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Electrochemotherapy

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https://www.readbyqxmd.com/read/29673795/electrochemotherapy-for-breast-cancer-results-from-the-inspect-database
#1
Louise Wichmann Matthiessen, Mohammed Keshtgar, Pietro Curatolo, Christian Kunte, Eva-Maria Grischke, Joy Odili, Tobian Muir, David Mowatt, James P Clover, Se Hwang Liew, Karin Dahlstroem, Jackie Newby, Valerie Letulé, Eva Stauss, Alison Humphreys, Shramana Banerjee, Annette Klein, Roberta Rotunno, Francesca de Terlizzi, Julie Gehl
BACKGROUND: Cutaneous recurrence from breast cancer can pose a clinical challenge. It might be the only disease site, or could be part of disseminated disease, and often profoundly affects quality of life. Electrochemotherapy is a palliative treatment using electric pulses to locally permeabilize tumor cells and thereby significantly increase bleomycin cytotoxicity. Collaborating with the International Network for Sharing Practice on ElectroChemoTherapy (INSPECT), we consecutively and prospectively accrued data on patients treated with electrochemotherapy for cutaneous metastases from breast cancer...
March 14, 2018: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29621662/plasma-membrane-depolarization-and-permeabilization-due-to-electric-pulses-in-cell-lines-of-different-excitability
#2
Janja Dermol-Černe, Damijan Miklavčič, Matej Reberšek, Primož Mekuč, Sylvia M Bardet, Ryan Burke, Delia Arnaud-Cormos, Philippe Leveque, Rodney O'Connor
In electroporation-based medical treatments, excitable tissues are treated, either intentionally (irreversible electroporation of brain cancer, gene electrotransfer or ablation of the heart muscle, gene electrotransfer of skeletal muscles), or unintentionally (excitable tissues near the target area). We investigated how excitable and non-excitable cells respond to electric pulses, and if electroporation could be an effective treatment of the tumours of the central nervous system. For three non-excitable and one excitable cell line, we determined a strength-duration curve for a single pulse of 10ns-10ms...
March 21, 2018: Bioelectrochemistry
https://www.readbyqxmd.com/read/29577784/updated-standard-operating-procedures-for-electrochemotherapy-of-cutaneous-tumours-and-skin-metastases
#3
Julie Gehl, Gregor Sersa, Louise Wichmann Matthiessen, Tobian Muir, Declan Soden, Antonio Occhini, Pietro Quaglino, Pietro Curatolo, Luca G Campana, Christian Kunte, A James P Clover, Giulia Bertino, Victor Farricha, Joy Odili, Karin Dahlstrom, Marco Benazzo, Lluis M Mir
Electrochemotherapy is now in routine clinical use to treat cutaneous metastases of any histology, and is listed in national and international guidelines for cutaneous metastases and primary skin cancer. Electrochemotherapy is used by dermatologists, surgeons, and oncologists, and for different degrees and manifestations of metastases to skin and primary skin tumours not amenable to surgery. This treatment utilises electric pulses to permeabilize cell membranes in tumours, thus allowing a dramatic increase of the cytotoxicity of anti-cancer agents...
March 25, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29574322/expressional-changes-in-stemness-markers-post-electrochemotherapy-in-pancreatic-cancer-cells
#4
M Shahzad Ali, Kheshwant S Gill, Giuseppe Saglio, Daniela Cilloni, Declan M Soden, Patrick F Forde
Pancreatic cancer is one of the most lethal cancers with high metastatic potential and strong chemoresistance. The capability of a tumor to grow and propagate is dependent on a small subset of cells within a tumor, termed cancer stem cells. Cancer stem cells exhibit great tumorigenicity and are closely correlated with drug resistance and tumor recurrence. The aim of our study was to illustrate electrochemotherapy as an effective treatment for pancreatic cancer along with the expression change in stemness genes (Nanog, Sox2 and Oct3/4) in pancreatic cancer cells post electrochemotherapy with bleomycin, cisplatin and oxaliplatin...
March 15, 2018: Bioelectrochemistry
https://www.readbyqxmd.com/read/29573558/vascularization-of-the-tumours-affects-the-pharmacokinetics-of-bleomycin-and-the-effectiveness-of-electrochemotherapy
#5
Ales Groselj, Simona Kranjc, Masa Bosnjak, Mojca Krzan, Tina Kosjek, Ajda Prevc, Maja Cemazar, Gregor Sersa
Pre-clinical and clinical data indicate differences in the responses of melanoma and carcinoma tumours to electrochemotherapy. The purpose of this study was to investigate the origin of this difference, whether it is due to the intrinsic difference in tumour cell susceptibility to the chemotherapeutic, or due to the tumour microenvironment. For this purpose, we performed a pre-clinical study in B16F1 melanoma and TS/A carcinoma tumours in mice, in which the anti-tumour effectiveness of electrochemotherapy with bleomycin, the intrinsic sensitivity of tumour cells in vitro, the pharmacokinetics of bleomycin in plasma and tumours, and the vascularization of tumours in vivo were evaluated...
March 24, 2018: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29558871/effect-of-electrode-distance-in-grid-electrode-numerical-models-and-in-vitro-tests
#6
Alessia Ongaro, Luca Giovanni Campana, Monica De Mattei, Paolo Di Barba, Fabrizio Dughiero, Michele Forzan, Maria Evelina Mognaschi, Agnese Pellati, Carlo Riccardo Rossi, Clara Bernardello, Elisabetta Sieni
Electrochemotherapy is an emerging local treatment for the management of superficial tumors and, among these, also chest wall recurrences from breast cancer. Generally, the treatment of this peculiar type of tumor requires the coverage of large skin areas. In these cases, electrochemotherapy treatment by means of standard small size needle electrodes (an array of 0.73 cm spaced needles, which covers an area of 1.5 cm2 ) is time-consuming and can allow an inhomogeneous coverage of the target area. We have previously designed grid devices suitable for treating an area ranging from 12 to 200 cm2 ...
January 1, 2018: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/29534581/electrochemotherapy-with-bleomycin-and-cisplatin-enhances-cytotoxicity-in-primary-and-metastatic-uveal-melanoma-cell-lines-in-vitro
#7
M Fiorentzis, H Kalirai, P Katopodis, B Seitz, A Viestenz, S E Coupland
Electrochemotherapy (ECT) enhances responsiveness to cytotoxic drugs in numerous cell lines in vitro. Clinically ECT is widely applied for skin tumor ablation and has shown efficacy in treating non-resectable colorectal liver metastases. There is limited experience of ECT for ocular tumor therapy. We investigated the cytotoxic effect of bleomycin and cisplatin in combination with electroporation on chemoresistant human uveal melanoma (UM) cell lines in vitro. Four UM cell lines (Mel 270, 92-1, OMM-1, OMM-2...
2018: Neoplasma
https://www.readbyqxmd.com/read/29520211/electrochemotherapy-with-bleomycin-of-different-types-of-cutaneous-tumours-in-a-ferret-mustela-putorius-furo
#8
Jozko Racnik, Tanja Svara, Marko Zadravec, Mitja Gombac, Maja Cemazar, Gregor Sersa, Natasa Tozon
Background: Mast cell tumour, sebaceous gland adenoma, and less common squamous papilloma are skin tumours in ferrets ( Mustela putorius furo ), and early excisional surgery is usually the treatment of choice. The aim of our study was to investigate the effectiveness of electrochemotherapy (ECT), a new, minimally invasive non-surgical method, as first treatment option of different types of ferret skin tumours located on surgically difficult sites. Materials and methods: A 5-year-old castrated male ferret with two cutaneous masses, presenting 4 months apart and a 7-year-old spayed female ferret with two cutaneous masses, that appeared simultaneously on two locations are presented...
March 2018: Radiology and Oncology
https://www.readbyqxmd.com/read/29474886/patient-reported-outcomes-in-prospective-cohort-study-of-electrochemotherapy
#9
N Al-Hadithy, Alexandra Dehnel, Alexander George, Robert Kisiel, Craig Lunt, Christopher Stone
Metastatic spread of malignant tumours to skin is a well described phenomenon with incidence of approximately 0.7-9% of all metastases depending on histological type of primary cancer. Electrochemotherapy (ECT) is an efficient local tumour ablation modality that has proven clinical efficacy in the treatment of various types of tumours metastasis to skin. Aims of this study are to evaluate the activity, toxicity, and feasibility of treating patients with electrochemotherapy (ECT); their clinical outcomes and patient report outcome measures...
February 20, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29456474/electrochemotherapy-in-breast-cancer-discussion-of-the-method-and-literature-review
#10
REVIEW
Mateusz Wichtowski, Dawid Murawa, Katarzyna Kulcenty, Karolina Zaleska
Breast cancer is the most common cause of skin metastases in women. The probability of their occurrence ranges from about 5% in the entire population to as much as 30% in the late stages of the disease. Although rarely life-threatening, they have a major impact on the quality of life of patients with this diagnosis, being the cause of pain, effusion, ulceration, infection, and psychological discomfort. Available methods of treatment, both local and systemic, often fail to provide adequate control of the disease...
December 2017: Breast Care
https://www.readbyqxmd.com/read/29408339/icos-activation-in-combination-with-electrochemotherapy-generates-effective-anti-cancer-immunological-responses-in-murine-models-of-primary-secondary-and-metastatic-disease
#11
Liam Friel Tremble, Morgan A O'Brien, Patrick F Forde, Declan M Soden
Electrochemotherapy is an evolving therapy which has recently been shown to induce an immunogenic form of cell death. It is hypothesized that the immunogenic cell death induced by electrochemotherapy may compliment the responses seen with anti-cancer immunotherapies. We therefore examined the effect of electrochemotherapy in combination with ICOS activation, which promotes the activity of previously activated T cells. In comparison to either monotherapy which resulted in no curative outcomes in any model, in a CT26 primary tumour 50% of mice were cured, with 100% of cured mice surviving tumour rechallenge...
February 3, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29402556/electrochemotherapy-as-treatment-option-for-hepatocellular-carcinoma-a-prospective-pilot-study
#12
Mihajlo Djokic, Maja Cemazar, Peter Popovic, Bor Kos, Rok Dezman, Masa Bosnjak, Martina Niksic Zakelj, Damijan Miklavcic, Stojan Potrc, Borut Stabuc, Ales Tomazic, Gregor Sersa, Blaz Trotovsek
BACKGROUND AND OBJECTIVES: Electrochemotherapy provides non-thermal ablation of cutaneous as well as deep seated tumors. Based on positive results of the treatment of colorectal liver metastases, we conducted a prospective pilot study on hepatocellular carcinomas with the aim of testing the feasibility, safety and effectiveness of electrochemotherapy. PATIENTS AND METHODS: Electrochemotherapy with bleomycin was performed on 17 hepatocellular carcinomas in 10 patients using a previously established protocol...
February 2, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29368221/successful-treatment-of-a-keratoacanthoma-with-electrochemotherapy-a-case-report
#13
Paola Pasquali, Enrico P Spugnini, Alfonso Baldi
INTRODUCTION: Few studies have evaluated the efficacy of intralesional bleomycin injection combined with electroporation for the treatment of cutaneous tumors. However, the phenomenon that electroporation can enhance the cytotoxicity of bleomycin in vivo by 300-700 fold has been intensely investigated. CASE PRESENTATION: Keratoacanthoma in an 86-year-old patient was treated with intralesional bleomycin combined with electroporation. Treatment consisted of local application of shorty and intense electric pulses followed by local injection of bleomycin...
January 24, 2018: Dermatology and Therapy
https://www.readbyqxmd.com/read/29333121/minimally-invasive-electrochemotherapy-procedure-for-treating-nasal-duct-tumors-in-dogs-using-a-single-needle-electrode
#14
Felipe Maglietti, Matías Tellado, Nahuel Olaiz, Sebastian Michinski, Guillermo Marshall
Background: Nasal cavity tumors are usually diagnosed late, when they already have infiltrated adjacent tissues thus requiring very aggressive treatments with serious side effects. Here we use electrochemotherapy (ECT), a well demonstrated treatment modality for superficial tumors. Materials and methods: In the case of deep-seated tumors, the main limitation of ECT is reaching the tumor with an appropriate electric field. To overcome this limitation we introduce the single needle electrode (SiNE), a minimally invasive device that can deliver an appropriate electric field with a simple procedure...
December 2017: Radiology and Oncology
https://www.readbyqxmd.com/read/29290813/parametric-optimization-of-electric-field-strength-for-cancer-electrochemotherapy-on-a-chip-based-model
#15
Deyao Zhao, Mengxi Wu, Dong Huang, Zicai Liang, Zewen Wei, Zhihong Li
Electrochemotherapy (ECT), as one of the very few available treatments for cutaneous and subcutaneous tumors when surgery and radiotherapy are no longer available, requires applying a proper electric field to the tumor to realize electroporation-mediated cytotoxic drug delivery. It is impossible to exhaust all possible electrical parameters on patients to realize the optimal tradeoff between tumor suppression and adverse effects. To address this issue, this study provides a feasible solution by developing a four-leaf micro-electrode chip (F-MEC) in which the electric field was specially designed by linear distribution to cover all possible electric field strengths for ECT...
2018: Theranostics
https://www.readbyqxmd.com/read/29289825/in-vitro-electroporation-detection-methods-an-overview
#16
REVIEW
Tina Batista Napotnik, Damijan Miklavčič
Exposing cells to an electric field leads to electroporation of the cell membrane which has already been explored and used in a number of applications in medicine and food biotechnology (e.g. electrochemotherapy, gene electrotransfer, extraction of biomolecules). The extent of electroporation depends on several conditions, including pulse parameters, types of cells and tissues, surrounding media, temperature etc. Each application requires a specific level of electroporation, so it must be explored in advance by employing methods for detecting electroporation...
April 2018: Bioelectrochemistry
https://www.readbyqxmd.com/read/29225870/prostate-cancer-infiltrating-the-bladder-sphincter-successfully-treated-with-electrochemotherapy-a-case-report
#17
Nina Klein, Enric Gunther, Stefan Zapf, Rachid El-Idrissi, Johannes Atta, Michael Stehling
We demonstrate feasibility and safety of Electrochemotherapy for treatment of a prostate cancer (PCa) with infiltration of the urethral sphincter. The patient remained continent and potent, toxicity was low, and 6 months of follow-up showed no cancer activity. We conclude that Electrochemotherapy should be further evaluated as treatment strategy for locally advanced PCa.
December 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/29178483/electrochemotherapy-of-unresectable-cutaneous-tumours-with-reduced-dosages-of-intravenous-bleomycin-analysis-of-57-patients-from-the-international-network-for-sharing-practices-of-electrochemotherapy-registry
#18
R Rotunno, L G Campana, P Quaglino, F de Terlizzi, C Kunte, J Odili, J Gehl, S Ribero, S H Liew, R Marconato, M Brizio, P Curatolo
BACKGROUND: Electrochemotherapy (ECT) is currently used to treat unresectable superficial tumours of different histotypes through the combination of cytotoxic chemotherapy and local application of electric pulses. In 2006, a collaborative project defined the ESOPE (European Standard Operating Procedures of Electrochemotherapy) guidelines to standardize the procedure. The International Network for Sharing Practices of Electrochemotherapy (InspECT) aims to refine the ESOPE and improve clinical practice...
November 24, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29156298/european-research-on-electrochemotherapy-in-head-and-neck-cancer-eureca-project-results-from-the-treatment-of-mucosal-cancers
#19
MULTICENTER STUDY
Christina Caroline Plaschke, Giulia Bertino, James A McCaul, Juan J Grau, Remco de Bree, Gregor Sersa, Antonio Occhini, Ales Groselj, Cristobal Langdon, Derrek A Heuveling, Maja Cemazar, Primoz Strojan, C Rene Leemans, Marco Benazzo, Francesca De Terlizzi, Irene Wessel, Julie Gehl
AIM: Electrochemotherapy is an effective local treatment for cutaneous tumours and metastases. In this prospective trial, six European institutions investigated electrochemotherapy in recurrent, mucosal head and neck tumours. PATIENT AND METHODS: Forty-three patients with recurrent mucosal head and neck tumours and no further curative or reasonably effective palliative treatment options were enrolled and treated with electrochemotherapy. Patients were treated in general anaesthesia using intravenous or local injection of bleomycin followed by delivery of electric pulses to the tumour area...
December 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/29145885/future-perspectives-in-melanoma-research-melanoma-bridge-napoli-november-30th-3rd-december-2016
#20
Paolo A Ascierto, Sanjiv S Agarwala, Gennaro Ciliberto, Sandra Demaria, Reinhard Dummer, Connie P M Duong, Soldano Ferrone, Silvia C Formenti, Claus Garbe, Ruth Halaban, Samir Khleif, Jason J Luke, Lluis M Mir, Willem W Overwijk, Michael Postow, Igor Puzanov, Paul Sondel, Janis M Taube, Per Thor Straten, David F Stroncek, Jennifer A Wargo, Hassane Zarour, Magdalena Thurin
Major advances have been made in the treatment of cancer with targeted therapy and immunotherapy; several FDA-approved agents with associated improvement of 1-year survival rates became available for stage IV melanoma patients. Before 2010, the 1-year survival were quite low, at 30%; in 2011, the rise to nearly 50% in the setting of treatment with Ipilimumab, and rise to 70% with BRAF inhibitor monotherapy in 2013 was observed. Even more impressive are 1-year survival rates considering combination strategies with both targeted therapy and immunotherapy, now exceeding 80%...
November 16, 2017: Journal of Translational Medicine
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