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https://www.readbyqxmd.com/read/29224324/-clinical-analysis-of-lung-transplantation-in-eight-patients-with-obstructive-bronchiolitis-syndrome-after-hematopoietic-stem-cell-transplantation
#1
L L Wang, H Y Wang, Y F Shen, M Z Lu, J Y Chen, B Wu
Objective: To investigate the efficacy and prognosis of lung transplantation (LT) for end-stage bronchiolitis obliterans syndrome (BOS) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) . Methods: The clinical data of eight cases with end-stage BOS after allo-HSCT who were treated by LT in our hospital were retrospectively analyzed. Results: Eight patients with hematological malignancy underwent allo-HSCT, and the median age was 23 (12-40) years. The donors are parents or siblings. Severe BOS occurred in 8 patients after allo-HSCT, the median age for LT was 27...
November 14, 2017: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/29178963/chloral-hydrate-enteral-infusion-for-sedation-in-ventilated-children-the-chosen-pilot-study
#2
Ari R Joffe, Jessica Hogan, Cathy Sheppard, Gerda Tawfik, Jonathan P Duff, Gonzalo Garcia Guerra
BACKGROUND: We aimed to test a novel method of delivery of chloral hydrate (CH) sedation in ventilated critically ill young children. METHODS: Children < 12 years old, within 72 hours of admission, who were ventilated, receiving enteral tube-feeds, with intermittent CH ordered were enrolled after signed consent. Patients received a CH loading-dose of 10 mg/kg enterally, then a syringe-pump enteral infusion at 5 mg/kg/hour, increasing to a maximum of 9 mg/kg/hour...
November 26, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29178284/nitric-oxide-inhalations-in-bronchiolitis-a-pilot-randomized-double-blinded-controlled-trial
#3
Asher Tal, David Greenberg, Yossef Av-Gay, Inbal Golan-Tripto, Yael Feinstein, Shalom Ben-Shimol, Ron Dagan, Aviv D Goldbart
AIM: The aims of this pilot study were to determine safety, tolerability (primary outcome) and efficacy (secondary outcome) of high-dose inhaled nitric oxide for the treatment of infants with moderately severe bronchiolitis. METHODS: This was a pilot, double-blinded, randomized controlled study (phase IIa). Intermittent inhalations of nitric oxide 160 ppm for 30 min or oxygen/air (control) were given 5 times/day to hospitalized infants (2-11 months) with acute bronchiolitis...
November 27, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29170350/53%C3%A2-piloting-patch-providing-assessment-and-treatment-for-children-at-home-and-piecing-together-what-works
#4
Caroline Ward, Katie Knight, Mary-Rose Ballard, Georgina Keogh, Miriam Samuel, Sara Buttle, Claire Robb, Francesca Cleugh
AIMS: PATCH is a pilot acute community children's nurse led service delivering assessment and treatment for children at home who are moderately unwell and might otherwise be admitted to hospital or attend Paediatric Emergency Department (PED). Children are referred by PED or GP and followed up via telephone support and home visits depending on clinical need for duration of acute illness. METHODS: Pilot year funded by Imperial Charity. Using evaluation to build business case for sustained commissioned service...
December 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/29159901/severe-stevens-johnson-syndrome-toxic-epidermal-necrolysis-overlap-syndrome-beyond-skin-involvement
#5
Tiago Milheiro Silva, João Farela Neves, Ana Casimiro, Luís Varandas, Catarina Gouveia
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but serious dermatologic diseases with many potential multisystem complications. We describe the case of an 8-year-old girl who developed severe SJS/TEN overlap syndrome (25% of her body surface area was affected) complicated by pancreatitis and bronchiolitis obliterans. These rare complications emphasize the need for careful, intensive monitoring of possible complications and an interdisciplinary team approach to provide optimal treatment and follow-up...
November 21, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/29158779/the-treatment-of-acute-bronchiolitis-past-present-and-future
#6
Laura Petrarca, Tiago Jacinto, Raffaella Nenna
Acute bronchiolitis treatment: little has changed from late 19th century to nowadays, promising strategies incoming http://ow.ly/BmH230aWoXr.
March 2017: Breathe
https://www.readbyqxmd.com/read/29137182/current-and-prospective-protein-biomarkers-of-lung-cancer
#7
REVIEW
Tatiana N Zamay, Galina S Zamay, Olga S Kolovskaya, Ruslan A Zukov, Marina M Petrova, Ana Gargaun, Maxim V Berezovski, Anna S Kichkailo
Lung cancer is a malignant lung tumor with various histological variants that arise from different cell types, such as bronchial epithelium, bronchioles, alveoli, or bronchial mucous glands. The clinical course and treatment efficacy of lung cancer depends on the histological variant of the tumor. Therefore, accurate identification of the histological type of cancer and respective protein biomarkers is crucial for adequate therapy. Due to the great diversity in the molecular-biological features of lung cancer histological types, detection is impossible without knowledge of the nature and origin of malignant cells, which release certain protein biomarkers into the bloodstream...
November 13, 2017: Cancers
https://www.readbyqxmd.com/read/29119812/the-nursing-assessment-of-infants-with-bronchiolitis
#8
Clare Davies, Donna Waters, Andrea Marshall
Bronchiolitis is the leading cause of morbidity and hospitalization in infants under the age of one year. Supportive treatments and regular assessment remain the mainstay of care for infants admitted to hospital. Nurses play an important role in the assessment of infants with bronchiolitis; however, this is not well described in the literature and consequently little is known about what strategies nurses employ in assessing infants with bronchiolitis. The aim of this study was to explore bronchiolitis assessment in the context of nursing practice...
June 2017: Journal of Child Health Care: for Professionals Working with Children in the Hospital and Community
https://www.readbyqxmd.com/read/29110800/long-term-outcomes-and-management-of-lung-transplant-recipients
#9
REVIEW
Joseph Costa, Luke J Benvenuto, Joshua R Sonett
Lung transplantation is an established treatment for patients with end-stage lung disease. Improvements in immunosuppression and therapeutic management of infections have resulted in improved long-term survival and a decline in allograft rejection. Allograft rejection continues to be a serious complication following lung transplantation, thereby leading to acute graft failure and, subsequently, chronic lung allograft dysfunction (CLAD). Bronchiolitis obliterans syndrome (BOS), the most common phenotype of CLAD, is the leading cause of late mortality and morbidity in lung recipients, with 50% having developed BOS within 5 years of lung transplantation...
June 2017: Best Practice & Research. Clinical Anaesthesiology
https://www.readbyqxmd.com/read/29108516/clinical-outcomes-of-paramyxovirus-infections-in-lung-transplant-recipients-treated-with-oral-ribavirin-a-two-center-case-series
#10
Bryan Garcia, Nirmal Sharma, Kevin Johnson, Juan Salgado, Keith Wille
OBJECTIVES: Paramyxoviruses contribute to morbidity and mortality after lung transplant and are associated with bronchiolitis obliterans syndrome. Oral ribavirin has been used off-label for treatment of paramyxoviruses in immunosuppressed patients; however, data supporting its use for this purpose are lacking. MATERIALS AND METHODS: We conducted a retrospective review to evaluate clinical outcomes of lung transplant recipients infected with paramyxoviruses and received treatment with oral ribavirin at 2 tertiary referral centers...
October 31, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29080051/reducing-unnecessary-chest-x-rays-antibiotics-and-bronchodilators-through-implementation-of-the-nice-bronchiolitis-guideline
#11
Richard Breakell, Benjamin Thorndyke, Julie Clennett, Christian Harkensee
Chest X-rays (CXR), antibiotics and inhaled/nebulized therapy are overused in bronchiolitis, despite evidence-based guidelines suggesting supportive management only. This study investigates the effect of the implementation of the NICE bronchiolitis guideline in a secondary paediatric unit in England. We present a quality improvement project with a completed audit cycle (winter 2014-2015 and 2015-2016) pre- and post-implementation of the NICE bronchiolitis guideline. The educational intervention included sessions for raising awareness of appropriate and inappropriate management of bronchiolitis for both clinicians and nursing staff...
October 28, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29076616/benefits-of-the-humidified-low-flow-oxygen-therapy-in-infants-with-mild-moderate-bronchiolitis
#12
Sonia Lorente, Rebeca Gimeno, Josep Maria Losilla, Sandra Garzón, Jaume Vives
BACKGROUND: There is no evidence to support the use of humidification in low-flow oxygen therapy as a usual clinical practice in the management of bronchiolitis. AIMS AND OBJECTIVES: To investigate the clinical benefits of using humidification in low-flow oxygen therapy. Specific objectives were to investigate via an assessment of the number of nasal lavages whether humidification can help to decrease the nasal mucus viscosity, to determine whether it can relieve feeding difficulties by comparing the weight gain in infants, to ascertain whether it can relieve respiratory distress by assessing the heart and respiratory rates and contribute to improved clinical outcomes, measured by the length of stay and oxygen requirements DESIGN: A controlled quasi-experimental study...
October 27, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29073753/lithium-intoxication-a-possible-interaction-with-moxifloxacin
#13
Selvi Kayipmaz, Ali Ercan Altınöz, Nadide Elmas Gülcü Ok
Lithium is a well-known treatment for patients with mood disorders. Intoxication by lithium may be lethal particularly in elderly due to altered pharmacokinetics, renal impairment or multiple drug use. We presented a 74-year-old female patient who had been stabile with lithium carbonate 600 mg/day for 5 years and developed lithium intoxication after bronchiolitis. She presented with altered mental status. The neurological signs resolved slowly after lithium and moxifloxacin were stopped immediately and fluid resuscitation administered...
November 30, 2017: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29071966/-effects-of-moxibustion-at-feishu-bl-13-and-shenshu-bl-23-on-peripheral-blood-t-cells-and-serum-interleukin-in-asthmatic-rats
#14
Xiang-Hua Chen, Hai-Ming He
OBJECTIVE: To observe the effect of moxibustion at "Feishu" (BL 13) and "Shenshu"(BL 23) on peripheral blood T cells and serum interleukin in rats with asthma, so as to explore its immunological mechanisms in relieving asthma. METHODS: Thirty SD rats were randomly divided into normal, model and moxibustion groups(10 rats/group). Asthma model was established by intraperitoneal injection of ovalbumin and aluminum hydroxide, and ovalbumin inhalation. Moxibustion was applied to bilateral "Feishu" (BL 13) and "Shenshu"(BL 23) for 30 min, once daily for 14 d...
April 25, 2017: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/29071730/transforming-growth-factor-%C3%AE-enhances-rho-kinase-activity-and-contraction-in-airway-smooth-muscle-via-the-nucleotide-exchange-factor-arhgef1
#15
Yasin Shaifta, Charles E MacKay, Nneka Irechukwu, Katie A O'Brien, David B Wright, Jeremy P T Ward, Greg A Knock
Transforming growth factor-β (TGF-β), RhoA/Rho-kinase and Src-family kinases (SrcFK) have independently been implicated in airway hyper-responsiveness, but how they interact in order to regulate airway smooth muscle contractility is not fully understood. We found that TGF-β pre-treatment enhanced acute contractile responses to bradykinin (BK) in isolated rat bronchioles, and inhibitors of RhoGEFs (Y16) and Rho-kinase (Y27632), but not the SrcFK inhibitor PP2 prevented this enhancement. In cultured human airway smooth muscle cells (hASMC), TGF-β pre-treatment enhanced the protein expression of the Rho guanine nucleotide exchange factor ARHGEF1, MLC20 , MYPT-1 and the actin-severing protein cofilin, but not of RhoA, ROCK2 or c-Src...
October 25, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/29070533/international-variation-in-asthma-and-bronchiolitis-guidelines
#16
Leigh Anne Bakel, Jemila Hamid, Joycelyne Ewusie, Kai Liu, Joseph Mussa, Sharon Straus, Patricia Parkin, Eyal Cohen
BACKGROUND AND OBJECTIVES: Guideline recommendations for the same clinical condition may vary. The purpose of this study was to determine the degree of agreement among comparable asthma and bronchiolitis treatment recommendations from guidelines. METHODS: National and international guidelines were searched by using guideline databases (eg, National Guidelines Clearinghouse: December 16-17, 2014, and January 9, 2015). Guideline recommendations were categorized as (1) recommend, (2) optionally recommend, (3) abstain from recommending, (4) recommend against a treatment, and (5) not addressed by the guideline...
November 2017: Pediatrics
https://www.readbyqxmd.com/read/29048473/use-of-taurolidine-in-lung-transplantation-for-cystic-fibrosis-and-impact-on-bacterial-colonization
#17
Mohamed Zeriouh, Anton Sabashnikov, Nikhil P Patil, Bastian Schmack, Barlomiej Zych, Prashant N Mohite, Diana García Sáez, Achim Koch, Ashham Mansur, Simona Soresi, Alexander Weymann, Nandor Marczin, Thorsten Wahlers, Fabio De Robertis, André Rüdiger Simon, Aron-Frederik Popov
OBJECTIVES: The presence of bacterial colonization that causes chronic pulmonary infections in cystic fibrosis (CF) patients remains a key issue before lung transplantation. We sought to assess the impact of intraoperative taurolidine lavage on bacterial colonization and long-term outcomes following lung transplantation in CF patients. METHODS: Between 2007 and 2013, 114 CF patients underwent lung transplantation at our institute, and taurolidine 2% bronchial lavage was applied in a substantial proportion of patients (n = 42)...
October 18, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28988958/mycobacterium-abscessus-and-massiliense-lung-infection-during-macrolide-treatment-for-bronchiolitis-obliterans-after-allogeneic-hematopoietic-stem-cell-transplantation
#18
Noriko Miyake, Yong Chong, Ruriko Nishida, Katsuto Takenaka, Koji Kato, Toshihiro Miyamoto, Akio Aono, Akiko Takaki, Satoshi Mitarai, Shinji Shimoda, Nobuyuki Shimono, Koichi Akashi
In patients undergoing allogeneic hematopoietic stem cell transplantation (allo-SCT), post-transplant lung infection is critical for their prognosis. Mycobacterium abscessus complex is not fully recognized as a nontuberculous mycobacteria (NTM) pathogen of post-SCT lung infection. Here, we present three post-allogeneic SCT patients who developed pulmonary infection caused by M. abscessus complex including M. abscessus and M. massiliense. In all three cases, macrolide antibiotics had been administered for bronchiolitis obliterans syndrome (BOS) before the confirmation of their infection, and macrolide resistance was noted in the M...
October 5, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28987320/lung-development-regeneration-and-plasticity-from-disease-physiopathology-to-drug-design-using-induced-pluripotent-stem-cells
#19
REVIEW
Engi Ahmed, Caroline Sansac, Said Assou, Delphine Gras, Aurélie Petit, Isabelle Vachier, Pascal Chanez, John De Vos, Arnaud Bourdin
Lungs have a complex structure composed of different cell types that form approximately 17 million airway branches of gas-delivering bronchioles connected to 500 million gas-exchanging alveoli. Airways and alveoli are lined by epithelial cells that display a low rate of turnover at steady-state, but can regenerate the epithelium in response to injuries. Here, we review the key points of lung development, homeostasis and epithelial cell plasticity in response to injury and disease, because this knowledge is required to develop new lung disease treatments...
October 4, 2017: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28987219/role-of-viral-infections-in-the-development-and-exacerbation-of-asthma-in-children
#20
REVIEW
Tuomas Jartti, James E Gern
Viral infections are closely linked to wheezing illnesses in children of all ages. Respiratory syncytial virus (RSV) is the main causative agent of bronchiolitis, whereas rhinovirus (RV) is most commonly detected in wheezing children thereafter. Severe respiratory illness induced by either of these viruses is associated with subsequent development of asthma, and the risk is greatest for young children who wheeze with RV infections. Whether viral illnesses actually cause asthma is the subject of intense debate...
October 2017: Journal of Allergy and Clinical Immunology
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