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https://www.readbyqxmd.com/read/28340233/increase-in-drug-overdose-deaths-involving-fentanyl-rhode-island-january-2012-march-2014
#1
Melissa C Mercado, Steven A Sumner, M Bridget Spelke, Michele K Bohm, David E Sugerman, Christina Stanley
Objective.:  This study identified sociodemographic, substance use, and multiple opioid prescriber and dispenser risk factors among drug overdose decedents in Rhode Island, in response to an increase in overdose deaths (ODs) involving fentanyl. Methods.:  This cross-sectional investigation comprised all ODs reviewed by Rhode Island's Office of the State Medical Examiners (OSME) during January 2012 to March 2014. Data for 536 decedents were abstracted from OSME's charts, death certificates, toxicology reports, and Prescription Monitoring Program (PMP) databases...
March 6, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28340030/effects-of-consumer-oriented-health-information-technologies-in-diabetes-management-over-time-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#2
Da Tao, Tieyan Wang, Tieshan Wang, Shuang Liu, Xingda Qu
Objective: To reveal the effects of consumer-oriented health information technologies (CHITs) on patient outcomes in diabetes management over time through systematic review and meta-analysis. Methods: We searched 5 electronic databases (from database inception to July 2016) for studies that reported on randomized controlled trials examining the effects of CHITs on glycemic control and other patient outcomes in diabetes management. Data were analyzed using either meta-analysis or a narrative synthesis approach...
March 9, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/28339731/obesity-associated-cardiac-pathogenesis-in-broiler-breeder-hens-development-of-metabolic-cardiomyopathy2-3
#3
C Y Chen, Y F Huang, Y J Ko, Y J Liu, Y H Chen, R L Walzem, S E Chen
Feed intake is typically restricted (R) in broiler hens to avoid obesity and improve egg production and livability. To determine whether improved heart health contributes to improved livability, fully adult 45-week-old R hens were allowed to consume feed to appetite (ad libitum; AL) up to 10 wk (70 d). Mortality, contractile functions, and morphology at 70 d, and measurements of cardiac hypertrophic remodeling at 7 d and 21 d were made and compared between R and AL hens. Outcomes for cardiac electrophysiology and mortality, reported separately, found increased mortality in AL hens in association with cardiac pathological hypertrophy and contractile dysfunction...
February 22, 2017: Poultry Science
https://www.readbyqxmd.com/read/28339468/pbmda-a-novel-and-effective-path-based-computational-model-for-mirna-disease-association-prediction
#4
Zhu-Hong You, Zhi-An Huang, Zexuan Zhu, Gui-Ying Yan, Zheng-Wei Li, Zhenkun Wen, Xing Chen
In the recent few years, an increasing number of studies have shown that microRNAs (miRNAs) play critical roles in many fundamental and important biological processes. As one of pathogenetic factors, the molecular mechanisms underlying human complex diseases still have not been completely understood from the perspective of miRNA. Predicting potential miRNA-disease associations makes important contributions to understanding the pathogenesis of diseases, developing new drugs, and formulating individualized diagnosis and treatment for diverse human complex diseases...
March 24, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28334842/enhanced-hplc-dad-method-for-fast-determination-of-quercetin-3-o-%C3%AE-d-glucoside-in-extracts-and-polyherbal-formulations-containing-azadirachta-indica-optimization-and-validation
#5
Sonal Desai, Pratima Tatke, Satish Gabhe
Azadirachta indica has been used for its medicinal properties since time immemorial. Herbal medicines which are prepared using this medicinal tree are utilized to treat various diseases and disorders. No reports are available for marker-based standardization of these herbal medicines prepared from leaves of A. indica. Also existing HPLC methods for determination quercetin-3-O-β-d-glucoside are time consuming. There is an obvious need for development of new HPLC method for quantification of quercetin-3-O-β-d-glucoside which is fast enough to carry out analysis in stipulated time period...
March 18, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28334753/alcohol-screening-among-young-people-a-prospective-study-from-the-swiss-sentinel-surveillance-system-sentinella-of-physicians-a-priori-opinions
#6
Coralie Wenger-Bonny, Adjua Alexandra N'goran, Jérôme Pasquier, Charles Dvorak, Dagmar M Haller, Lilli Herzig
Background.: Systematic screening for excessive alcohol use among young people is recommended but rarely implemented. Family practitioners tend to select patients for screening, based on their preliminary subjective opinions, which may be biased. Objective.: To evaluate the ability of family practitioners to identify excessive alcohol use among young people prior to screening them. Methods.: This prospective study was conducted through Sentinella, an epidemiological network involving 150 family practitioners across Switzerland...
February 22, 2017: Family Practice
https://www.readbyqxmd.com/read/28334678/evaluating-the-effect-of-conservation-motivations-on-residential-water-demand
#7
Alexander Maas, Christopher Goemans, Dale Manning, Stephan Kroll, Mazdak Arabi, Mariana Rodriguez-McGoffina
Utilities and water suppliers in the southwestern United States have used education and conservation programs over the past two decades in an attempt to ameliorate the pressures of increasing water scarcity. This paper builds on a long history of water demand and environmental psychology literature and attempts to answer a simple question: do households primarily motivated by environmental and social (E&S) considerations consume water differently than households motivated primarily by cost and convenience (C&C)? We find that E&S consumers use less water than C&C consumers on average...
March 20, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28334625/magnetic-microspheres-based-cytometric-bead-array-assay-for-highly-sensitive-detection-of-ochratoxin-a
#8
Weijun Kong, Changbin Xiao, Guangyao Ying, Xiaofei Liu, Xiaohong Zhao, Ruilin Wang, Li Wan, Meihua Yang
Accurate and sensitive quantification of a specific class of mycotoxins at trace levels in complex matrices with greener approaches is of significant importance. In this study, a green and economical protocol of magnetic microspheres-based cytometric bead array (CBA) assay on indirect competitive principle was developed for sensitive and rapid detection of ochratoxin A (OTA) in malts with a small number of standard and sample solutions. The protocol included the competition of OTA in malt samples and that covalently coupled on the surface of microspheres with its monoclonal antibodies, the separation and aggregation of the magnetic microspheres, and the fluorescence detection of fluorescein isothiocyanate labeled goat anti-mouse immunoglobulin G probes...
March 14, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28334386/effects-of-xylem-sap-composition-on-glassy-winged-sharpshooter-hemiptera-cicadellidae-egg-maturation-on-high-and-low-quality-host-plants
#9
Mark S Sisterson, Christopher M Wallis, Drake C Stenger
Glassy-winged sharpshooters must feed as adults to produce mature eggs. Cowpea and sunflower are both readily accepted by the glassy-winged sharpshooter for feeding, but egg production on sunflower was reported to be lower than egg production on cowpea. To better understand the role of adult diet in egg production, effects of xylem-sap chemistry on glassy-winged sharpshooter egg maturation was compared for females confined to cowpea and sunflower. Females confined to cowpea consumed more xylem-sap than females held on sunflower...
March 6, 2017: Environmental Entomology
https://www.readbyqxmd.com/read/28332449/estimated-daily-intake-and-safety-of-fd-c-food-colour-additives-in-the-us-population
#10
Maria Bastaki, Thomas Farrell, Sachin Bhusari, Xiaoyu Bi, Carolyn Scrafford
A refined exposure assessment was undertaken to calculate the Estimated Daily Intake (EDI) of the seven FD&C straight colour additives and five FD&C colour lakes ("synthetic" food colours) approved in the United States (US). The EDIs were calculated for the US population as a whole and specific age groups, including children 2-5 y, children 6-12 y, adolescents 13-18 y, and adults 19+ y. Actual use data were collected from an industry survey of companies who are users of these colour additives in a variety of products, with additional input from food colour manufacturers...
March 23, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/28332244/a-fluorine-18-radiolabelling-method-enabled-by-rhenium-i-complexation-circumvents-the-requirement-of-anhydrous-conditions
#11
Mitchell Ashley Klenner, Giancarlo Pascali, Bo Zhang, Tiffany Russel Sia, Lawson Kyle Spare, Anwen M Krause-Heuer, Janice Aldrich-Wright, Ivan Greguric, Adam Guastella, Massimiliano Massi, Benjamin Hugh Fraser
Azeotropic distillation is typically required to achieve fluorine-18 radiolabelling during the production of positron emission tomography (PET) imaging agents. However, this time consuming process also limits fluorine-18 incorporation, due to radioactive decay of the isotope and its adsorption to the drying vessel. In addressing these limitations, we herein report the fluorine-18 radiolabelling of one model rhenium(I) complex, which is significantly improved under conditions that do not require azeotropic drying...
March 22, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28331089/diversity-distribution-and-evolution-of-tomato-viruses-in-china-uncovered-by-small-rna-sequencing
#12
Chenxi Xu, Xuepeng Sun, Angela Taylor, Chen Jiao, Yimin Xu, Xiaofeng Cai, Xiaoli Wang, Chenhui Ge, Guanghui Pan, Quanxi Wang, Zhangjun Fei, Quanhua Wang
Tomato is a major vegetable crop that has tremendous popularity. However, viral disease is still a major factor limiting tomato production. Here we report the tomato virome identified through sequencing small RNAs of 170 field-grown samples collected in China. A total of 22 viruses were identified including both well-documented and newly detected viruses. The tomato viral community is dominated by a few species, and they exhibit polymorphisms and recombination in the genomes with coldspots and hotspots. Most samples were co-infected by multiple viruses and the majority of identified viruses are positive-sense single-stranded RNA viruses...
March 22, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28331062/hypoxia-inducible-factor-1%C3%AE-activation-improves-renal-oxygenation-and-mitochondrial-function-in-early-chronic-kidney-disease
#13
Joanna L Thomas, Hai Pham, Ying Li, Elanore Hall, Guy A Perkins, Sameh S Ali, Hemal H Patel, Prabhleen Singh
Pathophysiology of chronic kidney disease (CKD) is driven by alterations in surviving nephrons to sustain renal function with ongoing nephron loss. Oxygen supply-demand mismatch, due to hemodynamic adaptations, with resultant hypoxia, plays an important role in the pathophysiology in early CKD. We sought to investigate the underlying mechanisms of this mismatch. We utilized the subtotal nephrectomy (STN) model of CKD to investigate the alterations in renal oxygenation linked to sodium (Na) transport and mitochondrial function in the surviving nephrons...
March 22, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28330970/variation-in-family-experience-of-pediatric-inpatient-care-as-measured-by-child-hcahps
#14
Sara L Toomey, Marc N Elliott, Alan M Zaslavsky, David J Klein, Sifon Ndon, Shannon Hardy, Melody Wu, Mark A Schuster
BACKGROUND: Making national comparisons of family experience of inpatient pediatric care has been limited by the lack of a publicly available survey. The Agency for Healthcare Research and Quality and Centers for Medicare & Medicaid Services commissioned development of the Child Hospital Consumer Assessment of Healthcare Providers and Systems Survey to address this gap. Using Child Hospital Consumer Assessment of Healthcare Providers and Systems Survey, we measured performance of hospitals in a national field test...
March 22, 2017: Pediatrics
https://www.readbyqxmd.com/read/28330728/a-cross-sectional-study-of-the-relationship-between-nutrition-label-use-and-food-selection-servings-and-consumption-in-a%C3%A2-university-dining-setting
#15
Mary J Christoph, Brenna Ellison
BACKGROUND: Nutrition labels at the point of purchase are recommended to improve food choice, yet food choice does not always translate into food consumption. It is important to understand the relationship between label use, food selection, servings, and consumption. Previous research, which has relied on self-reported intake or inferred label use or intake based on sales data, has not adequately answered this question. OBJECTIVE: To combine survey and meal photographic data to compare food selection, servings, and consumption between label users and nonusers...
March 16, 2017: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/28330465/the-impact-of-non-response-bias-due-to-sampling-in-public-health-studies-a-comparison-of-voluntary-versus-mandatory-recruitment-in-a-dutch-national-survey-on-adolescent-health
#16
Kei Long Cheung, Peter M Ten Klooster, Cees Smit, Hein de Vries, Marcel E Pieterse
BACKGROUND: In public health monitoring of young people it is critical to understand the effects of selective non-response, in particular when a controversial topic is involved like substance abuse or sexual behaviour. Research that is dependent upon voluntary subject participation is particularly vulnerable to sampling bias. As respondents whose participation is hardest to elicit on a voluntary basis are also more likely to report risk behaviour, this potentially leads to underestimation of risk factor prevalence...
March 23, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28329785/beet-root-juice-an-ergogenic-aid-for-exercise-and-the-aging-brain
#17
Meredith Petrie, W Jack Rejeski, Swati Basu, Paul J Laurienti, Anthony P Marsh, James L Norris, Daniel B Kim-Shapiro, Jonathan H Burdette
Background: Exercise has positive neuroplastic effects on the aging brain. It has also been shown that ingestion of beet root juice (BRJ) increases blood flow to the brain and enhances exercise performance. Here, we examined whether there are synergistic effects of BRJ and exercise on neuroplasticity in the aging brain. Methods: Peak metabolic equivalent (MET) capacity and resting-state magnetic resonance imaging functional brain network organization are reported on 26 older (mean age = 65...
November 9, 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28329019/a-cross-sectional-analysis-of-traditional-medicine-use-for-malaria-alongside-free-antimalarial-drugs-treatment-amongst-adults-in-high-risk-malaria-endemic-provinces-of-indonesia
#18
Dwi Linna Suswardany, David W Sibbritt, Sudibyo Supardi, Jerico F Pardosi, Sungwon Chang, Jon Adams
BACKGROUND: The level of traditional medicine use, particularly Jamu use, in Indonesia is substantial. Indonesians do not always seek timely treatment for malaria and may seek self-medication via traditional medicine. This paper reports findings from the first focused analyses of traditional medicine use for malaria in Indonesia and the first such analyses worldwide to draw upon a large sample of respondents across high-risk malaria endemic areas. METHODS: A sub-study of the Indonesia Basic Health Research/Riskesdas Study 2010 focused on 12,226 adults aged 15 years and above residing in high-risk malaria-endemic provinces...
2017: PloS One
https://www.readbyqxmd.com/read/28328491/the-age-of-opportunity-european-efforts-seek-to-address-the-challenges-of-an-aging-population-and-also-create-opportunities-for-economic-growth-and-innovation
#19
Jim Banks
For the last ten years, Peter Wintlev-Jensen has been immersed in one of the greatest challenges the world will have to address in the decades ahead-the unprecedented aging of the population not only in Europe but also across the globe. This trend is reshaping consumer spending, challenging established economic models, driving the development of new industry and service sectors, and forcing a rethinking of key policy areas within health and social care. To quantify the challenge from a U.K. perspective, a recent report from the nonprofit organization Age UK showed that the country now has more people 60 or over than under 18 and more pensioners than children under 16...
March 2017: IEEE Pulse
https://www.readbyqxmd.com/read/28326830/do-statin-users-adhere-to-a-healthy-diet-and-lifestyle-the-australian-diabetes-obesity-and-lifestyle-study
#20
Simran Johal, Kris M Jamsen, J Simon Bell, Kevin P Mc Namara, Dianna J Magliano, Danny Liew, Taliesin E Ryan-Atwood, Claire Anderson, Jenni Ilomäki
Background Lifestyle and dietary advice typically precedes or accompanies the prescription of statin medications. However, evidence for adherence to this advice is sparse. The objective was to compare saturated fat intake, exercise, alcohol consumption and smoking between statin users and non-users in Australia. Methods Data were analysed for 4614 participants aged ≥37 years in the Australian Diabetes, Obesity and Lifestyle study in 2011-2012. Statin use, smoking status and physical activity were self-reported...
April 2017: European Journal of Preventive Cardiology
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