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Electrochemotherapy

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https://www.readbyqxmd.com/read/29027689/oral-mucosa-model-for-electrochemotherapy-treatment-of-dog-mouth-cancer-ex-vivo-in-silico-and-in-vivo-experiments
#1
Daniela O H Suzuki, José A Berkenbrock, Marisa J S Frederico, Fátima R M B Silva, Marcelo M M Rangel
Electrochemotherapy (EQT) is a local cancer treatment well established to cutaneous and subcutaneous tumors. Electric fields are applied to biological tissue in order to improve membrane permeability for cytotoxic drugs. This phenomenon is called electroporation or electropermeabilization. Studies have reported that tissue conductivity is electric field dependent. Electroporation numerical models of biological tissues are essential in treatment planning. Tumors of the mouth are very common in dogs. Inadequate EQT treatment of oral tumor may be caused by significant anatomic variations between dogs and tumor position...
October 13, 2017: Artificial Organs
https://www.readbyqxmd.com/read/29025611/carbon-fiber-reinforced-intramedullary-nailing-in-musculoskeletal-tumor-surgery-a-national-multicentric-experience-of-the-italian-orthopaedic-society-siot-bone-metastasis-study-group
#2
Andrea Piccioli, Raimondo Piana, Michele Lisanti, Alberto Di Martino, Barbara Rossi, Francesco Camnasio, Marco Gatti, Pietro Maniscalco, Franco Gherlinzoni, Maria Silvia Spinelli, Davide Maria Donati, Roberto Biagini, Rodolfo Capanna, Vincenzo Denaro
INTRODUCTION: Carbon fiber reinforced (CFR) implants have been proposed for the treatment of fractures or impending fractures of the long bones in the oncology patient. Aim of this study is to present the largest cohort of oncology patients operated by CFR nailing by the Italian Orthopaedic Society (SIOT) Bone Metastasis Study Group. METHODS: 53 adult oncology patients were operated on with a CFR-PEEK nail. All the data from adjuvants therapies were collected. Bone callus formation, response to radiotherapy, relapse or progression of the osteolysis were recorded...
October 2017: Injury
https://www.readbyqxmd.com/read/29024870/comparable-effectiveness-and-immunomodulatory-actions-of-oxaliplatin-and-cisplatin-in-electrochemotherapy-of-murine-melanoma
#3
Katja Ursic, Spela Kos, Urska Kamensek, Maja Cemazar, Janez Scancar, Simon Bucek, Simona Kranjc, Barbara Staresinic, Gregor Sersa
Interest in platinum-based chemotherapeutics such as oxaliplatin (OXA) and cisplatin (CDDP) has been reinvigorated by their newly described impacts on tumor-specific immune responses. In addition to CDDP, OXA is frequently used to treat cancers. Based on the characteristics of OXA, which are similar to those of CDDP, and the presumably more pronounced immunomodulatory effect of OXA, OXA is a candidate for electrochemotherapy (ECT). We compared the effectiveness of intratumoral ECT with OXA to that of ECT with CDDP in murine B16F10 melanoma to determine the equieffective dose...
October 3, 2017: Bioelectrochemistry
https://www.readbyqxmd.com/read/28980041/physical-methods-for-drug-and-gene-delivery-through-the-cell-plasma-membrane
#4
Milda Jakutavičiūtė, Paulius Ruzgys, Mindaugas Tamošiūnas, Martynas Maciulevičius, Saulius Šatkauskas
The cell membrane represents a major barrier for efficient delivery of exogenous molecules, either pharmaceuticals or genetic material, under both in vitro and in vivo conditions. The number of methods employed to attempt safe, efficient, and local drug and gene delivery has increased during the recent years. One method for membrane permeabilization, electroporation, has already been translated to clinical practice for localized anticancer drug delivery and is termed "electrochemotherapy". Clinical trials for gene delivery using electroporation as well as drug delivery using another cell permeabilization method, sonoporation, are also underway...
2017: Advances in Anatomy, Embryology, and Cell Biology
https://www.readbyqxmd.com/read/28959168/electrochemotherapy-supplementary-treatment-for-loco-regional-metastasized-breast-carcinoma-administered-to-concomitant-systemic-therapy
#5
Eva-Maria Grischke, Carmen Röhm, Eva Stauß, Florin-Andrei Taran, Sara Y Brucker, Diethelm Wallwiener
BACKGROUND: Electrochemotherapy (ECT) is an established procedure for treating breast cancer loco-regional recurrences following surgical intervention and/or radiotherapy. Limited information is available on ECT application as a concomitant procedure to systemic therapy in recurrent breast cancer. The primary objective of this study was to determine if the application of ECT in close temporal relation to systemic chemotherapy could lead to increased local and/or systemic side effects...
September 2017: Radiology and Oncology
https://www.readbyqxmd.com/read/28959166/in-vitro-and-in-vivo-evaluation-of-electrochemotherapy-with-trans-platinum-analogue-trans-ptcl2-3-hmpy-2
#6
Simona Kranjc, Maja Cemazar, Gregor Sersa, Janez Scancar, Sabina Grabner
BACKGROUND: Cisplatin is used in cancer therapy, but its side effects and acquired resistance to cisplatin have led to the synthesis and evaluation of new platinum compounds. Recently, the synthesized platinum compound trans-[PtCl2(3-Hmpy)2] (3-Hmpy = 3-hydroxymethylpyridine) (compound 2) showed a considerable cytotoxic and antitumour effectiveness. To improve compound 2 cytotoxicity in vitro and antitumour effectiveness in vivo, electroporation was used as drug delivery approach to increase membrane permeability (electrochemotherapy)...
September 2017: Radiology and Oncology
https://www.readbyqxmd.com/read/28959165/effects-of-electrochemotherapy-with-cisplatin-and-peritumoral-il-12-gene-electrotransfer-on-canine-mast-cell-tumors-a-histopathologic-and-immunohistochemical-study
#7
Claudia Salvadori, Tanja Svara, Guido Rocchigiani, Francesca Millanta, Darja Pavlin, Maja Cemazar, Ursa Lampreht Tratar, Gregor Sersa, Natasa Tozon, Alessandro Poli
BACKGROUND: The study was aimed to characterize tumor response after combined treatment employing electrochemotherapy with IL-12 gene electrotransfer in dogs with spontaneous mast cell tumors (MCT). MATERIALS AND METHODS: Eleven dogs with eleven MCTs were included in the study. Histological changes were investigated in biopsy specimens collected before the treatment (T0), and 4 (T1) and 8 weeks (T2) later. Cellular infiltrates were characterized immunohistochemically by using anti CD3, CD20, Foxp3 (Treg), CD68 and anti MHC-class II antibodies...
September 2017: Radiology and Oncology
https://www.readbyqxmd.com/read/28871138/predicting-irreversible-electroporation-induced-tissue-damage-by-means-of-magnetic-resonance-electrical-impedance-tomography
#8
Matej Kranjc, Simona Kranjc, Franci Bajd, Gregor Serša, Igor Serša, Damijan Miklavčič
Irreversible electroporation (IRE) is gaining importance in routine clinical practice for nonthermal ablation of solid tumors. For its success, it is extremely important that the coverage and exposure time of the treated tumor to the electric field is within the specified range. Measurement of electric field distribution during the electroporation treatment can be achieved using magnetic resonance electrical impedance tomography (MREIT). Here, we show improved MREIT-enabled electroporation monitoring of IRE-treated tumors by predicting IRE-ablated tumor areas during IRE of mouse tumors in vivo...
September 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28816072/calcium-electroporation-for-treatment-of-cutaneous-metastases-a-randomized-double-blinded-phase-ii-study-comparing-the-effect-of-calcium-electroporation-with-electrochemotherapy
#9
H Falk, L W Matthiessen, G Wooler, J Gehl
BACKGROUND: Calcium electroporation is a novel anticancer treatment, which utilizes high voltage pulses to permeabilize cell membranes and expose the cell to supraphysiological doses of calcium. Preclinical studies on calcium electroporation have shown strikingly high tumor response with cell necrosis. Calcium electroporation builds on the treatment electrochemotherapy, where chemotherapeutic drugs, mostly bleomycin, are internalized by electroporation. This double-blinded randomized study compared calcium electroporation to electrochemotherapy in terms of objective response measured 6 months after treatment...
August 17, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28812409/tumor-reduction-and-symptom-relief-after-electrochemotherapy-in-a-patient-with-aggressive-fibromatosis-a-case-report
#10
Joanna Vitfell-Rasmussen, Rikke Mulvad Sandvik, Karin Dahlstrøm, Gina Al-Farra, Anders Krarup-Hansen, Julie Gehl
No abstract text is available yet for this article.
August 16, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28781865/treatment-of-lymph-node-metastases-from-gastric-cancer-with-a-combination-of-irreversible-electroporation-and-electrochemotherapy-a-case-report
#11
Nina Klein, Stefan Zapf, Enric Gunther, Michael Stehling
The combination of Irreversible Electroporation and Electrochemotherapy (IRECT) was well tolerated, safe, and had antitumor activity in this case study of a patient with lymph node metastases from gastric cancer. We therefore recommend the consideration of further clinical studies to investigate the treatment of cancerous tissue with IRECT.
August 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28780353/ultra-microsecond-pulsed-curcumin-for-effective-treatment-of-triple-negative-breast-cancers
#12
Lakshya Mittal, Vishak Raman, Ignacio G Camarillo, Raji Sundararajan
Triple negative breast cancer (TNBC) is difficult to treat due to lack of the three receptors, commonly used for treating breast cancers. Current standard of cure is either ineffective or refractive to many patients. Thus, there is a critical need for alternate, affordable therapies for TNBC cancers. Towards this, electrical pulse-mediated chemotherapy, known as electrochemotherapy is a viable option, because it uses the synergy of electrical pulses and the anticancer properties of chemo drug. Considering the cost and the harsh side effects of various commonly administered chemo drugs, in this study, low cost, yet effective, natural phytochemical curcumin is studied for its anticancer effect on MDA-MB-231, TNBC cells...
September 30, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28765698/early-radiological-assessment-of-locally-advanced-pancreatic-cancer-treated-with-electrochemotherapy
#13
Vincenza Granata, Roberta Fusco, Sergio Venanzio Setola, Mauro Piccirillo, Maddalena Leongito, Raffaele Palaia, Francesco Granata, Secondo Lastoria, Francesco Izzo, Antonella Petrillo
AIM: To report early imaging assessment of ablated area post electrochemotherapy (ECT) in patients with locally advanced pancreatic cancer (LAPC). METHODS: ECT was performed in 19 LAPC patients enrolled in an approved ongoing clinical phase I/II study. Before and after ECT, 18 patients underwent computed tomography (CT) scan, 11 patients underwent morphological and functional magnetic resonance (MR) scan (dynamic contrast enhanced-MRI) calculating wash-in slope (WIS) and wash-out slope (WOS); diffusion weighted imaging calculating pseudo-diffusivity (Dp), perfusion fraction (fp) and tissue diffusivity (Dt); 10 patients underwent positron emission tomography (PET)...
July 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28746857/enhancing-irreversible-electroporation-by-manipulating-cellular-biophysics-with-a-molecular-adjuvant
#14
Jill W Ivey, Eduardo L Latouche, Megan L Richards, Glenn J Lesser, Waldemar Debinski, Rafael V Davalos, Scott S Verbridge
Pulsed electric fields applied to cells have been used as an invaluable research tool to enhance delivery of genes or other intracellular cargo, as well as for tumor treatment via electrochemotherapy or tissue ablation. These processes involve the buildup of charge across the cell membrane, with subsequent alteration of transmembrane potential that is a function of cell biophysics and geometry. For traditional electroporation parameters, larger cells experience a greater degree of membrane potential alteration...
July 25, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28736667/changes-in-optical-properties-of-electroporated-cells-as-revealed-by-digital-holographic-microscopy
#15
Violeta L Calin, Mona Mihailescu, Nicolae Mihale, Alexandra V Baluta, Eugenia Kovacs, Tudor Savopol, Mihaela G Moisescu
Changes in optical and shape-related characteristics of B16F10 cells after electroporation were investigated using digital holographic microscopy (DHM). Bipolar rectangular pulses specific for electrochemotherapy were used. Electroporation was performed in an "off-axis" DHM set-up without using exogenous markers. Two types of cell parameters were monitored seconds and minutes after pulse train application: parameters addressing a specifically defined area of the cell (refractive index and cell height) and global cell parameters (projected area, optical phase shift profile and dry mass)...
April 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28717603/isolated-limb-perfusion-electrochemotherapy-for-the-treatment-of-an-advanced-squamous-cell-carcinoma-of-the-hoof-in-a-mare
#16
Enrico Pierluigi Spugnini, Carlo Bolaffio, Licia Scacco, Alfonso Baldi
A twenty-year-old female saddle horse was referred for evaluation of a seven month, non-healing erosive lesion of the right hind hoof with proliferation and bleeding of the underlying soft tissues. This lesion had been twice surgically treated as a canker but rapidly recurred. Histological examination of the second excision revealed a well-differentiated squamous cell carcinoma. At presentation, the horse was mildly depressed, lame and partially non-weight-bearing on the right hind leg, which exhibited a 10 x 10 cm erosive and proliferative lesion remodeling the hoof...
2017: Open veterinary journal
https://www.readbyqxmd.com/read/28686650/histopathological-findings-in-colorectal-liver-metastases-after-electrochemotherapy
#17
Gorana Gasljevic, Ibrahim Edhemovic, Maja Cemazar, Erik Brecelj, Eldar M Gadzijev, Maja M Music, Gregor Sersa
Electrochemotherapy of colorectal liver metastases has been proven to be feasible, safe and effective in a phase I/II study. In that study, a specific group of patients underwent two-stage operation, and the detailed histopathological evaluation of the resected tumors is presented here. Regressive changes in electrochemotherapy-treated liver metastases were evaluated after the second operation (in 8-10 weeks) in 7 patients and 13 metastases when the treated metastases were resected. Macroscopic and microscopic changes were analyzed...
2017: PloS One
https://www.readbyqxmd.com/read/28649271/effect-of-electrochemotherapy-on-human-herpesvirus-8-kinetics-in-classic-kaposi-sarcoma
#18
Noemy Starita, Gianluca Di Monta, Andrea Cerasuolo, Ugo Marone, Anna Maria Anniciello, Gerardo Botti, Luigi Buonaguro, Franco M Buonaguro, Maria Lina Tornesello
BACKGROUND: Electrochemotherapy (ECT) has shown to be an effective treatment for cutaneous and subcutaneous Kaposi sarcoma (KS) lesions. However, no study has investigated the impact of ECT treatment on the kinetics of human herpesvirus type 8 (HHV8), which is considered the necessary causal agent of KS. We aimed to evaluate HHV8 viral load and expression levels in patients affected by classic KS who received one or more ECT treatments and have been followed semi annually for up to four years...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/28641523/radiosensitizing-effect-of-electrochemotherapy-a-systematic-review-of-protocols-and-efficiency
#19
Zohre Rezaee, Ali Yadollahpour, Samaneh Rashidi, Pramod S Kunwar
OBJECTIVE: Electrochemotherapy (ECT) is a combination of electroporation (EP) and chemotherapy and has been reported as a potential radiosensitizing agent for radiation therapy. The main objective of this study was to systematically review of the literature to evaluate the effectiveness of ECT in sensitization of tumors to ionization radiation. In addition, the clinical considerations and mechanisms of action of radiosensitizing effect are discussed. METHODS: The databases of Medline (PubMed), Embase, Scopus, Cochrane library, Web of Science, Biomed central, Science Direct, and Google scholar up to March 30th 2017 were explored...
June 21, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/28638724/calcium-electroporation-induces-tumor-eradication-long-lasting-immunity-and-cytokine-responses-in-the-ct26-colon-cancer-mouse-model
#20
Hanne Falk, Patrick F Forde, Marie Lund Bay, Uma Maheswari Mangalanathan, Pernille Hojman, Declan M Soden, Julie Gehl
Electroporation is used in cancer treatment because of its ability to increase local cytotoxicity of e.g. bleomycin (electrochemotherapy) and calcium (calcium electroporation). Calcium electroporation is a novel anticancer treatment that selectively kills cancer cells by necrosis, a cell death pathway that stimulates the immune system due to high release of antigens and "danger signals." In this exploratory study, we aimed to investigate whether calcium electroporation could initiate an anticancer immune response similar to electrochemotherapy...
2017: Oncoimmunology
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