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https://www.readbyqxmd.com/read/28344695/are-we-adequately-preparing-the-next-generation-of-physicians-to-prescribe-exercise-as-prevention-and-treatment-residents-express-the-desire-for-more-training-in-exercise-prescription
#1
Kara Solmundson, Michael Koehle, Donald McKenzie
BACKGROUND: Physical activity (PA) is a key intervention for chronic disease, yet few physicians provide exercise prescription (EP). EP is an important component in larger strategies of reducing non-communicable disease (NCD). Our objective was to assess Family Medicine Residents (FMR) knowledge, competence, and perspectives of EP to help inform future curriculum development. METHODS: A 49-item cross-sectional survey was administered to 396 University of British Columbia FMR...
October 2016: Canadian Medical Education Journal
https://www.readbyqxmd.com/read/28337689/managing-chronic-pain-in-primary-care-it-really-does-take-a-village
#2
Karen Seal, William Becker, Jennifer Tighe, Yongmei Li, Tessa Rife
Some healthcare systems are relieving primary care providers (PCPs) of "the burden" of managing chronic pain and opioid prescribing, instead offloading chronic pain management to pain specialists. Last year the Centers for Disease Control and Prevention recommended a biopsychosocial approach to pain management that discourages opioid use and promotes exercise therapy, cognitive behavioral therapy and non-opioid medications as first-line patient-centered, multi-modal treatments best delivered by an interdisciplinary team...
March 23, 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/28333835/zero-preventable-deaths-after-traumatic-injury-an-achievable-goal
#3
Philip C Spinella
Preventable deaths after injury must be reduced to improve outcomes for trauma patients. The elimination of preventable deaths after injury has been documented by the 75th US Army Ranger Regiment. Therefore, zero preventable deaths after injury is an achievable goal. Trauma is the most common cause of death between the ages of 1-46 and is the most common cause of life-years lost, before 75 years of age, compared to all other etiologies. Traumatic Hemorrhagic Shock (THS) is the leading cause of death that is preventable after injury, accounting for potentially 17,000 preventable deaths per year in the US...
March 22, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28330510/an-integrated-environmental-improvement-of-marshlands-impact-on-control-and-elimination-of-schistosomiasis-in-marshland-regions-along-the-yangtze-river-china
#4
Le-Ping Sun, Wei Wang, Yin-Ping Zuo, Zheng-Qiu Zhang, Qing-Biao Hong, Guo-Jing Yang, Hong-Ru Zhu, You-Sheng Liang, Hai-Tao Yang
BACKGROUND: Schistosomiasis is a global snail-transmitted infectious disease of poverty. Transmission control had been achieved in China in 2015 after the control efforts for over 60 years. Currently, the remaining core regions endemic for Schistosoma japonicum are mainly located in the marshland and lake regions along the Yangtze River basin. METHODS: During the period from 2001 through 2015, an integrated environmental improvement of the marshlands was carried out through the implementation of industrial, agricultural and resources development projects in Yizheng County along the Yangtze River...
March 22, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28316625/microbiological-study-of-cast-posts-before-cementation
#5
Maricela Vallejo-Labrada, Juan Carlos Ojeda-Garces
This study identifies the most common microorganisms present in type III gold cast posts related to pulpal disease and evaluates the sterilization/disinfection method before cementation in the root canal. Forty-five type III gold cast posts were aseptically collected in sterile sealed plastic bags and taken to the microbiology laboratory to carry out the study: fifteen cast posts had no treatment, fifteen were disinfected (immersion in 70% alcohol during 15 minutes), and fifteen were autoclaved at 121°C for 15 minutes by using saturated steam under 15 psi pressure...
2017: International Journal of Dentistry
https://www.readbyqxmd.com/read/28301480/management-and-modeling-approaches-for-controlling-raccoon-rabies-the-road-to-elimination
#6
REVIEW
Stacey A Elmore, Richard B Chipman, Dennis Slate, Kathryn P Huyvaert, Kurt C VerCauteren, Amy T Gilbert
Rabies is an ancient viral disease that significantly impacts human and animal health throughout the world. In the developing parts of the world, dog bites represent the highest risk of rabies infection to people, livestock, and other animals. However, in North America, where several rabies virus variants currently circulate in wildlife, human contact with the raccoon rabies variant leads to the highest per capita population administration of post-exposure prophylaxis (PEP) annually. Previous rabies variant elimination in raccoons (Canada), foxes (Europe), and dogs and coyotes (United States) demonstrates that elimination of the raccoon variant from the eastern US is feasible, given an understanding of rabies control costs and benefits and the availability of proper tools...
March 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28296281/understanding-african-swine-fever-infection-dynamics-in-sardinia-using-a-spatially-explicit-transmission-model-in-domestic-pig-farms
#7
L Mur, J M Sánchez-Vizcaíno, E Fernández-Carrión, C Jurado, S Rolesu, F Feliziani, A Laddomada, B Martínez-López
African swine fever virus (ASFV) has been endemic in Sardinia since 1978, resulting in severe losses for local pig producers and creating important problems for the island's veterinary authorities. This study used a spatially explicit stochastic transmission model followed by two regression models to investigate the dynamics of ASFV spread amongst domestic pig farms, to identify geographic areas at highest risk and determine the role of different susceptible pig populations (registered domestic pigs, non-registered domestic pigs [brado] and wild boar) in ASF occurrence...
March 13, 2017: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/28292327/approaches-being-used-in-the-national-schistosomiasis-elimination-programme-in-china-a-review
#8
REVIEW
Le-Ping Sun, Wei Wang, Qing-Biao Hong, Shi-Zhu Li, You-Sheng Liang, Hai-Tao Yang, Xiao-Nong Zhou
Schistosomiasis japonica, caused by the human blood fluke Schistosoma japonicum, remains a major public health problem in China, although great success has been achieved. The control efforts during the past half-decade, notably the wide implementation of the new integrated strategy with emphasis on control of the source of S. japonicum infection across the country since 2004, has greatly reduced S. japonicum in humans, livestock, and intermediate host Oncomelania hupensis snails, and transmission control of schistosomiasis was achieved in China in 2015...
March 15, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28283033/resting-and-feeding-preferences-of-anopheles-stephensi-in-an-urban-setting-perennial-for-malaria
#9
Shalu Thomas, Sangamithra Ravishankaran, N A Johnson Amala Justin, Aswin Asokan, Manu Thomas Mathai, Neena Valecha, Jacqui Montgomery, Matthew B Thomas, Alex Eapen
BACKGROUND: The Indian city of Chennai is endemic for malaria and the known local malaria vector is Anopheles stephensi. Plasmodium vivax is the predominant malaria parasite species, though Plasmodium falciparum is present at low levels. The urban ecotype of malaria prevails in Chennai with perennial transmission despite vector surveillance by the Urban Malaria Scheme (UMS) of the National Vector Borne Disease Control Programme (NVBDCP). Understanding the feeding and resting preferences, together with the transmission potential of adult vectors in the area is essential in effective planning and execution of improved vector control measures...
March 10, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28281653/nix-restores-mitophagy-and-mitochondrial-function-to-protect-against-pink1-parkin-related-parkinson-s-disease
#10
Brianada Koentjoro, Jin-Sung Park, Carolyn M Sue
Therapeutic targets are needed to develop neuroprotective treatments for Parkinson's disease (PD). Mitophagy, the selective autophagic elimination of dysfunctional mitochondria, is essential for the maintenance of mitochondrial integrity and is predominantly regulated by the PINK1/Parkin-mediated pathway. Loss of function mutations in Parkin and PINK1 cause an accumulation of dysfunctional mitochondria, leading to nigral neurodegeneration and early-onset PD with a high penetrance rate. We previously identified an asymptomatic homozygous Parkin mutation carrier who had not developed PD by her eighth decade despite the loss of functional Parkin...
March 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28276309/analysis-of-microrna-mrna-interactions-in-stem-cell-enriched-fraction-of-oral-squamous-cell-carcinoma
#11
Vinitha Richard, Rajesh Raju, Aswathy Mary Paul, Reshmi Girijadevi, Thankayyan Retnabai Santhoshkumar, Madhavan Radhakrishna Pillai
This study is an integrated analysis of the transcriptome profile, MicroRNA (miRNA) and their experimentally validatedmRNA targets differentially expressed in the tumorigenic stem-like fraction of oral squamous cell carcinoma (OSCC). We had previously reported the co-existence of multiple drug resistant, tumorigenic fractions termed as side population (SP1, SP2 and MP2) and a non-tumorigenic fraction, main population (MP1) in oral cancer. These fractions displayed self-renewal, regeneration potential and expressed known stemness related cell surface markers despite functional differences...
March 9, 2017: Oncology Research
https://www.readbyqxmd.com/read/28266580/cre-lox-recombinase-mediated-cassette-exchange-for-reversible-site-specific-genomic-targeting-of-the-disease-vector-aedes-aegypti
#12
Irina Häcker, Robert A Harrell Ii, Gerrit Eichner, Kristina L Pilitt, David A O'Brochta, Alfred M Handler, Marc F Schetelig
Site-specific genome modification (SSM) is an important tool for mosquito functional genomics and comparative gene expression studies, which contribute to a better understanding of mosquito biology and are thus a key to finding new strategies to eliminate vector-borne diseases. Moreover, it allows for the creation of advanced transgenic strains for vector control programs. SSM circumvents the drawbacks of transposon-mediated transgenesis, where random transgene integration into the host genome results in insertional mutagenesis and variable position effects...
March 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28264763/peptidoglycan-sensing-by-octopaminergic-neurons-modulates-drosophila-oviposition
#13
C Leopold Kurz, Bernard Charroux, Delphine Chaduli, Annelise Viallat-Lieutaud, Julien Royet
As infectious diseases pose a threat to host integrity, eukaryotes have evolved mechanisms to eliminate pathogens. In addition to develop strategies reducing infection, animals can engage in behaviors that lower the impact of the infection. The molecular mechanisms by which microbes impact host behavior are not well understood. We demonstrate that bacterial infection of Drosophila females reduces oviposition and that peptidoglycan, the component that activates Drosophila antibacterial response, is also the elicitor of this behavioral change...
March 7, 2017: ELife
https://www.readbyqxmd.com/read/28260529/implementing-a-vector-surveillance-response-system-for-chagas-disease-control-a-4-year-field-trial-in-nicaragua
#14
Kota Yoshioka, Doribel Tercero, Byron Pérez, Jiro Nakamura, Lenin Pérez
BACKGROUND: Chagas disease is one of the neglected tropical diseases (NTDs). International goals for its control involve elimination of vector-borne transmission. Central American countries face challenges in establishing sustainable vector control programmes, since the main vector, Triatoma dimidiata, cannot be eliminated. In 2012, the Ministry of Health in Nicaragua started a field test of a vector surveillance-response system to control domestic vector infestation. This paper reports the main findings from this pilot study...
March 6, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28256380/the-cursed-duet-today-tuberculosis-and-hiv-coinfection
#15
Simon Tiberi, Anna Cristina C Carvalho, Giorgia Sulis, Devan Vaghela, Adrian Rendon, Fernanda C de Q Mello, Ananna Rahman, Nashaba Matin, Ali Zumla, Emanuele Pontali
The tuberculosis (TB) and HIV syndemic continues to rage and are a major public health concern worldwide. This deadly association raises complexity and represent a significant barrier towards TB elimination. TB continues to be the leading cause of death amongst HIV-infected people. This paper reports the challenges that lay ahead and outlines some of the current and future strategies that may be able to address this co-epidemic efficiently. Improved diagnostics, cheaper and more effective drugs, shorter treatment regimens for both drug-sensitive and drug-resistant TB are discussed...
February 27, 2017: La Presse Médicale
https://www.readbyqxmd.com/read/28248030/-interferon-in-combined-therapy-of-human-papillomavirus-infections-associated-with-sexually-transmitted-infections-linical-observation
#16
M R Rakhmatulina, N V Bolshenko
To investigate the effectiveness of Ingaron (interferon-) in the treatment of HPV infection associated with sexually transmitted infections, the authors analyzed the scientific literature on the association of human papillomavirus infection with other viral and microbial pathogens. A clinical case of the association of human papillomavirus infection, urogenital infections (urogenital chlamydia and genital herpes) and localized scleroderma penis is described. The results of integrated therapy of diseases with the help of Interferon-gamma have been presented...
November 2016: Urologii︠a︡
https://www.readbyqxmd.com/read/28246273/added-value-of-serum-hormone-measurements-in-risk-prediction-models-for-breast-cancer-for-women-not-using-exogenous-hormones-results-from-the-epic-cohort
#17
Anika Husing, Renee T Fortner, Tilman Kuhn, Kim Overvad, Anne Tjonneland, Anja Olsen, Marie-Christine Boutron-Ruault, Gianluca Severi, Agnes Fournier, Heiner Boeing, Antonia Trichopoulou, Vassiliki Benetou, Philippos Orfanos, Giovanna Masala, Valeria Pala, Rosario Tumino, Francesca Fasanelli, Salvatore Panico, H Bas Bueno-de-Mesquita, Petra Peeters, Carla H van Gils, J Ramon Quiros, Antonio Agudo, Maria-Jose Sanchez, Maria-Dolores Chirlaque, Aurelio Barricarte, Pilar Amiano, Kay-Tee Khaw, Ruth C Travis, Laure Dossus, Kuanrong Li, Pietro Ferrari, Melissa A Merritt, Ioanna Tzoulaki, Elio Riboli, Rudolf Kaaks
PURPOSE: Circulating hormone concentrations are associated with breast cancer risk, with well-established associations for postmenopausal women. Biomarkers may represent minimally invasive measures to improve risk prediction models. EXPERIMENTAL DESIGN: We evaluated improvements in discrimination gained by adding serum biomarker concentrations to risk estimates derived from risk prediction models developed by Gail et al. and Pfeiffer et al. using a nested case-control study within the EPIC cohort including 1217 breast cancer cases and 1976 matched controls...
February 28, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28243183/multidisciplinary-management-of-sexual-dysfunction-perineal-pain-and-elimination-dysfunction-in-a-woman-with-multiple-sclerosis
#18
Michela Miletta, Fabrizio Bogliatto, Leonardo Bacchio
BACKGROUND: Multiple sclerosis (MS) is a chronic disease that commonly affects young women and is associated with sexual dysfunction (SD) and lower anourogenital dysfunction, which affect quality of life. We evaluated the importance of an integrated multidisciplinary approach in the Lower Female Ano-Uro-Genital Network (LFAUGN) to manage a variety of complex symptoms. METHODS: A 40-year-old woman with MS and primary concerns about perineal pain and SD was treated by a trained midwife from the LFAUGN and a physical therapist after a multidisciplinary diagnostic process that included gynecologic evaluation for perineal pain and SD, physiatric assessment, urologic assessment for bladder retention (BR), and surgical examination for obstructed defecation syndrome (ODS)...
January 2017: International Journal of MS Care
https://www.readbyqxmd.com/read/28237835/integration-of-a-cd19-car-into-the-tcr-alpha-chain-locus-streamlines-production-of-allogeneic-gene-edited-car-t-cells
#19
Daniel T MacLeod, Jeyaraj Antony, Aaron J Martin, Rachel J Moser, Armin Hekele, Keith J Wetzel, Audrey E Brown, Melissa A Triggiano, Jo Ann Hux, Christina D Pham, Victor V Bartsevich, Caitlin A Turner, Janel Lape, Samantha Kirkland, Clayton W Beard, Jeff Smith, Matthew L Hirsch, Michael G Nicholson, Derek Jantz, Bruce McCreedy
Adoptive cellular therapy using chimeric antigen receptor (CAR) T cell therapies have produced significant objective responses in patients with CD19(+) hematological malignancies, including durable complete responses. Although the majority of clinical trials to date have used autologous patient cells as the starting material to generate CAR T cells, this strategy poses significant manufacturing challenges and, for some patients, may not be feasible because of their advanced disease state or difficulty with manufacturing suitable numbers of CAR T cells...
February 22, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28228131/whole-genome-sequencing-of-one-complex-pedigree-illustrates-challenges-with-genomic-medicine
#20
Han Fang, Yiyang Wu, Hui Yang, Margaret Yoon, Laura T Jiménez-Barrón, David Mittelman, Reid Robison, Kai Wang, Gholson J Lyon
BACKGROUND: Human Phenotype Ontology (HPO) has risen as a useful tool for precision medicine by providing a standardized vocabulary of phenotypic abnormalities to describe presentations of human pathologies; however, there have been relatively few reports combining whole genome sequencing (WGS) and HPO, especially in the context of structural variants. METHODS: We illustrate an integrative analysis of WGS and HPO using an extended pedigree, which involves Prader-Willi Syndrome (PWS), hereditary hemochromatosis (HH), and dysautonomia-like symptoms...
February 23, 2017: BMC Medical Genomics
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