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Electrochemotherapy

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https://www.readbyqxmd.com/read/27920629/electrochemotherapy-in-the-treatment-of-massive-multisite-breast-cancer-metastasis-to-the-skin-and-subcutaneous-tissue-a-case-report
#1
Mateusz Wichtowski, Paweł Potocki, Joanna Kufel-Grabowska, Joanna Streb, Dawid Murawa
BACKGROUND: Chest wall recurrence (CWR) from breast cancer after mastectomy is a difficult to treat disease. Electrochemotherapy (ECT) provides a safe, efficient, and non-invasive locoregional treatment approach in this setting. CASE REPORT: A 61-year-old woman presented with unresectable breast cancer recurrence to the skin and subcutaneous tissue for which numerous lines of treatment were unsuccessful. Between February 2015 and May 2015, the patient underwent 3 courses of ECT after which a spectacular regression of the cutaneous metastatic foci was observed...
October 2016: Breast Care
https://www.readbyqxmd.com/read/27920565/electrochemotherapy-induces-apoptotic-death-in-melanoma-metastases-a-histologic-and-immunohistochemical-investigation
#2
Laura Bigi, Giovanna Galdo, Anna Maria Cesinaro, Cristina Vaschieri, Alessandra Marconi, Carlo Pincelli, Fabrizio Fantini
BACKGROUND: Electrochemotherapy (ECT) is increasingly used in the treatment of primary and secondary skin tumors, but little is known about the pathologic mechanism responsible for tumor cell destruction in humans. Knowledge of detailed mechanism of host response after ECT may improve the treatment efficacy related to patient selection and technique refinements. AIM: The aim of the study was to investigate the histopathology and mechanism of cell death after ECT in cutaneous melanoma metastases...
2016: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/27878392/effective-treatment-of-intractable-cutaneous-metastases-of-breast-cancer-with-electrochemotherapy-ten-year-audit-of-single-centre-experience
#3
Mike G Bourke, Slav P Salwa, Mira Sadadcharam, Maria C Whelan, Patrick F Forde, John O Larkin, Chris G Collins, Seamus O'Reilly, Gerald C O'Sullivan, A James Clover, Declan M Soden
PURPOSE: Electrochemotherapy (ECT) is the application of electric pulses to tumour tissue to render the cell membranes permeable to usually impermeant hydrophilic anti-cancer drugs, thereby enhancing cytotoxic effects. We sought to ascertain whether ECT can be an effective palliative treatment for cutaneous metastases of breast cancer. METHODS: This work reports data from the European Standard Operating Procedures for Electrochemotherapy trial (EudraCT Number: 2004-002183-18)...
November 22, 2016: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/27810205/electroporation-in-veterinary-oncology
#4
REVIEW
J Impellizeri, L Aurisicchio, P Forde, D M Soden
Cancer treatments in veterinary medicine continue to evolve beyond the established standard therapies of surgery, chemotherapy and radiation therapy. New technologies in cancer therapy include a targeted mechanism to open the cell membrane based on electroporation, driving therapeutic agents, such as chemotherapy (electro-chemotherapy), for local control of cancer, or delivery of gene-based products (electro-gene therapy), directly into the cancer cell to achieve systemic control. This review examines electrochemotherapy and electro-gene therapy in veterinary medicine and considers future directions and applications...
November 2016: Veterinary Journal
https://www.readbyqxmd.com/read/27805594/operating-procedures-of-the-electrochemotherapy-for-treatment-of-tumor-in-dogs-and-cats
#5
Natasa Tozon, Ursa Lampreht Tratar, Katarina Znidar, Gregor Sersa, Justin Teissie, Maja Cemazar
Electrochemotherapy (ECT) is a local approach which is used for treating solid tumors of different histologies. Its mechanism is based on cell membrane permeabilization by means of "electroporation". To achieve the "electroporation" of the cells, electric pulses are generated by a generator and delivered to the target tissue by the use of electrodes. Electroporation is a physical method which is used to introduce molecules, like cytostatic drugs, into the cells that could not pass the cell membrane on their own...
October 24, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27769538/electrochemotherapy-for-the-treatment-of-unresectable-locoregionally-advanced-cutaneous-melanoma-a-systematic-review
#6
M J Aguado-Romeo, S Benot-López, A Romero-Tabares
Electrochemotherapy is a therapeutic option for the treatment of cutaneous and subcutaneous metastases from melanoma and other tumors. The procedure consists of the administration of anticancer drugs followed by locally applied electrical impulses to achieve an effect known as electroporation, which facilitates entry into the cytosol of drugs that cannot cross the cell membrane. The aim of this review is to evaluate the evidence that supports the use of electrochemotherapy as a therapeutic strategy in melanoma...
October 18, 2016: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/27758950/electrochemotherapy-as-a-single-or-adjuvant-treatment-to-surgery-of-cutaneous-sarcoid-tumours-in-horses-a-31-case-retrospective-study
#7
N Tozon, P Kramaric, V Kos Kadunc, G Sersa, M Cemazar
The aim of our study was to evaluate the efficacy of electrochemotherapy (ECT) with cisplatin as a single or adjuvant treatment for sarcoids in equids. Different treatment options with different success rates were proposed. Thirty-one horses and one donkey with different clinical type, size and location of tumours were treated with ECT as a single treatment (18 animals with 52 tumour nodules) or as adjuvant treatment with marginal surgical excision (14 animals with 18 tumour nodules). In animals treated only with ECT with cisplatin, complete response was obtained in 48/52 (92...
October 7, 2016: Veterinary Record
https://www.readbyqxmd.com/read/27705053/electrochemotherapy-of-mucosal-head-and-neck-tumors-a-systematic-review
#8
Christina Caroline Plaschke, Anita Gothelf, Julie Gehl, Irene Wessel
BACKGROUND: Electrochemotherapy, the combination of electroporation and chemotherapy, is mainly used in the palliative setting for treatment of cutaneous and subcutaneous metastases; however, new applications are continuously being explored. Patients with head and neck cancer are primarily treated with surgery and/or radio-chemotherapy. In the setting of local recurrence with no further curative treatment options available, electrochemotherapy could be of value. We therefore performed a systematic search of the present literature...
October 5, 2016: Acta Oncologica
https://www.readbyqxmd.com/read/27696129/microscopic-histological-characteristics-of-soft-tissue-sarcomas-analysis-of-tissue-features-and-electrical-resistance
#9
A L Tosi, L G Campana, F Dughiero, M Forzan, M Rastrelli, E Sieni, C R Rossi
Tissue electrical conductivity is correlated with tissue characteristics. In this work, some soft tissue sarcomas (STS) excised from patients have been evaluated in terms of histological characteristics (cell size and density) and electrical resistance. The electrical resistance has been measured using the ex vivo study on soft tissue tumors electrical characteristics (ESTTE) protocol proposed by the authors in order to study electrical resistance of surgical samples excised by patients in a fixed measurement setup...
October 1, 2016: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/27679547/metastatic-sebaceous-cell-carcinoma-review-of-the-literature-and-use-of-electrochemotherapy-as-possible-new-treatment-modality
#10
Simone Ribero, Eugenio Sportoletti Baduel, Matteo Brizio, Franco Picciotto, Emi Dika, Maria Teresa Fierro, Giuseppe Macripò, Pietro Quaglino
BACKGROUND: Metastatic extraorbital sebaceous carcinoma is a rare event that could involve the head and neck. The treatment of choice for the initial stage of the disease is surgery and/or radiotherapy. The treatment of recurrent or advanced disease is still controversial. MATERIAL AND METHODS: Extensive literature search was done, and the treatment options are discussed. RESULTS: Results. The literature search found several treatment modalities in use for the treatment of metastatic extraorbital sebaceous carcinoma...
September 1, 2016: Radiology and Oncology
https://www.readbyqxmd.com/read/27679543/electrochemotherapy-with-bleomycin-is-effective-in-braf-mutated-melanoma-cells-and-interacts-with-braf-inhibitors
#11
Tanja Dolinsek, Lara Prosen, Maja Cemazar, Tjasa Potocnik, Gregor Sersa
BACKGROUND: The aim of the study was to explore the effectiveness of electrochemotherapy (ECT) during the treatment of melanoma patients with BRAF inhibitors. Its effectiveness was tested on BRAF mutated and non-mutated melanoma cells in vitro and in combination with BRAF inhibitors. MATERIALS AND METHODS: ECT with bleomycin was performed on two human melanoma cell lines, with (SK-MEL-28) or without (CHL-1) BRAF V600E mutation. Cell survival was determined using clonogenic assay to determine the effectiveness of ECT in melanoma cells of different mutation status...
September 1, 2016: Radiology and Oncology
https://www.readbyqxmd.com/read/27658910/mathematical-model-of-tumor-volume-dynamics-in-mice-treated-with-electrochemotherapy
#12
Tadeja Forjanič, Damijan Miklavčič
The effectiveness of electrochemotherapy, a local treatment using electric pulses to increase the uptake of chemotherapeutic drug, includes several antitumor mechanisms. In addition to the cytotoxic action of chemotherapeutic drug, treatment outcome also depends on antitumor immune response. In order to assess the contribution of different antitumor mechanisms to the observed treatment outcome, we designed a model of tumor volume dynamics, which is able to quantify early and late treatment effects. Model integrates characteristics of both main posttreatment processes, namely removal of lethally damaged cells from tumor volume and tumor-immune interaction...
September 22, 2016: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/27644612/potential-role-of-electrochemotherapy-as-anticancer-treatment-for-cutaneous-and-subcutaneous-lesions
#13
Anna Zygogianni, George Kyrgias, John Scarlatos, Michael Koukourakis, Kyriakos Souliotis, John Kouvaris, Nikolaos Kelekis, Vassilis Kouloulias
BACKGROUND: The aim of this study was to investigate whether electrochemotherapy is a clinically and cost-effective treatment option against skin tumors. MATERIALS AND METHODS: We performed an analysis of the current literature based on database searches in PubMed/MEDLINE and we included articles till July 2012. Terms used for the search were 'electrochemotherapy', 'skin cancer', 'recurrence', and 'cutaneous and subcutaneous tumors'. Only papers published in English were included...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27595201/electrochemotherapy-with-intravenous-bleomycin-for-advanced-non-melanoma-skin-cancers-and-for-cutaneous-and-subcutaneous-metastases-from-melanoma
#14
Gian M Tomassini, Piero Covarelli, Marco A Tomassini, Alessia Corsi, Leonardo Bianchi, Katharina Hansel, Luca Stingeni
BACKGROUND: The treatment of cutaneous advanced non-melanoma skin cancers (NMSC) and multiple cutaneous and subcutaneous melanoma metastases (Mm) represents a main therapeutic challenge. Electrochemotherapy (ECT) is an anticancer procedure that facilitates the penetration of cytotoxic drugs into cancer cells by means of the application of electrical pulses. The aim of our study was to evaluate efficacy and tolerability of ECT in the treatment of advanced NMSC and Mm. METHODS: Thirteen patients with a total of 88 cutaneous and subcutaneous tumour lesions were selected (69 Mm in 6 patients and 19 NMSC in 7 patients)...
October 2016: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/27591601/identification-and-quantification-of-bleomycin-in-serum-and-tumor-tissue-by-liquid-chromatography-coupled-to-high-resolution-mass-spectrometry
#15
Tina Kosjek, Anja Krajnc, Tjasa Gornik, Dusan Zigon, Ales Groselj, Gregor Sersa, Maja Cemazar
Bleomycin is a cytotoxic antibiotic available as a compost of structurally strongly related glycopeptides, which is in vivo found chelated with several metals. Its pharmacotherapy has merely been based on experimental dose - response data, whereas its biodistribution and pharmacokinetics remain fundamentally unknown. This is reasoned by an absence of a specific and sensitive mass spectrometry-based analytical method for its determination in biological tissues. We herein reveal the results of our study on the mass spectrometric behavior of two main bleomycin fractions A2 and B2, including their metal complexes, particularly the predominant copper chelates...
November 1, 2016: Talanta
https://www.readbyqxmd.com/read/27571558/-electrochemotherapy-mechanism-of-action-and-clinical-results-in-the-locoregional-treatment-of-patients-with-skin-cancers-and-superficial-metastases
#16
Luca Giovanni Campana, Roberto Marconato, Elisabetta Sieni, Sara Valpione, Luigi Corti, Simone Mocellin, Carlo Riccardo Rossi
Electrochemotherapy (ECT) has emerged among European centers as an innovative locoregional treatment for patients with unresectable skin cancers or superficial metastases from any histotype. The combined administration of a cytotoxic agent (bleomycin or cisplatin) with properly tuned electric pulses results in locally-enhanced drug delivery (reversible electroporation) into malignant cells and sustained tumor response. Reversible electroporation represents the basis of ECT and allows the potentiation of two low permeant cytotoxic agents such as bleomycin (~8000 fold) and cisplatin (~80 fold)...
August 2016: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/27475809/cd4-foxp3-t-regulatory-cells-decrease-and-cd3-cd8-t-cells-recruitment-in-tils-from-melanoma-metastases-after-electrochemotherapy
#17
P Di Gennaro, G Gerlini, C Urso, S Sestini, P Brandani, N Pimpinelli, L Borgognoni
Electrochemotherapy (ECT) represents an effective local treatment for skin unresectable melanoma metastases with high overall objective response rate. ECT is based on the combination of anti-neoplastic drugs administration and cancer cells electroporation. Whether ECT can also activate the immune system is a matter of debate, however a significant recruitment of dendritic cells in melanoma treated metastases has been described. Herein we investigated immediate and late effects of ECT treatment on T cell subsets in ECT-treated lesions by fluorescent immunohistochemistry...
December 2016: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/27466265/local-tumor-treatment-in-combination-with-systemic-ipilimumab-immunotherapy-prolongs-overall-survival-in-patients-with-advanced-malignant-melanoma
#18
Sebastian Theurich, Sacha I Rothschild, Michael Hoffmann, Mario Fabri, Andrea Sommer, Maria Garcia-Marquez, Martin Thelen, Catherine Schill, Ramona Merki, Thomas Schmid, Dieter Koeberle, Alfred Zippelius, Christian Baues, Cornelia Mauch, Christian Tigges, Alexander Kreuter, Jan Borggrefe, Michael von Bergwelt-Baildon, Max Schlaak
Immune checkpoint inhibition with ipilimumab has revolutionized cancer immunotherapy and significantly improved outcomes of patients with advanced malignant melanoma. Local peripheral treatments (LPT), such as radiotherapy or electrochemotherapy, have been shown to modulate systemic immune responses, and preliminary data have raised the hypothesis that the combination of LPT with systemic immune checkpoint blockade might be beneficial. Clinical data from 127 consecutively treated melanoma patients at four cancer centers in Germany and Switzerland were analyzed...
September 2, 2016: Cancer Immunology Research
https://www.readbyqxmd.com/read/27464761/novel-instruments-for-the-implementation-of-electrochemotherapy-protocols-from-bench-side-to-veterinary-clinic
#19
REVIEW
Enrico P Spugnini, Stefano Fais, Tommaso Azzarito, Alfonso Baldi
Electrochemotherapy (ECT) is a medical strategy that allows an increased efficacy of chemotherapy agents after the application of permeabilizing electric pulses having appropriate characteristics (form, voltage, frequency). In the past 10 years, the clinical efficacy of this therapeutic approach in several spontaneous models of tumors in animals has been shown. Moreover, some of the molecular and cellular mechanisms responsible for this phenomenon have been elucidated. Our group has been deeply involved in the development of new ECT protocols for companion animals, implementing the use of the technique as first line treatment, and evaluating different chemotherapy agents in laboratory animals as well as pets...
July 28, 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/27454174/cell-electrosensitization-exists-only-in-certain-electroporation-buffers
#20
Janja Dermol, Olga N Pakhomova, Andrei G Pakhomov, Damijan Miklavčič
Electroporation-induced cell sensitization was described as the occurrence of a delayed hypersensitivity to electric pulses caused by pretreating cells with electric pulses. It was achieved by increasing the duration of the electroporation treatment at the same cumulative energy input. It could be exploited in electroporation-based treatments such as electrochemotherapy and tissue ablation with irreversible electroporation. The mechanisms responsible for cell sensitization, however, have not yet been identified...
2016: PloS One
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