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https://www.readbyqxmd.com/read/27911114/changes-of-tangential-traction-after-macular-peeling-correlation-between-en-face-analysis-and-macular-sensitivity
#1
Mario R Romano, Gilda Cennamo, Ida Cesarano, Domenico Cardone, Giuseppe Nicoletti, Rodolfo Mastropasqua, Giovanni Cennamo
PURPOSE: To assess the epi- and intra-retinal morphology changes of the tangential tractions following vitreoretinal surgery for epiretinal membranes and to investigate the correlation between the depth of retinal changes and functional macular sensitivity (MS). METHODS: This is a prospective cross-sectional interventional study, in which 73 eyes of 73 patients with diagnosis of idiopathic epiretinal membrane (iERM) were evaluated. All patients received complete ophthalmic evaluation, including axial and en-face scanning spectral domain-optical coherence tomography (SD-OCT) analysis and microperimetry...
December 2, 2016: Current Eye Research
https://www.readbyqxmd.com/read/27905337/choroidal-thickness-evaluation-of-healthy-eyes-central-serous-chorioretinopathy-and-fellow-eyes-using-spectral-domain-optical-coherence-tomography-in-indian-population
#2
Supriya Arora, Richa Pyare, Preethi Sridharan, Tarun Arora, Meenakshi Thakar, Basudeb Ghosh
AIM: The purpose of this study is to establish a normative database of subfoveal choroidal thickness (CT) in healthy young Indians using spectral domain optical coherence tomography (SD OCT). Evaluation and comparison of CT of central serous chorioretinopathy (CSC) and fellow eyes were also performed. MATERIALS AND METHODS: This was a prospective, cross-sectional, and observational study. It included 112 normal eyes of 112 healthy volunteers who had no evidence of ocular or systemic disease, 84 CSC eyes with acute, treatment-naïve CSC, and 69 fellow eyes with no evidence of neurosensory detachment or pigment epithelium detachment on SD OCT...
October 2016: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/27905330/screening-for-chloroquine-maculopathy-in-populations-with-uncertain-reliability-in-outcomes-of-automatic-visual-field-testing
#3
Paradee Kunavisarut, Pimploy Chavengsaksongkram, Aniki Rothova, Kessara Pathanapitoon
PURPOSE: The purpose of this study was to compare screening methods for the early detection of maculopathy in patients treated with chloroquine (CQ) or hydroxychloroquine (HCQ) and to identify the risk factors for the development of toxic maculopathy. METHODS: We performed a prospective study of all 217 patients taking CQ and/or HCQ and seen in our center between July 2011 and December 2013. All subjects underwent a complete ocular examination, as well as spectral domain optical coherence tomography (SD-OCT), fundus autofluorescence (FAF), and 10-2 Humphrey visual field (10-2 HVF)...
October 2016: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/27897119/glaucoma-hot-topics-in-pharmacology
#4
Shiama I Balendra, Parth Arvind Shah, Mishank Jain, Andrzej Grzybowski, Francesca M Cordeiro
BACKGROUND: Glaucoma comprises a group of neurodegenerative diseases resulting in retinal ganglion cell death within the optic nerve head. It is projected to affect almost 80 million people worldwide by 2020. The condition's asymptomatic nature translates to over half of glaucoma sufferers being unaware of their condition. By the time of diagnosis, irreversible blindness is likely to have occurred. Prime areas of glaucoma research therefore include identification and optimization of risk factors for the disease, accurate and early diagnostic tools and novel therapeutic methods...
November 29, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27893108/choroidal-thickness-influences-near-infrared-reflectance-intensity-in-eyes-with-geographic-atrophy-due-to-age-related-macular-degeneration
#5
Rosa Dolz-Marco, Orly Gal-Or, K Bailey Freund
Purpose: To evaluate the effects of retinal and choroidal thickness on near-infrared reflectance (NIR) scanning laser ophthalmoscopy in eyes with geographic atrophy (GA) secondary to non-neovascular age-related macular degeneration (AMD). Methods: This was a cross-sectional review of the clinical records and multimodal imaging data of eyes diagnosed with GA secondary to non-neovascular AMD. Imaging modalities included color fundus photography, fundus autofluorescence, NIR, and structural spectral-domain optical coherence tomography (SD-OCT)...
November 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27889502/role-of-lamellar-hole-associated-epiretinal-proliferation-in-lamellar-macular-holes
#6
Roberto dell'Omo, Gianni Virgili, Stanislao Rizzo, Serena De Turris, Giovanni Coclite, Dario Giorgio, Ermanno dell'Omo, Ciro Costagliola
PURPOSE: To compare the morphologic and functional characteristics and response to surgery of lamellar macular holes (LMHs) with and without lamellar hole-associated epiretinal proliferation (LHEP) and standard epiretinal membrane (ERM). DESIGN: Retrospective observational case series. METHODS: Setting: Vitreoretinal clinical practice. STUDY POPULATION: Eigthy-four eyes of 84 patients. The included eyes must present an irregular foveal contour and schitic or cavitated lamellar separation of neurosensory retina on spectral-domain optical coherence tomography (SD-OCT) and an area of increased autofluorescence on blue- fundus autofluorescence (B-FAF)...
November 23, 2016: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/27886184/a-view-of-the-current-and-future-role-of-optical-coherence-tomography-in-the-management-of-age-related-macular-degeneration
#7
REVIEW
U Schmidt-Erfurth, S Klimscha, S M Waldstein, H Bogunović
Optical coherence tomography (OCT) has become an established diagnostic technology in the clinical management of age-related macular degeneration (AMD). OCT is being used for primary diagnosis, evaluation of therapeutic efficacy, and long-term monitoring. Computer-based advances in image analysis provide complementary imaging tools such as OCT angiography, further novel automated analysis methods as well as feature detection and prediction of prognosis in disease and therapy by machine learning. In early AMD, pathognomonic features such as drusen, pseudodrusen, and abnormalities of the retinal pigment epithelium (RPE) can be imaged in a qualitative and quantitative way to identify early signs of disease activity and define the risk of progression...
November 25, 2016: Eye
https://www.readbyqxmd.com/read/27881909/comparison-of-choroidal-thickness-measurements-between-spectral-domain-oct-and-swept-source-oct-in-normal-and-diseased-eyes
#8
Sidra Zafar, Ma Rehman Siddiqui, Rida Shahzad
PURPOSE: Sub-foveal choroidal thickness (SFCT) is affected in many ocular diseases. The aim of this study was to compare SFCT measurements between Topcon 3D 2000 spectral-domain optical coherence tomography (SD-OCT) and Topcon swept-source OCT (SS-OCT), with different laser wavelengths, in normal and diseased populations. MATERIALS AND METHODS: This was a prospective, cross-sectional, noninterventional study including 27 normal volunteers and 27 participants with retinal disease...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27871762/clinical-and-histopathologic-ocular-findings-in-disseminated-mycobacterium-chimaera-infection-after-cardiothoracic-surgery
#9
Sandrine A Zweifel, Daniela Mihic-Probst, Christine A Curcio, Daniel Barthelmes, Andrea Thielken, Peter M Keller, Barbara Hasse, Christian Böni
PURPOSE: To investigate and characterize clinical and histopathologic ocular findings in patients with disseminated infection with Mycobacterium chimaera, a slow-growing nontuberculous mycobacterium (NTM), subsequent to cardiothoracic surgery. DESIGN: Observational case series. PARTICIPANTS: Five white patients (10 eyes). METHODS: Analysis of clinical ocular findings, including visual acuity, slit-lamp biomicroscopy, spectral-domain optical coherence tomography (SD OCT), fundus autofluorescence (FAF), and fluorescein angiography/indocyanine green (ICG) angiography findings, of patients with a disseminated M...
November 18, 2016: Ophthalmology
https://www.readbyqxmd.com/read/27866331/photoreceptor-degeneration-by-intravitreal-injection-of-n-methyl-n-nitrosourea-mnu-in-rabbits-a-pilot-study
#10
Sarah Rösch, Claudia Werner, Frank Müller, Peter Walter
BACKGROUND: Pilot study on the attempt to induce selective photoreceptor degeneration in the rabbit eye by intravitreal injection of MNU, facing the difficulties of the evaluation of retinal degeneration by different in-vivo and in-vitro methods in such a large eye animal model. METHODS: Eight pigmented Chinchilla Bastard rabbits were injected intravitreally with MNU (1 × 1mg/kg body weight (BW), 1 × 2mg/kg BW, 3 × 3mg/kg BW, 1 × 4mg/kg BW, 1 × 6mg/kg BW, and 1 × DMSO + PBS as control)...
November 19, 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/27863845/macular-atrophy-in-neovascular-age-related-macular-degeneration-with-monthly-versus-treat-and-extend-ranibizumab-findings-from-the-trex-amd-trial
#11
Nizar S Abdelfattah, Mayss Al-Sheikh, Sean Pitetta, Ahmed Mousa, SriniVas R Sadda, Charles C Wykoff
PURPOSE: To compare the enlargement rate of macular atrophy (ERMA) in eyes treated with ranibizumab monthly or using a treat-and-extend (TREX) regimen for neovascular age-related macular degeneration (AMD) or fellow control eyes, as well as analyze risk factors for macular atrophy (MA) development and progression. DESIGN: Eighteen-month, multicenter, randomized, controlled clinical trial. PARTICIPANTS: Sixty patients with treatment-naïve neovascular AMD in 1 eye randomized 1:2 to monthly or TREX ranibizumab...
November 15, 2016: Ophthalmology
https://www.readbyqxmd.com/read/27861391/effect-of-age-and-sex-on-retinal-layer-thickness-and-volume-in-normal-eyes
#12
Jae Yon Won, Sung Eun Kim, Young-Hoon Park
The aim of the study was to evaluate the effect of sex and age on the thickness of the retinal layer in normal eyes using spectral-domain optical coherence tomography (SD-OCT).Fifty healthy subjects between the ages of 20 and 80 had their retinal layers measured using SD-OCT at Seoul St. Mary's Hospital. Mean thickness and volume were measured for 9 retinal layers in the fovea, the pericentral ring, and the peripheral ring. The differences of sex- and age-related thickness and volume in each retinal layer were analyzed...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27857487/macular-thickness-assessment-in-patients-with-glaucoma-and-its-correlation-with-visual-fields
#13
Mafalda Mota, Fernando T Vaz, Mário Ramalho, Catarina Pedrosa, Maria Lisboa, Paulo Kaku, Florindo Esperancinha
AIM: To determine the relationship between macular thickness (MT) and visual field (VF) parameters, as well as with changes in the retinal nerve fiber layer (RNFL) thickness in patients with glaucoma and ocular hypertension (OH). MATERIALS AND METHODS: Cross-sectional statistical analysis of spectral domain optical coherence tomography (SD-OCT) compared with several VF parameters (mean defect - MD and loss variance - LV), in a nonrandom sample of 70 eyes from patients with glaucoma or OH...
September 2016: Journal of Current Glaucoma Practice
https://www.readbyqxmd.com/read/27853297/changes-in-choroidal-thickness-follow-the-rnfl-changes-in-leber-s-hereditary-optic-neuropathy
#14
Enrico Borrelli, Giacinto Triolo, Maria Lucia Cascavilla, Chiara La Morgia, Giovanni Rizzo, Giacomo Savini, Nicole Balducci, Paolo Nucci, Rosa Giglio, Fatemeh Darvizeh, Vincenzo Parisi, Francesco Bandello, Alfredo A Sadun, Valerio Carelli, Piero Barboni
Leber's hereditary optic neuropathy (LHON) is typically characterized by vascular alterations in the acute phase. The aim of this study was to evaluate choroidal changes occurring in asymptomatic, acute and chronic stages of LHON. We enrolled 49 patients with LHON, 19 with Dominant Optic Atrophy (DOA) and 22 healthy controls. Spectral Domain-Optical Coherence Tomography (SD-OCT) scans of macular and peripapillary regions were performed in all subjects, to evaluate macular and peripapillary choroidal thickness, and retinal nerve fiber layer (RNFL) thicknes...
November 17, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27853025/paradoxical-thinning-of-the-retinal-nerve-fiber-layer-after-reversal-of-cupping-a-case-report-of-primary-infantile-glaucoma
#15
Ta Chen Chang, Alana L Grajewski
The circumpapillary retinal nerve fiber layer (RNFL) thickness was assessed by spectral domain optical coherent tomography (SD-OCT) before and after surgical reduction of intraocular pressure in an eye with primary infantile glaucoma. In this case, a postoperative reduction of cupping and a subsequent increase in neuroretinal rim area is associated with a paradoxical thinning of the RNFL. This is the first-known characterization of cupping reversal using SD-OCT.
September 2016: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/27852400/-diagnostic-performance-of-laser-retinal-imaging-in-the-epiretinal-membrane
#16
Y J Huo, L L Yang, W B Wei
Objective: To determine the diagnostic performance of confocal scanning laser ophthalmoscope (cSLO)-based retinal imaging in the epiretinal membrane (ERM) patients. Methods: Prospective case series study. Twenty-six patients (32 eyes) with ERM determined by spectral domain optical coherence tomography (SD-OCT) were recruited from June 2015 to October 2015 in the Beijing Tongren Eye Center. All subjects underwent retinal imaging using the cSLO-based Heidelberg MultiColor (Spectralis HRA-2; Heidelberg Engineering) technology and the traditional color fundus camera...
November 11, 2016: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/27847640/choroidal-thickness-in-older-patients-with-central-serous-chorioretinopathy
#17
Caio V Regatieri, Eduardo A Novais, Lauren Branchini, Mehreen Adhi, Emily D Cole, Ricardo Louzada, Mark Lane, Elias Reichel, Jay S Duker
BACKGROUND: To investigate the choroidal thickness in older patients with central serous chorioretinopathy (CSCR) compared to age-matched normal subjects. METHODS: Fifteen patients (30 eyes) with CSCR, all aged ≥60 years, and 21 age-matched normal subjects (21 eyes) underwent high-definition raster scanning using SD-OCT. Both eyes from CSCR patients were included in the analysis. The eyes in patients with CSCR were divided into two groups: active CSCR (17 eyes) if there was foveal-involving subretinal fluid and inactive contralateral eye group (13 eyes)...
2016: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/27847636/expanded-spectral-domain-oct-findings-in-the-early-detection-of-hydroxychloroquine-retinopathy-and-changes-following-drug-cessation
#18
David R Lally, Jeffrey S Heier, Caroline Baumal, Andre J Witkin, Steven Maler, Chirag P Shah, Elias Reichel, Nadia K Waheed, Igor Bussel, Adam Rogers, Jay S Duker
PURPOSE: To report expanded SD-OCT findings of HCQ retinopathy that may assist the clinician in earlier diagnosis. To characterize structural changes of HCQ retinopathy with SD-OCT after drug cessation. METHODS: Setting: Private practice and academic institution. Patient Population: Patients at New England Eye Center and Ophthalmic Consultants of Boston in Boston, MA diagnosed with HCQ retinopathy and followed after drug cessation. Retrospective clinical data review by the Boston Image Reading Center...
2016: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/27847627/visual-response-and-anatomical-changes-on-sequential-spectral-domain-optical-coherence-tomography-in-birdshot-chorioretinopathy-treated-with-local-corticosteroid-therapy
#19
Marisa Gobuty, Mehreen Adhi, Sarah P Read, Jay S Duker
BACKGROUND: Birdshot chorioretinopathy is a chronic bilateral inflammatory disease of unknown etiology characterized by bilateral retinal vasculitis, mild to moderate vitritis, retinal vascular leakage, cystoid macular edema (CME), and typical "birdshot" chorioretinal lesions. Typically, patients with birdshot chorioretinopathy are treated with systemic immunosuppressive and/or corticosteroid therapy in an effort to minimize loss of vision. Spectral-domain OCT (SD-OCT) has shown regional or generalized photoreceptor loss in addition to both retinal as well as choroidal thinning in these patients...
2016: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/27847624/prevalence-of-outer-retinal-tubulation-in-eyes-with-choroidal-neovascularization
#20
Richard Geraldo Giachetti Filho, Leandro Cabral Zacharias, Thaís Vera Monteiro, Rony Carlos Preti, Sérgio Gianoti Pimentel
BACKGROUND: Outer retinal tubulations (ORTs) are branching tubular structures located in the outer nuclear layer of the retina. The goal of this study is to determine the prevalence of ORTs observed in eyes with choroidal neovascularization (CNV) undergoing treatment with anti-angiogenic intravitreous injection (IVI) with anti-VEGF (vascular endothelial growth factor) at the Ophthalmology Department of a tertiary hospital in São Paulo, Brazil. METHODS: This is a descriptive study based on medical charts and Spectral-domain Optical Coherence Tomography (Sd-OCT) scans of 142 patients (158 eyes) treated between 2012 and 2014 with IVI of anti-VEGF for CNV...
2016: International Journal of Retina and Vitreous
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