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gastric intestinal metaplasia

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https://www.readbyqxmd.com/read/28918609/associations-among-gastric-juice-ph-atrophic-gastritis-intestinal-metaplasia-and-helicobacter-pylori-infection
#1
Jihee Sung, Nayoung Kim, Jongchan Lee, Young-Jae Hwang, Hyoung Woo Kim, Jung Wha Chung, Jin-Wook Kim, Dong Ho Lee
Background/Aims: Gastric juice plays a crucial role in the physiology of the stomach. The aim of this study is to evaluate associations among the pH of gastric juice, atrophic gastritis (AG), intestinal metaplasia (IM), pepsinogen, and Helicobacter pylori infection. Methods: Gastric biopsies and juice were collected from 46 subjects who underwent endoscopies at Seoul National University Bundang Hospital between November 2011 and March 2013. H. pylori, AG and IM were evaluated, and pepsinogen I or II, I/II ratio and interleukin (IL)-1β levels were measured...
September 19, 2017: Gut and Liver
https://www.readbyqxmd.com/read/28905803/diagnosis-and-treatment-of-gastroesophageal-reflux-disease-complicated-by-barrett-s-esophagus
#2
Andriy Stasyshyn
The aim of the study was to evaluate the effectiveness of a diagnostic and therapeutic algorithm for gastroesophageal reflux disease complicated by Barrett's esophagus in 46 patients. MATERIALS AND METHODS: A diagnostic and therapeutic algorithm for complicated GERD was developed. To describe the changes in the esophagus with reflux esophagitis, the Los Angeles classification was used. Intestinal metaplasia of the epithelium in the lower third of the esophagus was assessed using videoendoscopy, chromoscopy, and biopsy...
August 31, 2017: Polski Przeglad Chirurgiczny
https://www.readbyqxmd.com/read/28903902/single-cell-gene-variation-analysis-method-for-single-gland
#3
Yan Zhou, Chao-Jie Wang, Chun-Chao Zhu, Jiang-Rong Chen, Ming Cheng, Yu-Liang Deng, Yan Guo
Single-cell analysis of heterogeneity has become the cutting-edge technology for profound understandings of relationships between cell populations. At present, common methods used in single cellular genomic research are mainly microfluidic technologies (Fluidigm) or based on microwells, both requiring a uniform size of cells at the entrance. However, the size of cells in specific tissues can vary from type to type. To address this issue, we need to establish a method to identify genomic features of individual cells of different sizes...
August 20, 2017: Yi Chuan, Hereditas
https://www.readbyqxmd.com/read/28893301/intussusception-caused-by-heterotopic-gastric-mucosa-in-small-intestine-a-case-report
#4
Priyanka Anand, Sompal Singh, Namrata Sarin
BACKGROUND: Intestinal intussusception is the most frequent cause of small bowel obstruction in children between the ages of 2 months and 5 years and often remains idiopathic in etiology, even after surgery. On microscopic examination, in intussusception normal mucosa is noted but in a few cases heterotopic tissue can be seen. Heterotopic gastric mucosa in the small intestine is extremely rare except for its occurrence in remnants of Meckel's diverticulum. In view of the rarity of this condition, we report a case of ectopic gastric mucosa in the small intestine that was not associated with remnants of vitelline duct...
September 12, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28891127/helicobacter-pylori-gastric-cancer-and-other-gastrointestinal-malignancies
#5
REVIEW
Marino Venerito, Riccardo Vasapolli, Theodore Rokkas, Jean-Charles Delchier, Peter Malfertheiner
In a retrospective study performed in California, U.S.A., ca. 3% of patients with gastric intestinal metaplasia (GIM) developed gastric cancer (GC) within a median time period of 4.6 years after diagnosis of GIM. This observation stresses the importance of targeted surveillance even in regions with a low GC prevalence. Patients with alcoholic liver disease as well as survivors of colorectal and lobular breast cancer were found to be at increased risk of secondary GC. A population-based Chinese study confirmed "serologic biopsy" as a useful screening tool for stratifying the individual risk of developing GC...
September 2017: Helicobacter
https://www.readbyqxmd.com/read/28889157/epidemiologic-characteristics-of-gastric-malignancies-among-jordan-university-hospital-patients
#6
Heyam A Awad, Manar H Hajeer, Mohand W Abulihya, Mohammad A Al-Chalabi, Ali A Al Khader
To discover the epidemiologic distribution of gastric malignancies among Jordan University Hospital patients and to compare this distribution with the neighboring Arab countries. Methods: Retrospective study covering the period between  January 2006, and May 2016, in Jordan University Hospital, Amman, Jordan. All cases were retrieved from the computer system and analyzed using IBM SPSS version 23 software.  Results: One hundred and sixty-five cases were analyzed. Male-to-female ratio was 1.2:1. The mean age was 58...
September 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/28886101/high-prevalence-of-gastric-intestinal-metaplasia-detected-by-confocal-laser-endomicroscopy-in-zambian-adults
#7
Violet Kayamba, Aaron Shibemba, Kanekwa Zyambo, Douglas C Heimburger, Douglas R Morgan, Paul Kelly
BACKGROUND: Confocal laser endomicroscopy (CLE) may increase the detection of gastric premalignant lesions, and facilitate targeted biopsies for histology. The study aim was to analyse premalignant lesions in Zambian adults using CLE. METHODS: Using CLE and histology we analysed the antral mucosa for gastric premalignant lesions in asymptomatic adults living with HIV and in HIV seronegative adults. Fasting gastric pH and the presence of Helicobacter pylori (H. pylori) were also evaluated...
2017: PloS One
https://www.readbyqxmd.com/read/28881583/troy-is-expressed-in-human-stomach-mucosa-and-a-novel-putative-prognostic-marker-of-intestinal-type-gastric-cancer
#8
Franziska Wilhelm, Christine Böger, Sandra Krüger, Hans-Michael Behrens, Christoph Röcken
Epithelial stem cells of gastrointestinal tissues are characterized and controlled by an active Wnt signaling. Recently, the Wnt target gene Troy has been proposed as a neoplastic marker in the murine intestine. In this study, we explored the putative tumor biological significance of Troy in humans by using immunohistochemistry (104 cases), quantitative RT-PCR (50 cases) and cell culture experiments (MKN45, MKN74). In the non-neoplastic gastric mucosa, Troy was expressed by Muc5AC-positive foveolar epithelium, parietal cells, chief cells and cells of the intestinal metaplasia...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28877809/a-review-of-sleeve-gastrectomy-specimen-histopathology
#9
Luke A Kinsinger, James C Garber, Oliver Whipple
With the increasing popularity of sleeve gastrectomy, many stomach specimens are being evaluated. Understanding the significance and treatment for unexpected pathology is important. This study examines the incidence of relevant histopathology of sleeve gastrectomy specimens. It evaluates previous data for each histopathology and provides recommendations for treatment. In this study, a retrospective review was performed for 241 patients who underwent sleeve gastrectomy from 2009 to 2014 at a single institution...
November 1, 2016: American Surgeon
https://www.readbyqxmd.com/read/28868113/gastric-xanthoma-is-a-predictive-marker-for-metachronous-and-synchronous-gastric-cancer
#10
Narihiro Shibukawa, Shohei Ouchi, Shuji Wakamatsu, Yuhei Wakahara, Akira Kaneko
AIM: To investigate predictive markers for metachronous and synchronous gastric cancer (GC), which can develop after endoscopic submucosal dissection (ESD). METHODS: A total of 352 patients underwent ESD for early GC at NTT West Osaka Hospital between June 2006 and February 2016. Exclusion criteria were as follows: Remnant stomach, unknown Helicobacter pylori status, and endoscopic observation of the whole stomach outside our hospital. We analyzed data from 192 patients comprising 109 patients with solitary GC (Group A) and 83 with metachronous and synchronous GC (Group B)...
August 15, 2017: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28839434/pbx1-attributes-as-a-determinant-of-connexin-32-downregulation-in-helicobacter-pylori-related-gastric-carcinogenesis
#11
Xiao-Ming Liu, Can-Xia Xu, Lin-Fang Zhang, Li-Hua Huang, Ting-Zi Hu, Rong Li, Xiu-Juan Xia, Lin-Yong Xu, Ling Luo, Xiao-Xia Jiang, Ming Li
AIM: To clarify the mechanisms of connexin 32 (Cx32) downregulation by potential transcriptional factors (TFs) in Helicobacter pylori (H. pylori)-associated gastric carcinogenesis. METHODS: Approximately 25 specimens at each developmental stage of gastric carcinogenesis [non-atrophic gastritis, chronic atrophic gastritis, intestinal metaplasia, dysplasia and gastric carcinoma (GC)] with H. pylori infection [H. pylori (+)] and 25 normal gastric mucosa (NGM) without H...
August 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28830133/-associations-between-body-mass-index-and-chronic-atrophic-gastritis-and-intestinal-metaplasia
#12
Nari Kim, Chang Ho Youn, A Sol Kim, Hae Jin Ko, Hyo Min Kim, Hana Moon, Sujung Park
Background/Aims: Chronic atrophic gastritis (AG) and intestinal metaplasia (IM) of the stomach are premalignant lesions. The present study aimed to examine the associations between obesity and these lesions. Methods: A total of 2,997 patients, who underwent gastroscopy, participated in this study, excluding those who had been diagnosed with gastric cancer. Participants were divided into four groups based on their body mass index (BMI). The risk of AG and IM with increasing BMI was analyzed in men and women, separately...
August 25, 2017: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/28829504/reduced-mir-490-3p-expression-is-associated-with-poor-prognosis-of-helicobacter-pylori-induced-gastric-cancer
#13
M Qu, L Li, W-C Zheng
OBJECTIVE: Helicobacter pylori (HP) infection has been demonstrated to be a risk factor accounting for the initiation and development of gastric cancer (GC). The aim of the present study was to investigate the clinical significance of miR-490-3p in HP associated GC. PATIENTS AND METHODS: We measured the expression level of miR-490-3p in human GC tissues by quantitative Real-time PCR (qPCR). Then the association between miR-490-3p and clinical features of GC was further investigated...
August 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28791995/-morphological-and-immunohistochemical-features-of-severe-gastric-dysplasia-and-early-gastric-cancer
#14
L M Mikhaleva, A E Biryukov
AIM: to investigate the morphological and immunohistochemical features of severe gastric dysplasia (SGD) and early gastric cancer (EGC). MATERIAL AND METHODS: The fragments of gastric tumor tissue with adjacent mucosal portions from 50 patients aged from 34 to 79 years (mean age 63.8 years), which had been removed during organ-sparing endoscopic surgery, were histologically, histochemical, and immunohistochemically (IHC) examined. RESULTS: In EGC, there was a preponderance of intestinal-type cancer; the adjacent mucosal areas showed foci of SGD and colonic metaplasia in 100%...
2017: Arkhiv Patologii
https://www.readbyqxmd.com/read/28771198/prevention-of-gastric-cancer-eradication-of-helicobacter-pylori-and-beyond
#15
REVIEW
Tetsuya Tsukamoto, Mitsuru Nakagawa, Yuka Kiriyama, Takeshi Toyoda, Xueyuan Cao
Although its prevalence is declining, gastric cancer remains a significant public health issue. The bacterium Helicobacter pylori is known to colonize the human stomach and induce chronic atrophic gastritis, intestinal metaplasia, and gastric cancer. Results using a Mongolian gerbil model revealed that H. pylori infection increased the incidence of carcinogen-induced adenocarcinoma, whereas curative treatment of H. pylori significantly lowered cancer incidence. Furthermore, some epidemiological studies have shown that eradication of H...
August 3, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28768706/the-prevalence-of-cancer-associated-autoantibodies-in-patients-with-gastric-cancer-and-progressive-grades-of-premalignant-lesions
#16
Irēna Meistere, Simone Werner, Pawel Zayakin, Karīna Siliņa, Undīne Rulle, Angelina Pismennaja, Daiga Šantare, Ilze Kikuste, Sergejs Isajevs, Marcis Leja, Limas Kupčinskas, Juozas Kupčinskas, Laimas Jonaitis, Chun-Ying Wu, Hermann Brenner, Aija Linē, Zane Kalniņa
BACKGROUND: Serum autoantibodies against tumor-associated antigens (TAA) are detectable in early stage gastric cancer patients; however, the time point during cancerogenesis when they appear in circulation is still obscure. METHODS: In this study, we developed a recombinant antigen microarray and analyzed the prevalence of autoantibodies against 102 TAAs in 829 gastric cancer patients and 929 healthy controls from Caucasian and Asian populations, as well as 100 patients with chronic atrophic gastritis and 775 individuals staged according to different grades of intestinal metaplasia...
August 2, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28765474/mucosal-microbiome-dysbiosis-in-gastric-carcinogenesis
#17
Olabisi Oluwabukola Coker, Zhenwei Dai, Yongzhan Nie, Guijun Zhao, Lei Cao, Geicho Nakatsu, William Kk Wu, Sunny Hei Wong, Zigui Chen, Joseph J Y Sung, Jun Yu
OBJECTIVES: We aimed to characterise the microbial changes associated with histological stages of gastric tumourigenesis. DESIGN: We performed 16S rRNA gene analysis of gastric mucosal samples from 81 cases including superficial gastritis (SG), atrophic gastritis (AG), intestinal metaplasia (IM) and gastric cancer (GC) from Xi'an, China, to determine mucosal microbiome dysbiosis across stages of GC. We validated the results in mucosal samples of 126 cases from Inner Mongolia, China...
August 1, 2017: Gut
https://www.readbyqxmd.com/read/28753702/probe-based-endomicroscopy-for-in-vivo-detection-of-gastric-intestinal-metaplasia-and-neoplasia-a-multicenter-randomized-controlled-trial
#18
Xiu-Li Zuo, Zhen Li, Chang-Qing Li, You-You Zheng, Li-Dong Xu, Jie Chen, Rong Lin, Jun Song, Chao-Hui Yu, Min Yue, Qi Zhou, Zhi-Yan Liu, Yan-Qing Li
Background and study aims Owing to the indistinctive endoscopic appearance of gastric intestinal metaplasia (GIM), gastric intraepithelial neoplasia (GIN), and early gastric cancer (EGC), a significant number of such lesions may be missed during surveillance endoscopy. The aim of this clinical trial was to assess the value of combined computed virtual chromoendoscopy (flexible spectral imaging color enhancement [FICE]) and probe-based confocal laser endomicroscopy (pCLE) for in vivo detection of GIM, GIN, and EGC...
July 28, 2017: Endoscopy
https://www.readbyqxmd.com/read/28747552/tenascin-c-and-fibronectin-in-normal-esophageal-mucosa-barrett-s-esophagus-dysplasia-and-adenocarcinoma
#19
Joni Leppänen, Sara Bogdanoff, Petri P Lehenkari, Juha Saarnio, Joonas H Kauppila, Tuomo J Karttunen, Heikki Huhta, Olli Helminen
BACKGROUND: Tenascin-C and fibronectin are adhesive glycoproteins modulating the structure of the extracellular matrix and cellular functions. Their expression and function in esophageal adenocarcinoma is poorly known. The aim of this study was to evaluate the expression of tenascin-C and fibronectin in esophageal adenocarcinoma and its precursor stages. RESULTS: Stromal tenascin-C and fibronectin expression were found in all evaluated lesion types. Expression of both molecules increased from gastric metaplasia towards adenocarcinoma (p<0...
July 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28744336/oxidative-phosphorylation-system-in-gastric-carcinomas-and-gastritis
#20
René G Feichtinger, Daniel Neureiter, Tom Skaria, Silja Wessler, Timothy L Cover, Johannes A Mayr, Franz A Zimmermann, Gernot Posselt, Wolfgang Sperl, Barbara Kofler
Switching of cellular energy production from oxidative phosphorylation (OXPHOS) by mitochondria to aerobic glycolysis occurs in many types of tumors. However, the significance of this switching for the development of gastric carcinoma and what connection it may have to Helicobacter pylori infection of the gut, a primary cause of gastric cancer, are poorly understood. Therefore, we investigated the expression of OXPHOS complexes in two types of human gastric carcinomas ("intestinal" and "diffuse"), bacterial gastritis with and without metaplasia, and chemically induced gastritis by using immunohistochemistry...
2017: Oxidative Medicine and Cellular Longevity
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