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https://www.readbyqxmd.com/read/28545807/enhancing-erythritol-productivity-in-yarrowia-lipolytica-using-metabolic-engineering
#1
Frédéric Carly, Marie Vandermies, Samuel Telek, Sébastien Steels, Stéphane Thomas, Jean-Marc Nicaud, Patrick Fickers
Erythritol (1,2,3,4-butanetetrol) is a four-carbon sugar alcohol with sweetening properties that is used by the agrofood industry as a food additive. In this study, we demonstrated that metabolic engineering can be used to improve the production of erythritol from glycerol in the yeast Yarrowia lipolytica. The best results were obtained using a mutant that overexpressed GUT1 and TKL1, which encode a glycerol kinase and a transketolase, respectively, and in which EYK1, which encodes erythrulose kinase, was disrupted; the latter enzyme is involved in an early step of erythritol catabolism...
May 22, 2017: Metabolic Engineering
https://www.readbyqxmd.com/read/28545504/a-case-report-of-zinc-phosphide-poisoning-complicated-by-acute-renal-failure-and-tubulo-interstitial-nephritis
#2
Nilukshana Yogendranathan, H M M T B Herath, Thenuka Sivasundaram, R Constantine, Aruna Kulatunga
BACKGROUND: Run Rat® is a rodenticide widely used against small mammals. It comprises of a minimum of 32% zinc phosphide which is highly toxic in acute exposures to humans. It may be consumed accidentally or intentionally. It enters the body via skin, respiratory and gastrointestinal tracts. Zinc phosphide is hydrolyzed by the gastric acid and is transformed into phosphine gas. Phosphine is a respiratory toxin that inhibits cytochrome C oxidase system resulting in renal failure and liver failure...
May 25, 2017: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28545191/%C3%A2-mate%C3%A2-intake-hormone-based-risk-factors-and-breast-cancer-a-case-control-study
#3
Alvaro L Ronco, Edison Espinosa, Juan M Calderon, Eduardo Lasalvia- Galante, Alejandro De Rosa, Gustavo Sanchez
Previous reports on the inverse association between ‘mate’ intake (infusion of Ilex Paraguariensis herb) and breast cancer (BC) risk led us to consider two main roles for the infusion: as a substantial antioxidant contributor and as a hormone regulator, particularly through anti-aromatase capacities. Since menstrual-reproductive risk factors for BC reflect women’s estrogenic exposure during the reproductive lifespan, and considering that ‘mate’ intake exerts putative stronger protection among high antioxidant contributors, we attempted to analyze interactions among the infusion, hormon-linked reproductive factors and BC risk, which have hitherto remained unexplored...
April 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28545188/clinacanthus-nutans-hexane-extracts-induce-apoptosis-through-a-caspase-dependent-pathway-in-human-cancer-cell-lines
#4
Pei Ying Ng, Soi Moi Chye, Chew Hee Ng, Rhun Yian Koh, Yee Lian Tiong, Liew Phing Pui, Yong Hui Tan, Crystale Siew Ying Lim, Khuen Yen Ng
Background: Clinacanthus nutans (C.nutans) is a plant consumed as a cancer treatment in tropical Asia. Despite the availability of numerous anecdotal reports, evaluation of active anticancer effects has remained elusive. Therefore we here examined antiproliferative, reactive oxygen species (ROS)-inducing and apoptosis mechanisms of whole plant extracts in different cancer cell lines. Methods: Antiproliferative actions of five solvent extracts (hexane, chloroform, ethyl acetate, methanol and water) of C.nutans were tested on non-small cell lung cancer (A549), nasopharygeal cancer (CNE1) and liver cancer (HepG2) cells using MTT assay...
April 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28544415/inertial-microfluidic-cell-stretcher-imcs-fully-automated-high-throughput-and-near-real-time-cell-mechanotyping
#5
Yanxiang Deng, Steven P Davis, Fan Yang, Kevin S Paulsen, Maneesh Kumar, Rebecca Sinnott DeVaux, Xianhui Wang, Douglas S Conklin, Assad Oberai, Jason I Herschkowitz, Aram J Chung
Mechanical biomarkers associated with cytoskeletal structures have been reported as powerful label-free cell state identifiers. In order to measure cell mechanical properties, traditional biophysical (e.g., atomic force microscopy, micropipette aspiration, optical stretchers) and microfluidic approaches were mainly employed; however, they critically suffer from low-throughput, low-sensitivity, and/or time-consuming and labor-intensive processes, not allowing techniques to be practically used for cell biology research applications...
May 23, 2017: Small
https://www.readbyqxmd.com/read/28544204/receipt-and-use-of-spoken-and-written-over-the-counter-medicine-information-insights-into-australian-and-uk-consumers-experiences
#6
Vivien Tong, David K Raynor, Parisa Aslani
OBJECTIVES: To explore Australian and UK consumers' receipt and use of spoken and written medicine information and examine the role of leaflets for consumers of over-the-counter (OTC) medicines. METHODS: Semistructured interviews were conducted with 37 Australian and 39 UK consumers to explore information received with their most recent OTC medicine purchase, and how information was used at different times post-purchase. Interviews were audio-recorded, transcribed verbatim and thematically analysed...
May 24, 2017: International Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28544175/prevalence-and-potential-factors-associated-with-overweight-and-obesity-status-in-adults-with-intellectual-developmental-disorders
#7
REVIEW
Sobhana Ranjan, Jennifer A Nasser, Kathleen Fisher
BACKGROUND: The prevalence of being overweight and obese is increasing not just in the general population but also in individuals with intellectual disability (ID). Therefore, a need to identify factors contributing to overweight/obesity arises as this population is escalating. MATERIALS AND METHODS: This narrative review article summarizes pertinent research focusing on prevalence and the potential factors associated with overweight and obesity in adults with intellectual disability during the past decade...
May 24, 2017: Journal of Applied Research in Intellectual Disabilities: JARID
https://www.readbyqxmd.com/read/28544011/changing-trends-in-the-use-of-kratom-mitragyna-speciosa-in-southeast-asia
#8
Darshan Singh, Suresh Narayanan, Balasingam Vicknasingam, Ornella Corazza, Rita Santacroce, Andres Roman-Urrestarazu
OBJECTIVE: Kratom (Mitragyna speciosa. Korth) is an indigenous medicinal plant of Southeast Asia. This review paper aims to describe the trends of kratom use in Southeast Asia. DESIGN: A literature review search was conducted through ScienceDirect, Scopus, ProMed and Google Scholar. Twenty-five articles illustrating kratom use in humans in Southeast Asia were reviewed. RESULTS: Kratom has long been used by rural populations in Southeast Asia as a remedy for common ailments, to fight fatigue from hard manual work, as a drink during social interaction among men, and in village religious functions...
May 24, 2017: Human Psychopharmacology
https://www.readbyqxmd.com/read/28542901/mechanisms-and-implications-of-a-type-iv-functional-response-for-short-term-intake-rate-of-dry-matter-in-large-mammalian-herbivores
#9
J C Mezzalira, O J F Bonnet, P C de F Carvalho, L Fonseca, C Bremm, C C Mezzalira, E A Laca
1.The functional response (i.e. the relationship between consumers' intake rate and resource density) is central in plant-herbivore interactions. Its shape and the biological processes leading to it have significant implications for both foraging theory and ecology of grazing systems. 2.A type IV functional response (i.e. dome-shaped relationship) of short-term intake rate of dry matter (intake while grazing) has rarely been reported for large herbivores and the conditions that can lead to it are poorly understood...
May 19, 2017: Journal of Animal Ecology
https://www.readbyqxmd.com/read/28542445/dietary-cadmium-exposure-assessment-among-the-chinese-population
#10
Yan Song, Yibana Wang, Weifeng Mao, Haixia Sui, Ling Yong, Dajin Yang, Dingguo Jiang, Lei Zhang, Yunyun Gong
Cadmium, a toxic heavy metal, is widely present in food. It has been reported that chronic cadmium exposure is associated with kidney disease, osteoporosis, cardiovascular disease and cancer. The aim of this study was to assess the dietary cadmium exposure and potential health risk in different age-sex groups of the Chinese population (children aged 4-11 years, young people aged 12-17 years and adults aged over 18 years), and in the southern and northern population using a semi-probabilistic method. Cadmium was detected in 228,687 food samples from 32 food categrories by graphite furnace atomic absorption spectrometry...
2017: PloS One
https://www.readbyqxmd.com/read/28542242/-we-do-not-bury-dead-livestock-like-human-beings-community-behaviors-and-risk-of-rift-valley-fever-virus-infection-in-baringo-county-kenya
#11
Edna N Mutua, Salome A Bukachi, Bernard K Bett, Benson A Estambale, Isaac K Nyamongo
BACKGROUND: Rift Valley Fever (RVF), is a viral zoonotic disease transmitted by Aedes and Culex mosquitoes. In Kenya, its occurrence is associated with increased rains. In Baringo County, RVF was first reported in 2006 resulting in 85 human cases and 5 human deaths, besides livestock losses and livelihood disruptions. This study sought to investigate the county's current RVF risk status. METHODOLOGY AND PRINCIPAL FINDINGS: A cross-sectional study on the knowledge, attitudes and practices of RVF was conducted through a mixed methods approach utilizing a questionnaire survey (n = 560) and 26 focus group discussions (n = 231)...
May 24, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28541914/an-ultralow-power-sleep-spindle-detection-system-on-chip
#12
Saam Iranmanesh, Esther Rodriguez-Villegas
This paper describes a full system-on-chip to automatically detect sleep spindle events from scalp EEG signals. These events, which are known to play an important role on memory consolidation during sleep, are also characteristic of a number of neurological diseases. The operation of the system is based on a previously reported algorithm, which used the Teager energy operator, together with the Spectral Edge Frequency (SEF50) achieving more than 70% sensitivity and 98% specificity. The algorithm is now converted into a hardware analog based customized implementation in order to achieve extremely low levels of power...
May 24, 2017: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/28541823/emission-factors-of-fine-particulate-matter-organic-and-elemental-carbon-carbon-monoxide-and-carbon-dioxide-for-four-solid-fuels-commonly-used-in-residential-heating-by-the-navajo-nation
#13
Wyatt M Champion, Lea Connors, Lupita D Montoya
Most homes in the Navajo Nation use wood as their primary heating fuel, often in combination with locally-mined coal. Previous studies observed health effects linked to this solid-fuel use in several Navajo communities. Emission factors (EF) for common fuels used by the Navajo have not been reported using a relevant stove type. In this study, two softwoods (Ponderosa Pine and Utah Juniper) and two high-volatile bituminous coals (Black Mesa and Fruitland) were tested with an in-use residential conventional wood stove (homestove) using a modified ASTM/EPA protocol...
May 25, 2017: Journal of the Air & Waste Management Association
https://www.readbyqxmd.com/read/28541798/intergenerational-care-an-exploration-of-consumefr-preferences-and-willingness-to-pay-for-care
#14
N Vecchio, K Radford, J A Fitzgerald, T Comans, P Harris, N Harris
OBJECTIVES: To identify feasible models of intergenerational care programmes, that is, care of children and older people in a shared setting, to determine consumer preferences and willingness to pay. METHOD: Feasible models were constructed in extensive consultations with a panel of experts using a Delphi technique (n = 23) and were considered based on their practical implementation within an Australian setting. This informed a survey tool that captured the preferences and willingness to pay for these models by potential consumers, when compared to the status quo...
May 25, 2017: Aging & Mental Health
https://www.readbyqxmd.com/read/28541430/implementation-and-evaluation-of-a-prototype-consumer-reporting-system-for-patient-safety-events
#15
Saul N Weingart, Joel S Weissman, Karen P Zimmer, Robert C Giannini, Denise D Quigley, Lauren E Hunter, M Susan Ridgely, Eric C Schneider
Objective: No methodologically robust system exists for capturing consumer-generated patient safety reports. To address this challenge, we developed and pilot-tested a prototype consumer reporting system for patient safety, the Health Care Safety Hotline. Design: Mixed methods evaluation. Setting: The Hotline was implemented in two US healthcare systems from 1 February 2014 through 30 June 2015. Participants: Patients, family members and caregivers associated with two US healthcare systems...
May 24, 2017: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/28539908/a-walk-on-the-wild-side-the-impact-of-music-on-risk-taking-likelihood
#16
Rickard Enström, Rodney Schmaltz
From a marketing perspective, there has been substantial interest in on the role of risk-perception on consumer behavior. Specific 'problem music' like rap and heavy metal has long been associated with delinquent behavior, including violence, drug use, and promiscuous sex. Although individuals' risk preferences have been investigated across a range of decision-making situations, there has been little empirical work demonstrating the direct role music may have on the likelihood of engaging in risky activities...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28539686/lifecourse-transitions-gender-and-drinking-in-later-life
#17
Clare Holdsworth, Martin Frisher, Marina Mendonça, Cesar DE Oliveiria, Hynek Pikhart, Nicola Shelton
Older people consume less alcohol than any other adult age group. However, in recent years survey data on alcohol consumption in the United Kingdom have shown that while younger age groups have experienced a decline in alcohol consumption, drinking behaviours among the elderly have not reduced in the same way. This paper uses data from the English Longitudinal Study of Ageing to analyse both the frequency and quantity of older adult's alcohol consumption using a lifecourse approach over a ten-year period. Overall drinking declined over time and the analysis examined how socio-economic characteristics, partnership, employment and health statuses were associated with differences in drinking behaviours and how these changed over time...
March 2017: Ageing and Society
https://www.readbyqxmd.com/read/28539674/nutrition-label-experience-and-consumption-of-transitional-foods-among-a-nationwide-cohort-of-42-750-thai-adults
#18
Wimalin Rimpeekool, Martyn Kirk, Vasoontara Yiengprugsawan, Cathy Banwell, Sam-Ang Seubsman, Adrian Sleigh
PURPOSE: The purpose of this paper is to assess the usefulness of nutrition labels in Thailand during nutrition transition from traditional to modern diets that increase salt, sugar, and calorie intake and to note socio-demographic interactions and associations with consumption of transitional processed foods. DESIGN/METHODOLOGY/APPROACH: The authors studied 42,750 distance learning Open University adults aged 23-96 years in 2013 residing nationwide and participating in an ongoing community-based prospective cohort study...
2017: Br Food J
https://www.readbyqxmd.com/read/28539344/investigation-of-kingella-kingae-invasive-infections-outbreaks-in-day-care-facilities-assessment-of-a-rapid-genotyping-tool-targeting-the-dna-uptake-sequence
#19
Philippe Bidet, Violaine Tran Quang, Pablo Yagusky, André Birgy, Stéphane Bonacorsi, Romain Basmaci
Objectives Outbreaks of Kingella kingae invasive infections have recently been reported in day-care centers. Pulsed-field gel electrophoresis (PFGE) and multilocus sequence typing (MLST) revealed that although the invasive strains had a widespread dissemination in the day-care population, less virulent strains were also found to be circulating in the facility. However, these typing tools are costly, time-consuming and labor-intensive, and provide delayed results. A study was conducted to assess the performance of a rapid and cost-effective genotyping tool targeting the DNA uptake sequence (DUS) in the investigation of outbreaks of K...
May 24, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28538708/accuracy-in-wrist-worn-sensor-based-measurements-of-heart-rate-and-energy-expenditure-in-a-diverse-cohort
#20
Anna Shcherbina, C Mikael Mattsson, Daryl Waggott, Heidi Salisbury, Jeffrey W Christle, Trevor Hastie, Matthew T Wheeler, Euan A Ashley
The ability to measure physical activity through wrist-worn devices provides an opportunity for cardiovascular medicine. However, the accuracy of commercial devices is largely unknown. The aim of this work is to assess the accuracy of seven commercially available wrist-worn devices in estimating heart rate (HR) and energy expenditure (EE) and to propose a wearable sensor evaluation framework. We evaluated the Apple Watch, Basis Peak, Fitbit Surge, Microsoft Band, Mio Alpha 2, PulseOn, and Samsung Gear S2. Participants wore devices while being simultaneously assessed with continuous telemetry and indirect calorimetry while sitting, walking, running, and cycling...
May 24, 2017: Journal of Personalized Medicine
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