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https://www.readbyqxmd.com/read/29663951/active-case-finding-and-treatment-adherence-in-risk-groups-in-the-tuberculosis-pre-elimination-era
#1
R K Gupta, M Lipman, A Story, A Hayward, G de Vries, R van Hest, C Erkens, M X Rangaka, I Abubakar
Vulnerable populations, including homeless persons, high-risk drug and alcohol users, prison inmates and other marginalised populations, contribute a disproportionate burden of tuberculosis (TB) cases in low-incidence settings. Drivers of this disease burden include an increased risk of both TB transmission in congregate settings, and progression from infection to active disease. Late diagnosis and poor treatment completion further propagate the epidemic and fuel the acquisition of drug resistance. These groups are therefore a major priority for TB control programmes in low-incidence settings...
May 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29661680/individual-level-key-associations-and-modes-of-exposure-for-hepatitis-c-virus-infection-in-the-middle-east-and-north-africa-a-systematic-synthesis
#2
Sarwat Mahmud, Silva P Kouyoumjian, Zaina Al Kanaani, Hiam Chemaitelly, Laith J Abu-Raddad
PURPOSE: To identify, map, and synthesize the individual-level key associations and modes of exposure for hepatitis C virus (HCV) infection in the Middle East and North Africa (MENA), the most affected region by HCV. METHODS: Source of data was the MENA HCV Epidemiology Synthesis Project database, populated through systematic literature searches. Risk factors determined to be statistically significant after adjustment for confounders were extracted and categorized into key associations or modes of exposure...
March 21, 2018: Annals of Epidemiology
https://www.readbyqxmd.com/read/29653253/cholesterol-and-bile-acid-mediated-regulation-of-autophagy-in-fatty-liver-diseases-and-atherosclerosis
#3
REVIEW
Yifeng Wang, Wen-Xing Ding, Tiangang Li
Liver is the major organ that regulates whole body cholesterol metabolism. Disrupted hepatic cholesterol homeostasis contributes to the pathogenesis of nonalcoholic steatohepatitis, dyslipidemia, atherosclerosis, and cardiovascular diseases. Hepatic bile acid synthesis is the major catabolic mechanism for cholesterol elimination from the body. Furthermore, bile acids are signaling molecules that regulate liver metabolism and inflammation. Autophagy is a highly-conserved lysosomal degradation mechanism, which plays an essential role in maintaining cellular integrity and energy homeostasis...
April 10, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29651418/role-of-the-sympathetic-nervous-system-and-its-modulation-in-renal-hypertension
#4
REVIEW
Yusuke Sata, Geoffrey A Head, Kate Denton, Clive N May, Markus P Schlaich
The kidneys are densely innervated with renal efferent and afferent nerves to communicate with the central nervous system. Innervation of major structural components of the kidneys, such as blood vessels, tubules, the pelvis, and glomeruli, forms a bidirectional neural network to relay sensory and sympathetic signals to and from the brain. Renal efferent nerves regulate renal blood flow, glomerular filtration rate, tubular reabsorption of sodium and water, as well as release of renin and prostaglandins, all of which contribute to cardiovascular and renal regulation...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29624979/inappropriate-prescribing-in-older-adults-critical-review-of-the-literature-and-safety-alerts
#5
Dolores Mino-León, María Eugenia Galván-Plata, Anda-Garay Anda-GarayJuan Carlos, Maura Estela Noyola-García, Davis Cooper
Background: Prescribing errors are a risk factor for patients to present adverse events and a strategy that has been incorporated into medical care to reduce them is the use of computer tools. The objective was to obtain the scientific basis for the development of prescribing error alerts for four chronic diseases with a higher prevalence in population ≥ 65 years. Methods: We reviewed the literature from 2010 to 2015 to obtain information about adverse events and adverse drug reactions associated with the use of drugs for the treatment of diabetes mellitus type 2 (DM2), hypertension, osteoarticular diseases (OD) and depression; the review included these databases: PubMed, OVID, Cochrane Library, LILACS, MEDES, Portal Mayores and SIETES...
2018: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/29623483/genome-instability-syndromes-caused-by-impaired-dna-repair-and-aberrant-dna-damage-responses
#6
REVIEW
Takeshi Terabayashi, Katsuhiro Hanada
Maintenance of genome integrity is essential for all organisms because genome information regulates cell proliferation, growth arrest, and vital metabolic processes in cells, tissues, organs, and organisms. Because genomes are constantly exposed to intrinsic and extrinsic genotoxic stress, cellular DNA repair machinery and proper DNA damage responses (DDR) have evolved to quickly eliminate genotoxic DNA lesions, thus maintaining the genome integrity suitably. In human, germline mutations in genes involved not only in cellular DNA repair pathways but also in cellular DDR machinery frequently predispose hereditary diseases associated with chromosome aberrations...
April 5, 2018: Cell Biology and Toxicology
https://www.readbyqxmd.com/read/29618972/an-inflammation-centric-view-of-neurological-disease-beyond-the-neuron
#7
REVIEW
Stephen D Skaper, Laura Facci, Morena Zusso, Pietro Giusti
Inflammation is a complex biological response fundamental to how the body deals with injury and infection to eliminate the initial cause of cell injury and effect repair. Unlike a normally beneficial acute inflammatory response, chronic inflammation can lead to tissue damage and ultimately its destruction, and often results from an inappropriate immune response. Inflammation in the nervous system ("neuroinflammation"), especially when prolonged, can be particularly injurious. While inflammation per se may not cause disease, it contributes importantly to disease pathogenesis across both the peripheral (neuropathic pain, fibromyalgia) and central [e...
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29618086/inflammatory-phenotypes-in-the-intestine-of-poultry-not-all-inflammation-is-created-equal
#8
Michael H Kogut, Kenneth J Genovese, Christina L Swaggerty, Haiqi He, Leon Broom
The intestinal tract harbors a diverse community of microbes that have co-evolved with the host immune system. Although many of these microbes execute functions that are critical for host physiology, the host immune system must control the microbial community so that the dynamics of this interdependent relationship is maintained. To facilitate host homeostasis, the immune system ensures that the microbial load is tolerated, but anatomically contained, while remaining reactive to microbial invasion. Inflammation is the most prevalent manifestation of host defense in reaction to alterations in tissue homeostasis and is elicited by innate immune receptors that recognize and detect infection, host damage, and danger signaling molecules that activate a highly regulated network of immunological and physiological events for the purpose of maintaining homeostasis and restoring functionality...
March 30, 2018: Poultry Science
https://www.readbyqxmd.com/read/29615331/a-novel-wall-water-system-for-cardiopulmonary-bypass-may-reduce-the-risk-of-aerosolized-infection
#9
Gregory S Matte, Thomas J Sandora, Robert J Howe, William L Regan, Gail Potter-Bynoe, James R Neal, Pedro J Del Nido
OBJECTIVE: Oxygenators for cardiopulmonary bypass require water flow for their integral heat exchanger. Heater-cooler units are nearly universally used for this requirement. Heater-cooler units pose the risk of aerosolized infection. The Centers for Disease Control and Prevention recommended discontinuing use of Stöckert 3T heater-cooler units (LivaNova PLC, London, United Kingdom) in October 2016 because of this risk. We aimed to reduce the risk of aerosolized infection posed by heater-cooler units by eliminating those devices from our operating rooms...
March 7, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29615090/adolescent-mental-health-education-inscied-out-a-case-study-of-an-alternative-middle-school-population
#10
Joanna Yang, Roberto Lopez Cervera, Susannah J Tye, Stephen C Ekker, Chris Pierret
BACKGROUND: Mental illness contributes substantially to global disease burden, particularly when illness onset occurs during youth and help-seeking is delayed and/or limited. Yet, few mental health promotion interventions target youth, particularly those with or at high risk of developing mental illness ("at-risk" youth). Community-based translational research has the capacity to identify and intervene upon barriers to positive health outcomes. This is especially important for integrated care in at-risk youth populations...
April 3, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29610725/guidance-and-self-sorting-of-active-swimmers-3d-periodic-arrays-increase-persistence-length-of-human-sperm-selecting-for-the-fittest
#11
Thiruppathiraja Chinnasamy, James L Kingsley, Fatih Inci, Paul J Turek, Mitchell P Rosen, Barry Behr, Erkan Tüzel, Utkan Demirci
Male infertility is a reproductive disease, and existing clinical solutions for this condition often involve long and cumbersome sperm sorting methods, including preprocessing and centrifugation-based steps. These methods also fall short when sorting for sperm free of reactive oxygen species, DNA damage, and epigenetic aberrations. Although several microfluidic platforms exist, they suffer from structural complexities, i.e., pumps or chemoattractants, setting insurmountable barriers to clinical adoption. Inspired by the natural filter-like capabilities of the female reproductive tract for sperm selection, a model-driven design, featuring pillar arrays that efficiently and noninvasively isolate highly motile and morphologically normal sperm, with lower epigenetic global methylation, from raw semen, is presented...
February 2018: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/29609627/trends-in-spatio-temporal-dynamics-of-visceral-leishmaniasis-cases-in-a-highly-endemic-focus-of-bihar-india-an-investigation-based-on-gis-tools
#12
Rakesh Mandal, Shreekant Kesari, Vijay Kumar, Pradeep Das
BACKGROUND: Visceral leishmaniasis (VL) in Bihar State (India) continues to be endemic, despite the existence of effective treatment and a vector control program to control disease morbidity. A clear understanding of spatio-temporal distribution of VL may improve surveillance and control implementation. This study explored the trends in spatio-temporal dynamics of VL endemicity at a meso-scale level in Vaishali District, based on geographical information systems (GIS) tools and spatial statistical analysis...
April 2, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29608128/prenatal-and-postnatal-mother-to-child-transmission-of-acculturation-s-health-effects-in-hispanic-americans
#13
Molly Fox, Zaneta M Thayer, Isabel F Ramos, Sarah J Meskal, Pathik D Wadhwa
BACKGROUND: Hispanic Americans consistently exhibit an intergenerational increase in the prevalence of many noncommunicable chronic physical and mental disorders. METHODS: We review and synthesize evidence suggesting that a constellation of prenatal and postnatal factors may play crucial roles in explaining this trend. We draw from relevant literature across several disciplines, including epidemiology, anthropology, psychology, medicine (obstetrics, neonatology), and developmental biology...
April 2, 2018: Journal of Women's Health
https://www.readbyqxmd.com/read/29563241/measles-outbreak-response-decision-making-under-uncertainty-a-retrospective-analysis
#14
Christopher J Fonnesbeck, Katriona Shea, Spencer Carran, Jose Cassio de Moraes, Christopher Gregory, James L Goodson, Matthew J Ferrari
Resurgent outbreaks of vaccine-preventable diseases that have previously been controlled or eliminated have been observed in many settings. Reactive vaccination campaigns may successfully control outbreaks but must necessarily be implemented in the face of considerable uncertainty. Real-time surveillance may provide critical information about at-risk population and optimal vaccination targets, but may itself be limited by the specificity of disease confirmation. We propose an integrated modelling approach that synthesizes historical demographic and vaccination data with real-time outbreak surveillance via a dynamic transmission model and an age-specific disease confirmation model...
March 2018: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/29560831/spsnet-subpopulation-sensitive-network-based-analysis-of-heterogeneous-gene-expression-data
#15
Abha Belorkar, Rajanikanth Vadigepalli, Limsoon Wong
BACKGROUND: Transcriptomic datasets often contain undeclared heterogeneity arising from biological variation such as diversity of disease subtypes, treatment subgroups, time-series gene expression, nested experimental conditions, as well as technical variation due to batch effects, platform differences in integrated meta-analyses, etc. However, current analysis approaches are primarily designed to handle comparisons between experimental conditions represented by homogeneous samples, thus precluding the discovery of underlying subphenotypes...
March 19, 2018: BMC Systems Biology
https://www.readbyqxmd.com/read/29558850/respecting-the-privacy-of-hospitalized-patients-an-integrative-review
#16
Tayebeh Hasan Tehrani, Sadat Seyed Bagher Maddah, Masoud Fallahi-Khoshknab, Abbas Ebadi, Farahnaz Mohammadi Shahboulaghi, Mark Gillespie
BACKGROUND: Privacy is a complicated and obscure concept, which has special meanings in the healthcare environment; therefore, it is essential for healthcare providers to fully understand this concept. However, there is no universally accepted definition for this concept in the texts, and it has been interpreted differently, based on its application. AIM: To analyze and provide a clear and scientific definition for respect of privacy of hospitalized patients and identify the common aspects of this concept...
January 1, 2018: Nursing Ethics
https://www.readbyqxmd.com/read/29549364/mapping-road-network-communities-for-guiding-disease-surveillance-and-control-strategies
#17
Emanuele Strano, Matheus P Viana, Alessandro Sorichetta, Andrew J Tatem
Human mobility is increasing in its volume, speed and reach, leading to the movement and introduction of pathogens through infected travelers. An understanding of how areas are connected, the strength of these connections and how this translates into disease spread is valuable for planning surveillance and designing control and elimination strategies. While analyses have been undertaken to identify and map connectivity in global air, shipping and migration networks, such analyses have yet to be undertaken on the road networks that carry the vast majority of travellers in low and middle income settings...
March 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29548787/inefficiencies-of-over-screening-and-under-screening-for-cervical-cancer-prevention-in-the-u-s
#18
Philip E Castle, Cosette M Wheeler, Nicole G Campos, Stephen Sy, Emily A Burger, Jane J Kim
There is limited information on the cost-inefficiencies of non-adherence to recommended cervical cancer screening or the potential value for improving non-adherence. We estimated the incremental value of adhering to recommended screening every three years with cytology, using a disease simulation model that integrated real-world screening practice data from New Mexico. The amount that can be spent to improve adherence was estimated by calculating the incremental net monetary benefit (INMB) under scenarios of Current Practice (assuming a population of mixed adherence) and Uniformly Non-Adherent populations with imperfect or perfect adherence to follow-up of screen-positive women...
March 14, 2018: Preventive Medicine
https://www.readbyqxmd.com/read/29533788/biomaterial-scaffolds-for-non-invasive-focal-hyperthermia-as-a-potential-tool-to-ablate-metastatic-cancer-cells
#19
Francisco Pelaez, Navid Manuchehrabadi, Priyatanu Roy, Harishankar Natesan, Yiru Wang, Emilian Racila, Heather Fong, Kevin Zeng, Abby M Silbaugh, John C Bischof, Samira M Azarin
Currently, there are very few therapeutic options for treatment of metastatic disease, as it often remains undetected until the burden of disease is too high. Microporous poly(ε-caprolactone) biomaterials have been shown to attract metastasizing breast cancer cells in vivo early in tumor progression. In order to enhance the therapeutic potential of these scaffolds, they were modified such that infiltrating cells could be eliminated with non-invasive focal hyperthermia. Metal disks were incorporated into poly(ε-caprolactone) scaffolds to generate heat through electromagnetic induction by an oscillating magnetic field within a radiofrequency coil...
February 28, 2018: Biomaterials
https://www.readbyqxmd.com/read/29512106/crispr-cas9-based-genome-editing-of-human-induced-pluripotent-stem-cells
#20
Joseph C Giacalone, Tasneem P Sharma, Erin R Burnight, John F Fingert, Robert F Mullins, Edwin M Stone, Budd A Tucker
Human induced pluripotent stem cells (hiPSCs) are the ideal cell source for autologous cell replacement. However, for patients with Mendelian diseases, genetic correction of the original disease-causing mutation is likely required prior to cellular differentiation and transplantation. The emergence of the CRISPR-Cas9 system has revolutionized the field of genome editing. By introducing inexpensive reagents that are relatively straightforward to design and validate, it is now possible to correct genetic variants or insert desired sequences at any location within the genome...
February 28, 2018: Current Protocols in Stem Cell Biology
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