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https://www.readbyqxmd.com/read/28108905/the-assessment-of-macular-electrophysiology-and-macular-morphology-in-patients-with-vitiligo
#1
Rukiye Aydin, Mustafa Ozsutcu, Sevil Karaman Erdur, Funda Dikkaya, Ali Balevi, Merve Ozbek, Fevzi Senturk
PURPOSE: We aimed to analyze the electrophysiologic function and morphology of macula in vitiligo patients. METHODS: Seventeen patients with vitiligo and 11 healthy subjects were studied. All participants underwent multifocal electroretinography (mfERG) and spectral domain optical coherence tomography (SD-OCT) evaluations. The mfERG (P1 mfERG responses central and peripheral) and retinal layer segmentation parameters (nine ETDRS subfields) were compared in vitiligo and control groups...
January 21, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28107458/neuropilin-1-involvement-in-choroidal-and-retinal-neovascularisation
#2
Patricia Fernández-Robredo, Senthil Selvam, Michael B Powner, Dawn A Sim, Marcus Fruttiger
PURPOSE: Inhibiting VEGF is the gold standard treatment for neovascular age-related macular degeneration (AMD). It is also effective in preventing retinal oedema and neovascularisation (NV) in diabetic retinopathy (DR) and retinal vein occlusions (RVO). Neuropilin 1 (Nrp1) is a co-receptor for VEGF and many other growth factors, and therefore a possible alternative drug target in intra ocular neovascular disease. Here we assessed choroidal and retinal NV in an inducible, endothelial specific knock out model for Nrp1...
2017: PloS One
https://www.readbyqxmd.com/read/28101049/tuberculous-subretinal-abscess-in-a-non-hiv-patient-with-miliary-tuberculosis
#3
Eugenia Paez Soria, Paula Magnano, Ariel Schlaen, Paula Luvini, Gisela Arevalo Calderon, Mauricio Martinez Cartier, Pablo Chiaradía, Cristóbal Couto
This case report describes the features of a tuberculous subretinal abscess in a non-HIV patient. It includes the characterization of the lesion with spectral-domain optical coherence tomography (SD-OCT) and fundus autofluorescence examination. SD-OCT and autofluorescence imaging showed external retinal involvement during development of the tuberculous subretinal abscess. Patients with tuberculous lesions need a multidisciplinary approach, since the disease may involve any part of the body. In this case in particular, incidental findings at computed tomography scan led to the detection of this rare ocular manifestation of tuberculous disease...
September 2016: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/28097437/two-and-three-dimensional-topographic-analysis-of-pathologically-myopic-eyes-with-dome-shaped-macula-and-inferior-staphyloma-by-spectral-domain-optical-coherence-tomography
#4
Antonio García-Ben, Radua Kamal-Salah, Ignacio García-Basterra, Ana Gonzalez Gómez, María José Morillo Sanchez, Jose Manuel García-Campos
PURPOSE: To investigate the posterior anatomical structure of pathologically myopic eyes with dome-shaped macula and inferior staphyloma using spectral domain optical coherence tomography (SD-OCT). METHODS: Our database of 260 pathologically myopic eyes was analyzed retrospectively to identify patients with dome-shaped macula and inferior staphyloma. All patients underwent vertical and horizontal SD-OCT scans across the central fovea, with three-dimensional macular map reconstruction...
January 17, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28095089/comparative-data-on-sd-oct-for-a-retinal-nerve-fiber-layer-and-retinal-macular-thickness-in-a-large-cohort-with-marfan-syndrome
#5
WanWan Xu, Sudhi P Kurup, Amani A Fawzi, Mary K Durbin, Irene H Maumenee, Marilyn B Mets
PURPOSE: To report the distribution of macular and optic nerve topography in the eyes of individuals with Marfan syndrome aged 8-56 years using spectral domain optical coherence tomography (SD-OCT). METHODS: Thirty-three patients with Marfan syndrome underwent a full eye examination including slit-lamp biomicroscopy, indirect ophthalmoscopy, and axial length measurement; and SD-OCT measurements of the retinal nerve fiber layer (RNFL) and macular thickness. RESULTS: For patients between the ages of 8 and 12 years, the average RNFL thickness is 98 ± 9 μm, the vertical cup to disc (C:D) ratio is 0...
January 17, 2017: Ophthalmic Genetics
https://www.readbyqxmd.com/read/28093579/progression-of-transsynaptic-retinal-degeneration-with-spectral-domain-optical-coherence-tomography
#6
Stephen G Schwartz, Armando Monroig, Harry W Flynn
PURPOSE: To illustrate the progression of retrograde transsynaptic retinal degeneration using spectral- domain optical coherence tomography (SD-OCT). OBSERVATIONS: A 60 year-old man with a stroke was followed over a 17-month period using SD-OCT of the macula, ganglion cell layer (GCC), and retinal nerve fiber layer. Transsynaptic retinal degeneration progressed over this time. CONCLUSIONS AND IMPORTANCE: Retrograde transsynaptic retinal degeneration may occur in patients with homonymous visual field loss caused by post-geniculate neurologic disease...
April 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/28092396/agreement-between-three-optical-coherence-tomography-devices-to-assess-the-insertion-distance-and-thickness-of-horizontal-rectus-muscles
#7
Lucía De-Pablo-Gómez-de-Liaño, José Ignacio Fernández-Vigo, Néstor Ventura-Abreu, Julián García-Feijóo, José Ángel Fernández-Vigo, Rosario Gómez-de-Liaño
PURPOSE: To assess the agreement between two different spectral domain (SD-OCT) and one swept source (SS-OCT) optical coherence tomography device to measure the insertion distance and the thickness of the horizontal rectus muscles. METHODS: Seventy eyes from 35 healthy patients were studied. Three OCT instruments-Spectralis (Heidelberg Engineering Inc., Heidelberg, Germany), Cirrus 5000 (Carl Zeiss Meditec, Dublin, CA), and Triton (Topcon, Inc., Tokyo, Japan)-were used to measure the limbus insertion distance and the thickness of the lateral rectus and medial rectus muscles...
January 13, 2017: Journal of Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/28068435/adaptive-optics-reveals-photoreceptor-abnormalities-in-diabetic-macular-ischemia
#8
Peter L Nesper, Fabio Scarinci, Amani A Fawzi
Diabetic macular ischemia (DMI) is a phenotype of diabetic retinopathy (DR) associated with chronic hypoxia of retinal tissue. The goal of this prospective observational study was to report evidence of photoreceptor abnormalities using adaptive optics scanning laser ophthalmoscopy (AOSLO) in eyes with DR in the setting of deep capillary plexus (DCP) non-perfusion. Eleven eyes from 11 patients (6 women, age 31-68), diagnosed with DR without macular edema, underwent optical coherence tomography angiography (OCTA) and AOSLO imaging...
2017: PloS One
https://www.readbyqxmd.com/read/28068388/the-association-between-foveal-morphology-and-macular-pigment-spatial-distribution-an-ethnicity-study
#9
Irene Ctori, Byki Huntjens
PURPOSE: Macular pigment (MP) spatial distribution varies considerably among individuals. We investigated ethnic variations in MP spatial distribution in relation to foveal architecture. METHODS: We measured MP optical density (MPOD) using heterochromatic flicker photometry (MAP test, City, University of London) in 76 white, 80 South Asian and 70 black volunteers (18 to 39 years). MPOD spatial profiles were classified objectively as exponential, ring-like or central dip, based on deviations away from an exponential fit...
2017: PloS One
https://www.readbyqxmd.com/read/28055101/high-resolution-imaging-of-intraretinal-structures-in-active-and-resolved-central-serous-chorioretinopathy
#10
Ryan N Vogel, Christopher S Langlo, Drew Scoles, Joseph Carroll, David V Weinberg, Judy E Kim
Purpose: We improved our understanding of central serous chorioretinopathy (CSC), we performed an analysis of noninvasive, high-resolution retinal imaging in patients with active and resolved CSC. Methods: Adaptive optics scanning light ophthalmoscopy (AOSLO) and spectral-domain optical coherence tomography (SD-OCT) were performed on five subjects with CSC. A custom AOSLO system was used to simultaneously collect confocal and split-detector images. Spectral domain-OCT volume scans were used to create en face views of various retinal layers, which then were compared to montaged AOSLO images after coregistration...
January 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28053503/assessment-of-ischemia-in-acute-central-retinal-vein-occlusion-from-inner-retinal-reflectivity-on-spectral-domain-optical-coherence-tomography
#11
David J Browning, Omar S Punjabi, Chong Lee
PURPOSE: To determine the relationship between different spectral domain optical coherence tomography (SD-OCT) signs of retinal ischemia in acute central retinal vein occlusion (CRVO) and whether they predict anterior segment neovascularization (ASNV). DESIGN: Retrospective, observational study. SUBJECTS: Thirty-nine consecutive patients with acute CRVO and 12 months of follow-up. METHODS: We graded baseline SD-OCTs for increased reflectivity of the inner retina, loss of definition of inner retinal layers, presence of a prominent middle-limiting membrane (p-MLM) sign, and presence of paracentral acute middle maculopathy (PAMM)...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28051361/spectral-domain-optical-coherence-tomography-an-in-vivo-imaging-protocol-for-assessing-retinal-morphology-in-adult-zebrafish
#12
Maria Toms, Dhani Tracey-White, Dhakshi Muhundhakumar, Lina Sprogyte, Adam M Dubis, Mariya Moosajee
The present study outlines a protocol for examining retinal structure in zebrafish, a popular model organism for ocular studies, using spectral domain optical coherence tomography (SD-OCT). We demonstrate how this live imaging modality can be used to obtain high quality images of several retinal features, including the optic nerve, retinal vasculature, and the cone photoreceptor mosaic. Retinal histology sections were obtained from imaged fish for comparison with SD-OCT cross-sectional B-scans. Voronoi domain analysis was used to assess cone photoreceptor packing regularity at 3, 6, and 12 months...
January 4, 2017: Zebrafish
https://www.readbyqxmd.com/read/28043309/visual-and-anatomical-outcomes-following-idiopathic-macular-epiretinal-membrane-surgery
#13
Bashiran Shahzadi, Syed Fawad Rizvi, Kanwal Latif, Faisal Murtaza, Saliha Naz
OBJECTIVE: To assess the visual and anatomical outcomes following idiopathic macular epiretinal membrane (IERM) surgery. STUDY DESIGN: Case series. PLACE AND DURATION OF STUDY: Layton Rehmatulla Benevolent Trust (L.R.B.T), Free Base Eye Hospital, Karachi, from January 2015 to June 2016. METHODOLOGY: Thirty eyes of thirty patients affected with idiopathic macular epiretinal membrane stage 2 were enrolled in this study...
December 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28042632/macular-thickness-in-healthy-saudi-adults-a-spectral-domain-optical-coherence-tomography-study
#14
Waseem M Al-Zamil, Fahad M Al-Zwaidi, Sanaa A Yassin
To determine the macular thickness in the eyes of healthy Saudi adults using spectral-domain optical coherence tomography (SD-OCT). Methods: This is a prospective, cross-sectional study, including 158 healthy participants between August and December 2015. Mean subject age was 29.9 ± 7.85 years old. All participants underwent full ophthalmic evaluation, including SD-OCT imaging, and axial length measurement. Data from the right eye were included. Mean retinal thickness was determined. Correlations between retinal thickness and gender, age, axial length, and spherical equivalence were analyzed...
January 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/28042184/the-palisades-of-vogt-in-congenital-corneal-opacification-an-american-ophthalmological-society-thesis
#15
Ken K Nischal, Kira L Lathrop
PURPOSE: The purposes of this study are first, to determine if the palisades of Vogt (POV) are present or absent in cases of congenital corneal opacification (CCO) by using spectral domain ocular coherence tomography (SD-OCT), and second, in those cases already undergoing penetrating keratoplasty (PKP), to see whether the absence or presence of POV corresponds to re-epithelialization following transplant. METHODS: This was a retrospective case review of 20 eyes (10 normal, 10 with CCO) evaluated with SD-OCT...
August 2016: Transactions of the American Ophthalmological Society
https://www.readbyqxmd.com/read/28032805/nerve-fiber-layer-thickness-and-characteristics-associated-with-glaucoma-in-community-living-older-adults-prelude-to-a-screening-trial
#16
Barbara E K Klein, Chris A Johnson, Stacy M Meuer, Kyungmoo Lee, Andreas Wahle, Kristine E Lee, Amruta Kulkarni, Milan Sonka, Michael D Abràmoff, Ronald Klein
PURPOSE: To examine the associations of nerve fiber layer (NFL) thickness with other ocular characteristics in older adults. METHODS: Participants in the Beaver Dam Eye Study (2008-2010) underwent spectral domain optical coherence tomography (SD-OCT) scans of the optic nerve head, imaging of optic discs, frequency doubling technology (FDT) perimetry, measurement of intraocular pressure (IOP), and an interview concerning their history of glaucoma and use of drops to lower eye pressure...
December 29, 2016: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/28030536/effect-of-refractive-correction-error-on-retinal-nerve-fiber-layer-thickness-a-spectralis-optical-coherence-tomography-study
#17
Xiaoli Ma, Yutong Chen, Xianjie Liu, Hong Ning
BACKGROUND Identifying and assessing retinal nerve fiber layer defects are important for diagnosing and managing glaucoma. We aimed to investigate the effect of refractive correction error on retinal nerve fiber layer (RNFL) thickness measured with Spectralis spectral-domain optical coherence tomography (SD-OCT). MATERIAL AND METHODS We included 68 participants: 32 healthy (normal) and 36 glaucoma patients. RNFL thickness was measured using Spectralis SD-OCT circular scan. Measurements were made with a refractive correction of the spherical equivalent (SE), the SE+2...
December 28, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28029294/corneal-thickness-of-eyes-of-healthy-goats-sheep-and-alpacas-manually-measured-by-use-of-a-portable-spectral-domain-optical-coherence-tomography-device
#18
Alexander J LoPinto, Chris G Pirie, Daniela Bedenice, Sandra L Ayres
OBJECTIVE To determine corneal thickness of eyes of healthy goats, sheep, and alpacas by use of a portable spectral-domain optical coherence tomography (SD-OCT) device and evaluate intraoperator reliability for measurements. ANIMALS 11 female goats, 10 female sheep, and 11 (4 males and 7 females) alpacas. PROCEDURES Each animal was sedated, and gentle manual restraint was used to ensure proper positioning of the head and globe. Corneal pachymetry was performed (in triplicate) with a portable SD-OCT device on both eyes of each animal...
January 2017: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/28028739/multimodal-imaging-in-a%C3%A2-case-of-bilateral-outer-retinitis-associated-with-mumps-infection
#19
Rim Kahloun, Hager Ben Amor, Imen Ksiaa, Sourour Zina, Bechir Jelliti, Salim Ben Yahia, Moncef Khairallah
PURPOSE: To report the results of multimodal imaging of acute outer retinitis associated to mumps infection. METHODS: A patient with mumps-associated outer retinitis evaluated by color fundus photography, spectral domain optical coherence tomography (SD-OCT), optical coherence tomography angiography, fundus autofluorescence (FAF), fluorescein angiography (FA), and indocyanine green angiography (ICGA). RESULTS: We report a case of a 12-year-old boy who developed bilateral outer retinitis related to mumps...
December 27, 2016: International Ophthalmology
https://www.readbyqxmd.com/read/28018740/multimodal-registration-of-sd-oct-volumes-and-fundus-photographs-using-histograms-of-oriented-gradients
#20
Mohammad Saleh Miri, Michael D Abràmoff, Young H Kwon, Mona K Garvin
With availability of different retinal imaging modalities such as fundus photography and spectral domain optical coherence tomography (SD-OCT), having a robust and accurate registration scheme to enable utilization of this complementary information is beneficial. The few existing fundus-OCT registration approaches contain a vessel segmentation step, as the retinal blood vessels are the most dominant structures that are in common between the pair of images. However, errors in the vessel segmentation from either modality may cause corresponding errors in the registration...
December 1, 2016: Biomedical Optics Express
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