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Serum Androgens level

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https://www.readbyqxmd.com/read/28717276/testosterone-versus-clomiphene-citrate-in-managing-symptoms-of-hypogonadism-in-men
#1
Pranav Dadhich, Ranjith Ramasamy, Jason Scovell, Nathan Wilken, Larry Lipshultz
INTRODUCTION: Both clomiphene citrate (CC) and testosterone supplementation therapy (TST) are effective treatments for men with hypogonadism. We sought to compare changes in symptoms and treatment efficacy in hypogonadal men before and after receiving CC and TST. PATIENTS AND METHODS: 52 men who received TST and 23 men who received CC for symptomatic hypogonadism were prospectively followed for change in hormone levels and symptoms after treatment. These men were also compared to eugonadal men who were not on CC or TST during the same period...
July 2017: Indian Journal of Urology: IJU: Journal of the Urological Society of India
https://www.readbyqxmd.com/read/28715798/bone-mineral-density-in-women-living-with-complete-androgen-insensitivity-syndrome-and-intact-testes-or-removed-gonads
#2
Silvano Bertelloni, Maria C Meriggiola, Elenora Dati, Antonio Balsamo, Giampiero I Baroncelli
Complete androgen insensitivity syndrome (CAIS) is due to complete androgen resistance in androgen-dependent tissues. Since androgens are involved in growth, development, and mass maintenance of the skeleton, bone health may be a relevant clinical issue for improving quality of life of women living with CAIS. Bone mineral density (BMD) in women with CAIS and intact gonads has been reported in a normal range, although exceptions are known showing a low BMD mainly at the lumbar level. In women with CAIS and removed gonads, BMD is usually reduced at both the lumbar spine and femoral neck...
July 18, 2017: Sexual Development: Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation
https://www.readbyqxmd.com/read/28712786/the-relationship-between-hot-flashes-and-testosterone-recovery-after-12-months-of-androgen-suppression-for-men-with-localised-prostate-cancer-in-the-ascende-rt-trial
#3
M Dosani, W J Morris, S Tyldesley, T Pickles
AIMS: This study describes the proportion of men who experienced hot flashes (flashes), and the testosterone level at onset, peak frequency and cessation of flashes after 12 months of androgen deprivation therapy (ADT) in men undergoing curative-intent external beam radiation therapy (± brachytherapy boost). We also aimed to characterise testosterone recovery in this population. MATERIALS AND METHODS: This was a pre-specified secondary analysis of the ASCENDE-RT clinical trial...
July 13, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/28712091/contribution-of-genetic-factors-to-lower-dheas-in-patients-with-rheumatoid-arthritis
#4
Lucia Vernerova, Martina Mravcova, Lucia Paulikova, Miroslav Vlcek, Andrea Marko, Milada Meskova, Adela Penesova, Jozef Rovensky, Juraj Wendl, Katarina Raslova, Branislav Vohnout, Ivana Jochmanova, Ivica Lazurova, Zdenko Killinger, Guenter Steiner, Josef Smolen, Richard Imrich
OBJECTIVE: Lower production of adrenal androgens has been confirmed in females with rheumatoid arthritis (RA); however, the mechanisms of this finding are not completely understood. The aim of our study was to assess the contribution of genetic factors associated with variability of dehydroepiandrosterone sulfate (DHEAS) levels to lower DHEAS in female RA patients. METHODS: 448 RA and 648 healthy controls were genotyped for single-nucleotide polymorphisms (SNPs) in genes ZKSCAN5 (rs11761528), SULT2A1 (rs2637125), HHEX (rs2497306), and ARPC1A (rs740160)...
July 15, 2017: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/28711501/comparing-the-androgenic-and-estrogenic-properties-of-progestins-used-in-contraception-and-hormone-therapy
#5
Renate Louw-du Toit, Meghan S Perkins, Janet P Hapgood, Donita Africander
Progestins used in endocrine therapies bind to multiple steroid receptors and are associated with several side-effects. It is thus important to understand the relationship between steroid receptor cross-reactivity and the side-effect profile of progestins. In cell lines that express negligible levels of steroid receptors, we report for the first time the binding affinities, potencies and efficacies of selected progestins from different generations determined in parallel. We show that the progestins bind to the androgen receptor (AR) with similar affinities to each other and progesterone, while none bind estrogen receptor (ER)-β, and only norethisterone acetate, levonorgestrel and gestodene bind ERα...
July 12, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28710978/relationships-between-pops-biometrics-and-circulating-steroids-in-male-polar-bears-ursus-maritimus-from-svalbard
#6
Tomasz M Ciesielski, Ingunn Tjelta Hansen, Jenny Bytingsvik, Martin Hansen, Elisabeth Lie, Jon Aars, Bjørn M Jenssen, Bjarne Styrishave
The aim of this study was to determine the effects of persistent organic pollutants (POPs) and biometric variables on circulating levels of steroid hormones (androgens, estrogens and progestagens) in male polar bears (Ursus maritimus) from Svalbard, Norway (n = 23). Levels of pregnenolone (PRE), progesterone (PRO), androstenedione (AN), dehydroepiandrosterone (DHEA), testosterone (TS), dihydrotestosterone (DHT), estrone (E1), 17α-estradiol (αE2) and 17β-estradiol (βE2) were quantified in polar bear serum by gas chromatography tandem mass spectrometry (GC-MS/MS), while POPs were measured in plasma...
July 12, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28706413/virilization-in-a-postmenopausal-female-due-to-androgen-secreting-ovarian-dermoid-cyst
#7
Murali Subbaiah, Gowri Dorairajan, Debasis Gochhait, G Vijayalakshmi
Virilizing ovarian dermoid cysts are very rare. The source of androgen in these cysts may be tumors such as Sertoli-Leydig cell tumor or Leydig cell hyperplasia. A 52-year-old postmenopausal female with virilization was found to have an ovarian dermoid cyst on ultrasound. Her serum testosterone levels were elevated. Leydig cell hyperplasia within the dermoid cyst was found to be the source of androgen in this patient.
April 2017: Journal of Mid-life Health
https://www.readbyqxmd.com/read/28705923/maternal-and-female-fetal-testosterone-levels-are-associated-with-maternal-age-and-gestational-weight-gain
#8
Theodora Kunovac-Kallak, Charlotte Hellgren, Alkistis Skalkidou, Lotta Sandelin-Francke, Kumari Ubhayasekera, Jonas Bergquist, Ove Axelsson, Erika Comasco, Rebecca Campbell, Inger Sundstrom Poromaa
OBJECTIVE: Prenatal androgen exposure has been suggested to play a role in polycystic ovary syndrome. Given the limited information on what maternal characteristics influence maternal testosterone levels, and the even less explored routes by which female fetus androgen exposure would occur, the aim of this study was to investigate the impact of maternal age, BMI, weight gain, depressed mood, and aromatase SNPs on testosterone levels in maternal serum and amniotic fluid of female fetuses...
July 13, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28696825/androgen-status-in-non-diabetic-elderly-men-with-heart-failure
#9
Goran Loncar, Biljana Bozic, Aleksandar N Neskovic, Natasa Cvetinovic, Mitja Lainscak, Nenad Prodanovic, Hans-Dirk Dungen, Stephan von Haehling, Zoran Radojicic, Tobias Trippel, Biljana Putnikovic, Natasa Markovic-Nikolic, Vera Popovic
PURPOSE: We aimed at evaluating androgen status (serum testosterone [TT] and estimated free testosterone [eFT]) and its determinants in non-diabetic elderly men with heart failure (HF). Additionally, we investigated its associations with body composition and long-term survival. METHODS: Seventy three non-diabetic men with HF and 20 healthy men aged over 55 years were studied. Echocardiography, 6-min walk test, grip strength, body composition measurement by DEXA method were performed...
July 11, 2017: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/28695864/the-role-of-the-serum-testosterone-levels-as-a-predictor-of-prostate-cancer-in-patients-with-atypical-small-acinar-proliferation-at-the-first-prostate-biopsy
#10
Lucio Dell'Atti, Andrea B Galosi
The current literature does not support the usefulness of clinical markers on predicting which patients with atypical small acinar proliferation (ASAP) are more likely to progress to prostate cancer (PCa). Androgens have long been considered to be the potential risk factors for PCa. However, the role of testosterone is controversial. The present study aims to analyze the relationship between serum testosterone (TS) levels and the diagnosis of PCa after a first prostate biopsy in patients affected by ASAP. This retrospective study included 143 patients diagnosed with ASAP in an initial transrectal ultrasound-guided prostate biopsy for suspicious PCa according to the European Association of Urology guidelines...
July 11, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/28692411/evaluation-of-the-health-benefits-of-a-multivitamin-multimineral-herbal-essential-oil-infused-supplement-a-pilot-trial
#11
Xuesheng Han, Dennis L Eggett, Tory L Parker
This study was designed to quantitatively evaluate the health benefits of a multivitamin, multimineral, herbal, essential oil-infused supplement using serum biomarkers. We also qualitatively evaluated the health effects of this supplement using a survey. Sixteen participants were recruited to take the supplement as directed for two months. The levels of the following serum components were measured in the participants: total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, triglycerides, lipoprotein(a), LDL/HDL cholesterol ratio, total/HDL cholesterol ratio, ferritin, fibrinogen, C-reactive protein, insulin, testosterone, sex hormone binding globulin, free androgen index, red blood cell magnesium, homocysteine, coenzyme Q10, lipid peroxides, alpha-tocopherol, gamma-tocopherol, cardiovascular index, eicosapentaenoic acid (EPA), arachidonic acid (AA), and the AA/EPA ratio...
July 10, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/28690989/the-association-between-skeletal-maturation-and-adrenal-androgen-levels-in-obese-children-and-adolescents
#12
Sung Eun Kim, Joon Weon Jang, Moon Bae Ahn, Shin-Hee Kim, Won Kyoung Cho, Kyoung Soon Cho, So Hyun Park, Min Ho Jung, Byoung Kyu Suh
PURPOSE: This study aimed to investigate the association between skeletal maturation and adrenal androgen levels in obese children and adolescents. METHODS: Fifty-three children and adolescents (aged 7-15 years) diagnosed as obese or overweight were investigated. Anthropometric measurements, bone age (BA) determination, serum biochemical analyses, and hormonal measurements were performed. The difference between BA and chronological age (BA-CA, dBACA) was calculated and used to represent the degree of advanced skeletal maturation...
June 2017: Annals of Pediatric Endocrinology & Metabolism
https://www.readbyqxmd.com/read/28686893/a-relationship-in-adrenal-androgen-levels-between-mothers-and-their-children-from-a-dioxin-exposed-region-in-vietnam
#13
Le Thai Anh, Teruhiko Kido, Seijiro Honma, Ho Dung Manh, Ikue Koike, Yuko Oyama, Hoang Duc Phuc, Rie Okamoto, Hideaki Nakagawa, Shoji F Nakayama, Dang Duc Nhu, Nguyen Hung Minh, Ngo Van Toan, Le Ke Son
Over the past decades, southern Vietnam has been burdened by dioxins from contaminated herbicides sprayed during the Vietnam War. In a previous study, we found that dioxin exposure decreased levels of salivary dehydroepiandrosterone (DHEA), an adrenal androgen, in 3-year-old children. In present study, to assess the relationship between adrenal hormones disruption in lactating mothers and in children, we compared mother-child pairs from dioxin- and nondioxin-contaminated regions. In 2010 and 2011, mother-child pairs from a dioxin hotspot region (n=37) and a non-contaminated region (n=47) were recruited and donated breast milk and serum samples for dioxin and steroid hormones determination...
July 4, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28680856/sertoli-cells-are-susceptible-to-zikv-infection-in-mouse-testis
#14
Zi-Yang Sheng, Na Gao, Zhao-Yang Wang, Xiao-Yun Cui, De-Shan Zhou, Dong-Ying Fan, Hui Chen, Pei-Gang Wang, Jing An
Flaviviruses including Dengue virus (DENV), Yellow fever virus (YFV), West Nile virus (WNV), and Japanese encephalitis virus (JEV) are global health problems that caused several serious diseases such as fever, hemorrhagic fever, and encephalitis in the past century. Recently, Zika virus (ZIKV) which spreads from Asia to American and causes millions of infections emerges as a new dangerous member of the genus of Flavivirus. Unlike other well-known flaviviruses, ZIKV can be transmitted sexually and infect testes in murine models...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28673896/serum-androgen-levels-and-their-relation-to-performance-in-track-and-field-mass-spectrometry-results-from-2127-observations-in-male-and-female-elite-athletes
#15
Stéphane Bermon, Pierre-Yves Garnier
OBJECTIVE: To describe and characterise serum androgen levels and to study their possible influence on athletic performance in male and female elite athletes. METHODS: 2127 observations of competition best performances and mass spectrometry-measured serum androgen concentrations, obtained during the 2011 and 2013 International Association of Athletics Federations World Championships, were analysed in male and female elite track and field athletes. To test the influence of serum androgen levels on performance, male and female athletes were classified in tertiles according to their free testosterone (fT) concentration and the best competition results achieved in the highest and lowest fT tertiles were then compared...
July 3, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28669219/the-prevalence-of-non-classic-congenital-adrenal-hyperplasia-due-to-21-hydroxylase-deficiency-in-russian-women-with-hyperandrogenism
#16
Elena Grodnitskaya, Mark Kurtser
The aim of the study was to determine the prevalence of non-classic congenital adrenal hyperplasia (NCAH) due to 21-hydroxylase (21-OH) deficiency among hyperandrogenic women in a Russian population and to evaluate diagnostic value of basal serum 17-hydroxyprogesterone (17-OHP) level to diagnose this disease. A total of 800 consecutive Caucasian women presenting with elevation of at least one serum androgen and/or manifestation of one of the clinical androgenic symptoms were prospectively recruited and evaluated by basal 17-OHP...
July 3, 2017: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/28668858/evaluation-of-bone-turnover-quality-markers-and-bone-mineral-density-in-prostate-cancer-patients-receiving-androgen-deprivation-therapy-with-or-without-denosumab
#17
Yoshiyuki Miyazawa, Yoshitaka Sekine, Takahiro Syuto, Masashi Nomura, Hidekazu Koike, Hiroshi Matsui, Yasuhiro Shibata, Kazuto Ito, Kazuhiro Suzuki
BACKGROUND/AIM: Androgen deprivation therapy (ADT) is a mainstay therapy for prostate cancer (PCa). ADT induces bone loss and increases the risk of osteoporosis and fractures. Recently, loss of bone quality has received attention as a factor that causes loss of bone strength independent of bone mineral density (BMD). Pentosidine has been identified as a surrogate marker of bone quality. Therefore, bone quality markers were evaluated retrospectively in PCa patients receiving ADT with or without denosumab...
July 2017: Anticancer Research
https://www.readbyqxmd.com/read/28663228/testicular-versus-adrenal-sources-of-hydroxyandrogens-in-prostate-cancer
#18
Tianzhu Zang, Mary-Ellen Taplin, Daniel Tamae, Wanling Xie, Clementina Mesaros, Zhenwei Zhang, Glenn J Bubley, Robert Bruce Montgomery, Steven Balk, Elahe Mostaghel, Ian A Blair, Trevor Penning
Neoadjuvant androgen deprivation therapy (NADT) is one strategy for the treatment of early-stage prostate cancer; however, the long-term outcomes of NADT with radical prostatectomy including biochemical failure-free survival are not promising. One proposed mechanism is incomplete androgen ablation. In this study, we aimed to evaluate the efficiency of serum hydroxy-androgen suppression in patients with localized high-risk prostate cancer under NADT (leuprolide acetate plus abiraterone acetate and prednisone) and interrogate the primary sources of circulating hydroxy-androgens using our recently described stable isotope dilution liquid chromatography mass spectrometric method (Zang et al...
June 29, 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/28653944/association-between-serum-25-oh-vitamin-d-and-metabolic-disturbances-in-polycystic-ovary-syndrome
#19
M A Keshavarz, S Moradi, Z Emami, F Rohani
BACKGROUND: To assess the relationship between serum 25(OH) vitamin D levels and metabolic parameters together with androgenic hormone levels in women with polycystic ovary syndrome (PCOS). METHODS: This is a single-centre study from the Endocrinology Institute at Firouzgar Hospital in Iran. Seventy-three women aged 15-45 years were recruited from May 2013 to December 2013. Serum 25(OH) vitamin D level, other laboratory biomarkers and anthropometric indexes were measured...
June 2017: Netherlands Journal of Medicine
https://www.readbyqxmd.com/read/28649885/can-the-source-of-hyperandrogenism-in-adolescents-with-polycystic-ovary-syndrome-predict-metabolic-phenotype
#20
Alaa Al Nofal, Lyndsay D Viers, Asma Javed
In this study, we demonstrated an association between adrenal hyperandrogenism, as determined by dehydroepiandrostenedione-to-free testosterone (DHEA-S/FT) ratio, and metabolic phenotype in obese and lean adolescents with polycystic ovary syndrome (PCOS). We compared 64 overweight/obese adolescents with PCOS (PCOS-O) with 18 lean (PCOS-L) adolescents. We analyzed the association between DHEA-S/FT ratios and metabolic parameters. Patients in the PCOS-O group were younger (median [interquartile range]) than those in the PCOS-L group (15 [15-17] vs...
June 24, 2017: Gynecological Endocrinology
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