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Monica M Laronda, Kelly E McKinnon, Alison Y Ting, Ann V Le Fever, Mary B Zelinski, Teresa K Woodruff
Products that are manufactured for use in a clinical trial, with the intent of gaining US Food and Drug Administration (FDA) approval for clinical use, must be produced under an FDA approved investigational new drug (IND) application. We describe work done toward generating reliable methodology and materials for preserving ovarian cortical tissue through a vitrification kit and reviving this tissue through a warming and recovery kit. We have described the critical steps, procedures, and environments for manufacturing products with the intent of submitting an IND...
November 30, 2016: Journal of Assisted Reproduction and Genetics
Daniel V Runco, Julia F Taylor, Paul R Helft
Adult survivors of pediatric cancers are at substantial risk for infertility. Oncofertility is an emerging field in medicine that has focused on the fertility preservation of these patients. As the field continues to develop, there are several areas in which our practice has improved. However, several ethical concerns still exist involving beneficence, nonmaleficence, informed consent, adolescent assent, and posthumous use of reproductive tissues. Because the field is still developing, great disparities exist in available options depending on age, ability to pay, and geographic location...
November 22, 2016: Journal of Pediatric Hematology/oncology
Tina Liang, Tarek Motan
In recent decades, advances in cancer treatment have led to a dramatic improvement in long term survival. This has led to an increasing focus on quality of life after surviving cancer treatment, with fertility being an important aspect. Given the known reproductive risks of cancer therapies, there has been a growing interest in the field of fertility preservation (also referred to as oncofertility). Mature oocyte cryopreservation is no longer considered experimental and has become a realistic option for reproductive aged women prior to undergoing cancer treatment...
2016: Advances in Experimental Medicine and Biology
Nalini Mahajan, Madhuri Patil, Surleen Kaur, Simrandeep Kaur, Padmaja Naidu
Oncofertility is gaining importance because of increasing cancer incidence, high survivorship, the need to provide a good quality of life to survivors and the desire of patients to preserve their fertility. Disseminating information about the effect of cancer and cancer treatment on fertility and the availability and effectiveness of fertility preservation techniques is critical. Gynaecologists in India act as family physicians and are in a unique position to guide cancer patients on issues of fertility and fertility preservation...
July 2016: Journal of Human Reproductive Sciences
Yuki Ito, Eriko Shiraishi, Atsuko Kato, Takayuki Haino, Kouhei Sugimoto, Aikou Okamoto, Nao Suzuki
PURPOSE: To identify the utility and issues associated with the use of decision trees in oncofertility patient care in Japan. METHODS: A total of 35 women who had been diagnosed with cancer, but had not begun anticancer treatment, were enrolled. We applied the oncofertility decision tree for women published by Gardino et al. to counsel a consecutive series of women on fertility preservation (FP) options following cancer diagnosis. Percentage of women who decided to undergo oocyte retrieval for embryo cryopreservation and the expected live-birth rate for these patients were calculated using the following equation: expected live-birth rate = pregnancy rate at each age per embryo transfer × (1 - miscarriage rate) × No...
October 20, 2016: Journal of Adolescent and Young Adult Oncology
Nash S Moawad, Estefania Santamaria, Alice Rhoton-Vlasak, Judith L Lightsey
Survivors of pelvic cancer treatment live with the ramifications of pelvic radiation for many years after their cure. Several options are available to preserve ovarian function and fertility in reproductive age women undergoing pelvic radiation. Laparoscopic ovarian transposition is an under-utilized, yet fairly simple surgical procedure to relocate the ovaries away from the radiation field. Although randomized-controlled trials on the outcomes of ovarian transposition are scarce, there is a growing body of evidence on the risks and benefits of this procedure, in terms of prevention of premature ovarian failure, and potentially preserving fertility...
September 8, 2016: Journal of Minimally Invasive Gynecology
Jessica R Walter, Shuai Xu, Amy S Paller, Jennifer N Choi, Teresa K Woodruff
BACKGROUND: Melanoma is the most common cancer diagnosed for patients ages 25 to 29 years, the group with the highest birth rates in the United States. Oncofertility is a new field addressing the reproductive needs of patients with cancer facing fertility-threatening treatments. OBJECTIVE: We sought to assess gender-specific fertility risk for Food and Drug Administration (FDA)-approved melanoma therapies with a new risk category system. METHODS: We conducted a retrospective review of FDA, European Union, and Health Canada regulatory filings, along with previously published reports to grade fertility risk of systemic melanoma therapies...
September 2016: Journal of the American Academy of Dermatology
Nao Suzuki
In Japan, an important issue is to be able to provide young cancer patients with timely and accurate information about the indications and options for fertility preservation when it is applicable. Therefore, it is necessary to create an environment that assists young cancer patients to make a decision about whether or not to choose fertility preservation. The Japan Society for Fertility Preservation was established in 2012, as Japan's first oncofertility association. Its purpose is to create an environment in which cancer patients can receive evidence-based oncofertility care...
October 2016: Future Oncology
Ellen Warner, Samantha Yee, Erin Kennedy, Karen Glass, Shu Foong, Maureen Seminsky, May Lynn Quan
BACKGROUND: Guidelines recommend that oncologists discuss treatment-related fertility issues with young cancer patients as early as possible after diagnosis and, if appropriate, expedite referral for fertility preservation (FP). This study sought to determine the attitudes and practices of Canadian breast surgeons regarding fertility issues, as well as barriers to and facilitators of fertility discussion and referrals. METHODS: Semistructured telephone interviews were conducted with 28 site lead surgeons (SLSs) at 28 (97 %) of 29 centers (25 % cancer centers, 64 % teaching hospitals) across Canada participating in RUBY, a pan-Canadian research program for young women with breast cancer...
July 18, 2016: Annals of Surgical Oncology
Akiko Abe, Akira Kuwahara, Takeshi Iwasa, Masato Nishimura, Minoru Irahara
BACKGROUND: Treatment-related infertility is an important issue for cancer survivors of reproductive age. We aimed to determine the understanding and management of fertility issues in cancer survivors by health care providers. METHODS: We studied 112 patients aged 15-40 years who underwent chemotherapy in Tokushima University Hospital. The gynecologists and oncologists who treated these patients were surveyed regarding their concerns about infertility issues in young cancer survivors...
December 2016: International Journal of Clinical Oncology
Megan Castle, Charlotte Cleveland, Diana Gordon, Lynda Jones, Mary Zelinski, Patricia Winter, Jeffrey Chang, Ericka Senegar-Mitchell, Christos Coutifaris, Jamie Shuda, Monica Mainigi, Marisa Bartolomei, Teresa K Woodruff
The lack of a national reproductive biology curriculum leads to critical knowledge gaps in today's high school students' comprehensive understanding of human biology. The Oncofertility Consortium developed curricula that address the basic and clinical aspects of reproductive biology. Launching this academy and creating easy-to-disseminate learning modules allowed other universities to implement similar programs across the country. The expansion of this informal, extracurricular academy on reproductive health from Northwestern University to the University of California, San Diego, Oregon Health & Science University, and the University of Pennsylvania magnifies the scope of scientific learning to students who might not otherwise be exposed to this important information...
July 2016: Biology of Reproduction
Miyuki Harada, Yutaka Osuga
An improvement in the survival rates of cancer patients and recent advancements in assisted reproductive technologies have led to remarkable progress in oncofertility and fertility preservation treatments. Although there are several available or emerging approaches for fertility preservation, the limited evidence for each strategy is the greatest concern. In this review, we discuss the concerns on currently available options, and propose new approaches for fertility preservation that may be available in the future...
October 2016: Future Oncology
Alexander Tuan Falk, Cyrus Chargari, Jean-Michel Hannoun-Lévi, Caroline Adrados, Julie Antomarchi, Jean-Baptiste Guy, Renaud Mazeron, Christine Haie-Meder, Nicolas Magné
Fertility is a major part of the global care of patients treated for cancer. A new discipline known as oncofertility has emerged in some countries. Although the relationship between chemotherapy and external radiotherapy and fertility has been studied and reported, there is only scarce data available on brachytherapy. This systematic review aims to report available knowledge on the impact of brachytherapy on fertility. Specific consultations should be considered before brachytherapy to inform patients about their fertility preservation options...
June 2016: Human Fertility: Journal of the British Fertility Society
Lauren M Ataman, Jhenifer K Rodrigues, Ricardo M Marinho, João P J Caetano, Maurício B Chehin, Eduardo L Alves da Motta, Paulo Serafini, Nao Suzuki, Tatsuro Furui, Seido Takae, Yodo Sugishita, Ken-Ichiro Morishige, Teresa Almeida-Santos, Cláudia Melo, Karen Buzaglo, Kate Irwin, W Hamish Wallace, Richard A Anderson, Roderick T Mitchell, Evelyn E Telfer, Satish K Adiga, Antoinette Anazodo, Catharyn Stern, Elizabeth Sullivan, Yasmin Jayasinghe, Lisa Orme, Richard Cohn, Rob McLachlan, Rebecca Deans, Franca Agresta, Brigitte Gerstl, William L Ledger, Rebecca L Robker, João M de Meneses E Silva, Lígia H F Melo E Silva, Franciele O Lunardi, Jung R Lee, Chang S Suh, Michael De Vos, Ellen Van Moer, Dominic Stoop, Veerle Vloeberghs, Johan Smitz, Herman Tournaye, Ludwig Wildt, Katharina Winkler-Crepaz, Claus Y Andersen, Brigid M Smith, Kristin Smith, Teresa K Woodruff
Fertility preservation in the cancer setting, known as oncofertility, is a field that requires cross-disciplinary interaction between physicians, basic scientists, clinical researchers, ethicists, lawyers, educators, and religious leaders. Funded by the National Institutes of Health, the Oncofertility Consortium (OC) was formed to be a scientifically grounded, transparent, and altruistic resource, both intellectual and monetary, for building this new field of practice capable of addressing the unique needs of young patients with cancer...
April 2016: Journal of Global Oncology
Clarisa R Gracia, Teresa Woodruff
No abstract text is available yet for this article.
May 1, 2016: JAMA Oncology
Deepa Bhartiya
No abstract text is available yet for this article.
May 1, 2016: JAMA Oncology
Dana Marie Roque, Alessandro D Santin
No abstract text is available yet for this article.
July 2016: Future Oncology
Antoinette C Anazodo, Catharyn J Stern, Robert I McLachlan, Brigitte Gerstl, Franca Agresta, Richard J Cohn, Yasmin Jayasinghe, Claire E Wakefield, Genevieve Daly, Daisy Chan, Lorrae Gilbert, Matthew Kemertzis, Lisa M Orme, Handan Wand, Rosalie Viney, Lynn Gillam, Rebecca Deans, Murali Jetti, John Wu, Michael Chapman, William Ledger, Elizabeth A Sullivan
Improvements in cancer diagnosis and treatment in patients of a reproductive age have led to significant improvements in survival rates; however, a patient's fertility can be affected by both cancer and its treatment. As survival rates improve, there is an expectation by clinicians and patients that patient's reproductive potential should be considered and protected as much as possible. However, there is a lack of data about current fertility preservation (FP) uptake as well as accurate data on the acute or permanent reproductive risks of cancer treatment, complications of FP in cancer patients, and the use and success of assisted reproductive technology by cancer survivors...
September 2016: Journal of Adolescent and Young Adult Oncology
Antoinette C Anazodo, Brigitte Gerstl, Catharyn J Stern, Robert I McLachlan, Franca Agresta, Yasmin Jayasinghe, Richard J Cohn, Claire E Wakefield, Michael Chapman, William Ledger, Elizabeth A Sullivan
PURPOSE: In Australia and New Zealand, there has not been a national systematic development of oncofertility services for cancer patients of reproductive age although many cancer and fertility centers have independently developed services. A number of barriers exist to the development of these services, including a lack of clear referral pathways, a lack of communication between clinicians and patients about fertility preservation, differences in the knowledge base of clinicians about the risk of cancer treatment causing infertility and fertility preservation options, a lack of national health insurance funding covering all aspects of fertility preservation, and storage costs and cultural, religious, and ethical barriers...
September 2016: Journal of Adolescent and Young Adult Oncology
Gwendolyn P Quinn, Teresa K Woodruff, Caprice A Knapp, Meghan Lorraine Bowman, Joyce Reinecke, Susan T Vadaparampil
As cancer survivors live longer, fertility and reproductive health become important health concerns. Like other secondary effects of cancer treatment, these anticipated health risks should be addressed before the initiation of cancer treatment. While existing and emerging technologies may prevent or reduce risk of infertility (e.g., sperm, oocyte, embryo, or tissue banking), the lack of a trained workforce knowledgeable about oncology and reproductive health poses a barrier to care. The allied health professional (AHP) is a target of opportunity because of the direct and sustained patient relationships...
September 2016: Journal of Adolescent and Young Adult Oncology
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