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https://www.readbyqxmd.com/read/28822959/na2s-a-fast-releasing-h2s-donor-given-as-suppository-lowers-blood-pressure-in-rats
#1
Lenka Tomasova, Adrian Drapala, Halina Jurkowska, Maria Wróbel, Marcin Ufnal
BACKGROUND: Hydrogen sulfide (H2S) is involved in blood pressure control. The available slow-releasing H2S-donors are poorly soluble in water and their ability to release H2S in biologically relevant amounts under physiological conditions is questionable. Therefore, new slow-releasing donors or new experimental approaches to fast-releasing H2S donors are needed. METHODS: Hemodynamics and ECG were recorded in male, anesthetized Wistar Kyoto rats (WKY) and in Spontaneously hypertensive rats (SHR) at baseline and after: 1) intravenous (iv) infusion of vehicle or Na2S; 2) administration of vehicle suppositories or Na2S suppositories...
April 19, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28822689/cholesterol-lowering-gene-therapy-counteracts-the-development-of-non-ischemic-cardiomyopathy-in-mice
#2
Ilayaraja Muthuramu, Ruhul Amin, Andrey Postnov, Mudit Mishra, Joseph Pierre Aboumsallem, Tom Dresselaers, Uwe Himmelreich, Paul P Van Veldhoven, Olivier Gheysens, Frank Jacobs, Bart De Geest
A causal role of hypercholesterolemia in non-ischemic heart failure has never been demonstrated. Adeno-associated viral serotype 8 (AAV8)-low-density lipoprotein receptor (AAV8-LDLr) gene transfer was performed in LDLr-deficient mice without and with pressure overload induced by transverse aortic constriction (TAC). AAV8-LDLr gene therapy resulted in an 82.8% (p < 0.0001) reduction of plasma cholesterol compared with controls. Mortality rate was lower (p < 0.05) in AAV8-LDLr TAC mice compared with control TAC mice (hazard ratio for mortality 0...
August 1, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28822516/comparison-of-yoga-and-walking-exercise-on-cardiac-time-intervals-as-a-measure-of-cardiac-function-in-elderly-with-increased-pulse-pressure
#3
Satish Gurunathrao Patil, Shankargouda S Patil, Manjunatha R Aithala, Kusal Kanti Das
OBJECTIVE: Arterial aging along with increased blood pressure(BP) has become the major cardiovascular(CV) risk in elderly. The aim of the study was to compare the effects of yoga program and walking-exercise on cardiac function in elderly with increased pulse pressure (PP). METHODS: An open label, parallel-group randomized controlled study design was adopted. Elderly individuals aged ≥60 years with PP≥60mmHg were recruited for the study. Yoga (study) group (n=30) was assigned for yoga training and walking (exercise) group (n=30) for walking with loosening practices for one hour in the morning for 6days in a week for 3 months...
July 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/28822509/prevalence-and-control-of-cardiovascular-risk-factors-in-stable-coronary-artery-outpatients-in-india-compared-with-the-rest-of-the-world-an-analysis-from-international-clarify-registry
#4
Upendra KauL, Subramaniam Natrajan, Jamshed Dalal, Ram Kirti Saran
OBJECTIVES: We describe the clinical characteristics, prevalence and control of coronary artery disease (CAD) risk factors of the Indian cohort enrolled in the CLARIFY registry and compare them with data from rest of the world (ROW). METHODS: CLARIFY is an international, prospective, observational, longitudinal cohort study in stable CAD outpatients. The baseline data of Indian cohort (n=709) were compared to ROW (n=31994). RESULTS: The CLARIFY India patients were significantly younger than the ROW (59...
July 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/28822384/clinical-characteristics-of-trauma-patients-requiring-hydrocortisone-treatment-for-refractory-hypotension
#5
Gina Kim, Jeffrey Young
Corticosteroids play an important role in responding to physiologic stress in the human body. However, its application in critical care remains heavily debated. The purpose of this study was to identify patient characteristics associated with receiving stress-dose steroids during the intensive care unit stay after traumatic injury and its effect on in-hospital mortality. Patients admitted to the University of Virginia trauma center between January 1, 2011, and December 31, 2015, were identified using our Trauma Registry...
August 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28821541/targeting-mir-423-5p-reverses-exercise-training-induced-hcn4-channel-remodeling-and-sinus-bradycardia
#6
Alicia D'Souza, Charles M Pearman, Yanwen Wang, Shu Nakao, Sunil Jit R Logantha, Charlotte Cox, Hayley J Bennett, Yu Zhang, Anne Berit Johnsen, Nora Linscheid, Pi C Poulsen, Jonathan Elliott, Jessica Coulson, Jamie S McPhee, Abigail C Robertson, Paula A da Costa Martins, Ashraf Kitmitto, Ulrik Wisloff, Elizabeth J Cartwright, Oliver Monfredi, Alicia Lundby, Halina Dobrzynski, Delvac Oceandy, Gwilym M Morris, Mark R Boyett
Rationale: Downregulation of the pacemaking ion channel, HCN4, and the corresponding ionic current, If, underlies exercise training-induced sinus bradycardia in rodents. If this occurs in humans, it could explain the increased incidence of bradyarrhythmias in veteran athletes and it will be important to understand the underlying processes. Objective: To test the role of HCN4 in the training-induced bradycardia in human athletes and investigate the role of micro-RNAs (miRs) in the repression of HCN4. Methods and Results: As in rodents, the intrinsic heart rate was significantly lower in human athletes than non-athletes and in all subjects the rate-lowering effect of the HCN selective blocker, ivabradine, was significantly correlated with the intrinsic heart rate, consistent with HCN repression in athletes...
August 17, 2017: Circulation Research
https://www.readbyqxmd.com/read/28821499/primary-ventricular-tachycardia-in-paediatric-population-in-a-tertiary-centre
#7
Shuenn-Nan Chiu, Wei-Lun Wu, Chun-Wei Lu, Wei-Chieh Tseng, Kun-Lang Wu, Jou-Kou Wang, Mei-Hwan Wu
OBJECTIVE: To delineate the outcome of ventricular tachycardia (VT) in the paediatric population. METHODS: Patients who developed sustained VT between the ages of 0 and 18 years in a referral centre from 1991 to 2015 were enrolled. RESULTS: A total of 116 patients (67 male/49 female) had documented VT, and 53 (46%) had associated heart disease, namely cardiomyopathy in 20 (17%), structural heart disease in 19 (16%) and channelopathy in 14 (12%), and some of them presented with two types of associated heart disease...
August 18, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28820855/resistance-exercise-order-does-not-affect-the-magnitude-and-duration-of-post-exercise-blood-pressure-in-older-women
#8
Crisieli M Tomeleri, João Pedro Nunes, Mariana F Souza, Aline Gerage, Alexandre Marcori, Kessi Cassiane Iarosz, Crivaldo Gomes Cardoso-Júnior, Edilson S Cyrino
The aim of this study was to compare the effects of two resistance exercise order on post-exercise blood pressure (BP) in trained, non-hypertensive older women. Sixteen women (68.3 ± 3.3 years, 63.5 ± 11.6 kg, 157.5 ± 5.1 cm) performed two sessions witheight exercises (3 sets of 8-12 repetitions) in distinct orders (from multi- to single-joint exercises [MS] or from single- to multi-joint exercises [SM]) and a control session, without exercise. Blood pressure and heart rate were obtained pre and post-sessions (60 min)...
August 15, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28819055/temperature-effects-on-the-cardiorespiratory-control-of-american-bullfrog-tadpoles-based-on-a-non-invasive-methodology
#9
Leonardo S Longhini, Lucas A Zena, Glauber S F da Silva, Kênia C Bícego, Luciane H Gargaglioni
Temperature effects on cardiac autonomic tonus in amphibian larval stages have never been investigated. Therefore, we evaluated the effect of different temperatures (15°C, 25°C, and 30°C) on the cardiorespiratory rates and cardiac autonomic tonus of premetamorphic bullfrog tadpoles, Lithobates catesbeianus To this end, a non-invasive method was developed to permit measurements of electrocardiogram (ECG) and buccal movements (fB ; surface electromyography of the buccal floor). For evaluation of autonomic regulation, intraperitoneal injections of Ringer's solution (control), atropine (cholinergic muscarinic antagonist), and sotalol (β-adrenergic antagonist) were performed...
August 17, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28819005/blood-pressure-and-leg-deoxygenation-are-exaggerated-during-treadmill-walking-in-patients-with-peripheral-artery-disease
#10
Amanda J Miller, J Carter Luck, Danielle Jin-Kwang Kim, Urs A Leuenberger, David N Proctor, Lawrence I Sinoway, Matthew D Muller
The purpose of this study was to investigate blood pressure (BP) and leg skeletal muscle oxygen saturation (SmO2) during treadmill walking in patients with peripheral artery disease (PAD) and healthy subjects. Eight PAD patients (66 ± 3 years, 1 female) and eight healthy subjects (65 ± 2 years, 1 female) walked on a treadmill at 2 miles/hour. The incline increased by 2% every 2 minutes from 0% to 15% or until maximal discomfort. BP was measured every 2 min with an auscultatory cuff. Heart rate (HR) was recorded continuously with an electrocardiogram...
August 17, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28817856/back-to-basics-the-effect-of-healthy-diet-and-exercise-on-chronic-disease-management
#11
Robert L Allison
INTRODUCTION: The increase in obesity rates in the U.S. and other less developed industrial countries have led to a worldwide epidemic of chronic disease states. Increased obesity rates are implicated in the treatment failures for illnesses such as coronary artery disease, diabetes, heart failure, hypertension and cancer. Effective prevention of obesity through diet and exercise contributes to the successful medical management of multiple chronic disease states. OBJECTIVE: Review the last 10 years of literature (2006-2016) on the effects of diet and exercise as they relate to the prevention of chronic disease...
2017: South Dakota Medicine: the Journal of the South Dakota State Medical Association
https://www.readbyqxmd.com/read/28817701/effect-of-exoskeletal-joint-constraint-and-passive-resistance-on-metabolic-energy-expenditure-implications-for-walking-in-paraplegia
#12
Sarah R Chang, Rudi Kobetic, Ronald J Triolo
An important consideration in the design of a practical system to restore walking in individuals with spinal cord injury is to minimize metabolic energy demand on the user. In this study, the effects of exoskeletal constraints on metabolic energy expenditure were evaluated in able-bodied volunteers to gain insight into the demands of walking with a hybrid neuroprosthesis after paralysis. The exoskeleton had a hydraulic mechanism to reciprocally couple hip flexion and extension, unlocked hydraulic stance controlled knee mechanisms, and ankles fixed at neutral by ankle-foot orthoses...
2017: PloS One
https://www.readbyqxmd.com/read/28817494/nocturnal-hypertension-and-right-heart-remodeling
#13
Marijana Tadic, Cesare Cuspidi, Vera Celic, Biljana Pencic-Popovic, Giuseppe Mancia
BACKGROUND: We sought to investigate right ventricular (RV) and right atrial mechanics in patients with daytime, night-time and daytime-night-time hypertension. METHODS: This cross-sectional study included 256 untreated patients who underwent 24-h ambulatory blood pressure monitoring and complete echocardiographic examination including strain analysis. Night-time hypertension was defined as nocturnal SBP at least 120 mmHg and/or DBP at least 70 mmHg and daytime hypertension as SBP at least 135 mmHg and/or DBP at least 85 mmHg...
August 16, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28816881/the-shikani-optical-stylet-as-an-alternative-to-awake-fiberoptic-intubation-in-patients-at-risk-of-secondary-cervical-spine-injury-a-randomized-controlled-trial
#14
Rabab S S Mahrous, Aly M M Ahmed
BACKGROUND: Conventional intubation of the trachea and consequent prone positioning of anesthetized patients with cervical spine instability may result in secondary neurological injury. Historically, flexible fiberoptics used to be the chief choice for patients presenting with cervical spine instability surgery with difficult airway. Recently, the rigid optical stylets have shown promise in assisting difficult intubations. PURPOSE: The aim of the present study was to compare the efficacy of Shikani optical stylet (SOS) with the flexible fiberscope for awake intubation in patients with cervical spine instability...
August 14, 2017: Journal of Neurosurgical Anesthesiology
https://www.readbyqxmd.com/read/28816745/restoration-of-normal-sympathetic-neural-function-in-heart-failure-following-baroreflex-activation-therapy-final-43-month-study-report
#15
Raffaella Dell'Oro, Edoardo Gronda, Gino Seravalle, Giuseppe Costantino, Luca Alberti, Barbara Baronio, Tiziana Staine, Emilio Vanoli, Giuseppe Mancia, Guido Grassi
BACKGROUND: Baroreflex activation therapy (BAT) exerts in severe heart failure sympathoinhibitory effects, improving clinical variables and reducing hospitalization rate. The current follow-up study was aimed at determining the long-term effects of BAT, assessing whether BAT in heart failure allows to restore physiological levels of sympathetic function. METHODS: Seven patients out of the 11 heart failure patients aged 66.5 ± 3 years (mean ± SEM) in New York Heart Association Class III with left ventricular ejection fraction 40% or less and impaired functional capacity recruited in the study survived at the final follow-up (43...
August 14, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28816352/pulmonary-artery-wave-propagation-and-reservoir-function-in-conscious-man-impact-of-pulmonary-vascular-disease-respiration-and-dynamic-stress-tests
#16
Junjing Su, Charlotte Manisty, Ulf Simonsen, Luke S Howard, Kim H Parker, Alun D Hughes
Detailed hemodynamic analysis may provide novel insights into the pulmonary circulation. Therefore, wave intensity and reservoir-excess pressure analyses were applied in the pulmonary artery to characterise changes in wave propagation and reservoir function during spontaneous respiration and dynamic stress tests. Right heart catheterisation was performed using a pressure and Doppler flow sensor tipped guidewire to obtain simultaneous pressure and flow velocity measurements in the pulmonary artery in control subjects and patients with pulmonary arterial hypertension (PAH) at rest...
August 17, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28816207/evaluation-of-the-effects-of-various-sound-pressure-levels-on-the-level-of-serum-aldosterone-concentration-in-rats
#17
Parvin Nassiri, Sajad Zare, Mohammad R Monazzam, Akram Pourbakht, Kamal Azam, Taghi Golmohammadi
INTRODUCTION: Noise exposure may have anatomical, nonauditory, and auditory influences. Considering nonauditory impacts, noise exposure can cause alterations in the automatic nervous system, including increased pulse rates, heightened blood pressure, and abnormal secretion of hormones. The present study aimed at examining the effect of various sound pressure levels (SPLs) on the serum aldosterone level among rats. MATERIALS AND METHODS: A total of 45 adult male rats with an age range of 3 to 4 months and a weight of 200 ± 50 g were randomly divided into 15 groups of three...
July 2017: Noise & Health
https://www.readbyqxmd.com/read/28816118/paroxysmal-sympathetic-hyperactivity-the-storm-after-acute-brain-injury
#18
REVIEW
Geert Meyfroidt, Ian J Baguley, David K Menon
A substantial minority of patients who survive an acquired brain injury develop a state of sympathetic hyperactivity that can persist for weeks or months, consisting of periodic episodes of increased heart rate and blood pressure, sweating, hyperthermia, and motor posturing, often in response to external stimuli. The unifying term for the syndrome-paroxysmal sympathetic hyperactivity (PSH)-and clear diagnostic criteria defined by expert consensus were only recently established. PSH has predominantly been described after traumatic brain injury (TBI), in which it is associated with worse outcomes...
September 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28815936/combinatorial-effect-of-nicotine-and-black-tea-on-heart-rate-variability-useful-or-harmful
#19
S Joukar, M Sheibani
The effect of nicotine on heart rate variability (HRV) is controversial. Autonomic nervous system is the main regulator of heart rhythm, and heart rate variability is an appropriate index to assessment of the effects of the autonomic system on heart. In this study, the combination effect of nicotine and black tea consumption on sympatho-vagal balance and heart rate variability was investigated in rats. Male Wistar rats were randomized into four groups as control, tea (2.5 g/100 cc, daily), nicotine (2 mg/kg/d) and tea plus nicotine groups which treated for 28 days, and in the 29th day, their electrocardiograms (lead II) were recorded...
June 2017: Autonomic & Autacoid Pharmacology
https://www.readbyqxmd.com/read/28814785/comparison-between-spectral-analysis-and-symbolic-dynamics-for-heart-rate-variability-analysis-in-the-rat
#20
Luiz Eduardo Virgilio Silva, Victor Rezende Geraldini, Bianca Potratz de Oliveira, Carlos Alberto Aguiar Silva, Alberto Porta, Rubens Fazan
Spectral analysis of heart rate (HR) has been widely used to assess the autonomic cardiovascular control. A nonlinear approach, known as symbolic analysis, has been reported to be very useful to assess the autonomic control of cardiovascular system in humans, but very few studies reported on the differences between these two approaches on experimental models. Two distinct approaches were used to elicit autonomic changes in conscious Wistar rats: (1) pharmacological blockade of cardiac autonomic receptors with atenolol (ATE, N = 9) or methylatropine (ATR, N = 9) and (2) mild changes in arterial pressure (AP) induced by phenylephrine (PHE, N = 9) or sodium nitroprusside (NPS, N = 9)...
August 16, 2017: Scientific Reports
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