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https://www.readbyqxmd.com/read/28631909/-characterization-of-microbial-flora-in-patients-suspected-of-having-urogenital-tuberculosis
#1
A G Cherednichenko, E V Kulchavenya
INTRODUCTION: In the structure of tuberculosis morbidity, urogenital tuberculosis (UGT) ranks second or third only to pulmonary tuberculosis. Every fourth patient has the stage of cavern formation at first presentation. Seventy five percent of nephrotuberculosis cases co-occur with nonspecific pyelonephritis, which excludes "sterile pyuria". We aimed to determine the microbial spectrum of urine and gonadal appendages in patients with suspected UGT and to investigate the susceptibility of the isolated microorganisms to the main antibacterial drugs...
June 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/28615465/emergency-department-urinary-antibiograms-differ-by-specific-patient-groups
#2
S Jorgensen, M Zurayk, S Yeung, J Terry, M Dunn, P Nieberg, A Wong-Beringer
Background: Patients presenting to the ED represent a heterogeneous population comprised of all ages, from the community and skilled-nursing facilities (SNF), and at varying risk for resistant pathogens. The aim of this study was to compare patient group-specific urinary antibiograms in ED.Methods: Adults presented to ED with an ICD 9/10 UTI diagnosis during 7/15 - 6/16 were randomly selected (n=500) to extract relevant demographic, laboratory, and clinical data from the medical record. Urinary E. coli antibiograms were compared between: institutional vs...
June 14, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28604274/routine-prophylactic-antimicrobial-use-is-associated-with-increased-phenotypic-and-genotypic-resistance-in-commensal-escherichia-coli-isolates-recovered-from-healthy-fattening-pigs-on-farms-in-thailand
#3
Kittitat Lugsomya, Thanitta Chatsuwan, Waree Niyomtham, Padet Tummaruk, David J Hampson, Nuvee Prapasarakul
This study examined antimicrobial resistance (AMR) profiles in commensal Escherichia coli derived from healthy fattening pigs in Thai farms that used prophylactic antimicrobials (in-feed tiamulin fumarate and amoxicillin) [PAs], therapeutic antimicrobials (injectable enrofloxacin or gentamicin) [TAs], or no antimicrobials [NAs]. Commensal E. coli were used as a proxy for overall AMR on the farms. There was a high level of multidrug resistance in all three categories of farm, with isolates showing resistance to β-lactams (amoxicillin, ampicillin, and piperacillin) and tetracyclines (tetracycline), and commonly possessing tetA, blaTEM, and plasmid replicons FIB and F...
June 12, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/28600080/novel-pyridyl-nitrofuranyl-isoxazolines-show-antibacterial-activity-against-multiple-drug-resistant-staphylococcus-species
#4
Pietro Picconi, Priya Prabaharan, Jennifer L Auer, Stephanie Sandiford, Francesco Cascio, Madiha Chowdhury, Charlotte Hind, Matthew E Wand, J Mark Sutton, Khondaker M Rahman
A novel series of pyridyl nitrofuranyl isoxazolines were synthesized and evaluated for their antibacterial activity against multiple drug resistant (MDR) Staphylococcus strains. Compounds with piperazine linker between the pyridyl group and isoxazoline ring showed better activity when compared to compounds without the piperazine linker. 3-Pyridyl nitrofuranyl isoxazoline with a piperazine linker was found to be more active than corresponding 2-and 4-pyridyl analogues with MICs in the range of 4-32µg/mL against MDR Staphylococcus strains...
May 19, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28571186/clinical-and-laboratory-profile-of-urinary-tract-infections-in-type-2-diabetics-aged-over-60-years
#5
Sadhna Sharma, Biju Govind, Sujeet Kumar Naidu, Srinivas Kinjarapu, Mohammed Rasool
INTRODUCTION: Urinary tract infections are frequently encountered among diabetic patients and the incidence rate increases with age. There have been growing research to identify the clinical profile of urinary tract infections in diabetic patients. However, such studies on elderly patients are rare. AIM: To determine the risk factors, clinical/laboratory profiles, causative organisms and antimicrobial susceptibilities in type 2 diabetics aged over 60 years. MATERIALS AND METHODS: This prospective single centre study was conducted at NRI Medical College and General Hospital, Guntur, India, between November 2012 and November 2014...
April 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28557789/stability-of-alprazolam-atropine-sulfate-glutamine-levofloxacin-metoprolol-tartrate-nitrofurantoin-ondansetron-hydrochloride-oxandrolone-pregabaline-and-riboflavin-in-syrspend-sf-ph4-oral-suspensions
#6
Anderson O Ferreira, Hudson C Polonini, Sharlene Loures da Silva, Victor Augusto Cerqueira de Melo, Laura de Andrade, Marcos Antônio Fernandes Brandão
The objective of this study was to evaluate the stability of 10 commonly used active pharmaceutical ingredients compounded in oral suspensions using an internationally used suspending vehicle (SyrSpend SF PH4): alprazolam 1.0 mg/mL, atropine sulfate 0.1 mg/mL, glutamine 250.0 mg/mL, levofloxacin 50.0 mg/mL, metoprolol tartrate 10.0 mg/mL, nitrofurantoin 2.0 mg/mL, ondansetron hydrochloride 0.8 mg/mL, oxandrolone 3.0 mg/mL, pregabaline 20.0 mg/mL, riboflavin 10.0 mg/mL. All suspensions were stored at both controlled refrigeration (2°C to 8°C) and controlled room temperature (20°C to 25°C)...
May 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/28546984/the-comparison-of-printed-resources-bacterial-contamination-in-libraries-of-al-zahra-hospital-and-sciences-faculty-of-isfahan-university-and-the-determination-of-their-antibiotic-sensitivity-pattern
#7
Hosein Rafiei, Mostafa Chadeganipour, Rezvan Ojaghi, Mohammad Reza Maracy, Rasool Nouri
INTRODUCTION: During the library loan process, the printed resources can be a carrier of pathogenic bacteria. In this study, it was tried to compare the Bacterial Contamination Rates and their antibiotic sensitivity pattern in printed resources of a hospital and a non-hospital library. METHODS: This is a cross-sectional study. Returning books from the Al-Zahra hospital library and library of Sciences faculty of Isfahan University provides the research community...
2017: Journal of Education and Health Promotion
https://www.readbyqxmd.com/read/28536210/systemic-inflammatory-response-syndrome-sirs-and-a-left-bundle-branch-block-lbbb-due-to-nitrofurantoin
#8
Susheer Dilbagh Gandotra, Mariola A Smotrys, Darshan B Patel, Akash Chadha
We present a case of a 74-year-old woman, who was on nitrofurantoin treatment for urinary tract infection (UTI), with fever and chills 7 hours after taking nitrofurantoin. She was hospitalised and evaluated for worsening UTI and sepsis. Initially, it appeared to be secondary to post-UTI sepsis because of possible resistant infection or conditions like pulmonary embolism or acute hepatitis. The patient also developed systemic inflammatory response syndrome, left bundle branch block (LBBB), thrombocytopaenia and transaminitis...
May 22, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28513644/light-induced-cytotoxicity-of-nitrofurantoin-toward-murine-melanoma
#9
Lucimara P Ferreira, Gustavo G Parra, Débora C K Codognato, André M Amado, Roberto S da Silva
The cytotoxicity of nitrofurantoin (NFT) in the dark and after light exposure (UVA irradiation, λ = 385 nm) was evaluated in murine melanoma B16F10 cells. NFT induces both cell proliferation and inhibition of cell viability. The dominance of one or the other effect depends on the drug concentration, incubation time (tinc) and irradiation dose. The uptake of NFT in these cells, as well as its photocytotoxicity, reaches saturation after 24 hours of incubation. The mechanism of cell death in the dark is associated with the enzymatic release of nitric oxide (NO)...
May 17, 2017: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/28503324/a-5-day-antibiotic-course-for-treatment-of-intermittent-catheter-associated-urinary-tract-infection-in-patients-with-spinal-cord-injury
#10
Jean-Gabriel Previnaire, Morgane Le Berre, Elisabeth Hode, Vincent Dacquet, Hemanou Bordji, Pierre Denys, Jean-Marc Soler
INTRODUCTION: This was a retrospective monocentric study conducted at Centre Calvé, France, with the objective of evaluating the effectiveness of a 5-day course of antibiotics for symptomatic (mild urinary tract infection, UTI) or asymptomatic (aBact) bacteriuria in patients with spinal cord injury on intermittent catheterization. CASE PRESENTATION: This study was conducted from May 2013 to September 2016. Antibiotic selection always followed culture collection and analysis of antibiograms...
2017: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/28497052/etiological-and-resistance-profile-of-bacteria-involved-in-urinary-tract-infections-in-young-children
#11
Antonio Sorlózano-Puerto, José María Gómez-Luque, Juan de Dios Luna-Del-Castillo, José María Navarro-Marí, José Gutiérrez-Fernández
Background. The objective of this study was to identify the bacteria most frequently responsible for urinary tract infection (UTI) in the population of under-2-year-olds in our geographic area and to evaluate the activity of antibiotics widely used for UTI treatment during a 4-year study period. Materials and Methods. A retrospective analysis was conducted of data on the identification and susceptibility of microorganisms isolated in urine samples from children under 2 years of age. Results. A total of 1,045 uropathogens were isolated...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28486532/antibiotic-resistance-rates-and-physician-antibiotic-prescription-patterns-of-uncomplicated-urinary-tract-infections-in-southern-chinese-primary-care
#12
Carmen Ka Man Wong, Kenny Kung, Philip Lung Wai Au-Doung, Margaret Ip, Nelson Lee, Alice Fung, Samuel Yeung Shan Wong
Uncomplicated urinary tract infections (UTI) are common in primary care. Whilst primary care physicians are called to be antimicrobial stewards, there is limited primary care antibiotic resistance surveillance and physician antibiotic prescription data available in southern Chinese primary care. The study aimed to investigate the antibiotic resistance rate and antibiotic prescription patterns in female patients with uncomplicated UTI. Factors associated with antibiotic resistance and prescription was explored...
2017: PloS One
https://www.readbyqxmd.com/read/28484209/synergic-bactericidal-effects-of-reduced-graphene-oxide-and-silver-nanoparticles-against-gram-positive-and-gram-negative-bacteria
#13
Karthika Prasad, G S Lekshmi, Kola Ostrikov, Vanessa Lussini, James Blinco, Mandhakini Mohandas, Krasimir Vasilev, Steven Bottle, Kateryna Bazaka, Kostya Ostrikov
Reduced graphene oxide (rGO) is a promising antibacterial material, the efficacy of which can be further enhanced by the addition of silver nanoparticles (nAg). In this study, the mechanisms of antibacterial activity of rGO-nAg nanocomposite against several important human pathogenic multi-drug resistant bacteria, namely Gram-positive coccal Staphylococcus aureus and Gram-negative rod-shaped Escherichia coli and Proteus mirabilis are investigated. At the same concentration (100 µg/ml), rGO-nAg nanocomposite was significantly more effective against all three pathogens than either rGO or nAg...
May 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28483600/phenotypic-and-genotypic-study-of-biofilm-formation-in-enterococci-isolated-from-urinary-tract-infections
#14
F Fallah, M Yousefi, M R Pourmand, A Hashemi, A Nazari Alam, D Afshar
BACKGROUND: Urinary tract infection (UTI) is one of the most frequent types of nosocomial and community acquired infections in humans. Management of multidrug-resistant Enterococci UTI due to the limited therapeutic options is a great challenge for physicians and clinical microbiologists. The role of bacterial biofilms in recurrent urinary tract infections and antimicrobial resistance has great importance for public health. The aim of this study was to investigate the antibiotic susceptibility pattern as well as the phenotypic and genotypic biofilm formation ability of Enterococci isolates from patients with UTI...
July 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28479906/factors-associated-with-community-acquired-urinary-tract-infections-among-adults-attending-assessment-centre-mulago-hospital-uganda
#15
Deus Kabugo, Samuel Kizito, Dave Dhara Ashok, Kiwanuka Alexander Graham, Ronald Nabimba, Sandra Namunana, M Richard Kabaka, Beatrice Achan, Florence C Najjuka
BACKGROUND: Urinary tract infections (UTI) are a common medical problem affecting the general population and thus commonly encountered in medical practice, with the global burden of UTIs at about 150 million people. Because uropathogens largely originate from colonic flora, they are easy to predict, and this is the rationale for empirical treatment in Community Acquired-UTI (CA-UTIs). With the increasing prevalence of drug-resistant bacteria among adults with CA-UTI in Uganda, it is no longer adequate to manage CA-UTIs on empiric regimen without revising the susceptibility patterns of common CA-UTI causative agents...
December 2016: African Health Sciences
https://www.readbyqxmd.com/read/28474416/a-lanthanide-mof-thin-film-fixed-with-co3-o4-nano-anchors-as-a-highly-efficient-luminescent-sensor-for-nitrofuran-antibiotics
#16
Feng Zhang, Hua Yao, Tianshu Chu, Gaowei Zhang, Yi Wang, Yangyi Yang
Nitrofurans are a group of widely used veterinary antibiotics, which have been banned due to antibiotics pollution. Development of a rapid and effective method for the detection of nitrofuran antibiotics (NFAs) is an important challenge. Herein, we designed a chemical sensor based on a thin-film composed of the lanthanide metal-organic framework (Ln-MOF) {[Eu2 (BCA)3 (H2 O)(DMF)3 ]⋅0.5DMF⋅H2 O}n (Eu-BCA, in which BCA is 2,2'-biquinoline-4,4'-dicarboxylate) coated on a cost-effective stainless steel wire mesh (SSWM) by Co3 O4 nano-anchor fixation method...
May 4, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28455578/-epidemiology-diagnostics-therapy-prevention-and-management-of-uncomplicated-bacterial-outpatient-acquired-urinary-tract-infections-in-adult-patients-update-2017-of-the-interdisciplinary-awmf-s3-guideline
#17
REVIEW
J Kranz, S Schmidt, C Lebert, L Schneidewind, W Vahlensieck, U Sester, R Fünfstück, S Helbig, W Hofmann, E Hummers, M Kunze, E Kniehl, K Naber, F Mandraka, B Mündner-Hensen, G Schmiemann, F M E Wagenlehner
BACKGROUND: Update of the 2010 published evidence-based S3 guideline on epidemiology, diagnostics, therapy and management of uncomplicated, bacterial, outpatient-acquired urinary tract infections in adult patients. The guideline contains current evidence for the rational use of antimicrobial substances, avoidance of inappropriate use of certain antibiotic classes and development of resistance. METHODOLOGY: The update was created under the leadership of the German Association of Urology (DGU)...
April 28, 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/28451747/-community-acquired-urinary-tract-infections-association-with-risk-factors-changes-in-causative-organisms-and-resistance-over-time
#18
B Ubrig, M Böhme, A Merklinghaus, F Wagenlehner
BACKGROUND: Published studies on community-acquired urinary tract infections (UTI) often do not link microbiological findings with clinical risk factors and patient data. MATERIALS AND METHODS: We retrospectively correlated clinical findings of all patients with UTI of a urological outpatient clinic with the respective microbiological analysis of their urine samples over 2 periods of time: (A: 2005-2006 and B: 2011-2012). Patients were stratified to the following risk groups: uncomplicated cystitis, diabetes mellitus type 2, nursing home resident, prostatitis/epidydimitis, permanent catheter...
April 27, 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/28446177/the-susceptibility-to-fosfomycin-of-gram-negative-bacteria-isolates-from-urinary-tract-infection-in-the-czech-republic-data-from-a-unicentric-study
#19
Miroslav Fajfr, Miroslav Louda, Pavla Paterová, Lenka Ryšková, Jaroslav Pacovský, Josef Košina, Helena Žemličková, Miloš Broďák
BACKGROUND: Against a background of rapid increase of β-lactamase-producing or multi-resistant pathogenic bacteria and the resulting lack of effective antibiotic treatment, some older antibiotics have been tested for new therapeutic uses. One of these is fosfomycin, to which according to studies these resistant bacteria are very sensitive. Our study was designed because there is no data on the fosfomycin susceptibility rate in the Czech Republic. METHOD: In this study from January 2013 to June 2014 3295 unique isolates of Gram-negative bacteria which had caused urinary tract infections were examined...
April 26, 2017: BMC Urology
https://www.readbyqxmd.com/read/28445079/multiple-antimicrobial-resistance-and-novel-point-mutation-in-fluoroquinolone-resistant-escherichia-coli-isolates-from-mangalore-india
#20
Santhosh Kogaluru Shivakumaraswamy, Deekshit Vijaya Kumar, Venugopal Moleyuru Nagarajappa, Iddya Karunasagar, Indrani Karunasagar
Fluoroquinolone resistance in bacteria is usually associated with mutations in the topoisomerase regions. We report a novel point mutation in fluoroquinolone-resistant Escherichia coli strains. E. coli isolated from the environment in and around Mangalore, India, were examined for their antimicrobial resistance profile to 12 antibiotics and for the antibiotic resistance genes by polymerase chain reaction. Of the 67 E. coli isolated, 24 (35.8%) were sensitive to all antibiotics and 43 (64.2%) showed resistance to at least one of the 12 antibiotics used in the study...
April 26, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
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