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Spectralis

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https://www.readbyqxmd.com/read/27915343/intravitreal-dexamethasone-implant-for-the-treatment-of-postoperative-macular-edema
#1
André Klamann, Katharina Böttcher, Philipp Ackermann, Gerd Geerling, Marc Schargus, Rainer Guthoff
INTRODUCTION: Macular edema after cataract surgery (Irvine-Gass syndrome) or pars plana vitrectomy is a postoperative complication which can lead to permanent visual loss. Increased inflammatory substances, such as prostaglandins and cytokines, are discussed to be causative. Currently, there are no evidence-based guidelines for the treatment of postoperative macular edema. Intravitreal dexamethasone (DEX) could be effective by its anti-inflammatory effect. We examined the functional and morphological results of treatment with 0...
December 3, 2016: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/27893521/lower-tear-meniscus-measurements-using-a-new-anterior-segment-swept-source-optical-coherence-tomography-and-agreement-with-fourier-domain-optical-coherence-tomography
#2
Pedro Arriola-Villalobos, José Ignacio Fernández-Vigo, David Díaz-Valle, Jaime Almendral-Gómez, Cristina Fernández-Pérez, José M Benítez-Del-Castillo
PURPOSE: To assess intraobserver repeatability and interobserver and intersession reproducibility of lower tear meniscus height (LTMH) measurements obtained using a new anterior segment swept-source optical coherence tomography (SS-OCT) device. Agreement with Fourier-domain (FD) OCT (Spectralis) was also examined. METHODS: In an observational cross-sectional study, one eye of 29 healthy subjects was randomly imaged with both devices at our center. Two examiners then randomly measured the LTMH using the software's calipers...
November 23, 2016: Cornea
https://www.readbyqxmd.com/read/27867714/automatic-identification-of-the-temporal-retinal-nerve-fiber-raphe-from-macular-cube-data
#3
Phillip Bedggood, Fumi Tanabe, Allison M McKendrick, Andrew Turpin
We evaluated several approaches for automatic location of the temporal nerve fiber raphe from standard macular cubes acquired on a Heidelberg Spectralis OCT. Macular cubes with B-scan separation of 96-122 µm were acquired from 15 healthy participants, and "high density" cubes with scan separation of 11 µm were acquired from the same eyes. These latter scans were assigned to experienced graders for subjective location of the raphe, providing the ground truth by which to compare methods operating on the lower density data...
October 1, 2016: Biomedical Optics Express
https://www.readbyqxmd.com/read/27864062/en-face-optical-coherence-tomography-imaging-for-the-detection-of-nascent-geographic-atrophy
#4
Karen B Schaal, Giovanni Gregori, Philip J Rosenfeld
PURPOSE: To determine if en face optical coherence tomography (OCT) imaging can identify nascent geographic atrophy (nGA) in eyes with intermediate age-related macular degeneration (iAMD). DESIGN: Retrospective observational case series. METHODS: Patients with iAMD from the COMPLETE study at the Bascom Palmer Eye Institute were evaluated to determine if nGA was present at baseline and at follow-up using high density Spectralis OCT B-scans and en face OCT images from the Cirrus OCT instrument...
November 15, 2016: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/27860529/a-comparison-of-central-corneal-thicknesses-measured-with-two-different-methods-in-cases-of-primary-open-angle-glaucoma
#5
Fatih Mehmet Adibelli, Halit Oğuz, Tuğba Göncü, Omer Faruk Yilmaz, Funda Yuksekyayla
Accurate and repeatable measurement of the central cornea thickness (CCT) is important in terms of follow-up of glaucoma patients. The aim of this study was to compare CCT measurements made with an ultrasonic pachymeter (USP) and with the Spectralis Anterior Segment Module optical coherence tomography (OCT) device. The study included 52 eyes of 26 primary open-angle glaucoma patients. CCT measurements were taken with the USP device and then with the OCT by imaging cornea slices. The mean CCT was measured as 555...
November 18, 2016: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/27852400/-diagnostic-performance-of-laser-retinal-imaging-in-the-epiretinal-membrane
#6
Y J Huo, L L Yang, W B Wei
Objective: To determine the diagnostic performance of confocal scanning laser ophthalmoscope (cSLO)-based retinal imaging in the epiretinal membrane (ERM) patients. Methods: Prospective case series study. Twenty-six patients (32 eyes) with ERM determined by spectral domain optical coherence tomography (SD-OCT) were recruited from June 2015 to October 2015 in the Beijing Tongren Eye Center. All subjects underwent retinal imaging using the cSLO-based Heidelberg MultiColor (Spectralis HRA-2; Heidelberg Engineering) technology and the traditional color fundus camera...
November 11, 2016: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/27818206/automated-segmentation-errors-when-using-optical-coherence-tomography-to-measure-retinal-nerve-fiber-layer-thickness-in-glaucoma
#7
Steven L Mansberger, Shivali Menda, Brad Fortune, Stuart K Gardiner, Shaban Demirel
PURPOSE: To characterize the error of optical coherence tomography (OCT) measurements of retinal nerve fiber layer (RNFL) thickness when using automated retinal layer segmentation algorithms without manual refinement. DESIGN: cross-sectional study METHODS: Setting: glaucoma clinical practice. STUDY POPULATION: 3490 scans from 412 eyes of 213 individuals with a diagnosis of glaucoma or glaucoma suspect. Observational Procedures: We used spectral domain OCT (Spectralis, Heidelberg Engineering, Heidelberg, Germany) to measure RNFL thickness in a 6-degree peripapillary circle, and exported the native 'automated segmentation only' results...
November 3, 2016: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/27817115/-ant-egg-cataract-revisited
#8
Kåre Clemmensen, Jan J Enghild, Anders Ivarsen, Ruth Riise, Henrik Vorum, Steffen Heegaard
PURPOSE: Hereditary congenital cataract varies immensely concerning location and form of the lens opacities. A specific and very rare phenotype is called "ant-egg" cataract first described in 1900. "Ant-eggs" have previously been examined using light microscopy, backscattered electron imaging and X-ray scans and electron microscopy. The purpose of this study was to further characterize "ant-egg" cataract using modern technology and display the history of the "ant-eggs" after cataract extraction...
November 5, 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/27793604/association-of-pediatric-choroidal-neovascular-membranes-at-the-temporal-edge-of-optic-nerve-and-retinochoroidal-coloboma
#9
Dilraj S Grewal, Du Tran Viet, Lejla Vajzovic, Prithvi Mruthyunjaya, Cynthia A Toth
PURPOSE: To describe the characteristics of pediatric choroidal neovascular membranes (CNV) associated with retinochoroidal and optic nerve coloboma using optical coherence tomography (OCT) and their response to treatment. DESIGN: Retrospective case series. METHODS: Retrospective review of children <16 years with CNV and retinochoroidal and optic-nerve coloboma from 1995-2015 who underwent OCT imaging using either hand-held (Bioptigen, Morrisville, NC) or table-top OCT (Spectralis, Heidelberg, Carlsbad, CA) RESULTS: Eight eyes of 8 patients (3 males, 5 females) with a mean age of 4...
October 25, 2016: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/27780174/clinical-spectrum-of-macular-foveal-capillaries-evaluated-with-optical-coherence-tomography-angiography
#10
Maria V Cicinelli, Adriano Carnevali, Alessandro Rabiolo, Lea Querques, Ilaria Zucchiatti, Vincenzo Scorcia, Francesco Bandello, Giuseppe Querques
PURPOSE: To describe macular-foveal capillaries (MFC) by means of optical coherence tomography angiography and to identify the clinical spectrum of this angiographic feature. METHODS: Patients with MFC presenting at the Medical Retina & Imaging Unit of the Department of Ophthalmology, University Vita-Salute San Raffaele in Milan were recruited. Patients underwent a complete ophthalmologic examination that included slit-lamp examination, fundus examination, measurement of best-corrected visual acuity, fundus autofluorescence, and spectral-domain optical coherence tomography (Spectralis HRA + OCT; Heidelberg Engineering, Heidelberg, Germany)...
July 12, 2016: Retina
https://www.readbyqxmd.com/read/27775222/monitoring-macular-pigment-changes-in-macular-holes-using-fluorescence-lifetime-imaging-ophthalmoscopy
#11
Lydia Sauer, Sven Peters, Johanna Schmidt, Dietrich Schweitzer, Matthias Klemm, Lisa Ramm, Regine Augsten, Martin Hammer
PURPOSE: To investigate the impact of macular pigment (MP) on fundus autofluorescence (FAF) lifetimes in vivo by characterizing full-thickness idiopathic macular holes (MH) and macular pseudo-holes (MPH). METHODS: A total of 37 patients with MH and 52 with MPH were included. Using the fluorescence lifetime imaging ophthalmoscope (FLIO), based on a Heidelberg Engineering Spectralis system, a 30° retinal field was investigated. FAF decays were detected in a short (498-560 nm; ch1) and long (560-720 nm; ch2) wavelength channel...
October 24, 2016: Acta Ophthalmologica
https://www.readbyqxmd.com/read/27768203/comprehensive-three-dimensional-analysis-of-the-neuroretinal-rim-in-glaucoma-using-high-density-spectral-domain-optical-coherence-tomography-volume-scans
#12
Edem Tsikata, Ramon Lee, Eric Shieh, Huseyin Simavli, Christian J Que, Rong Guo, Ziad Khoueir, Johannes de Boer, Teresa C Chen
Purpose: To describe spectral-domain optical coherence tomography (OCT) methods for quantifying neuroretinal rim tissue in glaucoma and to compare these methods to the traditional retinal nerve fiber layer thickness diagnostic parameter. Methods: Neuroretinal rim parameters derived from three-dimensional (3D) volume scans were compared with the two-dimensional (2D) Spectralis retinal nerve fiber layer (RNFL) thickness scans for diagnostic capability. This study analyzed one eye per patient of 104 glaucoma patients and 58 healthy subjects...
October 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27750291/a-qualitative-and-quantitative-assessment-of-fundus-autofluorescence-patterns-in-patients-with-choroideremia
#13
Jasleen K Jolly, Thomas L Edwards, Jonathan Moules, Markus Groppe, Susan M Downes, Robert E MacLaren
Purpose: We set out to characterize the pattern of fundus autofluorescence (AF) loss in choroideremia (CHM) patients of varying ages and disease severity in order to determine the average rate of progression of this potential disease biomarker. Methods: Fifty consecutive CHM patients (100 eyes) attending outpatient clinics at Oxford Eye Hospital underwent analysis with the Heidelberg OCT Spectralis with autofluorescence capabilities. The area of residual AF was traced using Heidelberg Eye Explorer...
August 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27682504/optic-nerve-head-slope-based-quantitative-parameters-for-identifying-open-angle-glaucoma-on-spectralis-oct-images
#14
Abdel-Razzak M Al-Hinnawi, Bassam O Al-Naami, Motasem M Al-Latayfeh
PURPOSE: To investigate monitoring slope-based features of the optic nerve head (ONH) cup as open-angle glaucoma (OAG) occurs. METHOD: A dataset of 46 retrospective OCT cases was acquired from the SPECTRALIS Heidelberg Engineering OCT device. A set of five parameters, which are based on the ONH cup-incline, are measured on the OAG and normal subjects in the dataset. Then, three new ONH cup-shape indices were deduced. The ONH cup-incline parameters and ONH cup-shape indices are analyzed to estimate their clinical value...
September 28, 2016: International Ophthalmology
https://www.readbyqxmd.com/read/27646327/spectral-versus-time-domain-oct-in-detecting-preoperative-epiretinal-membranes-that-accompany-macular-holes
#15
Prethy Rao, Yoshihiro Yonekawa, Benjamin J Thomas, Kimberly A Drenser
PURPOSE: To compare the sensitivities of spectral-domain optical coherence tomography (SD-OCT) versus time-domain OCT (TD-OCT) in identifying epiretinal membranes (ERM) preoperatively in patients who underwent surgery for full-thickness macular holes (FTMH). METHODS: This is an interventional retrospective case series of 59 eyes diagnosed with FTMHs who underwent 25-G pars plana vitrectomy with internal limiting membrane peeling between 2009 and 2015. Preoperative OCTs were obtained by SD-OCT (Spectralis, Heidelberg, Germany) or TD-OCT (Stratus, Carl Zeiss Meditec, Dublin, CA, USA)...
September 17, 2016: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/27642539/enhancement-of-corneal-visibility-in-optical-coherence-tomography-images-with-corneal-opacification
#16
Cheuk Wang Chung, Marcus Ang, Mohamed Farook, Nicholas G Strouthidis, Joddhbir S Mehta, Jean Martial Mari, Michaël J A Girard
PURPOSE: To establish and to rank the performance of a corneal adaptive compensation (CAC) algorithm in enhancing corneal images with scars acquired from three commercially available anterior segment optical coherence tomography (ASOCT) devices. METHODS: Horizontal B-scans of the cornea were acquired from 10 patients using three ASOCT devices (Spectralis, RTVue, and Cirrus). We compared ASOCT image quality (with and without CAC) by computing the intralayer contrast (a measure of shadow removal), the interlayer contrast (a measure of tissue boundary visibility), and the tissue/background contrast (a measure of overall corneal visibility)...
September 2016: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/27636592/bruch-s-membrane-opening-minimum-rim-width-assessment-with-spectral-domain-optical-coherence-tomography-performs-better-than-confocal-scanning-laser-ophthalmoscopy-in-discriminating-early-glaucoma-patients-from-control-subjects
#17
Anani P Toshev, Julia Lamparter, Norbert Pfeiffer, Esther M Hoffmann
PURPOSE: To compare the diagnostic performance and evaluate diagnostic agreement for early glaucoma detection between a confocal scanning laser ophthalmoscope (CSLO) and a spectral-domain optical coherence tomography (SD-OCT). PATIENTS AND METHODS: Fifty-five eyes of 55 open-angle glaucoma patients and 42 eyes of 42 healthy control subjects were enrolled in this observational, cross-sectional study. All participants underwent comprehensive ophthalmic examination, visual field testing, and optic nerve head and retinal nerve fiber layer imaging by CSLO (HRT3) and SD-OCT (Spectralis OCT)...
September 15, 2016: Journal of Glaucoma
https://www.readbyqxmd.com/read/27632583/safety-and-feasibility-of-a-novel-25-gauge-biodegradable-implant-of-dexamethasone-for-treatment-of-macular-edema-associated-with-retinal-vein-occlusion-a-phase-i-clinical-trial
#18
Renato B Cunha, Rubens C Siqueira, André Messias, Ingrid U Scott, Silvia Ligorio Fialho, Armando da Silva Cunha-Junior, Rodrigo Jorge
PURPOSE: To evaluate the safety and feasibility of a 25-gauge biodegradable implant containing 350 μg of dexamethasone (DDS-25) for the treatment of decreased vision due to macular edema associated with central or branch retinal vein occlusion. METHODS: Prospective, nonrandomized, open-label, Phase I clinical trial, including 10 patients with decreased vision (best-corrected early treatment diabetic retinopathy study visual acuity of 20/40 or worse) due to macular edema associated with central retinal vein occlusion (n = 4) or branch retinal vein occlusion (n = 6) for more than 4 months...
September 14, 2016: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/27622495/time-course-of-changes-in-choroidal-thickness-after-complete-mydriasis-induced-by-compound-tropicamide-in-children
#19
Zhouyue Li, Junwen Zeng, Wei Jin, Wen Long, Weizhong Lan, Xiao Yang
PURPOSE: The aim of this study was to investigate the time-course of changes in choroidal thickness (ChT) following complete mydriasis induced by compound tropicamide. METHODS: ChT was measured by OCT with the enhanced-depth imaging technique (Spectralis HRA+OCT, Heidelberg Engineering, Germany) at nine locations of the fundus: subfoveal ChT (SFChT) and ChT at 1 mm and 3 mm from the fovea in four quadrants. Mydriasis was induced with compound tropicamide (0.5% tropicamide plus 0...
2016: PloS One
https://www.readbyqxmd.com/read/27620473/the-assessment-of-choroidal-thickness-with-spectral-domain-optical-coherence-tomography-during-valsalva-maneuver
#20
AyşeÖzköse Çiçek, Necati Duru, Zeynep Duru, Orhan Altunel, Arzu Seyhan Karatepe Haşhaş, Hasan Basri Arifoğlu, Bedirhan Alabay, Mustafa Ataş
PURPOSE: The purpose of the study was to evaluate the effect of Valsalva maneuver (VM) on choroidal thickness. METHODS: All the volunteers underwent a detailed opthalmic examination. Third-generation Spectralis OCT device (software version 5.6.3.0; Spectralis OCT, Heidelberg Engineering, Dossenheim, Germany) was used for assessment. Subfoveal and perifoveal CT of all volunteers were measured by using EDI-OCT technology. Perifoveal CT was measured 1500 µm nasally and 1500 µm temporally apart from the foveal center...
September 12, 2016: International Ophthalmology
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