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Oncofertility

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https://www.readbyqxmd.com/read/28408620/oncofertility-fertile-ground-for-conflict-between-patient-autonomy-and-medical-values
#1
Sarah K Walsh, Elizabeth S Ginsburg, Lisa Soleymani Lehmann, Ann H Partridge
Oncofertility is a unique, multidisciplinary field that serves to bridge the gap between available fertility resources and the special reproductive needs of cancer patients. Oncofertility is a growing field due to the increasing number of survivors, development of new oncologic therapies, extension of duration of therapies, and development and refinement of reproductive therapies. While the technologies and demand for services expand, clinicians need to be appropriately prepared for dealing with various clinical scenarios that may require ethical deliberation...
April 13, 2017: Oncologist
https://www.readbyqxmd.com/read/28333032/ethical-moral-and-other-aspects-related-to-fertility-preservation-in-cancer-patients
#2
Bruno Ramalho de Carvalho, Jhenifer Kliemchen, Teresa K Woodruff
Post-treatment fertility emerges as an important issue in the early counseling of individuals with cancer, since survivors may have their quality of life affected by the occurrence of functional failure of the gonads because of antineoplastic therapies. In the context, oncofertility has been developed as an interdisciplinary field of study that combines expertise in reproductive medicine and oncology, to provide strategies aiming to maintain the possibility of future procreation. Today, we have many options and techniques available for the preservation of gametes in men and women...
February 1, 2017: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/28265333/fertility-preservation-options-for-children-and-adolescents-with-cancer
#3
REVIEW
Rodrigo L P Romao, Armando J Lorenzo
INTRODUCTION: Cancer in children and adolescents has seen a stark rise in survival rates in the last decades; overall survival in excess of 80% can be reasonably expected for many newly diagnosed patients with malignancies in this age group. Survivorship has unfolded several specific issues faced by these patients, including fertility concerns. Hence, fertility preservation efforts have been discussed and undertaken with increased frequency. METHODS: In this article, the authors provide a broad overview of the current recommendations surrounding fertility preservation in this patient population...
January 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28222080/patient-inspired-research-a-better-way-to-go
#4
(no author information available yet)
Recently, I attended a meeting of the Oncofertility Consortium and had one of those "a-ha" moments that change one's perspective in a very real way. A surgeon from Sweden was talking about uterus transplantations, and she described how these came about. She told a story about one of her colleagues, who was talking to a young woman who had cervical cancer and had a hysterectomy. The patient asked the physician if they could give her a "new" uterus so that one day she could have a biological child. The physician told her that was not possible and the patient responded, "Why not?" That prompted the physician to start a new field of research, uterine transplantation, that has had some early successes, as well as many failures...
March 1, 2017: Oncology Nursing Forum
https://www.readbyqxmd.com/read/28221816/priorities-in-fertility-decisions-for-reproductive-aged-cancer-patients-fertility-attitudes-and-cancer-treatment-study
#5
Dina M Flink, Laxmi A Kondapalli, Yvonne Kellar-Guenther
PURPOSE: The Fertility Attitudes and Cancer Treatment Study (FACTS) aims at better understanding the reasons and priorities of young adult cancer patients making decisions for fertility preservation (FP). Identifying the factors that center around a patient's fertility decisions will support the development of educational tools for providers and improve clinical care to meet patients' reproductive needs. METHODS: An exploratory qualitative study was conducted of 27 newly diagnosed male and female cancer patients who had presented for an oncofertility consultation...
February 21, 2017: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/28207285/improvements-in-clinical-trials-information-will-improve-the-reproductive-health-and-fertility-of-cancer-patients
#6
Angela Dauti, Brigitte Gerstl, Serena Chong, Orin Chisholm, Antoinette Anazodo
There are a number of barriers that result in cancer patients not being referred for oncofertility care, which include knowledge about reproductive risks of antineoplastic agents. Without this information, clinicians do not always make recommendations for oncofertility care. The objective of this study was to describe the level of reproductive information and recommendations that clinicians have available in clinical trial protocols regarding oncofertility management and follow-up, and the information that patients may receive in clinical trials patient information sheets or consent forms...
February 16, 2017: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/28012689/oncofertility-for-women-with-gynecologic-malignancies
#7
REVIEW
Jessica L Chan, Erica T Wang
The emerging field of oncofertility addresses fertility and the reproductive health needs for cancer patients, a key topic in cancer survivorship. Given that the standard treatment for gynecologic malignancies involves removal of reproductive organs, pelvic radiation, or chemotherapy, the effect of such treatment on fertility and options for fertility preservation are even more relevant than for other malignancies. In young women with new diagnoses of cervical, endometrial, or ovarian cancers, viable strategies for fertility preservation without compromising oncological outcome exist and should be considered...
March 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28009430/timing-should-no-longer-be-an-obstacle-to-oocyte-cryopreservation-in-patients-with-cancer
#8
Giorgia Mangili, Enrico Papaleo, Cristina Sigismondi, Rossella Masciangelo, Veronica Sarais, Veronica Giorgione, Roberta Nale, Laura Privitera, Letizia Carnelli, Valentina Di Mattei, Massimo Candiani
PURPOSE: Anticancer treatment-related infertility is preventable with oocyte cryopreservation, but this is often not considered a relevant issue, due to lack of knowledge and time. The aim of this study is to prove that adequate organization of an Oncofertility Unit and the use of new protocols for controlled ovarian stimulation (COS) can reduce the time required by the procedure, encouraging consultants and patients to preserve fertility before gonadotoxic treatments. METHODS: A total of 125 patients diagnosed with malignant tumors were referred to the Oncofertility Unit of San Raffaele Hospital: 52 patients between April 2011 and October 2013 and 73 patients between October 2013 and November 2015...
March 24, 2017: Tumori
https://www.readbyqxmd.com/read/27966219/oncofertility-program-implementation-increases-access-to-fertility-preservation-options-and-assisted-reproductive-procedures-for-breast-cancer-patients
#9
Joceline V Vu, Natalia C Llarena, Samantha L Estevez, Molly B Moravek, Jacqueline S Jeruss
BACKGROUND AND OBJECTIVES: Breast cancer treatment can cause premature ovarian failure, yet the majority of young cancer patients do not receive adequate education about treatment effects before initiating chemotherapy. We studied the impact of an oncofertility program on access to fertility preservation. METHODS: An oncofertility program was initiated to foster collaboration between oncologists and reproductive endocrinologists, and to help increase access to fertility preservation...
February 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27918727/the-current-state-of-reproductive-biology-research-in-australia-and-new-zealand-core-themes-from-the-society-for-reproductive-biology-annual-meeting-2016
#10
L K Akison, P H Andraweera, M J Bertoldo, H M Brown, J S M Cuffe, T Fullston, O Holland, J E Schjenken
Because reproduction is essential for all life, it is central to our understanding of all aspects of biology. The Society for Reproductive Biology (SRB) 2016 conference held on the Gold Coast (Qld, Australia) displayed the current breadth of reproductive research in Australia and New Zealand, with additional insights from world leaders in the field. This conference review provides a focused summary of the key questions, emerging ideas and novel technologies that were presented in the symposia. Presented research demonstrated key advances in how stem cell biology may allow us to better understand pluripotency, as well as how environmental and lifestyle factors, such as circadian disruption, smoking, alcohol and diet, affect gametogenesis, embryo implantation, placental function and reproductive capacity...
December 6, 2016: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/27900615/good-manufacturing-practice-requirements-for-the-production-of-tissue-vitrification-and-warming-and-recovery-kits-for-clinical-research
#11
Monica M Laronda, Kelly E McKinnon, Alison Y Ting, Ann V Le Fever, Mary B Zelinski, Teresa K Woodruff
Products that are manufactured for use in a clinical trial, with the intent of gaining US Food and Drug Administration (FDA) approval for clinical use, must be produced under an FDA approved investigational new drug (IND) application. We describe work done toward generating reliable methodology and materials for preserving ovarian cortical tissue through a vitrification kit and reviving this tissue through a warming and recovery kit. We have described the critical steps, procedures, and environments for manufacturing products with the intent of submitting an IND...
February 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/27879541/ethical-barriers-in-adolescent-oncofertility-counseling
#12
Daniel V Runco, Julia F Taylor, Paul R Helft
Adult survivors of pediatric cancers are at substantial risk for infertility. Oncofertility is an emerging field in medicine that has focused on the fertility preservation of these patients. As the field continues to develop, there are several areas in which our practice has improved. However, several ethical concerns still exist involving beneficence, nonmaleficence, informed consent, adolescent assent, and posthumous use of reproductive tissues. Because the field is still developing, great disparities exist in available options depending on age, ability to pay, and geographic location...
January 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/27837562/mature-oocyte-cryopreservation-for-fertility-preservation
#13
Tina Liang, Tarek Motan
In recent decades, advances in cancer treatment have led to a dramatic improvement in long term survival. This has led to an increasing focus on quality of life after surviving cancer treatment, with fertility being an important aspect. Given the known reproductive risks of cancer therapies, there has been a growing interest in the field of fertility preservation (also referred to as oncofertility). Mature oocyte cryopreservation is no longer considered experimental and has become a realistic option for reproductive aged women prior to undergoing cancer treatment...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27803586/the-role-of-indian-gynecologists-in-oncofertility-care-and-counselling
#14
Nalini Mahajan, Madhuri Patil, Surleen Kaur, Simrandeep Kaur, Padmaja Naidu
Oncofertility is gaining importance because of increasing cancer incidence, high survivorship, the need to provide a good quality of life to survivors and the desire of patients to preserve their fertility. Disseminating information about the effect of cancer and cancer treatment on fertility and the availability and effectiveness of fertility preservation techniques is critical. Gynaecologists in India act as family physicians and are in a unique position to guide cancer patients on issues of fertility and fertility preservation...
July 2016: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/27763800/the-utility-of-decision-trees-in-oncofertility-care-in-japan
#15
Yuki Ito, Eriko Shiraishi, Atsuko Kato, Takayuki Haino, Kouhei Sugimoto, Aikou Okamoto, Nao Suzuki
PURPOSE: To identify the utility and issues associated with the use of decision trees in oncofertility patient care in Japan. METHODS: A total of 35 women who had been diagnosed with cancer, but had not begun anticancer treatment, were enrolled. We applied the oncofertility decision tree for women published by Gardino et al. to counsel a consecutive series of women on fertility preservation (FP) options following cancer diagnosis. Percentage of women who decided to undergo oocyte retrieval for embryo cryopreservation and the expected live-birth rate for these patients were calculated using the following equation: expected live-birth rate = pregnancy rate at each age per embryo transfer × (1 - miscarriage rate) × No...
March 2017: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/27614150/laparoscopic-ovarian-transposition-before-pelvic-cancer-treatment-ovarian-function-and-fertility-preservation
#16
REVIEW
Nash S Moawad, Estefania Santamaria, Alice Rhoton-Vlasak, Judith L Lightsey
Survivors of pelvic cancer treatment live with the ramifications of pelvic radiation for many years after their cure. Several options are available to preserve ovarian function and fertility in reproductive age women undergoing pelvic radiation. Laparoscopic ovarian transposition is an under-utilized, yet fairly simple surgical procedure to relocate the ovaries away from the radiation field. Although randomized-controlled trials on the outcomes of ovarian transposition are scarce, there is a growing body of evidence on the risks and benefits of this procedure, in terms of prevention of premature ovarian failure, and potentially preserving fertility...
January 1, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27543212/oncofertility-considerations-in-adolescents-and-young-adults-given-a-diagnosis-of-melanoma-fertility-risk-of-food-and-drug-administration-approved-systemic-therapies
#17
Jessica R Walter, Shuai Xu, Amy S Paller, Jennifer N Choi, Teresa K Woodruff
BACKGROUND: Melanoma is the most common cancer diagnosed for patients ages 25 to 29 years, the group with the highest birth rates in the United States. Oncofertility is a new field addressing the reproductive needs of patients with cancer facing fertility-threatening treatments. OBJECTIVE: We sought to assess gender-specific fertility risk for Food and Drug Administration (FDA)-approved melanoma therapies with a new risk category system. METHODS: We conducted a retrospective review of FDA, European Union, and Health Canada regulatory filings, along with previously published reports to grade fertility risk of systemic melanoma therapies...
September 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27531055/oncofertility-in-japan-advances-in-research-and-the-roles-of-oncofertility-consortia
#18
Nao Suzuki
In Japan, an important issue is to be able to provide young cancer patients with timely and accurate information about the indications and options for fertility preservation when it is applicable. Therefore, it is necessary to create an environment that assists young cancer patients to make a decision about whether or not to choose fertility preservation. The Japan Society for Fertility Preservation was established in 2012, as Japan's first oncofertility association. Its purpose is to create an environment in which cancer patients can receive evidence-based oncofertility care...
October 2016: Future Oncology
https://www.readbyqxmd.com/read/27431414/oncofertility-knowledge-attitudes-and-practices-of-canadian-breast-surgeons
#19
Ellen Warner, Samantha Yee, Erin Kennedy, Karen Glass, Shu Foong, Maureen Seminsky, May Lynn Quan
BACKGROUND: Guidelines recommend that oncologists discuss treatment-related fertility issues with young cancer patients as early as possible after diagnosis and, if appropriate, expedite referral for fertility preservation (FP). This study sought to determine the attitudes and practices of Canadian breast surgeons regarding fertility issues, as well as barriers to and facilitators of fertility discussion and referrals. METHODS: Semistructured telephone interviews were conducted with 28 site lead surgeons (SLSs) at 28 (97 %) of 29 centers (25 % cancer centers, 64 % teaching hospitals) across Canada participating in RUBY, a pan-Canadian research program for young women with breast cancer...
July 18, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27402102/a-survey-on-fertility-management-in-young-women-of-reproductive-age-treated-with-chemotherapy
#20
Akiko Abe, Akira Kuwahara, Takeshi Iwasa, Masato Nishimura, Minoru Irahara
BACKGROUND: Treatment-related infertility is an important issue for cancer survivors of reproductive age. We aimed to determine the understanding and management of fertility issues in cancer survivors by health care providers. METHODS: We studied 112 patients aged 15-40 years who underwent chemotherapy in Tokushima University Hospital. The gynecologists and oncologists who treated these patients were surveyed regarding their concerns about infertility issues in young cancer survivors...
December 2016: International Journal of Clinical Oncology
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