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https://www.readbyqxmd.com/read/28547533/sensitivity-and-specificity-of-optical-coherence-tomography-angiography-oct-a-for-detection-of-choroidal-neovascularization-in-real-life-practice-and-varying-retinal-expertise-level
#1
Vaël Souedan, Eric H Souied, Violaine Caillaux, Alexandra Miere, Ala El Ameen, Rocio Blanco-Garavito
PURPOSE: To evaluate the diagnostic accuracy of OCT angiography (OCT-A) detecting or predicting choroidal neovascularization (CNV), by ophthalmologists of disparate degrees of skills in retinal diseases, using spectral domain optical coherence tomography (SD-OCT) and fluorescein angiography (FA) as a standard reference. METHODS: Retrospective observational case series. Patient presenting maculopathy and complete imaging were included. FA, SD-OCT, OCT-A and FA coupled to SD-OCT images were graded independently for presence or absence of CNV by ophthalmologists with varying expertise levels...
May 25, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28546991/structural-modeling-of-a-novel-slc38a8-mutation-that-causes-foveal-hypoplasia
#2
Marcus A Toral, Gabriel Velez, Katherine Boudreault, Kellie A Schaefer, Yu Xu, Norman Saffra, Alexander G Bassuk, Stephen H Tsang, Vinit B Mahajan
BACKGROUND: Foveal hypoplasia (FH) in the absence of albinism, aniridia, microphthalmia, or achromatopsia is exceedingly rare, and the molecular basis for the disorder remains unknown. FH is characterized by the absence of both the retinal foveal pit and avascular zone, but with preserved retinal architecture. SLC38A8 encodes a sodium-coupled neutral amino acid transporter with a preference for glutamate as a substrate. SLC38A8 has been linked to FH. Here, we describe a novel mutation to SLC38A8 which causes FH, and report the novel use of OCT-angiography to improve the precision of FH diagnosis...
May 2017: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/28546149/progression-of-lamellar-hole-associated-epiretinal-proliferation-and-retinal-changes-during-long-term-follow-up
#3
Denise Compera, Ricarda G Schumann, Matteo G Cereda, Alessandra Acquistapace, Viviane Lita, Siegfried G Priglinger, Giovanni Staurenghi, Ferdinando Bottoni
PURPOSE: To report on progression of lamellar hole-associated epiretinal proliferation (LHEP) in eyes with lamellar macular holes (LMH) using spectral-domain optical coherence tomography (SD-OCT), and to correlate with intraretinal changes and visual function. METHODS: From a retrospectively reviewed series of 167 eyes with non-full-thickness macular holes, we exclusively included a subgroup of 34 eyes with LMH and LHEP by SD-OCT evaluation. In these eyes, area of LHEP, intraretinal changes of defect diameter, central retinal thickness, defects of the ellipsoid zone and occurrence of a contractive epiretinal membrane were analysed...
May 25, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28545121/measurement-of-macular-structure-function-relationships-using-spectral-domain-optical-coherence-tomography-sd-oct-and-pattern-electroretinograms-perg
#4
Keunheung Park, Jinmi Kim, Jiwoong Lee
BACKGROUND: Retinal ganglion cell (RGC) death is a common cause of loss of vision during glaucoma. Pattern electroretinogram (PERG) is an objective measure of the central retinal function that correlates with macular GCL thickness. The aim of this study is to determine possible relationships between the N95 amplitude of pattern electroretinogram (PERGamp) and macular ganglion cell/inner plexiform layer thickness (GCIPLT). METHODS AND FINDINGS: This was a retrospective and comparative study including 74 glaucoma patients (44 early stage and 30 advanced stage cases) and 66 normal control subjects...
2017: PloS One
https://www.readbyqxmd.com/read/28538978/the-characteristics-of-deep-optic-nerve-head-morphology-in-myopic-normal-tension-glaucoma
#5
Jong Chul Han, Eun Jung Lee, Si Bum Kim, Changwon Kee
Purpose: To investigate the relationship between axial length (AL) and deep optic nerve head (ONH) structure and to evaluate the characteristics of deep ONH structures in myopic normal tension glaucoma (NTG). Methods: The following parameters were assessed using spectral-domain optical coherence tomography (SD-OCT): externally oblique border tissue (EOBT) length, ONH tilt angle, optic canal (OC) obliqueness, and β-zone peripapillary atrophy (PPA). In addition, the angular location of the maximal value of each parameter and retinal nerve fiber layer (RNFL) defect were measured using infrared and red-free photos...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28535994/diabetic-choroidopathy
#6
Gerard A Lutty
Early histopathological studies of diabetic choroids demonstrated loss of choriocapillaris (CC), tortuous blood vessels, microaneurysms, drusenoid deposits on Bruchs membrane, and choroidal neovascularization. The preponderance of histopathological changes were at and beyond equator. Studies from my lab suggest that diabetic choroidopathy is an inflammatory disease in that leukocyte adhesion molecules are elevated in the choroidal vasculature and polymorphonuclear neutrophils are often associated with sites of vascular loss...
May 20, 2017: Vision Research
https://www.readbyqxmd.com/read/28535756/switch-to-aflibercept-or-ranibizumab-after-initial-treatment-with-bevacizumab-in-eyes-with-neovascular-amd
#7
Maria Waizel, Margarita G Todorova, Michael Masyk, Katharina Wolf, Annekatrin Rickmann, Khaled Helaiwa, Björn R Blanke, Peter Szurman
BACKGROUND: To evaluate changes in central macular thickness (CMT) and visual outcome in patients with neovascular age-related macular degeneration (AMD) treated initially with bevacizumab and subsequently switched to either aflibercept or ranibizumab. METHODS: Observational clinical study was performed. We measured the structural outcome (CMT on SD-OCT; μm) and the visual outcome (best corrected visual acuity (BCVA); logMAR), as follows: before treatment (at baseline), following bevacizumab treatment (switch follow-up) and after switching from bevacizumab to aflibercept- or ranibizumab treatment (final follow-up, AG/, RG)...
May 23, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28534244/proposal-of-a-simple-optical-coherence-tomography-based-scoring-system-for-progression-of-age-related-macular-degeneration
#8
Jianqin Lei, Siva Balasubramanian, Nizar Saleh Abdelfattah, Muneeswar G Nittala, SriniVas R Sadda
PURPOSE: To develop a simple, clinically practical, optical coherence tomography (OCT)-based scoring system for early age-related macular degeneration (AMD) to prognosticate risk for progression to late AMD. METHODS: We retrospectively reviewed OCT images (512 × 128 macular cube, Cirrus) from 138 patients diagnosed of early AMD in at least one eye and follow-up of at least 12 months. For patients with early AMD in both eyes, only the right eye was chosen as the study eye for longitudinal assessment...
May 22, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28528295/a-machine-learning-graph-based-approach-for-3d-segmentation-of-bruch-s-membrane-opening-from-glaucomatous-sd-oct-volumes
#9
Mohammad Saleh Miri, Michael D Abràmoff, Young H Kwon, Milan Sonka, Mona K Garvin
Bruch's membrane opening-minimum rim width (BMO-MRW) is a recently proposed structural parameter which estimates the remaining nerve fiber bundles in the retina and is superior to other conventional structural parameters for diagnosing glaucoma. Measuring this structural parameter requires identification of BMO locations within spectral domain-optical coherence tomography (SD-OCT) volumes. While most automated approaches for segmentation of the BMO either segment the 2D projection of BMO points or identify BMO points in individual B-scans, in this work, we propose a machine-learning graph-based approach for true 3D segmentation of BMO from glaucomatous SD-OCT volumes...
May 6, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/28527028/leukemic-retinopathy-and-foveal-infiltrates
#10
Vinod Kumar, Devesh Kumawat, Sabin Dhakal
The authors describe leukemic retinopathy with foveal leukemic infiltrates as the presenting feature of chronic myeloid leukemia. Spectral domain optical coherence tomography (SD-OCT) features of leukemic foveal infiltrates are presented. Though the retinopathy resolved with remission of disease, visual recovery was not complete due to loss of ellipsoid zone on SD-OCT.
May 19, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28525681/unveiling-idiopathic-macular-telangiectasia-clinical-applications-of-optical-coherence-tomography-angiography
#11
Marco A Gonzalez, Diana Shechtman, Jay M Haynie, Leo Semes
PURPOSE: Idiopathic macular telangiectasia type 2 (IMT2) is a bilateral acquired maculopathy, with a spectrum of clinical presentations associated with inner retinal telangiectatic vascular anomalies. Cases often are underdiagnosed or misdiagnosed. Current diagnostic modalities such as spectral-domain optical coherence tomography (SD-OCT) and fluorescein angiography (FA) are valuable to the understanding of the clinicopathology. More recently, optical coherence tomography angiography (OCTA), as an emerging noninvasive technology, has been shown to be particularly useful in the assessment and management of IMT2...
May 19, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28524105/structural-analysis-of-polymer-composites-using-spectral-domain-optical-coherence-tomography
#12
Muhammad Faizan Shirazi, Mansik Jeon, Jeehyun Kim
The structural analysis of nylon/graphene oxide (NY/GO) and polyetherblockamide/ trisilinolphenyl-polyhederal oligomeric silsesquioxane (PEBA/t-POSS) composites were performed using high-resolution spectral domain optical coherence tomography (SD-OCT). This optical technology revealed both cross-sectional, as well as sub-layer depth information of sample. The non-destructive real-time imaging demonstrated the nature of defects in the composites. The thickness and location of each defect point in the composites were measured using A-scan analysis on the SD-OCT images...
May 18, 2017: Sensors
https://www.readbyqxmd.com/read/28520639/wrinkled-vascularized-retinal-pigment-epithelium-detachment-prognosis-after-intravitreal-anti-vegf-therapy
#13
Delphine Lam, Oudy Semoun, Rocio Blanco-Garavito, Camille Jung, Diem T Nguyen, Eric H Souied, Gerard Mimoun
BACKGROUND/PURPOSE: Neovascular age-related macular degeneration (nAMD) is frequently associated with vascularized pigment epithelial detachment (v-PED). We observed a peculiar characteristic of v-PED characterized by small lacy folds of the retinal pigment epithelium, appearing as a wrinkled PED (w-PED) on spectral domain optical coherence tomography (SD-OCT). Our purpose was to describe the visual prognosis and number of intravitreal injections in w-PED compared with non-w-PED. METHODS: In this retrospective, case-control series, we reviewed retrospectively medical records of 52 eyes of 51 patients who were consecutively included between November 1 and 30, 2015 with a previous minimum 3-year follow-up...
May 16, 2017: Retina
https://www.readbyqxmd.com/read/28511578/retinal-atrophy-in-relation-to-visual-functioning-and-vision-related-quality-of-life-in-patients-with-multiple-sclerosis
#14
Lisanne J Balk, Danko Coric, Jenny A Nij Bijvank, Joep Killestein, Bernard Mj Uitdehaag, Axel Petzold
BACKGROUND: Inner retinal layer atrophy in patients with multiple sclerosis (MS) has been validated as a structural imaging biomarker for neurodegeneration. OBJECTIVE: To determine how retinal layer thickness relates to high-contrast visual acuity (HCVA), low-contrast visual acuity (LCVA) and vision-related quality of life (QoL) and to investigate the effect of previous episodes on MS-associated optic neuritis (MSON). METHODS: Spectral-domain optical coherence tomography (SD-OCT) was performed in 267 patients with MS...
May 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28508380/-optical-coherence-tomography-in-eyes-with-senile-retinoschisis-sd-oct-versus-ultrasound-examinations-and-assessment-of-the-vitreoretinal-interface
#15
A Bringewatt, S Burzer, N Feucht, M Maier
BACKGROUND: In addition to ocular ultrasonography (US), spectral domain optical coherence tomography (SD-OCT) is available in order to diagnose senile retinoschisis (sRS). SD-OCT also allows for classification of posterior vitreous detachment (PVD) in healthy eyes. OBJECTIVES: Reevaluation of the value and additional benefit of both imaging procedures. SD-OCT-based evaluation of PVD stages in sRS patients. MATERIALS AND METHODS: Diagnostic results of 33 eyes in 26 patients with clinical suspicion of sRS were retrospectively analysed...
May 15, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/28507532/spectral-domain-optical-coherence-tomography-as-a-new-diagnostic-marker-for-idiopathic-normal-pressure-hydrocephalus
#16
Joana M Afonso, Manuel Falcão, Frank Schlichtenbrede, Fernando Falcão-Reis, Sérgio Estrela Silva, Till M Schneider
PURPOSE: Characterized by a progressive onset of gait disturbances, dementia, and urinary incontinence, idiopathic normal pressure hydrocephalus (iNPH) is considered a rare, but under-diagnosed disease. Non-invasive diagnostic markers are still insufficient to enable the diagnosis of iNPH with certainty and yet early treatment with ventriculoperitoneal (VP) shunting can reverse symptoms and stop disease progression. Vascular circulation abnormalities in iNPH may be reflected by changes in subfoveal and peripapillary choroidal thickness (PPChT)...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28505617/ganglion-cell-complex-in-early-and-intermediate-age-related-macular-degeneration-evidence-by-sd-oct-manual-segmentation
#17
Pedro Camacho, Marco Dutra-Medeiros, Liliana Páris
PURPOSE: To evaluate ganglion cell layer (GCL) and ganglion cell complex (GCC) thickness manually by spectral-domain optical coherence tomography in subjects with early and intermediate age-related macular degeneration (AMD) in 12 locations on the horizontal meridian. METHODS: A total of 450 eyes (specifically, 246 eyes classified as having early/intermediate AMD plus 204 control eyes) were studied. Mann-Whitney U and Kruskal-Wallis tests were used to compare values between the healthy controls and the AMD group and also between the subgroups under study...
May 16, 2017: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/28503435/evaluation-of-hyperreflective-foci-as-a-prognostic-factor-of-visual-outcome-in-retinal-vein-occlusion
#18
Bin Mo, Hai-Ying Zhou, Xuan Jiao, Feng Zhang
AIM: To evaluate the potential role of hyperreflective foci (HF) as a prognostic indicator of visual outcome in patients with macular edema (ME) due to retinal vein occlusion (RVO). METHODS: We retrospectively reviewed 50 eyes of 50 patients with ME due to ischemic central retinal vein occlusion (CRVO), non-ischemic CRVO and branch retinal vein occlusion (BRVO) who were treated with anti-vascular endothelial growth factor (anti-VEGF) at Beijing Tongren Eye Center from January 2013 to July 2016...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28499706/pseudophakic-macular-edema-in-primary-open-angle-glaucoma-a-prospective-study-using-spectral-domain-optical-coherence-tomography
#19
Kyoung Min Lee, Eun Ji Lee, Tae-Woo Kim, Hyunjoong Kim
PURPOSE: To determine the incidence of and risk factors for pseudophakic macular edema (PME) after uncomplicated cataract surgery in primary open-angle glaucoma (POAG) using spectral-domain optical coherence tomography (SD-OCT). DESIGN: Cohort study METHODS: Macular retinal thickness was evaluated using SD-OCT at 1-week before surgery and at 1-, 3-, 6-, and 12-months postoperatively, in 70 POAG and 68 control eyes. Forty-three healthy subjects without impaired vision or cystoid PME were recruited separately as pilot samples to define significant PME...
May 10, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28499705/measurement-and-reproducibility-of-preserved-ellipsoid-zone-area-and-preserved-rpe-area-in-a-cohort-of-eyes-with-choroideremia
#20
Amir H Hariri, Swetha B Velaga, Aniz Girach, Michael S Ip, Phuc V Le, Byron L Lam, M Dominik Fischer, Eeva-Marja Sankila, Mark Pennesi, Frank G Holz, Robert E MacLaren, David G Birch, Carel B Hoyng, Ian M MacDonald, Graeme C Black, Stephen H Tsang, Neil M Bressler, Michael Larsen, Michael B Gorin, Andrew R Webster, SriniVas R Sadda
PURPOSE: To identify valid and reproducible methods for quantifying anatomical outcome measures for eyes with choroideremia (CHM) in clinical trials. DESIGN: Reliability analysis study. METHODS: In this multicenter study, patients with confirmed genetic diagnosis of CHM were enrolled. All cases underwent spectral domain optical coherence tomography (SD-OCT) and fundus autofluorescence (FAF) imaging. Two graders independently delineated boundaries of preserved autofluorescence (PAF) and preserved ellipsoid zone (EZ) on FAF and OCT images respectively...
May 9, 2017: American Journal of Ophthalmology
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