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Prostatic adenocarcinoma

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https://www.readbyqxmd.com/read/28081573/-prostate-carcinoma-mimics-lung-carcinoma-a-case-report
#1
Konstantinos Drosos, Klaus Höfner
A PSA-negative, advanced adenocarcinoma of the prostate is a rare finding. Expression of thyroid transcription factor-1 (TTF-1) in the tumour in combination with a previous medical history of lung adenocarcinoma could complicate the final diagnosis. To the best of our knowledge, we present the second case of a TTF-1-positive, acinar adenocarcinoma of the prostate.We present the case of a 65-year-old male with surgically treated lung adenocarcinoma; 3 years later we diagnosed adenocarcinoma of the bladder and prostate...
January 12, 2017: Aktuelle Urologie
https://www.readbyqxmd.com/read/28074780/mri-directed-cognitive-fusion-guided-biopsy-of-the-anterior-prostate-tumors
#2
Ian G Murphy, Elaine NiMhurchu, Robert G Gibney, Colm J McMahon
PURPOSE: We aimed to evaluate the efficacy of magnetic resonance imaging (MRI)-directed cognitive fusion transrectal ultrasonography (TRUS)-guided anterior prostate biopsy for diagnosis of anterior prostate tumors and to illustrate this technique. METHODS: A total of 39 patients with previous negative TRUS biopsy, but high clinical suspicion of occult prostate cancer, prospectively underwent prostate MRI including diffusion-weighted imaging (DWI). Patients with a suspicious anterior lesion on MRI underwent targeted anterior gland TRUS guided biopsy with cognitive fusion technique using sagittal probe orientation...
January 11, 2017: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
https://www.readbyqxmd.com/read/28073878/foamy-gland-variant-of-adenocarcinoma-of-prostate-a-rare-pathological-variant
#3
Aditi Arora, Ritika Jaiswal, Nidhi Anand, Nuzhat Husain
No abstract text is available yet for this article.
January 10, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28073298/extraperitoneal-vs-transperitoneal-robot-assisted-radical-prostatectomy-in-the-setting-of-prior-abdominal-or-pelvic-surgery
#4
David Horovitz, Changyong Feng, Edward M Messing, Jean Volny Joseph
INTRODUCTION: During Robotic-Assisted Radical Prostatectomy (RARP), the prostate may be approached extraperiteoneally (eRARP) or transperitoneally (tRARP). The former avoids the abdominal cavity which might be of benefit in patients who have had prior abdominal or pelvic surgery (PAPS). Our objective was to compare the outcomes of patients with PAPS undergoing either technique. METHODS: A retrospective review of patients treated with RARP from July 1, 2003-Dec. 31, 2014 with a minimum follow-up of 3 months was undertaken...
January 10, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28072762/giving-axl-the-axe-targeting-axl-in-human-malignancy
#5
Carl M Gay, Kavitha Balaji, Lauren Averett Byers
The receptor tyrosine kinase AXL, activated by a complex interaction between its ligand growth arrest-specific protein 6 and phosphatidylserine, regulates various vital cellular processes, including proliferation, survival, motility, and immunologic response. Although not implicated as an oncogenic driver itself, AXL, a member of the TYRO3, AXL, and MERTK family of receptor tyrosine kinases, is overexpressed in several haematologic and solid malignancies, including acute myeloid leukaemia, non-small cell lung cancer, gastric and colorectal adenocarcinomas, and breast and prostate cancers...
January 10, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28059767/rb1-and-trp53-cooperate-to-suppress-prostate-cancer-lineage-plasticity-metastasis-and-antiandrogen-resistance
#6
Sheng Yu Ku, Spencer Rosario, Yanqing Wang, Ping Mu, Mukund Seshadri, Zachary W Goodrich, Maxwell M Goodrich, David P Labbé, Eduardo Cortes Gomez, Jianmin Wang, Henry W Long, Bo Xu, Myles Brown, Massimo Loda, Charles L Sawyers, Leigh Ellis, David W Goodrich
Prostate cancer relapsing from antiandrogen therapies can exhibit variant histology with altered lineage marker expression, suggesting that lineage plasticity facilitates therapeutic resistance. The mechanisms underlying prostate cancer lineage plasticity are incompletely understood. Studying mouse models, we demonstrate that Rb1 loss facilitates lineage plasticity and metastasis of prostate adenocarcinoma initiated by Pten mutation. Additional loss of Trp53 causes resistance to antiandrogen therapy. Gene expression profiling indicates that mouse tumors resemble human prostate cancer neuroendocrine variants; both mouse and human tumors exhibit increased expression of epigenetic reprogramming factors such as Ezh2 and Sox2...
January 6, 2017: Science
https://www.readbyqxmd.com/read/28054315/the-missing-link-in-the-diagnostic-pathway-of-prostate-cancer
#7
Arne Vidar Tind Wøyen, Gergely Laczkó, Søren Høyer, Laszlo Hegyi
Prostate cancer is one of the most common cancers in the Western world. It is among the leading causes of cancer related death. While its incidence and survival increased significantly during the last few decades in Denmark, the mortality rate did not change for patients younger than 80 year old. Development of new techniques, such as multiparametric MRI, helps to increase the accuracy of diagnosis. However, a missing link in the diagnostic pathway may result in mistreatment if an acinar adenocarcinoma of prostate is transformed into a neuroendocrine phenotype such as small cell carcinoma...
January 4, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28053055/cancer-incidence-and-mortality-risks-in-a-large-us-barrett-s-oesophagus-cohort
#8
Michael B Cook, Sally B Coburn, Jameson R Lam, Philip R Taylor, Jennifer L Schneider, Douglas A Corley
OBJECTIVE: Barrett's oesophagus (BE) increases the risk of oesophageal adenocarcinoma by 10-55 times that of the general population, but no community-based cancer-specific incidence and cause-specific mortality risk estimates exist for large cohorts in the USA. DESIGN: Within Kaiser Permanente Northern California (KPNC), we identified patients with BE diagnosed during 1995-2012. KPNC cancer registry and mortality files were used to estimate standardised incidence ratios (SIR), standardised mortality ratios (SMR) and excess absolute risks...
January 4, 2017: Gut
https://www.readbyqxmd.com/read/28050428/malignant-ascites-due-to-prostatic-adenocarcinoma-an-extremely-rare-manifestation-of-a-common-disease
#9
Stamatis S Papadatos, George Bazoukis, Georgios Deligiannis, Stefanos Mylonas, Christos Zissis
No abstract text is available yet for this article.
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28047178/th-ab-202-12-the-first-clinical-implementation-of-a-real-time-six-degree-of-freedom-tracking-system-during-radiation-therapy
#10
D Nguyen, J Kim, R O'Brien, C Huang, J Booth, P Greer, K Legge, P Poulsen, J Martin, P Keall
PURPOSE: In current practice, imaging is typically performed prior to treatment; the cancer target motion during treatment is unknown. We present the first clinical implementation of real time Kilovoltage Intrafraction Monitoring (KIM) system which tracks the cancer target translational and rotational motions during treatment. METHODS: KIM technology: KIM estimates the 3D position of the target tumour based on segmented 2D positions of the three implanted fiducials in each of the kV images (125 kV, 10 mA at 11 fps) taken continuously during the treatment arc...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28045729/68ga-psma-pet-ct-in-a-rare-case-of-metastatic-adenocarcinoma-prostate-presenting-as-numb-chin-syndrome
#11
Arun Sasikumar, Ajith Joy, M R A Pillai, Renuka Gopal, Boben Thomas
A 68-year-old man presented with right-side facial numbness. MRI showed an extra-axial mass infiltrating the right temporal bone. It was debulked surgically, and histopathology revealed metastatic adenocarcinoma. Ga PSMA PET/CT done in view of increased PSA levels and clinically suspicious hard lesion in prostate showed primary lesion in left side of prostate with metastases to the right temporal bone. Primary carcinoma of the prostate and metastases to the right temporal bone were proven histopathologically...
December 30, 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28044303/acinar-adenocarcinoma-of-prostate-with-predominant-ttf-1-positive-intraductal-component
#12
Banu Sarsik, Nisar Karadeniz, Adnan Şimşir, Rahmi Akyol, Kutsal Yörükoğlu, Sait Şen
Intraductal carcinoma of prostate has been previously described in radical prostatectomies. It's rarely encountered in needle biopsies in the absence of infiltrative carcinoma. But, both histogenesis and nomenclature of the lesion is still controversial. Among the pure intraductal carcinoma of prostate cases, a different solid patern was described with smaller nuclei at the center of the ducts. However, there is a lack of information about the association of those cases with acinar prostate adenocarcinoma. Herein, we describe a case of acinar adenocarcinoma with predominant non-neuroendocrine TTF-1 positive small cell intraductal component...
2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28042313/efficient-enhancement-of-blood-brain-barrier-permeability-using-acoustic-cluster-therapy-act
#13
Andreas K O Åslund, Sofie Snipstad, Andrew Healey, Svein Kvåle, Sverre H Torp, Per C Sontum, Catharina de Lange Davies, Annemieke van Wamel
The blood-brain barrier (BBB) is a major obstacle in drug delivery for diseases of the brain, and today there is no standardized route to surpass it. One technique to locally and transiently disrupt the BBB, is focused ultrasound in combination with gas-filled microbubbles. However, the microbubbles used are typically developed for ultrasound imaging, not BBB disruption. Here we describe efficient opening of the BBB using the promising novel Acoustic Cluster Therapy (ACT), that recently has been used in combination with Abraxane® to successfully treat subcutaneous tumors of human prostate adenocarcinoma in mice...
2017: Theranostics
https://www.readbyqxmd.com/read/28039265/safety-tolerability-and-preliminary-activity-of-lb-100-an-inhibitor-of-protein-phosphatase-2a-in-patients-with-relapsed-solid-tumors
#14
John S Kovach, Vincent Chung, Aaron S Mansfield, Fadi Braiteh, Donald Richards, Henry Durivage, Richard S Ungerleider, Francis Johnson
PURPOSE: To determine the maximum tolerated dose and to assess the safety, tolerability, and potential activity of LB-100, a first-in-class small molecule inhibitor of protein phosphatase 2A (PP2A) in adult patients with progressive solid tumors. EXPERIMENTAL DESIGN: LB-100 was administered intravenously daily for 3 days in 21-day cycles in a 3+3 dose-escalation design. RESULTS: There were 29 patient entries over 7 dose escalations. One patient stopped treatment after one dose because of an acute infection and was re-enrolled after recovery; each course was analyzed as a separate patient entry...
December 30, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28034818/clivus-metastasis-of-a-duodenal-adenocarcinoma-a-case-report-and-literature-review
#15
REVIEW
Simone E Dekker, Jay Wasman, Kevin K Yoo, Fernando Alonso, Robert W Tarr, Nicholas C Bambakidis, Kenneth Rodriguez
BACKGROUND: Clival metastases of adenocarcinomas are exceptionally rare tumors, especially when they arise from the small intestine. To our knowledge, here we present first report of a metastasis of a duodenal adenocarcinoma to the clivus. We also present a systematic review detailing metastasis to the clivus. METHODS: Studies were identified using the search terms clivus metastasis, skull base metastasis, and clivus in PubMed. We collected the following information: histopathology of the primary tumor, symptoms, history, treatment, and follow up...
December 26, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/28033274/differential-diagnosis-of-prostate-cancer-and-noncancerous-tissue-in-the-peripheral-zone-and-central-gland-using-the-quantitative-parameters-of-dce-mri-a-meta-analysis
#16
Peng Gao, Changzheng Shi, Lianping Zhao, Quan Zhou, Liangping Luo
BACKGROUND: The objective of this meta-analysis was to evaluate the clinical usefulness of K, Kep, and Ve values in the differential diagnosis of prostate cancer (PCa) and noncancerous tissue in the peripheral zone (PZ) and central gland (CG). METHODS: A search was conducted of the PubMed, MEDLINE, EMBASE, Cochrane Library, China National Knowledge Infrastructure, and Wanfang databases from January 2000 to October 2015 using the search terms "prostate cancer," " dynamic contrast-enhanced (DCE)," "magnetic resonance imaging," "K," "Kep," and "Ve...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28032857/heme-oxygenase-1-in-the-forefront-of-a-multi-molecular-network-that-governs-cell-cell-contacts-and-filopodia-induced-zippering-in-prostate-cancer
#17
Alejandra V Paez, Carla Pallavicini, Federico Schuster, Maria Pia Valacco, Jimena Giudice, Emiliano G Ortiz, Nicolás Anselmino, Estefania Labanca, Maria Binaghi, Marcelo Salierno, Marcelo A Martí, Javier H Cotignola, Anna Woloszynska-Read, Luciana Bruno, Valeria Levi, Nora Navone, Elba S Vazquez, Geraldine Gueron
Prostate cancer (PCa) cells display abnormal expression of cytoskeletal proteins resulting in an augmented capacity to resist chemotherapy and colonize distant organs. We have previously shown that heme oxygenase 1 (HO-1) is implicated in cell morphology regulation in PCa. Here, through a multi 'omics' approach we define the HO-1 interactome in PCa, identifying HO-1 molecular partners associated with the integrity of the cellular cytoskeleton. The bioinformatics screening for these cytoskeletal-related partners reveal that they are highly misregulated in prostate adenocarcinoma compared with normal prostate tissue...
December 29, 2016: Cell Death & Disease
https://www.readbyqxmd.com/read/28030797/galeterone-and-its-analogs-inhibit-mnk-eif4e-axis-synergize-with-gemcitabine-impede-pancreatic-cancer-cell-migration-invasion-and-proliferation-and-inhibit-tumor-growth-in-mice
#18
Andrew K Kwegyir-Afful, Francis N Murigi, Puranik Purushottamachar, Vidya P Ramamurthy, Marlena S Martin, Vincent C O Njar
Survival rate for pancreatic cancer (pancreatic ductal adenocarcinoma, PDAC) is poor, with about 80% of patients presenting with the metastatic disease. Gemcitabine, the standard chemotherapeutic agent for locally advanced and metastatic PDAC has limited efficacy, attributed to innate/acquired resistance and activation of pro-survival pathways. The Mnk1/2-eIF4E and NF-κB signaling pathways are implicated in PDAC disease progression/metastasis and also associated with gemcitabine-induced resistance in PDAC...
December 24, 2016: Oncotarget
https://www.readbyqxmd.com/read/28028835/timp4-expression-is-regulated-by-mir-200b-3p-in-prostate-cancer-cells
#19
Marek Janiak, Wiktor Paskal, Beata Rak, Filip Garbicz, Robert Jarema, Krzysztof Sikora, Paweł Włodarski
In prostate cancer TIMP4 expression level fluctuates with tumor progression. The mechanism and factors influencing its expression remain unclear. The aim of the study was to test the hypothesis on regulation of TIMP4 by microRNA-200b-3p. The levels of TIMP4 and miR-200b-3p expression were determined by real time PCR in 27 prostate carcinomas and eight benign prostatic hyperplasia samples. We found that miR-200b-3p positively correlated with TIMP4 expression in cancer samples (r = 0.46; p < 0.02). Moreover, mean miR-200b-3p level and TIMP4 expression were both higher in cancer tissues compared to benign prostatic hyperplasia samples (p > 0...
December 28, 2016: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/28017535/bilateral-testicular-metastases-and-filariasis-in-prostatic-adenocarcinoma
#20
Monica Malik, Deepa Joseph, Jyothi Jonnadula, Syed Fayaz Ahmed, Deepthi Valiyaveettil, Rama Vaghmare
No abstract text is available yet for this article.
December 7, 2016: Clinical Genitourinary Cancer
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