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https://www.readbyqxmd.com/read/28639475/ecological-correlates-of-multiple-sexual-partnerships-among-adolescents-and-young-adults-in-urban-cape-town-a-cumulative-risk-factor-approach
#1
Evans Muchiri, Clifford Odimegwu, Pamela Banda, Lorreta Ntoimo, Sunday Adedini
Studies in South Africa have reported unsafe levels of risky sexual behvaiours among adolescents and young adults, with the country reporting the highest burden of HIV/AIDS globally, as well as a high rate of teenage pregnancy. While determinants of risky sexual behaviours have been investigated for factors occurring at the individual and household levels, not fully explored in the literature is the effect of community level factors. Furthermore, it is unclear whether risk factors occurring within the ecology of adolescents and young adults act cumulatively to influence their sexual practices...
June 22, 2017: African Journal of AIDS Research: AJAR
https://www.readbyqxmd.com/read/28632445/critique-and-contribute-a-practice-based-framework-for-improving-critical-data-studies-and-data-science
#2
Gina Neff, Anissa Tanweer, Brittany Fiore-Gartland, Laura Osburn
What would data science look like if its key critics were engaged to help improve it, and how might critiques of data science improve with an approach that considers the day-to-day practices of data science? This article argues for scholars to bridge the conversations that seek to critique data science and those that seek to advance data science practice to identify and create the social and organizational arrangements necessary for a more ethical data science. We summarize four critiques that are commonly made in critical data studies: data are inherently interpretive, data are inextricable from context, data are mediated through the sociomaterial arrangements that produce them, and data serve as a medium for the negotiation and communication of values...
June 2017: Big Data
https://www.readbyqxmd.com/read/28610529/regulation-is-not-the-only-way
#3
Richard Hatchett
Healthcare regulation is about public protection. Whether the public is at increased risk from a nurse practitioner, and whether that risk can be addressed within the current regulatory framework, has been grappled with by the profession, regulators and employers for years.
June 14, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28592181/grappling-with-the-future-the-messiness-of-pilot-implementation-in-information-systems-design
#4
Morten Hertzum, Maria Ie Manikas, Arnvør Á Torkilsheyggi
Pilot implementation is a method for avoiding unintended consequences of healthcare information systems. This study investigates how learning from pilot implementations is situated, messy, and therefore difficult. We analyze two pilot implementations by means of observation and interviews. In the first pilot implementation, the involved porters saw their improved overview of pending patient transports as an opportunity for more self-organization, but this opportunity hinged on the unclear prospects of extending the system with functionality for the porters to reply to transport requests...
June 1, 2017: Health Informatics Journal
https://www.readbyqxmd.com/read/28582994/which-primary-care-model-a-qualitative-analysis-of-ward-based-outreach-teams-in-south-africa
#5
Tessa S Marcus, Jannie Hugo, Champak C Jinabhai
Globally, models of extending universal health coverage through primary care are influenced by country-specific systems of health care and disease management. In 2015 a rapid assessment of the ward-based outreach component of primary care reengineering was commissioned to understand implementation and rollout challenges. AIM: This article aims to describe middle- and lower-level managers' understanding of ward-based outreach teams (WBOTs) and the problems of authority, jurisdiction and practical functioning that arise from the way the model is constructed and has been operationalised...
May 31, 2017: African Journal of Primary Health Care & Family Medicine
https://www.readbyqxmd.com/read/28561700/value-based-medicine-and-integration-of-tumor-biology
#6
Gabriel A Brooks, Linda D Bosserman, Isa Mambetsariev, Ravi Salgia
Clinical oncology is in the midst of a genomic revolution, as molecular insights redefine our understanding of cancer biology. Greater awareness of the distinct aberrations that drive carcinogenesis is also contributing to a growing armamentarium of genomically targeted therapies. Although much work remains to better understand how to combine and sequence these therapies, improved outcomes for patients are becoming manifest. As we welcome this genomic revolution in cancer care, oncologists also must grapple with a number of practical problems...
2017: American Society of Clinical Oncology Educational Book
https://www.readbyqxmd.com/read/28553995/mapping-regulatory-models-for-medicinal-cannabis-a-matrix-of-options
#7
Vendula Belackova, Marian Shanahan, Alison Ritter
Objective The aim of the present study was to develop a framework for assessing regulatory options for medicinal cannabis in Australia.Methods International regulatory regimes for medicinal cannabis were reviewed with a qualitative policy analysis approach and key policy features were synthesised, leading to a conceptual framework that facilitates decision making across multiple dimensions.Results Two central organising dimensions of medicinal cannabis regulation were identified: cannabis supply and patient authorisation (including patient access)...
May 30, 2017: Australian Health Review: a Publication of the Australian Hospital Association
https://www.readbyqxmd.com/read/28512758/reporting-practices-for-unsolicited-and-secondary-findings-from-next-generation-sequencing-technologies-perspectives-of-laboratory-personnel
#8
Danya F Vears, Karine Sénécal, Pascal Borry
While next-generation sequencing (NGS) has enormous potential to identify genetic causes of disease, the nature of the technology means that it can also identify additional information about the individual receiving sequencing that is unrelated to the original rationale for testing. Reporting these unsolicited findings (UF) to clinicians, and subsequently to patients, could lead to potentially lifesaving interventions. Most international guidelines provide limited specific recommendations as to whether these UF should be reported...
May 16, 2017: Human Mutation
https://www.readbyqxmd.com/read/28509570/learners-perspectives-on-the-provision-of-condoms-in-south-african-public-schools
#9
W E de Bruin, S Panday-Soobrayan
A stubborn health challenge for learners in South African public schools concerns sexual and reproductive health and rights (SRHR). In 2015, the Department of Basic Education (DBE) proposed the provision of condoms and SRHR-services to learners in schools. This study aimed to contribute to the finalisation and implementation of DBE's policy by exploring learners' perspectives on the provision of condoms and SRHR-services in schools. Sixteen focus group discussions were conducted with learners (n = 116) from 33 public schools, to assess their attitudes, social influences, and needs and desires regarding condom provision and SRHR-services in schools...
May 16, 2017: AIDS Care
https://www.readbyqxmd.com/read/28473627/everything-in-moderation-even-hype-learning-from-vaccine-controversies-to-strike-a-balance-with-crispr
#10
Shawna Benston
The ease and applicability of CRISPR/Cas9--a new and precise gene editing and reproductive technology--have garnered hype and heightened concern about its potential 'unprecedented and horrific consequences' and have led many scientific leaders to call for a moratorium on its research and use. CRISPR appears distinctly more controversial than previous technological innovations (genetic or otherwise), with a greater reach and speed of human treatment and enhancement; however, we have seen similarly inflated hopes and fears in response to other medical innovations for well over a century...
May 4, 2017: Journal of Medical Ethics
https://www.readbyqxmd.com/read/28464878/-it-s-a-waiting-game-a-qualitative-study-of-the-experience-of-carers-of-patients-who-require-an-alternate-level-of-care
#11
Kerry Kuluski, Jennifer Im, Mary McGeown
BACKGROUND: Delayed hospital discharge (also known as Alternate Level of Care or ALC) is a global health care quality issue with negative implications for people (e.g., functional decline) and the health care system (e.g., costly interruptions in hospital flow and procedures). ALC disproportionately impacts people with cognitive impairment, and insight into the needs and experiences of this specific sub population and their carers is lacking. The purpose of this study was to understand the hospital experience of carers (e...
May 2, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28460610/a-perspective-on-water-site-prediction-methods-for-structure-based-drug-design
#12
Alan P Graves, Ian D Wall, Colin M Edge, James M Woolven, Guanglei Cui, Armelle Le Gall, Xuan Hong, Kaushik Raha, Eric S Manas
Over the last decade a number of computational methods have been developed, which attempt to evaluate the thermodynamic properties of individual water molecules at the solute-solvent interface, in order to assess contributions to protein-ligand binding. In some cases these tools tell us what we already know, e.g. that hydrophobic pockets prefer lipophilic substituents, and in other cases the methods only seem to add clarity when retrospectively applied. Hence we have grappled with how to utilize such approaches to understand non-intuitive results and to generate chemistry ideas that otherwise would not have been developed...
April 26, 2017: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/28453975/synaptic-plasticity-in-dendrites-complications-and-coping-strategies
#13
REVIEW
Bartlett W Mel, Jackie Schiller, Panayiota Poirazi
The elaborate morphology, nonlinear membrane mechanisms and spatiotemporally varying synaptic activation patterns of dendrites complicate the expression, compartmentalization and modulation of synaptic plasticity. To grapple with this complexity, we start with the observation that neurons in different brain areas face markedly different learning problems, and dendrites of different neuron types contribute to the cell's input-output function in markedly different ways. By committing to specific assumptions regarding a neuron's learning problem and its input-output function, specific inferences can be drawn regarding the synaptic plasticity mechanisms and outcomes that we 'ought' to expect for that neuron...
April 25, 2017: Current Opinion in Neurobiology
https://www.readbyqxmd.com/read/28449047/what-s-buzzing-on-your-feed-health-authorities-use-of-facebook-to-combat-zika-in-singapore
#14
Santosh Vijaykumar, Rianne Wally Meurzec, Karthikayen Jayasundar, Claudia Pagliari, Yohan Fernandopulle
In 2016, Singapore grappled with one of the largest Zika outbreaks in Southeast Asia. This study examines the use of Facebook for Zika-related outreach by the Ministry of Health (MOH) and the National Environmental Agency (NEA) from March 1, 2015, to September 1, 2016, and public response to this effort. Despite nearly equivalent outreach, MOH's Facebook posts received more likes (µ = 3.49) and shares (µ = 30.11), whereas NEA's posts received more comments (µ = 4.55), with NEA posting mostly on prevention (N = 30) and MOH on situational updates (N = 24)...
April 25, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/28403243/within-season-variability-of-fighting-behaviour-in-an-australian-alpine-grasshopper
#15
Giselle Muschett, Kate D L Umbers, Marie E Herberstein
Throughout the breeding season, changing environmental and biological conditions can lead to variation in the reproductive landscape of many species. In alpine environments temperature is a key driver of behaviour for small ectotherms such as insects, but variable biotic factors such as mate quality and availability can also influence behaviour. Kosicuscola tristis is a small semelparous grasshopper of the Australian alpine region. In a rare behaviour among grasshoppers, K. tristis males engage in vigorous fights over access to females, involving mandible displays, kicking, biting and grappling...
2017: PloS One
https://www.readbyqxmd.com/read/28402827/structural-racism-and-health-inequities-in-the-usa-evidence-and-interventions
#16
REVIEW
Zinzi D Bailey, Nancy Krieger, Madina Agénor, Jasmine Graves, Natalia Linos, Mary T Bassett
Despite growing interest in understanding how social factors drive poor health outcomes, many academics, policy makers, scientists, elected officials, journalists, and others responsible for defining and responding to the public discourse remain reluctant to identify racism as a root cause of racial health inequities. In this conceptual report, the third in a Series on equity and equality in health in the USA, we use a contemporary and historical perspective to discuss research and interventions that grapple with the implications of what is known as structural racism on population health and health inequities...
April 8, 2017: Lancet
https://www.readbyqxmd.com/read/28399003/a-comprehensive-response-the-role-of-nonstate-actors-in-the-global-plan
#17
REVIEW
Robert J Vitillo, Francesca Merico, Anna S Levine, Taylor Buonocore
Nonstate actors-especially faith-based organizations, other nongovernmental organizations, groups of people living with HIV and AIDS, and private sector organizations-have been deeply committed to supporting governments reach the goals of the Global Plan Towards the Elimination of New HIV Infections Among Children by 2015 and Keeping Their Mothers Alive (Global Plan). This article highlights the role and contributions of select faith-based organizations and some private sector and philanthropic partners, as well as the work of other organizations...
May 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28379862/vermont-hub-and-spoke-model-of-care-for-opioid-use-disorder-development-implementation-and-impact
#18
John R Brooklyn, Stacey C Sigmon
BACKGROUND: Opioid use disorders (OUDs) are reaching epidemic proportions in the United States, and many geographic areas struggle with a persistent shortage in availability of opioid agonist treatment. Over the past 5 years, Vermont addiction medicine physicians and public health leaders have responded to these challenges by developing an integrated hub-and-spoke opioid treatment network. METHODS: In the present report, we review the development, implementation, and impact of this novel hub-and-spoke model for expanding OUD treatment in Vermont...
April 4, 2017: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/28372961/big-data-and-machine-learning-strategies-for-driving-this-bus-a-summary-of-the-2016-intersociety-summer-conference
#19
Jonathan B Kruskal, Seth Berkowitz, J Raymond Geis, Woojin Kim, Paul Nagy, Keith Dreyer
The 38th radiology Intersociety Committee reviewed the current state and future direction of clinical data science and its application to radiology practice. The assembled participants discussed the need to use current technology to better generate and demonstrate radiologists' value for our patients and referring providers. The attendants grappled with the potentially disruptive applications of machine learning to image analysis. Although the prospect of algorithms' interpreting images automatically initially shakes the core of the radiology profession, the group emerged with tremendous optimism about the future of radiology...
March 29, 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/28369460/from-reads-to-operational-taxonomic-units-an-ensemble-processing-pipeline-for-miseq-amplicon-sequencing-data
#20
Mohamed Mysara, Mercy Njima, Natalie Leys, Jeroen Raes, Pieter Monsieurs
The development of high-throughput sequencing technologies has provided microbial ecologists with an efficient approach to assess bacterial diversity at an unseen depth, particularly with the recent advances in the Illumina MiSeq sequencing platform. However, analyzing such high-throughput data is posing important computational challenges, requiring specialized bioinformatics solutions at different stages during the processing pipeline, such as assembly of paired-end reads, chimera removal, correction of sequencing errors, and clustering of those sequences into Operational Taxonomic Units (OTUs)...
February 1, 2017: GigaScience
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