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nitrofurantoin

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https://www.readbyqxmd.com/read/29331548/effect-of-outpatient-antibiotics-for-urinary-tract-infections-on-antimicrobial-resistance-among-commensal-enterobacteriaceae-a-multinational-prospective-cohort-study
#1
Andrew J Stewardson, Jascha Vervoort, Niels Adriaenssens, Samuel Coenen, Maciek Godycki-Cwirko, Anna Kowalczyk, Benedikt Huttner, Christine Lammens, Surbhi Malhotra-Kumar, Herman Goossens, Stephan Harbarth
OBJECTIVES: We quantified the impact of antibiotics prescribed in primary care for urinary tract infections (UTIs) on intestinal colonisation by ciprofloxacin-resistant (CIP-RE) and extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-PE), while accounting for household clustering. METHODS: Prospective cohort study from January 2011 to August 2013 at primary care sites in Belgium, Poland and Switzerland. We recruited outpatients requiring antibiotics for suspected UTIs or asymptomatic bacteriuria (exposed patients), outpatients not requiring antibiotics (non-exposed patients), and 1-3 household contacts for each patient...
January 10, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29327292/alterations-of-growth-rate-and-gene-expression-levels-of-upec-by-antibiotics-at-sub-mic
#2
Defne Gümüş, Fatma Kalaycı-Yüksek, Emre Yörük, Gülşen Uz, Eşref Çelik, Cansu Arslan, Elif Merve Aydın, Cem Canlı, Mine Anğ-Küçüker
The host is the main environment for bacteria, and they also expose to many antibiotics during the treatment of infectious diseases in host body. In this study, it was aimed to investigate possible changes in growth rate and expression levels of three virulence genes (foc/foc, cnf1, and usp) in a uropathogenic E. coli standard strain within the presence of ciprofloxacin, nitrofurantoin, and trimethoprim-sulfamethoxazole. The UPEC C7 strain was grown on tryptic soy broth-TSB (control), TSB + ciprofloxacin, TSB + nitrofurantoin, and TSB + trimethoprim-sulfamethoxazole for determination of both growth rate and gene expression level...
January 11, 2018: Folia Microbiologica
https://www.readbyqxmd.com/read/29324733/antibiotics-dispensed-to-privately-insured-pregnant-women-with-urinary-tract-infections-united-states-2014
#3
Elizabeth C Ailes, April D Summers, Emmy L Tran, Suzanne M Gilboa, Kathryn E Arnold, Dana Meaney-Delman, Jennita Reefhuis
Urinary tract infections (UTIs) occur in about 8% of pregnant women, and untreated UTIs can have serious consequences, including pyelonephritis, preterm labor, low birth weight, and sepsis (1). Pregnant women are typically screened for UTIs during early pregnancy, and those with bacteriuria are treated with antibiotics (1,2). Antibiotic stewardship is critical to improving patient safety and to combating antibiotic resistance. Because of the potential risk for birth defects, including anencephaly, heart defects, and orofacial clefts, associated with use of sulfonamides and nitrofurantoin during pregnancy (3), a 2011 committee opinion from the American College of Obstetricians and Gynecologists (ACOG) recommended that sulfonamides and nitrofurantoin may be prescribed in the first trimester of pregnancy only when other antimicrobial therapies are deemed clinically inappropriate (4)...
January 12, 2018: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29320984/prevalence-and-antibiotic-susceptibility-of-uropathogens-from-cases-of-urinary-tract-infections-uti-in-shashemene-referral-hospital-ethiopia
#4
Wubalem Desta Seifu, Alemayehu Desalegn Gebissa
BACKGROUND: Urinary tract infection (UTI) remains to be one of the most common infectious diseases diagnosed in developing countries. And a widespread use of antibiotics against uropathogens has led to the emergence of antibiotic resistant species. A laboratory based cross-sectional survey was conducted in Shashemene referral hospital to determine the prevalence and antibiotic susceptibility of uropathogens. METHODS: We have collected 384 clean catch mid-stream urine samples from all suspected UTI outpatients using sterile screw capped container...
January 10, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29310252/label-free-photoluminescence-assay-for-nitrofurantoin-detection-in-lake-water-samples-using-adenosine-stabilized-copper-nanoclusters-as-nanoprobes
#5
Yong Wang, Tianxia Chen, Qianfen Zhuang, Yongnian Ni
In this paper, we constructed a novel label-free analytical strategy for highly sensitive and selective detection of nitrofurantoin (NFT) based on adenosine-stabilized copper nanoclusters (CuNCs) as nanoprobes. It was found that NFT caused a rapid decrease in the photoluminescence intensity of CuNCs. The photoluminescence quenching was likely attributed to the inner filter effect between NFT and CuNCs. The CuNCs exhibited a wide linear range of 0.05-4.0μM with the detection limit of 30nM (7.1ngmL-1) for detection of NFT...
March 1, 2018: Talanta
https://www.readbyqxmd.com/read/29305250/diagnosis-and-treatment-of-urinary-tract-infections-across-age-groups
#6
REVIEW
Christine M Chu, Jerry L Lowder
Urinary tract infections (UTI) are the most common outpatient infections, but predicting the probability of UTI through symptoms and test results can be complex. The most diagnostic symptoms of UTI include change in frequency, dysuria, urgency, and presence or absence of vaginal discharge, but UTIs may present differently in older women. Dipstick urinalysis is popular for its availability and usefulness, but results must be interpreted in context of the patient's pretest probability based on symptoms and characteristics...
January 2, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29250044/clonal-diversity-virulence-potential-and-antimicrobial-resistance-of-escherichia-coli-causing-community-acquired-urinary-tract-infection-in-switzerland
#7
Magdalena T Nüesch-Inderbinen, Melinda Baschera, Katrin Zurfluh, Herbert Hächler, Hansjakob Nüesch, Roger Stephan
Objectives: The aim of this study was to assess the clonal structure, virulence potential and antibiotic susceptibility of uropathogenic Escherichia coli (UPEC) isolates causing community acquired urinary tract infection (CAUTI) in unselected primary care patients in Switzerland. Methods: We performed multilocus sequence typing, virulence factor determination, and phenotypic and genotypic antimicrobial resistance testing on 44 non-duplicate UPEC isolates. Results: Twenty-seven different sequence types (STs) were identified...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29246634/genetics-of-bi-component-leukocidin-and-drug-resistance-in-nasal-and-clinical-staphylococcus-aureus-in-lagos-nigeria
#8
Nkechi V Enwuru, Solayide A Adesida, Christian A Enwuru, Beniam Ghebremedhin, Udoma E Mendie, Akitoye O Coker
BACKGROUND: Resistant and virulent Staphylococcus aureus is a global public health challenge. Staphylococcal Bi-component leukotoxins are cytolytic to immune cells and evolve to disarm the innate immunity during infections, hence the severity of the disease. OBJECTIVE: We studied drug resistance profile and the occurrence of bi-component leukocidin in clinical and nasal S. aureus in Lagos, Nigeria. METHOD: Ninety-two S. aureus (70 clinical and 22 nasal) strains were characterized by conventional and molecular methods...
December 12, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29227738/antibiotic-resistance-of-helicobacter-pylori-in-iranian-children-a-systematic-review-and-meta-analysis
#9
Arshid Yousefi-Avarvand, Hamid Vaez, Mohsen Tafaghodi, Amir Hossein Sahebkar, Mohsen Arzanlou, Farzad Khademi
Antibiotic therapy for children infected with Helicobacter pylori is important. However, resistance to antibiotics is one of the main causes of treatment failure. This study was designed to evaluate the prevalence pattern of antibiotic resistance of H. pylori in Iranian children using a systematic review and meta-analysis of literature. A computerized search (until June 10, 2017) using related keywords in the national and international databases was performed. A total of 261 original articles on antibiotic resistance of H...
December 11, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29217096/trend-and-seasonality-of-community-acquired-escherichia-coli-antimicrobial-resistance-and-its-dynamic-relationship-with-antimicrobial-use-assessed-by-arima-models
#10
María Ángeles Asencio Egea, María Huertas Vaquero, Rafael Carranza González, Óscar Herráez Carrera, Olga Redondo González, Ángel Arias Arias
INTRODUCTION: We studied the trend and seasonality of community-acquired Escherichia coli resistance and quantified its correlation with the previous use of certain antibiotics. METHODS: A time series study of resistant community-acquired E. coli isolates and their association with antibiotic use was conducted in a Primary Health Care Area from 2008 to 2012. A Poisson regression model was constructed to estimate the trend and seasonality of E. coli resistance. RESULTS: A significant increasing trend in mean E...
December 4, 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/29210602/assessment-of-the-comparability-of-clsi-eucast-and-stokes-antimicrobial-susceptibility-profiles-for-escherichia-coli-uropathogenic-isolates
#11
C O'Halloran, N Walsh, M C O'Grady, L Barry, C Hooton, G D Corcoran, B Lucey
BACKGROUND: As many clinical laboratories convert between Stokes, Clinical and Laboratory Standards Institute (CLSI) and European Committee for Antimicrobial Susceptibility Testing (EUCAST) methods, the problem of comparing differently derived sets of antimicrobial susceptibility testing (AST) data with each other arises, owing to a scarcity of knowledge of inter-method comparability. The purpose of the current study was to determine the comparability of CLSI, EUCAST and Stokes AST methods for determining susceptibility of uropathogenic Escherichia coli to ampicillin, amoxicillin-clavulanate, trimethoprim, cephradine/cephalexin, ciprofloxacin and nitrofurantoin...
December 6, 2017: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/29208542/antibiotics-susceptibility-of-quinolones-against-salmonella-spp-strains-isolated-and-molecular-sequenced-from-pigs-target-gyra-gene-detection
#12
Guadalupe Patricia Macías Farrera, Roberto Montes de Oca Jiménez, Jorge Varela Guerrero, Esvieta Tenorio Borroto, Fabiola Rivera Ramírez, Humberto Gustavo Monroy Salazar, Gilberto Yong Angel, Abdelfattah Z M Salem
Drug-resistant Salmonella is frequently detected in most parts of the world, and its rate of resistance has increased significantly in recent years. However, this study aimed to evaluate the minimum inhibitory concentration (MIC, determined with the Kirby-Bauer method) of quinolones in 86 Salmonella spp. strains isolated from pigs. Both the inside and outside of the QRDR region of strains were sequenced. The DNA sequence of the QRDR region of Salmonella spp. revealed the mutations S83F, D87N and S83Y. The region outside the QRDR showed a mutation in L582G...
December 2, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29201229/antimicrobial-resistance-and-prevalence-of-cvfb-sek-and-seq-genes-among-staphylococcus-aureus-isolates-from-paediatric-patients-with-bloodstream-infections
#13
Bing-Shao Liang, Yan-Mei Huang, Yin-Shuang Chen, Hui Dong, Jia-Liang Mai, Yong-Qiang Xie, Hua-Min Zhong, Qiu-Lian Deng, Yan Long, Yi-Yu Yang, Si-Tang Gong, Zhen-Wen Zhou
Staphylococcus aureus (S. aureus) is one of the most frequently isolated pathogens in neonatal cases of early and late-onset sepsis. Drug resistance profiles and carriage of toxin genes may affect the treatment and outcome of an infection. The present study aimed to determine the antimicrobial resistance patterns and frequencies of the toxin-associated genes conserved virulence factor B (CvfB), staphylococcal enterotoxin Q (SEQ) and staphylococcal enterotoxin K (SEK) among S. aureus isolates recovered from paediatric patients with bloodstream infections (BSIs) in Guangzhou (China)...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29196069/impact-of-allergy-and-resistance-on-antibiotic-selection-for-recurrent-urinary-tract-infections-in-older-women
#14
Rena D Malik, Yuefeng Rose Wu, Alana L Christie, Feras Alhalabi, Philippe E Zimmern
OBJECTIVES: To review the impact of antibiotic allergy and resistance in older women with recurrent urinary tract infections (RUTIs) as determinants for a suitable oral antibiotic treatment choice. METHODS: A prospectively maintained database of women 65 years old and older with documented RUTIs (≥3 UTI/y) and trigonitis on cystoscopy was reviewed. Demographic data, known drug allergies, renal function, antibiotic susceptibility of most recent urine culture, allergy, or resistance to trimethoprim-sulfamethoxazole (TMP-SMX), fluoroquinolones, and nitrofurantoin were obtained...
November 28, 2017: Urology
https://www.readbyqxmd.com/read/29184992/a-fluorescent-immunochromatographic-strip-test-using-a-quantum-dot-antibody-probe-for-rapid-and-quantitative-detection-of-1-aminohydantoin-in-edible-animal-tissues
#15
Tao Le, Zhihao Zhang, Juan Wu, Haixing Shi, Xudong Cao
A rapid, simple, and sensitive fluorescent immunochromatographic strip test (ICST) based on quantum dots (QDs) has been developed to detect 1-aminohydantoin (AHD), a major metabolite of nitrofurantoin in animal tissues. To achieve this, QD-labeled antibody conjugates, which consist of CdSe/ZnS QDs and monoclonal antibodies, were prepared by an activated ester method. Under optimal conditions, with the nitrophenyl derivative of AHD as the target, the ICST had a linear range from 0.1 to 100 ng/mL, with a correlation coefficient of 0...
November 28, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29169741/utilization-of-antibiotics-in-long-term-care-facilities-in-british-columbia-canada
#16
Fawziah Marra, Mark McCabe, Prateek Sharma, Bin Zhao, Christopher Mill, Victor Leung, Mei Chong, David M Patrick
BACKGROUND: Antibiotic use is highly prevalent in long-term care facilities (LTCFs); a resident's annual exposure to at least 1 course of antibiotic is approximately 50% to 80%. The objective of this study was to understand the extent of antibiotic use in the population of residents in British Columbia's (BC) LTCFs from 2007 to 2014. METHODS: Antibiotic prescription data for LTCF residents was extracted from the central prescription database and linked to the physician billing plan to obtain antibiotic indication...
December 1, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/29168442/seasonality-of-urinary-tract-infections-in-the-united-kingdom-in-different-age-groups-longitudinal-analysis-of-the-health-improvement-network-thin
#17
A Rosello, K B Pouwels, M Domenech DE Cellès, E VAN Kleef, A C Hayward, S Hopkins, J V Robotham, T Smieszek, L Opatowski, S R Deeny
Evidence regarding the seasonality of urinary tract infection (UTI) consultations in primary care is conflicting and methodologically poor. To our knowledge, this is the first study to determine whether this seasonality exists in the UK, identify the peak months and describe seasonality by age. The monthly number of UTI consultations (N = 992 803) and nitrofurantoin and trimethoprim prescriptions (N = 1 719 416) during 2008-2015 was extracted from The Health Improvement Network (THIN), a large nationally representative UK dataset of electronic patient records...
November 23, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/29158722/synthesis-and-investigation-of-antimicrobial-activities-of-nitrofurazone-analogues-containing-hydrazide-hydrazone-moiety
#18
Łukasz Popiołek, Anna Biernasiuk
In this research we synthesized and tested for in vitro antimicrobial activity 21 nitrofurazone analogues. The compounds we obtained were identified on the basis of (1)H NMR and (13)C NMR spectroscopy. The in vitro screening of antimicrobial properties of synthesized compounds revealed a wide spectrum of antimicrobial activity. Compounds 28, 29, 32-43, and 45-48 showed very high bactericidal effect towards Staphylococcus spp. ATTC and Bacillus spp. ATTC (MIC = 0.002-7.81 µg/ml and MBC = 0.002-31.25 µg/ml)...
November 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/29147090/detection-of-antibiotic-resistance-and-resistance-genes-in-enterococci-isolated-from-sucuk-a-traditional-turkish-dry-fermented-sausage
#19
Furkan Demirgül, Yasin Tuncer
The aim of this study was to isolate enterococci in Sucuk, a traditional Turkish dry-fermented sausage and to analyze isolates for their biodiversity, antibiotic resistance patterns and the presence of some antibiotic resistance genes. A total of 60 enterococci strains were isolated from 20 sucuk samples manufactured without using a starter culture and they were identified as E. faecium (73.3%), E. faecalis (11.7%), E. hirae (8.3%), E. durans (3.3%), E. mundtii (1.7%) and E. thailandicus (1.7%). Most of the strains were found resistant to rifampin (51...
2017: Korean Journal for Food Science of Animal Resources
https://www.readbyqxmd.com/read/29137487/emergence-of-fosfomycin-resistance-among-isolates-of-escherichia-coli-harboring-extended-spectrum-and-ampc-%C3%AE-lactamases
#20
Aghil Bahramian, Gita Eslami, Ali Hashemi, Ali Tabibi, Mohsen Heidary
Urinary tract infection (UTI) is a common type of infectious disease globally. The aim of this study was to detect the frequency of fosA3 and fosC2 genes in extended-spectrum β-lactamases (ESBL) and blaDHA, blaCMY-2, and blaCMY-42 genes in AmpC β-lactamases-producing isolates of Escherichia coli. In total, 120 isolates of E. coli were collected from three teaching hospitals between March 2014 and February 2015. Antibiotic susceptibility tests were carried out by disk diffusion method. The presence of blaCMY-2, blaCMY-42, blaDHA, fosA3, and fosC2 genes was detected by polymerase chain reaction (PCR) and sequencing...
November 15, 2017: Acta Microbiologica et Immunologica Hungarica
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