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https://www.readbyqxmd.com/read/28515735/time-course-transcriptome-analysis-of-compatible-and-incompatible-pollen-stigma-interactions-in-brassica-napus-l
#1
Tong Zhang, Changbin Gao, Yao Yue, Zhiquan Liu, Chaozhi Ma, Guilong Zhou, Yong Yang, Zhiqiang Duan, Bing Li, Jing Wen, Bin Yi, Jinxiong Shen, Jinxing Tu, Tingdong Fu
Brassica species exhibit both compatible and incompatible pollen-stigma interactions, however, the underlying molecular mechanisms remain largely unknown. Here, RNA-seq technology was applied in a comprehensive time-course experiment (2, 5, 10, 20, and 30 min) to explore gene expression during compatible/incompatible pollen-stigma interactions in stigma. Moderate changes of gene expression were observed both in compatible pollination (PC) and incompatible pollination (PI) within 10 min, whereas drastic changes showed up by 30 min, especially in PI...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28489576/intraoperative-contrast-enhanced-ultrasonography-for-microcirculatory-evaluation-in-rhesus-monkey-with-spinal-cord-injury
#2
Lin Huang, Keng Chen, Fu-Chao Chen, Hui-Yong Shen, Ji-Chao Ye, Zhao-Peng Cai, Xi Lin
This study tried to quantify spinal cord perfusion by using contrast-enhanced ultrasound (CEUS) in rhesus monkey models with acute spinal cord injury. Acute spinal cord perfusion after injury was detected by CEUS, coupling with conventional ultrasound (US) and Color Doppler US (CDFI). Time-intensity curves and perfusion parameters were obtained by autotracking contrast quantification (ACQ) software in the epicenter and adjacent regions of injury, respectively. Neurological and histological examinations were performed to confirm the severity of injury...
April 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/28454264/luteolin-a-novel-p90-ribosomal-s6-kinase-inhibitor-suppresses-proliferation-and-migration-in-leukemia-cells
#3
Lan Deng, Ling Jiang, Xianghua Lin, Kuo-Fu Tseng, Zhigang Lu, Xiuju Wang
Ribosomal S6 kinases (RSKs) are directly regulated by extracellular signal-regulated kinase (ERK) signaling and are implicated in cell growth, survival, motility and senescence. The present study observed that RSK1 was overexpressed in primary untreated leukemia patient bone marrow samples compared with the expression at the complete remission stage, using reverse transcription-quantitative polymerase chain reaction (RT-qPCR). In addition, a high RSK1 expression (relative expression ≥10) was associated with a significantly shorter overall survival (P=0...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28444744/dual-cdk4-6-inhibition-by-pd-0332991-induces-apoptosis-and-senescence-in-esophageal-squamous-cell-carcinoma-cells
#4
Liang Chen, Jingxuan Pan
BACKGROUND AND PURPOSE: Aberrant activation of Cyclin D1-CDK4/6-Rb signaling pathway is common in esophageal squamous cell carcinoma (ESCC). PD-0332991, a highly specific inhibitor of CDK4/6, has been showed potent antitumor activity against multiple types of cancer. The purpose of this study was to examine the in vitro and in vivo antineoplastic effect of PD-0332991 against the growth and metastasis in ESCC cells. EXPERIMENTAL APPROACH: Cell viability and synergy between PD-0332991 and 5-fluorouracil/Cisplatin were measured by MTS assay and CalcuSyn software, respectively...
April 25, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28437343/spinopelvic-alignment-by-different-surgical-methods-in-the-treatment-of-degenerative-sagittal-imbalance-of-the-lumbar-spine
#5
Dong-Gune Chang, Kee-Yong Ha, Young-Hoon Kim, Eun-Whan Lee
STUDY DESIGN: A retrospective comparative study. OBJECTIVE: To compare pedicle subtraction osteotomy (PSO) and iliac fixation (ILF) without osteotomy as methods of correcting lumbar spine deformities due to degenerative sagittal imbalance (DSI) through the evaluation of the changes in spinopelvic alignment. SUMMARY OF BACKGROUND DATA: Many papers have reported the surgical results after PSO and ILF for patients with fixed adult deformities...
May 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28421411/seleno-short-chain-chitosan-induces-apoptosis-in-human-non-small-cell-lung-cancer-a549-cells-through-ros-mediated-mitochondrial-pathway
#6
Yana Zhao, Shaojing Zhang, Pengfei Wang, Shengnan Fu, Di Wu, Anjun Liu
Seleno-short-chain chitosan (SSCC) is a synthesized chitosan derivative. In this study, antitumor activity and underlying mechanism of SSCC on human non-small-cell lung cancer A549 cells were investigated in vitro. The MTT assay showed that SSCC could inhibit cell viability in a dose- and time-dependent manner, and 200 μg/ml SSCC exhibited significantly toxic effects on A549 cells. The cell cycle assay showed that SSCC triggered S phase cell cycle arrest in a dose- and time-dependent manner, which was related to a downregulation of S phase associated cyclin A...
April 18, 2017: Cytotechnology
https://www.readbyqxmd.com/read/28416328/hepatoprotective-mongolian-prescription-ii-enhances-the-antitumor-effects-of-chemotherapeutics-in-hepatocellular-carcinoma-xenografts
#7
A Nanda, Qimuge Suyila, Li Xian, Su Xiulan
Hepatoprotective Mongolian prescription II (MPII), a mixture of 18 different medicinal herbs, significantly inhibited the growth of human liver cancer cell lines Huh-7 and HepG2 in vitro with different concentrations; MPII (6mg/mL) inhibited cell proliferation by 80.48%. MPII induced apoptosis in both cell lines, which was observed by light microscopy and flow cytometry. MPII-induced apoptosis and G0/G1 cell cycle arrest were quantified by Annexin V-FITC/PI staining and flow cytometry. At the molecular level, MPII induced caspase-3, caspase-8, caspase-9, and cytochrome c gene expression...
January 18, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28411308/the-effect-of-mir-200c-inhibition-on-chemosensitivity-5-fluorouracil-in-colorectal-cancer
#8
Korosh Heydari, Massoud Saidijam, Mohammad Reza Sharifi, Fatemeh Karimi Dermani, Sara Soleimani Asl, Nooshin Shabab, Rezvan Najafi
5-Fluorouracil (5-FU) as a chemotherapeutic drug is used to treat colorectal cancer (CRC). However, 5-FU is associated with acquired CRC resistance, which decreases the therapeutic potential of 5-FU. Several studies indicated that miR-200c is also involved in chemotherapeutic drug resistance, but the exact mechanism of miR-200c mediated chemoresistance has not yet been fully understood. In this study, we examined the effect of inhibition of miR-200c on the sensitivity of HCT-116 cells to 5-FU. HCT-116 cells were transfected with LNA-anti- miR-200c for 48 h...
April 14, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28387750/bmp6-regulates-proliferation-and-apoptosis-of-human-sertoli-cells-via-smad2-3-and-cyclin-d1-pathway-and-dach1-and-tfap2a-activation
#9
Hong Wang, Qingqing Yuan, Min Sun, Minghui Niu, Liping Wen, Hongyong Fu, Fan Zhou, Zheng Chen, Chencheng Yao, Jingmei Hou, Ruinan Shen, Qisheng Lin, Wenjie Liu, Ruobing Jia, Zheng Li, Zuping He
Sertoli cells are essential for regulating normal spermatogenesis. However, the mechanisms underlying human Sertoli cell development remain largely elusive. Here we examined the function and signaling pathways of BMP6 in regulating human Sertoli cells. RT-PCR, immunocytochemistry and Western blots revealed that BMP6 and its multiple receptors were expressed in human Sertoli cells. CCK-8 and EDU assays showed that BMP6 promoted the proliferation of Sertoli cells. Conversely, BMP6 siRNAs inhibited the division of these cells...
April 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28363705/relationship-between-plasma-adropin-levels-and-body-composition-and-lipid-characteristics-amongst-young-adolescents-in-taiwan
#10
Jin-Biou Chang, Nain-Feng Chu, Fu-Huang Lin, Jhu-Ting Hsu, Pi-Yun Chen
Adropin is a 76 amino acid peptide hormone with a molecular weight of 4999.9Da that may be associated with energy homeostasis, insulin resistance and lipid metabolism in mice and human. There is only a few studies that examine plasma adropin levels and body composition in children. This study is to evaluate the relationship between plasma adropin levels, body composition and lipid variables amongst young adolescents in Taiwan. We examined 492 adolescents (269 females and 223 males) ranging from 12 to 15 years old, with a mean age of 13...
March 28, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/28335216/investigation-of-the-structural-electrical-and-optical-properties-of-the-nano-scale-gzo-thin-films-on-glass-and-flexible-polyimide-substrates
#11
Fang-Hsing Wang, Kun-Neng Chen, Chao-Ming Hsu, Min-Chu Liu, Cheng-Fu Yang
In this study, Ga₂O₃-doped ZnO (GZO) thin films were deposited on glass and flexible polyimide (PI) substrates at room temperature (300 K), 373 K, and 473 K by the radio frequency (RF) magnetron sputtering method. After finding the deposition rate, all the GZO thin films with a nano-scale thickness of about 150 ± 10 nm were controlled by the deposition time. X-ray diffraction patterns indicated that the GZO thin films were not amorphous and all exhibited the (002) peak, and field emission scanning electron microscopy showed that only nano-scale particles were observed...
May 10, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28322392/theoretical-analysis-of-electrochromism-under-redox-of-bis-3-thienyl-2-thienyl-hexafluorocyclopentene-effects-of-charged-and-substituted-systems
#12
Zhi-Xiang Zhang, Pi-Xia Wang, Fu-Quan Bai, Chui-Peng Kong, Hong-Xing Zhang
Electrochromism with the ring-closing or ring-opening isomerization of substituted and unsubstituted bis(3-thienyl)/(2-thienyl)hexafluorocyclopentene is discussed using the DFT method. In the neutral ground state, bond making and breaking between two reactive C atoms on thienyls are thermodynamically forbidden. Under redox conditions, the gain or loss of electrons can have a significant effect on the frontier molecular orbital distribution of both open- and closed-ring isomers, particularly in reactive sites...
March 21, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28288932/inhibition-of-jnk-by-pi-class-of-glutathione-s-transferase-through-pka-creb-pathway-is-associated-with-carnosic-acid-protection-against-6-hydroxydopamine-induced-apoptosis
#13
Chia-Yuan Lin, Ru-Huei Fu, Ruey-Hwang Chou, Jing-Hsien Chen, Chi-Rei Wu, Shu-Wei Chang, Chia-Wen Tsai
Pi class of glutathione S-transferase (GST) is known to suppress c-Jun N-terminal kinase (JNK)-related apoptosis through protein-protein interactions. Moreover, signaling by PKA/cAMP response element binding protein (CREB) is necessary for GSTP up-regulation. This study explored whether carnosic acid (CA) from rosemary prevents 6-hydroxydopamine (6-OHDA)-induced neurotoxicity by inhibition of JNK through GSTP via PKA/CREB signaling. Results indicated that the GSTP protein was increased in SH-SY5Y cells treated with CA for 18 and 24 h...
March 10, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28213110/effect-of-chinese-herbal-medicine-on-stroke-patients-with-type-2-diabetes
#14
Fuu-Jen Tsai, Tsung-Jung Ho, Chi-Fung Cheng, Xiang Liu, Hsinyi Tsang, Ting-Hsu Lin, Chiu-Chu Liao, Shao-Mei Huang, Ju-Pi Li, Cheng-Wen Lin, Jaung-Geng Lin, Jung-Chun Lin, Chih-Chien Lin, Wen-Miin Liang, Ying-Ju Lin
ETHNOPHARMACOLOGICAL RELEVANCE: Complications of type 2 diabetes (T2D) include stroke, which is a cerebrovascular disturbance characterized by reduced blood flow in the brain, leading to death or physical disability. Chinese herbal medicine (CHM) has been widely used in ancient China for the treatment of diabetes and stroke by supplementing Qi and activating blood circulation. AIM OF THE STUDY: This study aimed to investigate the frequencies and patterns of CHM treatment for stroke patients with T2D and the outcomes of long-term use in Taiwan...
March 22, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28185447/highly-efficient-deep-blue-electroluminescence-from-a-charge-transfer-emitter-with-stable-donor-skeleton
#15
Wen-Cheng Chen, Yi Yuan, Shao-Fei Ni, Ze-Lin Zhu, Jinfeng Zhang, Zuo-Quan Jiang, Liang-Sheng Liao, Fu-Lung Wong, Chun-Sing Lee
Organic materials containing arylamines have been widely used as hole-transporting materials as well as emitters in organic light-emitting devices (OLEDs). However, it has been pointed out that the C-N bonds in these arylamines can easily suffer from degradation in excited states, especially in deep-blue OLEDs. In this work, phenanthro[9,10-d]imidazole (PI) is proposed as a potential donor with higher stability than those of arylamines. Using PI as the donor, a donor-acceptor type deep-blue fluorophore 1-phenyl-2-(4″-(1-phenyl-1H-benzo[d]imidazol-2-yl)-[1,1':4',1″-terphenyl]-4-yl)-1H-phenanthro[9,10-d]imidazole (BITPI) is designed and synthesized...
March 1, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28159694/molecular-cloning-characterization-and-expression-analysis-of-caspase-3-from-the-oriental-river-prawn-macrobrachium-nipponense-when-exposed-to-acute-hypoxia-and-reoxygenation
#16
Shengming Sun, Fujun Xuan, Hongtuo Fu, Jian Zhu, Xianping Ge, Xugan Wu
Caspases are present in the cytosol as inactive proenzymes but become activated when apoptosis is initiated, playing an essential role at various stages of the process. In this study, a caspase-3 (Mncaspase-3c) was cloned from gill of the oriental river prawn Macrobrachium nipponense by reverse-transcription polymerase chain reaction and rapid amplification of cDNA ends, and its properties were characterized. The 1730-bp cDNA contained an open reading frame of 1566 bp, a 123-bp 5'-untranslated region (UTR), and a 41-bp 3'-UTR containing a poly(A) tail...
March 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28111763/cytochrome-p450-reaction-phenotyping-and-inhibition-and-induction-studies-of-pinostrobin-in-human-liver-microsomes-and-hepatocytes
#17
Shengnan Tan, Zhimin Dong, Jiashuo Zhang, Thomas Efferth, Yujie Fu, Xin Hua
Pinostrobin (PI, 5-hydroxy-7-methoxyflavanone) is a natural flavonoid known for its rich pharmacological activities. The objective of this study was to identify the human liver cytochrome P450 (CYP450) isoenzymes involved in the metabolism of PI. A single hydoxylated metabolite was obtained from PI after an incubation with pooled human liver microsomes (HLMs). The relative contributions of different CYP450s were evaluated using CYP450-selective inhibitors in HLMs and recombinant human CYP450 enzymes, and the results revealed the major involvement of CYP1A2, CYP2C9 and CYP2E1 in PI metabolism...
November 7, 2016: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28107470/development-of-a-blocking-elisa-using-a-monoclonal-antibody-to-a-dominant-epitope-in-non-structural-protein-3a-of-foot-and-mouth-disease-virus-as-a-matching-test-for-a-negative-marker-vaccine
#18
Yuanfang Fu, Pinghua Li, Yimei Cao, Na Wang, Pu Sun, Qian Shi, Xincheng Ji, Huifang Bao, Dong Li, Yingli Chen, Xingwen Bai, Xueqing Ma, Jing Zhang, Zengjun Lu, Zaixin Liu
Foot-and-mouth disease (FMD) is a devastating animal disease. Strategies for differentiation of infected from vaccinated animals (DIVA) remain very important for controlling disease. Development of an epitope-deleted marker vaccine and accompanying diagnostic method will improve the efficiency of DIVA. Here, a monoclonal antibody (Mab) was found to recognize a conserved "AEKNPLE" epitope spanning amino acids 109-115 of non-structural protein (NSP) 3A of foot-and-mouth disease virus (FMDV; O/Tibet/CHA/99 strain), which could be deleted by a reverse-genetic procedure...
2017: PloS One
https://www.readbyqxmd.com/read/28027979/the-impairment-of-glucose-stimulated-insulin-secretion-in-pancreatic-%C3%AE-cells-caused-by-prolonged-glucotoxicity-and-lipotoxicity-is-associated-with-elevated-adaptive-antioxidant-response
#19
Jingqi Fu, Qi Cui, Bei Yang, Yongyong Hou, Huihui Wang, Yuanyuan Xu, Difei Wang, Qiang Zhang, Jingbo Pi
Type 2 diabetes (T2D) is a progressive disease characterized by sustained hyperglycemia and is frequently accompanied by hyperlipidemia. Deterioration of β-cell function in T2D patients may be caused, in part, by long-term exposure to high concentrations of glucose and/or lipids. We developed systems to study how chronic glucotoxicity and lipotoxicity might be linked to the impairment of glucose-stimulated insulin secretion (GSIS) machinery in pancreatic β-cells. INS-1 (832/13) were exposed to glucose and/or palmitate for up to 10 weeks...
February 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/27998015/efficacy-immunogenicity-and-safety-of-the-hpv-16-18-as04-adjuvanted-vaccine-in-chinese-women-aged-18-25%C3%A2-years-event-triggered-analysis-of-a-randomized-controlled-trial
#20
Feng-Cai Zhu, Shang-Ying Hu, Ying Hong, Yue-Mei Hu, Xun Zhang, Yi-Ju Zhang, Qin-Jing Pan, Wen-Hua Zhang, Fang-Hui Zhao, Cheng-Fu Zhang, Xiaoping Yang, Jia-Xi Yu, Jiahong Zhu, Yejiang Zhu, Feng Chen, Qian Zhang, Hong Wang, Changrong Wang, Jun Bi, Shiyin Xue, Lingling Shen, Yan-Shu Zhang, Yunkun He, Haiwen Tang, Naveen Karkada, Pemmaraju Suryakiran, Dan Bi, Frank Struyf
We previously reported the results of a phase II/III, double-blind, randomized controlled study in Chinese women (NCT00779766) showing a 94.2% (95% confidence interval: 62.7-99.9) HPV-16/18 AS04-adjuvanted vaccine efficacy (VE) against cervical intraepithelial neoplasia grade 1 or higher (CIN1+) and/or 6-month (M) persistent infection (PI) with a mean follow-up of <2 years, and immunogenicity until 7 months post-dose 1. Here, we report efficacy and safety results from an event-triggered analysis with ~3 years longer follow-up, and immunogenicity until M24...
January 2017: Cancer Medicine
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