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Integrated surveillance response

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https://www.readbyqxmd.com/read/28090466/microbiome-linked-crosstalk-in-the-gastrointestinal-exposome-towards-host-health-and-disease
#1
REVIEW
Yuseok Moon
The gastrointestinal exposome represents the integration of all xenobiotic components and host-derived endogenous components affecting the host health, disease progression and ultimately clinical outcomes during the lifespan. The human gut microbiome as a dynamic exposome of commensalism continuously interacts with other exogenous exposome as well as host sentineling components including the immune and neuroendocrine circuit. The composition and diversity of the microbiome are established on the basis of the luminal environment (physical, chemical and biological exposome) and host surveillance at each part of the gastrointestinal lining...
December 2016: Pediatric Gastroenterology, Hepatology & Nutrition
https://www.readbyqxmd.com/read/28078449/social-media-responses-to-heat-waves
#2
Jihoon Jung, Christopher K Uejio
Social network services (SNSs) may benefit public health by augmenting surveillance and distributing information to the public. In this study, we collected Twitter data focusing on six different heat-related themes (air conditioning, cooling center, dehydration, electrical outage, energy assistance, and heat) for 182 days from May 7 to November 3, 2014. First, exploratory linear regression associated outdoor heat exposure to the theme-specific tweet counts for five study cities (Los Angeles, New York, Chicago, Houston, and Atlanta)...
January 11, 2017: International Journal of Biometeorology
https://www.readbyqxmd.com/read/28077875/structural-basis-of-co-translational-quality-control-by-arfa-and-rf2-bound-to-ribosome
#3
Fuxing Zeng, Yanbo Chen, Jonathan Remis, Mrinal Shekhar, James C Phillips, Emad Tajkhorshid, Hong Jin
Quality control mechanisms intervene appropriately when defective translation events occur, in order to preserve the integrity of protein synthesis. Rescue of ribosomes translating on messenger RNAs that lack stop codons is one of the co-translational quality control pathways. In many bacteria, ArfA recognizes stalled ribosomes and recruits the release factor RF2, which catalyses the termination of protein synthesis. Although an induced-fit mechanism of nonstop mRNA surveillance mediated by ArfA and RF2 has been reported, the molecular interaction between ArfA and RF2 in the ribosome that is responsible for the mechanism is unknown...
January 11, 2017: Nature
https://www.readbyqxmd.com/read/28073532/toxigenic-algae-and-associated-phycotoxins-in-two-coastal-embayments-in-the-ebro-delta-nw-mediterranean
#4
Julia A Busch, Karl B Andree, Jorge Diogène, Margarita Fernández-Tejedor, Kerstin Toebe, Uwe John, Bernd Krock, Urban Tillmann, Allan D Cembella
Harmful Algal Bloom (HAB) surveillance is complicated by high diversity of species and associated phycotoxins. Such species-level information on taxonomic affiliations and on cell abundance and toxin content is, however, crucial for effective monitoring, especially of aquaculture and fisheries areas. The aim addressed in this study was to determine putative HAB taxa and related phycotoxins in plankton from aquaculture sites in the Ebro Delta, NW Mediterranean. The comparative geographical distribution of potentially harmful plankton taxa was established by weekly field sampling throughout the water column during late spring-early summer over two years at key stations in Alfacs and Fangar embayments within the Ebro Delta...
May 2016: Harmful Algae
https://www.readbyqxmd.com/read/28073361/sustainability-of-health-information-systems-a-three-country-qualitative-study-in-southern-africa
#5
Corrina Moucheraud, Amee Schwitters, Chantelle Boudreaux, Denise Giles, Peter H Kilmarx, Ntolo Ntolo, Zwashe Bangani, Michael E St Louis, Thomas J Bossert
BACKGROUND: Health information systems are central to strong health systems. They assist with patient and program management, quality improvement, disease surveillance, and strategic use of information. Many donors have worked to improve health information systems, particularly by supporting the introduction of electronic health information systems (EHIS), which are considered more responsive and more efficient than older, paper-based systems. As many donor-driven programs are increasing their focus on country ownership, sustainability of these investments is a key concern...
January 10, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28036033/mec1-atr-the-program-manager-of-nucleic-acids-inc
#6
REVIEW
Wenyi Feng
Eukaryotic cells are equipped with surveillance mechanisms called checkpoints to ensure proper execution of cell cycle events. Among these are the checkpoints that detect DNA damage or replication perturbations and coordinate cellular activities to maintain genome stability. At the forefront of damage sensing is an evolutionarily conserved molecule, known respectively in budding yeast and humans as Mec1 (Mitosis entry checkpoint 1) and ATR (Ataxia telangiectasia and Rad3-related protein). Through phosphorylation, Mec1/ATR activates downstream components of a signaling cascade to maintain nucleotide pool balance, protect replication fork integrity, regulate activation of origins of replication, coordinate DNA repair, and implement cell cycle delay...
December 28, 2016: Genes
https://www.readbyqxmd.com/read/27917962/human-and-animal-health-surveys-among-pastoralists
#7
E Schelling, H Greter, H Kessely, M F Abakar, B N Ngandolo, L Crump, B Bold, J Kasymbekov, Z Baljinnyam, G Fokou, J Zinsstag, B Bonfoh, J Hattendorf, M Béchir
Valid human and livestock health surveys, including longitudinal follow-up, are feasible among mobile pastoralists and provide fundamental information to agencies for interventions that are responsive to realities and effective in addressing the needs of pastoralists. However, pastoralists are often excluded from studies, surveillance systems and health programmes. The occurrence of preventable and treatable diseases such as perinatal tetanus, measles and tuberculosis are indicative of limited access to health providers and information...
November 2016: Revue Scientifique et Technique
https://www.readbyqxmd.com/read/27914063/episweep-computationally-driven-reengineering-of-therapeutic-proteins-to-reduce-immunogenicity-while-maintaining-function
#8
Yoonjoo Choi, Deeptak Verma, Karl E Griswold, Chris Bailey-Kellogg
Therapeutic proteins are yielding ever more advanced and efficacious new drugs, but the biological origins of these highly effective therapeutics render them subject to immune surveillance within the patient's body. When recognized by the immune system as a foreign agent, protein drugs elicit a coordinated response that can manifest a range of clinical complications including rapid drug clearance, loss of functionality and efficacy, delayed infusion-like allergic reactions, more serious anaphylactic shock, and even induced auto-immunity...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27908926/the-evolution-of-the-ribosomal-protein-mdm2-p53-pathway
#9
Chad Deisenroth, Derek A Franklin, Yanping Zhang
The progression of our understanding of ribosomal proteins as static building blocks of the ribosome to highly integrated sensors of p53 surveillance and function has achieved a tremendous rate of growth over the past several decades. As the workhorse of the cell, ribosomes are responsible for translating the genetic code into the functional units that drive cell growth and proliferation. The seminal identification of ribosomal protein binding to MDM2, the negative regulator of p53, has evolved into a paradigm for ribosomal protein-MDM2-p53 signaling that extends into processes as diverse as energy metabolism to proliferation...
December 1, 2016: Cold Spring Harbor Perspectives in Medicine
https://www.readbyqxmd.com/read/27906959/pcna-dependent-cleavage-and-degradation-of-sde2-regulates-response-to-replication-stress
#10
Ukhyun Jo, Winson Cai, Jingming Wang, Yoojin Kwon, Alan D D'Andrea, Hyungjin Kim
Maintaining genomic integrity during DNA replication is essential for cellular survival and for preventing tumorigenesis. Proliferating cell nuclear antigen (PCNA) functions as a processivity factor for DNA replication, and posttranslational modification of PCNA plays a key role in coordinating DNA repair against replication-blocking lesions by providing a platform to recruit factors required for DNA repair and cell cycle control. Here, we identify human SDE2 as a new genome surveillance factor regulated by PCNA interaction...
December 2016: PLoS Genetics
https://www.readbyqxmd.com/read/27866407/forecasting-and-prediction-of-scorpion-sting-cases-in-biskra-province-algeria-using-a-seasonal-autoregressive-integrated-moving-average-model
#11
Schehrazad Selmane, Mohamed L'Hadj
OBJECTIVES: The aims of this study were to highlight some epidemiological aspects of scorpion envenomations, to analyse and interpret the available data for Biskra province, Algeria, and to develop a forecasting model for scorpion sting cases in Biskra province, which records the highest number of scorpion stings in Algeria. METHODS: In addition to analysing the epidemiological profile of scorpion stings that occurred throughout the year 2013, we used the Box-Jenkins approach to fit a seasonal autoregressive integrated moving average (SARIMA) model to the monthly recorded scorpion sting cases in Biskra from 2000 to 2012...
2016: Epidemiology and Health
https://www.readbyqxmd.com/read/27830532/role-of-microglia-in-neurological-disorders-and-their-potentials-as-a-therapeutic-target
#12
REVIEW
Li Du, Ying Zhang, Yang Chen, Jie Zhu, Yi Yang, Hong-Liang Zhang
Microglia are resident macrophage-like immune cells in the central nervous system (CNS) and play a vital role in both physiological and pathological conditions, including restoring the integrity of the CNS and promoting the progression of neurodegenerative disorders. Upon stimulation, microglia typically convert from a surveillant to an activated phenotype. The major function of microglia is to maintain homeostasis and normal function of the CNS, both during development and in response to CNS injury. Microglia regulate multiple aspects of inflammation, such as repair, cytotoxicity, regeneration, and immunosuppression due to their different kind of activation states or phenotypes...
November 9, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27826113/towards-understanding-the-epidemiology-of-neisseria-meningitidis-in-the-african-meningitis-belt-a-multi-disciplinary-overview
#13
REVIEW
Lydiane Agier, Nadège Martiny, Oumy Thiongane, Judith E Mueller, Juliette Paireau, Eleanor R Watkins, Tom J Irving, Thibaut Koutangni, Hélène Broutin
OBJECTIVES: Neisseria meningitidis is the major cause of seasonal meningitis epidemics in the African meningitis belt. In the changing context of a reduction in incidence of serogroup A and an increase in incidence of serogroups W and C and of Streptococcus pneumoniae, a better understanding of the determinants driving the disease transmission dynamics remains crucial to improving bacterial meningitis control. METHODS: The literature was searched to provide a multi-disciplinary overview of the determinants of meningitis transmission dynamics in the African meningitis belt...
January 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/27806469/lessons-learnt-from-cerebrospinal-meningitis-outbreak-surveillance-data-a-case-for-public-health-action
#14
Semeeh Akinwale Omoleke, Olatunji Alabi, Yakubu Bashar Usman, Kunle Ijaya, Abubakar Abubakar Koko
BACKGROUND: Outbreak of cerebrospinal meningitis (CSM) remains a major public health concern in Nigeria, particularly in northern Nigeria. The paper evaluates the effect of mass vaccination against cerebrospinal meningitis outbreak in 2013 on the incidence rate in 2014 and 2015, and to document lessons learnt from field experiences of the meningitis epidemic surveillance in Kebbi State, North-west, Nigeria. METHODS: The authors analysed cerebrospinal meningitis surveillance data generated from the routine integrated disease surveillance and response (IDSR) programme executed by the Ministry of Health with support from the World Health Organisation (WHO)...
June 30, 2016: Global Journal of Health Science
https://www.readbyqxmd.com/read/27803977/the-china-mental-health-survey-ii-design-and-field-procedures
#15
Zhaorui Liu, Yueqin Huang, Ping Lv, Tingting Zhang, Hong Wang, Qiang Li, Jie Yan, Yaqin Yu, Changgui Kou, Xiufeng Xu, Jin Lu, Zhizhong Wang, Hongyan Qiu, Yifeng Xu, Yanling He, Tao Li, Wanjun Guo, Hongjun Tian, Guangming Xu, Xiangdong Xu, Yanjuan Ma, Linhong Wang, Limin Wang, Yongping Yan, Bo Wang, Shuiyuan Xiao, Liang Zhou, Lingjiang Li, Liwen Tan, Hongguang Chen, Chao Ma
China Mental Health Survey (CMHS), which was carried out from July 2013 to March 2015, was the first national representative community survey of mental disorders and mental health services in China using computer-assisted personal interview (CAPI). Face-to-face interviews were finished in the homes of respondents who were selected from a nationally representative multi-stage disproportionate stratified sampling procedure. Sample selection was integrated with the National Chronic Disease and Risk Factor Surveillance Survey administered by the National Centre for Chronic and Non-communicable Disease Control and Prevention in 2013, which made it possible to obtain both physical and mental health information of Chinese community population...
November 1, 2016: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/27800077/cholera-public-health-surveillance-in-the-republic-of-cameroon-opportunities-and-challenges
#16
Moise Chi Ngwa, Song Liang, Leonard Mbam Mbam, Arabi Mouhaman, Andrew Teboh, Kaousseri Brekmo, Onana Mevoula, John Glenn Morris
INTRODUCTION: In Cameroon, cholera has periodically resurfaced since it was first reported in 1971. In 2003, Cameroon adapted the Integrated Disease Surveillance and Response (IDSR) strategy to strengthen surveillance in the country. This study was an in-depth description and assessment of the structure, core and support functions, and attributes of the current cholera surveillance system in Cameroon. It also discussed its strengths and challenges with hope that lessons learned could improve the system in Cameroon and in other countries in Africa implementing the IDSR strategy...
2016: Pan African Medical Journal
https://www.readbyqxmd.com/read/27760559/impact-of-aging-on-host-immune-response-and-survival-in-melanoma-an-analysis-of-3-patient-cohorts
#17
Sarah A Weiss, Joseph Han, Farbod Darvishian, Jeremy Tchack, Sung Won Han, Karolina Malecek, Michelle Krogsgaard, Iman Osman, Judy Zhong
BACKGROUND: Age has been reported as an independent prognostic factor for melanoma-specific survival (MSS). We tested the hypothesis that age impacts the host anti-tumor immune response, accounting for age-specific survival outcomes in three unique melanoma patient cohorts. METHODS: We queried the U.S. population-based Surveillance, Epidemiology, and End Results Program (SEER), the prospective tertiary care hospital-based Interdisciplinary Melanoma Cooperative Group (IMCG) biorepository, and the Cancer Genome Atlas (TCGA) biospecimen database to test the association of patient age at time of melanoma diagnosis with clinicopathologic features and survival outcomes...
October 19, 2016: Journal of Translational Medicine
https://www.readbyqxmd.com/read/27756426/exosomes-in-tumor-microenvironment-novel-transporters-and-biomarkers
#18
Zhen Wang, Jun-Qiang Chen, Jin-Lu Liu, Lei Tian
Tumor microenvironment (TME) plays an integral part in the biology of cancer, participating in tumor initiation, progression, and response to therapy. Exosome is an important part of TME. Exosomes are small vesicles formed in vesicular bodies with a diameter of 30-100 nm and a classic "cup" or "dish" morphology. They can contain microRNAs, mRNAs, DNA fragments and proteins, which are shuttled from a donor cell to recipient cells. Exosomes secreted from tumor cells are called tumor-derived (TD) exosomes. There is emerging evidence that TD exosomes can construct a fertile environment to support tumor proliferation, angiogenesis, invasion and premetastatic niche preparation...
October 19, 2016: Journal of Translational Medicine
https://www.readbyqxmd.com/read/27738348/forecasting-and-prediction-of-scorpion-sting-cases-using-a-sarima-model-in-biskra-province-algeria
#19
Schehrazad Selmane, Mohamed L'Hadj
OBJECTIVES: This study aims to highlight some epidemiological aspects of scorpion envenomations, to analyse and interpret the recorded data, and to develop a forecasting model for scorpion sting cases in Biskra province which records the highest number of scorpion stings at national level. METHODS: In addition to the epidemiological profile of scorpion stings that occurred throughout the year 2013, we carried out the Box-Jenkins approach to fit a seasonal autoregressive integrated moving average (SARIMA) model to the monthly recorded scorpion sting cases in Biskra from 2000 to 2012...
October 14, 2016: Epidemiology and Health
https://www.readbyqxmd.com/read/27737646/maternal-vitamin-d-supplementation-during-pregnancy-and-lactation-to-prevent-acute-respiratory-infections-in-infancy-in-dhaka-bangladesh-mdari-trial-protocol-for-a-prospective-cohort-study-nested-within-a-randomized-controlled-trial
#20
Shaun K Morris, Lisa G Pell, Mohammed Ziaur Rahman, Michelle C Dimitris, Abdullah Mahmud, M Munirul Islam, Tahmeed Ahmed, Eleanor Pullenayegum, Tahmid Kashem, Shaila S Shanta, Jonathan Gubbay, Eszter Papp, Michelle Science, Stanley Zlotkin, Daniel E Roth
BACKGROUND: Early infancy is a high-risk period for severe acute respiratory infection (ARI), particularly in low-income countries with resource-limited health systems. Lower respiratory tract infection (LRTI) is commonly preceded by upper respiratory infection (URTI), and often caused by respiratory syncytial virus (RSV), influenza and other common community-acquired viral pathogens. Vitamin D status is a candidate modifiable early-life determinant of the host antiviral immune response and thus may influence the risk of ARI-associated morbidity in high-risk populations...
October 13, 2016: BMC Pregnancy and Childbirth
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