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https://www.readbyqxmd.com/read/29035921/biphasic-effects-of-selective-serotonin-reuptake-inhibitors-on-anxiety-rapid-reversal-of-escitalopram-s-anxiogenic-effects-in-the-novelty-induced-hypophagia-test-in-mice
#1
Wouter Koek, Nathan C Mitchell, Lynette C Daws
In humans, chronic treatment with selective serotonin reuptake inhibitors (SSRIs) decreases anxiety, unlike acute treatment, which can increase anxiety. Although this biphasic pattern is observed clinically, preclinical demonstrations are rare. In an animal model of antidepressant-induced anxiolytic effects, the novelty-induced hypophagia (NIH) test, a single administration of the SSRI citalopram reportedly elicited anxiogenic-like effects, whereas three administrations over 24 h were sufficient to produce anxiolytic-like effects...
October 13, 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29035344/a-phase-intensity-surface-plasmon-resonance-biosensor-for-avian-influenza-a-h5n1-detection
#2
Chi Lok Wong, Marissa Chua, Heather Mittman, Li Xian Choo, Hann Qian Lim, Malini Olivo
In this paper, we present a phase-intensity surface plasmon resonance (SPR) biosensor and demonstrate its use for avian influenza A (H5N1) antibody biomarker detection. The sensor probes the intensity variation produced by the steep phase response at surface plasmon excitation. The prism sensor head is fixed between a pair of polarizers with a perpendicular orientation angle and a forbidden transmission path. At SPR, a steep phase change is introduced between the p- and s-polarized light, and this rotates the polarization ellipse of the transmission beam...
October 16, 2017: Sensors
https://www.readbyqxmd.com/read/29033988/comparing-the-effect-of-auriculotherapy-and-vitamin-b6-on-the-symptoms-of-premenstrual-syndrome-among-the-students-who-lived-in-the-dorm-of-isfahan-university-of-medical-sciences
#3
Sharareh Koleini, Mahboubeh Valiani
BACKGROUND: Premenstrual syndrome (PMS) is a series of physical and psychological symptoms before menstruation which its prevalence around the world has been reported to be 80%. Consumption of vitamin B6 is a common treatment for this syndrome, and this study was conducted to compare the effect of auriculotherapy and vitamin B6 on the symptoms of premenstrual syndrome. MATERIALS AND METHODS: This study was a clinical trial. Eighty-four female students who lived at the university dorm were randomly selected and allocated into two groups of 42...
September 2017: Iranian Journal of Nursing and Midwifery Research
https://www.readbyqxmd.com/read/29033668/integrative-research-identifies-71-new-plant-species-records-in-the-state-of-rio-grande-do-norte-brazil-and-enhances-a-small-herbarium-collection-during-a-funding-shortage
#4
Leonardo M Versieux, Nállarett Dávila, Geadelande C Delgado, Valdeci F de Sousa, Edweslley Otaviano de Moura, Tarciso Filgueiras, Marccus V Alves, Eric Carvalho, Daniel Piotto, Rafaela C Forzza, Alice Calvente, Jomar G Jardim
A National Forest Inventory (NFI) encompassing the entire territory of Brazil is in progress. It is coordinated and promoted by the Brazilian Forest Service of the Ministry of Environment. In each state, the NFI collaborates with local herbaria by receiving collected plant material and performing species identification. Consultants are hired by the NFI and work at the local herbaria under the supervision of a curator. In exchange for curatorial assistance, the NFI provides equipment and consumables for the herbarium...
2017: PhytoKeys
https://www.readbyqxmd.com/read/29033463/an-examination-of-the-most-recent-episode-of-molly-use-among-college-students
#5
Amy L Stamates, Ashley N Linden-Carmichael, Brynn E Sheehan, Peter D Preonas, Cathy Lau-Barraco
OBJECTIVE: The current study examined event-level characteristics (e.g., contextual factors, risk behaviors) during the most recent episode of Molly use among a sample of college students who reported previously using Molly. PARTICIPANTS: Participants (N = 151; 66.7% female) were drinkers aged 18 to 25. Data were collected from October to November 2014, February to April 2015, and September to November 2015. METHOD: Participants completed measures regarding typical Molly use and items related to context and behaviors during their most recent episode of Molly use...
2017: Journal of Drug Issues
https://www.readbyqxmd.com/read/29032623/complementary-feeding-practices-current-global-and-regional-estimates
#6
Jessica M White, France Bégin, Richard Kumapley, Colleen Murray, Julia Krasevec
Insufficient quantities and inadequate quality of complementary foods, together with poor feeding practices, pose a threat to children's health and nutrition. Interventions to improve complementary feeding are critical to reduce all forms of malnutrition, and access to data to ascertain the status of complementary feeding practices is essential for efforts to improve feeding behaviours. However, sufficient data to generate estimates for the core indicators covering the complementary feeding period only became available recently...
October 2017: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/29031765/an-increased-autophagic-flux-contributes-to-the-anti-inflammatory-potential-of-urolithin-a-in-macrophages
#7
Yaw Duah Boakye, Laura Groyer, Elke H Heiss
BACKGROUND: An extract of Phyllanthus muellerianus and its constituent geraniin have been reported to exert anti-inflammatory activity in vivo. However, orally consumed geraniin, an ellagitannin, shows low bioavailability and undergoes metabolization to urolithins by gut microbiota. This study aimed at comparing geraniin and urolithin A with respect to inhibition of M1 (LPS) polarization of murine J774.1 macrophages and shedding more light on possible underlying mechanisms. METHODS: Photometric, fluorimetric as well as luminescence-based assays monitored production of reactive oxygen species (ROS) and nitric oxide (NO), cell viability or reporter gene expression...
October 11, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29031295/competitive-amperometric-immunosensor-for-determination-of-p53-protein-in-urine-with-carbon-nanotubes-gold-nanoparticles-screen-printed-electrodes-a-potential-rapid-and-noninvasive-screening-tool-for-early-diagnosis-of-urinary-tract-carcinoma
#8
Marco Giannetto, Maria Vittoria Bianchi, Monica Mattarozzi, Maria Careri
Since p53 protein has become recognized biomarker for both diagnostic and therapeutic purposes in oncological diseases with particular relevance for bladder cancer, it is highly desirable to search for a novel sensing tool for detecting the patient's p53 level at the early stage. Here we report the first study on the development and validation of a novel disposable competitive amperometric immunosensor for determination of p53 protein at subnanomolar levels, based on p53 immobilization on gold nanoparticles/carbon nanotubes modified screen-printed carbon electrodes...
October 23, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29030445/microhomology-mediated-high-throughput-gene-inactivation-strategy-for-hyperthermophilic-crenarchaeon-sulfolobus-islandicus
#9
Changyi Zhang, Rachel J Whitaker
Sulfolobus islandicus is rapidly emerging as a model system for studying the biology and evolution within the TACK lineage of the Archaeal domain. As the tree of life grows, identifying the cellular function of genes within this lineage will have significant impacts on our understanding of the evolution of Last Archaeal Eukaryote Common Ancestor (LEACA) and the differentiation of Archaea from Eukaryotes during the evolution of the modernday cell. To progress our understanding of this key Archaeal organism, we report a novel high-throughput method for targeted gene inactivation in S...
October 13, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29030443/a-novel-metabolic-pathway-for-n-methylpyrrolidone-degradation-in-alicycliphilus-sp-bq1
#10
Claudia Julieta Solís-González, Lilianha Domínguez-Malfavón, Martín Vargas-Suárez, Itzel Gaytán, Miguel Ángel Cevallos, Luis Lozano, M Javier Cruz-Gómez, Herminia Loza-Tavera
The molecular mechanisms underlying the biodegradation of N-Methylpyrrolidone (NMP), a widely used industrial solvent that produces skin irritation in humans, and is teratogenic in rats, are unknown. Alicycliphilus sp. BQ1 degrades NMP. By studying a transposon-tagged mutant unable to degrade NMP, we identified a six-gene cluster (nmpABCDEF), transcribed as a polycistronic mRNA, encoding enzymes involved in NMP biodegradation. nmpA and the transposon-affected gene nmpB encode a N-methylhydantoin amidohydrolase that would transform NMP to γ-N-methylaminobutyric acid; this would be metabolized by an aminoacid oxidase (NMPC), either by demethylation to produce γ-aminobutyric acid (GABA), or by deamination to produce succinate semialdehyde (SSA)...
October 13, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29030326/consumer-health-related-activities-on-social-media-exploratory-study
#11
Arcelio Benetoli, Timothy F Chen, Parisa Aslani
BACKGROUND: Although a number of studies have investigated how consumers use social media for health-related purposes, there is a paucity of studies in the Australian context. OBJECTIVE: This study aimed to explore how Australian consumers used social media for health-related purposes, specifically how they identified social media platforms, which were used, and which health-related activities commonly took place. METHODS: A total of 5 focus groups (n=36 participants), each lasting 60 to 90 minutes, were conducted in the Sydney metropolitan area...
October 13, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29029399/a-cellular-platform-for-the-evaluation-of-immune-checkpoint-molecules
#12
Sabrina Jutz, Annika Hennig, Wolfgang Paster, Ömer Asrak, Dejana Dijanovic, Florian Kellner, Winfried F Pickl, Johannes B Huppa, Judith Leitner, Peter Steinberger
Blockade of the T cell coinhibitory molecules CTLA-4 and PD-1 has clinical utility to strengthen T cell responses. In addition to these immune checkpoints an ever-growing number of molecules has been implicated in generating coinhibitory signals in T cells. However, investigating coinhibitory molecules in primary human cells is complicated by the restricted expression and promiscuity of both coinhibitory receptors and their ligands. Here we have evaluated the potential of fluorescence-based transcriptional reporters based on the human Jurkat T cell line in conjunction with engineered T cell stimulator cell lines for investigating coinhibitory pathways...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29029219/pupation-behavior-and-predation-on-drosophila-suzukii-diptera-drosophilidae-pupae-in-maine-wild-blueberry-fields
#13
Elissa S Ballman, Judith A Collins, Francis A Drummond
Drosophila suzukii (Matsumura; Diptera: Drosophilidae) is an invasive vinegar fly and pest of soft fruits in North America, including wild blueberries (Vaccinium angustifolium Aiton) in Maine. Despite its presence in the continental United States for 9 yr, little is known about its natural enemy complex. Here we report the results of a 3-yr study designed to identify naturally-occurring predators in Maine's wild blueberry fields. Experiments were conducted to determine pupation site and pupation depth to understand D...
September 27, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/29028588/formation-of-struvite-urinary-stones-and-approaches-towards-the-inhibition-a-review
#14
REVIEW
Poppy Das, Gaurav Gupta, Vinodhini Velu, Rajendra Awasthi, Kamal Dua, Himaja Malipeddi
BACKGROUND: Struvite is one of the most common urinary/kidney stones, composed of magnesium ammonium phosphate (MgNHPO4·H2O). They are also termed as infection stones as these are associated with urinary tract infections. Numerous studies have been carried out to examine the growth and inhibition of struvite stones. OBJECTIVE: This review summarizes various reports on the factors responsible for inducing struvite stones in the kidney and gives a detailed account of studies on inhibition of growth of struvite crystals...
October 10, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29028269/acceptance-and-adoption-of-biofortified-crops-in-low-and-middle-income-countries-a-systematic-review
#15
Elise F Talsma, Alida Melse-Boonstra, Inge D Brouwer
Biofortification of staple crops is a promising strategy for increasing the nutrient density of diets in order to improve human health. The willingness of consumers and producers to accept new crop varieties will determine whether biofortification can be successfully implemented. This review assessed sensory acceptance and adoption of biofortified crops and the determining factors for acceptance and adoption among consumers and producers in low- and middle-income countries. PubMed, Scopus, and Web of Science were searched for published reports...
October 1, 2017: Nutrition Reviews
https://www.readbyqxmd.com/read/29028071/how-to-isolate-a-ready-to-use-adipose-derived-stem-cells-pellet-for-clinical-application
#16
E Raposio, N Bertozzi
Adipose-derived stem cells (ASCs) are multipotent mesenchymal stem cells (MSCs) that show definitive stem cell characteristics such as plastic adherence in culture, ability to maintain multipotency upon in vitro expansion, and self-renewal capacity. ASCs are particularly promising for use in regenerative medicine because they can be harvested easily from adipose tissue by standard liposuction, with minimal donor site morbidity. Since ASCs do not necessitate ex vivo expansion to obtain clinically significant cell numbers, it is critical to identify a standardized method that maximizes the number of ASCs collected...
September 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29027283/does-managing-the-consumption-of-people-with-severe-alcohol-dependence-reduce-harm-a-comparison-of-participants-in-six-canadian-managed-alcohol-programs-with-locally-recruited-controls
#17
Tim Stockwell, Bernie Pauly, Clifton Chow, Rebekah A Erickson, Bonnie Krysowaty, Audra Roemer, Kate Vallance, Ashley Wettlaufer, Jinhui Zhao
INTRODUCTION AND AIMS: Managed alcohol programs (MAP) are intended for people with severe alcohol-related problems and unstable housing. We investigated whether MAP participation was associated with changes in drinking patterns and related harms. DESIGN AND METHODS: One hundred and seventy-five MAP participants from five Canadian cities (Hamilton, Ottawa, Toronto, Thunder Bay and Vancouver) and 189 same-city controls were assessed for alcohol consumption, health, safety and harm outcomes...
October 13, 2017: Drug and Alcohol Review
https://www.readbyqxmd.com/read/29027135/does-coenzyme-q10-supplementation-mitigate-statin-associated-muscle-symptoms-pharmacological-and-methodological-considerations
#18
REVIEW
Beth A Taylor
Statin drugs markedly reduce low-density lipoprotein cholesterol and consequently the incidence of cardiac events. In approximately 5-10% of adults, these drugs are associated with a range of muscle side effects such as muscle pain, cramping and weakness. Reduction in mitochondrial coenzyme Q10 (CoQ10), or ubiquinone, has been proposed as a mechanism for these statin-associated muscle symptoms (SAMS), and thus various formulations of CoQ10 are marketed and consumed for the prevention and treatment of SAMS. However, data supporting the efficacy of CoQ10 are equivocal, with some studies showing that CoQ10 supplementation reduces the incidence and severity of SAMS and others finding no beneficial effects of supplementation...
October 12, 2017: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
https://www.readbyqxmd.com/read/29026754/medication-discrepancies-and-potentially-inadequate-prescriptions-in-elderly-adults-with-polypharmacy-in-ambulatory-care
#19
Juan Víctor Ariel Franco, Sergio Adrián Terrasa, Karin Silvana Kopitowski
OBJECTIVES: The objective of this study is to describe the frequency and type of medication discrepancies (MD) through medication reconciliation and to describe the frequency of potentially inadequate prescription (PIP) medications using screening tool of older persons' prescriptions criteria. DESIGN: Cross-sectional comparison of electronic medical record (EMR) medication lists and patient's self-report of their comprehensive medication histories obtained through telephone interviews...
January 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29025876/mevalonate-5-diphosphate-mediates-atp-binding-to-the-mevalonate-diphosphate-decarboxylase-from-the-bacterial-pathogen-enterococcus-faecalis
#20
Chun-Liang Chen, James C Mermoud, Lake N Paul, Calvin Nicklaus Steussy, Cynthia V Stauffacher
The mevalonate pathway produces isopentenyl diphosphate (IPP), a building block for polyisoprenoid synthesis, and is a crucial pathway for growth of the human bacterial pathogen Enterococcus faecalis. The final enzyme in this pathway, mevalonate diphosphate decarboxylase (MDD), acts on mevalonate diphosphate (MVAPP) to produce IPP while consuming ATP. This essential enzyme has been suggested as a therapeutic target for the treatment of drug-resistant bacterial infections. Here we report functional and structural studies on the mevalonate diphosphate decarboxylase from E...
October 12, 2017: Journal of Biological Chemistry
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