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Guangxian Zhang, Xiancheng Zeng, Ren Zhang, Juan Liu, Weici Zhang, Yujun Zhao, Xiaoyuan Zhang, Zhixue Wu, Yuhui Tan, Yingya Wu, Biaoyan Du
BACKGROUND: Hepatocellular carcinoma (HCC) is the most commonly diagnosed malignancy of the liver, occurs frequently in the setting of chronic liver injury. Although multiple therapeutic approaches are available, the prognosis of patients with HCC remains poor. Dioscin is a natural steroid saponin that presents in various plants. The anti-cancer and anti-fibrotic effects have been extensively reported. However, the effect of dioscin on HCC remains unclear. We aimed to investigate the anti-HCC properties of dioscin in vitro and in vivo...
November 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
Sheng-Wei Luo, Wei-Na Wang, Ren-Chong Xie, Fu-Xing Xie, Jing-Rong Kong, Yu-Chao Xiao, Di Huang, Zuo-Ming Sun, Yuan Liu, Cong Wang
PTEN is a key tumor suppressor gene that can play a regulatory role in the cellular proliferation, survival and apoptosis. In this study, the full-length PTEN (EcPTEN) was obtained, containing a 5'UTR of 745 bp, an ORF of 1269 bp and a 3'UTR of 106 bp. The EcPTEN gene encoded a polypeptide of 422 amino acids with an estimated molecular mass of 49.14 KDa and a predicted isoelectric point (pI) of 6.34. The deduced amino acid sequence analysis showed that EcPTEN comprised the conserved residues and the characteristic domains known to the critical functionality of PTEN...
October 7, 2016: Fish & Shellfish Immunology
Ye Wen, Fu-Hua Pi, Pi Guo, Wen-Ya Dong, Yu-Qing Xie, Xiang-Yu Wang, Fang-Fang Xia, Shao-Jie Pang, Yan-Chun Wu, Yuan-Yuan Wang, Qing-Ying Zhang
Sleep habits are associated with stroke in western populations, but this relation has been rarely investigated in China. Moreover, the differences among stroke subtypes remain unclear. This study aimed to explore the associations of total stroke, including ischemic and hemorrhagic type, with sleep habits of a population in southern China. We performed a case-control study in patients admitted to the hospital with first stroke and community control subjects. A total of 333 patients (n = 223, 67.0%, with ischemic stroke; n = 110, 23...
October 4, 2016: Scientific Reports
Aristine Cheng, Hsin-Yun Sun, Mao-Song Tsai, Wen-Je Ko, Pi-Ru Tsai, Fu-Chang Hu, Yee-Chun Chen, Shan-Chwen Chang
BACKGROUND: To identify novel factors associated with the survival of septic adults receiving extracorporeal membrane oxygenation (ECMO) to improve patient selection and outcomes. METHODS: Cases were identified from our ECMO registry from 2001 to 2011 if they were ≥16 years and received ECMO for life-threatening sepsis. RESULTS: A total of 151 adults with a median (25th-75th percentile) age of 51 (37-63) years were analyzed. Pneumonia (50%), myocarditis (20%), and primary bloodstream infections (15%) were the main types of infection, caused by predominantly nonfermentative Gram-negative bacteria (NFGNB) (26%), Enterobacteriaceae (24%), and Gram-positive cocci (21%)...
August 30, 2016: Journal of Thoracic and Cardiovascular Surgery
Zhizhen Zhao, Casey Yan, Zhaoxian Liu, Xiuli Fu, Lian-Mao Peng, Youfan Hu, Zijian Zheng
Textile triboelectric nanogenerators for human respiratory monitoring with machine washability are developed through loom weaving of Cu-PET and PI-Cu-PET yarns. Triboelectric charges are generated at the yarn crisscross intersections to achieve a maximum short circuit current density of 15.50 mA m(-2) . By integrating into a chest strap, human respiratory rate and depth can be monitored.
September 30, 2016: Advanced Materials
Han-Lin Chou, Yao Fong, Chi-Ku Wei, Eing-Mei Tsai, Jeff Yi-Fu Chen, Wen-Tsan Chang, Chang-Yi Wu, Hurng-Wern Huang, Chien-Chih Chiu
The natural compound camptothecin (CPT) derivatives have widely been used for anti-cancer treatments, including lung cancer. However, many chemoresistant cancer cells often develop a relatively higher threshold for inducing apoptosis, causing a limited efficacy of anti-cancer drugs. Likewise, lung cancer cells acquire chemoresistance against CPT analogs, such as irinotecan and topotecan, finally resulting in an unsatisfied outcome and poor prognosis of lung cancer patients. TFPP is a quinone-containing compound as a candidate for CPT-based combination chemotherapy...
September 27, 2016: Archivum Immunologiae et Therapiae Experimentalis
Peihua Fu, Anding Zhu, Qiwen Fang, Xi Wang
BACKGROUND: Online broadcasting substantially affects the production, distribution, and profit of TV series. In addition, online word-of-mouth significantly affects the diffusion of TV series. Because on-demand streaming rates are the most important factor that influences the earnings of online video suppliers, streaming statistics and forecasting trends are valuable. In this paper, we investigate the effects of periodic impulsive stimulation and pre-launch promotion on on-demand streaming dynamics...
2016: PloS One
Jiayu Zhu, Huihui Wang, Feng Chen, Jingqi Fu, Yuanyuan Xu, Yongyong Hou, Henry H Kou, Cheng Zhai, M Bud Nelson, Qiang Zhang, Melvin E Andersen, Jingbo Pi
The Nuclear factor erythroid 2-related factor 2 (Nrf2) is a key transcription factor regulating a wide array of genes for antioxidant and detoxification enzymes in response to oxidative and xenobiotic stress. A large number of Nrf2-antioxidant response element (ARE) activators have been screened for use as chemopreventive agents in oxidative stress-related diseases and even cancer. However, constitutive activation of Nrf2 occurs in a variety of cancers. Aberrant activation of Nrf2 is correlated with cancer progression, chemoresistance, and radioresistance...
September 12, 2016: Free Radical Biology & Medicine
Miao Lou, Li-Na Zhang, Pei-Gang Ji, Fu-Qiang Feng, Jing-Hui Liu, Chen Yang, Bao-Fu Li, Liang Wang
Neuroglioma is a complex neuroglial tumor involving dysregulation of many biological pathways at multiple levels. Quercetin is a potent cancer therapeutic agent presented in fruit and vegetables, preventing tumor proliferation, and is a well known cancer therapeutic agent and autophagy mediator. Recent studies showed that drug delivery by nanoparticles have enhanced efficacy with reduced side effects. In this regard, gold-quercetin into poly (dl-lactide-co-glycolide) nanoparticles was examined. In the present study, quercetin nanoparticle induced cell autophagy and apoptosis in human neuroglioma cell was investigated...
September 9, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Nae-Fang Twu, Yu-Che Ou, Cheng-I Liao, Wei-Yang Chang, Lan-Yan Yang, Yun-Hsin Tang, Tze-Chien Chen, Chi-Hau Chen, Tze-Ho Chen, Lain-Shung Yeh, Shih-Tien Hsu, Yu-Chieh Chen, Cheng-Chang Chang, Ya-Min Cheng, Chia-Yen Huang, Fu-Shing Liu, Yue-Shan Lin, Sheng-Mou Hsiao, Yuan-Yee Kan, Chyong-Huey Lai
OBJECTIVE: We aimed to identify prognostic factors of early-stage cervical adenocarcinoma (AC) and adenosquamous carcinoma (ASC) treated with primary radical surgery, and to evaluate the impact of postoperative adjuvant therapy on outcome. METHODS: The clinical-pathological data of all patients (n = 1132) with stages I-II cervical AC/ASC treated with primary radical surgery at the member hospitals of the Taiwanese Gynecologic Oncology Group were retrospectively reviewed...
September 2016: Surgical Oncology
Bao-Hua Yu, Ruo-Hong Shui, Wei-Qi Sheng, Chao-Fu Wang, Hong-Fen Lu, Xiao-Yan Zhou, Xiong-Zeng Zhu, Xiao-Qiu Li
PURPOSE: To investigate the clinicopathological features, survival and prognostic factors of primary intestinal extranodal natural killer/T-cell lymphoma, nasal type (PI-ENKTCL). METHODS: Clinical and histological characteristics of PI-ENKTCL cases were retrospectively evaluated. Immunohistochemical phenotype and status of Epstein-Barr virus (EBV) and T-cell receptor (TCR) gene rearrangement were examined. The overall survival and prognostic parameters were also analyzed...
2016: PloS One
Chih-Chung Shiao, Pei-Chen Wu, Vin-Cent Wu, Jui-Hsiang Lin, Heng-Chih Pan, Ya-Fei Yang, Tai-Shuan Lai, Tao-Min Huang, Che-Hsiung Wu, Wei-Shun Yang, Chih-Jen Wu, Chih-Chin Kao, Chiao-Yin Sun, Chun-Te Huang, Kuo-Hua Lee, Chan-Yu Lin, Te-Chuan Chen, Fu-Chang Hu, Hung-Hsiang Liou, Kuo-Cheng Lu, Kuo-Liong Chien, Jian-Jhong Wang, Wei-Chih Kan, Feng-Chi Kuo, Hugo You-Hsien Lin, Cheng-Min Chen, Zi-Hong You, Jen-Pi Tsai, Chih-Jen Weng, Hung-Yuan Chen, Chao-Fu Chang, Wen-Ding Hsu, Mai-Szu Wu, Chiu-Ching Huang, Kwan-Dun Wu
AIM: Acute kidney injury (AKI) carries an increasing incidence rate worldwide and increases the risk of developing end-stage renal disease (ESRD) as well as the medical expenses during the post-AKI course. The Taiwan Consortium for Acute Kidney Injury and Renal Diseases (CAKs) has thus launched a nationwide epidemiology and prognosis of dialysis-requiring acute kidney injury (NEP-AKI-D) study, which prospectively enrols critically ill patients with AKI. Through thoroughly evaluating the risk and prognostic factors of AKI, we hope to lower the incidence of AKI and ESRD from the perspective of AKI-ESRD interaction...
September 2016: Nephrology
Shu-Mei Chen, Ying-Ying Li, Chiao-Hui Tu, Nicole Salazar, Yuan-Yun Tseng, Shiang-Fu Huang, Ling-Ling Hsieh, Tai-Ngar Lui
BACKGROUND: Medulloblastoma (MB) is the most common pediatric primary malignant brain tumor. Approximately one-third of MB patients succumb to treatment failure and some survivors suffer detrimental side effects. Hence, the purpose of this study is to explore new therapeutic regimens to overcome chemotherapeutic agent resistance or reduce chemotherapy-induced toxicity. METHODS: We detected the expression of inhibitors of apoptosis proteins (IAPs) in MB and CD133+ MB cell lines and MB tissues using immunoblotting and immunohistochemical staining...
2016: PloS One
Xin Lv, Yuan Liu, Song Zhou, Qiang Wang, Houyun Gu, Xiaoxing Fu, Yi Ding, Bin Zhang, Min Dai
BACKGROUND: Sagittal spinopelvic alignment changes associated with degenerative facet joint arthritis have been assessed in a few studies. It has been documented that patients with facet joint degeneration have higher pelvic incidence, but the relationship between facet joint degeneration and other sagittal spinopelvic alignment parameters is still disputed. Our purpose was to evaluate the correlation between the features of sagittal spinopelvic alignment and facet joint degeneration...
2016: BMC Musculoskeletal Disorders
YoungHyun Shin, Hoyong Lim, Byeong-Sun Choi, Kyung-Chang Kim, Chun Kang, Yong-Soo Bae, Cheol-Hee Yoon
BACKGROUND: Despite the successful inhibition of human immunodeficiency virus type 1 (HIV-1) replication by combination antiretroviral therapy, cells latently infected with HIV-1 remaining in patients are a major obstacle for eradication of HIV-1 infection. The tumor suppressor factor p53 is activated by HIV-1 infection, and restricts HIV-1 replication. However, a therapeutic strategy based on p53 activity has not been considered for elimination of latently infected cells. METHODS: Apoptotic cells were analyzed using flow cytometry with anti-annexin A5-FITC Ab and PI staining upon treatment of anticancer drugs...
2016: Virology Journal
Jian-Wei Xu, Yong Li, Heng-Lin Yang, Jun Zhang, Zai-Xing Zhang, Ya-Ming Yang, Hong-Ning Zhou, Joshua Havumaki, Hua-Xian Li, Hui Liu, Hua Zhou, Xin-Yu Xie, Jia-Xiang Dong, Yue Zhang, Xiao-Ying Sun, Bo Li, Jia-Yin Li, Yang-Hui Tian, Pi-Yu Wang, Ben-Fu Li
BACKGROUND: Implementing effective interventions remain a lot of difficulties along all border regions. The emergence of artemisinin resistance of Plasmodium falciparum strains in the Greater Mekong Subregion is a matter of great concern. China has effectively controlled cross-border transmission of malaria and artemisinin resistance of P. falciparum along the China-Myanmar border. METHODS: A combined quantitative and qualitative study was used to collect data, and then an integrated impact evaluation was conducted to malaria control along the China-Myanmar border during 2007-2013...
2016: Infectious Diseases of Poverty
Jinlong Liu, Shaomin Fu, Lei Yang, Mingda Luan, Fugeng Zhao, Sheng Luan, Wenzhi Lan
To survive in most soils in which inorganic phosphate (Pi) levels are limited and constantly changing, plants universally use the vacuoles as cellular Pi "sink" and "source" to maintain Pi homeostasis. However, the transporters that mediate Pi sequestration into the vacuoles remain unknown. Recently, we and other 2 groups independently identified the members of SPS-MSF family as the candidates for tonoplast Pi transporters in Arabidopsis thaliana and Oryza sativa. We and Liu et al. demonstrated that one of SPS-MSF member, VPT1 (Vacuolar Phosphate Transporter 1), also named as PHT5;1 (Phosphate Transporter 5;1), plays a predominant role in Pi sequestration of vacuoles in Arabidopsis...
August 2, 2016: Plant Signaling & Behavior
Yin Shen, Hong-Yang Zhao, Hai-Jun Wang, Wen-Liang Wang, Li-Zhi Zhang, Rong Fu
The expression changes of Rars gene in ischemia-injured neurons were investigated by detecting its translational product arginyl-tRNA synthetase (ArgRS), and the inhibitory effects of ischemic preconditioning (IPC) on Rars gene were explored. Both IPC model and prolonged ischemia (PI) model were established by using the classic oxygen glucose deprivation (OGD) method. The primary cultured neurons were assigned into the following groups: the experimental group (IPC+PI group), undergoing PI after a short period of IPC; the conditional control group (PI control group), subjected to PI without IPC; blank control group, the normally cultured neurons...
August 2016: Journal of Huazhong University of Science and Technology. Medical Sciences
Yanyan Chen, Yuanyuan Xu, Hongzhi Zheng, Jingqi Fu, Yongyong Hou, Huihui Wang, Qiang Zhang, Masayuki Yamamoto, Jingbo Pi
Nuclear factor E2-related factor 2 (NRF2) and uncoupling protein 2 (UCP2) are indicated to protect from oxidative stress. They also play roles in the homeostasis of glutathione. However, the detailed mechanisms are not well understood. In the present study, we found Nrf2-knockout (Nrf2-KO) mice exhibited altered glutathione homeostasis and reduced expression of various genes involved in GSH biosynthesis, regeneration, utilization and transport in the liver. Ucp2-knockout (Ucp2-KO) mice exhibited altered glutathione homeostasis in the liver, spleen and blood, as well as increased transcript of cystic fibrosis transmembrane conductance regulator in the liver, a protein capable of mediating glutathione efflux...
September 9, 2016: Biochemical and Biophysical Research Communications
Y Fu, M Tang, L Bai, Y Fan
To explore the role of apoptosis inducing factor (AIF) in the apoptosis of retinal pigment epithelium (RPE) cells induced by oxidative stress. RPE cell apoptotic models were constructed by H2O2, Annexin V/PI flow cytometry and MTT assay were used to determine the changes of RPE cell apoptosis and proliferation. The production of reactive oxygen species (ROS) and mitochondrial membrane potential were observed. QRT-PCR and western blot were used to determine the expression of AIF to evaluate whether AIF-mediated non caspase pathway participated in the RPE cell apoptosis induced by H2O2...
2016: Cellular and Molecular Biology
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