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https://www.readbyqxmd.com/read/28325856/prevalence-of-undiagnosed-asymptomatic-bacteriuria-and-associated-risk-factors-during-pregnancy-a-cross-sectional-study-at-two-tertiary-centres-in-cairo-egypt
#1
Mohamed Abdel-Aziz Elzayat, Ashton Barnett-Vanes, Mohamed Farag Elmorsy Dabour, Feng Cheng
BACKGROUND: The prevalence of asymptomatic bacteriuria (ASB) during pregnancy is poorly understood in Egypt-a country with a high birth rate. OBJECTIVES: To determine the prevalence of ASB among pregnant women booking at El Hussein and Sayed Galal Hospitals in Al-Azhar University in Egypt; and to observe the relationship between ASB prevalence and risk factors such as socioeconomic level and personal hygiene. SETTING: Obstetrics and gynaecology clinics of 2 university hospitals in the capital of Egypt...
March 21, 2017: BMJ Open
https://www.readbyqxmd.com/read/28323886/contribution-of-urinary-tract-infection-to-the-burden-of-febrile-illnesses-in-young-children-in-rural-kenya
#2
Wechuli Geoffrey Masika, Wendy Prudhomme O'Meara, Thomas L Holland, Janice Armstrong
INTRODUCTION: The clinical features of UTI in young children may not localize to the urinary tract and closely resemble other febrile illnesses. In malaria endemic areas, a child presenting with fever is often treated presumptively for malaria without investigation for UTI. Delayed or inadequate treatment of UTI increases the risk of bacteremia and renal scarring in young children and subsequently complications as hypertension and end stage renal disease in adulthood. METHODS: A cross-sectional study was carried out in a hospital in western Kenya...
2017: PloS One
https://www.readbyqxmd.com/read/28323552/helicobacter-pylori-eradication-in-the-swedish-population
#3
Eva Doorakkers, Jesper Lagergren, Vijaya Krishna Gajulapuri, Steven Callens, Lars Engstrand, Nele Brusselaers
OBJECTIVES: Helicobacter pylori is associated with peptic ulcers and gastric cancer and its eradication aims to prevent these conditions. The recommended eradication regimen is triple therapy, consisting of a proton-pump inhibitor in combination with clarithromycin and amoxicillin or metronidazole for 7 days. Yet, other antibiotic regimens are sometimes prescribed. We aimed to assess the use of eradication therapy for H. pylori in the Swedish population during the last decade. MATERIALS AND METHODS: This population-based study used data from the Swedish Prescribed Drug Register...
March 21, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28316632/cost-effectiveness-analysis-of-fosfomycin-for-treatment-of-uncomplicated-urinary-tract-infections-in-ontario
#4
Louise Perrault, Sybil Dahan, Ange Christelle Iliza, Jacques LeLorier, George G Zhanel
Background and Objective. Bacterial resistance to antibiotics traditionally used to treat uncomplicated urinary tract infections (uUTIs) is rising in Canada. We compared the cost-per-patient in Ontario of including fosfomycin (an antibiotic with a low resistance profile) as an option for first-line empirical treatment of uUTIs with current cost of treatment with sulfonamides, fluoroquinolones, and nitrofurantoin. Methods. A decision-tree model was used to perform a cost-minimization analysis. All possible outcomes of a uUTI caused by bacterial species treated with either sulfonamides, fluoroquinolones, nitrofurantoin, or fosfomycin were included...
2017: Canadian Journal of Infectious Diseases & Medical Microbiology
https://www.readbyqxmd.com/read/28306135/how-common-are-pulmonary-and-hepatic-adverse-effects-in-older-adults-prescribed-nitrofurantoin
#5
Karin Claussen, Edward Stocks, Deepa Bhat, Jason Fish, Craig D Rubin
OBJECTIVES: To determine the frequency of serious pulmonary and hepatic adverse events (AEs) in persons aged 65 and older prescribed nitrofurantoin. DESIGN: Retrospective electronic health record (EHR) audit of nitrofurantoin prescriptions and associated AEs. SETTING: Urban academic medical center. PARTICIPANTS: All inpatients and outpatients aged 65 and older prescribed nitrofurantoin from January 1, 2010, to December 31, 2014...
March 17, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28295441/fosfomycin-for-the-treatment-of-cystitis-in-the-abdominal-solid-organ-transplant-population
#6
A A Loethen, L Kerstenetzky, J L Descourouez, G E Leverson, J A Smith, M R Jorgenson
STUDY OBJECTIVES: Evaluate the use of fosfomycin (FOS) at the FDA-approved single-dose regimen as well as off-label multidose regimens for the treatment of cystitis after abdominal solid organ transplant (aSOT). DESIGN: Retrospective study. SETTING: Tertiary academic medical center. PATIENTS: Adult inpatients with history of aSOT receiving FOS between 1/1/2009-4/30/2015 for the treatment of cystitis. MEASUREMENTS AND MAIN RESULTS: Seventy-six courses of FOS were identified in 64 patients...
March 12, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/28288183/maternal-use-of-drug-substrates-of-placental-transporters-and-the-effect-of-transporter-mediated-drug-interactions-on-the-risk-of-congenital-anomalies
#7
Aizati N A Daud, Jorieke E H Bergman, Monika P Oktora, Wilhelmina S Kerstjens-Frederikse, Henk Groen, Jens H Bos, Eelko Hak, Bob Wilffert
BACKGROUND: A number of transporter proteins are expressed in the placenta, and they facilitate the placental transfer of drugs. The inhibition of P-glycoprotein (P-gp) was previously found to be associated with an increase in the risk of congenital anomalies caused by drug substrates of this transporter. We now explore the role of other placental transporter proteins. METHODS: A population-based case-referent study was performed using cases with congenital anomalies (N = 5,131) from EUROCAT Northern Netherlands, a registry of congenital anomalies...
2017: PloS One
https://www.readbyqxmd.com/read/28285420/fosfomycin-and-comparator-activity-against-select-enterobacteriaceae-pseudomonas-and-enterococcus-urinary-tract-infection-isolates-from-the-united-states-in-2012
#8
Tiffany R Keepers, Marcela Gomez, Chris Celeri, Kevin M Krause, Donald Biek, Ian Critchley
INTRODUCTION: Fosfomycin is a broad-spectrum cell wall active agent that inhibits the MurA enzyme involved in peptidoglycan synthesis and is FDA-approved for treatment of uncomplicated urinary tract infections (UTIs) caused by Escherichia coli and Enterococcus faecalis in women. Data regarding the susceptibility of recent UTI isolates to fosfomycin are limited. METHODS: This study compared the fosfomycin susceptibility of 658 US UTI isolates with susceptibility to ciprofloxacin, levofloxacin, nitrofurantoin, and trimethoprim/sulfamethoxazole (SXT)...
March 11, 2017: Infectious Diseases and Therapy
https://www.readbyqxmd.com/read/28276834/drug-induced-liver-injury-due-to-antibiotics
#9
Einar S Björnsson
Drug-induced liver injury (DILI) is an important differential diagnosis in patients with abnormal liver tests and normal hepatobiliary imaging. Of all known liver diseases, the diagnosis of DILI is probably one of the most difficult one to be established. In all major studies on DILI, antibiotics are the most common type of drugs that have been reported. The clinical phenotype of different types of antibiotics associated with liver injury is highly variable. Some widely used antibiotics such as amoxicillin-clavulanate have been shown to have a delayed onset on liver injury and recently cefazolin has been found to lead to liver injury 1-3 weeks after exposure of a single infusion...
February 20, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28274327/antipsychotic-drug-use-associated-with-urinary-tract-infections-in-older-women
#10
Astrid M van Strien, Patrick C Souverein, Carolina Karen J P W Keijsers, Eibert R Heerdink, Hieronymus Jeroen J Derijks, Rob J van Marum
OBJECTIVES: Antipsychotic drugs are frequently prescribed to elderly patients, but they are associated with serious adverse effects. The objective of the current study was to investigate the association between use of antipsychotics by elderly women and the risk of urinary tract infections (UTIs). COHORT STUDY SETTING: Dispensing data were obtained from the PHARMO Database Network for the period 1998-2008. PARTICIPANTS: Ambulatory Dutch women (≥65 years) with current and past use of antipsychotics...
April 2017: Maturitas
https://www.readbyqxmd.com/read/28272142/early-development-identification-of-mode-of-action-and-use-of-dantrolene-sodium-the-role-of-keith-ellis-ph-d
#11
Neil A Pollock, Roslyn G Machon, Henry Rosenberg
Dantrolene-a nitrofurantoin derivative-was developed by Snyder et al. in 1967. After initial discovery of its muscle relaxation potential, investigations in a number of species demonstrated dose-dependent reductions in skeletal muscle tone that were long lasting, relatively nontoxic, and free of adverse effects such as respiratory impairment. Ellis et al. then published a number of papers investigating the means by which dantrolene produced these effects. Using a series of classic physiologic models, Ellis investigated potential sites of action for the new drug, eventually narrowing this down to the intracellular calcium-release mechanism...
March 8, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28271212/influence-of-select-antibiotics-on-vibrio-fischeri-and-desmodesmus-subspicatus-at-%C3%AE-g%C3%A2-l-1-concentrations
#12
E C de Vasconcelos, C R Dalke, C M R de Oliveira
The presence of pharmaceuticals in the aquatic environment is a contemporary reality and it is necessary to understand more about the effects of this presence on organisms. The purpose of this work was to assess the ecotoxicity of antibiotics metronidazole, nitrofurantoin, trimethoprim, and sulphamethoxazole (single and mixture) in Vibrio fischeri and Desmodesmus subspicatus at μg L(-1) concentrations. The evaluation of the toxic effect of the antibiotics on V. fischeri and D. subspicatus was based on fluorescence and bioluminescence tests, respectively, using nominal concentrations...
March 8, 2017: Environmental Management
https://www.readbyqxmd.com/read/28270957/prevalence-of-uropathogen-and-their-antibiotic-resistance-pattern-among-diabetic-patients
#13
Demiss Nigussie, Anteneh Amsalu
OBJECTIVE: Diabetes mellitus (DM) and antibiotic resistance is an emerging public health problem in Ethiopia. Urinary tract infections (UTIs) are common and occasionally life-threatening condition among diabetic patients. Despite, all these problems, antibiotics are prescribed empirically which may adversely affect antibiotic resistance so far. Therefore the aim of this study was to identify the etiologic agents of UTI and their antibiotic resistance pattern among diabetic patients attending diabetic clinic of Hawassa University Referral Hospital...
March 2017: Turkish Journal of Urology
https://www.readbyqxmd.com/read/28255302/urinary-tract-infections-among-hiv-positive-pregnant-women-in-mwanza-city-tanzania-are-high-and-predicted-by-low-cd4-count
#14
Tito Chaula, Jeremiah Seni, Nhandi Ng'walida, Alphaxaid Kajura, Mariam M Mirambo, Rebekah DeVinney, Stephen E Mshana
Introduction. Urinary tract infection (UTI) among pregnant women can lead to adverse maternal and foetal outcomes. UTI has been widely studied in the general obstetric population in Tanzania; the present study evaluated the magnitude, antimicrobial resistance, and predictors of UTI among HIV-positive pregnant women. Methods. Between March and May 2016 midstream urine samples from 234 women attending prevention of mother to child transmission of HIV (PMTCT) clinics were analyzed using standard methods. Data was analyzed by STATA version 11...
2017: International Journal of Microbiology
https://www.readbyqxmd.com/read/28254461/genetic-diversity-of-enterococcus-faecalis-isolated-from-environmental-animal-and-clinical-sources-in-malaysia
#15
Diane S Daniel, Sui M Lee, Han M Gan, Gary A Dykes, Sadequr Rahman
Enterococcus faecalis ranks as one of the leading causes of nosocomial infections. A strong epidemiological link has been reported between E. faecalis inhabiting animals and environmental sources. This study investigates the genetic diversity, antibiotic resistance and virulence determinants in E. faecalis from three sources in Malaysia. A total of 250 E. faecalis isolates were obtained consisting of 120 isolates from farm animals, 100 isolates from water sources and 30 isolates from hospitalized patients. Pulse-field gel electrophoresis-typing yielded 63 pulsotypes, with high diversity observed in all sources (D=≥0...
February 18, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/28247617/-are-there-alternatives-to-antimicrobial-therapy-and-prophylaxis-of-uncomplicated-urinary-tract-infections
#16
K G Naber, J F Alidjanov
The acute uncomplicated cystitis in women is one of the most frequently diagnosed bacterial infection. A clinically symptomatic urinary tract infection must be differentiated from the asymptomatic bacteriuria, which is not considered an infection but rather a colonization which should not be treated. For the antimicrobial therapy according to the European guidelines the old oral antibiotics (fosfomycin trometamol, nitrofurantoin, pivmecillinam) should be prescribed, against which E. coli is still susceptible in over 90%...
August 2016: Urologii︠a︡
https://www.readbyqxmd.com/read/28246454/molecular-identification-and-histopathological-study-of-natural-streptococcus-agalactiae-infection-in-hybrid-tilapia-oreochromis-niloticus
#17
A A Laith, Mohd Azmi Ambak, Marina Hassan, Shahreza Md Sheriff, Musa Nadirah, Ahmad Shuhaimi Draman, Wahidah Wahab, Wan Nurhafizah Wan Ibrahim, Alia Syafiqah Aznan, Amina Jabar, Musa Najiah
AIM: The main objective of this study was to emphasize on histopathological examinations and molecular identification of Streptococcus agalactiae isolated from natural infections in hybrid tilapia (Oreochromis niloticus) in Temerloh Pahang, Malaysia, as well as to determine the susceptibility of the pathogen strains to various currently available antimicrobial agents. MATERIALS AND METHODS: The diseased fishes were observed for variable clinical signs including fin hemorrhages, alterations in behavior associated with erratic swimming, exophthalmia, and mortality...
January 2017: Veterinary World
https://www.readbyqxmd.com/read/28207423/an-unusual-case-of-nitrofurantoin-associated-hepatotoxicity
#18
Poornima Ramadas, Prathik Krishnan, Vincent Frechette
No abstract text is available yet for this article.
February 15, 2017: American Journal of Therapeutics
https://www.readbyqxmd.com/read/28193660/antimicrobial-resistance-of-escherichia-coli-urinary-isolates-in-the-veterans-affairs-healthcare-system
#19
Haley J Morrill, Jacob B Morton, Aisling R Caffrey, Lan Jiang, David Dosa, Leonard A Mermel, Kerry L LaPlante
We reviewed almost 300,000 clinical E. coli urine isolates (2009-2013) from 127 facilities to assess antibiotic resistance among Veterans Affairs healthcare system patients using Clinical Laboratory Standards Institute and Centers for Disease Control and Prevention National Healthcare Safety Network definitions/guidance. Resistance to fluoroquinolones and trimethoprim/sulfamethoxazole approached 30%. Resistance to nitrofurantoin, anti-pseudomonal penicillin/beta-lactamase inhibitors, and carbapenems remained less than 10%...
February 13, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28187754/extended-spectrum-beta-lactamase-producing-organisms-causing-urinary-tract-infections-in-sri-lanka-and-their-antibiotic-susceptibility-pattern-a-hospital-based-cross-sectional-study
#20
M M P S C Fernando, W A N V Luke, J K N D Miththinda, R D S S Wickramasinghe, B S Sebastiampillai, M P M L Gunathilake, F H D S Silva, R Premaratna
BACKGROUND: Extended Spectrum Beta- Lactamase producing organisms causing urinary tract infections (ESBL-UTI) are increasing in incidence and pose a major burden to health care. While ESBL producing Klebsiella species seem to account for most nosocomial outbreaks, ESBL-producing E. coli have been isolated from both hospitalized and non-hospitalized patients. Although 95-100% ESBL organisms are still considered sensitive to meropenem, rapid emergence of carbapenem resistance has been documented in many countries...
February 10, 2017: BMC Infectious Diseases
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