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Integrated surveillance response

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https://www.readbyqxmd.com/read/29142064/the-resurrection-of-the-piddosome-emerging-roles-in-the-dna-damage-response-and-centrosome-surveillance
#1
REVIEW
Valentina Sladky, Fabian Schuler, Luca L Fava, Andreas Villunger
The PIDDosome is often used as the alias for a multi-protein complex that includes the p53-induced death domain protein 1 (PIDD1), the bipartite linker protein CRADD (also known as RAIDD) and the pro-form of an endopeptidase belonging to the caspase family, i.e. caspase-2. Yet, PIDD1 variants can also interact with a number of other proteins that include RIPK1 (also known as RIP1) and IKBKG (also known as NEMO), PCNA and RFC5, as well as nucleolar components such as NPM1 or NCL. This promiscuity in protein binding is facilitated mainly by autoprocessing of the full-length protein into various fragments that contain different structural domains...
November 15, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/29138016/the-challenges-of-detecting-and-responding-to-a-lassa-fever-outbreak-in-an-ebola-affected-setting
#2
E L Hamblion, P Raftery, A Wendland, E Dweh, G S Williams, R N C George, L Soro, V Katawera, P Clement, A N Gasasira, E Musa, T K Nagbe
OBJECTIVES: Lassa fever(LF), a priority emerging pathogen likely to cause major epidemics, is endemic in much of West Africa and difficult to distinguish from other viral haemorrhagic fevers including Ebola virus disease(EVD). Definitive diagnosis requires laboratory confirmation not widely available in affected settings. We report the public health action to contain a LF outbreak and challenges encountered in an EVD-affected setting. METHODS: In February 2016 a rapid response team was deployed in Liberia in response to a cluster of LF cases...
November 11, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29132370/expanding-malaria-diagnosis-and-treatment-in-lao-pdr-lessons-learned-from-a-public-private-mix-initiative
#3
Nouannipha Simmalavong, Sengkham Phommixay, Phoudaliphone Kongmanivong, Odai Sichanthongthip, Bouasy Hongvangthong, Deyer Gopinath, David M Sintasath
BACKGROUND: As in other countries of the Greater Mekong Sub-region (GMS), the private health sector constitutes a significant avenue where malaria services are provided and presents a unique opportunity for public-private collaboration. In September 2008, a public-private mix (PPM) strategy was launched initially in four northern and southern provinces in Lao PDR to increase access to rapid diagnostic tests (RDTs) and artemisinin-based combination therapy (ACT), improve quality of care, and collect routine malaria data from the private sector...
November 13, 2017: Malaria Journal
https://www.readbyqxmd.com/read/29114488/seroprevalence-of-human-cystic-echinococcosis-from-north-india-2004-2015
#4
Kamran Zaman, Abhishek Mewara, Sunil Kumar, Kapil Goyal, Sumeeta Khurana, Praveen Tripathi, Rakesh Sehgal
Context: Cystic echinococcosis (CE) caused by Echinococcus granulosus is a disease of a significant burden in India. The World Health Organization recommends the use of hospital data for population surveillance to measure the prevalence of CE. Aim: The aim of this study was to estimate the seroprevalence of CE and to compare with previous prevalence rates to estimate the changing pattern in seroprevalence of CE. Materials and Methods: A retrospective analysis of laboratory data of 3929 clinically and/or radiologically suspected cases of CE was carried out for 12 years from 2004 to 2015 and compared to the previous data from 1984 to 2003...
July 2017: Tropical Parasitology
https://www.readbyqxmd.com/read/29098145/emerging-and-reemerging-diseases-in-the-world-health-organization-who-eastern-mediterranean-region-progress-challenges-and-who-initiatives
#5
REVIEW
Evans Buliva, Mohamed Elhakim, Nhu Nguyen Tran Minh, Amgad Elkholy, Peter Mala, Abdinasir Abubakar, Sk Md Mamunur Rahman Malik
The Eastern Mediterranean Region (EMR) of the World Health Organization (WHO) continues to be a hotspot for emerging and reemerging infectious diseases and the need to prevent, detect, and respond to any infectious diseases that pose a threat to global health security remains a priority. Many risk factors contribute in the emergence and rapid spread of epidemic diseases in the Region including acute and protracted humanitarian emergencies, resulting in fragile health systems, increased population mobility, rapid urbanization, climate change, weak surveillance and limited laboratory diagnostic capacity, and increased human-animal interaction...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/29082006/zika-pandemic-online-trends-incidence-and-health-risk-communication-a-time-trend-study
#6
Gbenga Adebayo, Yehuda Neumark, Anat Gesser-Edelsburg, Wiessam Abu Ahmad, Hagai Levine
OBJECTIVES: We aimed to describe the online search trends of Zika and examine their association with Zika incidence, assess the content of Zika-related press releases issued by leading health authorities and examine the association between online trends and press release timing. DESIGN: Using Google Trends, the 1 May 2015 to 30 May 2016 online trends of Zika and associated search terms were studied globally and in the five countries with the highest numbers of suspected cases...
2017: BMJ Global Health
https://www.readbyqxmd.com/read/29075457/territory-surveillance-and-prey-management-wolves-keep-track-of-space-and-time
#7
Ulrike E Schlägel, Evelyn H Merrill, Mark A Lewis
Identifying behavioral mechanisms that underlie observed movement patterns is difficult when animals employ sophisticated cognitive-based strategies. Such strategies may arise when timing of return visits is important, for instance to allow for resource renewal or territorial patrolling. We fitted spatially explicit random-walk models to GPS movement data of six wolves (Canis lupus; Linnaeus, 1758) from Alberta, Canada to investigate the importance of the following: (1) territorial surveillance likely related to renewal of scent marks along territorial edges, to reduce intraspecific risk among packs, and (2) delay in return to recently hunted areas, which may be related to anti-predator responses of prey under varying prey densities...
October 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/29069457/nol12-is-a-multifunctional-rna-binding-protein-at-the-nexus-of-rna-and-dna-metabolism
#8
Daniel D Scott, Christian Trahan, Pierre J Zindy, Lisbeth C Aguilar, Marc Y Delubac, Eric L Van Nostrand, Srivathsan Adivarahan, Karen E Wei, Gene W Yeo, Daniel Zenklusen, Marlene Oeffinger
To counteract the breakdown of genome integrity, eukaryotic cells have developed a network of surveillance pathways to prevent and resolve DNA damage. Recent data has recognized the importance of RNA binding proteins (RBPs) in DNA damage repair (DDR) pathways. Here, we describe Nol12 as a multifunctional RBP with roles in RNA metabolism and genome maintenance. Nol12 is found in different subcellular compartments-nucleoli, where it associates with ribosomal RNA and is required for efficient separation of large and small subunit precursors at site 2; the nucleoplasm, where it co-localizes with the RNA/DNA helicase Dhx9 and paraspeckles; as well as GW/P-bodies in the cytoplasm...
October 23, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29069191/three-decades-of-hospital-epidemiology-and-the-challenge-of-integrating-health-surveillance-reflections-from-a-case-study
#9
Claudia Caminha Escosteguy, Alessandra Gonçalves Lisbôa Pereira, Roberto de Andrade Medronho
This study proposes a reflection on the uses and future prospects of hospital-based health surveillance based on the account of a pioneering experience in hospital epidemiology, the epidemiology service at the Hospital Federal dos Servidores do Estado - HFSE, which served as the basis for the creation of epidemiologic surveillance units in municipal and state hospitals in Rio de Janeiro, Brazil. The epidemiology service has combined epidemiological surveillance, continuing education, in-service training, research, and health service evaluation since 1986...
October 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/29069171/brazilian-health-surveillance-reflections-and-contribution-to-the-debate-of-the-first-national-conference-on-health-surveillance
#10
Guilherme Franco, Juliana Wotzasek Rulli Villardi, Jorge Mesquita Huet Machado, Maria do Socorro de Souza, Ivo Ferreira Brito, Juliana Acosta Santorum, Carlos Octávio Ocké-Reis, André Luiz Dutra Fenner
This is a research on the challenges of Health Surveillance, considering its theories and practices. We performed a comprehensive review of international and national literature and institutional documents. Some of the authors also participated in the formulation of the guideline document prepared by the Formulation and Reporting Committee of the First National Conference on Health Surveillance. The complex Brazilian reality imposes that Health Surveillance be guided in a universal, integrated, participatory and territorial manner, where society and SUS workers play a leading role...
October 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/29051489/genomic-landscape-associated-with-potential-response-to-anti-ctla-4-treatment-in-cancers
#11
Chan-Young Ock, Jun-Eul Hwang, Bhumsuk Keam, Sang-Bae Kim, Jae-Jun Shim, Hee-Jin Jang, Sarang Park, Bo Hwa Sohn, Minse Cha, Jaffer A Ajani, Scott Kopetz, Keun-Wook Lee, Tae Min Kim, Dae Seog Heo, Ju-Seog Lee
Immunotherapy has emerged as a promising anti-cancer treatment, however, little is known about the genetic characteristics that dictate response to immunotherapy. We develop a transcriptional predictor of immunotherapy response and assess its prediction in genomic data from ~10,000 human tissues across 30 different cancer types to estimate the potential response to immunotherapy. The integrative analysis reveals two distinct tumor types: the mutator type is positively associated with potential response to immunotherapy, whereas the chromosome-instable type is negatively associated with it...
October 19, 2017: Nature Communications
https://www.readbyqxmd.com/read/29026651/snvphyl-a-single-nucleotide-variant-phylogenomics-pipeline-for-microbial-genomic-epidemiology
#12
Aaron Petkau, Philip Mabon, Cameron Sieffert, Natalie C Knox, Jennifer Cabral, Mariam Iskander, Mark Iskander, Kelly Weedmark, Rahat Zaheer, Lee S Katz, Celine Nadon, Aleisha Reimer, Eduardo Taboada, Robert G Beiko, William Hsiao, Fiona Brinkman, Morag Graham, Gary Van Domselaar
The recent widespread application of whole-genome sequencing (WGS) for microbial disease investigations has spurred the development of new bioinformatics tools, including a notable proliferation of phylogenomics pipelines designed for infectious disease surveillance and outbreak investigation. Transitioning the use of WGS data out of the research laboratory and into the front lines of surveillance and outbreak response requires user-friendly, reproducible and scalable pipelines that have been well validated...
June 30, 2017: Microbial Genomics
https://www.readbyqxmd.com/read/29023984/partial-to-complete-abrogation-of-the-sub-epithelial-macrophage-barrier-against-the-gut-microbiota-in-patients-with-ulcerative-colitis-and-crohn-s-colitis
#13
Carlos A Rubio, Cord Langner, Peter T Schmidt
AIMS: The integrity of the subepithelial band of indigenous macrophages in the lamina-propria (SLP-MΦ) is crucial in deterring the commensal gut-microbiota from host-assailment. The breakdown of the SLP-MΦ barrier results in microbiota inflow and improper immune responses; this might lead to IBD. During inflammation, the SLP-MΦ-barrier is reinforced by inflammation-elicited MΦ (IEMΦ, derived from blood-circulating monocytes). The aim was to explore the characteristics of the SLP-MΦ band in a cohort of biopsies without inflammation, in patients with ulcerative colitis-in remission (UCre), and in patients with right-sided Crohn's colitis (RCC)...
October 11, 2017: Histopathology
https://www.readbyqxmd.com/read/28991904/epidemiological-consequences-of-immune-sensitisation-by-pre-exposure-to-vector-saliva
#14
Tsukushi Kamiya, Megan A Greischar, Nicole Mideo
Blood-feeding arthropods-like mosquitoes, sand flies, and ticks-transmit many diseases that impose serious public health and economic burdens. When a blood-feeding arthropod bites a mammal, it injects saliva containing immunogenic compounds that facilitate feeding. Evidence from Leishmania, Plasmodium and arboviral infections suggests that the immune responses elicited by pre-exposure to arthropod saliva can alter disease progression if the host later becomes infected. Such pre-sensitisation of host immunity has been reported to both exacerbate and limit infection symptoms, depending on the system in question, with potential implications for recovery...
October 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28983394/status-of-surveillance-and-routine-immunization-performances-in-amhara-region-ethiopia-findings-from-in-depth-peer-review
#15
Gebre Asmamaw Lakew, Eshetu Wassie, Ayesheshem Ademe, Ayalneh Fenta, Solomon Wube, Mihret Werede, Achenef Kidane, Leulseged Mekonnen, Teklehaimanot Gebre Hiwot, Kathleen Gallagher
INTRODUCTION: Trend analyses of non-polio AFP and stool adequacy rates in Amhara Region showed optimal performance over the years. However, sub regional gaps continue to persist in certain zones where the reasons for low performance were not well documented. The objective of this study was to assess the performance of the disease surveillance and immunization system in Amhara Region, Ethiopia with emphasis on low performing woredas and zones. METHODS: A descriptive cross-sectional study was conducted from July 2-10, 2015 to assess the structure, core and support surveillance functions in five zones and two town administrations that were purposively sampled based on differing performances, geographic location, and history of vaccine preventable disease outbreaks among others...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28950834/challenges-of-implementing-the-integrated-disease-surveillance-and-response-strategy-in-zambia-a-health-worker-perspective
#16
Chomba Brian Mandyata, Linda Kampata Olowski, Wilbroad Mutale
BACKGROUND: Despite advances in medical technology and public health practice at the global level over the past millennia, infectious diseases are still the leading causes of death in most resource limited countries. Stronger infectious disease surveillance and response systems in developed countries facilitated the near elimination of infectious disease related deaths in those countries. Today, low-income countries are following this path by strengthening disease surveillance and response strategies that would help reverse the trend in infectious disease associated morbidity and mortality cases...
September 26, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28948003/the-hedgehog-gli-pathway-in-embryonic-development-and-cancer-implications-for-pulmonary-oncology-therapy
#17
REVIEW
Leonel Armas-López, Joaquín Zúñiga, Oscar Arrieta, Federico Ávila-Moreno
Transcriptional regulation and epigenetic mechanisms closely control gene expression through diverse physiological and pathophysiological processes. These include the development of germ layers and post-natal epithelial cell-tissue differentiation, as well as, involved with the induction, promotion and/or progression of human malignancies. Diverse studies have shed light on the molecular similarities and differences involved in the stages of embryological epithelial development and dedifferentiation processes in malignant tumors of epithelial origin, of which many focus on lung carcinomas...
September 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28944731/the-fda-unapproved-drugs-initiative-an-observational-study-of-the-consequences-for-drug-prices-and-shortages-in-the-united-states
#18
Ravi Gupta, Sanket S Dhruva, Erin R Fox, Joseph S Ross
BACKGROUND: Hundreds of drug products are currently marketed in the United States without approval from the FDA. The 2006 Unapproved Drugs Initiative (UDI) requires manufacturers to remove these drug products from the market or obtain FDA approval by demonstrating evidence of safety and efficacy. Once the FDA acts against an unapproved drug, fewer manufacturers remain in the market, potentially enabling drug price increases and greater susceptibility to drug shortages. There is a need for systematic study of the UDI's effect on prices and shortages of all targeted drugs...
October 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28944276/verification-of-neonatal-tetanus-surveillance-systems-in-katsina-state-nigeria
#19
Shafique Sani Nass, Hadi Danawi, Loretta Cain, Monoj Sharma
BACKGROUND: The incidence and mortality rates of neonatal tetanus (NNT) remain underreported in Nigeria. The goal of the study was to compare the NNT prevalence and the mortality rates from the existing surveillance system and active surveillance of health facility records in 7 selected health facilities from 2010 to 2014 in Katsina State, Nigeria. METHODS: The study is a retrospective record review using extracted data from NNT records and analyzed using descriptive statistics...
January 2017: Health Services Research and Managerial Epidemiology
https://www.readbyqxmd.com/read/28935999/integrating-a-biorepository-into-the-national-amyotrophic-lateral-sclerosis-registry
#20
D Kevin Horton, Wendy Kaye, Laurie Wagner
As part of our continuing effort to highlight innovative approaches to improving the health and environment of communities, the Journal is pleased to publish a bimonthly column from the Agency for Toxic Substances and Disease Registry (ATSDR). ATSDR is a federal public health agency of the U.S. Department of Health and Human Services (HHS) and shares a common office of the Director with the National Center for Environmental Health (NCEH) at the Centers for Disease Control and Prevention (CDC). ATSDR serves the public by using the best science, taking responsive public health actions, and providing trusted health information to prevent harmful exposures and diseases related to toxic substances...
November 2016: Journal of Environmental Health
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