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https://www.readbyqxmd.com/read/29786098/syntheses-structures-and-magnetic-properties-of-three-new-mn-ii-mo-iii-cn-7-4-molecular-magnets
#1
Xiao-Qin Wei, Qian Pi, Fu-Xing Shen, Dong Shao, Hai-Yan Wei, Xin-Yi Wang
By reaction of K4[MoIII(CN)7]·2H2O, Mn(ClO4)2·6H2O and bidentate chelating ligands, three new cyano-bridged compounds, namely Mn2(3-pypz)(H2O)(CH3CN)[Mo(CN)7] (1), Mn2(1-pypz)(H2O)(CH3CN)[Mo(CN)7] (2) and Mn2(pyim)(H2O)(CH3CN)[Mo(CN)7] (3) (3-pypz = 2-(1H-pyrazol-3-yl)pyridine, 1-pypz = 2-(1H-pyrazol-1-yl)pyridine, pyim = 2-(1H-imidazol-2-yl)pyridine), have been synthesized and characterized structurally and magnetically. Single crystal X-ray analyses revealed that although the chelating ligands are different, compounds 1 to 3 are isomorphous and crystallize in the same monoclinic space group C2/m...
May 22, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29749126/in-situ-synthesis-of-mop-nanoflakes-intercalated-n-doped-graphene-nanobelts-from-moo-3-amine-hybrid-for-high-efficient-hydrogen-evolution-reaction
#2
Chao Huang, Chaoran Pi, Xuming Zhang, Kang Ding, Ping Qin, Jijiang Fu, Xiang Peng, Biao Gao, Paul K Chu, Kaifu Huo
Molybdenum phosphide (MoP) is a promising non-noble-metal electrocatalyst in the hydrogen evolution reaction (HER), but practical implementation is impeded by the sluggish HER kinetics and poor chemical stability. Herein, a novel high-efficiency HER electrocatalyst comprising MoP nanoflakes intercalated nitrogen-doped graphene nanobelts (MoP/NG), which are synthesized by one-step thermal phosphiding organic-inorganic hybrid dodecylamine (DDA) inserted MoO3 nanobelts, is reported. The intercalated DDA molecules are in situ carbonized into the NG layer and the sandwiched MoO3 layer is converted into MoP nanoflakes which are intercalated between the NG layers forming the alternatingly stacked MoP/NG hybrid nanobelts...
May 10, 2018: Small
https://www.readbyqxmd.com/read/29736250/mikc-c-type-mads-box-genes-in-rosa-chinensis-the-remarkable-expansion-of-abcde-model-genes-and-their-roles-in-floral-organogenesis
#3
Jinyi Liu, Xiaodong Fu, Yuwei Dong, Jun Lu, Min Ren, Ningning Zhou, Changquan Wang
MIKCC -type MADS-box (MIKCC ) genes encode transcription factors that have crucial roles in controlling floral organogenesis and flowering time in plants. Although this gene family has been well characterized in many plant species, its evolutionary and comprehensive functional analysis in rose is lacking. In this study, 58 non-redundant MIKCC uni-transcripts were extensively identified from rose transcriptomes. Phylogenetic analysis placed these genes into 12 clades with their Arabidopsis and strawberry counterparts, and revealed that ABCDE model (including AP1/FUL, AP3/PI, AG, and SEP clades), and SOC1 and AGL6 clade genes have remarkably expanded in Rosa chinensis , whereas genes from the FLC and AGL17 clades were undetectable...
2018: Horticulture Research
https://www.readbyqxmd.com/read/29719781/a-novel-quantified-bitterness-evaluation-model-for-traditional-chinese-herbs-based-on-an-animal-ethology-principle
#4
Xue Han, Hong Jiang, Li Han, Xi Xiong, Yanan He, Chaomei Fu, Runchun Xu, Dingkun Zhang, Junzhi Lin, Ming Yang
Traditional Chinese herbs (TCH) are currently gaining attention in disease prevention and health care plans. However, their general bitter taste hinders their use. Despite the development of a variety of taste evaluation methods, it is still a major challenge to establish a quantitative detection technique that is objective, authentic and sensitive. Based on the two-bottle preference test (TBP), we proposed a novel quantitative strategy using a standardized animal test and a unified quantitative benchmark. To reduce the difference of results, the methodology of TBP was optimized...
March 2018: Acta Pharmaceutica Sinica. B
https://www.readbyqxmd.com/read/29717030/lack-of-association-between-mir-218-rs11134527-a-g-and-kawasaki-disease-susceptibility
#5
Lei Pi, Lanyan Fu, Yufen Xu, Di Che, Qiulian Deng, Xijing Huang, Meiai Li, Li Zhang, Ping Huang, Xiaoqiong Gu
Abstract Kawasaki disease (KD) is a type of disease that includes the development of a fever that lasts at least five days and involves the clinical manifestation of multicellular vasculitis. KD has become one of the most common pediatric cardiovascular diseases. Previous studies have reported that miR-218 rs11134527 A>G is associated with susceptibility to various cancer risks. However, there is a lack of evidence regarding the relationship between this polymorphism and KD risk. This study explored the correlation between the miR-218 rs11134527 A>G polymorphism and the risk of KD...
May 1, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29715459/mesenchymal-stem-cells-drive-paclitaxel-resistance-in-erbb2-erbb3-coexpressing-breast-cancer-cells-via-paracrine-of-neuregulin-1
#6
Jin Chen, Qun Ren, Yuanming Cai, Tingting Lin, Weimin Zuo, Jin Wang, Rong Lin, Ling Zhu, Ping Wang, Huiyue Dong, Hu Zhao, Lianghu Huang, Yunfeng Fu, Shunliang Yang, Jianming Tan, Xiaopeng Lan, Shuiliang Wang
We had previously demonstrated that increased expression of ErbB3 is required for ErbB2-mediated paclitaxel resistance in breast cancer cells. In the present study, we have explored the possible role of mesenchymal stem cells (MSCs) in regulating the paclitaxel-sensitivity of ErbB2/ErbB3-coexpressing breast cancer cells. We show that human umbilical cord-derived MSCs express significantly higher level of neuregulin-1 as compared with ErbB2/ErbB3-coexpressing breast cancer cells themselves. Coculture or treatment with conditioned medium of MSCs not only decreases the anti-proliferation effect of paclitaxel on ErbB2/ErbB3-coexpressing breast cancer cells, but also significantly inhibits paclitaxel-induced apoptosis...
April 28, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29708961/cellular-mechanisms-of-hepatoprotection-mediated-by-m2-like-macrophages
#7
Li Bai, Liming Fu, Lu Li, Feng Ren, Qingfen Zheng, Shuang Liu, Yuanping Han, Sujun Zheng, Yu Chen, Zhongping Duan
BACKGROUND Acute liver injury in the setting of hepatic fibrosis is an intriguing and still unsettled issue. We previously have demonstrated the protective effects conferred by M2-like macrophages in the fibrotic liver. In the present work, we further decipher the cellular mechanisms governing this hepatoprotection. MATERIAL AND METHODS Macrophages were isolated from control mice (M0 macrophages), then polarized into M1 or M2 phenotype using IFN-γ or IL-4, respectively. Conditioned media (CM) from M0, M1, and M2 macrophages were harvested and applied to M1 macrophages...
April 30, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29693629/a-proteomic-view-of-salmonella-typhimurium-in-response-to-phosphate-limitation
#8
Jiezhang Jiang, Kaiwen Yu, Linlu Qi, Yanhua Liu, Sen Cheng, Mei Wu, Zhen Wang, Jiaqi Fu, Xiaoyun Liu
Salmonella enterica serovar Typhimurium ( S. Typhimurium), an important foodborne pathogen, often encounters phosphate (Pi ) shortage both in the environment and inside host cells. To gain a global view on its physiological responses to Pi starvation, we performed proteomic profiling of S. Typhimurium upon the shift from Pi -rich to Pi -low conditions. In addition to the Pho regulon, many metabolic processes were up-regulated, such as glycolysis, pentose phosphate pathway, pyrimidine degradation, glycogen, and trehalose metabolism, allowing us to chart an overview of S...
April 25, 2018: Proteomes
https://www.readbyqxmd.com/read/29679136/the-pedicle-instrumentation-and-percutaneous-elevation-pi-pe-a-new-cementless-surgical-technique-in-type-a-post-traumatic-vertebral-fractures
#9
Andrea Piazzolla, Giuseppe Solarino, Davide Bizzoca, Claudia Parato, Gaetano Monteleone, Franca Dicuonzo, Biagio Moretti
PURPOSE: To investigate if bone substitutes are strictly necessary to restore the vertebral body height and improve the clinical outcome, in patients with thoracolumbar or lumbar AO type A post-traumatic vertebral fractures, managed with balloon kyphoplasty combined with posterior screw and rod system. METHODS: 105 patients with post-traumatic thoracolumbar spine fracture were recruited. At baseline, the patients underwent a CT and an MRI of the spine. Clinical evaluation was performed, using the Visual Analog Scale (VAS) and the Oswestry Disability Index (ODI), at baseline, 48 h after surgery, at 3-month follow-up (FU), 6-month FU, 48 h after the instrumentation removal and at 24-month FU...
April 20, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29664291/exploration-of-biaryl-carboxylic-acids-as-proton-shuttles-for-the-selective-functionalization-of-indole-c-h-bonds
#10
Jing-Jing Pi, Xiao-Yu Lu, Jing-Hui Liu, Xi Lu, Bin Xiao, Yao Fu, Nicolas Guimond
A survey of diversely substituted 2-arylbenzoic acid were synthesized and tested for use as proton shuttle in the direct arylation of indoles with bromobenzenes. It was found that 3-ethoxy-2-phenylbenzoic acid gives superior yield and selectivity for this class of substrates.
April 17, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29600170/is-marcus-gunn-jaw-winking-a-primitive-reflex-rat-neuroanatomy
#11
Hou-Cheng Liang, Jing-Dong Zhang, Pi-Fu Luo, Ying Qiao, An-Le Su, Ting Zhang, Hong-Na Zhu
AIM: To investigate a possible trigeminal proprioceptive-oculomotor neural pathway and explore possible synaptic connections between neurons in this pathway. Attempt to bring a new insight to mechanism of Marcus Gunn syndrome (MGS). METHODS: Anterograde and retrograde tract tracing was applied and combined with immunofluorescent stain in rats. After electrophysiological identifying mesencephalic trigeminal nucleus (Vme) neurons, intracellular injection of tracer was performed to trace axon trajectory...
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29589089/tetraspanin-enriched-microdomains-regulate-digitation-junctions
#12
Chao Huang, Chenying Fu, Jonathan D Wren, Xuejun Wang, Feng Zhang, Yanhui H Zhang, Samuel A Connel, Taosheng Chen, Xin A Zhang
Tetraspanins co-emerged with multi-cellular organisms during evolution are typically localized at the cell-cell interface, and form tetraspanin-enriched microdomains (TEMs) by associating with each other and other membrane molecules. Tetraspanins affect various biological functions, but how tetraspanins engage in multi-faceted functions at the cellular level is largely unknown. When cells interact, the membrane microextrusions at the cell-cell interfaces form dynamic, digit-like structures between cells, which we term digitation junctions (DJs)...
March 27, 2018: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/29588601/midazolam-activates-caspase-mapks-and-endoplasmic-reticulum-stress-pathways-and-inhibits-cell-cycle-and-akt-pathway-to-induce-apoptosis-in-tm3-mouse-leydig-progenitor-cells
#13
Fu-Chi Kang, Shu-Chun Wang, Ming-Min Chang, Bo-Syong Pan, Kar-Lok Wong, Ka-Shun Cheng, Edmund Cheung So, Bu-Miin Huang
Background: Midazolam (MDZ) has powerful hypnosis, amnesia, anti-anxiety and anticonvulsant effects. Studies have shown that prenatally developmental toxicity of diazepam can be observed in many organs/tissues. However, it remains elusive in male reproductive system. Materials and methods: TM3 mouse Leydig progenitor cell line was used to determine whether MDZ has any unfavorable effects. Results: Midazolam significantly decreased cell viability in dose- and time-dependent manners in TM3 cells...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29587394/synthesis-and-evaluation-of-the-anticonvulsant-activities-of-4-2-alkylthio-benzo-d-oxazol-5-yl-2-4-dihydro-3h-1-2-4-triazol-3-ones
#14
Ming-Xia Song, Zhen-Yuan Wang, Shi-Hui He, Sheng-Wang Yu, Shi-Long Chen, Dong-Fu Guo, Wen-Hao Zhao, Xian-Qing Deng
In this study, a novel series of 4-(2-(alkylthio)benzo[ d ]oxazol-5-yl)-2,4-dihydro-3 H -1,2,4-triazol-3-ones ( 4a - m ) was designed and synthesized. The anticonvulsant activities of these compounds were evaluated by using the maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole (scPTZ) seizure models in mice. The neurotoxicity of these compounds was evaluated using the rotarod neurotoxicity test. The majority of compounds showed anti-MES activities at 100 or 300 mg/kg. Compound 4g was considered to be the most promising, based on its potency against MES- and PTZ-induced seizures with ED50 values of 23...
March 25, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29581781/lass2-regulates-invasion-and-chemoresistance-via-erk-drp1-modulated-mitochondrial-dynamics-in-bladder-cancer-cells
#15
Lijuan Huang, Ting Luan, Yujin Chen, Xin Bao, Yinglong Huang, Shi Fu, Haifeng Wang, Jiansong Wang
Mitochondria coordinated a lot of vital cellular processes of energy production and distribution. Change of mitochondrial functions has been implicated in cancer progression. The present study aims to investigate the involvement of mitochondria dynamics in LASS2 induced invasion and chemoresistance of bladder cancer cells. J82 and BIU87 cell lines were used for LASS2 plasmid transfection while siRNA knockdown was carried out in 5637 cell line. Matrigel invasion assay and Annexin V/PI staining demonstrated that LASS2 negatively regulated cancer cell invasion and chemoresistance...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29578485/cysteine-rich-repeat-domains-2-and-4-are-amyloid-%C3%AE-binding-domains-of-neurotrophin-receptor-p75ntr-and-potential-targets-to-block-amyloid-%C3%AE-neurotoxicity
#16
Ye-Ran Wang, Jun Wang, Yu-Hui Liu, Gong-Ling Hu, Chang-Yue Gao, Yan-Jiang Wang, Xin-Fu Zhou, Fan Zeng
The p75 neurotrophin receptor (p75NTR) is an amyloid-β (Aβ) receptor that both mediates Aβ neurotoxicity and regulates Aβ production and deposition, thus playing an important role in the pathogenesis of Alzheimer's disease (AD). The extracellular domain of p75NTR (p75ECD), consisting of four cysteine-rich repeat domains (CRDs), was recently reported to be an endogenous anti-Aβ scavenger to block p75NTR-mediated neuronal death and neurite degeneration signaling of Aβ and pro-neurotrophins. Identification of the specific Aβ binding domains of p75NTR is crucial for illuminating their interactions and the etiology of AD...
March 23, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29573568/targeting-lmw-ptp-to-sensitize-melanoma-cancer-cells-toward-chemo-and-radiotherapy
#17
Giulia Lori, Paolo Paoli, Anna Caselli, Paolo Cirri, Riccardo Marzocchini, Monica Mangoni, Cinzia Talamonti, Lorenzo Livi, Giovanni Raugei
Tumor resistance to apoptosis is one the main causes of anticancer treatment failure. Previous studies showed that LMW-PTP overexpression enhances resistance of cancer cells to traditional anticancer drugs. Today, the role of LMW-PTP in inducing resistance to apoptosis in melanoma cells remains to be elucidated. Experimental setting include MTT assay, Annexin V/Pi method, and colony assay to assess whether silencing of LMW-PTP improves the sensitivity of A375 to dacarbazine, 5-FU, and radiotherapy. Pharmacological targeting of LMW-PTP was obtained using Morin, a LMW-PTP inhibitor...
March 24, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29571711/curcumin-plays-neuroprotective-roles-against-traumatic-brain-injury-partly-via-nrf2-signaling
#18
Wenwen Dong, Bei Yang, Linlin Wang, Bingxuan Li, Xiangshen Guo, Miao Zhang, Zhenfei Jiang, Jingqi Fu, Jingbo Pi, Dawei Guan, Rui Zhao
Traumatic brain injury (TBI), which leads to high mortality and morbidity, is a prominent public health problem worldwide with no effective treatment. Curcumin has been shown to be beneficial for neuroprotection in vivo and in vitro, but the underlying mechanism remains unclear. This study determined whether the neuroprotective role of curcumin in mouse TBI is dependent on the NF-E2-related factor (Nrf2) pathway. The Feeney weight-drop contusion model was used to mimic TBI. Curcumin was administered intraperitoneally 15 min after TBI induction, and brains were collected at 24 h after TBI...
March 20, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29552860/-protective-effects-of-total-saponins-of-panax-japonicas-on-hepg2-cell-apoptosis-induced-with-palmitic-acid
#19
Hao Tu, Qin Zhou, Xun Zhang, Ting Wang, Cheng-Fu Yuan, Chang-Cheng Zhang, Ding Yuan, Zhao-Qi Liu
This study aimed to investigate the molecular mechanism and protective effect of total saponins of Panax japonicas (TSPJ) on HepG2 cells apoptosis induced by palmitic acid (PA).The HepG2 cells were cultured in vitro , and divided into five groups: the control group, the model group, the high-dose group (50 mg·L⁻¹), the middle-dose group (25 mg·L⁻¹) and the low-dose group (12.5 mg·L⁻¹).The cells of the five groups were cultured continuously for 24 hours. The cell viability was measured with MTT. HepG2 cells apoptosis was detected by Hoechest staining and Annexin V-FITC/PI staining...
January 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29543785/long-noncoding-rna-taurine-upregulated-gene1-tug1-promotes-tumor-growth-and-metastasis-through-tug1-mir-129-5p-astrocyte-elevated-gene-1-aeg-1-axis-in-malignant-melanoma
#20
Jianwen Long, Qiqige Menggen, Qimige Wuren, Quan Shi, Xianming Pi
BACKGROUND Malignant melanoma is a class of malignant tumors derived from melanocytes. lncRNAs have been considered as pro-/anti-tumor factors in progression of cancers. The function of lncRNA TUG1 on growth of melanoma was investigated in this study. MATERIAL AND METHODS The TUG1 and miR-129-5p expression were examined via qRT-PCR. The protein expression was investigated by Western blotting assay. Luciferase reporter assay was used to assess if lncRNA TUG1 can bind to miR-129-5p and if miR-129-5p can target AEG1 mRNA...
March 15, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
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