keyword
https://read.qxmd.com/read/38537153/novel-proteomic-signatures-may-indicate-mri-assessed-intrahepatic-fat-state-and-changes-the-direct-plus-clinical-trial
#1
JOURNAL ARTICLE
Dana T Goldberg, Anat Yaskolka Meir, Gal Tsaban, Ehud Rinott, Alon Kaplan, Hila Zelicha, Nora Klöting, Uta Ceglarek, Berend Iserman, Ilan Shelef, Philip Rosen, Matthias Blüher, Michael Stumvoll, Ohad Etzion, Meir J Stampfer, Frank B Hu, Iris Shai
OBJECTIVE: We demonstrated in the randomized 18-month DIRECT PLUS trial (n=294) that a Mediterranean (MED) diet, supplemented with polyphenol-rich Mankai duckweed, green tea, and walnuts and restricted in red/processed meat, caused substantial intrahepatic fat (IHF%) loss compared with two other healthy diets, reducing NAFLD by half, regardless similar weight loss. Here, we investigated the baseline proteomic profile associated with IHF% and the changes in proteomics associated with IHF% changes induced by lifestyle intervention...
March 27, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/38535961/investigation-of-the-association-between-air-pollution-and-non-alcoholic-fatty-liver-disease-in-the-european-population-a-mendelian-randomization-study
#2
JOURNAL ARTICLE
Jing Yang, Yaqi Zhang, Yin Yuan, Zhongyang Xie, Lanjuan Li
Non-alcoholic fatty liver disease (NAFLD) is currently the most prevalent chronic liver disease worldwide. At the same time, the relationship between air pollution and the likelihood of developing NAFLD has been a subject of debate due to conflicting findings in previous observational research. Our objective was to examine the potential correlation between air pollutant levels and the risk of NAFLD in the European population by employing a two-sample Mendelian randomization (MR) analysis. The UK Biobank Consortium provided the summary statistics for various air pollution indicators (PM2...
March 21, 2024: Toxics
https://read.qxmd.com/read/38535313/interleukins-pathogenesis-in-non-alcoholic-fatty-liver-disease
#3
REVIEW
Saira Rafaqat, Sanja Gluscevic, Filiz Mercantepe, Sana Rafaqat, Aleksandra Klisic
Inflammatory cytokines have been implicated as crucial contributors to the onset and progression of non-alcoholic fatty liver disease (NAFLD). The exact mechanisms by which interleukins (ILs) contribute to NAFLD may vary, and ongoing research is aimed at understanding the specific roles of different ILs in the pathogenesis of this condition. In addition, variations in environmental factors and genetics in each individual can influence the onset and/or progression of NAFLD. The lack of clinical studies related to the potential therapeutic properties of IL-1 inhibitors currently does not allow us to conclude their validity as a therapeutic option, although preclinical studies show promising results...
March 6, 2024: Metabolites
https://read.qxmd.com/read/38534764/bioconversion-pharmacokinetics-and-therapeutic-mechanisms-of-ginsenoside-compound-k-and-its-analogues-for-treating-metabolic-diseases
#4
REVIEW
Md Niaj Morshed, Reshmi Akter, Md Rezaul Karim, Safia Iqbal, Se Chan Kang, Deok Chun Yang
Rare ginsenoside compound K (CK) is an intestinal microbial metabolite with a low natural abundance that is primarily produced by physicochemical processing, side chain modification, or metabolic transformation in the gut. Moreover, CK exhibits potent biological activity compared to primary ginsenosides, which has raised concerns in the field of ginseng research and development, as well as ginsenoside-related dietary supplements and natural products. Ginsenosides Rb1, Rb2, and Rc are generally used as a substrate to generate CK via several bioconversion processes...
March 11, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38533910/unveiling-global-research-trends-and-hotspots-on-mitochondria-in-nafld-from-2000-to-2023-a-bibliometric-analysis
#5
JOURNAL ARTICLE
Jingqin Hu, Ze Chen, Yibing Zhou, Yinglun Li, Jing Liu, Yuqiang Mi, Li Wang, Feng Jiang, Ping Li
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) has garnered significant attention in the past decade as a prevalent chronic liver condition. Despite a growing body of evidence implicating mitochondria in NAFLD development, comprehensive bibliometric analyses within this research domain are scarce. This study aims to provide a thorough overview of the knowledge framework and key research areas related to mitochondria in the context of NAFLD, utilizing bibliometric techniques. METHODS: A comprehensive search of publications on mitochondria in NAFLD from 2000 to 2023 was conducted using the Web of Science Core Collection database...
March 2024: Immunity, Inflammation and Disease
https://read.qxmd.com/read/38533551/inhibitory-protein-protein-interactions-of-the-sirt1-deacetylase-are-choreographed-by-post-translational-modification
#6
JOURNAL ARTICLE
Troy C Krzysiak, You-Jin Choi, Yong Joon Kim, Yunhan Yang, Christopher DeHaven, Lariah Thompson, Ryan Ponticelli, Mara M Mermigos, Laurel Thomas, Andrea Marquez, Ian Sipula, Jongsook Kim Kemper, Michael Jurczak, Gary Thomas, Angela M Gronenborn
Regulation of SIRT1 activity is vital to energy homeostasis and plays important roles in many diseases. We previously showed that insulin triggers the epigenetic regulator DBC1 to prime SIRT1 for repression by the multifunctional trafficking protein PACS-2. Here, we show that liver DBC1/PACS-2 regulates the diurnal inhibition of SIRT1, which is critically important for insulin-dependent switch in fuel metabolism from fat to glucose oxidation. We present the x-ray structure of the DBC1 S1-like domain that binds SIRT1 and an NMR characterization of how the SIRT1 N-terminal region engages DBC1...
April 2024: Protein Science
https://read.qxmd.com/read/38533529/adar2-deficiency-ameliorates-non-alcoholic-fatty-liver-disease-and-muscle-atrophy-through-modulating-serum-amyloid-a1
#7
JOURNAL ARTICLE
Mei-Lang Kung, Tai-Hua Yang, Chia-Chi Lin, Jia-Yun Ho, Tzu-Chi Hung, Chih-Hsiang Chang, Kuan-Wen Huang, Chien-Chin Chen, Yun-Wen Chen
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide. Sarcopenia is a syndrome characterized by progressive and generalized loss of skeletal muscle mass and strength, which is commonly associated with NAFLD. Adenosine-to-inosine editing, catalysed by adenosine deaminase acting on RNA (ADAR), is an important post-transcriptional modification of genome-encoded RNA transcripts. Three ADAR gene family members, including ADAR1, ADAR2 and ADAR3, have been identified...
March 27, 2024: Journal of Cachexia, Sarcopenia and Muscle
https://read.qxmd.com/read/38533453/inter-individual-variations-in-circadian-misalignment-induced-nafld-pathophysiology-in-mice
#8
JOURNAL ARTICLE
Nobuya Koike, Yasuhiro Umemura, Hitoshi Inokawa, Isao Tokuda, Yoshiki Tsuchiya, Yuh Sasawaki, Atsushi Umemura, Naoko Masuzawa, Kazuya Yabumoto, Takashi Seya, Akira Sugimoto, Seung-Hee Yoo, Zheng Chen, Kazuhiro Yagita
Pathological consequences of circadian misalignment, such as shift work, show considerable individual differences, but the lack of mechanistic understanding hinders precision prevention to prevent and mitigate disease symptoms. Here, we employed an integrative approach involving physiological, transcriptional, and histological phenotypes to examine inter-individual differences in pre-symptomatic pathological progression, preceding irreversible disease onset, in wild-type mice exposed to chronic jet-lag (CJL)...
February 16, 2024: IScience
https://read.qxmd.com/read/38533281/efficacy-of-pistacia-lentiscus-plant-rumi-mastagi-in-comparison-to-levosulpiride-in-patients-with-diabetic-gastroparesis-a-double-blind-non-inferior-randomised-control-trial-study
#9
JOURNAL ARTICLE
Ajaypal Singh, Ravi Kant, Rohit Raina, Vandana Dhingra, Rajeev Nema, Mukesh Chand Bairwa, Varsha Kanwar, Rifika L Sukhes Mukherjee, Anissa Atif Mirza, Mayank Agarwal
INTRODUCTION: Gastrointestinal neuropathies are frequently found in diabetic patients. The pathogenesis of diabetic gastroparesis (DG) is multifactorial. The usual treatment for DG includes dietary modifications, prokinetic and antiemetic agents. There is increasing demand for more effective medicines to treat DG. The current study was conducted on the Pistacia lentiscus stem extract to add to the armamentarium of DG treatment and to find the efficacy of P. lentiscus plant extract (mastic gum) in comparison to levosulpiride in DG for improvement in gastroparesis symptoms and gastric emptying scintigraphy (GES) in a single centric double-blind non-inferiority randomised control trial...
2024: Indian Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/38533279/sglt2-inhibitors-paradigm-shift-from-diabetes-care-to-metabolic-care-an-indian-perspective
#10
REVIEW
K M Prasanna Kumar, A G Unnikrishnan, Pankaj Jariwala, Ashwani Mehta, Richa Chaturvedi, Sagar Panchal, Preet Lakhani, Rachana Acharya, Jitendra Dixit
The prevalence and burden of diabetes are on the rise in India, making it 'the diabetes capital of the world'. Comorbidities such as obesity, cardiovascular (CV) complications, chronic kidney disease (CKD), non-alcoholic fatty liver disease (NAFLD), and neurodegenerative diseases are common in patients with diabetes. Recent breakthroughs in diabetes medications and continuous glucose monitoring have resulted in a paradigm shift in diabetes care. Hence, a review in the Indian context is warranted. This review focuses on the existing evidence (gathered by a systematic literature search utilising online databases such as PubMed) on the metabolic, cardio-renoprotective, and hepatoprotective effects of sodium-glucose co-transporter 2 (SGLT2) inhibition, particularly in the Indian setting...
2024: Indian Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/38532896/investigating-the-impact-of-elevated-urinary-trace-elements-on-non-alcoholic-fatty-liver-disease-using-vibration-controlled-transient-elastography
#11
JOURNAL ARTICLE
Chenxiao Wang, Xin Shang, Yu Fu, Panpan Guo, Ping Wang, Shuxun Yan
INTRODUCTION: Non-alcoholic fatty liver disease (NAFLD) is a global public health concern. However, limited data are available on urinary trace elements and NAFLD caused by various exposure factors. This study aimed to investigate the relationship between the presence of 16 trace elements in urine and NAFLD using data from the National Health and Nutrition Examination Survey (NHANES). METHODS: By utilizing the NHANES data from 2017 to 2018, 1613 participants who fulfilled the research criteria were identified from the initial pool of 2979 participants with available urine trace element detection data...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38532480/dihydromyricetin-ameliorates-hepatic-steatosis-and-insulin-resistance-via-ampk-pgc-1%C3%AE-and-ppar%C3%AE-mediated-autophagy-pathway
#12
JOURNAL ARTICLE
Yan Yang, Wen Qiu, Jiyuan Xiao, Jie Sun, Xuan Ren, Luxia Jiang
BACKGROUND: Dihydromyricetin (DHM), a flavonoid compound of natural origin, has been identified in high concentrations in ampelopsis grossedentata and has a broad spectrum of biological and pharmacological functions, particularly in regulating glucose and lipid metabolism. The objective of this research was to examine how DHM affected nonalcoholic fatty liver disease (NAFLD) and its underlying mechanisms involved in the progression of NAFLD in a rat model subjected to a high-fat diet (HFD)...
March 26, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38532322/glp-1-glp-1ras-new-options-for-the-drug-treatment-of-nafld
#13
REVIEW
Haoran Jiang, Linquan Zang
Non-alcoholic fatty liver disease (NAFLD) has recently emerged as a global public health concern. Currently, the cornerstone of NAFLD treatment is lifestyle modification and, if necessary, weight loss. However, compliance is a challenge, and this approach alone may not be sufficient to halt and treat the more serious disease development, so medication is urgently needed. Nevertheless, no medicines are approved to treat NAFLD. Glucagon-like peptide-1 (GLP-1) is an enteropeptide hormone that inhibits glucagon synthesis, promotes insulin secretion, and delays gastric emptying...
2024: Current Pharmaceutical Design
https://read.qxmd.com/read/38531925/comparative-evaluation-of-non-invasive-tests-for-risk-stratification-for-cause-specific-mortality-in-at-risk-population-of-hepatic-fibrosis
#14
JOURNAL ARTICLE
Huiyul Park, Eileen L Yoon, Mimi Kim, Hye-Lin Kim, Mi Kyung Kim, Yu-Mi Kim, Dae Won Jun
Our study aimed to conduct a comparative evaluation of various noninvasive tests (NITs) for risk stratification in at-risk population for non-alcoholic fatty liver disease (NAFLD), focusing on cardiovascular and liver-related mortality. A total of 21,715 adults aged 40 years and older were enrolled at baseline. The mean follow-up period was 12.39 years. Three types of NITs (fibrosis-4 index [FIB-4], NAFLD fibrosis score [NFS], and steatosis-associated fibrosis estimator [SAFE] score) were used. When using the low cut-off as a 'rule-out' strategy, there were no significant differences in cardiovascular mortality between the 'rule-out' (low-risk) group and the 'rule-in' (intermediate- or high-risk) group based on FIB-4 (aHR = 1...
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38531378/new-nomenclature-for-nonalcoholic-fatty-liver-disease-understanding-metabolic-dysfunction-associated-steatotic-liver-disease-metabolic-dysfunction-and-alcohol-associated-liver-disease-and-their-implications-in-clinical-practice
#15
JOURNAL ARTICLE
Clémence M Canivet, Jérôme Boursier, Rohit Loomba
In June 2023, under the patronage of the American Association for Study of Liver Disease, the European Association for Study of the Liver, and the Asociación Latinoamericana para el Estudio del Hígado with the involvement of 236 participants from around the world, a new nomenclature and definition for nonalcoholic fatty liver disease (NAFLD) has been proposed. Metabolic dysfunction-associated steatotic liver disease (MASLD) was defined as presence of hepatic steatosis and at least one of the cardiometabolic risk factors with alcohol intake less than 140 g/wk for women and 210 g/wk for men and no other causes of steatosis...
March 26, 2024: Seminars in Liver Disease
https://read.qxmd.com/read/38531168/effect-of-circadian-rhythm-change-on-gut-microbiota-and-the-development-of-nonalcoholic-fatty-liver-disease-in-mice
#16
JOURNAL ARTICLE
Dan Zhao, Xinxue Wang, Huiwei Liu, Mingli Su, Mengxia Sun, Liangshun Zhang, Hua Ye
BACKGROUND: This study was to investigate the effect and possible mechanism of circadian rhythm change on the development of nonalcoholic fatty liver disease (NAFLD) in mice. METHODS: A total of 80 male SPF-grade 4-week C57BL/6J mice were randomly divided into normal diet normal light/dark cycle (ND-LD) and high-fat diet all dark (HFD-DD) groups. Weight measurements were taken weekly, and after 24 weeks of intervention, 24 mice from both groups were randomly selected and analyzed...
February 29, 2024: Sleep Medicine
https://read.qxmd.com/read/38530830/low-vitamin-d-levels-accelerates-muscle-mass-loss-in-patients-with-chronic-liver-disease
#17
JOURNAL ARTICLE
Tomomi Okubo, Masanori Atsukawa, Akihito Tsubota, Hiroki Ono, Tadamichi Kawano, Yuji Yoshida, Taeang Arai, Korenobou Hayama, Norio Itokawa, Chisa Kondo, Katsuhiko Iwakiri
Sarcopenia frequently and progressively occurs in patients with chronic liver disease. This study aimed to clarify the relationship between vitamin D levels and muscle mass loss. A total of 166 patients with chronic liver disease were enrolled in this study. Skeletal muscle mass index (SMI) was measured by bioelectrical impedance analysis at baseline and after 1 year. The rate of change in SMI from baseline after 1 year was calculated: ΔSMI (%) = [(1-year SMI - baseline SMI) / baseline SMI] × 100...
2024: PloS One
https://read.qxmd.com/read/38529894/understanding-primary-care-physician-perspectives-on-the-diagnosis-and-management-of-non-alcoholic-fatty-liver-disease-a-qualitative-study
#18
JOURNAL ARTICLE
Natalia I Heredia, Jemima C John, Sonia Singh, Jessica P Hwang, Larkin L Strong, Maya Balakrishnan, Lorna H McNeill
Primary care physicians (PCPs) are well suited to manage patients with non-alcoholic fatty liver disease (NAFLD), but the limited, existing research suggests inadequate knowledge about the natural history, diagnostic methods, and management of NAFLD. The purpose of this qualitative study is to further understand the knowledge and practices for the diagnosis and management of NAFLD among PCPs. We conducted in-depth interviews with PCPs in the Greater Houston area, addressing current clinical practices used for diagnosing and managing NAFLD, as well as the perceptions of the PCPs regarding the burden of NAFLD on patients...
2024: Inquiry: a Journal of Medical Care Organization, Provision and Financing
https://read.qxmd.com/read/38529849/paediatric-steatotic-liver-disease-has-unique-characteristics-%C3%A2-a-multisociety-statement-endorsing-the-new-nomenclature
#19
JOURNAL ARTICLE
Pietro Vajro
Nonalcoholic fatty liver disease (NAFLD) has been a commonly used term and diagnosis in paediatric hepatology, gastroenterology, and endocrinology clinics for over 30 years. A multisociety Delphi process has determined a new name "Steatotic Liver Disease" (SLD) as the overarching term for disorders associated with hepatic lipid accumulation. Our Societies give our support to steatotic liver disease as the best overarching term for use in our communities. Metabolic dysfunction-associated steatotic liver disease (MASLD) overcomes many of the shortcomings of the name NAFLD...
March 26, 2024: Journal of Pediatric Gastroenterology and Nutrition
https://read.qxmd.com/read/38528356/nonalcoholic-fatty-liver-disease-and-associated-risk-factors-in-obese-nigerians-a-cross-sectional-study
#20
JOURNAL ARTICLE
C P Onyia, P Asogwa, W Adiri, O Obienu, U N Ijoma, S C Nwokediuko, E N Okeke
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is now adjudged the most common liver disease in the world, contributing to the rising incidence of hepatocellular carcinoma worldwide. However, the true prevalence of nonalcoholic fatty liver disease among obese individuals and its contribution to the burden of liver disease in Nigeria is unknown. AIM: To determine the prevalence of nonalcoholic fatty liver disease and associated risk factors in obese subjects...
March 1, 2024: Nigerian Journal of Clinical Practice
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