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Black salve

Andrew Croaker, Graham J King, John H Pyne, Shailendra Anoopkumar-Dukie, Lei Liu
Epidemic dropsy is a potentially life-threatening condition resulting from the ingestion of argemone oil derived from the seeds of Argemone mexicana Linn. Exposure to argemone oil is usually inadvertent, arising from mustard cooking oil adulteration. Sanguinarine, an alkaloid present in argemone oil, has been postulated as a causative agent with the severity of epidemic dropsy correlating with plasma sanguinarine levels. Cases of epidemic dropsy have also been reported following the topical application of argemone containing massage oil...
March 30, 2018: Journal of Applied Toxicology: JAT
Andrew Croaker, Graham J King, John H Pyne, Shailendra Anoopkumar-Dukie, Vilim Simanek, Lei Liu
Black salves are escharotic skin cancer therapies in clinical use since the mid 19th century. Sanguinaria canadensis, a major ingredient of black salve formulations, contains a number of bioactive phytochemicals including the alkaloid sanguinarine. Despite its prolonged history of clinical use, conflicting experimental results have prevented the carcinogenic potential of sanguinarine from being definitively determined. Sanguinarine has a molecular structure similar to known polyaromatic hydrocarbon carcinogens and is a DNA intercalator...
October 2017: Mutation Research
Alvin Lim
The use of complementary and alternative medicines in Australia has grown significantly. Much of this growth is due to their ease of accessibility from online vendors, often marketed with claims that are not scientifically tested. Black salve is a topical escharotic compound containing the active component sanguinarine, derived from the bloodroot plant. It has been advertised as a natural treatment for skin cancer. This article reviews the current state of black salve as an alternative skin cancer treatment, discussing its distribution and regulation, and provides a summary of clinical and laboratory studies...
November 3, 2017: Journal of Dermatological Treatment
Dayne Laskey, Midori Tran
A previously healthy 86-year-old male was transported by ambulance to the trauma bay of the emergency department (ED) for profuse bleeding from the left temple. The ambulance crew raised concern that the volume and force of the bleed may suggest arterial involvement. The patient reported having applied a natural topical remedy to a mole two weeks prior at the recommendation of a naturopath. The patient described progressive blackening and swelling of the area in the days following the single application of the product...
August 2017: Clinical Toxicology
Andrew Croaker, Graham J King, John H Pyne, Shailendra Anoopkumar-Dukie, Lei Liu
Black salve is a topical escharotic used for the treatment of skin cancer. Although promoted as a safe and effective alternative to conventional management by its proponents, limited clinical research has been undertaken to assess its efficacy and potential toxicities. Patients are increasingly utilizing the Internet as a source of health information. As a minimally regulated space, the quality and accuracy of this information vary considerably. This review explores four health claims made by black salve vendors, investigating its natural therapy credentials, tumour specificity, and equivalence to orthodox medicine in relation to skin cancer cure rates and cosmesis...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
Joshua J Clark, Alexandra Woodcock, Sarah D Cipriano, Mark A Hyde, Sandra L Edwards, Caren J Frost, Mark J Eliason
No abstract text is available yet for this article.
May 2016: Journal of the American Academy of Dermatology
Jennifer L Hou, Jerry D Brewer
Due to extensive advertising of black salve's effectiveness in "curing" skin cancers and healing other skin conditions, many patients are turning to self-treating with black salve. Although black salve has not been proven to have anticancer properties, application of black salve has been shown to cause damage to healthy tissue and the need for further treatment. We describe a 35-year-old woman whose one-time application of black salve to a healing biopsy site resulted in skin erosion and formation of a dermatitic plaque with subsequent scarring...
June 2015: Cutis; Cutaneous Medicine for the Practitioner
Graham W Sivyer, Cliff Rosendahl
This is a case study of a female patient diagnosed with superficial spreading melanoma who decided to treat the lesion by the application of a preparation known as black salve. Persistence of the melanoma was documented five years later with subsequent evidence of metastatic spread to the regional lymph nodes, lungs, liver, subcutaneous tissues and musculature. A literature search has revealed one other case study of the use of black salve for the treatment of melanoma.
July 2014: Dermatology Practical & Conceptual
Kristin L Eastman, Lynne V McFarland, Gregory J Raugi
Black salve is a compound derived from various inert ingredients, but it can be transformed into a corrosive ointment by the addition of bloodroot (Sanguinaria canadensis) or zinc chloride. Black salve products have been advertised as a natural remedy for many ailments, ranging from bee stings to skin cancer. This article reviews the current literature surrounding this compound, which in its corrosive form can be dangerous for use without medical supervision. Patients should be educated about the lack of objective evidence supporting the clinical efficacy of black salve as a skin cancer treatment, as well as the possible cosmetic defects resulting from tissue necrosis secondary to the effects of bloodroot and zinc chloride...
April 2014: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
Tamazin N Leecy, Trevor W Beer, Nathan T Harvey, S Prasad Kumarasinghe, Dugald McCallum, Lawrence L Yu, Benjamin A Wood
AIMS: To document the histopathological features of self-treatment of cutaneous lesions with the escharotic agent black salve. METHODS: Retrospective review of cutaneous lesions treated with black salve retrieved from the files of four pathology practices in Western Australia and review of the published literature. RESULTS: 16 lesions from 11 patients who self administered black salve for the treatment of skin lesions were reviewed. Clinical diagnoses at the time of biopsy included scar, keloid scar, pseudomelanoma, basal cell carcinoma, squamous cell carcinoma and cutaneous necrosis...
December 2013: Pathology
Liqiao Ma, Jennifer Warner Dharamsi, Travis Vandergriff
No abstract text is available yet for this article.
September 2012: Dermatitis
John J Cienki, Larry Zaret
INTRODUCTION: Bloodroot (Sanguinaria canadensis) is a perennial flowering plant native to North America. Sanguinarine, a benzylisoquinoline alkaloid, is a powerful escharotic contained in the root. Herbalists prescribe bloodroot for multiple conditions including skin lesions and sore throats. We report 2 patients who treated skin lesions with bloodroot to untoward effect. CASE REPORT 1: A 53-year-old man with unremarkable medical history developed a 5-mm papule on his chest that gradually blackened...
October 2010: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
Felicia Saltzberg, Gregory Barron, Neil Fenske
No abstract text is available yet for this article.
July 2009: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
Sandra S Osswald, Dirk M Elston, Mary F Farley, John G Alberti, Steven C Cordero, Victor F Kalasinsky
Patients may seek "alternative" or "non-traditional" therapies for dermatologic problems, frequently in search of a miraculous cure. However, many of these medicaments contain unknown compounds with questionable benefit and a potential for significant harm. We describe a patient who developed a large ulceration on her nose after applying "black and yellow salves" obtained from Mexico in an attempt to self-treat a basal cell carcinoma.
September 2005: Journal of the American Academy of Dermatology
Genady G Matishov, Dimitry G Matishov, Alexey A Namjatov, JoLynn Carroll, Salve Dahle
The Don River Estuary-Azov Sea system is an extension of the shallow continental shelf area of the Black Sea. A large data set of artificial radionuclides in bottom sediments of the Azov Sea has been compiled in order to examine the storage and migration of radionuclides within this highly restricted inland sea and to estimate the annual dose received by individuals in the local population who regularly consume fish. In recent years (1997-1999), the radionuclide content of surface sediments has been: 137Cs < or = 0...
2002: Journal of Environmental Radioactivity
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