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https://www.readbyqxmd.com/read/27913881/phase-ii-trial-of-s-1-plus-leucovorin-in-patients-with-advanced-gastric-cancer-and-clinical-prediction-by-s-1-pharmacogenetic-pathway
#1
Ming-Ming He, Dong-Sheng Zhang, Feng Wang, Zi-Xian Wang, Shu-Qiang Yuan, Zhi-Qiang Wang, Hui-Yan Luo, Chao Ren, Miao-Zhen Qiu, Ying Jin, De-Shen Wang, Dong-Liang Chen, Zhao-Lei Zeng, Yu-Hong Li, Yang-Yang He, Yuan-Tao Hao, Pi Guo, Feng-Hua Wang, Yi-Xin Zeng, Rui-Hua Xu
BACKGROUND: The first one-arm phase II trial aimed to evaluate and predict efficacy and safety of S-1 plus oral leucovorin (S-1/LV) as first-line chemotherapy for patients with advanced gastric cancer (AGC), using S-1 pharmacogenetic pathway approach. PATIENTS AND METHODS: A total of 39 patients orally took S-1 at conventional dose and LV simultaneously at a dose of 25 mg twice daily for a week, within a 2-week cycle. The primary endpoint was overall response rate (ORR), while the secondary endpoints were progression-free survival (PFS), time to failure (TTF), overall survival (OS), disease control rate (DCR), and adverse events (AEs)...
December 2, 2016: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/27899152/the-anti-staphylococcus-aureus-activity-of-the-phenanthrene-fraction-from-fibrous-roots-of-bletilla-striata
#2
Jing-Jing Guo, Bin-Ling Dai, Ni-Pi Chen, Li-Xia Jin, Fu-Sheng Jiang, Zhi-Shan Ding, Chao-Dong Qian
BACKGROUND: Bletillae Rhizoma, the tuber of Bletilla striata, has been used in Chinese traditional medicine to treat infectious diseases. Chemical studies indicated that phenanthrene was one of the most important components of the herb, with a broad spectrum of antibiotic activity against Gram-positive bacteria. The objective of this study was to further characterize the antibacterial activity of the phenanthrene fraction from the fibrous root of the pseudobulb of B. striata. METHODS: The phenanthrene fraction (EF60) from the ethanol extract of fibrous roots of Bletilla striata pseudobulbs was isolated using polyamide column chromatography...
November 29, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27878398/hsp90-is-a-promising-target-in-gemcitabine-and-5-fluorouracil-resistant-pancreatic-cancer
#3
Tarik Ghadban, Judith L Dibbern, Matthias Reeh, Jameel T Miro, Tung Y Tsui, Ulrich Wellner, Jakob R Izbicki, Cenap Güngör, Yogesh K Vashist
Chemotherapy (CT) options in pancreatic cancer (PC) are limited to gemcitabine and 5-fluorouracil (5-FU). Several identified molecular targets in PC represent client proteins of HSP90. HSP90 is a promising target since it interferes with many oncogenic signaling pathways simultaneously. The aim of this study was to evaluate the efficacy of different HSP90 inhibitors in gemcitabine and 5-FU resistant PC. PC cell lines 5061, 5072 and 5156 were isolated and brought in to culture from patients being operated at our institution...
November 22, 2016: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/27874123/bacteria-derived-fluorescent-carbon-dots-for-microbial-live-dead-differentiation
#4
Xian-Wu Hua, Yan-Wen Bao, Hong-Yin Wang, Zhan Chen, Fu-Gen Wu
Microbial viability assessment plays a key role in many areas such as pathogen detection, infectious disease treatment and antimicrobial drug development. Many conventional viability dyes (such as propidium iodide, PI) used for differentiating live/dead microbes suffer from notable cytotoxicity, poor photostability and are of high cost. Thus their applications for accurate microbial viability determination are limited. Herein, for the first time we report the successful synthesis of fluorescent carbon dots (CDs) from bacteria via one-step hydrothermal carbonization...
November 22, 2016: Nanoscale
https://www.readbyqxmd.com/read/27843533/an-acetamide-derivative-as-a-camptothecin-sensitizer-for-human-non-small-cell-lung-cancer-cells-through-increased-oxidative-stress-and-jnk-activation
#5
Han-Lin Chou, Yao Fong, Hsin-Hsien Lin, Eing Mei Tsai, Jeff Yi-Fu Chen, Wen-Tsan Chang, Chang-Yi Wu, Hui-Min David Wang, Hurng-Wern Huang, Chien-Chih Chiu
In recent years, combination chemotherapy is a primary strategy for treating lung cancer; however, the issues of antagonism and side effects still limit its applications. The development of chemosensitizer aims to sensitize chemoresistant cancer cells to anticancer drugs and therefore improve the efficacy of chemotherapy. In this study, we examined whether N-[2-(morpholin-4-yl)phenyl]-2-{8-oxatricyclo[7.4.0.0,2,7]trideca-1(9),2(7),3,5,10,12-hexaen-4-yloxy}acetamide (NPOA), an acetamide derivative, sensitizes human non-small-cell lung cancer (NSCLC) H1299 cells towards camptothecin- (CPT-) induced apoptosis effects...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27822287/traditional-chinese-medicine-use-among-patients-with-psoriasis-in-taiwan-a-nationwide-population-based-study
#6
Shu-Wen Weng, Bor-Chyuan Chen, Yu-Chiao Wang, Chun-Kai Liu, Mao-Feng Sun, Ching-Mao Chang, Jaung-Geng Lin, Hung-Rong Yen
Traditional Chinese medicine (TCM) has long been used for patients with psoriasis. This study aimed to investigate TCM usage in patients with psoriasis. We analyzed a cohort of one million individuals representing the 23 million enrollees randomly selected from the National Health Insurance Research Database in Taiwan. We identified 28,510 patients newly diagnosed with psoriasis between 2000 and 2010. Among them, 20,084 (70.4%) patients were TCM users. Patients who were female, younger, white-collar workers and lived in urbanized area tended to be TCM users...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27815936/microrna-124-enhances-response-to-radiotherapy-in-human-epidermal-growth-factor-receptor-2-positive-breast-cancer-cells-by-targeting-signal-transducer-and-activator-of-transcription-3
#7
Ying Fu, Jianping Xiong
AIM: To determine whether microRNA (miR)-124 enhances the response to radiotherapy in human epidermal growth factor receptor 2 (HER2)-positive breast cancer cells by targeting signal transducer and activator of transcription 3 (Stat3). METHODS: miR-29b expression was measured in 80 pairs of breast tumor samples and adjacent normal tissues collected between January 2013 and July 2014. Activity changes of 50 canonical signaling pathways upon miR-124 overexpression were determined using Cignal Signal Transduction Reporter Array...
October 31, 2016: Croatian Medical Journal
https://www.readbyqxmd.com/read/27781257/-role-and-mechanism-research-on-reversal-of-5-fluorouracil-resistance-by-epigallocatechin-gallate-in-gastric-cancer-drug-resistance-cells-lines-sgc-7901-5-fu
#8
Hongsheng Tang, Xiangliang Zhang, Shuzhong Cui, Jin Wang, Qiang Ruan, Yonghong Huang, Dinghua Yang
: To study the role and molecular mechanism of epigallocatechin gallate (EGCG) in reversing drug-resistance to 5-fluorouracil (5-FU) in gastric cancer drug-resistant cell line SGC-7901/5-FU. METHODS: Drug-resistance gastric cancer cell line (SGC-7901/5-FU) was established by high doses of repeated impact joint drug concentration increment methods. The cell viability of the parent cell line and the drug-resistance cell line were determined by standard MTT assay. Cell survival rate of drug-resistance was calculated by the formula [(A490 of the treatment group / A490 of the control group) × 100%]...
October 25, 2016: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/27765352/dioscin-suppresses-hepatocellular-carcinoma-tumor-growth-by-inducing-apoptosis-and-regulation-of-tp53-bax-bcl2-and-cleaved-casp3
#9
Guangxian Zhang, Xiancheng Zeng, Ren Zhang, Juan Liu, Weici Zhang, Yujun Zhao, Xiaoyuan Zhang, Zhixue Wu, Yuhui Tan, Yingya Wu, Biaoyan Du
BACKGROUND: Hepatocellular carcinoma (HCC) is the most commonly diagnosed malignancy of the liver, occurs frequently in the setting of chronic liver injury. Although multiple therapeutic approaches are available, the prognosis of patients with HCC remains poor. Dioscin is a natural steroid saponin that presents in various plants. The anti-cancer and anti-fibrotic effects have been extensively reported. However, the effect of dioscin on HCC remains unclear. We aimed to investigate the anti-HCC properties of dioscin in vitro and in vivo...
November 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/27725262/molecular-cloning-and-characterization-of-pten-in-the-orange-spotted-grouper-epinephelus-coioides
#10
Sheng-Wei Luo, Wei-Na Wang, Ren-Chong Xie, Fu-Xing Xie, Jing-Rong Kong, Yu-Chao Xiao, Di Huang, Zuo-Ming Sun, Yuan Liu, Cong Wang
PTEN is a key tumor suppressor gene that can play a regulatory role in the cellular proliferation, survival and apoptosis. In this study, the full-length PTEN (EcPTEN) was obtained, containing a 5'UTR of 745 bp, an ORF of 1269 bp and a 3'UTR of 106 bp. The EcPTEN gene encoded a polypeptide of 422 amino acids with an estimated molecular mass of 49.14 KDa and a predicted isoelectric point (pI) of 6.34. The deduced amino acid sequence analysis showed that EcPTEN comprised the conserved residues and the characteristic domains known to the critical functionality of PTEN...
October 7, 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27698374/sleep-duration-daytime-napping-markers-of-obstructive-sleep-apnea-and-stroke-in-a-population-of-southern-china
#11
Ye Wen, Fu-Hua Pi, Pi Guo, Wen-Ya Dong, Yu-Qing Xie, Xiang-Yu Wang, Fang-Fang Xia, Shao-Jie Pang, Yan-Chun Wu, Yuan-Yuan Wang, Qing-Ying Zhang
Sleep habits are associated with stroke in western populations, but this relation has been rarely investigated in China. Moreover, the differences among stroke subtypes remain unclear. This study aimed to explore the associations of total stroke, including ischemic and hemorrhagic type, with sleep habits of a population in southern China. We performed a case-control study in patients admitted to the hospital with first stroke and community control subjects. A total of 333 patients (n = 223, 67.0%, with ischemic stroke; n = 110, 23...
October 4, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27692951/predictors-of-survival-in-adults-undergoing-extracorporeal-membrane-oxygenation-with-severe-infections
#12
Aristine Cheng, Hsin-Yun Sun, Mao-Song Tsai, Wen-Je Ko, Pi-Ru Tsai, Fu-Chang Hu, Yee-Chun Chen, Shan-Chwen Chang
BACKGROUND: To identify novel factors associated with the survival of septic adults receiving extracorporeal membrane oxygenation (ECMO) to improve patient selection and outcomes. METHODS: Cases were identified from our ECMO registry from 2001 to 2011 if they were ≥16 years and received ECMO for life-threatening sepsis. RESULTS: A total of 151 adults with a median (25th-75th percentile) age of 51 (37-63) years were analyzed. Pneumonia (50%), myocarditis (20%), and primary bloodstream infections (15%) were the main types of infection, caused by predominantly nonfermentative Gram-negative bacteria (NFGNB) (26%), Enterobacteriaceae (24%), and Gram-positive cocci (21%)...
August 30, 2016: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/27690188/machine-washable-textile-triboelectric-nanogenerators-for-effective-human-respiratory-monitoring-through-loom-weaving-of-metallic-yarns
#13
Zhizhen Zhao, Casey Yan, Zhaoxian Liu, Xiuli Fu, Lian-Mao Peng, Youfan Hu, Zijian Zheng
Textile triboelectric nanogenerators for human respiratory monitoring with machine washability are developed through loom weaving of Cu-PET and PI-Cu-PET yarns. Triboelectric charges are generated at the yarn crisscross intersections to achieve a maximum short circuit current density of 15.50 mA m(-2) . By integrating into a chest strap, human respiratory rate and depth can be monitored.
September 30, 2016: Advanced Materials
https://www.readbyqxmd.com/read/27677293/a-quinone-containing-compound-enhances-camptothecin-induced-apoptosis-of-lung-cancer-through-modulating-endogenous-ros-and-erk-signaling
#14
Han-Lin Chou, Yao Fong, Chi-Ku Wei, Eing-Mei Tsai, Jeff Yi-Fu Chen, Wen-Tsan Chang, Chang-Yi Wu, Hurng-Wern Huang, Chien-Chih Chiu
The natural compound camptothecin (CPT) derivatives have widely been used for anti-cancer treatments, including lung cancer. However, many chemoresistant cancer cells often develop a relatively higher threshold for inducing apoptosis, causing a limited efficacy of anti-cancer drugs. Likewise, lung cancer cells acquire chemoresistance against CPT analogs, such as irinotecan and topotecan, finally resulting in an unsatisfied outcome and poor prognosis of lung cancer patients. TFPP is a quinone-containing compound as a candidate for CPT-based combination chemotherapy...
September 27, 2016: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/27669520/modeling-periodic-impulsive-effects-on-online-tv-series-diffusion
#15
Peihua Fu, Anding Zhu, Qiwen Fang, Xi Wang
BACKGROUND: Online broadcasting substantially affects the production, distribution, and profit of TV series. In addition, online word-of-mouth significantly affects the diffusion of TV series. Because on-demand streaming rates are the most important factor that influences the earnings of online video suppliers, streaming statistics and forecasting trends are valuable. In this paper, we investigate the effects of periodic impulsive stimulation and pre-launch promotion on on-demand streaming dynamics...
2016: PloS One
https://www.readbyqxmd.com/read/27634172/an-overview-of-chemical-inhibitors-of-the-nrf2-are-signaling-pathway-and-their-potential-applications-in-cancer-therapy
#16
Jiayu Zhu, Huihui Wang, Feng Chen, Jingqi Fu, Yuanyuan Xu, Yongyong Hou, Henry H Kou, Cheng Zhai, M Bud Nelson, Qiang Zhang, Melvin E Andersen, Jingbo Pi
The Nuclear factor erythroid 2-related factor 2 (Nrf2) is a key transcription factor regulating a wide array of genes for antioxidant and detoxification enzymes in response to oxidative and xenobiotic stress. A large number of Nrf2-antioxidant response element (ARE) activators have been screened for use as chemopreventive agents in oxidative stress-related diseases and even cancer. However, constitutive activation of Nrf2 occurs in a variety of cancers. Aberrant activation of Nrf2 is correlated with cancer progression, chemoresistance, and radioresistance...
September 12, 2016: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/27621033/quercetin-nanoparticles-induced-autophagy-and-apoptosis-through-akt-erk-caspase-3-signaling-pathway-in-human-neuroglioma-cells-in-vitro-and-in-vivo
#17
Miao Lou, Li-Na Zhang, Pei-Gang Ji, Fu-Qiang Feng, Jing-Hui Liu, Chen Yang, Bao-Fu Li, Liang Wang
Neuroglioma is a complex neuroglial tumor involving dysregulation of many biological pathways at multiple levels. Quercetin is a potent cancer therapeutic agent presented in fruit and vegetables, preventing tumor proliferation, and is a well known cancer therapeutic agent and autophagy mediator. Recent studies showed that drug delivery by nanoparticles have enhanced efficacy with reduced side effects. In this regard, gold-quercetin into poly (dl-lactide-co-glycolide) nanoparticles was examined. In the present study, quercetin nanoparticle induced cell autophagy and apoptosis in human neuroglioma cell was investigated...
September 9, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27566027/prognostic-factors-and-adjuvant-therapy-on-survival-in-early-stage-cervical-adenocarcinoma-adenosquamous-carcinoma-after-primary-radical-surgery-a-taiwanese-gynecologic-oncology-group-tgog-study
#18
REVIEW
Nae-Fang Twu, Yu-Che Ou, Cheng-I Liao, Wei-Yang Chang, Lan-Yan Yang, Yun-Hsin Tang, Tze-Chien Chen, Chi-Hau Chen, Tze-Ho Chen, Lain-Shung Yeh, Shih-Tien Hsu, Yu-Chieh Chen, Cheng-Chang Chang, Ya-Min Cheng, Chia-Yen Huang, Fu-Shing Liu, Yue-Shan Lin, Sheng-Mou Hsiao, Yuan-Yee Kan, Chyong-Huey Lai
OBJECTIVE: We aimed to identify prognostic factors of early-stage cervical adenocarcinoma (AC) and adenosquamous carcinoma (ASC) treated with primary radical surgery, and to evaluate the impact of postoperative adjuvant therapy on outcome. METHODS: The clinical-pathological data of all patients (n = 1132) with stages I-II cervical AC/ASC treated with primary radical surgery at the member hospitals of the Taiwanese Gynecologic Oncology Group were retrospectively reviewed...
September 2016: Surgical Oncology
https://www.readbyqxmd.com/read/27564014/primary-intestinal-extranodal-natural-killer-t-cell-lymphoma-nasal-type-a-comprehensive-clinicopathological-analysis-of-55-cases
#19
Bao-Hua Yu, Ruo-Hong Shui, Wei-Qi Sheng, Chao-Fu Wang, Hong-Fen Lu, Xiao-Yan Zhou, Xiong-Zeng Zhu, Xiao-Qiu Li
PURPOSE: To investigate the clinicopathological features, survival and prognostic factors of primary intestinal extranodal natural killer/T-cell lymphoma, nasal type (PI-ENKTCL). METHODS: Clinical and histological characteristics of PI-ENKTCL cases were retrospectively evaluated. Immunohistochemical phenotype and status of Epstein-Barr virus (EBV) and T-cell receptor (TCR) gene rearrangement were examined. The overall survival and prognostic parameters were also analyzed...
2016: PloS One
https://www.readbyqxmd.com/read/27546777/nationwide-epidemiology-and-prognosis-of-dialysis-requiring-acute-kidney-injury-nep-aki-d-study-design-and-methods
#20
Chih-Chung Shiao, Pei-Chen Wu, Vin-Cent Wu, Jui-Hsiang Lin, Heng-Chih Pan, Ya-Fei Yang, Tai-Shuan Lai, Tao-Min Huang, Che-Hsiung Wu, Wei-Shun Yang, Chih-Jen Wu, Chih-Chin Kao, Chiao-Yin Sun, Chun-Te Huang, Kuo-Hua Lee, Chan-Yu Lin, Te-Chuan Chen, Fu-Chang Hu, Hung-Hsiang Liou, Kuo-Cheng Lu, Kuo-Liong Chien, Jian-Jhong Wang, Wei-Chih Kan, Feng-Chi Kuo, Hugo You-Hsien Lin, Cheng-Min Chen, Zi-Hong You, Jen-Pi Tsai, Chih-Jen Weng, Hung-Yuan Chen, Chao-Fu Chang, Wen-Ding Hsu, Mai-Szu Wu, Chiu-Ching Huang, Kwan-Dun Wu
AIM: Acute kidney injury (AKI) carries an increasing incidence rate worldwide and increases the risk of developing end-stage renal disease (ESRD) as well as the medical expenses during the post-AKI course. The Taiwan Consortium for Acute Kidney Injury and Renal Diseases (CAKs) has thus launched a nationwide epidemiology and prognosis of dialysis-requiring acute kidney injury (NEP-AKI-D) study, which prospectively enrols critically ill patients with AKI. Through thoroughly evaluating the risk and prognostic factors of AKI, we hope to lower the incidence of AKI and ESRD from the perspective of AKI-ESRD interaction...
September 2016: Nephrology
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