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https://www.readbyqxmd.com/read/29029236/first-in-human-experience-with-complete-integration-of-neuromodulation-device-within-a-customized-cranial-implant
#1
Chad R Gordon, Gabriel F Santiago, Judy Huang, Gregory K Bergey, Shuya Liu, Mehran Armand, Henry Brem, William S Anderson
BACKGROUND: Neuromodulation devices have the potential to transform modern day treatments for patients with medicine-resistant neurological disease. For instance, the NeuroPace System (NeuroPace Inc, Mountain View, California) is a Food and Drug Administration (FDA)-approved device developed for closed-loop direct brain neurostimulation in the setting of drug-resistant focal epilepsy. However, current methods require placement either above or below the skull in nonanatomic locations. This type of positioning has several drawbacks including visible deformities and scalp pressure from underneath leading to eventual wound healing difficulties, micromotion of hardware with infection, and extrusion leading to premature explantation...
October 6, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29023813/dual-catenin-loss-in-murine-liver-causes-tight-junctional-deregulation-and-progressive-intrahepatic-cholestasis
#2
Tirthadipa Pradhan-Sundd, Lili Zhou, Ravi Vats, An Jiang, Laura Molina, Sucha Singh, Minakshi Poddar, Jacquelyn M Russell, Donna B Stolz, Michael Oertel, Udayan Apte, Simon Watkins, Sarangarajan Ranganathan, Kari N Nejak-Bowen, Prithu Sundd, Satdarshan Pal Monga
β-Catenin, the downstream effector of the Wnt signaling, plays important roles in hepatic development, regeneration and tumorigenesis. However, its role at hepatocyte adherens junctions (AJ) is relatively poorly understood, chiefly due to spontaneous compensation by γ-catenin. Here, we simultaneously ablate β- and γ-catenin expression in mouse liver by interbreeding β-catenin-γ-catenin double-floxed mice and albumin-cre transgenic mice. Double knockout mice (DKO) show failure to thrive, impaired hepatocyte differentiation, cholemia, ductular reaction, progressive cholestasis, inflammation, fibrosis and tumorigenesis, which was associated with deregulation of tight junctions (TJ) and bile acid transporters, leading to early morbidity and mortality, a phenotype reminiscent of Progressive Familial Intrahepatic Cholestasis (PFIC)...
October 10, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29023446/towards-elimination-of-visceral-leishmaniasis-in-the-indian-subcontinent-translating-research-to-practice-to-public-health
#3
REVIEW
Siddhivinayak Hirve, Axel Kroeger, Greg Matlashewski, Dinesh Mondal, Megha Raj Banjara, Pradeep Das, Ahmed Be-Nazir, Byron Arana, Piero Olliaro
BACKGROUND: The decade following the Regional Strategic Framework for Visceral Leishmaniasis (VL) elimination in 2005 has shown compelling progress in the reduction of VL burden in the Indian subcontinent. The Special Programme for Research and Training in Tropical Diseases (TDR), hosted by the World Health Organization (WHO) and other stakeholders, has coordinated and financed research for the development of new innovative tools and strategies to support the regional VL elimination initiative...
October 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29017856/planning-an-innovation-marathon-at-an-infectious-disease-conference-with-results-from-the-imed-2016-hackathon
#4
John W Ramatowski, Christopher Xiang Lee, Aikaterini Mantzavino, João Ribas, Winter Guerra, Nicholas D Preston, Eva Schernhammer, Lawrence C Madoff, Britta Lassmann
A hackathon is best described as an "innovation marathon." Derived from the words "hacking" and "marathon," it brings together multi-disciplinary teams to collaborate intensely over a short period of time to define a problem, devise a solution, and design a working prototype. International scientific meetings are conducive to successful hackathons, providing an audience of expert professionals who describe challenges and ensure the proposed solutions address end-user needs. Collaborations with local organizations and academic centers are crucial to attracting complementary specialties such as IT advisors, engineers, and entrepreneurs to develop sustainable projects...
October 7, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28955443/solar-thermotherapy-reduces-the-titer-of-candidatus-liberibacter-asiaticus-and-enhances-canopy-growth-by-altering-gene-expression-profiles-in-hlb-affected-citrus-plants
#5
Melissa M Doud, Yungsheng Wang, Michelle T Hoffman, Christina L Latza, Weiqi Luo, Cheryl M Armstrong, Tim R Gottwald, Liangying Dai, Feng Luo, Yongping Duan
Huanglongbing (HLB), a systemic and destructive disease of citrus, is associated with 'Candidatus Liberibacter asiaticus' (Las) in the United States. Our earlier work has shown that Las bacteria were significantly reduced or eliminated when potted HLB-affected citrus were continuously exposed to high temperatures of 40 to 42 °C for a minimum of 48 h. To determine the feasibility and effectiveness of solar thermotherapy in the field, portable plastic enclosures were placed over commercial and residential citrus, exposing trees to high temperatures through solarization...
2017: Horticulture Research
https://www.readbyqxmd.com/read/28950893/neglected-tropical-diseases-exploring-long-term-practical-approaches-to-achieve-sustainable-disease-elimination-and-beyond
#6
Giuseppina Ortu, Oliver Williams
BACKGROUND: Remarkable progress has been made in the fight against neglected tropical diseases, but new challenges have emerged. Innovative diagnostics, better drugs and new insecticides are often identified as the priority; however, access to these new tools may not be sufficient to achieve and sustain disease elimination, if certain challenges and priorities are not considered. MAIN BODY: The authors summarise key operational challenges, and based on these, identify two major priorities: strengthening the capacity of the primary health care health system in correctly diagnosing and managing neglected tropical diseases; and establishing an effective disease surveillance process...
September 27, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28950834/challenges-of-implementing-the-integrated-disease-surveillance-and-response-strategy-in-zambia-a-health-worker-perspective
#7
Chomba Brian Mandyata, Linda Kampata Olowski, Wilbroad Mutale
BACKGROUND: Despite advances in medical technology and public health practice at the global level over the past millennia, infectious diseases are still the leading causes of death in most resource limited countries. Stronger infectious disease surveillance and response systems in developed countries facilitated the near elimination of infectious disease related deaths in those countries. Today, low-income countries are following this path by strengthening disease surveillance and response strategies that would help reverse the trend in infectious disease associated morbidity and mortality cases...
September 26, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28950819/developmental-pharmacokinetics-in-neonates-maturational-changes-and-beyond
#8
Karel Allegaert, Paola Mian, John van den Anker
BACKGROUND: Effective and safe pharmacotherapy in an individual neonate necessitates understanding the pharmacokinetic (PK) and pharmacodynamic (PD) properties of a specific drug together with the characteristics of this neonate. METHODS: Developmental PK hereby provides estimates of the concentration-time profile. Multiple maturational, disease and treatment related differences can result in differences in PK and probably also in PD in neonates compared to other populations...
September 26, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28944276/verification-of-neonatal-tetanus-surveillance-systems-in-katsina-state-nigeria
#9
Shafique Sani Nass, Hadi Danawi, Loretta Cain, Monoj Sharma
BACKGROUND: The incidence and mortality rates of neonatal tetanus (NNT) remain underreported in Nigeria. The goal of the study was to compare the NNT prevalence and the mortality rates from the existing surveillance system and active surveillance of health facility records in 7 selected health facilities from 2010 to 2014 in Katsina State, Nigeria. METHODS: The study is a retrospective record review using extracted data from NNT records and analyzed using descriptive statistics...
January 2017: Health Services Research and Managerial Epidemiology
https://www.readbyqxmd.com/read/28939351/standardization-of-nodal-radiation-therapy-through-changes-to-a-breast-cancer-clinical-pathway-throughout-a-large-integrated-cancer-center-network
#10
Brian J Gebhardt, Joel Thomas, Zachary D Horne, Colin E Champ, Gretchen M Ahrendt, Emilia Diego, Dwight E Heron, Sushil Beriwal
BACKGROUND: Studies demonstrate safety of omitting axillary nodal dissection for early-stage breast cancer with positive sentinel lymph node (+SLN) biopsy, although trial designs differed in radiation therapy (RT) fields. Regional nodal irradiation was separately shown to improve outcomes in high-risk patients. This led to lack of consensus in RT volumes. Clinical pathways (CPs) standardize care where practice varies unnecessarily. We evaluated the impact of changes to a CP guiding postoperative RT in women with +SLNs on practice patterns throughout a network...
July 20, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28937603/proteome-stability-as-a-key-factor-of-genome-integrity
#11
REVIEW
Sentiljana Gumeni, Zoi Evangelakou, Vassilis G Gorgoulis, Ioannis P Trougakos
DNA damage is constantly produced by both endogenous and exogenous factors; DNA lesions then trigger the so-called DNA damaged response (DDR). This is a highly synchronized pathway that involves recognition, signaling and repair of the damage. Failure to eliminate DNA lesions is associated with genome instability, a driving force in tumorigenesis. Proteins carry out the vast majority of cellular functions and thus proteome quality control (PQC) is critical for the maintenance of cellular functionality. PQC is assured by the proteostasis network (PN), which under conditions of proteome instability address the triage decision of protein fold, hold, or degrade...
September 22, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28934198/-koko-et-les-lunettes-magiques-an-educational-entertainment-tool-to-prevent-parasitic-worms-and-diarrheal-diseases-in-c%C3%A3-te-d-ivoire
#12
Clémence Essé, Véronique A Koffi, Abel Kouamé, Kouassi Dongo, Richard B Yapi, Honorine M Moro, Christiane A Kouakou, Marta S Palmeirim, Bassirou Bonfoh, Eliézer K N'Goran, Jürg Utzinger, Giovanna Raso
BACKGROUND: Integrated control programs, emphasizing preventive chemotherapy along with health education, can reduce the incidence of soil-transmitted helminthiasis and schistosomiasis. The aim of this study was to develop an educational animated cartoon to improve school children's awareness regarding soil-transmitted helminthiasis, diarrheal diseases, and related hygiene practices in Côte d'Ivoire. The key messages included in the cartoon were identified through prior formative research to specifically address local knowledge gaps...
September 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28928423/use-of-an-individual-based-model-to-control-transmission-pathways-of-mycobacterium-avium-subsp-paratuberculosis-infection-in-cattle-herds
#13
M A Al-Mamun, R L Smith, Y H Schukken, Y T Gröhn
Johne's disease (JD) is a chronic enteric disease in cattle caused by Mycobacterium avian subsp. paratuberculosis (MAP). Eradicating JD is a difficult task due to the long incubation period of MAP, inefficient diagnostic tests, and delayed clinical signs. Effective control strategies can help farmers to reduce prevalence, but those most acceptable to farmers combine specific information about lactation performance and testing results, which existing models do not provide. This paper presents an individual-based model of MAP infection dynamics and assesses the relative performance of the applied alternative control strategies...
September 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28922418/detecting-and-confirming-residual-hotspots-of-lymphatic-filariasis-transmission-in-american-samoa-8-years-after-stopping-mass-drug-administration
#14
Colleen L Lau, Sarah Sheridan, Stephanie Ryan, Maureen Roineau, Athena Andreosso, Saipale Fuimaono, Joseph Tufa, Patricia M Graves
The Global Programme to Eliminate Lymphatic Filariasis (LF) aims to eliminate the disease as a public health problem by 2020 by conducting mass drug administration (MDA) and controlling morbidity. Once elimination targets have been reached, surveillance is critical for ensuring that programmatic gains are sustained, and challenges include timely identification of residual areas of transmission. WHO guidelines encourage cost-efficient surveillance, such as integration with other population-based surveys. In American Samoa, where LF is caused by Wuchereria bancrofti, and Aedes polynesiensis is the main vector, the LF elimination program has made significant progress...
September 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28921465/emerging-roles-for-epigenetic-programming-in-the-control-of-inflammatory-signaling-integration-in-heath-and-disease
#15
Yiqun Hu, Feng Yan, Le Ying, Dakang Xu
Macrophages and dendritic cells initiate the innate immune response to infection and injury and contribute to inflammatory signaling to maintain the homeostasis of various tissues, which includes resident macrophages for the elimination of invading microorganisms and tissue damage. Inappropriate inflammatory signaling can lead to persistent inflammation and further develop into autoimmune and inflammation-associated diseases. Inflammatory signaling pathways have been well characterized, but how these signaling pathways are converted into sustained and diverse patterns of expression of cytokines, chemokines, and other genes in response to environmental challenges is unclear...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28899362/nationwide-cross-sectional-survey-of-schistosomiasis-and-soil-transmitted-helminthiasis-in-sudan-study-protocol
#16
Seungman Cha, Sung-Tae Hong, Young-Ha Lee, Keon Hoon Lee, Dae Seong Cho, Jinmoo Lee, Jong-Yil Chai, Mousab Siddig Elhag, Soheir Gabralla Ahmad Khaled, Mustafa Khidir Mustafa Elnimeiri, Nahid Abdelgadeir Ali Siddig, Hana Abdelrazig, Sarah Awadelkareem, Azza Tag Eldin Elshafie, Hassan Ahmed Hassan Ahmed Ismail, Mutamad Amin
BACKGROUND: Schistosomiasis and soil-transmitted helminthiasis (STHs) are target neglected tropical diseases (NTDs) of preventive chemotherapy, but the control and elimination of these diseases have been impeded due to resource constraints. Few reports have described study protocol to draw on when conducting a nationwide survey. We present a detailed methodological description of the integrated mapping of schistosomiasis and STHs on the basis of our experiences, hoping that this protocol can be applied to future surveys in similar settings...
September 12, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28892479/towards-chagas-disease-elimination-neonatal-screening-for-congenital-transmission-in-rural-communities
#17
Pamela Marie Pennington, José Guillermo Juárez, Margarita Rivera Arrivillaga, Sandra María De Urioste-Stone, Katherine Doktor, Joe P Bryan, Clara Yaseli Escobar, Celia Cordón-Rosales
Chagas disease is a neglected tropical disease that continues to affect populations living in extreme poverty in Latin America. After successful vector control programs, congenital transmission remains as a challenge to disease elimination. We used the PRECEDE-PROCEED planning model to develop strategies for neonatal screening of congenital Chagas disease in rural communities of Guatemala. These communities have persistent high triatomine infestations and low access to healthcare. We used mixed methods with multiple stakeholders to identify and address maternal-infant health behaviors through semi-structured interviews, participatory group meetings, archival reviews and a cross-sectional survey in high risk communities...
September 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28886171/positive-predictive-value-and-effectiveness-of-measles-case-based-surveillance-in-uganda-2012-2015
#18
Fred Nsubuga, Immaculate Ampaire, Simon Kasasa, Henry Luzze, Annet Kisakye
INTRODUCTION: Disease surveillance is a critical component in the control and elimination of vaccine preventable diseases. The Uganda National Expanded Program on Immunization strives to have a sensitive surveillance system within the Integrated Disease Surveillance and Response (IDSR) framework. We analyzed measles surveillance data to determine the effectiveness of the measles case-based surveillance system and estimate its positive predictive value in order to inform policy and practice...
2017: PloS One
https://www.readbyqxmd.com/read/28884235/a-cross-sectional-survey-comparing-a-free-treatment-program-for-advanced-schistosomiasis-japonica-to-a-general-assistance-program
#19
Langui Song, Xiaoying Wu, Beibei Zhang, Jiahua Liu, An Ning, Zhongdao Wu
The prevalence and intensity of schistosomiasis has dropped dramatically in China due to an effective integrated control program. However, advanced schistosomiasis is becoming a key challenge on the road to elimination. The aims of this study were to compare the disease condition between advanced cases under the general assistance program (GAP) and free treatment program (FTP) and to determine whether the FTP should be popularized to provide an objective reference for policymakers in China's advanced schistosomiasis control program...
September 7, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28883528/knowledge-attitude-and-practice-about-malaria-socio-demographic-implications-for-malaria-control-in-rural-ghana
#20
Abraham Assan, Amirhossein Takian, Ahmad Ali Hanafi-Bojd, Abbas Rahimiforoushani, Shahrzad Nematolahi
Despite continuing international attention to malaria prevention, the disease remains a global public health problem. We investigated socio-demographic factors influencing knowledge, attitudes, and practices about malaria in rural Ghana. Our survey looked at 354 households. Mean knowledge score was higher among individuals with a history of volunteers having visited their households to educate them about malaria; families with 4-6 members; and males. Households with at least one under-five-aged child also had significantly higher knowledge scores...
September 7, 2017: Journal of Public Health Policy
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