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Prostatic adenocarcinoma

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https://www.readbyqxmd.com/read/28214571/encountering-dropped-gallstones-during-robotic-assisted-laparoscopic-radical-prostatectomy
#1
Lisa Brubaker, Michael Allgaeuer, Baris Turkbey, Peter Pinto, Abhinav Sidana
We describe a case of an unusual finding during robotic-assisted laparoscopic radical prostatectomy and bilateral pelvic lymphadenectomy in a 66-year-old male with Stage IIb (T2c, N0, M0) prostate adenocarcinoma. During the operation, intraperitoneal examination of the rectovesical pouch revealed calcifications and stones which were subsequently identified as gallstones. While these stones were not noted initially on this patient's preoperative multiparametric MRI (mpMRI), a retrospective review demonstrated hypointense foci in the rectovesical pouch...
February 15, 2017: Urology
https://www.readbyqxmd.com/read/28196067/body-weight-trajectories-and-risk-of-oesophageal-and-gastric-cardia-adenocarcinomas-a-pooled-analysis-of-nih-aarp-and-plco-studies
#2
Jessica L Petrick, Scott P Kelly, Linda M Liao, Neal D Freedman, Barry I Graubard, Michael B Cook
BACKGROUND: Elevated body mass index (BMI, kg m(-2)) has been consistently associated with oesophageal adenocarcinoma (EA) and gastric cardia adenocarcinoma (GCA) incidence. However, effects of adiposity over the life course in relation to EA/GCA have not been thoroughly explored. METHODS: We pooled two prospective cohort studies: NIH-AARP Diet and Health Study and Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, with data on 409 796 individuals (633 EA, 415 GCA)...
February 14, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28195088/serotonin-receptor-4-5-hydroxytryptamine-receptor-type-4-regulates-expression-of-estrogen-receptor-beta-and-cell-migration-in-hormone-naive-prostate-cancer
#3
Yasuhiro Nakamura, Kazue Ise, Yuto Yamazaki, Fumiyoshi Fujishima, Keely M McNamara, Hironobu Sasano
BACKGROUND: Estrogens are considered to potentially play some roles in the development and progression of prostate cancer through estrogen receptor beta (ERβ). However, additional factors which could influence the clinical outcome of the patients through modulating these steroid signalings have also been proposed. Among these, increased expression of serotonin receptor especially that of 5-hydroxytryptamine receptor Type 4 (5-HTR4) has been recently proposed to be involved in autocrine/paracrine mechanisms of castration-resistant prostate cancer, but the presence and clinical significance of 5-HTR4 in hormone-naive prostate cancer (HNPC) and its interaction with hormonal signaling pathways have remained virtually unknown...
January 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/28193700/the-nuclear-transport-receptor-importin-11-is-a-tumor-suppressor-that-maintains-pten-protein
#4
Muhan Chen, Dawid G Nowak, Navneet Narula, Brian Robinson, Kaitlin Watrud, Alexandra Ambrico, Tali M Herzka, Martha E Zeeman, Matthias Minderer, Wu Zheng, Saya H Ebbesen, Kendra S Plafker, Carlos Stahlhut, Victoria M Y Wang, Lorna Wills, Abu Nasar, Mireia Castillo-Martin, Carlos Cordon-Cardo, John E Wilkinson, Scott Powers, Raffaella Sordella, Nasser K Altorki, Vivek Mittal, Brendon M Stiles, Scott M Plafker, Lloyd C Trotman
Phosphatase and tensin homologue (PTEN) protein levels are critical for tumor suppression. However, the search for a recurrent cancer-associated gene alteration that causes PTEN degradation has remained futile. In this study, we show that Importin-11 (Ipo11) is a transport receptor for PTEN that is required to physically separate PTEN from elements of the PTEN degradation machinery. Mechanistically, we find that the E2 ubiquitin-conjugating enzyme and IPO11 cargo, UBE2E1, are limiting factors for PTEN degradation...
February 13, 2017: Journal of Cell Biology
https://www.readbyqxmd.com/read/28191651/the-development-of-prostate-adenocarcinoma-in-a-transgender-male-to-female-patient-could-estrogen-therapy-have-played-a-role
#5
Asma Sharif, Neha R Malhotra, Andres M Acosta, Andre A Kajdacsy-Balla, Maarten Bosland, Grace Guzman, Gail S Prins, Michael R Abern
BACKGROUND: Prostate adenocarcinoma (PCa) is a rare diagnosis in the male to female transgender (MtFT) population with only a few case reports published in the current medical literature. Long standing beliefs of androgen suppression conferring a protective effect against prostate cancer development have been challenged by the literature citing adenocarcinoma development in the prostate of rodent models following combined estrogen and testosterone treatment. MATERIALS AND METHODS: We herein present a MtFT patient who presented with high grade PCa following 20 years of exogenous estrogen therapy...
February 13, 2017: Prostate
https://www.readbyqxmd.com/read/28188816/a-chemical-genomics-approach-to-drug-reprofiling-in-oncology-antipsychotic-drug-risperidone-as-a-potential-adenocarcinoma-treatment
#6
Suzanne J Dilly, Andrew J Clark, Andrew Marsh, Daniel A Mitchell, Ricky Cain, Colin W G Fishwick, Paul C Taylor
Drug reprofiling is emerging as an effective paradigm for discovery of cancer treatments. Herein, an antipsychotic drug is immobilised using the Magic Tag(®) chemical genomics tool and screened against a T7 bacteriophage displayed library of polypeptides from Drosophila melanogaster, as a whole genome model, to uncover an interaction with a section of 17-β-HSD10, a proposed prostate cancer target. A computational study and enzyme inhibition assay with full length human 17-β-HSD10 identifies risperidone as a drug reprofiling candidate...
February 8, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28185762/biochemical-control-and-toxicity-for-favorable-and-intermediate-risk-patients-using-real-time-intraoperative-inverse-optimization-prostate-seed-implant-less-is-more
#7
G Shukla, A Sarkar, A Hanlon, E Crockett, H C Chen, J Martelli-Raben, A Glick, B Benge, M Lobis, S Terranova, T Desperito, D Cozzolino, E Kemmerer, F Mourtada, A Raben
PURPOSE: To report the biochemical control rate and clinical outcomes with real-time inverse planning (inverse optimization prostate seed implant [IO-PSI]) for favorable-risk (FR) and intermediate-risk (IR) prostate adenocarcinoma in a community practice setting. This analysis is an extended followup of our initial report, with favorable early biochemical control rate (biochemical nonevidence of disease) of 97% at 4 years. METHODS AND MATERIALS: Three hundred fifty-seven evaluable patients with FR and IR prostate cancer underwent real-time IO-PSI (iodine-125/145 Gy or palladium-103/120 Gy) between 2001 and 2013...
February 6, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28159676/transformation-of-prostatic-adenocarcinoma-to-well-differentiated-neuroendocrine-tumor-after-hormonal-treatment
#8
Syed Gilani, Charles C Guo, Elsa M Li-Ning, Curtis Pettaway, Patricia Troncoso
Carcinoid tumor of the prostate is extremely rare. Here we report a unique case of prostate cancer that underwent complete transformation from conventional adenocarcinoma to carcinoid-like tumor shortly after androgen deprivation treatment (ADT). The patient was a 59years old man who presented with lower urinary tract symptoms. His biopsy specimen demonstrated a high-grade prostatic adenocarcinoma with mixed acinar and ductal features. After ADT for 6months, the patient underwent radical prostatectomy. The post-ADT tumor showed monotonous neoplastic cells with fine granular chromatin forming rosette-like structures, resembling a carcinoid tumor...
January 31, 2017: Human Pathology
https://www.readbyqxmd.com/read/28157696/resveratrol-induces-mitochondria-mediated-caspase-independent-apoptosis-in-murine-prostate-cancer-cells
#9
Sanjay Kumar, Erdal Eroglu, James A Stokes, Karyn Scissum-Gunn, Sabita N Saldanha, Udai P Singh, Upender Manne, Selvarangan Ponnazhagan, Manoj K Mishra
Found in the skins of red fruits, including grapes, resveratrol (RES) is a polyphenolic compound with cancer chemopreventive activity. Because of this activity, it has gained interest for scientific investigations. RES inhibits tumor growth and progression by targeting mitochondria-dependent or -independent pathways. However, further investigations are needed to explore the underlying mechanisms.The present study is focused on examining the role of RES-induced, mitochondria-mediated, caspase-independent apoptosis of prostate cancer cells, namely transgenic adenocarcinoma of mouse prostate (TRAMP) cells...
February 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28155999/accuracy-of-grading-gleason-score-7-prostatic-adenocarcinoma-on-needle-biopsy-influence-of-percent-pattern-4-and-other-histological-factors
#10
Abdelrazak Meliti, Evita Sadimin, Mario Diolombi, Francesca Khani, Jonathan I Epstein
BACKGROUND: Recognition of Gleason pattern 4 in prostatic needle biopsies is crucial for both prognosis and therapy. Recently, it has been recommended to record percent pattern 4 when Gleason score 7 cancer is the highest grade in a case. METHODS: Four hundred and five prostate needle core biopsies received for a second opinion at our institution from February-June, 2015 were prospectively diagnosed with prostatic adenocarcinoma Gleason score 7 as the highest score on review by a consultant urological pathologist...
February 3, 2017: Prostate
https://www.readbyqxmd.com/read/28155149/lectin-histochemistry-for-metastasizing-and-non-metastasizing-cancer-cells
#11
Gerrit Wolters-Eisfeld, Udo Schumacher
Changes in glycosylation of the cancer cell glycocalyx are a hallmark of metastasizing cancers and critically contribute to distant metastasis. In this chapter we concentrate on two lectins capable of specifically binding tumor-associated glycans in cryostat or formalin-fixed, paraffin-embedded tissue sections derived from primary clinical material, genetically engineered mouse models with endogenous cancer formation or xenograft mouse models. The snail lectin of Helix pomatia (HPA) binds N-acetylgalactosamine (GalNAc) that is expressed among others as Tn antigen (O-linked GalNAc) in primary tumors and metastases in several human adenocarcinomas...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28144985/socs3-immunohistochemical-expression-seems-to-support-the-2005-and-2014-international-society-of-urological-pathology-isup-modified-gleason-grading-system
#12
Francesco Pierconti, Maurizio Martini, Tonia Cenci, Gian Luigi Petrone, Riccardo Ricci, Emilio Sacco, Pier Francesco Bassi, Luigi Maria Larocca
BACKGROUND: In the 2014, The International Society of Urological Pathology (ISUP) consensus conference update the grading of prostate, last revised in 2005. In this study we evaluate the SOCS3 immunohistochemical protein expression in different Gleason prostatic adenocarcinoma: classical Gleason grade 3, classical Gleason grade 3 upgraded to Gleason grade 4 according to the ISUP modifications and classical and modified Gleason grade 4. The major conclusions were: (i) Cribriform glands should be assigned a Gleason pattern 4, regardless of morphology; (ii) Glomeruloid glands should be assigned a Gleason pattern 4, regardless of morphology; (iii) Grading of mucinous carcinoma of the prostate should be based on its underlying growth pattern rather than all as pattern 4; and (iv) Intraductal carcinoma of the prostate without invasive carcinoma should not assigned Gleason grade and a comment about aggressive carcinoma probably associated should be made...
February 1, 2017: Prostate
https://www.readbyqxmd.com/read/28138408/kidney-ultrasound-what-is-important-for-a-urologist
#13
REVIEW
Tomasz Szopiński, Elżbieta Keller, František Záťura
Kidney ultrasound is one of the basic procedures in the practice of a urologist. Apart from the location and the size, description of renal morphology should contain the thickness of the anterior lip parenchyma in a transverse section and the location of possible narrowings. Uneven outline of the kidney is a sign of past inflammatory conditions. In the case of the pelvicalyceal system dilation, it is advised to specify the dimensions of the pelvis and calyces. Convex shape of the calyces proves elevated pressure within the pelvicalyceal system...
December 2016: Journal of Ultrasonography
https://www.readbyqxmd.com/read/28138401/t-cadherin-in-prostate-cancer-relationship-with-cancer-progression-differentiation-and-drug-resistance
#14
Boris Dasen, Tatjana Vlajnic, Chantal Mengus, Christian Ruiz, Lukas Bubendorf, Giulio Spagnoli, Stephen Wyler, Paul Erne, Thérèse J Resink, Maria Philippova
Prostate cancer represents the second leading cause of cancer-related death in men. T-cadherin (CDH13) is an atypical GPI-anchored member of the cadherin family of adhesion molecules. Its gene was reported to be downregulated in a small series of prostate tumours. T-cadherin protein expression/localisation in prostate tissue has never been investigated. The purpose of our study was to analyse CDH13 gene and protein levels in large sets of healthy and cancer prostate tissue specimens and evaluate CDH13 effects on the sensitivity of prostate cancer cells to chemotherapy...
January 2017: Journal of Pathology. Clinical Research
https://www.readbyqxmd.com/read/28134934/ck2-abrogates-the-inhibitory-effects-of-prh-hhex-on-prostate-cancer-cell-migration-and-invasion-and-acts-through-prh-to-control-cell-proliferation
#15
Y H Siddiqui, R M Kershaw, E H Humphreys, E M Assis Junior, S Chaudhri, P-S Jayaraman, K Gaston
PRH/HHEX (proline-rich homeodomain protein/haematopoietically expressed homeobox protein) is a transcription factor that controls cell proliferation, cell differentiation and cell migration. Our previous work has shown that in haematopoietic cells, Protein Kinase CK2-dependent phosphorylation of PRH results in the inhibition of PRH DNA-binding activity, increased cleavage of PRH by the proteasome and the misregulation of PRH target genes. Here we show that PRH and hyper-phosphorylated PRH are present in normal prostate epithelial cells, and that hyper-phosphorylated PRH levels are elevated in benign prostatic hyperplasia, prostatic adenocarcinoma, and prostate cancer cell lines...
January 30, 2017: Oncogenesis
https://www.readbyqxmd.com/read/28133356/-laparoscopic-resection-in-a-case-of-local-recurrence-of-rectal-cancer
#16
Kiminori Yanagisawa, Shinichi Yoshioka, Mutsumi Fukunaga, Shoko Honda, Ryohei Yukimoto, Shinji Tokuyama, Akina Saito, Kazuyuki Okada, Ken Konishi, Hideo Ota, Shigekazu Yokoyama, Hirofumi Miki, Kenji Kobayashi
A 65-year-old man had undergone high anterior resection for rectal cancer. Seven years after the surgery, a liver metastasis was identified, and the metastasis was surgically resected. A year after the liver surgery, blood testing showed high carcinoembryonic antigen(CEA). A fluorodeoxyglucose(FDG) / -positron emission tomography(PET)/CT examination showed a high FDG accumulation at the rectal anastomosis site, and we diagnosed local recurrence of rectal cancer and prostate invasion. Because there were no distant metastases, he underwent laparoscopic lower anterior resection, radical prostatectomy, and ileostomy...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133080/-a-case-of-advanced-rectal-cancer-in-which-combined-prostate-removal-and-isr-using-the-da-vinci-surgical-system-with-preoperative-chemotherapy-allowed-curative-resection
#17
Hideaki Kawakita, Kenji Katsumata, Kenta Kasahara, Hiroshi Kuwabara, Masatoshi Shigoka, Takaaki Matsudo, Masanobu Enomoto, Tetsuo Ishizaki, Masayuki Hisada, Kazuhiko Kasuya, Akihiko Tsuchida
A 53-year-old male presented with a chief complaint of dyschezia.Lower gastrointestinal endoscopy confirmed the presence of a type II tumor in the lower part of the rectum, and a biopsy detected a well-differentiated adenocarcinoma.As invasion of the prostate and levator muscle of the anus was suspected on diagnostic imaging, surgery was performed after preoperative chemotherapy.With no clear postoperative complications, the patient was discharged 26 days after surgery. After 24 months, the number of urination ranged from 1 to 6, with a Wexner score of 6 and a mild desire to urinate in the absence of incontinence...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28132904/cellular-retinoid-binding-proteins-crbp-crabp-fabp5-effects-on-retinoid-metabolism-function-and-related-diseases
#18
REVIEW
Joseph L Napoli
Cellular binding-proteins (BP), including CRBP1, CRBP2, CRABP1, CRABP2, and FABP5, shepherd the poorly aqueous soluble retinoids during uptake, metabolism and function. Holo-BP promote efficient use of retinol, a scarce but essential nutrient throughout evolution, by sheltering it and its major metabolite all-trans-retinoic acid from adventitious interactions with the cellular milieu, and by imposing specificity of delivery to enzymes, nuclear receptors and other partners. Apo-BP reflect cellular retinoid status and modify activities of retinoid metabolon enzymes, or exert non-canonical actions...
January 27, 2017: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28130121/synthesis-and-structure-activity-studies-on-novel-analogs-of-human-growth-hormone-releasing-hormone-ghrh-with-enhanced-inhibitory-activities-on-tumor-growth
#19
Marta Zarandi, Renzhi Cai, Magdolna Kovacs, Petra Popovics, Luca Szalontay, Tengjiao Cui, Wei Sha, Miklos Jaszberenyi, Jozsef Varga, XianYang Zhang, Norman L Block, Ferenc G Rick, Gabor Halmos, Andrew V Schally
The syntheses and biological evaluations of new GHRH analogs of Miami (MIA) series with greatly increased anticancer activity are described. In the design and synthesis of these analogs, the following previous substitutions were conserved: D-Arg(2), Har(9), Abu(15), and Nle(27). Most new analogs had Ala at position 8. Since replacements of both Lys(12) and Lys(21) with Orn increased resistance against enzymatic degradation, these modifications were kept. The substitutions of Arg at both positions 11 and 20 by His were also conserved...
January 24, 2017: Peptides
https://www.readbyqxmd.com/read/28130102/variant-histology-and-clinicopathologic-features-of-prostate-cancer-in-men-aged-50-years-treated-with-radical-prostatectomy
#20
Susan Prendeville, Michael E Nesbitt, Andrew J Evans, Neil E Fleshner, Theodorus H van der Kwast
PURPOSE: While prostate cancer (PCa) is primarily a disease of older men, young-age PCa represents an important clinical subgroup which has not been adequately studied. We evaluated the histopathological features and associated clinical behavior of PCa in a cohort of younger men treated with radical prostatectomy (RP). MATERIALS AND METHODS: The study included 171 men aged <50 years with PCa treated with RP at an academic institution between 2001-2015. Comprehensive pathology review was performed...
January 24, 2017: Journal of Urology
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