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Immature platelet

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https://www.readbyqxmd.com/read/28714327/elevated-levels-of-circulating-cell-free-dna-and-neutrophil-proteins-are-associated-with-neonatal-sepsis-and-necrotizing-enterocolitis-in-immature-mice-pigs-and-infants
#1
Duc Ninh Nguyen, Allan Stensballe, Jacqueline Cy Lai, Pingping Jiang, Anders Brunse, Yanqi Li, Jing Sun, Carina Mallard, Tom Skeath, Nicholas D Embleton, Janet E Berrington, Per T Sangild
Preterm infants are highly susceptible to late-onset sepsis (LOS) and necrotizing enterocolitis (NEC), but disease pathogenesis and specific diagnostic markers are lacking. Circulating cell-free DNA (cfDNA) and immune cell-derived proteins are involved in multiple immune diseases in adults but have not been investigated in preterm neonates. We explored the relation of circulating neutrophil-associated proteins and cfDNA to LOS and/or NEC. Using a clinically relevant preterm pig model of spontaneous LOS and NEC development, we investigated neutrophil-associated proteins and cfDNA in plasma, together with cytokines in gut tissues...
January 1, 2017: Innate Immunity
https://www.readbyqxmd.com/read/28712634/management-of-dens-invaginatus-type-ii-associated-with-immature-apex-and-large-periradicular-lesion-using-platelet-rich-fibrin-and-biodentine
#2
Shruti Goel, Ruchika Roongta Nawal, Sangeeta Talwar
Dens invaginatus (DI) poses peculiar challenges in endodontic treatment of teeth because of distortion of pulpal space. A case of Oehlers type II DI with open apex and large periapical lesion is reported. The case was managed using cone-beam computed tomography (CBCT), operating microscope, platelet-rich fibrin (PRF), and Biodentine. A 15-year-old male patient presented with palatal swelling. Pulp sensibility testing of right maxillary lateral incisor was negative. Intraoral periapical digital radiograph revealed an Oehlers type II DI with open apex and periapical radiolucency...
July 13, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28701961/insights-into-the-development-of-the-adult-leydig-cell-lineage-from-stem-leydig-cells
#3
REVIEW
Leping Ye, Xiaoheng Li, Linxi Li, Haolin Chen, Ren-Shan Ge
Adult Leydig cells (ALCs) are the steroidogenic cells in the testes that produce testosterone. ALCs develop postnatally from a pool of stem cells, referred to as stem Leydig cells (SLCs). SLCs are spindle-shaped cells that lack steroidogenic cell markers, including luteinizing hormone (LH) receptor and 3β-hydroxysteroid dehydrogenase. The commitment of SLCs into the progenitor Leydig cells (PLCs), the first stage in the lineage, requires growth factors, including Dessert Hedgehog (DHH) and platelet-derived growth factor-AA...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28672770/performance-of-automated-digital-cell-imaging-analyzer-sysmex-di-60
#4
Hyeong Nyeon Kim, Mina Hur, Hanah Kim, Seung Wan Kim, Hee-Won Moon, Yeo-Min Yun
BACKGROUND: The Sysmex DI-60 system (DI-60, Sysmex, Kobe, Japan) is a new automated digital cell imaging analyzer. We explored the performance of DI-60 in comparison with Sysmex XN analyzer (XN, Sysmex) and manual count. METHODS: In a total of 276 samples (176 abnormal and 100 normal samples), white blood cell (WBC) differentials, red blood cell (RBC) classification and platelet (PLT) estimation by DI-60 were compared with the results by XN and/or manual count. RBC morphology between pre-classification and verification was compared according to the ICSH grading criteria...
June 16, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28662879/use-of-platelet-rich-plasma-in-endodontic-procedures-in-adults-regeneration-or-repair-a-report-of-3-cases-with-5%C3%A2-years-of-follow-up
#5
José Francisco Gaviño Orduña, Javier Caviedes-Bucheli, María C Manzanares Céspedes, Esther Berástegui Jimeno, Benjamín Martín Biedma, Juan José Segura-Egea, José López-López
INTRODUCTION: Regenerative endodontic procedures (REP) are a promising alternative for necrotic immature teeth in adolescents and children, but very little evidence is available on this alternative in long-lasting necrotic teeth with open apices in adults. REPs are designed to replace damaged structures of the pulp-dentin complex, but no regeneration has been obtained in any of the cases described in necrotic immature permanent teeth with apical periodontitis with histologic results. The results are limited to periapical tissue repair with increasing root length, thickening of the root walls, and apical closure in young patients...
June 26, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28649771/evaluation-of-the-sysmex-xn-550-a-novel-compact-haematology-analyser-from-the-xn-l-%C3%A2-series-compared-to-the-xn-20-system
#6
H Tailor, I Mackie, A Mellick, S Machin
INTRODUCTION: The XN-550 is a new, automated, compact, haematology analyser designed to generate a full blood count with a standard five-part white blood cell differential and an immature granulocyte count, as well as an optional reticulocyte and optical platelet (PLT) counts. The aim of the study was to evaluate the performance of the XN-550 and compare it to the established XN-20 system. METHODS: We evaluated the basic parameter and special measurement channels of the XN-550, using the XN-20 (which has a similar operating system), as a reference analyser...
June 25, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28623328/platelet-rich-plasma-induces-post-natal-maturation-of-immature-articular-cartilage-and-correlates-with-loxl1-activation
#7
Yadan Zhang, Ben J Morgan, Rachel Smith, Christopher R Fellows, Catherine Thornton, Martyn Snow, Lewis W Francis, Ilyas M Khan
Platelet-rich plasma (PRP) is used to stimulate the repair of acute and chronic cartilage damage even though there is no definitive evidence of how this is achieved. Chondrocytes in injured and diseased situations frequently re-express phenotypic biomarkers of immature cartilage so tissue maturation is a potential pathway for restoration of normal structure and function. We used an in vitro model of growth factor-induced maturation to perform a comparative study in order to determine whether PRP can also induce this specific form of remodeling that is characterised by increased cellular proliferation and tissue stiffness...
June 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28611471/evaluation-of-the-immature-platelet-fraction-contribute-to-the-differential-diagnosis-of-hereditary-immune-and-other-acquired-thrombocytopenias
#8
F L B Ferreira, M P Colella, S S Medina, C Costa-Lima, M M L Fiusa, L N G Costa, F A Orsi, J M Annichino-Bizzacchi, K Y Fertrin, M F P Gilberti, M C Ozelo, E V De Paula
The differential diagnosis of immune (ITP) and hereditary macrothrombocytopenia (HM) is key to patient management. The immature platelet fraction (IPF) represents the subset of circulating platelets with higher RNA content, and has been shown to distinguish hypo- from hyperproliferative thrombocytopenias. Here we evaluated the diagnostic accuracy of IPF in the differential diagnosis between HM and other thrombocytopenias in a population of patients with post-chemotherapy thrombocytopenia (n = 56), bone marrow failure (n = 22), ITP (n = 105) and HM (n = 27)...
June 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28562514/actn1-related-macrothrombocytopenia-a-novel-entity-in-the-progressing-field-of-pediatric-thrombocytopenia
#9
Helene Boutroux, Bianca David, Paul Guéguen, Pierre Frange, Anne Vincenot, Guy Leverger, Rémi Favier
The most common cause of thrombocytopenia in children is immune thrombocytopenia. Nevertheless, some atypical cases should evoke the hypothesis of genetic thrombocytopenia. Indeed, in the past years, 30 new genes had been described in the field of inherited thrombocytopenia. We report a series of 11 cases of a newly diagnosed entity: ACTN1-related macrothrombocytopenia. Mutations in the gene ACTN1 cause mild macrothrombocytopenia characterized by elevated mean platelet volume and elevated immature platelet fraction, and low bleeding tendency...
May 29, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/28548028/developmental-differences-between-newborn-and-adult-mice-in-response-to-romiplostim
#10
Katherine A Sparger, Haley Ramsey, Viola Lorenz, Zhi-Jian Liu, Henry A Feldman, Nan Li, Tahirih Laforest, Martha C Sola-Visner
Thrombocytopenia is frequent among sick neonates. While most cases are transient, some neonates experience prolonged and severe thrombocytopenia. These infants often pose diagnostic and therapeutic challenges, and may receive large numbers of platelet transfusions. Romiplostim (ROM) is a thrombopoietin (TPO)-receptor-agonist approved for treatment of adults with chronic immune thrombocytopenia (ITP). The immature platelet fraction (IPF) is a novel measure of newly produced platelets, which could aid with the diagnostic evaluation of thrombocytopenic neonates...
May 26, 2017: Platelets
https://www.readbyqxmd.com/read/28529149/autotransplantation-of-third-molars-with-platelet-rich-plasma-for-immediate-replacement-of-extracted-non-restorable-teeth-a-case-series
#11
Jorge Gonzalez-Ocasio, Mark Stevens
PURPOSE: The aim of this study was to examine the use of platelet-rich plasma (PRP) for autotransplantation of third molars as a successful technique to provide immediate tooth structure for space maintenance and masticatory function when premature loss of a permanent tooth occurs and other dental restorative options are not indicated. MATERIALS AND METHODS: This study included 10 healthy patients 10 to 17 years of age with at least 1 immature third molar (one to two thirds of root formation) used to replace extracted non-restorable teeth...
April 25, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28482628/red-blood-cell-and-platelet-parameters-are%C3%A2-sepsis-predictors-in-an-escherichia-coli%C3%A2-induced-lethal-porcine-model
#12
Judit Tóth, Ildikó Beke Debreceni, Mariann Berhés, Endre Hajdú, Ádám Deák, Katalin Pető, Judit Szabó, Norbert Németh, Béla Fülesdi, János Kappelmayer
OBJECTIVE: In a fulminant porcine sepsis model, we determined the kinetics of hypoxia induced changes in relation to sepsis parameters and markers of organ damage. METHODS: Female pigs were challenged by live Escherichia coli and samples were analysed up to 4 hours. Bone marrow reactions were determined by analysing immature forms of peripheral blood cells by a hematology analyser and light microscopy. Platelet mitochondrial membrane depolarisation was determined by flow cytometry...
May 5, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/28479317/biological-variation-of-platelet-parameters-determined-by-the-sysmex-xn-hematology-analyzer
#13
Sabrina Buoro, Michela Seghezzi, Barbara Manenti, Aurelio Pacioni, Anna Carobene, Ferruccio Ceriotti, Cosimo Ottomano, Giuseppe Lippi
BACKGROUND: This study was aimed to define the short- and medium-term biological variation (BV) estimates, the index of individuality and the reference change value (RCV) of platelet count, platelet distribution width, mean platelet volume, platelet larger cell ratio, plateletcrit and immature platelet fraction. METHODS: The study population consisted of 43 health subjects, who participated to the assessment of medium-term (21 subjects; blood sampling once a week for 5 consecutive weeks) and short-term (22 subjects; blood sampling once a day for 5 consecutive days) BV study, using Sysmex XN-module...
July 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28455282/identifying-and-enriching-platelet-producing-human-stem-cell-derived-megakaryocytes-using-factor-v-uptake
#14
Xiuli Sim, Danuta Jarocha, Vincent Hayes, Hayley A Hanby, Michael S Marks, Rodney M Camire, Deborah L French, Mortimer Poncz, Paul Gadue
Stem cell-derived platelets have the potential to replace donor platelets for transfusion. Defining the platelet-producing megakaryocytes (MKs) within the heterogeneous MK culture may help to optimize the in vitro generation of platelets. Using 2 human stem cell models of megakaryopoiesis, we identified novel MK populations corresponding to distinct maturation stages. An immature, low granular (LG) MK pool (defined by side scatter on flow cytometry) gives rise to a mature high granular (HG) pool, which then becomes damaged by apoptosis and glycoprotein Ib α chain (CD42b) shedding...
July 13, 2017: Blood
https://www.readbyqxmd.com/read/28447765/plasma-microrna-451-as-a-novel-hemolytic-marker-for-%C3%AE-0-thalassemia-hbe-disease
#15
Kamonlak Leecharoenkiat, Yuka Tanaka, Yasuko Harada, Porntip Chaichompoo, Orawan Sarakul, Yasunobu Abe, Duncan Richard Smith, Suthat Fucharoen, Saovaros Svasti, Tsukuru Umemura
In Southeast Asia, particularly in Thailand, β0-thalassemia/hemoglobin E (HbE) disease is a common hereditary hematological disease. It is associated with pathophysiological processes, such as the intramedullary destruction of immature erythroid cells and peripheral hemolysis of mature red blood cells. MicroRNA (miR) sequences, which are short non-coding RNA that regulate gene expression in a suppressive manner, serve a crucial role in human erythropoiesis. In the present study, the plasma levels of the erythroid-expressed miRNAs, miR‑451 and miR‑155, were analyzed in 23 patients with β0-thalassemia/HbE and 16 control subjects...
May 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28415948/use-of-platelet-rich-plasma-for-regeneration-in-non-vital-immature-permanent-teeth-clinical-and-cone-beam-computed-tomography-evaluation
#16
Adel Alagl, Sumit Bedi, Khalid Hassan, Jehan AlHumaid
Objective This study was performed to assess the clinical and radiological outcomes of a revascularization procedure in immature teeth with apical periodontitis using platelet-rich plasma (PRP). The PRP protocol and conventional revascularization protocol, which used a blood clot as the scaffold, were compared. Methods Thirty non-vital immature permanent teeth were randomly categorized into two groups. After disinfecting the root canal space with triple antibiotic paste (1:1:1 ciprofloxacin, metronidazole, and cefaclor), a tissue scaffold was created using either PRP or a blood clot (control) and covered with white mineral trioxide aggregate...
April 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28394090/analysis-of-platelet-derived-extracellular-vesicles-in-plateletpheresis-concentrates-a-multicenter-study
#17
Anne Black, Evelyn Orsó, Reinhard Kelsch, Melanie Pereira, Julian Kamhieh-Milz, Abdulgabar Salama, Michael B Fischer, Eduardo Meyer, Beat M Frey, Gerd Schmitz
BACKGROUND: Routine quantification of platelet-derived extracellular vesicles (PL-EVs) may be useful in the quality control (QC) of platelet concentrates (PCs). The aim of this multicenter study was to establish and validate a consensus protocol for the standardized PL-EV quantification using conventional flow cytometers. STUDY DESIGN AMD METHODS: Eighty-six PCs were investigated in five blood transfusion centers (A-E) on Days 0 and 5. The centers used different apheresis instruments: Trima Accel (n = 56) and/or Amicus (n = 30)...
April 10, 2017: Transfusion
https://www.readbyqxmd.com/read/28388444/immature-platelet-fraction-and-the-extent-of-coronary-artery-disease-a-single-centre-study
#18
Monica Verdoia, Matteo Nardin, Roberta Rolla, Paolo Marino, Giorgio Bellomo, Harry Suryapranata, Giuseppe De Luca
BACKGROUND AND AIMS: Immature platelet fraction (IPF) represents the quote of younger and larger sized circulating platelets, a potential marker of platelet reactivity and major cardiovascular events. We aimed to assess the relationship between IPF levels and the prevalence and extent of coronary artery disease (CAD) in patients undergoing coronary angiography. METHODS: A cohort of consecutive patients undergoing coronary angiography in a single centre were included...
May 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28383532/the-immature-platelet-fraction-creating-neonatal-reference-intervals-and-using-these-to-categorize-neonatal-thrombocytopenias
#19
B C MacQueen, R D Christensen, E Henry, A M Romrell, T J Pysher, S T Bennett, M C Sola-Visner
OBJECTIVE: The immature platelet fraction (IPF) is a laboratory measurement analogous to the reticulocyte count, but reflecting the thrombopoietic state. Similar to a reticulocyte count, it can be expressed as a percent (IPF%=percent of platelets that are immature) or as an absolute number per μl blood; the immature platelet count (IPC=IPF% × platelets per μl of blood). STUDY DESIGN: Using a retrospective analysis of de-identified data from non-thrombocytopenic neonates, we created reference intervals for IPF% and IPC...
April 6, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/28379623/on-pump-cardiac-surgery-enhances-platelet-renewal-and-impairs-aspirin-pharmacodynamics-effects-of-improved-dosing-regimens
#20
V Cavalca, B Rocca, F Veglia, G Petrucci, B Porro, V Myasoedova, R De Cristofaro, L Turnu, A Bonomi, P Songia, L Cavallotti, M Zanobini, M Camera, F Alamanni, A Parolari, C Patrono, E Tremoli
On-pump cardiac surgery may trigger inflammation and accelerate platelet cyclooxygenase-1 renewal, thereby modifying low-dose aspirin pharmacodynamics. Thirty-seven patients on standard aspirin 100mg once-daily were studied before surgery and randomized within 36 hours post-surgery to 100mg once-daily, 100mg twice-daily or 200mg once-daily for 90 days. On day 7 post-surgery, immature and mature platelets, platelet mass, thrombopoieitin, glycocalicin, leukocytes, C-reactive protein, and interleukin-6 significantly increased...
April 5, 2017: Clinical Pharmacology and Therapeutics
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