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https://www.readbyqxmd.com/read/29791321/innovative-multi-site-photoplethysmography-measurement-and-analysis-demonstrating-increased-arterial-stiffness-in-paediatric-heart-transplant-recipients
#1
Emma J Sharkey, Costanzo Di Maria, Annette Klinge, Alan Murray, Dingchang Zheng, John O'Sullivan, John Allen
OBJECTIVE: It has been documented that heart transplantation in children is often complicated by arterial hypertension and increased arterial stiffness. AIM: to use innovative multi-site photoplethysmography (MPPG) pulse measurement and analysis technology to assess arterial stiffness change in paediatric heart transplant recipients (HTR) in comparison with healthy control (HC) children. 
 
 Approach: 20 heart transplant (median age 13.5 years old) (8 male) recipients were compared to an overall age- and gender-matched group of 161 healthy controls (11...
May 23, 2018: Physiological Measurement
https://www.readbyqxmd.com/read/29768360/clinical-efficacy-of-xenon-versus-propofol-a-systematic-review-and-meta-analysis
#2
Yimeng Xia, Hongwei Fang, Jindong Xu, Chenfei Jia, Guorong Tao, Buwei Yu
BACKGROUND: Interest in the anesthetic use of xenon, a noble gas, has waxed and waned for decades, and the clinical effects of xenon are still debated. We performed a meta-analysis to compare the clinical efficacy of xenon with that of propofol. METHODS: Electronic searches were performed through December 2017 using various databases, including PubMed, Embase, and the Cochrane Library. We identified thirteen trials that included a total of 817 patients. RESULTS: Patients treated with xenon had a lower bispectral index (BIS) (weighted mean difference (WMD): -6...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29761224/cardiopulmonary-factors-affecting-6-min-walk-distance-in-patients-with-idiopathic-inflammatory-myopathies
#3
Naoki Mugii, Fujiko Someya
Idiopathic inflammatory myopathies involve skeletal muscles and can be associated with interstitial lung disease and/or heart dysfunction, which may reduce exercise capacity. We aimed to clarify cardiopulmonary factors affecting the 6-min walk distance in patients who were able to walk without leg pain or fatigue. Twenty-three patients with inactive adult idiopathic inflammatory myopathies, and 18 age- and gender-matched healthy controls were evaluated for hemodynamic responses using noninvasive impedance cardiography during the 6-min walk test...
May 14, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29753421/nonlinear-analyses-of-heart-rate-variability-in-hypertension
#4
B K Koichubekov, M A Sorokina, Y M Laryushina, L G Turgunova, I V Korshukov
OBJECTIVE: The autonomic nervous system plays an important role in blood pressure regulation and in the development of hypertension. Heart rate variability (HRV) may be of importance in identifying subjects at higher risk of developing hypertension. In the present study, comparative analysis of HRV for normal and hypertension subjects using nonlinear indices has been carried out. PATIENTS AND METHODS: We analyzed the data from 24 patients with essential hypertension aged 45-55 (HG)...
May 9, 2018: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/29751583/blood-pressure-lowering-effect-of-cuban-policosanol-is-accompanied-by-improvement-of-hepatic-inflammation-lipoprotein-profile-and-hdl-quality-in-spontaneously-hypertensive-rats
#5
Kyung-Hyun Cho, Dhananjay Yadav, Suk-Jeong Kim, Jae-Ryong Kim
We investigated the antihypertensive effect of policosanol on spontaneously hypertensive rats (SHR). For this, we analyzed blood pressure, blood lipid, and lipoprotein properties in male SHR after consumption of Cuban policosanol (PCO). The experimental groups were as follows: normotensive Wistar Kyoto (WKY) control, SHR group fed normal diet (ND), SHR group fed 20 mg of PCO, SHR group fed 100 mg of PCO, and SHR group fed 200 mg of PCO per kg of body weight. After eight weeks, the SHR control group showed gradual increases up to 21% in systolic blood pressure (SBP) and diastolic blood pressure (DBP) compared with values at week 0...
May 3, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29750873/the-effect-of-superoxide-dismutase-sod-enzyme-inhibition-on-renal-microcirculation-of-spontaneously-hypertensive-stroke-prone-shrsp-and-wistar-rats
#6
A F Ahmeda, M G Rae, L M Anweigi, M F Al Otaibi, A A Al-Masri, E J Johns
A significant factor in the development of hypertension may be excessive vasoconstriction within the renal medulla. This study therefore investigated the role of superoxide dismutase (SOD) in the regulation of renal medullary and cortical blood perfusion (MBP and CBP respectively) in both stroke-prone spontaneously hypertensive rats (SHRSP) and normotensive Wistar rats. CBP and MBP were measured before and after intra-renal infusion of the SOD inhibitor, diethyldithio-carbamic acid (DETC). Under basal conditions, mean arterial pressure was significantly greater in SHRSP than Wistar rats, but both MBP and heart rate (HR) were significantly lower in SHRSP relative to Wistar rats (P < 0...
May 10, 2018: Physiological Research
https://www.readbyqxmd.com/read/29750475/effects-of-losartan-and-allopurinol-on-cardiorespiratory-regulation-in-obstructive-sleep-apnoea
#7
Barbara J Morgan, Mihaela Teodorescu, David F Pegelow, Emily R Jackson, Devin L Schneider, David T Plante, James P Gapinski, Scott J Hetzel, John M Dopp
Chemoreflex sensitization produced by chronic intermittent hypoxia (CIH) in rats is attenuated by angiotensin II type 1 receptor (AT1 R) blockade. AT1 R blockade and xanthine oxidase inhibition both ameliorate CIH-induced endothelial dysfunction. We hypothesized treatment with losartan and allopurinol would reduce chemoreflex sensitivity and improve hypoxic vasodilation in patients with obstructive sleep apnoea (OSA). Eighty-six hypertensive patients with apnoea-hypopnoea index ≥25 events/hr and no other cardiovascular, pulmonary, renal, or metabolic disease were randomly assigned to receive allopurinol, losartan, or placebo for 6 weeks...
May 11, 2018: Experimental Physiology
https://www.readbyqxmd.com/read/29740334/autonomic-differentiation-map-a-novel-statistical-tool-for-interpretation-of-heart-rate-variability
#8
Daniela Lucini, Nadia Solaro, Massimo Pagani
In spite of the large body of evidence suggesting Heart Rate Variability (HRV) alone or combined with blood pressure variability (providing an estimate of baroreflex gain) as a useful technique to assess the autonomic regulation of the cardiovascular system, there is still an ongoing debate about methodology, interpretation, and clinical applications. In the present investigation, we hypothesize that non-parametric and multivariate exploratory statistical manipulation of HRV data could provide a novel informational tool useful to differentiate normal controls from clinical groups, such as athletes, or subjects affected by obesity, hypertension, or stress...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29735689/wireless-intraoral-hybrid-electronics-for-real-time-quantification-of-sodium-intake-toward-hypertension-management
#9
Yongkuk Lee, Connor Howe, Saswat Mishra, Dong Sup Lee, Musa Mahmood, Matthew Piper, Youngbin Kim, Katie Tieu, Hun-Soo Byun, James P Coffey, Mahdis Shayan, Youngjae Chun, Richard M Costanzo, Woon-Hong Yeo
Recent wearable devices offer portable monitoring of biopotentials, heart rate, or physical activity, allowing for active management of human health and wellness. Such systems can be inserted in the oral cavity for measuring food intake in regard to controlling eating behavior, directly related to diseases such as hypertension, diabetes, and obesity. However, existing devices using plastic circuit boards and rigid sensors are not ideal for oral insertion. A user-comfortable system for the oral cavity requires an ultrathin, low-profile, and soft electronic platform along with miniaturized sensors...
May 7, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29733225/effects-of-the-right-carotid-sinus-compression-technique-on-blood-pressure-and-heart-rate-in-medicated-patients-with-hypertension
#10
Angélica María Campón-Checkroun, Agustín Luceño-Mardones, Inmaculada Riquelme, Jesús Oliva-Pascual-Vaca, François Ricard, Ángel Oliva-Pascual-Vaca
OBJECTIVES: To identify the immediate and middle-term effects of the right carotid sinus compression technique on blood pressure and heart rate in hypertensive patients. DESIGN: Randomized blinded experimental study. SETTINGS: Primary health centers of Cáceres (Spain). SUBJECTS: Sixty-four medicated patients with hypertension were randomly assigned to an intervention group (n = 33) or to a control group (n = 31)...
May 7, 2018: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/29723237/association-of-maternal-nutrition-with-transient-neonatal-hyperinsulinism
#11
Mathilde Louvigne, Stephanie Rouleau, Emmanuelle Caldagues, Isabelle Souto, Yanis Montcho, Audrey Migraine Bouvagnet, Olivier Baud, Jean Claude Carel, Geraldine Gascoin, Regis Coutant
OBJECTIVE: The objective was to determine whether maternal nutritional factors are associated with transient neonatal hyperinsulinism (HI). DESIGN AND SETTING: Case control study in 4 French tertiary Obstetrics and Neonatology Departments between 2008 and 2015. METHODS: Sixty-seven mothers of neonates diagnosed with transient hyperinsulinism and 113 mothers of controls were included. The screening for hyperinsulinemic hypoglycemia in neonates was performed because of clinical symptoms suggestive of hypoglycemia or in the presence of conventional risk factors (small-for-gestational-age, prematurity, anoxo-ischemia, hypothermia, macrosomia, gestational diabetes)...
2018: PloS One
https://www.readbyqxmd.com/read/29718876/effects-of-slow-breathing-rate-on-heart-rate-variability-and-arterial-baroreflex-sensitivity-in-essential-hypertension
#12
Changjun Li, Qinghua Chang, Jia Zhang, Wenshu Chai
This study is to investigate the effects of slow breathing on heart rate variability (HRV) and arterial baroreflex sensitivity in essential hypertension.We studied 60 patients with essential hypertension and 60 healthy controls. All subjects underwent controlled breathing at 8 and 16 breaths per minute. Electrocardiogram, respiratory, and blood pressure signals were recorded simultaneously. We studied effects of slow breathing on heart rate, blood pressure and respiratory peak, high-frequency (HF) power, low-frequency (LF) power, and LF/HF ratio of HRV with traditional and corrected spectral analysis...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29713051/difficult-to-control-hypertension-identification-of-clinical-predictors-and-use-of-ict-based-integrated-care-to-facilitate-blood-pressure-control
#13
Valeria Visco, Rosa Finelli, Antonietta Valeria Pascale, Pietro Mazzeo, Nicola Ragosa, Valentina Trimarco, Maddalena Illario, Michele Ciccarelli, Guido Iaccarino
Difficult-to-control (DTC) hypertension represents a burden in real life that can be partially solved through identification of the characteristics of clinical patterns and tailoring antihypertensive strategies, including ICT-enabled integrated care (ICT-IC). In the quest for clinical predictors of DTC hypertension, we screened 482 hypertensive patients who were consecutively referred to the departmental hypertension clinic. Following a data quality check, patients were divided into controlled (C, 49.37%) and uncontrolled (UC, 50...
May 1, 2018: Journal of Human Hypertension
https://www.readbyqxmd.com/read/29710536/depressor-effect-of-the-young-leaves-of-polygonum-hydropiper-linn-in-high-salt-induced-hypertensive-mice
#14
Sankar Devarajan, Eiji Yahiro, Yoshinari Uehara, Rieko Kuroda, Yoshio Hirano, Kaori Nagata, Shinichiro Miura, Keijiro Saku, Hidenori Urata
A novel chymase inhibitor has been reported to have depressor effect in salt-induced hypertension. Therefore, we examined the hypothesis that chymase inhibitory dried young leaves of Polygonum hydropiper (PPH) or young leaves extract of Polygonum hydropiper (PHE) could reduce salt-induced hypertension. In this study, 8-wk old wild-type mice were allocated into three experiments and experiment I included groups, I- normal water drinking, II- high salt (2% NaCl) water (HSW) drinking, and III- HSW plus PPH (500 mg kg-1 , orally) for 12-wk...
April 5, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29707413/end-stage-renal-failure-is-an-independent-risk-factor-for-1-year-mortality-after-hip-fracture-surgery
#15
Louise Woon Theng Lo, Xu Yanling, Andrew Chia Chen Chou, Tet Sen Howe, John Carson Allen, Joyce Suang Bee Koh
Introduction: End-stage renal failure (ESRF) with its associated comorbidities increase postoperative mortality in hip fracture patients. This study investigated the association of ESRF with various comorbidities in patients on dialysis and assessed rates ESRF as an independent risk factor for all-cause postoperative 1- year mortality rates. Methods: This was a retrospective cohort study on patients aged 55 years and older who underwent their first nonpathological, low-energy hip fracture surgery at an Asian tertiary hospital from June 2007 to 2012...
2018: Geriatric Orthopaedic Surgery & Rehabilitation
https://www.readbyqxmd.com/read/29701421/rapid-pacing-for-thoracic-endovascular-aortic-repair-a-case-report
#16
Hugo Silva, Andreia Fernandes, João Rodrigues, Daniel Brandão, Manuela Vieira, Catarina Celestino
INTRODUCTION: Endovascular aortic interventions are suitable alternatives to open surgery, being less invasive and having lower mortality and complications. Accurate positioning of the stent graft is a critical point because of systolic thrush. Techniques used to prevent it include pharmacological (antihypertensive drugs, nitroglycerin, adenosine) and mechanical methods (temporary caval occlusion by balloon). Rapid Right Ventricular Pacing (RRVP) is an emerging alternative with good patient tolerance and low level of complications...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29694647/atrial-fibrillation-and-hypertension-state-of-the-art
#17
Soufia Naccache, Mouna Ben Kilani, Rami Tlili, Youssef Ben Ameur, Mohamed Rachid Boujnah
Atrial fibrillation and hypertension are often coexistent. Their incidence increases with advancing age and they are responsible for considerable morbidity and mortality. The relation between theses 2 diseases has long been discussed and determined by clinical studies. Left ventricular hypertrophy and left atrial remodeling during hypertension favor the development of atrial fibrillation. AF during hypertension increases the risk of thromboembolic complications and heart failure. In patients with hypertension, pharmacological treatment may control the cardiac structural changes and retard or prevent the occurrence of atrial fibrillation...
July 2017: La Tunisie Médicale
https://www.readbyqxmd.com/read/29694556/exercise-training-attenuates-sympathetic-activity-and-improves-morphometry-of-splenic-arterioles-in-spontaneously-hipertensive-rats
#18
Marina de Paiva Lemos, Gustavo Ribeiro da Mota, Moacir Marocolo, Carla Cristina de Sordi, Rosângela Soares Chriguer, Octávio Barbosa Neto
BACKGROUND: Alterations in the structure of resistance vessels contribute to elevated systemic vascular resistance in hypertension and are linked to sympathetic hyperactivity and related lesions in target organs. OBJECTIVE: To assess the effects of exercise training on hemodynamic and autonomic parameters, as well as splenic arteriolar damages in male Wistar Kyoto (WKY) and Spontaneously Hypertensive Rats (SHR). METHODS: Normotensive sedentary (WKYS) and trained (WKYT) rats, and hypertensive sedentary (SHRS) and trained (SHRT) rats were included in this study...
March 2018: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/29694277/inhibition-of-bdnf-signaling-in-the-paraventricular-nucleus-of-the-hypothalamus-lowers-acute-stress-induced-pressor-responses
#19
Chris L Schaich, Theresa L Wellman, Zachary Einwag, Richard A Dutko, Benedek Erdos
Brain-derived neurotrophic factor (BDNF) expression increases in the paraventricular nucleus of the hypothalamus (PVN) during stress, and our recent studies indicate that BDNF induces sympathoexcitatory and hypertensive responses when injected acutely or overexpressed chronically in the PVN. However, it remained to be investigated whether BDNF is involved in the mediation of stress-induced cardiovascular responses. Here, we tested the hypothesis that inhibition of the high-affinity BDNF receptor TrkB in the PVN diminishes acute stress-induced cardiovascular responses...
April 25, 2018: Journal of Neurophysiology
https://www.readbyqxmd.com/read/29690736/-observation-on-safety-and-effects-of-analgesic-and-sedative-treatment-in-severely-burned-patients-during-shock-stage
#20
R B Li, Q Chen, H Y Zhang, H A Deng, G H Guo, Y G Mao, Z H Fu
Objective: To observe the safety and effects of application of analgesic and sedative drugs in severely burned patients during shock stage. Methods: One hundred and eighty patients with severe burns, conforming to the study criteria, were admitted to our unit from August 2014 to August 2016. Patients were divided into analgesia and sedation group and control group according to whether receiving analgesic and sedative treatment or not, with 90 cases in each group. Patients in control group received conventional treatment, while those in analgesia and sedation group received analgesic and sedative treatment for 24 hours besides conventional treatment...
April 20, 2018: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
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