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https://www.readbyqxmd.com/read/29233676/targeting-epigenome-with-dietary-nutrients-in-cancer-current-advances-and-future-challenges
#1
REVIEW
Mohammad Imran Khan, Suvasmita Rath, Vaqar Mustafa Adhami, Hasan Mukhtar
Tumorigenesis and epigenetic are closely linked with each other. Epigenetic changes are potential regulators of gene expression without involving any change in the DNA itself. More interestingly, epigenetic changes are reversible heritable changes which pass through generations. Many dietary bioactive ingredients regulate epigenetic control of cells and influence biochemical processes. Correlation between epigenetic regulation and cancer onset has been well established. Recent studies provide important information on the role of bioactive dietary components in cancer prevention and therapy...
December 9, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29204729/-nutrient-sensing-and-self-renewal-o-glcnac-in-a-new-role
#2
REVIEW
Nikita S Sharma, Ashok K Saluja, Sulagna Banerjee
Whether embryonic, hematopoietic or cancer stem cells, this metabolic reprogramming is dependent on the nutrient-status and bioenergetic pathways that is influenced by the micro-environmental niches like hypoxia. Thus, the microenvironment plays a vital role in determining the stem cell fate by inducing metabolic reprogramming. Under the influence of the microenvironment, like hypoxia, the stem cells have increased glucose and glutamine uptake which result in activation of hexosamine biosynthesis pathway (HBP) and increased O-GlcNAc Transferase (OGT)...
December 5, 2017: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/29204255/bariatric-surgery-and-long-term-nutritional-issues
#3
REVIEW
Roberta Lupoli, Erminia Lembo, Gennaro Saldalamacchia, Claudia Kesia Avola, Luigi Angrisani, Brunella Capaldo
Bariatric surgery is recognized as a highly effective therapy for obesity since it accomplishes sustained weight loss, reduction of obesity-related comorbidities and mortality, and improvement of quality of life. Overall, bariatric surgery is associated with a 42% reduction of the cardiovascular risk and 30% reduction of all-cause mortality. This review focuses on some nutritional consequences that can occur in bariatric patients that could potentially hinder the clinical benefits of this therapeutic option...
November 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/29185137/chlorophyll-fluorescence-as-a-tool-for-nutrient-status-identification-in-rapeseed-plants
#4
Hazem M Kalaji, Wojciech Bąba, Krzysztof Gediga, Vasilij Goltsev, Izabela A Samborska, Magdalena D Cetner, Stella Dimitrova, Urszula Piszcz, Krzysztof Bielecki, Kamila Karmowska, Kolyo Dankov, Agnieszka Kompała-Bąba
In natural conditions, plants growth and development depends on environmental conditions, including the availability of micro- and macroelements in the soil. Nutrient status should thus be examined not by establishing the effects of single nutrient deficiencies on the physiological state of the plant but by combinations of them. Differences in the nutrient content significantly affect the photochemical process of photosynthesis therefore playing a crucial role in plants growth and development. In this work, an attempt was made to find a connection between element content in (i) different soils, (ii) plant leaves, grown on these soils and (iii) changes in selected chlorophyll a fluorescence parameters, in order to find a method for early detection of plant stress resulting from the combination of nutrient status in natural conditions...
November 28, 2017: Photosynthesis Research
https://www.readbyqxmd.com/read/29160685/graphene-oxide-a-new-carrier-for-slow-release-of-plant-micronutrients
#5
Shervin Kabiri, Fien Degryse, Diana N H Tran, Rodrigo da Silva, Michael J McLaughlin, Dusan Losic
The environmental problems and low efficiency associated with conventional fertilizers provides an impetus to develop advanced fertilizers with slower release and better performances. Here we report of development of a new carrier platform based on graphene oxide (GO) sheets that can provide a high loading of plant micronutrients with controllable slow release. To prove this concept two micronutrients zinc (Zn) and copper (Cu) were used to load on GO sheets and hence formulate GO-based micronutrients fertilizer...
November 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29153855/changes-in-element-availability-induced-by-sterilization-in-heavy-metal-contaminated-substrates-a-comprehensive-study
#6
Thomas Krauße, Eileen Schütze, René Phieler, David Fürst, Dirk Merten, Georg Büchel, Erika Kothe
Microbiome analyses of soils and microcosm experiments depend on conditions that include sterilization in order to perform experimental manipulation of microbial communities. Still, they should represent conditions close to nature. When using metal contaminated soils, sterilization methods might alter metal availability. Here, four typical metal contaminated substrates were analyzed, representing different contamination histories and soil types. They included two very poor substrates, as they are often found at metal contaminated sites...
November 10, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29137491/characterization-of-biochemical-traits-of-dog-rose-rosa-canina-l-ecotypes-in-the-central-part-of-iran
#7
Milad Javanmard, Hossein Ali Asadi-Gharneh, Pejman Nikneshan
Dog rose (Rosa canina L.) is a wild native species in Iran, with a significant genetic diversity. This plant serves as a rich source of vitamin C, anthocyanins, phenolic contents and carotenoids. Rose hips have been used in several food products, as well as perfumery and cosmetics industries. In this research, we investigate biochemical characteristics of five dog rose ecotypes (Kopehjamshid, Zarneh, Miyankish, Aghcheh and Sadeghiyeh), that were collected from the central part of Iran (Isfahan province). Amounts of vitamin C, total carotenoids, total phenolic contents, total anthocyanins, macro and micro minerals were measured...
November 14, 2017: Natural Product Research
https://www.readbyqxmd.com/read/29132358/ftir-spectroscopy-as-a-unified-method-for-simultaneous-analysis-of-intra-and-extracellular-metabolites-in-high-throughput-screening-of-microbial-bioprocesses
#8
Gergely Kosa, Volha Shapaval, Achim Kohler, Boris Zimmermann
BACKGROUND: Analyses of substrate and metabolites are often bottleneck activities in high-throughput screening of microbial bioprocesses. We have assessed Fourier transform infrared spectroscopy (FTIR), in combination with high throughput micro-bioreactors and multivariate statistical analyses, for analysis of metabolites in high-throughput screening of microbial bioprocesses. In our previous study, we have demonstrated that high-throughput (HTS) FTIR can be used for estimating content and composition of intracellular metabolites, namely triglyceride accumulation in oleaginous filamentous fungi...
November 13, 2017: Microbial Cell Factories
https://www.readbyqxmd.com/read/29127920/uptake-and-phytotoxic-effect-of-benzalkonium-chlorides-in-lepidium-sativum-and-lactuca-sativa
#9
Adnan Hossain Khan, Mark Libby, Daniel Winnick, John Palmer, Mark Sumarah, Madhumita B Ray, Sheila M Macfie
Cationic surfactants such as benzalkonium chlorides (BACs) are used extensively as biocides in hospitals, food processing industries, and personal care products. BACs have the potential to reach the rooting zone of crop plants and BACs might thereby enter the food chain. The two most commonly used BACs, benzyl dimethyl dodecyl ammonium chloride (BDDA) and benzyl dimethyl tetradecyl ammonium chloride (BDTA), were tested in a hydroponic system to assess the uptake by and phytotoxicity to lettuce (Lactuca sativa L...
November 8, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/29123343/multiple-nutritional-deficiencies-in-cerebral-palsy-compounding-physical-and-functional-impairments
#10
P G Hariprasad, K E Elizabeth, Mathew J Valamparampil, D Kalpana, T S Anish
Introduction: Cerebral palsy (CP) refers to a spectrum of disorders causing physical and intellectual morbidity. Macro and micro nutrient deficiencies often contribute to the subnormal physical and mental capabilities of them. Objectives: To assess the growth, nutritional status, physical and functional ability and quality of life in cerebral palsy children and to determine any relation with their gross motor and functional capabilities. Method: The study was conducted at a Tertiary Care Centre, with the participants in the age group 1-16 years...
October 2017: Indian Journal of Palliative Care
https://www.readbyqxmd.com/read/29117450/nutrition-strategies-before-and-during-ultra-endurance-event-a-significant-gap-between-science-and-practice
#11
Soyzana K Papadopoulou, Eleni E Xyla, Spyridon Methenitis, Konstantinos G Feidantsis, Yiannis Kotsis, Ioannis G Pagkalos, Maria N Hassapidou
The purpose of the present study was to investigate and assess the nutritional practices of open-water swimmers, during the preparation period and the competition, as well as their implications on performance and anthropometric parameters according to their age. Twenty-four (n=24) men open-water swimmers, twelve young (26.3±4.9yrs) and twelve older athletes (45.8±9.7yrs), participated in the present study. Nutritional behavior - intake-energy consumption, and anthropometric characteristics were evaluated prior to the Toroneos Gulf crossing (26Km)...
November 8, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/29098563/melanization-affects-the-content-of-selected-elements-in-parmelioid-lichens
#12
Lorenzo Fortuna, Elena Baracchini, Gianpiero Adami, Mauro Tretiach
Lichens belonging to Parmeliaceae are highly diversified, but most of them share an extremely conserved morpho-chemical trait: the lower cortex is heavily melanized. The adaptive value of this character is still uncertain. Melanins are ubiquitous compounds found in most organisms since they fulfil several biological functions including defense against UV radiation, oxidizing agents, microbial stress, and metal complexation. This work aims to establish whether melanization can affect the elemental content of lichen thalli...
November 3, 2017: Journal of Chemical Ecology
https://www.readbyqxmd.com/read/29093710/malnutrition-modulator-of-immune-responses-in-tuberculosis
#13
REVIEW
Padmapriyadarsini Chandrasekaran, Natarajan Saravanan, Ramalingam Bethunaickan, Srikanth Tripathy
Nutrition plays a major role in the management of both acute and chronic diseases, in terms of body's response to the pathogenic organism. An array of nutrients like macro- and micro-nutrients, vitamins, etc., are associated with boosting the host's immune responses against intracellular pathogens including mycobacterium tuberculosis (M.tb). These nutrients have an immunomodulatory effects in controlling the infection and inflammation process and nutritional deficiency of any form, i.e., malnutrition may lead to nutritionally acquired immunodeficiency syndrome, which greatly increases an individual's susceptibility to progression of infection to disease...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29093533/the-emergent-rhizosphere-imaging-the-development-of-the-porous-architecture-at-the-root-soil-interface
#14
J R Helliwell, C J Sturrock, S Mairhofer, J Craigon, R W Ashton, A J Miller, W R Whalley, S J Mooney
The rhizosphere is the zone of soil influenced by a plant root and is critical for plant health and nutrient acquisition. All below ground resources must pass through this dynamic zone prior to their capture by plant roots. However, researching the undisturbed rhizosphere has proved very challenging. Here we compare the temporal changes to the intact rhizosphere pore structure during the emergence of a developing root system in different soils. High resolution X-ray Computed Tomography (CT) was used to quantify the impact of root development on soil structural change, at scales relevant to individual micro-pores and aggregates (µm)...
November 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29072117/investigation-of-phyco-remediation-of-road-salt-run-off-with-marine-microalgae-nannochloropsis-gaditana
#15
Roopa Devasya, Amarjeet Bassi
Phyco-remediation is an environmental friendly method, which involves the application of beneficial microalgae to treat wastewater-containing pollutants for a diverse range of conditions. Several industrial processes generate hyper saline wastewater, which is a significant challenge for conventional wastewater treatment, and the disposal of saline waters also has a significant negative impact on the environment. Road salt run-off is one such saline wastewater stream not currently treated and one that contributes significantly to negatively impacting receiving bodies of water...
October 26, 2017: Environmental Technology
https://www.readbyqxmd.com/read/29058657/nitrogen-regulator-glnr-directly-controls-transcription-of-genes-encoding-lysine-deacetylases-in-actinobacteria
#16
Ying Xu, Di You, Bang-Ce Ye
N-Lysine acetylation is a dynamic, reversible and regulatory post-translational modification (PTM) in prokaryotes, which integrates and coordinates metabolisms responding to environmental clues. However, the molecular mechanism underlying the signalling pathway from nutrient sensing to protein acetylation remains incompletely understood in micro-organisms. Here we found that global nitrogen regulator GlnR directly controls transcription of genes encoding lysine deacetylases in Actinobacteria. Electrophoretic mobility shift assays and real-time PCR (RT-PCR) in three Actinobacteria species (Saccharopolyspora erythraea, Streptomyces coelicolor and Mycobacterium smegmatis) revealed that GlnR regulator protein is able to interact with the promoter regions of these genes and activate their transcription...
October 23, 2017: Microbiology
https://www.readbyqxmd.com/read/29058531/biophysical-and-computational-comparison-on-the-binding-affinity-of-three-important-nutrients-to-%C3%AE-lactoglobulin-folic-acid-ascorbic-acid-and-vitamin-k3
#17
Somaye Shahraki, Ali Heydari, Maryam Saeidifar, Masoumeh Gomroki
Small globular protein, β-lactoglobulin (βLG), which has significant affinity toward many drugs, is the most abundant whey protein in milk. In this study, the interaction of βLG with three important nutrients, ascorbic acid (ASC), folic acid (FOL) and vitamin K3 (VK3) was investigated by spectroscopic methods (UV-visible and fluorescence) along with molecular docking technique. The results of fluorescence measurements showed that studied nutrients strongly quenched βLG fluorescence in static (FOL and ACS) or static-dynamic combined quenching (VK3) mode...
October 23, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29057875/organic-coating-on-biochar-explains-its-nutrient-retention-and-stimulation-of-soil-fertility
#18
Nikolas Hagemann, Stephen Joseph, Hans-Peter Schmidt, Claudia I Kammann, Johannes Harter, Thomas Borch, Robert B Young, Krisztina Varga, Sarasadat Taherymoosavi, K Wade Elliott, Amy McKenna, Mihaela Albu, Claudia Mayrhofer, Martin Obst, Pellegrino Conte, Alba Dieguez-Alonso, Silvia Orsetti, Edisson Subdiaga, Sebastian Behrens, Andreas Kappler
Amending soil with biochar (pyrolized biomass) is suggested as a globally applicable approach to address climate change and soil degradation by carbon sequestration, reducing soil-borne greenhouse-gas emissions and increasing soil nutrient retention. Biochar was shown to promote plant growth, especially when combined with nutrient-rich organic matter, e.g., co-composted biochar. Plant growth promotion was explained by slow release of nutrients, although a mechanistic understanding of nutrient storage in biochar is missing...
October 20, 2017: Nature Communications
https://www.readbyqxmd.com/read/29049338/growing-plants-on-oily-nutrient-poor-soil-using-a-native-symbiotic-fungus
#19
Timothy S Repas, D Michael Gillis, Zakia Boubakir, Xiaohui Bao, Gary J Samuels, Susan G W Kaminskyj
The roots of land plants associate with microbes, including fungal symbionts that can confer abiotic stress tolerance. Bitumen extraction following oil-sand surface mining in the Athabasca region of Alberta, Canada removes plant nutrients but leaves a petrochemical residue, making the coarse tailings (CT) hostile to both plants and microbes. We isolated an endophyte strain of the Ascomycete Trichoderma harzianum we call TSTh20-1 (hereafter, TSTh) from a dandelion that was naturally growing on CT. TSTh colonization allowed tomato, wheat, and remediation seed mixtures to germinate and their seedlings to flourish on CT without the use of fertilizer...
2017: PloS One
https://www.readbyqxmd.com/read/29046572/nutrient-dependent-growth-underpinned-the-ediacaran-transition-to-large-body-size
#20
Jennifer F Hoyal Cuthill, Simon Conway Morris
Macroscale rangeomorph fossils, with characteristic branching fronds, appear (571 Myr ago) after the Gaskiers glaciation (580 Myr ago). However, biological mechanisms of size growth and potential connections to ocean geochemistry were untested. Using micro-computerized tomography and photographic measurements, alongside mathematical and computer models, we demonstrate that growth of rangeomorph branch internodes declined as their relative surface area decreased. This suggests that frond size and shape were directly responsive to nutrient uptake...
August 2017: Nature Ecology & Evolution
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