Mariana Tannoury, Marianne Ayoub, Léa Dehgane, Ivan Nemazanyy, Kenza Dubois, Charlotte Izabelle, Aurélie Brousse, Damien Roos-Weil, Karim Maloum, Hélène Merle-Béral, Brigitte Bauvois, Bruno Saubamea, Elise Chapiro, Florence Nguyen-Khac, Delphine Garnier, Santos A Susin
Chronic lymphocytic leukemia (CLL) is still an incurable disease, with many patients developing resistance to conventional and targeted therapies. To better understand the physiology of CLL and facilitate the development of innovative treatment options, we examined specific metabolic features in the tumor CLL B-lymphocytes. We observed metabolic reprogramming, characterized by a high level of mitochondrial oxidative phosphorylation activity, a low glycolytic rate, and the presence of C2- to C6-carnitine end-products revealing an unexpected, essential role for peroxisomal fatty acid beta-oxidation (pFAO)...
December 6, 2023: Leukemia