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https://www.readbyqxmd.com/read/29775968/in-silico-structure-prediction-and-inhibition-mechanism-studies-of-athda14-as-revealed-by-homology-modeling-docking-molecular-dynamics-simulation
#1
Ming-Lang Zhao, Wang Wang, Hu Nie, Sha-Sha Cao, Lin-Fang Du
Histone deacetylases (HDACs) play a significant role in the epigenetic mechanism by catalyzing deacetylation of lysine on histone in both animals and plants. HDACs involved in growth, development and response to stresses in plants. Arabidopsis thaliana histone deacetylase 14 (AtHDA14) is found to localize in the mitochondria and chloroplasts, and it involved in photosynthesis and melatonin biosynthesis. However, its mechanism of action was still unknowns so far. Therefore, in this study, we constructed AtHDA14 protein model using homology modeling method, validated using PROCHECK and presented using Ramachandran plots...
May 6, 2018: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/29616987/the-crystal-structure-of-fe-2-pimic6-anthco-2-ch-3-cn-%C3%A2-fe-2-pimic6-anthco-2-ch-3-cn-0-9-ch-2-cl-2-0-1-%C3%A2-fe-2-pimic6-anthco-2-oh-2-%C3%A2-0-75ch-3-cn-a-crystallographer-s-nightmare-or-a-fascinating-case-of-disorder
#2
Sabine Becker
Refinement of large crystal structures as well as that of disordered structures can be challenging. If both features come together, structure refinement has the potential of becoming a crystallographer's nightmare. Here, the refinement of the large and highly disordered structure of [Fe2 (PIMIC6)(AnthCO2 )(CH3 CN)]·[Fe2 (PIMIC6)(AnthCO2 )(CH3 CN)0.9 (CH2 Cl2 )0.1 ]·[Fe2 (PIMIC6)(AnthCO2 )(OH2 )]·0.75CH3 CN [(1), PIMIC6 is a phenol-imine-based macrocycle, AnthCO2 is an anthracene acid anion] is described and discussed...
April 1, 2018: Acta Crystallographica Section B, Structural Science, Crystal Engineering and Materials
https://www.readbyqxmd.com/read/29273740/rna-sequencing-provides-insights-into-the-evolution-of-lettuce-and-the-regulation-of-flavonoid-biosynthesis
#3
Lei Zhang, Wenqing Su, Rong Tao, Weiyi Zhang, Jiongjiong Chen, Peiyao Wu, Chenghuan Yan, Yue Jia, Robert M Larkin, Dean Lavelle, Maria-Jose Truco, Sebastian Reyes Chin-Wo, Richard W Michelmore, Hanhui Kuang
Different horticultural types of lettuce exhibit tremendous morphological variation. However, the molecular basis for domestication and divergence among the different horticultural types of lettuce remains unknown. Here, we report the RNA sequencing of 240 lettuce accessions sampled from the major horticultural types and wild relatives, generating 1.1 million single-nucleotide polymorphisms (SNPs). Demographic modeling indicates that there was a single domestication event for lettuce. We identify a list of regions as putative selective sweeps that occurred during domestication and divergence, respectively...
December 22, 2017: Nature Communications
https://www.readbyqxmd.com/read/29065123/supplemental-arginine-vasopressin-during-the-resuscitation-of-severe-hemorrhagic-shock-preserves-renal-mitochondrial-function
#4
Carrie A Sims, Guan Yuxia, Khushboo Singh, Evan C Werlin, Patrick M Reilly, Joseph A Baur
Arginine vasopressin (AVP), a hormone secreted by the posterior pituitary, plays a vital role in maintaining vasomotor tone during acute blood loss. We hypothesized that decompensated hemorrhagic shock is associated with decreased AVP stores and supplementation during resuscitation would improve both blood pressure and renal function. Using a decompensated hemorrhagic shock model, male Long-Evans rats were bled to mean arterial blood pressure (MAP) of 40mmHg and maintained until the MAP could not be sustained without fluid...
2017: PloS One
https://www.readbyqxmd.com/read/29045025/do-pre-operative-oral-antibiotics-increase-clostridium-difficile-infection-rates-an-analysis-of-13-959-colectomy-patients
#5
Muralidharan Parthasarathy, David Bowers, Thomas Groot-Wassink
AIM: The aim of this study was to determine whether or not preoperative oral antibiotic preparation (POAP) increases the rate of Clostridium difficile colitis (CDC) in patients undergoing colectomy. METHOD: In 2015, data for colectomies had been collected prospectively and recorded in the targeted colectomy option of the American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP). This was available for retrospective analysis. Data available for analysis included elective and emergency status, POAP, surgical approach, primary anastomosis and CDC status...
October 16, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/29024729/integrating-genome-wide-association-study-and-expression-quantitative-trait-locus-study-identifies-multiple-genes-and-gene-sets-associated-with-schizophrenia
#6
Yan Zhao, Awen He, Feng Zhu, Miao Ding, Jingcan Hao, Qianrui Fan, Ping Li, Li Liu, Yanan Du, Xiao Liang, Xiong Guo, Feng Zhang, Xiancang Ma
Schizophrenia is a serious mental disease with high heritability. To better understand the genetic basis of schizophrenia, we conducted a large scale integrative analysis of genome-wide association study (GWAS) and expression quantitative trait loci (eQTLs) data. GWAS summary data was derived from a published GWAS of schizophrenia, containing 9394 schizophrenia patients and 12,462 healthy controls. The eQTLs dataset was obtained from an eQTLs meta-analysis of 5311 subjects, containing 923,021 cis-eQTLs for 14,329 genes and 4732 trans-eQTLs for 2612 genes...
October 9, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28552732/integrating-genome-wide-association-study-and-expression-quantitative-trait-loci-data-identifies-multiple-genes-and-gene-set-associated-with-neuroticism
#7
Qianrui Fan, Wenyu Wang, Jingcan Hao, Awen He, Yan Wen, Xiong Guo, Cuiyan Wu, Yujie Ning, Xi Wang, Sen Wang, Feng Zhang
Neuroticism is a fundamental personality trait with significant genetic determinant. To identify novel susceptibility genes for neuroticism, we conducted an integrative analysis of genomic and transcriptomic data of genome wide association study (GWAS) and expression quantitative trait locus (eQTL) study. GWAS summary data was driven from published studies of neuroticism, totally involving 170,906 subjects. eQTL dataset containing 927,753 eQTLs were obtained from an eQTL meta-analysis of 5311 samples. Integrative analysis of GWAS and eQTL data was conducted by summary data-based Mendelian randomization (SMR) analysis software...
August 1, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28374312/defining-gas-phase-fragmentation-propensities-of-intact-proteins-during-native-top-down-mass-spectrometry
#8
Nicole A Haverland, Owen S Skinner, Ryan T Fellers, Areeba A Tariq, Bryan P Early, Richard D LeDuc, Luca Fornelli, Philip D Compton, Neil L Kelleher
Fragmentation of intact proteins in the gas phase is influenced by amino acid composition, the mass and charge of precursor ions, higher order structure, and the dissociation technique used. The likelihood of fragmentation occurring between a pair of residues is referred to as the fragmentation propensity and is calculated by dividing the total number of assigned fragmentation events by the total number of possible fragmentation events for each residue pair. Here, we describe general fragmentation propensities when performing top-down mass spectrometry (TDMS) using denaturing or native electrospray ionization...
June 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/28111972/the-association-of-antidepressant-and-statin-use-with-death-and-incident-cardiovascular-disease-varies-by-depression-severity
#9
Heidi T May, Tami L Bair, Brenda Reiss-Brennan, Stacey Knight, Jeffrey L Anderson, Benjamin D Horne, Kimberly D Brunisholz, Joseph B Muhlestein
Depression has been reported to be associated with a greater risk of death and cardiovascular disease (CVD); however, the impact of antidepressants (ADM) on CVD risk remains controversial. Statin use is known to decrease CVD risk. Whether the use of these medications together affects CVD risk has not been studied. Patients (N = 26,828) completing the patient health questionnaire (PHQ-9), ≥40 years of age, without prior CVD, and no prior ADM use were studied. Depressive severity was categorized as none-mild (PHQ-9 score ≤14, n = 21,517) and moderate-severe (PHQ-9 score ≥15, n = 5311)...
September 2017: Psychology, Health & Medicine
https://www.readbyqxmd.com/read/28017895/mobbing-among-care-workers-in-nursing-homes-a-cross-sectional-secondary-analysis-of-the-swiss-nursing-homes-human-resources-project
#10
MULTICENTER STUDY
Myriam Tong, René Schwendimann, Franziska Zúñiga
BACKGROUND: As a category of bullying, mobbing is a form of violence in the workplace that damages the employing organization as well as the targeted employee. In Europe, the overall prevalence of mobbing in healthcare is estimated at 4%. However, few studies have explored mobbing among long-term care workers. OBJECTIVES: This study aims to examine the frequency of mobbing in Swiss nursing homes and its relationships with care workers' (i.e. registered nurse, licensed practical nurse, assistant nurse, nurse aide) health status, job satisfaction, and intention to leave, and to explore the work environment as a contributing factor to mobbing...
January 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/27714588/cancer-screening-among-patients-who-self-identify-as-muslim-combining-self-reported-data-with-medical-records-in-a-family-practice-setting
#11
A K Lofters, M Slater, M Vahabi
Cancer screening is a core component of family medicine but screening inequalities are well documented in Canada for foreign-born persons. Although people of Muslim faith and culture are the fastest growing immigrant population in Canada, there is little information in the literature about their cancer screening practices. Determining screening gaps could inform practice-based quality improvement initiatives. We conducted a retrospective chart review combining patient-level medical record data with self-reported religious affiliation to examine the relationship between religion and cancer screening in a large multi-site urban family practice...
October 6, 2016: Journal of Immigrant and Minority Health
https://www.readbyqxmd.com/read/27689761/is-there-an-association-of-epidural-corticosteroid-injection-with-postoperative-surgical-site-infection-after-surgery-for-lumbar-degenerative-spine-disease
#12
Stefan Hartveldt, Stein J Janssen, Kirkham B Wood, Thomas D Cha, Joseph H Schwab, Christopher M Bono, Louis G Jenis
STUDY DESIGN: Retrospective study. OBJECTIVE: To assess the relation between exposure to epidural steroid injection (ESI) before surgery and occurrence of surgical site infection (SSI) for degenerative lumbar spine conditions. SUMMARY OF BACKGROUND DATA: The effect of local ESI on the occurrence of SSI is controversial. METHODS: Patients who underwent surgery for degenerative lumbar spine conditions at two centers between 2005 and 2015 were identified...
October 1, 2016: Spine
https://www.readbyqxmd.com/read/27521953/effects-of-sulfate-reducing-bacteria-on-methylmercury-at-the-sediment-water-interface
#13
Lingxia Zeng, Guangjun Luo, Tianrong He, Yanna Guo, Xiaoli Qian
Sediment cores (containing sediment and overlying water) from Baihua Reservoir (SW China) were cultured under different redox conditions with different microbial activities, to understand the effects of sulfate-reducing bacteria (SRB) on mercury (Hg) methylation at sediment-water interfaces. Concentrations of dissolved methyl mercury (DMeHg) in the overlying water of the control cores with bioactivity maintained (BAC) and cores with only sulfate-reducing bacteria inhibited (SRBI) and bacteria fully inhibited (BACI) were measured at the anaerobic stage followed by the aerobic stage...
August 2016: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/26769743/congenital-heart-defects-and-indices-of-fetal-cerebral-growth-in-a-nationwide-cohort-of-924-422-liveborn-infants
#14
Niels B Matthiesen, Tine B Henriksen, J William Gaynor, Peter Agergaard, Cathrine C Bach, Vibeke E Hjortdal, John R Østergaard
BACKGROUND: Neurodevelopmental disorders are the most common and distressful comorbidities associated with congenital heart defects (CHD). Head circumference at birth (HC), a proxy for prenatal cerebral growth, is an established risk factor for neurodevelopmental disorders. METHODS AND RESULTS: In a nationwide cohort, we included all 924 422 liveborn Danish singletons, 1997 to 2011. CHD was present in 5519. The association between CHD and growth indices was analyzed by multivariable linear regression, adjusted for potential confounders...
February 9, 2016: Circulation
https://www.readbyqxmd.com/read/26593573/antioxidant-phenolic-extracts-obtained-from-secondary-tunisian-date-varieties-phoenix-dactylifera-l-by-hydrothermal-treatments
#15
Abdessalem Mrabet, Ana Jiménez-Araujo, Juan Fernández-Bolaños, Fátima Rubio-Senent, Antonio Lama-Muñoz, Marianne Sindic, Guillermo Rodríguez-Gutiérrez
Three common non-commercial Tunisian date varieties were treated by two thermal systems, obtaining a liquid fraction which was characterized and its antioxidant capacity determined. The concentration of total phenols in the three varieties (Smeti, Garen Gazel, and Eguwa) was increased by steam explosion treatment up to 5311, 4680, and 3832 mg/kg of fresh dates, and their antioxidant activity up to 62.5, 46.5 and 43.1 mmol Trolox/kg of fresh date, respectively. Both thermal treatments increased the content of phenolic acids...
April 1, 2016: Food Chemistry
https://www.readbyqxmd.com/read/26467582/childhood-tuberculosis-and-human-immunodeficiency-virus-status-in-brazil-a-hierarchical-analysis
#16
E dos Santos Dias, T N do Prado, A L da Silva Guimarães, M C Ramos, C M M Sales, E de Fátima Almeida Lima, C C Sant'Anna, M Sanchez, E L Maciel
SETTING: Human immunodeficiency virus (HIV) infection may impact tuberculosis (TB) diagnosis, clinical presentation and treatment outcomes in children as the signs and symptoms of both diseases overlap. OBJECTIVE: To compare the sociodemographic and clinical profiles of childhood TB according to HIV status in Brazil. METHODS: This was a cross-sectional study of data on subjects aged <15 years retrieved from the Brazilian National Electronic Disease Registry (Sistema de Informação de Agravos de Notificação) database on TB to compare TB-HIV coinfected patients and patients with TB only registered between 2007 and 2011...
November 2015: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/26457723/additional-behavioural-support-as-an-adjunct-to-pharmacotherapy-for-smoking-cessation
#17
REVIEW
Lindsay F Stead, Priya Koilpillai, Tim Lancaster
BACKGROUND: Effective pharmacotherapies are available to help people who are trying to stop smoking, but quitting can still be difficult and providing higher levels of behavioural support may increase success rates further. OBJECTIVES: To evaluate the effect of increasing the intensity of behavioural support for people using smoking cessation medications, and to assess whether there are different effects depending on the type of pharmacotherapy, or the amount of support in each condition...
2015: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/26309023/effectiveness-of-provider-and-community-interventions-to-improve-treatment-of-uncomplicated-malaria-in-nigeria-a-cluster-randomized-controlled-trial
#18
RANDOMIZED CONTROLLED TRIAL
Obinna Onwujekwe, Lindsay Mangham-Jefferies, Bonnie Cundill, Neal Alexander, Julia Langham, Ogochukwu Ibe, Benjamin Uzochukwu, Virginia Wiseman
UNLABELLED: The World Health Organization recommends that malaria be confirmed by parasitological diagnosis before treatment using Artemisinin-based Combination Therapy (ACT). Despite this, many health workers in malaria endemic countries continue to diagnose malaria based on symptoms alone. This study evaluates interventions to help bridge this gap between guidelines and provider practice. A stratified cluster-randomized trial in 42 communities in Enugu state compared 3 scenarios: Rapid Diagnostic Tests (RDTs) with basic instruction (control); RDTs with provider training (provider arm); and RDTs with provider training plus a school-based community intervention (provider-school arm)...
2015: PloS One
https://www.readbyqxmd.com/read/26216215/alcohol-use-in-the-military-associations-with-health-and-wellbeing
#19
Michael Waller, Annabel C L McGuire, Annette J Dobson
BACKGROUND: This study assessed the extent to which alcohol consumption in a military group differed from the general population, and how alcohol affected the military group's health and social functioning. METHODS: A cross sectional survey of military personnel (n = 5311) collected self-reported data on alcohol use (AUDIT scale) and general health, role limitations because of physical health problems (role physical), and social functioning scores (SF36 subscales)...
2015: Substance Abuse Treatment, Prevention, and Policy
https://www.readbyqxmd.com/read/26068955/topical-nsaids-for-acute-musculoskeletal-pain-in-adults
#20
REVIEW
Sheena Derry, R Andrew Moore, Helen Gaskell, Mairead McIntyre, Philip J Wiffen
BACKGROUND: Use of topical NSAIDs to treat acute musculoskeletal conditions has become widely accepted because they can provide pain relief without associated systemic adverse events. This review is an update of 'Topical NSAIDs for acute pain in adults' originally published in Issue 6, 2010. OBJECTIVES: To determine the efficacy and safety of topically applied NSAIDs in acute musculoskeletal pain in adults. SEARCH METHODS: We searched the Cochrane Register of Studies Online, MEDLINE, and EMBASE to February 2015...
June 11, 2015: Cochrane Database of Systematic Reviews
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