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https://www.readbyqxmd.com/read/29127818/cytokinesis-block-micronucleus-cytome-assay-parameters-in-peripheral-blood-lymphocytes-of-the-general-population-contribution-of-age-sex-seasonal-variations-and-lifestyle-factors
#1
Goran Gajski, Marko Gerić, Višnja Oreščanin, Vera Garaj-Vrhovac
The cytokinesis-block micronucleus cytome (CBMN Cyt) assay was used to evaluate the baseline frequency of cytogenetic damage in peripheral blood lymphocytes of the general population (average age, 38.28 ± 12.83 years) in relation to age, sex, body mass index, seasonal variations (season of sampling, period of sampling and different meteorological parameters) and lifestyle factors (smoking habit, alcohol consumption, exposure to medications and diagnostic radiation, physical activity, and family history of cancer)...
November 8, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29101750/adaptation-of-small-mammals-to-radiocontaminated-environment-oxidative-metabolism-and-radioresistance
#2
L N Rasina, E B Grigorkina, N A Orekhova
Differences in radioresistance and oxidative metabolism parameters in rodents of different ecological specialization in the East Ural radioactive trace (EURT) area are shown. Northern mole voles (radiosensitive species) exhibit a pronounced resistance to chronic exposure to radiation, living in a series of generations in a radioactive environment, whereas pigmy wood mice (radioresistant species) are less resistant in the EURT area due to their migration activity. Thus, under the EURT area conditions, northern mole voles realize the genotypic radioadaptation, whereas pigmy wood mice realize the physiological radioadaptation, the key role in which is played by the ecological and physiological characteristics and the lifestyle of animals...
September 2017: Doklady. Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29076965/mutational-and-epigenetic-signatures-in-cancer-tissue-linked-to-environmental-exposures-and-lifestyle
#3
Vittorio Perduca, Hanane Omichessan, Laura Baglietto, Gianluca Severi
PURPOSE OF REVIEW: In this article, we describe how recent advances in the study of mutational and epigenetic signatures in tumours provide new opportunities to understand the role of the environment and lifestyle in cancer development. RECENT FINDINGS: Cancer-related mutational events have been investigated for decades but only recently the wide availability of genomic sequences and epigenomic data from thousands of cancer genomes has made it possible to identify numerous distinct mutational and epigenetic signatures through the application of advanced mathematical models...
October 25, 2017: Current Opinion in Oncology
https://www.readbyqxmd.com/read/28993654/ctenophore-relationships-and-their-placement-as-the-sister-group-to-all-other-animals
#4
Nathan V Whelan, Kevin M Kocot, Tatiana P Moroz, Krishanu Mukherjee, Peter Williams, Gustav Paulay, Leonid L Moroz, Kenneth M Halanych
Ctenophora, comprising approximately 200 described species, is an important lineage for understanding metazoan evolution and is of great ecological and economic importance. Ctenophore diversity includes species with unique colloblasts used for prey capture, smooth and striated muscles, benthic and pelagic lifestyles, and locomotion with ciliated paddles or muscular propulsion. However, the ancestral states of traits are debated and relationships among many lineages are unresolved. Here, using 27 newly sequenced ctenophore transcriptomes, publicly available data and methods to control systematic error, we establish the placement of Ctenophora as the sister group to all other animals and refine the phylogenetic relationships within ctenophores...
November 2017: Nature ecology & evolution
https://www.readbyqxmd.com/read/28989763/into-the-dark-patterns-of-middle-ear-adaptations-in-subterranean-eulipotyphlan-mammals
#5
Daisuke Koyabu, Misato Hosojima, Hideki Endo
Evolution of the middle ear ossicles was a key innovation for mammals, enhancing the transmission of airborne sound. Radiation into various habitats from a terrestrial environment resulted in diversification of the auditory mechanisms among mammals. However, due to the paucity of phylogenetically controlled investigations, how middle ear traits have diversified with functional specialization remains unclear. In order to identify the respective patterns for various lifestyles and to gain insights into fossil forms, we employed a high-resolution tomography technique and compared the middle ear morphology of eulipotyphlan species (moles, shrews and hedgehogs), a group that has radiated into various environments, such as terrestrial, aquatic and subterranean habitats...
September 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28983918/how-many-cancer-cases-and-deaths-are-potentially-preventable-estimates-for-australia-in-2013
#6
Louise F Wilson, Annika Antonsson, Adele C Green, Susan J Jordan, Bradley J Kendall, Christina M Nagle, Rachel E Neale, Catherine M Olsen, Penelope M Webb, David C Whiteman
Cancer is a leading cause of disease burden in Australia, particularly fatal burden, accounting for an estimated thirty percent of deaths. Many cancers develop because of exposure to lifestyle and environmental factors that are potentially modifiable. We aimed to quantify the proportions and numbers of cancer deaths and cases in Australia in 2013 attributable to 20 modifiable factors in eight broad groupings that are established causes of cancer, namely: tobacco smoke (smoking and second-hand), dietary factors (low intake of fruit, non-starchy vegetables and dietary fibre; and high intake of red and processed meat), overweight/obesity, alcohol, physical inactivity, solar ultraviolet radiation, infections (seven agents), and reproductive factors (lack of breastfeeding, menopausal hormone therapy use, combined oral contraceptive use)...
October 6, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28977647/attributable-risk-fraction-of-four-lifestyle-risk-factors-of-thyroid-cancer-a-meta-analysis
#7
Hajar Sadeghi, Mohammad Rafei, Masoud Bahrami, AliAkbar Haghdoost, Yazdan Shabani
Background: Lifestyle risk factors such as obesity, overweight, smoking and radiation exposure related to thyroid cancer. This study estimated the amount of excess risk that attributed to risk factors. Methods: Major electronic databases were searched until February 2016. Epidemiological studies addressing the association between lifestyle risk factors and thyroid cancer were enrolled. The results were expressed as ARF with 95% confidence intervals (CIs) using a random-effects-model...
August 9, 2017: Journal of Public Health
https://www.readbyqxmd.com/read/28973710/breast-cancer-survivorship-patient-characteristics-and-plans-for-high-quality-care
#8
REVIEW
Loretta S Loftus, Gerald H Sokol, Christine Laronga
The number of breast cancer survivors has increased and this increase is expected to continue, likely as a result of population and age growth, the implementation of earlier detection strategies, and the development of more effective therapies. Breast cancer treatment requires a multidisciplinary approach with surgery, radiation, chemotherapy, targeted therapy, and hormonal therapy. Breast cancer survivors may develop various long-term adverse effects from these therapies. Care of the survivor may transition eventually to the primary care physician...
October 2017: Southern Medical Journal
https://www.readbyqxmd.com/read/28957385/additional-risk-of-diabetes-exceeds-the-increased-risk-of-cancer-caused-by-radiation-exposure-after-the-fukushima-disaster
#9
Michio Murakami, Masaharu Tsubokura, Kyoko Ono, Shuhei Nomura, Tomoyoshi Oikawa
The 2011 Fukushima disaster led to increases in multiple risks (e.g., lifestyle diseases and radiation exposure) and fear among the public. Here, we assessed the additional risks of cancer caused by radiation and diabetes related to the disaster and the cost-effectiveness of countermeasures against these conditions. Our study included residents of the cities of Minamisoma and Soma (10-40 km and 35-50 km north of the Fukushima Daiichi (N° 1) Nuclear Power Station, respectively). We used the loss of life expectancy (LLE) as an indicator to compare risks between radiation exposure and diabetes...
2017: PloS One
https://www.readbyqxmd.com/read/28954497/knowledge-on-neoplastic-diseases-among-young-rural-inhabitants
#10
Anna Lewandowska, Rafał Filip
OBJECTIVE: The objective of the study was to analyze the level of knowledge on tumours and their prevention among rural inhabitants. MATERIAL AND METHODS: The research involved 500 residents of villages in Podkarpackie Province in south-east Poland. The age of the researched ranges from 18-30 years; mean age - 26.96±0.84 (range [18, 30], median 25.95%CI [18, 9, 29, 01]). The researched group was represented in 47.59% by women in 52.41% by men. In order to obtain the research material, a standardized questionnaire was applied which included questions focused mainly on assessment of the level of knowledge on tumours (causes, symptoms, ways of treatment, prevention), as well as questions with both spontaneous and prompted answers...
September 21, 2017: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/28935893/trap-diversity-and-character-evolution-in-carnivorous-bladderworts-utricularia-lentibulariaceae
#11
Anna Sofia Westermeier, Andreas Fleischmann, Kai Müller, Bastian Schäferhoff, Carmen Rubach, Thomas Speck, Simon Poppinga
Bladderworts (Utricularia, Lentibulariaceae, Lamiales) constitute the largest genus of carnivorous plants but only aquatic species (about one fifth of the genus) have so far been thoroughly studied as to their suction trap functioning. In this study, we comparatively investigated trap biomechanics in 19 Utricularia species to examine correlations between life-forms, trapping mechanisms, and functional-morphological traits. Our investigations show the existence of two functional trap principles (passive trap in U...
September 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28905483/lung-cancer-in-young-women-in-southern-sweden-a-descriptive-study
#12
Ildikó Fritz, Håkan Olsson
INTRODUCTION: Lung cancer, a common malignancy and cause of cancer-related deaths, is strongly linked to several environmental exposures, and thus primarily affects the elderly. Formerly a man's disease, its incidence is rising among women, and lung cancer is now more common in women than men in Sweden. Women are particularly over-represented among young patients. While overall cancer mortality in Europe is decreasing, female lung cancer mortality is increasing. OBJECTIVES: We describe the epidemiological presentation of lung cancer in young Swedish women, aiming to pinpoint its risk factors for young women...
September 14, 2017: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/28894712/evaluation-of-the-level-of-zinc-and-malondialdehyde-in-basal-cell-carcinoma
#13
Ziba Majidi, Mahmoud Djalali, Mohammad Hasan Javanbakht, Mojtaba Fathi, Mahnaz Zarei, Koorosh Foladsaz
BACKGROUND: Basal Cell Carcinoma (BCC) is one of the most common skin cancers in the world and that use to lifestyle, increasing chemical pollutions, environmental factors and poor nutrition. The most important cause of this cancer is oxidative stress and free radicals so antioxidant activities for the body are so important. The aim of this study was to determine the variation of zinc and (Malondialdehyde) MDA in BCC patients. METHODS: This study has been performed on case and control patients from 2013 to 2014...
August 2017: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/28876555/an-overview-of-risk-factors-for-recurrent-breast-cancer
#14
A Mannell
The multidisciplinary management of Breast Cancer (BC) has evolved over the past 50 years: the patient is offered a choice of surgical procedures with or without radiation therapy, cytotoxics and treatments targeting the nuclei of the cancer cells. This has resulted in a reduction of disease recurrence and a significant increase in 5-year survival. But these good results deteriorate over time and almost 20% women with early stage, oestrogen-receptor (ER) positive BC will suffer recurrent cancer at 10 years...
March 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/28821245/ambient-ultraviolet-radiation-exposure-and-hepatocellular-carcinoma-incidence-in-the-united-states
#15
Trang VoPham, Kimberly A Bertrand, Jian-Min Yuan, Rulla M Tamimi, Jaime E Hart, Francine Laden
BACKGROUND: Hepatocellular carcinoma (HCC), the most commonly occurring type of primary liver cancer, has been increasing in incidence worldwide. Vitamin D, acquired from sunlight exposure, diet, and dietary supplements, has been hypothesized to impact hepatocarcinogenesis. However, previous epidemiologic studies examining the associations between dietary and serum vitamin D reported mixed results. The purpose of this study was to examine the association between ambient ultraviolet (UV) radiation exposure and HCC risk in the U...
August 18, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/28794393/preventive-measures-and-lifestyle-habits-against-exertional-heat-illness-in-radiation-decontamination-workers
#16
Shota Endo, Takeyasu Kakamu, Sei Sato, Tomoo Hidaka, Tomohiro Kumagai, Shinichi Nakano, Kikuo Koyama, Tetsuhito Fukushima
OBJECTIVES: The aim of this study was to reveal the current state of preventive measures and lifestyle habits against heat illness in radiation decontamination workers and to examine whether young radiation decontamination workers take less preventive measures and have worse lifestyle habits than the elder workers. METHODS: This was a cross-sectional study. Self-administered questionnaires were sent to 1,505 radiation decontamination workers in Fukushima, Japan...
September 28, 2017: Journal of Occupational Health
https://www.readbyqxmd.com/read/28732778/functional-analysis-of-the-mapk-pathways-in-fungi
#17
Domingo Martínez-Soto, José Ruiz-Herrera
The Mitogen-Activated Protein Kinase (MAPK) signaling pathways constitute one of the most important and evolutionarily conserved mechanisms for the perception of extracellular information in all the eukaryotic organisms. The MAPK pathways are involved in the transfer to the cell of the information perceived from extracellular stimuli, with the final outcome of activation of different transcription factors that regulate gene expression in response to them. In all species of fungi, the MAPK pathways have important roles in their physiology and development; e...
July 18, 2017: Revista Iberoamericana de Micología
https://www.readbyqxmd.com/read/28707205/knowledge-and-preferences-of-primary-care-providers-in-delivering-head-and-neck-cancer-survivorship-care
#18
Callie Berkowitz, Deborah H Allen, Jennifer Tenhover, Leah L Zullig, John Ragsdale, Jonathan E Fischer, Kathryn I Pollak, Bridget F Koontz
Long-term care for head and neck cancer (HNC) survivors is complex and requires coordination among multiple providers. Clinical practice guidelines highlight the role of primary care providers (PCPs) in screening for secondary cancer/recurrence, assessment of late/long-term side effects, and referrals for appropriate specialty management of toxicity. However, these responsibilities may be difficult to meet within the scope of primary care practice. We conducted this study to explore preferences, comfort, and knowledge of PCPs in the care of HNC survivors...
July 14, 2017: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/28705931/proof-of-concept-design-and-initial-evaluation-of-a-new-device-to-measure-gastrointestinal-transit-time
#19
Robert H Wagner, Bital Savir-Baruch, James Halama, Mukund Venu, Medhat Gabriel, Davide Bova
Chronic constipation and gastrointestinal motility disorders constitute a large part of a gastroenterology practice and represent a significant impact on patient quality of life and lifestyle. In most cases, medications are prescribed to alleviate symptoms without an objective measurement of response. Commonly used current investigations of gastrointestinal transit times are limited to radiopaque markers or electronic capsules. Repeated use of these techniques is limited due to radiation exposure or the significant cost of the devices...
July 13, 2017: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/28692406/mortality-from-circulatory-diseases-and-other-non-cancer-outcomes-among-nuclear-workers-in-france-the-united-kingdom-and-the-united-states-inworks
#20
COMPARATIVE STUDY
Michael Gillies, David B Richardson, Elisabeth Cardis, Robert D Daniels, Jacqueline A O'Hagan, Richard Haylock, Dominique Laurier, Klervi Leuraud, Monika Moissonnier, Mary K Schubauer-Berigan, Isabelle Thierry-Chef, Ausrele Kesminiene
Positive associations between external radiation dose and non-cancer mortality have been found in a number of published studies, primarily of populations exposed to high-dose, high-dose-rate ionizing radiation. The goal of this study was to determine whether external radiation dose was associated with non-cancer mortality in a large pooled cohort of nuclear workers exposed to low-dose radiation accumulated at low dose rates. The cohort comprised 308,297 workers from France, United Kingdom and United States...
September 2017: Radiation Research
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