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Serum Androgens level

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https://www.readbyqxmd.com/read/29666834/androgen-action-in-prostate-function-and-disease
#1
REVIEW
Partha P Banerjee, Subhadra Banerjee, Terry R Brown, Barry R Zirkin
Benign prostatic hyperplasia (BPH) is an enlargement of the prostate gland that is frequently found in aging men. Androgens are essential for the development and differentiated function of the prostate, as well as for proliferation and survival of prostatic cells. In man, dog and rodent, there are age-related decreases in serum testosterone. Despite the lower serum testosterone levels, benign prostatic hyperplasia increases with age in men and dogs, while age-dependent prostatic hyperplasia develops in the dorsal and lateral lobes of the rat prostate...
2018: American Journal of Clinical and Experimental Urology
https://www.readbyqxmd.com/read/29666348/testosterone-levels-and-the-genetic-variation-of-sex-hormone-binding-globulin-gene-of-bubalus-bubalis-bulls-in-egypt
#2
Samy Naeem, Ahmed Ghoneim, Gamal Abd-Allah, Omaima Hassan
Testosterone is themain plasma androgen produced and secreted by male testis. To be bioactive, it binds to sex hormonebinding globulin (SHBG), i.e. the major transporter protein of sex steroids in the blood of mammals and other vertebrate species.Firstly, this study aimed to determine the levels of testosterone in different-age groups of buffalo bulls (Bubalus bubalis) in Egypt, and secondly to screen the genetic polymorphisms in their SHBG gene and to investigatewhether these polymorphisms are associated with the level of the circulating serum testosterone...
March 2018: Journal of Genetics
https://www.readbyqxmd.com/read/29663637/reproductive-health-obesity-and-cardiometabolic-risk-factors-among-samoan-women
#3
H Maredia, N L Hawley, G Lambert-Messerlian, U Fidow, M S Reupena, T Naseri, S T McGarvey
OBJECTIVES: Obesity leads to deleterious effects on not only cardiovascular health but also on the reproductive health of women. We estimate the prevalence of menstrual irregularity and of polycystic ovarian syndrome (PCOS) in Samoan women, among whom obesity prevalence is extremely high. We explore the association of these reproductive health conditions with adiposity, cardiometabolic risk factors, and androgen levels. METHODS: A cross-sectional sample of Samoan women 25-39 years of age (n = 470) from a larger population-based genome-wide association study of adiposity and cardiometabolic disease was assessed for the prevalence of oligomenorrhea/amenorrhea (OM/AM) using a self-reported questionnaire...
April 16, 2018: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/29652114/associations-between-vitamin-d-levels-and-polycystic-ovary-syndrome-pcos-phenotypes
#4
Erin M Davis, Jennifer D Peck, Karl R Hansen, Barbara R Neas, LaTasha B Craig
BACKGROUND: Studies comparing serum 25-hydroxyvitamin D concentrations in women with and without PCOS have produced inconsistent results. Additionally, no previous studies have evaluated associations between vitamin D and specific PCOS phenotypes. METHODS: This case-control study was conducted among women undergoing intrauterine insemination. Cases (n=137) were diagnosed with PCOS and then further classified into 3 diagnostic phenotypes based on combinations of the Rotterdam criteria [ovulatory dysfunction +polycystic ovaries (n=55); ovulatory dysfunction +androgen excess (n=15); and ovulatory dysfunction, +polycystic ovaries, +androgen excess (n=67)]...
April 12, 2018: Minerva Endocrinologica
https://www.readbyqxmd.com/read/29643806/diverged-effects-of-piperine-on-testicular-development-stimulating-leydig-cell-development-but-inhibiting-spermatogenesis-in-rats
#5
Xianwu Chen, Fei Ge, Jianpeng Liu, Suhao Bao, Yong Chen, Dongli Li, Yong Li, Tongliang Huang, Xiaofang Chen, Qiqi Zhu, Qingquan Lian, Ren-Shan Ge
Background: Piperine is the primary pungent alkaloid isolated from the fruit of black peppercorns. Piperine is used frequently in dietary supplements and traditional medicines. The objective of the present study was to investigate the effects of piperine on the testis development in the pubertal rat. Methods: Piperine (0 or 5 or 10 mg/kg) was gavaged to 35-day-old male Sprague-Dawley rats for 30 days. Serum levels of testosterone (T), luteinizing hormone (LH), and follicle-stimulating hormone (FSH) were measured...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29624102/exogenous-testosterone-does-not-induce-or-exacerbate-the-metabolic-features-associated-with-pcos-among-transgender-men
#6
Kelly J Chan, Jennifer J Liang, Divya Jolly, Jamie D Weinand, Joshua D Safer
OBJECTIVES: Polycystic ovarian syndrome (PCOS) is a complex condition which can include menstrual irregularity, metabolic derangement, and increased androgen levels. The mechanism of PCOS is unknown. Some suggest that excess production of androgens by the ovaries may cause or exacerbate the metabolic findings. The purpose of this study was to assess the role of increased testosterone on metabolic parameters on individuals presumed to be chromosomally female by examination of these parameters in hormone-treated transgender men...
April 6, 2018: Endocrine Practice
https://www.readbyqxmd.com/read/29623697/efficacy-and-safety-of-a-mixed-extract-of-trigonella-foenum-graecum-seed-and-lespedeza-cuneata-in-the-treatment-of-testosterone-deficiency-syndrome-a-randomized-double-blind-placebo-controlled-clinical-trial
#7
Hyun Jun Park, Kyeong Soo Lee, Eun Kyoung Lee, Nam Cheol Park
PURPOSE: The aim of this study was to investigate the efficacy and safety of a mixed extract of Trigonella foenum-graecum seed and Lespedeza cuneata (TFGL) for the treatment of testosterone deficiency syndrome (TDS). MATERIALS AND METHODS: Patients were instructed to take a placebo or 200 mg TFGL capsule twice per day for 8 weeks. The primary efficacy variable was the change from baseline in the Aging Males' Symptoms scale (AMS), as well as levels of serum total and free testosterone...
March 22, 2018: World Journal of Men's Health
https://www.readbyqxmd.com/read/29618085/reassessing-free-testosterone-calculation-by-liquid-chromatography-tandem-mass-spectrometry-direct-equilibrium-dialysis
#8
Tom Fiers, Frederick Wu, Paolo Moghetti, Dirk Vanderschueren, Bruno Lapauw, Jean Marc Kaufman
BACKGROUND: Assessment of free testosterone (FT) might help evaluate androgen status in subjects with borderline total testosterone (T) and/or altered SHBG levels. However, validity of different methods to measure or calculate FT is matter for debate. METHODS: Serum from 183 women and 146 men was analysed using equilibrium dialysis (ED) with FT directly measured by LC/MS-MS. FT calculation was re-evaluated for the mass action law-based equation according to Vermeulen (cFT-V) , empirical equations according to Ly (cFT-L) and a recently proposed calculation based on a multi-step, dynamic, allosteric model according to Zakharov (cFT-Z)...
March 29, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29614340/maternal-lipopolysaccharide-exposure-results-in-glucose-metabolism-disorders-and-sex-hormone-imbalance-in-male-offspring
#9
Mei Zhao, Li Yuan, Man-Man Yuan, Li-Li Huang, Chang Su, Yuan-Hua Chen, Yu-Ying Yang, Yan Hu, De-Xiang Xu
An adverse intrauterine environment may be an important factor contributing to the development of type 2 diabetes in later life. The present study investigated the longitudinal effects of maternal lipopolysaccharide (LPS) exposure during the third trimester on glucose metabolism and sex hormone balance in the offspring. Pregnant mice were intraperitoneally injected with LPS (50 μg/kg) daily from gestational day (GD) 15 to GD17. Glucose tolerance test (GTT) and insulin tolerance test (ITT) were assessed at postnatal day (PND) 60 and PND120...
March 31, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29605576/effects-of-maternal-dietary-selenium-se-enriched-yeast-on-testis-development-testosterone-level-and-testicular-steroidogenesis-related-gene-expression-of-their-male-kids-in-taihang-black-goats
#10
Lei Shi, Ruigao Song, Xiaolei Yao, Yunli Duan, Youshe Ren, Chunxiang Zhang, Wenbin Yue, Fulin Lei
To investigate the effects of maternal dietary selenium (Se-enriched yeast) on testis development, testosterone level and steroidogenesis-related gene expression in testis of their male kids, selected pregnant Taihang Black Goats were randomly allotted to four treatment groups. They were fed the basal gestation and lactation diets supplemented with 0 (control), 0.5, 2.0 and 4.0 mg of Se/kg DM. Thirty days after weaning, testes were collected from the kids. After the morphological development status of testis was examined, tissue samples were collected for analyzing testosterone concentration and histological parameters...
March 26, 2018: Theriogenology
https://www.readbyqxmd.com/read/29602821/a-prospective-comparison-of-18-f-sodium-fluoride-pet-ct-and-psma-targeted-18-f-dcfbc-pet-ct-in-metastatic-prostate-cancer
#11
Stephanie A Harmon, Ethan Bergvall, Esther Mena, Joanna H Shih, Stephen Adler, Yolanda McKinney, Sherif Mehralivand, Deborah E Citrin, Anna Couvillon, Ravi Madan, James Gulley, Ronnie C Mease, Paula M Jacobs, Martin G Pomper, Baris Turkbey, Peter L Choyke, M Liza Lindenberg
Purpose: The purpose of this study was to compare the diagnostic performance of18 F-DCFBC positron emission tomography/computed tomography (PET/CT), a first generation18 F-labelled prostate-specific membrane antigen (PSMA)-targeted agent, and18 F-NaF PET/CT, a sensitive marker of osteoblastic activity, in a prospective cohort of patients with metastatic prostate cancer. Methods: Twenty-eight prostate cancer patients with metastatic disease on conventional imaging prospectively received up to four PET/CT scans...
March 30, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29596864/effect-of-low-androgen-status-on-the-expression-of-p2y-receptors-in-the-corpus-cavernosum-of-rats
#12
Pan Liu, Jun Jiang, Jiyi Xia, Rui Jiang
OBJECTIVE: To determine whether low androgen status impacts erectile function by regulating the expression of the G protein-coupled P2Y receptors (P2Y1, P2Y2, P2Y4, and P2Y6) in the corpus cavernosum penis of rats. METHODS: A total of 36 healthy, 8-week-old, male Sprague-Dawley (SD) rats were randomly allocated into 6 groups: 4 weeks of androgen replacement therapy post castration (group A); 4 weeks post castration (group B); 4 weeks post sham operation (group C); 8 weeks of androgen replacement therapy post castration (group D); 8 weeks post castration (group E); and 8 weeks post sham operation (group F)...
March 26, 2018: Urology
https://www.readbyqxmd.com/read/29584789/the-effect-of-cag-repeats-length-on-differences-in-hirsutism-among-healthy-israeli-women-of-different-ethnicities
#13
Naomi Weintrob, Ori Eyal, Meital Slakman, Anat Segev Becker, Galit Israeli, Ofra Kalter-Leibovici, Shay Ben-Shachar
PURPOSE: Variations in the degree of hirsutism among women of different ethnic backgrounds may stem from multiple etiologies. Shorter length of the polymorphic CAG repeats of the androgen receptor (AR) gene may be associated with increased activity of the receptor leading to hirsutism. We hypothesized that there are ethnic differences in the degree of hirsutism that is unrelated to androgen levels among Israeli women, and that the CAG repeats length may contribute to these differences...
2018: PloS One
https://www.readbyqxmd.com/read/29580815/age-dependent-variations-in-the-deep-brain-photoreceptors-dbps-gnrh-gnih-system-and-testicular-steroidogenesis-in-japanese-quail-coturnix-coturnix-japonica
#14
Somanshu Banerjee, Saba Shahin, Chandra Mohini Chaturvedi
The complex physiology of aging involves a number of molecular and biochemical events, manifested as signs of senescence. Japanese quail is a very unique and advantageous model to study the signs and symptoms of senescence in the central and peripheral modules of HPG axis. In the present study, we have investigated the age dependent variations in hypothalamic deep brain photoreceptors (DBPs), central GnRH-I/II-GnIH-Mel1c R system, testicular GnRH-GnIH system, testicular steroidogenic genes and proteins, androgen receptor (AR) and serum testosterone level in quail of different age groups [3-wk (sexually immature), 6-wk (sexually mature and crossed the puberty), 16-wk (adult, sexually active and showing full breeding phase) and 144-wk (aged)]...
March 23, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29571795/texture-analysis-of-apparent-diffusion-coefficient-maps-for-treatment-response-assessment-in-prostate-cancer-bone-metastases-a-pilot-study
#15
Carolin Reischauer, René Patzwahl, Dow-Mu Koh, Johannes M Froehlich, Andreas Gutzeit
OBJECTIVE: To evaluate whole-lesion volumetric texture analysis of apparent diffusion coefficient (ADC) maps for assessing treatment response in prostate cancer bone metastases. MATERIALS AND METHODS: Texture analysis is performed in 12 treatment-naïve patients with 34 metastases before treatment and at one, two, and three months after the initiation of androgen deprivation therapy. Four first-order and 19 second-order statistical texture features are computed on the ADC maps in each lesion at every time point...
April 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/29569152/predicting-mortality-and-incident-immobility-in-older-belgian-men-by-characteristics-related-to-sarcopenia-and-frailty
#16
C Kruse, S Goemaere, S De Buyser, B Lapauw, P Eiken, P Vestergaard
There is an increasing awareness of sarcopenia in older people. We applied machine learning principles to predict mortality and incident immobility in older Belgian men through sarcopenia and frailty characteristics. Mortality could be predicted with good accuracy. Serum 25-hydroxyvitamin D and bone mineral density scores were the most important predictors. INTRODUCTION: Machine learning principles were used to predict 5-year mortality and 3-year incident severe immobility in a population of older men by frailty and sarcopenia characteristics...
March 22, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29566165/leydig-cells-formation-function-and-regulation
#17
Barry R Zirkin, Vassilios Papadopoulos
Herein we summarize important discoveries made over many years about Leydig cell function and regulation. During the fetal period, fetal Leydig cells produce the high levels of androgen (testosterone or androstenedione, depending upon the species) required for differentiation of male genitalia and brain masculinization. Androgen production declines with loss of these cells, reaching a nadir at postpartum. Testosterone then gradually increases to high levels with adult Leydig cell development from stem cells...
March 16, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29564317/serum-visfatin-levels-in-non-obese-women-with-polycystic-ovary-syndrome-and-matched-controls
#18
Jin Ju Kim, Young Min Choi, Min A Hong, Min Jeong Kim, Soo Jin Chae, Sun Mie Kim, Kyu Ri Hwang, Sang Ho Yoon, Seung Yup Ku, Chang Suk Suh, Seok Hyun Kim
Objective: The purpose of the current study was to compare the circulating levels of visfatin between women with polycystic ovary syndrome (PCOS) and those without PCOS and to assess the correlations between visfatin levels and various parameters. Methods: This case-control study recruited 74 PCOS patients and 74 age- and body mass index (BMI)-matched controls. Serum visfatin levels were evaluated using the enzyme-linked immunosorbent assay. Women with PCOS were divided into 2 subgroups based on the presence of clinical or biochemical hyperandrogenism...
March 2018: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/29562689/gc-ms-based-endometabolome-analysis-differentiates-prostate-cancer-from-normal-prostate-cells
#19
Ana Rita Lima, Ana Margarida Araújo, Joana Pinto, Carmen Jerónimo, Rui Henrique, Maria de Lourdes Bastos, Márcia Carvalho, Paula Guedes de Pinho
Prostate cancer (PCa) is an important health problem worldwide. Diagnosis and management of PCa is very complex because the detection of serum prostate specific antigen (PSA) has several drawbacks. Metabolomics brings promise for cancer biomarker discovery and for better understanding PCa biochemistry. In this study, a gas chromatography-mass spectrometry (GC-MS) based metabolomic profiling of PCa cell lines was performed. The cell lines include 22RV1 and LNCaP from PCa with androgen receptor (AR) expression, DU145 and PC3 (which lack AR expression), and one normal prostate cell line (PNT2)...
March 19, 2018: Metabolites
https://www.readbyqxmd.com/read/29562364/testosterone-therapy-in-men-with-hypogonadism-an-endocrine-society-clinical-practice-guideline
#20
Shalender Bhasin, Juan P Brito, Glenn R Cunningham, Frances J Hayes, Howard N Hodis, Alvin M Matsumoto, Peter J Snyder, Ronald S Swerdloff, Frederick C Wu, Maria A Yialamas
Objective: To update the "Testosterone Therapy in Men With Androgen Deficiency Syndromes" guideline published in 2010. Participants: The participants include an Endocrine Society-appointed task force of 10 medical content experts and a clinical practice guideline methodologist. Evidence: This evidence-based guideline was developed using the Grading of Recommendations, Assessment, Development, and Evaluation approach to describe the strength of recommendations and the quality of evidence...
March 17, 2018: Journal of Clinical Endocrinology and Metabolism
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