cohen
BACKGROUND: Sleep is a predictor of infectious illness that may depend on one's socioeconomic status (SES). PURPOSE: This study aimed to investigate the moderating effects of objective and subjective SES on sleep-clinical cold risk link and test whether nasal inflammation serves as a plausible biological pathway. METHODS: This study combined data (n = 732) from three viral challenge studies. Measures of self-reported sleep and objective and subjective measures of SES were obtained...
September 27, 2016: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
https://www.readbyqxmd.com/read/27608345/the-utility-of-procalcitonin-in-the-prediction-of-serious-bacterial-infection-in-a-tertiary-paediatric-intensive-care-unit
#5
S M Matha, S N Rahiman, B G Gelbart, T D Duke
To determine utility of procalcitonin (PCT) for the prediction of bacterial infection in critically ill children, we analysed the relationship between serum PCT, cultures and other laboratory markers of bacterial sepsis or viral infection in a tertiary paediatric intensive care unit (PICU). The outcome measures were levels of PCT in proven bacteraemia, pneumonia and viral respiratory infection; and comparison of PCT to immature to total neutrophil ratio (ITR) in prediction of bacteraemia. In 420 children with suspected sepsis, 1,226 serum PCT levels were analysed...
September 2016: Anaesthesia and Intensive Care
https://www.readbyqxmd.com/read/27532864/sustained-viremia-and-high-viral-load-in-respiratory-tract-secretions-are-predictors-for-death-in-immunocompetent-adults-with-adenovirus-pneumonia
#6
Li Gu, Jiuxin Qu, Bing Sun, Xiaomin Yu, Hui Li, Bin Cao
The predictors for fatal adenovirus (AdV) pneumonia among immunocompetent adults are unclear. Laboratory-confirmed, hospitalized AdV pneumonia adults were prospectively enrolled in Beijing Chao-Yang hospital from March to June 2013. Clinical data and serial whole blood and respiratory tract secretions from such patients were collected. Quantitative real-time polymerase chain reaction was performed to quantify the viral load. A total of 14 AdV pneumonia cases were consecutively enrolled, and four of them were fatal...
2016: PloS One
https://www.readbyqxmd.com/read/27439403/measurement-of-lipocalin-2-and-syndecan-4-levels-to-differentiate-bacterial-from-viral-infection-in-children-with-community-acquired-pneumonia
#7
Susanna Esposito, Sonia Bianchini, Monia Gambino, Barbara Madini, Giada Di Pietro, Giulia Umbrello, Maria Lory Presicce, Luca Ruggiero, Leonardo Terranova, Nicola Principi
BACKGROUND: In this study, we evaluated the lipocalin-2 (LIP2) and syndecan-4 (SYN4) levels in children who were hospitalized for radiologically confirmed CAP in order to differentiate bacterial from viral infection. The results regarding the LIP2 and SYN4 diagnostic outcomes were compared with the white blood cell (WBC) count and C reactive protein (CRP) levels. METHODS: A total of 110 children <14 years old who were hospitalized for radiologically confirmed CAP were enrolled...
2016: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/27221732/poor-congruence-with-guidelines-in-the-use-of-antibiotics-for-acute-bronchitis-a-descriptive-study-based-on-electronic-health-records
#8
Sara Malo, Beatriz Poblador-Plou, Alexandra Prados-Torres, María Jesús Lallana, Clara Laguna-Berna, María José Rabanaque
BACKGROUND: Although acute bronchitis is frequently viral in nature, antibiotics are usually inappropriately prescribed in Primary Care to treat this condition, with serious public health consequences. OBJECTIVE: To determine the prevalence and predictors of appropriate management of antibiotic use in acute bronchitis processes diagnosed in outpatients in the Spanish region of Aragón. METHODS: Four different electronic health databases provided demographic and clinical information pertaining to patients diagnosed with acute bronchitis in Primary Care in Aragón during 2011, as well as data for corresponding antibiotic prescriptions dispensed at pharmacies...
October 2016: Family Practice
https://www.readbyqxmd.com/read/27185552/mortality-predictors-in-recipients-developing-acute-respiratory-distress-syndrome-due-to-pneumonia-after-kidney-transplantation
#9
Pengpeng Zhang, Qifa Ye, Qiquan Wan, Jiandang Zhou
BACKGROUND: The aim of the present study was to investigate the risk factors related to hospital mortality due to infection in kidney recipients with ARDS meeting the Berlin definition. METHODS: Univariate and multivariate logistic regression analysis were used to confirm the independent risk factors related to infection-associated mortality. RESULTS: From January 2001 to August 2014, a total of 94 recipients with acute respiratory dress syndrome (ARDS) caused by pneumonia following kidney transplantation were enrolled in the present study...
August 2016: Renal Failure
https://www.readbyqxmd.com/read/27114460/heterozygous-stat1-gain-of-function-mutations-underlie-an-unexpectedly-broad-clinical-phenotype
#10
Julie Toubiana, Satoshi Okada, Julia Hiller, Matias Oleastro, Macarena Lagos Gomez, Juan Carlos Aldave Becerra, Marie Ouachée-Chardin, Fanny Fouyssac, Katta Mohan Girisha, Amos Etzioni, Joris Van Montfrans, Yildiz Camcioglu, Leigh Ann Kerns, Bernd Belohradsky, Stéphane Blanche, Aziz Bousfiha, Carlos Rodriguez-Gallego, Isabelle Meyts, Kai Kisand, Janine Reichenbach, Ellen D Renner, Sergio Rosenzweig, Bodo Grimbacher, Frank L van de Veerdonk, Claudia Traidl-Hoffmann, Capucine Picard, Laszlo Marodi, Tomohiro Morio, Masao Kobayashi, Desa Lilic, Joshua D Milner, Steven Holland, Jean-Laurent Casanova, Anne Puel
Since their discovery in patients with autosomal dominant (AD) chronic mucocutaneous candidiasis (CMC) in 2011, heterozygous STAT1 gain-of-function (GOF) mutations have increasingly been identified worldwide. The clinical spectrum associated with them needed to be delineated. We enrolled 274 patients from 167 kindreds originating from 40 countries from 5 continents. Demographic data, clinical features, immunological parameters, treatment, and outcome were recorded. The median age of the 274 patients was 22 years (range, 1-71 years); 98% of them had CMC, with a median age at onset of 1 year (range, 0-24 years)...
June 23, 2016: Blood
https://www.readbyqxmd.com/read/26980847/compliance-with-the-use-of-medical-and-cloth-masks-among-healthcare-workers-in-vietnam
#11
Abrar Ahmad Chughtai, Holly Seale, Tham Chi Dung, Andrew Hayen, Bayzidur Rahman, C Raina MacIntyre
BACKGROUND: Masks are often worn in healthcare settings to prevent the spread of infection from healthcare workers (HCWs) to patients. Masks are also used to protect the employee from patient-generated infectious organisms but poor compliance can reduce efficacy. The aim of this study was to examine the factors influencing compliance with the use of medical and cloth masks amongst hospital HCWs. METHODS: HCWs compliance with the use of medical and cloth masks was measured over a 4-week period in a randomized controlled trial in Vietnam...
June 2016: Annals of Occupational Hygiene
https://www.readbyqxmd.com/read/26947937/hospital-assisted-home-care-after-early-discharge-from-a-swedish-neonatal-intensive-care-unit-was-safe-and-readmissions-were-rare
#12
Björn Lundberg, Carl Lindgren, Charlotte Palme-Kilander, Annica Örtenstrand, Anna-Karin Edstedt Bonamy, Ihsan Sarman
AIM: It is common in Sweden to discharge infants early from a neonatal intensive care unit (NICU) and provide hospital-assisted neonatal home care (HANHC), as an alternative to hospital care, for infants with a persisting need for specialised care. This study assessed the safety of HANHC by reviewing hospital readmissions. METHODS: We retrospectively reviewed the files of all 1410 infants enrolled in HANHC at the NICU at Sachs' Children's Hospital, Stockholm, from 2002 to 2011 up until hospital readmission or their discharge from HANHC...
August 2016: Acta Paediatrica
https://www.readbyqxmd.com/read/26916343/prevalence-codetection-and-seasonal-distribution-of-upper-airway-viruses-and-bacteria-in-children-with-acute-respiratory-illnesses-with-cough-as-a-symptom
#13
K F O'Grady, K Grimwood, T P Sloots, D M Whiley, J P Acworth, N Phillips, V Goyal, A B Chang
Most studies exploring the role of upper airway viruses and bacteria in paediatric acute respiratory infections (ARI) focus on specific clinical diagnoses and/or do not account for virus-bacteria interactions. We aimed to describe the frequency and predictors of virus and bacteria codetection in children with ARI and cough, irrespective of clinical diagnosis. Bilateral nasal swabs, demographic, clinical and risk factor data were collected at enrollment in children aged <15 years presenting to an emergency department with an ARI and where cough was a symptom...
June 2016: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/26908489/rhinovirus-disease-in-children-seeking-care-in-a-tertiary-pediatric-emergency-department
#14
Helen Y Chu, Janet A Englund, Bonnie Strelitz, Kirsten Lacombe, Charla Jones, Kristin Follmer, Emily K Martin, Miranda Bradford, Xuan Qin, Jane Kuypers, Eileen J Klein
BACKGROUND: Rhinovirus is the most common cause of viral respiratory tract infections in children. Virologic predictors of lower respiratory tract infection (LRTI), such as viral load and the presence of another respiratory virus (coinfection), are not well characterized in pediatric outpatients. METHODS: Mid-nasal turbinate samples were collected from children presenting for care to the Seattle Children's Hospital emergency department (ED) or urgent care with a symptomatic respiratory infection between December 2011 and May 2013...
March 2016: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/26858436/respiratory-virus-transmission-dynamics-determine-timing-of-asthma-exacerbation-peaks-evidence-from-a-population-level-model
#15
Rosalind M Eggo, James G Scott, Alison P Galvani, Lauren Ancel Meyers
Asthma exacerbations exhibit a consistent annual pattern, closely mirroring the school calendar. Although respiratory viruses--the "common cold" viruses--are implicated as a principal cause, there is little evidence to link viral prevalence to seasonal differences in risk. We jointly fit a common cold transmission model and a model of biological and environmental exacerbation triggers to estimate effects on hospitalization risk. Asthma hospitalization rate, influenza prevalence, and air quality measures are available, but common cold circulation is not; therefore, we generate estimates of viral prevalence using a transmission model...
February 23, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/26805870/association-between-psychological-flexibility-and-health-beliefs-in-the-uptake-of-influenza-vaccination-among-people-with-chronic-respiratory-diseases-in-hong-kong
#16
Kin Wai Cheung, Yim Wah Mak
It is common for elderly people and those with such chronic disorders as respiratory diseases to suffer severe complications from influenza, a viral infection. The voluntary uptake of vaccination is vital to the effectiveness of influenza prevention efforts. The Health Belief Model (HBM) is the most commonly used framework in the field of vaccination behavior to explain the decision that people make to accept or refuse vaccination. In addition, psychological flexibility is considered helpful in causing people to be open to adopting new practices that are consistent with their values...
February 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/26782568/ormdl3-variants-associated-with-bronchiolitis-susceptibility-in-a-chinese-population
#17
X T Liu, L Ren, L L Zhou, Q Y Xiao, Y Deng, E M Liu
Recent studies revealed common genetic risks for both viral bronchiolitis and asthma. Genome-wide association studies revealed that rs7216389 in the ORMDL3 gene is associated with childhood asthma. We conducted a case-control study examining the associations between ORMDL3 polymorphisms (rs7216389, rs12603332, and rs11650680) and bronchiolitis susceptibility/viral findings among 247 infant bronchiolitis cases and 190 healthy controls. We genotyped single nucleotide polymorphisms by matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry and detected respiratory viruses with multiplex reverse transcriptase-polymerase chain reaction...
December 29, 2015: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/26699199/incidence-and-predictors-of-respiratory-viral-infections-by-multiplex-pcr-in-allogeneic-hematopoietic-cell-transplant-recipients-50-years-and-older-including-geriatric-assessment
#18
Christopher R D'Angelo, Masha Kocherginsky, Jennifer Pisano, Michael R Bishop, Lucy A Godley, Justin Kline, Richard A Larson, Hongtao Liu, Olutoyosi Odenike, Wendy Stock, Andrew S Artz
Community respiratory viruses (CRV) are important agents of morbidity and mortality within the allogeneic hematopoietic stem cell transplant (HCT) population. Few proven methods to prevent CRV infections exist. No studies have specifically investigated their impact on older patients. We reviewed patients 50 years and older undergoing HCT between 2009-2013 to determine the incidence of CRV infection using multiplex PCR and risk factors for infection including geriatric assessment (GA). Thirty-two first episode CRV infections occurred in 118 patients for a 1-year cumulative incidence of 27...
August 2016: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/26683973/epidemiology-co-infections-and-outcomes-of-viral-pneumonia-in-adults-an-observational-cohort-study
#19
Matthew P Crotty, Shelby Meyers, Nicholas Hampton, Stephanie Bledsoe, David J Ritchie, Richard S Buller, Gregory A Storch, Scott T Micek, Marin H Kollef
Advanced technologies using polymerase-chain reaction have allowed for increased recognition of viral respiratory infections including pneumonia. Co-infections have been described for several respiratory viruses, especially with influenza. Outcomes of viral pneumonia, including cases with co-infections, have not been well described. This was observational cohort study conducted to describe hospitalized patients with viral pneumonia including co-infections, clinical outcomes, and predictors of mortality. Patients admitted from March 2013 to November 2014 with a positive respiratory virus panel (RVP) and radiographic findings of pneumonia within 48  h of the index RVP were included...
December 2015: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26574720/pathogenesis-and-prevention-strategies-of-severe-asthma-exacerbations-in-children
#20
REVIEW
James Cook, Sejal Saglani
PURPOSE OF REVIEW: Exacerbations of asthma in children are most frequently precipitated by respiratory infections with a seasonal pattern. However, management takes little account of the underlying infective or other precipitant abnormality. RECENT FINDINGS: Interactions between environmental triggers, the airway microbiome and innate immune responses are key determinants of exacerbations. Elevated innate cytokines interleukin (IL)-33 and IL-25, and abnormal molecular responses in the interferon pathway are associated with rhinoviral infections...
January 2016: Current Opinion in Pulmonary Medicine
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