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https://www.readbyqxmd.com/read/29457936/prevalence-structure-and-distribution-of-novel-parasite-cysts-containing-dracunculus-species-in-river-otters-lontra-canadensis-from-arkansas
#1
Renn Tumlison, Allison Surf
Adult female Guinea worms (Dracunculus spp.) usually are reported to occur singly in the extremities of their hosts, from which they deliver their larvae through fistulae in the host's skin into the water. We visually examined for presence of worms in the fascia of the limbs of skinned carcasses of 184 river otters (Lontra canadensis) harvested in Arkansas, and report observations of cysts on wrists and ankles found on 12 otters. Cysts averaged 15.6 X 24.6 mm in size, were round to oval, and contained masses of up to 19 adult female Dracunculus sp...
February 19, 2018: Journal of Parasitology
https://www.readbyqxmd.com/read/29457580/food-and-beverage-intakes-according-to-physical-activity-levels-in-european-children-the-idefics-identification-and-prevention-of-dietary-and-lifestyle-induced-health-effects-in-children-and-infants-study
#2
Alba M Santaliestra-Pasías, Jaime E Llamas Dios, Ole Sprengeler, Antje Hebestreit, Stefaan De Henauw, Gabriele Eiben, Regina Felsö, Fabio Lauria, Michael Tornaritis, Toomas Veidebaum, Valeria Pala, Luis A Moreno
OBJECTIVE: Physical activity (PA) levels and dietary habits are considered some of the most important factors associated with obesity. The present study aimed to examine the association between PA level and food and beverage consumption in European children (2-10 years old). Design/Setting/Subjects A sample of 7229 children (49·0 % girls) from eight European countries participating in the IDEFICS (Identification and prevention of Dietary and lifestyle induced health EFfects In Children and infantS) study was included...
February 19, 2018: Public Health Nutrition
https://www.readbyqxmd.com/read/29457488/referral-patterns-and-implementation-costs-of-the-partners-in-recovery-initiative-in-gippsland-learnings-for-the-national-disability-insurance-scheme
#3
Anton N Isaacs, Kim Dalziel, Keith Sutton, Darryl Maybery
OBJECTIVE: The purpose of this paper is to provide some learnings for the NDIS from the referral pattern and cost of implementing the Partners in Recovery initiative of Gippsland. METHOD: Information on referral areas made for each consumer was collated from support facilitators. Cost estimates were determined using budget estimates, administrative costs and a literature review and are reported from a government perspective. RESULTS: Sixty-three per cent of all referrals were made to organisations that provided multiple types of services...
February 1, 2018: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/29457134/trophic-signatures-of-seabirds-suggest-shifts-in-oceanic-ecosystems
#4
Tyler O Gagne, K David Hyrenbach, Molly E Hagemann, Kyle S Van Houtan
Pelagic ecosystems are dynamic ocean regions whose immense natural capital is affected by climate change, pollution, and commercial fisheries. Trophic level-based indicators derived from fishery catch data may reveal the food web status of these systems, but the utility of these metrics has been debated because of targeting bias in fisheries catch. We analyze a unique, fishery-independent data set of North Pacific seabird tissues to inform ecosystem trends over 13 decades (1890s to 2010s). Trophic position declined broadly in five of eight species sampled, indicating a long-term shift from higher-trophic level to lower-trophic level prey...
February 2018: Science Advances
https://www.readbyqxmd.com/read/29455705/barriers-to-fruit-and-vegetable-consumption-among-farmers-market-incentive-programme-users-in-illinois-usa
#5
Chelsea R Singleton, Sydney Fouché, Rucha Deshpande, Angela Odoms-Young, Corey Chatman, Connie Spreen
OBJECTIVE: Previous research indicates that low-income individuals often struggle to consume the recommended amount of fruits and vegetables (F&V). LINK Up Illinois is a farmers' market incentive programme that aims to increase F&V consumption among Supplemental Nutrition Assistance Program (SNAP) recipients by improving access to and affordability of locally grown foods. The present research aimed to identify barriers to F&V consumption that exist among users of the LINK Up Illinois programme...
February 19, 2018: Public Health Nutrition
https://www.readbyqxmd.com/read/29455521/self-assembly-of-binuclear-cu-ii-histidine-complex-for-absolute-configuration-and-enantiomeric-excess-determination-of-naproxen-by-tandem-mass-spectrometry
#6
Xiangying Yu, Man-Chu Chau, Wai Kit Tang, Chi-Kit Siu, Zhong-Ping Yao
Naproxen is one of the most consumed non-steroidal anti-inflammatory drugs and marketed as S-naproxen since R-naproxen is hepatotoxic. In this study, chiral recognition of naproxen has been investigated by tandem mass spectrometry (MS/MS). Among all diastereomeric complexes formed between naproxen and the examined chiral selectors, including cyclodextrins (α/β/γ-CD), modified phenylalanines (N-acetyl-phenylalanine, N-t-butoxycarbonyl-phenylalanine, N-9-fluorenylmethyloxycarbonyl-phenylalanine), amino acids (Trp, Phe, Tyr, His), glucose, tartaric acid and vancomycin, a novel binuclear metal bound diastereomeric complexes [(M(II))2 (S/R-Naproxen)(L-His)2 -3H]+ (M = Cu, Ni or Co with Cu being the best) could allow effective identification of the absolute configuration of naproxen and determination of its enantiomeric excess (ee) through MS/MS analysis...
February 17, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29455517/highly-sensitive-bulk-silicon-chemical-sensors-with-sub-5-nanometer-thin-charge-inversion-layers
#7
Hossain M Fahad, Niharika Gupta, Rui Han, Sujay Bharat Desai, Ali Javey
There is an increasing demand for mass-producible, low-power gas sensors in a wide variety of industrial and consumer applications. Here, we report chemical sensitive field-effect-transistors (CS-FETs) based on bulk silicon wafers, wherein an electrostatically confined sub-5 nm thin charge inversion layer is modulated by chemical exposure to achieve a high sensitivity gas sensing platform. Using hydrogen sensing as a 'litmus' test, we demonstrate large sensor responses (> 1000%) to 0.5% H2 gas, with fast response (< 60 sec) and recovery times (< 120 sec) at room temperature and low power (<50µW)...
February 17, 2018: ACS Nano
https://www.readbyqxmd.com/read/29455334/septicemia-from-lactobacillus-rhamnosus-gg-from-a-probiotic-enriched-yogurt-in-a-patient-with-autologous-stem-cell-transplantation
#8
Satoshi Koyama, Hiroyuki Fujita, Takeshi Shimosato, Aki Kamijo, Yasufumi Ishiyama, Eri Yamamoto, Yoshimi Ishii, Yukako Hattori, Maki Hagihara, Etsuko Yamazaki, Naoto Tomita, Hideaki Nakajima
Probiotic-rich foods are consumed without much restriction. We report here, a case of septic shock caused by yogurt derived Lactobacillus species in a 54-year-old male patient with acute promyelocytic leukemia, in second complete remission, and who was an autologous stem cell transplantation recipient. He received high dose chemotherapy and autologous peripheral blood stem cell transplantation. He ingested commercially available probiotic-enriched yogurt because of severe diarrhea. One week later, he developed septic shock, and the pathogen was determined by strain-specific PCR analysis as Lactobacillus rhamnosus GG (ATCC 53103), which was found to be identical with the strain in the yogurt he consumed...
February 17, 2018: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/29455325/development-of-a-luminescence-syncytium-induction-assay-lusia-for-easily-detecting-and-quantitatively-measuring-bovine-leukemia-virus-infection
#9
Hirotaka Sato, Sonoko Watanuki, Hironobu Murakami, Reiichiro Sato, Hiroshi Ishizaki, Yoko Aida
Bovine leukemia virus (BLV) causes enzootic bovine leukosis and is closely related to the human T cell leukemia virus. Since BLV infection mostly occurs via cell-to-cell transmission, BLV infectivity is generally measured by culturing BLV-infected cells with reporter cells that form syncytia upon BLV infection. However, this method is time-consuming and requires skill. To visualize the infectivity of BLV, we developed a new assay called the luminescence syncytium induction assay (LuSIA) that is based on a new reporter cell line designated CC81-BLU3G...
February 17, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29455319/development-and-pilot-testing-of-a-decision-aid-for-genomic-research-participants-notified-of-clinically-actionable-research-findings-for-cancer-risk
#10
Amanda M Willis, Sian K Smith, Bettina Meiser, Mandy L Ballinger, David M Thomas, Martin Tattersall, Mary-Anne Young
Germline genomic testing is increasingly used in research to identify genetic causes of disease, including cancer. However, there is evidence that individuals who are notified of clinically actionable research findings have difficulty making informed decisions regarding uptake of genetic counseling for these findings. This study aimed to produce and pilot test a decision aid to assist participants in genomic research studies who are notified of clinically actionable research findings to make informed choices regarding uptake of genetic counseling...
February 17, 2018: Journal of Genetic Counseling
https://www.readbyqxmd.com/read/29453677/changes-in-medicine-prescription-following-a-medication-review-in-older-high-risk-patients-with-polypharmacy
#11
Marian Z M Hurmuz, Sarah I M Janus, Jeannette G van Manen
Background The more (inappropriate) drugs a patient uses, the higher the risk of drug related problems. To reduce these risks, medication reviews can be performed. Objective To report changes in the prescribed number of (potentially inappropriate) drugs before and after performing a medication review in high-risk polypharmacy patients. A secondary objective was to study reasons for continuing potentially inappropriate drugs (PIDs). Setting Dutch community pharmacy and general medical practice. Methods A retrospective longitudinal intervention study with a pre-test/post-test design and follow-up of 1 week and 3 months was performed...
February 17, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29453549/the-german-reach-congress-2016-a-workshop-report
#12
Antonia Reihlen, Dirk Jepsen, Lutz Broschinski, Andreas Luch, Agnes Schulte
In October 2016, the German REACH Congress was held at the German Federal Institute for Risk Assessment (BfR) in Berlin. Here, the associated improvement made in the fields of consumer protection and the progress in and experiences gained from the implementation of the authorisation procedure were discussed. Several speakers from EU institutions, German authorities, industry, and civil society organisations were invited to present their views. There was a shared consensus that REACH contributes to the advancement of consumer protection against chemical risks, mainly because more and higher quality information on substance-related hazards and potential exposures becomes available...
February 17, 2018: Archives of Toxicology
https://www.readbyqxmd.com/read/29450250/association-between-drug-use-and-urban-violence-data-from-the-ii-brazilian-national-alcohol-and-drugs-survey-bnads
#13
Renata Rigacci Abdalla, Luciana Massaro, André de Queiroz Constantino Miguel, Ronaldo Laranjeira, Raul Caetano, Clarice S Madruga
Objective: To investigate the association of alcohol and cocaine use with urban violence (both as victim and as perpetrator) in a representative sample of the Brazilian population. Method: The Second Brazilian Alcohol and Drugs Survey (II BNADS) interviewed 4607 individuals aged 14 years and older from the Brazilian household population including an oversample of 1157 adolescents (14 to 18 years old). The survey gathered information on alcohol, tobacco and illegal substances use as well as on risk factors for abuse and dependence, behaviors associated with the use of substances and the possible consequences, as urban violence indicators...
June 2018: Addictive Behaviors Reports
https://www.readbyqxmd.com/read/29450221/drinking-game-participation-gender-performance-and-normalization-of-intoxication-among-nigerian-university-students
#14
Emeka Dumbili, Clare Williams
Background: Most research on drinking games (DGs) and the associated risks focuses on Western countries. In the Nigerian context, DGs activity has not attracted scholarly attention but growing media reports indicate that Nigerian youths play DGs, and that a number of gamers have died during or immediately after game-playing. Methods: Drawing on gender performance scripts, we explored the performance of gender through DGs practices and the factors that motivate DGs participation...
June 2017: Addictive Behaviors Reports
https://www.readbyqxmd.com/read/29449933/a-simplified-characterization-of-s-adenosyl-l-methionine-consuming-enzymes-with-1-step-ez-mtase-a-universal-and-straightforward-coupled-assay-for-in-vitro-and-in-vivo-setting
#15
Emmanuel S Burgos, Ryan O Walters, Derek M Huffman, David Shechter
Methyltransferases use S -adenosyl-l-methionine (SAM) to deposit methyl marks. Many of these epigenetic 'writers' are associated with gene regulation. As cancer etiology is highly correlated with misregulated methylation patterns, methyltransferases are emerging therapeutic targets. Successful assignment of methyltransferases' roles within intricate biological networks relies on (1) the access to enzyme mechanistic insights and (2) the efficient screening of chemical probes against these targets. To characterize methyltransferases in vitro and in vivo , we report a highly-sensitive one-step deaminase-linked continuous assay where the S -adenosyl-l-homocysteine (SAH) enzyme-product is rapidly and quantitatively catabolized to S -inosyl-l-homocysteine (SIH)...
September 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/29447152/a-multiscale-modelling-approach-to-assess-the-impact-of-metabolic-zonation-and-microperfusion-on-the-hepatic-carbohydrate-metabolism
#16
Nikolaus Berndt, Marius Stefan Horger, Sascha Bulik, Hermann-Georg Holzhütter
The capacity of the liver to convert the metabolic input received from the incoming portal and arterial blood into the metabolic output of the outgoing venous blood has three major determinants: The intra-hepatic blood flow, the transport of metabolites between blood vessels (sinusoids) and hepatocytes and the metabolic capacity of hepatocytes. These determinants are not constant across the organ: Even in the normal organ, but much more pronounced in the fibrotic and cirrhotic liver, regional variability of the capillary blood pressure, tissue architecture and the expression level of metabolic enzymes (zonation) have been reported...
February 15, 2018: PLoS Computational Biology
https://www.readbyqxmd.com/read/29446502/alcohol-pattern-of-drinking-and-all-cause-mortality-in-russia-belarus-and-hungary-a-retrospective-indirect-cohort-study-based-on-mortality-of-relatives
#17
Pia Horvat, Denes Stefler, Michael Murphy, Lawrence King, Martin McKee, Martin Bobak
AIMS: To assess the relationship between alcohol intake frequency and mortality among males and females in three Eastern European populations, and to estimate the additional mortality risk posed by a combination of frequent drinking, binge drinking and other hazardous drinking habits. DESIGN: Retrospective cohort study; the cohort consisted of close relatives of survey participants. SETTING: Middle-sized settlements in Russia, Belarus and Hungary...
February 15, 2018: Addiction
https://www.readbyqxmd.com/read/29445814/anisotropic-flexible-transparent-films-from-remaining-wood-microstructures-for-screen-protection-and-agnw-conductive-substrate
#18
Qiheng Tang, Lu Fang, YunFei Wang, Miao Zou, Wenjing Guo
Flexible transparent conductive films or substrates prepared from plastics or cellulose are widely used in optoelectronic devices. However, all of these films or substrates are fabricated by complex and expensive methods, which consume much energy and time. In this work, we report for the first time a remarkably facile and effective approach for fabricating flexible transparent films directly from wood. The resulting films exhibit an array of exceptional optical and mechanical properties. The well-aligned cell structures in natural wood are maintained during delignification, leading to anisotropic films with high transparency (≈90% transmittance)...
February 15, 2018: Nanoscale
https://www.readbyqxmd.com/read/29445521/a-method-for-co-creation-of-an-evidence-based-patient-workbook-to-address-alcohol-use-when-quitting-smoking-in-primary-care-a-case-study
#19
Nadia Minian, Aliya Noormohamed, Laurie Zawertailo, Dolly Baliunas, Norman Giesbrecht, Bernard Le Foll, Jürgen Rehm, Andriy Samokhvalov, Peter L Selby
Plain English summary: The purpose of this paper is to describe a patient engagement event designed to create an educational workbook with smokers who drink alcohol at harmful levels. The goal was to create a workbook that combined scientific evidence with patients' values, preferences, and needs. Fourteen adult smokers who drink alcohol were invited to the Centre for Addiction and Mental Health (CAMH) to take part in a four-hour event to help design the workbook with the CAMH research team...
2018: Research involvement and engagement
https://www.readbyqxmd.com/read/29445268/genome-editing-applications-of-crispr-cas9-to-promote-in-vitro-studies-of-alzheimer-s-disease
#20
REVIEW
Vo Van Giau, Hyon Lee, Kyu Hwan Shim, Eva Bagyinszky, Seong Soo A An
Genetic variations play an important role in the clinical presentation and progression of Alzheimer's disease (AD), especially early-onset Alzheimer's disease. Hundreds of mutations have been reported with the majority resulting from alterations in β-amyloid precursor protein ( APP ), presenilin 1 ( PSEN1 ), or presenilin 2 ( PSEN2 ) genes. The roles of these mutations in the pathogenesis of AD have been classically confirmed or refuted through functional studies, where the mutations are cloned, inserted into cell lines, and monitored for changes in various properties including cell survival, amyloid production, or Aβ42/40 ratio...
2018: Clinical Interventions in Aging
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