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https://www.readbyqxmd.com/read/28748314/the-present-status-of-fecal-microbiota-transplantation-and-its-value-in-the-elderly
#1
REVIEW
Yao-Wen Cheng, Monika Fischer
OPINION STATEMENT: PURPOSE OF REVIEW: This article will review current literature describing fecal microbiota transplantation (FMT) in the treatment of various diseases, and its potential role in elderly patients (age ≥ 65 years). RECENT FINDINGS: Research on FMT has blossomed in the last decade and its pivotal role in the treatment of recurrent Clostridium difficile infection (CDI) has been recognized by the American College of Gastroenterology in the latest guidelines...
July 26, 2017: Current Treatment Options in Gastroenterology
https://www.readbyqxmd.com/read/28747917/upregulation-of-intestinal-barrier-function-in-mice-with-dss-induced-colitis-by-a-defined-bacterial-consortium-is-associated-with-expansion-of-il-17a-producing-gamma-delta-t-cells
#2
Ming Li, Bing Wang, Xiaotong Sun, Yan Tang, Xiaoqing Wei, Biying Ge, Yawei Tang, Ying Deng, Chunyang He, Jieli Yuan, Xia Li
Bacterial consortium transplantation (BCT) is a promising alternative to fecal microbiota transplantation in treating inflammatory bowel disease (IBD). Here, we showed that a defined bacterial consortium derived from healthy mice was able to enhance the intestinal barrier function of mice with dextran sulfate sodium (DSS)-induced colitis. Interestingly, we found that the bacterial consortium significantly promoted the expansion of IL-17A-producing γδT (γδT17) cells in colonic lamina propria, which was closely associated with changing of intestinal microbial composition...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28747556/markers-of-inflammation-and-influence-of-nitric-oxide-on-platelet-activation-in-the-course-of-ulcerative-colitis
#3
Beata Gawrońska, Joanna Matowicka-Karna, Maciej Kralisz, Halina Kemona
Ulcerative colitis is a non-specific inflammatory bowel disease of unknown etiology. We investigated whether severe form of ulcerative colitis may lead to increased number of platelets, changes in platelet parameters and their activation. To address our objectives, we measured concentrations of nitric oxide and markers of inflammation.We found increased number of low-volume platelets in a group of affected patients. However, their activity was not as high as expected. In addition to that we observed eight times higher concentration of nitric oxide in patients suffering from ulcerative colitis than in healthy individuals...
July 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28747340/epithelial-tnf-receptor-signaling-promotes-mucosal-repair-in-inflammatory-bowel-disease
#4
Emily M Bradford, Stacy H Ryu, Ajay Pal Singh, Goo Lee, Tatiana Goretsky, Preetika Sinh, David B Williams, Amber L Cloud, Elias Gounaris, Vihang Patel, Olivia F Lamping, Evan B Lynch, Mary Pat Moyer, Isabelle G De Plaen, David J Shealy, Guang-Yu Yang, Terrence A Barrett
TNF plays an integral role in inflammatory bowel disease (IBD), as evidenced by the dramatic therapeutic responses in Crohn's disease (CD) patients induced by chimeric anti-TNF mAbs. However, treatment of CD patients with etanercept, a decoy receptor that binds soluble TNF, fails to improve disease. To explore this discrepancy, we investigated the role of TNF signaling in Wnt/β-catenin-mediated intestinal stem cell and progenitor cell expansion in CD patients, human cells, and preclinical mouse models. We hypothesized that TNF exerts beneficial effects on intestinal epithelial cell (IEC) responses to injury...
July 26, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28747318/attention-and-memory-impairments-in-pediatric-patients-with-cystic-fibrosis-and-inflammatory-bowel-disease-in-comparison-to-healthy-controls
#5
Bartosz Piasecki, Maia Stanisławska-Kubiak, Wojciech Strzelecki, Ewa Mojs
The main aim of the study was to analyze and compare attention and memory performance in pediatric patients with cystic fibrosis (CF), inflammatory bowel disease (IBD) and in healthy controls. 28 patients with CF, 30 patients with IBD and 30 healthy subjects took part in the study (all in age range of 7-17). All subjects were in intellectual norm. To analyze the functioning of attention, the d2 Test of Attention by Brickenkamp (d2 test) was applied. Memory performance was assessed using the Benton Visual Retention Test (BVRT) and the Trial of 10 words...
July 26, 2017: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/28747220/a-novel-hand-assisted-laparoscopic-versus-conventional-laparoscopic-right-hemicolectomy-for-right-colon-cancer-study-protocol-for-a-randomized-controlled-trial
#6
Xuyang Yang, Qingbin Wu, Chengwu Jin, Wanbin He, Meng Wang, Tinghan Yang, Mingtian Wei, Xiangbing Deng, Wenjian Meng, Ziqiang Wang
BACKGROUND: Although conventional laparoscopic and hand-assisted laparoscopic surgery for colorectal cancer is widely used today, there remain many technical challenges especially for right colon cancer in obese patients. Herein, we develop a novel hand-assisted laparoscopic surgery (HALS) with complete mesocolic excision (CME), D3 lymphadenectomy, and a total "no-touch" isolation technique (HALS-CME) in right hemicolectomy to overcome these issues. According to previous clinic practice, this novel procedure is not only feasible and safe but has several technical merits...
July 26, 2017: Trials
https://www.readbyqxmd.com/read/28747057/prevalence-risk-factors-and-response-to-treatment-of-extra-intestinal-manifestations-in-patients-with-inflammatory-bowel-disease
#7
María Hernández-Tejero, Alicia Granja Navacerrada, Pilar Bernal Checa, Rubén Piqué Becerra, Alicia Algaba García, Iván Guerra Marina, Francisco Javier García-Alonso, Mariano Syed, Fernando Bermejo
INTRODUCTION: Patients with inflammatory bowel disease can experience extra-intestinal manifestations that may cause significant morbidity. AIMS: To describe the prevalence, characteristics, treatment and evolution of extra-intestinal manifestations in inflammatory bowel disease patients treated in our hospital and to identify associated risk factors. METHODS: This was a retrospective, observational, case-control study. All inflammatory bowel disease patients with extra-intestinal manifestations were considered as cases and inflammatory bowel disease patients without extra-intestinal manifestations were considered as controls...
July 27, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28747056/fecal-transplantation-as-a-treatment-for-clostridium-difficile-infection-in-patients-with-ulcerative-colitis
#8
Marta Izquierdo Romero, Pilar Varela Trastoy, Alejo Mancebo Mata
Clostridium difficile (CD) infection is currently the most frequent etiology of nosocomial diarrhea. Besides, its incidence is progressively increasing in ambulatory patients. Inflammatory bowel disease (IBD) is a risk factor of CD infection itself, but also due to the regular immunosuppressive treatment used in these patients. At the present time, fecal transplantation (FT) is a safe and cost-effective alternative if the previous antibiotic treatments have failed. Similar outcomes between patients with IBD and general population have been reported...
July 27, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28746225/ulcerative-colitis-with-acute-pleurisy-a-case-report-and-review-of-the-literature
#9
Shuming Lu, Lihua Wang, Weisheng Zhang, Zhuqing Zhang, Lina Liu, Yingde Wang, Hua Meng
RATIONALE: Inflammatory bowel diseases (IBD), including ulcerative colitis (UC) and Crohn's disease, are associated with a large number of extraintestinal manifestations. Pulmonary manifestations are infrequently seen in patients with IBD. Moreover, serositis including pleural and pericardial manifestations in UC is rare. PATIENT CONCERNS: We report a case of UC with acute pleurisy in a 43-year-old man; review literature; and discuss the diagnosis, differential diagnosis, and treatment...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28746114/differences-across-illness-perceptions-in-inflammatory-bowel-disease-and-their-relationships-to-psychological-distress-and-quality-of-life
#10
Davina Tribbick, Michael Salzberg, William Connell, Finlay Macrae, Michael Kamm, Glen Bates, Georgina Cunningham, David Austin, Simon Knowles
Patients with greater inflammatory bowel disease activity readily identify poorer psychosocial outcomes; however, the role of gender, disease type, and individual illness perceptions facets are less well known. This study aimed to characterize the role of illness perceptions, gender, and disease type on anxiety, depression, and quality of life. Eighty-one patients diagnosed with inflammatory bowel disease (39 men, mean age 35 years) attending a tertiary hospital outpatient clinic were studied. Questionnaires used included the Manitoba Index, the Brief Illness Perceptions Questionnaire, Hospital Anxiety and Depression Scale, and the World Health Organization Brief Quality of Life Scale...
July 2017: Gastroenterology Nursing: the Official Journal of the Society of Gastroenterology Nurses and Associates
https://www.readbyqxmd.com/read/28745812/neuronal-control-of-experimental-colitis-occurs-via-sympathetic-intestinal-innervation
#11
R A Willemze, O Welting, H P van Hamersveld, S L Meijer, J H A Folgering, H Darwinkel, J Witherington, A Sridhar, M J Vervoordeldonk, J Seppen, W J de Jonge
BACKGROUND: Vagus nerve stimulation is currently clinically evaluated as a treatment for inflammatory bowel disease. However, the mechanism by which this therapeutic intervention can have an immune-regulatory effect in colitis remains unclear. We determined the effect of intestine-specific vagotomy or intestine-specific sympathectomy of the superior mesenteric nerve (SMN) on dextran sodium sulfate (DSS)-induced colitis in mice. Furthermore, we tested the efficacy of therapeutic SMN stimulation to treat DSS-induced colitis in rats...
July 26, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28745410/short-and-medium-term-outcomes-following-primary-ileocaecal-resection-for-crohn-s-disease-in-two-specialist-centres
#12
A de Buck van Overstraeten, E J Eshuis, S Vermeire, G Van Assche, M Ferrante, G R D'Haens, C Y Ponsioen, A Belmans, C J Buskens, A M Wolthuis, W A Bemelman, A D'Hoore
BACKGROUND: Despite improvements in medical therapy, the majority of patients with Crohn's disease still require surgery. The aim of this study was to report safety, and clinical and surgical recurrence rates, including predictors of recurrence, after ileocaecal resection for Crohn's disease. METHODS: This was a cohort analysis of consecutive patients undergoing a first ileocaecal resection for Crohn's disease between 1998 and 2013 at one of two specialist centres...
July 26, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28744098/spotlight-on-brodalumab-in-the-treatment-of-moderate-to-severe-plaque-psoriasis-design-development-and-potential-place-in-therapy
#13
REVIEW
Michael Roman, Melvin W Chiu
Brodalumab is a novel fully human immunoglobulin G2 monoclonal antibody that antagonizes the interleukin (IL)-17 pathway by binding with high affinity to human IL-17RA. The role of IL-17A in the pathogenesis of psoriasis, as well as the remarkable effectiveness of IL-17 inhibitors in the treatment of moderate-to-severe plaque psoriasis, is well established. The mechanism of action of brodalumab is unique in that it inhibits the IL-17 receptor compared to the two other currently FDA-approved IL-17 inhibitors, secukinumab and ixekizumab, which inhibit the IL-17A molecule itself...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28743733/paediatric-inflammatory-bowel-disease-a-presenting-lesion
#14
David J McCreary, Guy Millman
No abstract text is available yet for this article.
July 25, 2017: Archives of Disease in Childhood. Education and Practice Edition
https://www.readbyqxmd.com/read/28743143/pitfalls-in-diagnosis-of-early-onset-inflammatory-bowel-disease
#15
Mariela Dore, Paloma Triana Junco, Alba Sánchez Galán, Gerardo Prieto, Esther Ramos, Martha Muñoz Romo, Manuel Gómez Cervantes, Francisco Hernández, Leopoldo Martínez, Manuel López Santamaría
No abstract text is available yet for this article.
July 25, 2017: European Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28742719/pediatric-gastroenterologists-approach-to-venous-thromboembolism-prophylaxis-in-pediatric-inflammatory-bowel-disease
#16
Kimberley Ann Chien, Hoda T Hammad, Linda Gerber, Sujit Sheth, Robbyn Sockolow, Nicole Elena Kucine
The risk of venous thromboembolism (VTE) is significantly increased in inflammatory bowel disease (IBD) patients. For the adult population, prophylaxis guidelines exist to help guide physicians in their management of high-risk IBD patients. While it is known that children with IBD also experience increased rates of VTE, there is no clear consensus on how best to prevent these unwanted complications. We sought to better understand practicing pediatric gastroenterologists' awareness of this issue and practices surrounding prevention of VTE in their pediatric patients...
July 22, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28742404/pregnane-x-receptor-polymorphisms-and-risk-of-inflammatory-bowel-disease-a-meta-analysis
#17
Xiaolan Guo, Ming Yan
BACKGROUND: Pregnane X receptor (PXR) gene polymorphisms have been widely studied in terms of the association with inflammatory bowel disease (IBD), with inconsistent results. OBJECTIVE: The present meta-analysis was performed to assess the association between PXR gene polymorphisms and the susceptibility of IBD, Crohn's disease (CD), and ulcerative colitis (UC). METHODS: PubMed, Wanfang, and CNKI databases were searched for eligible studies before November 1, 2016...
July 25, 2017: Immunological Investigations
https://www.readbyqxmd.com/read/28742273/protein-secondary-structure-analysis-of-dried-blood-serum-using-infrared-spectroscopy-to-identify-markers-for-colitis-screening
#18
Jitto Titus, Hemendra Ghimire, Emilie Viennois, Didier Merlin, A G Unil Perera
There remains a great need for diagnosis of inflammatory bowel disease (IBD), for which the current technique, colonoscopy, is costly and also has risks for complications. Attenuated Total Reflectance Fourier Transform Infrared (ATR-FTIR) spectroscopy is a new screening technique to evaluate colitis. Using second derivative spectral deconvolution of the absorbance spectra, a full set of spectral markers were identified based on statistical analysis. Using this method, Amide I group frequencies, (specifically, alpha helix to beta sheet ratio of the protein secondary structure) were identified in addition to the previously reported glucose and mannose signatures in sera of chronic and acute mice models of colitis...
July 25, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/28741645/inflammasome-and-autophagy-regulation-a-two-way-street
#19
Qian Sun, Jie Fan, Timothy R Billiar, Melanie J Scott
Inflammation plays a significant role in protecting hosts against pathogens. Inflammation induced by non-infectious, endogenous agents can be detrimental, and if excessive can result in organ and tissue damage. The inflammasome is a major innate immune pathway that can be activated via both exogenous pathogen-associated molecular patterns (PAMPs) and endogenous damage-associated molecular patterns (DAMPs). Inflammasome activation involves formation and oligomerization of a protein complex including a NOD-like receptor (NLR), an adaptor protein (ASC) and procaspase-1...
July 24, 2017: Molecular Medicine
https://www.readbyqxmd.com/read/28741616/rural-and-urban-residence-during-early-life-is-associated-with-a-lower-risk-of-inflammatory-bowel-disease-a-population-based-inception-and-birth-cohort-study
#20
Eric I Benchimol, Gilaad G Kaplan, Anthony R Otley, Geoffrey C Nguyen, Fox E Underwood, Astrid Guttmann, Jennifer L Jones, Beth K Potter, Christina A Catley, Zoann J Nugent, Yunsong Cui, Divine Tanyingoh, Nassim Mojaverian, Alain Bitton, Matthew W Carroll, Jennifer deBruyn, Trevor J B Dummer, Wael El-Matary, Anne M Griffiths, Kevan Jacobson, M Ellen Kuenzig, Desmond Leddin, Lisa M Lix, David R Mack, Sanjay K Murthy, Juan Nicolás Peña Sánchez, Harminder Singh, Laura E Targownik, Maria Vutcovici, Charles N Bernstein
OBJECTIVES: To determine the association between inflammatory bowel disease (IBD) and rural/urban household at the time of diagnosis, or within the first 5 years (y) of life. METHODS: Population-based cohorts of residents of four Canadian provinces were created using health administrative data. Rural/urban status was derived from postal codes based on population density and distance to metropolitan areas. Validated algorithms identified all incident IBD cases from administrative data (Alberta: 1999-2008, Manitoba and Ontario: 1999-2010, and Nova Scotia: 2000-2008)...
July 25, 2017: American Journal of Gastroenterology
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