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Androgen related genes

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https://www.readbyqxmd.com/read/29656192/in-vitro-bioanalysis-of-drinking-water-from-source-to-tap
#1
Anna Kjerstine Rosenmai, Johan Lundqvist, Théo le Godec, Åsa Ohlsson, Rikard Tröger, Björn Hellman, Agneta Oskarsson
The presence of chemical pollutants in sources of drinking water is a key environmental problem threatening public health. Efficient removal of pollutants in drinking water treatment plants (DWTPs) is needed as well as methods for assessment of the total impact of all present chemicals on water quality. In the present study we have analyzed the bioactivity of water samples from source to tap, including effects of various water treatments in a DWTP, using a battery of cell-based bioassays, covering health-relevant endpoints...
April 6, 2018: Water Research
https://www.readbyqxmd.com/read/29656166/identification-of-molt-inhibiting-hormone-and-ecdysteroid-receptor-cdna-sequences-in-gammarus-pulex-and-variations-after-endocrine-disruptor-exposures
#2
Eric Gismondi
In amphipods, growth, development and reproduction are mediated by the molt, which is a hormonally controlled process and which, therefore, could be impacted by endocrine disruption compounds (EDC). The molt process is controlled by both X-organ (XO) and Y-organ (YO) through a variety of hormones and receptors including the molt-inhibiting hormone (MIH) and the ecdysteroid receptor (EcR). However, although many studies were devoted to characterize MIH and EcR in crustaceans, only few works evaluated their variations under EDCs exposures...
April 12, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29623359/endocrine-disrupting-activities-and-organic-contaminants-associated-with-oil-and-gas-operations-in-wyoming-groundwater
#3
Christopher D Kassotis, Danh C Vu, Phuc H Vo, Chung-Ho Lin, Jennifer N Cornelius-Green, Sharyle Patton, Susan C Nagel
Unconventional oil and natural gas (UOG) operations couple horizontal drilling with hydraulic fracturing to access previously inaccessible fossil fuel deposits. Hydraulic fracturing, a common form of stimulation, involves the high-pressure injection of water, chemicals, and sand to fracture the target layer and release trapped natural gas and/or oil. Spills and/or discharges of wastewater have been shown to impact surface, ground, and drinking water. The goals of this study were to characterize the endocrine activities and measure select organic contaminants in groundwater from conventional oil and gas (COG) and UOG production regions of Wyoming...
April 5, 2018: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/29605576/effects-of-maternal-dietary-selenium-se-enriched-yeast-on-testis-development-testosterone-level-and-testicular-steroidogenesis-related-gene-expression-of-their-male-kids-in-taihang-black-goats
#4
Lei Shi, Ruigao Song, Xiaolei Yao, Yunli Duan, Youshe Ren, Chunxiang Zhang, Wenbin Yue, Fulin Lei
To investigate the effects of maternal dietary selenium (Se-enriched yeast) on testis development, testosterone level and steroidogenesis-related gene expression in testis of their male kids, selected pregnant Taihang Black Goats were randomly allotted to four treatment groups. They were fed the basal gestation and lactation diets supplemented with 0 (control), 0.5, 2.0 and 4.0 mg of Se/kg DM. Thirty days after weaning, testes were collected from the kids. After the morphological development status of testis was examined, tissue samples were collected for analyzing testosterone concentration and histological parameters...
March 26, 2018: Theriogenology
https://www.readbyqxmd.com/read/29584789/the-effect-of-cag-repeats-length-on-differences-in-hirsutism-among-healthy-israeli-women-of-different-ethnicities
#5
Naomi Weintrob, Ori Eyal, Meital Slakman, Anat Segev Becker, Galit Israeli, Ofra Kalter-Leibovici, Shay Ben-Shachar
PURPOSE: Variations in the degree of hirsutism among women of different ethnic backgrounds may stem from multiple etiologies. Shorter length of the polymorphic CAG repeats of the androgen receptor (AR) gene may be associated with increased activity of the receptor leading to hirsutism. We hypothesized that there are ethnic differences in the degree of hirsutism that is unrelated to androgen levels among Israeli women, and that the CAG repeats length may contribute to these differences...
2018: PloS One
https://www.readbyqxmd.com/read/29581838/high-expression-of-slco2b1-is-associated-with-prostate-cancer-recurrence-after-radical-prostatectomy
#6
Tomoaki Terakawa, Eriko Katsuta, Li Yan, Nitesh Turaga, Kerry-Ann McDonald, Masato Fujisawa, Khurshid A Guru, Kazuaki Takabe
Solute carrier organic anion (SLCO) gene families encode organic anion transport proteins, which are transporters that up-take a number of substrates including androgens. Among them, high expression of SLCO2B1 is known to associate with the resistance to androgen deprivation therapy in prostate cancer (PCa). We hypothesized that high expression of SLCO genes enhances PCa progression by promoting the influx of androgen. Here, we demonstrated the impact of the expression levels of SLCO2B1 on prognosis in localized PCa after radical prostatectomy (RP) utilizing 494 PCa cases in The Cancer Genome Atlas (TCGA)...
March 6, 2018: Oncotarget
https://www.readbyqxmd.com/read/29579075/effects-of-pharmacologic-sclerostin-inhibition-or-testosterone-administration-on-soleus-muscle-atrophy-in-rodents-after-spinal-cord-injury
#7
Ean G Phillips, Luke A Beggs, Fan Ye, Christine F Conover, Darren T Beck, Dana M Otzel, Payal Ghosh, Anna C F Bassit, Stephen E Borst, Joshua F Yarrow
Sclerostin is a circulating osteocyte-derived glycoprotein that negatively regulates Wnt-signaling after binding the LRP5/LRP6 co-receptors. Pharmacologic sclerostin inhibition produces bone anabolic effects after spinal cord injury (SCI), however, the effects of sclerostin-antibody (Scl-Ab) on muscle morphology remain unknown. In comparison, androgen administration produces bone antiresorptive effects after SCI and some, but not all, studies have reported that testosterone treatment ameliorates skeletal muscle atrophy in this context...
2018: PloS One
https://www.readbyqxmd.com/read/29575348/the-tempo-of-human-childhood-a-maternal-foot-on-the-accelerator-a-paternal-foot-on-the-brake
#8
Jennifer Kotler, David Haig
Relative to the life history of other great apes, that of humans is characterized by early weaning and short interbirth intervals (IBIs). We propose that in modern humans, birth until adrenarche, or the rise in adrenal androgens, developmentally corresponds to the period from birth until weaning in great apes and ancestral hominins. According to this hypothesis, humans achieved short IBIs by subdividing ancestral infancy into a nurseling phase, during which offspring fed at the breast, and a weanling phase, during which offspring fed specially prepared foods...
March 25, 2018: Evolutionary Anthropology
https://www.readbyqxmd.com/read/29574703/genomic-alterations-in-plasma-dna-from-patients-with-metastasized-prostate-cancer-receiving-abiraterone-or-enzalutamide
#9
Jelena Belic, Ricarda Graf, Thomas Bauernhofer, Yauheniya Cherkas, Peter Ulz, Julie Waldispuehl-Geigl, Samantha Perakis, Michael Gormley, Jaymala Patel, Weimin Li, Jochen B Geigl, Denis Smirnov, Ellen Heitzer, Mitchell Gross, Michael R Speicher
In patients with metastatic castrate resistant prostate cancer (mCRPC), circulating tumor DNA (ctDNA) analysis offers novel opportunities for the development of non-invasive biomarkers informative of treatment response with novel agents targeting the androgen-receptor (AR) pathway, such as abiraterone or enzalutamide. However, the relationship between ctDNA abundance, detectable somatic genomic alterations and clinical progression of mCRPC remains unexplored. Our study aimed to investigate changes in plasma DNA during disease progression and their associations with clinical variables in mCRPC patients...
March 25, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29550552/expression-profiles-of-amhy-and-major-sex-related-genes-during-gonadal-sex-differentiation-and-their-relation-with-genotypic-and-temperature-dependent-sex-determination-in-pejerrey-odontesthes-bonariensis
#10
Yan Zhang, Ricardo S Hattori, Munti Sarida, Estefany C García, Carlos Augusto Strüssmann, Yoji Yamamoto
To shed light on the mechanisms of and interactions of GSD and TSD in pejerrey, we investigated how the transcriptional profiles of amhy and amha are affected by feminizing (17°C) and masculinizing (29°C) temperatures during the critical period of sex determination/differentiation and their relation with the expression profiles of AMH receptor type II (amhrII), gonadal aromatase (cyp19a1a), and 11 beta-hydroxysteroid dehydrogenase 2 (hsd11b2). Careful consideration of the results of this study and all information currently available for this species, including similar analyzes for an intermediate, mixed-sex promoting temperature (25°C), suggests a model for genotypic/temperature-dependent sex determination and gonadal sex differentiation that involves a) cyp19a1a-dependent, developmentally-programmed ovarian development as the default state that becomes self-sustaining in the absence of a potent and timely masculinizing stimulus, b) early, developmentally-programmed amhy expression and high temperature as masculinization signals that antagonize the putative female pathway by suppressing cyp19a1a expression, c) increasing stress response, cortisol, and the synthesis of the masculinizing androgen 11-keto-testosterone via hsd11b2 with increasing temperature that is important for masculinization in both genotypes but particularly so in XX individuals, and d) an endocrine network with positive/negative feedback mechanisms that ensure fidelity of the male/female pathway once started...
March 14, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29545400/inhibition-of-glycolysis-in-prostate-cancer-chemoprevention-by-phenethyl-isothiocyanate
#11
Krishna B Singh, Eun-Ryeong Hahm, Lora H Rigatti, Daniel P Normolle, Jian-Min Yuan, Shivendra V Singh
We have shown previously that dietary administration of phenethyl isothiocyanate (PEITC), a small molecule from edible cruciferous vegetables, significantly decreases the incidence of poorly-differentiated prostate cancer in Transgenic Adenocarcinoma of Mouse Prostate (TRAMP) mice without any side effects. In this study, we investigated the role of c-Myc-regulated glycolysis in prostate cancer chemoprevention by PEITC. Exposure of LNCaP (androgen-responsive) and 22Rv1 (castration-resistant) human prostate cancer cells to PEITC resulted in suppression of expression as well as transcriptional activity of c-Myc...
March 15, 2018: Cancer Prevention Research
https://www.readbyqxmd.com/read/29544963/effects-of-chronic-testosterone-administration-on-the-degree-of-preference-for-a-high-fat-diet-and-body-weight-in-gonadal-intact-and-ovariectomized-female-rats
#12
Takeshi Iwasa, Toshiya Matsuzaki, Kiyohito Yano, Mayila Yiliyasi, Akira Kuwahara, Sumika Matsui, Minoru Irahara
Energy balance and reproductive functions are closely linked in some species. The sex hormones (estrogens and androgens) are involved in the regulation of appetite, metabolism, body weight (BW), and body composition in mammals. Previously, we showed that the effects of testosterone on BW, appetite, and fat weight were markedly affected by alterations to the gonadal hormonal milieu. In this study, we examined whether testosterone administration changes food preferences and whether these effects of testosterone depend on gonadal status in female rats...
March 12, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29544766/molecular-characterization-expression-and-cellular-localization-of-cyp17-gene-during-geese-anser-cygnoides-follicular-development
#13
Huilan Huang, Da Chen, Shenqiang Hu, Jiwen Wang, Hehe Liu, Jiwei Hu, Liang Li
As a key member of the cytochrome P450 gene superfamily, CYP17 gene encodes 17α-hydroxylase/c17-20 lyase that is critical for directing androgen synthesis. The CYP17 gene has been identified in several species, yet little is known about its distribution and expression profile during goose follicular development. In the present study, we obtained the full-length coding sequence of goose CYP17 (gCYP17) gene for the first time using RACE method. Its sequence alignment and phylogenetic analysis suggested that gCYP17 was highly conserved with those of other birds and consisted of four main functional domains like other species...
March 12, 2018: Gene
https://www.readbyqxmd.com/read/29541371/y08060-a-selective-bet-inhibitor-for-treatment-of-prostate-cancer
#14
Qiuping Xiang, Yan Zhang, Jiaguo Li, Xiaoqian Xue, Chao Wang, Ming Song, Cheng Zhang, Rui Wang, Chenchang Li, Chun Wu, Yulai Zhou, Xiaohong Yang, Guohui Li, Ke Ding, Yong Xu
Prostate cancer is a commonly diagnosed cancer and a leading cause of cancer-related deaths. The bromodomain and extra terminal domain (BET) family proteins have emerged as potential therapeutic targets for the treatment of castration-resistant prostate cancer. A series of 2,2-dimethyl-2 H -benzo[ b ][1,4]oxazin-3(4 H )-one derivatives were designed and synthesized as selective bromodomain containing protein 4 (BRD4) inhibitors. The compounds potently inhibit BRD4(1) with nanomolar IC50 values and exhibit high selectivity over most non-BET subfamily members...
March 8, 2018: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29534468/arhgap15-in-human-breast-carcinoma-a-potent-tumor-suppressor-regulated-by-androgens
#15
Kiyoshi Takagi, Yasuhiro Miki, Yoshiaki Onodera, Takanori Ishida, Mika Watanabe, Hironobu Sasano, Takashi Suzuki
Rho GTPase activating protein 15 (ARHGAP15) is a recently identified GTPase activating protein which enhances intrinsic hydrolysis of GTP-bound Ras-related C3 botulinus toxin substrate (Rac1), resulting in inactivation of Rac1. Although a lot of studies have pointed out the pivotal roles of the Rac1 pathway in the progression of breast carcinomas, the clinical significance of ARHGAP15 has remained largely unknown in human breast carcinomas. Therefore, we immunolocalized ARHGAP15 in one hundred breast carcinoma tissues...
March 10, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29531971/bcl-2-and-bcl-xl-expression-are-down-regulated-in-benign-prostate-hyperplasia-nodules-and-not-affected-by-finasteride-and-or-celecoxib
#16
Feng Li, Laura E Pascal, Jianhua Zhou, Yibin Zhou, Ke Wang, Anil V Parwani, Rajiv Dhir, Peng Guo, Dalin He, Joel B Nelson, Zhou Wang
The mechanisms involved in the development of benign prostatic hyperplasia (BPH) are poorly understood. One potential mechanism involved in BPH pathogenesis may involve altered expression of genes related to apoptosis and proliferation because reduced cell death and increased proliferation are thought to contribute to prostatic enlargement. This study examined the expression of B-cell lymphoma 2 (BCL-2) and B-cell lymphoma-extra large (BCL-XL), two important anti-apoptosis factors that are also capable of inhibiting cell proliferation via accelerated G1 arrest or delayed G1/S transition, using immunostaining in simple prostatectomy BPH specimens from patients naïve to androgen manipulation...
2018: American Journal of Clinical and Experimental Urology
https://www.readbyqxmd.com/read/29530537/effect-based-monitoring-of-the-danube-river-using-mobile-passive-sampling
#17
Jiří Novák, Branislav Vrana, Tatsiana Rusina, Krzysztof Okonski, Roman Grabic, Peta A Neale, Beate I Escher, Miroslava Macová, Selim Ait-Aissa, Nicolas Creusot, Ian Allan, Klára Hilscherová
Many aquatic pollutants can be present at low concentrations, but their mixtures can still affect health or behavior of exposed organisms. In this study, toxicological and chemical analyses were combined for spatial contamination profiling using an innovative passive sampling approach. A novel Dynamic Passive Sampler (DPS) was employed as a mobile sampler from a ship cruising along 2130km of the Danube river during the Joint Danube Survey 3 (JDS3). The sampling was performed in eight subsequent river stretches with two types of complementary passive samplers: silicone rubber sheets (SR) used for non-polar chemicals and SDB-RPS Empore™ disks (ED) for more hydrophilic compounds...
March 9, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29503661/identification-of-shared-molecular-signatures-indicate-the-susceptibility-of-endometriosis-to-multiple-sclerosis
#18
Amit Katiyar, Sujata Sharma, Tej P Singh, Punit Kaur
Women with endometriosis (EMS) appear to be at a higher risk of developing other autoimmune diseases predominantly multiple sclerosis (MS). Though EMS and MS are evidently diverse in their phenotype, they are linked by a common autoimmune condition or immunodeficiency which could play a role in the expansion of endometriosis and possibly increase the risk of developing MS in women with EMS. However, the common molecular links connecting EMS with MS are still unclear. We conducted a meta-analysis of microarray experiments focused on EMS and MS with their respective controls...
2018: Frontiers in Genetics
https://www.readbyqxmd.com/read/29501522/combined-treatment-with-melatonin-and-insulin-improves-glycemic-control-white-adipose-tissue-metabolism-and-reproductive-axis-of-diabetic-male-rats
#19
Ariclecio Cunha de Oliveira, Sandra Andreotti, Rogério António Laurato Sertie, Amanda Baron Campana, André Ricardo Gomes de Proença, Renata Prado Vasconcelos, Keciany Alves de Oliveira, Andrelina Noronha Coelho-de-Souza, José Donato Junior, Fábio Bessa Lima
AIMS: Melatonin treatment has been reported to be capable of ameliorating metabolic diabetes-related abnormalities but also to cause hypogonadism in rats. We investigated whether the combined treatment with melatonin and insulin can improve insulin resistance and other metabolic disorders in rats with streptozotocin-induced diabetes during neonatal period and the repercussion of this treatment on the hypothalamic-pituitary-gonadal axis. MAIN METHODS: At the fourth week of age, diabetic animals started an 8-wk treatment with only melatonin (0...
February 28, 2018: Life Sciences
https://www.readbyqxmd.com/read/29500952/individual-differences-in-developmental-plasticity-a-role-for-early-androgens
#20
REVIEW
Marco Del Giudice, Emily S Barrett, Jay Belsky, Sarah Hartman, Michelle M Martel, Susanne Sangenstedt, Christopher W Kuzawa
Developmental plasticity is a widespread property of living organisms, but different individuals in the same species can vary greatly in how susceptible they are to environmental influences. In humans, research has sought to link variation in plasticity to physiological traits such as stress reactivity, exposure to prenatal stress-related hormones such as cortisol, and specific genes involved in major neurobiological pathways. However, the determinants of individual differences in plasticity are still poorly understood...
February 23, 2018: Psychoneuroendocrinology
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