keyword
https://read.qxmd.com/read/38045455/landiolol-an-intravenous-%C3%AE-1-selective-blocker-is-useful-for-dissociating-a-fusion-of-atrial-activation-via-accessory-pathway-and-atrioventricular-node
#1
JOURNAL ARTICLE
Takahiko Kinjo, Masaomi Kimura, Noriyoshi Kaname, Daisuke Horiuchi, Taihei Itoh, Yuji Ishida, Kimitaka Nishizaki, Yuichi Toyama, Shingo Sasaki, Hirofumi Tomita
INTRODUCTION: During ventricular pacing, a fusion of atrial activation may occur owing to the simultaneous retrograde conduction of the atrioventricular (AV) node and accessory pathway (AP), potentially leading to an inaccurate mapping of the atrial AP insertion site. OBJECTIVE: We tested the hypothesis that landiolol, an ultra-short-acting intravenous β1-blocker, could dissociate a fusion of atrial activation. METHODS: We conducted a prospective before-and-after study to investigate the effect of landiolol on retrograde conduction via the AV node and AP...
December 2023: Journal of Arrhythmia
https://read.qxmd.com/read/37917331/landiolol-for-the-prevention-of-postoperative-atrial-fibrillation-after-cardiac-surgery-a-systematic-review-and-meta-analysis
#2
REVIEW
Teresa Cafaro, Melissa Allwood, William F McIntyre, Lily J Park, Julian Daza, Sandra N Ofori, Michael Ke Wang, Flavia K Borges, David Conen, Maura Marcucci, Jeff S Healey, Richard P Whitlock, Andre Lamy, Emilie P Belley-Côté, Jessica D Spence, Michael McGillion, P J Devereaux
PURPOSE: Postoperative atrial fibrillation (POAF) is a common complication following cardiac surgery. Although the evidence suggests that beta blockers prevent POAF, they often cause hypotension. Landiolol, an ultra-short-acting β1 blocker, may prevent POAF, without adverse hemodynamic consequences. SOURCE: We searched MEDLINE, CENTRAL, Embase, and trial registries between January 1970 and March 2022. We included randomized controlled trials (RCTs) that evaluated the effect of landiolol for the prevention of POAF after cardiac surgery...
November 2023: Canadian Journal of Anaesthesia
https://read.qxmd.com/read/37844977/haemodynamic-effects-of-acute-intravenous-landiolol-in-takotsubo-cardiomyopathy-with-dynamic-left-ventricular-outflow-tract-obstruction
#3
JOURNAL ARTICLE
YeJi Cho, Kenji Inoue, Mitsuhiro Kunimoto, Tohru Minamino
Takotsubo cardiomyopathy (TCM) leads to serious left ventricular outflow tract (LVOT) obstruction with cardiogenic shock in 6%-20% of cases. The onset of LVOT obstruction, coupled with mitral regurgitation resulting from systolic anterior motion of mitral valve leaflets, can lead to haemodynamic instability in addition to severely impaired systolic function. We describe three patients who experienced chest discomfort following emotional stress. These patients displayed pronounced abnormalities on ECGs, insignificant obstructive coronary disease and haemodynamic instability due to LVOT obstruction...
October 16, 2023: BMJ Case Reports
https://read.qxmd.com/read/37799246/comparing-the-incidence-of-propranolol-and-esmolol-related-cardiac-arrest-in-patients-with-thyroid-storm-a-systematic-literature-review
#4
REVIEW
Shadin Afifi, Vineet Suryadevara, Yaman Habab, Alana Hutcheson, Binay K Panjiyar, Gershon G Davydov, Hiba Nashat, Sally Ghali, Safeera Khan
A precarious complication of thyrotoxicosis, or thyroid storm, is the increased risk of cardiomyopathy, which leads to circulatory collapse and cardiopulmonary arrest. It is crucial to promptly identify this condition to prevent significant deterioration of the left ventricular function and cardiogenic shock. This article seeks to examine published research that emphasizes the connection between thyroid storm and beta-blocker usage in relation to cardiogenic collapse and provides management recommendations...
September 2023: Curēus
https://read.qxmd.com/read/37469535/ivabradine-effects-in-hospitalized-acute-heart-failure-patients-a-single-center-retrospective-study
#5
JOURNAL ARTICLE
Mahmoud Abdelnabi, Juthipong Benjanuwattra, Yehia Saleh, Haitham Badran, Shadi Ahmed, Abdallah Almaghraby
BACKGROUND: An increased heart rate (HR) is deleterious in patients with decompensated heart failure. Ivabradine, an HR lowering agent which acts by inhibiting the If current in the sinoatrial node, is indicated for chronic heart failure with reduced ejection fraction. However, data regarding the safety and efficacy of ivabradine in acute decompensated heart failure is limited. This retrospective observational study aimed to investigate the effects of ivabradine on morbidity and short-term mortality of hospitalized patients with acute decompensated heart failure...
2023: American Journal of Cardiovascular Disease
https://read.qxmd.com/read/37457790/digoxin-for-the-management-of-unstable-paroxysmal-supraventricular-tachycardia-in-a-patient-who-refused-electrical-cardioversion-in-a-rural-hospital
#6
Belayneh Dessie Kassa, Mekbib Amede, Mollalign Wubante, Mebratu Libanos, Kumlachew Geta
BACKGROUND: The most frequent atrioventricular tachycardia in the emergency room is atrioventricular nodal reentrant tachycardia (AVNRT). The first treatment option for ending stable narrow QRS complex SVTs is vagal maneuvers and adenosine. When adenosine or vagal maneuvers fail to change a patient's rhythm to normal sinus rhythm, long-acting AV nodal-blocking medications, including nondihydropyridine calcium channel blockers (verapamil and diltiazem), flecainide, or beta-blockers, are employed...
2023: Case Reports in Emergency Medicine
https://read.qxmd.com/read/37451701/bisoprolol-versus-celiprolol-on-dynamic-hyperinflation-cardiopulmonary-exercise-and-domiciliary-safety-in-copd-a-single-centre-randomised-crossover-study
#7
JOURNAL ARTICLE
William Anderson, Philip Short, Rose Ross, Brian J Lipworth
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is frequently associated with cardiovascular disease. The utility of beta-blockers for treating patients with COPD may be beneficial, but their safety remains uncertain, including worsening of dynamic hyperinflation (DH) during exercise. We hypothesised that among cardioselective beta-blockers celiprolol, due to its partial beta-2 agonist activity, may be safer than bisoprolol on exercise DH. METHODS: We measured isotime inspiratory capacity (IC) during cycle endurance testing in eleven moderate-severe COPD subjects, alongside other non-invasive cardiopulmonary exercise, bioreactance cardiac output, pulmonary function, biomarkers and daily domiciliary measures...
July 2023: BMJ Open Respiratory Research
https://read.qxmd.com/read/36960263/esmolol-is-not-the-solution-thyroid-storm-with-atrial-fibrillation
#8
Zaid N Herzallah, Shreya Gupta, Maryam D Abdulhamid, Omar Q Muhammed Noori
Thyroid storm is a challenging medical emergency that requires urgent assessment and management in a timely manner. In this article, we report on a case of a 37-year-old female who presented to the emergency department with a thyroid storm complicated by atrial fibrillation (AF) with a rapid ventricular response with no clinical signs of heart failure. As part of her medical management to rate control her AF, she was started on an infusion of a short-acting beta blocker, esmolol, and shortly after, she developed cardiac arrest...
February 2023: Curēus
https://read.qxmd.com/read/36294365/mitral-valve-systolic-anterior-motion-in-robotic-thoracic-surgery-as-the-cause-of-unexplained-hemodynamic-shock-from-a-case-report-to-recommendations
#9
Fabrizio Monaco, Filippo D'Amico, Gaia Barucco, Margherita Licheri, Pierluigi Novellis, Paola Ciriaco, Giulia Veronesi
Robotic major lung resection for lung cancer carries a risk for intraoperative hemodynamic instability. Systolic anterior motion (SAM) of the mitral valve is a rare and often misrecognized cause of intraoperative hemodynamic instability. If not promptly recognized, SAM leads to a complicated perioperative course. Here, we report for the first time a case of a patient with SAM with a severe degree of left ventricular outflow obstruction (LVOTO) undergoing robotic lung lobectomy and its challenging intraoperative management...
October 13, 2022: Journal of Clinical Medicine
https://read.qxmd.com/read/36245145/novel-topical-esmolol-hydrochloride-galnobax-for-diabetic-foot-wound-phase-1-2-multicenter-randomized-double-blind-vehicle-controlled-parallel-group-study
#10
RANDOMIZED CONTROLLED TRIAL
Ashu Rastogi, Sudhir A Kulkarni, Supreet K Deshpande, Vickie Driver, Hemanga Barman, Arun Bal, Manisha Deshmukh, Harikrishna Nair
We aimed to assess safety and dose-finding efficacy of esmolol hydrochloride (Galnobax) for healing of diabetic foot ulcer (DFU). This is phase 1/2 multicenter, randomized, double-blind vehicle-controlled study. Participants having diabetes and noninfected, full-thickness, neuropathic, grade I or II (Wagner classification) DFU, area 1.5-10 cm2 , and unresponsive to standard wound care (at least 4 weeks) were randomized to receive topical Galnobax 14% twice daily (BID), Galnobax 20% BID, Galnobax 20% once daily (OD)+vehicle, or vehicle BID with standard of care...
August 2023: Advances in Wound Care
https://read.qxmd.com/read/35842897/efficacy-and-safety-of-ivabradine-in-combination-with-beta-blockers-in-patients-with-stable-angina-pectoris-a-systematic-review-and-meta-analysis
#11
JOURNAL ARTICLE
Alexander Nedoshivin, Parvoleta T S Petrova, Yuri Karpov
INTRODUCTION: Beta-blockers are recommended by the European Society of Cardiology as first-line antianginal therapy for reducing heart rate (HR) and symptoms in patients with chronic coronary syndrome, despite a lack of data showing superiority to other antianginal agents. Most patients with angina pectoris require combination therapy to manage symptoms, with a second-line agent chosen to manage the predominant cardiovascular problem. Ivabradine, a selective sinus node If channel inhibitor shown to reduce HR and protect against anginal symptoms, has previously demonstrated noninferior anti-ischaemic and antianginal efficacy to beta-blockers...
September 2022: Advances in Therapy
https://read.qxmd.com/read/35706899/short-acting-intravenous-beta-blocker-as-a-first-line-of-treatment-for-atrial-fibrillation-after-cardiac-surgery-a-prospective-observational-study
#12
JOURNAL ARTICLE
X Chapalain, J F Oilleau, L Henaff, P Lorillon PharmD, D Le Saout, P Kha, K Pluchon, E Bezon, O Huet
Post-operative atrial fibrillation (POAF) defined as a new-onset of atrial fibrillation (AF) following surgery occurs frequently after cardiac surgery. For non-symptomatic patients, rate control strategy seems to be as effective as rhythm control one in surgical patients. Landiolol is a new highly cardio-selective beta-blocker agent with interesting pharmacological properties that may have some interest in this clinical situation. This is a prospective, monocentric, observational study. All consecutive adult patients (age >18 years old) admitted in the intensive care unit following cardiac surgery with a diagnosed episode of AF were eligible...
June 2022: European Heart Journal Supplements: Journal of the European Society of Cardiology
https://read.qxmd.com/read/35706898/benefits-and-safety-of-landiolol-for-rapid-rate-control-in-patients-with-atrial-tachyarrhythmias-and-acute-decompensated-heart-failure
#13
JOURNAL ARTICLE
Tsuyoshi Shiga
Atrial tachyarrhythmias often occur in patients with worsening heart failure (HF), and the development of atrial tachyarrhythmias in acute decompensated HF (ADHF) causes an uncontrolled heart rate (HR) and leads to further exacerbation of HF and persistence of a decompensated HF state. Landiolol, a short-acting intravenous beta-1 blocker, shows very high cardiac beta-1 selectivity and has a very short elimination half-life of approximately 4 min. As shown in several reports, the benefit of intravenous landiolol is that it lowers the ventricular rate early after the start of use without markedly deteriorating haemodynamics...
June 2022: European Heart Journal Supplements: Journal of the European Society of Cardiology
https://read.qxmd.com/read/35706896/landiolol-for-refractory-tachyarrhythmias-in-the-intensive-care-unit-case-reports
#14
JOURNAL ARTICLE
Clemens Gangl, Konstantin A Krychtiuk, Robert Schoenbauer, Walter S Speidl
Tachyarrhythmias are common complications of critically ill patients treated on intensive care units. Landiolol is an ultra-short acting beta-blocker with a very high beta1-selectivity. Therefore, landiolol effectively reduces heart rate with only minimal negative effects on blood pressure and inotropy. This article describes two cases of successful treatment of supraventricular and ventricular tachycardias with landiolol in critically ill patients.
June 2022: European Heart Journal Supplements: Journal of the European Society of Cardiology
https://read.qxmd.com/read/35706895/acute-rate-control-in-atrial-fibrillation-an-urgent-need-for-the-clinician
#15
JOURNAL ARTICLE
Gheorghe-Andrei Dan, Anca R Dan, Andreea Ivanescu, Adrian C Buzea
Rate and rhythm control are still considered equivalent strategies for symptom control using the Atrial Fibrillation Better Care algorithm recommended by the recent atrial fibrillation guideline. In acute situations or critically ill patients, a personalized approach should be used for rapid rhythm or rate control. Even though electrical cardioversion is generally indicated in haemodynamically unstable patients or for rapid effective rhythm control in critically ill patients, this is not always possible due to the high percentage of failure or relapses in such patients...
June 2022: European Heart Journal Supplements: Journal of the European Society of Cardiology
https://read.qxmd.com/read/35337743/effects-of-landiolol-on-macrocirculatory-parameters-and-left-and-right-ventricular-performances-following-cardiac-surgery-a-randomized-controlled-trial
#16
JOURNAL ARTICLE
Arnaud Ferraris, Matthias Jacquet-Lagrèze, Laure Cazenave, William Fornier, Wajma Jalalzai, Nicolas Rousseau-Saine, Matteo Pozzi, Jean-Luc Fellahi
OBJECTIVES: Postoperative atrial fibrillation (POAF) is a major complication after cardiac surgery, and an early postoperative introduction of beta-blockers is recommended to reduce its incidence. Landiolol, a new intravenous short-acting beta-1 blocker, could present a useful and safe macrohemodynamic profile after cardiac surgery. Detailed metabolic and hemodynamic effects of landiolol on cardiac performance, however, remain poorly documented. The authors aimed to investigate the dose-dependent hemodynamic and metabolic effects of landiolol in that specific setting...
February 14, 2022: Journal of Cardiothoracic and Vascular Anesthesia
https://read.qxmd.com/read/35094619/psychometric-properties-and-predictive-validity-of-the-pp-act
#17
JOURNAL ARTICLE
James A Shepperd, Gregory D Webster, Gabrielle C Pogge, David Fedele, Sreekala Prabhakaran, Jean Hunleth, Erika A Waters
OBJECTIVE: The Parent Proxy Asthma Control Test (PP-ACT) is a self-report measure of asthma control completed by caregivers on behalf of a child. We examined the psychometric properties and the reliability and predictive validity of the PP-ACT. METHODS: We conducted two studies (one cross-sectional, one longitudinal over three months) that surveyed caregivers ( N  = 1622) of children with asthma. Caregivers completed the PP-ACT and a variety of other measures, including child health outcomes...
January 2023: Journal of Asthma
https://read.qxmd.com/read/34962097/effect-of-landiolol-in-patients-with-tachyarrhythmias-and-acute-decompensated-heart-failure-adhf-a-case-series
#18
Valentina Ditali, Laura Garatti, Nuccia Morici, Luca Villanova, Claudia Colombo, Fabrizio Oliva, Alice Sacco
Tachycardia and rapid tachyarrhythmias are common in acute clinical settings and may hasten the deterioration of haemodynamics in patients with acute decompensated heart failure (ADHF), treated with inotropes. The concomitant use of a short-acting β1-selective beta-blocker, such as landiolol, could rapidly and safely restore an adequate heart rate without any negative inotropic effect. We present a case series of five patients with left ventricular dysfunction, admitted to our Intensive Cardiac Care Unit with ADHF deteriorated to cardiogenic shock, treated with a combination of landiolol and inotropes...
February 2022: ESC Heart Failure
https://read.qxmd.com/read/34952825/cardioprotective-effect-of-the-short-acting-beta-blocker-esmolol-in-experimental-ischemia-reperfusion
#19
Jorge Nuche, Sergio Huertas, Carlos Galán-Arriola, Pedro López-Ayala, Manuel Lobo, Borja Ibáñez
No abstract text is available yet for this article.
December 21, 2021: Revista Española de Cardiología
https://read.qxmd.com/read/34838902/successful-use-of-intravenous-b-blocker-therapy-in-cardiogenic-shock-supported-with-venoarterial-extracorporeal-membrane-oxygenation-a-case-series
#20
REVIEW
Alaa Rahhal, Amr Salah Omar, Amer Aljundi, Mohamed Kasem, Ahmed Mahfouz, Sumaya Alyafei
Tachycardia in cardiogenic shock (CS) might reduce the cardiac output (CO) by decreasing the ventricular filling time. Nevertheless, heart rate (HR) control with agents that possess negative inotropy might decrease the CO. Therefore, controlling the tachycardia in the setting of CS remains controversial. We herein describe four cases of patients presenting with myocardial infarction complicated with CS that required rescue venoarterial extracorporeal membrane oxygenation (VA-ECMO) initiation. Tachycardia was present with HR ∼130-140 beats per minute after VA-ECMO initiation, and hence esmolol was infused continuously at a starting dose of 10-20 mcg/kg/min and titrated according to HR...
November 25, 2021: Current Problems in Cardiology
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