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Qianrui Fan, Wenyu Wang, Jingcan Hao, Awen He, Yan Wen, Xiong Guo, Cuiyan Wu, Yujie Ning, Xi Wang, Sen Wang, Feng Zhang
Neuroticism is a fundamental personality trait with significant genetic determinant. To identify novel susceptibility genes for neuroticism, we conducted an integrative analysis of genomic and transcriptomic data of genome wide association study (GWAS) and expression quantitative trait locus (eQTL) study. GWAS summary data was driven from published studies of neuroticism, totally involving 170,906 subjects. eQTL dataset containing 927,753 eQTLs were obtained from an eQTL meta-analysis of 5311 samples. Integrative analysis of GWAS and eQTL data was conducted by summary data-based Mendelian randomization (SMR) analysis software...
May 25, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
Nicole A Haverland, Owen S Skinner, Ryan T Fellers, Areeba A Tariq, Bryan P Early, Richard D LeDuc, Luca Fornelli, Philip D Compton, Neil L Kelleher
Fragmentation of intact proteins in the gas phase is influenced by amino acid composition, the mass and charge of precursor ions, higher order structure, and the dissociation technique used. The likelihood of fragmentation occurring between a pair of residues is referred to as the fragmentation propensity and is calculated by dividing the total number of assigned fragmentation events by the total number of possible fragmentation events for each residue pair. Here, we describe general fragmentation propensities when performing top-down mass spectrometry (TDMS) using denaturing or native electrospray ionization...
June 2017: Journal of the American Society for Mass Spectrometry
Heidi T May, Tami L Bair, Brenda Reiss-Brennan, Stacey Knight, Jeffrey L Anderson, Benjamin D Horne, Kimberly D Brunisholz, Joseph B Muhlestein
Depression has been reported to be associated with a greater risk of death and cardiovascular disease (CVD); however, the impact of antidepressants (ADM) on CVD risk remains controversial. Statin use is known to decrease CVD risk. Whether the use of these medications together affects CVD risk has not been studied. Patients (N = 26,828) completing the patient health questionnaire (PHQ-9), ≥40 years of age, without prior CVD, and no prior ADM use were studied. Depressive severity was categorized as none-mild (PHQ-9 score ≤14, n = 21,517) and moderate-severe (PHQ-9 score ≥15, n = 5311)...
January 22, 2017: Psychology, Health & Medicine
Myriam Tong, René Schwendimann, Franziska Zúñiga
BACKGROUND: As a category of bullying, mobbing is a form of violence in the workplace that damages the employing organization as well as the targeted employee. In Europe, the overall prevalence of mobbing in healthcare is estimated at 4%. However, few studies have explored mobbing among long-term care workers. OBJECTIVES: This study aims to examine the frequency of mobbing in Swiss nursing homes and its relationships with care workers' (i.e. registered nurse, licensed practical nurse, assistant nurse, nurse aide) health status, job satisfaction, and intention to leave, and to explore the work environment as a contributing factor to mobbing...
December 15, 2016: International Journal of Nursing Studies
A K Lofters, M Slater, M Vahabi
Cancer screening is a core component of family medicine but screening inequalities are well documented in Canada for foreign-born persons. Although people of Muslim faith and culture are the fastest growing immigrant population in Canada, there is little information in the literature about their cancer screening practices. Determining screening gaps could inform practice-based quality improvement initiatives. We conducted a retrospective chart review combining patient-level medical record data with self-reported religious affiliation to examine the relationship between religion and cancer screening in a large multi-site urban family practice...
October 6, 2016: Journal of Immigrant and Minority Health
Stefan Hartveldt, Stein J Janssen, Kirkham B Wood, Thomas D Cha, Joseph H Schwab, Christopher M Bono, Louis G Jenis
STUDY DESIGN: Retrospective study. OBJECTIVE: To assess the relation between exposure to epidural steroid injection (ESI) before surgery and occurrence of surgical site infection (SSI) for degenerative lumbar spine conditions. SUMMARY OF BACKGROUND DATA: The effect of local ESI on the occurrence of SSI is controversial. METHODS: Patients who underwent surgery for degenerative lumbar spine conditions at two centers between 2005 and 2015 were identified...
October 1, 2016: Spine
Lingxia Zeng, Guangjun Luo, Tianrong He, Yanna Guo, Xiaoli Qian
Sediment cores (containing sediment and overlying water) from Baihua Reservoir (SW China) were cultured under different redox conditions with different microbial activities, to understand the effects of sulfate-reducing bacteria (SRB) on mercury (Hg) methylation at sediment-water interfaces. Concentrations of dissolved methyl mercury (DMeHg) in the overlying water of the control cores with bioactivity maintained (BAC) and cores with only sulfate-reducing bacteria inhibited (SRBI) and bacteria fully inhibited (BACI) were measured at the anaerobic stage followed by the aerobic stage...
August 2016: Journal of Environmental Sciences (China)
Niels B Matthiesen, Tine B Henriksen, J William Gaynor, Peter Agergaard, Cathrine C Bach, Vibeke E Hjortdal, John R Østergaard
BACKGROUND: Neurodevelopmental disorders are the most common and distressful comorbidities associated with congenital heart defects (CHD). Head circumference at birth (HC), a proxy for prenatal cerebral growth, is an established risk factor for neurodevelopmental disorders. METHODS AND RESULTS: In a nationwide cohort, we included all 924 422 liveborn Danish singletons, 1997 to 2011. CHD was present in 5519. The association between CHD and growth indices was analyzed by multivariable linear regression, adjusted for potential confounders...
February 9, 2016: Circulation
Abdessalem Mrabet, Ana Jiménez-Araujo, Juan Fernández-Bolaños, Fátima Rubio-Senent, Antonio Lama-Muñoz, Marianne Sindic, Guillermo Rodríguez-Gutiérrez
Three common non-commercial Tunisian date varieties were treated by two thermal systems, obtaining a liquid fraction which was characterized and its antioxidant capacity determined. The concentration of total phenols in the three varieties (Smeti, Garen Gazel, and Eguwa) was increased by steam explosion treatment up to 5311, 4680, and 3832 mg/kg of fresh dates, and their antioxidant activity up to 62.5, 46.5 and 43.1 mmol Trolox/kg of fresh date, respectively. Both thermal treatments increased the content of phenolic acids...
April 1, 2016: Food Chemistry
E dos Santos Dias, T N do Prado, A L da Silva Guimarães, M C Ramos, C M M Sales, E de Fátima Almeida Lima, C C Sant'Anna, M Sanchez, E L Maciel
SETTING: Human immunodeficiency virus (HIV) infection may impact tuberculosis (TB) diagnosis, clinical presentation and treatment outcomes in children as the signs and symptoms of both diseases overlap. OBJECTIVE: To compare the sociodemographic and clinical profiles of childhood TB according to HIV status in Brazil. METHODS: This was a cross-sectional study of data on subjects aged <15 years retrieved from the Brazilian National Electronic Disease Registry (Sistema de Informação de Agravos de Notificação) database on TB to compare TB-HIV coinfected patients and patients with TB only registered between 2007 and 2011...
November 2015: International Journal of Tuberculosis and Lung Disease
Lindsay F Stead, Priya Koilpillai, Tim Lancaster
BACKGROUND: Effective pharmacotherapies are available to help people who are trying to stop smoking, but quitting can still be difficult and providing higher levels of behavioural support may increase success rates further. OBJECTIVES: To evaluate the effect of increasing the intensity of behavioural support for people using smoking cessation medications, and to assess whether there are different effects depending on the type of pharmacotherapy, or the amount of support in each condition...
2015: Cochrane Database of Systematic Reviews
Obinna Onwujekwe, Lindsay Mangham-Jefferies, Bonnie Cundill, Neal Alexander, Julia Langham, Ogochukwu Ibe, Benjamin Uzochukwu, Virginia Wiseman
UNLABELLED: The World Health Organization recommends that malaria be confirmed by parasitological diagnosis before treatment using Artemisinin-based Combination Therapy (ACT). Despite this, many health workers in malaria endemic countries continue to diagnose malaria based on symptoms alone. This study evaluates interventions to help bridge this gap between guidelines and provider practice. A stratified cluster-randomized trial in 42 communities in Enugu state compared 3 scenarios: Rapid Diagnostic Tests (RDTs) with basic instruction (control); RDTs with provider training (provider arm); and RDTs with provider training plus a school-based community intervention (provider-school arm)...
2015: PloS One
Michael Waller, Annabel C L McGuire, Annette J Dobson
BACKGROUND: This study assessed the extent to which alcohol consumption in a military group differed from the general population, and how alcohol affected the military group's health and social functioning. METHODS: A cross sectional survey of military personnel (n = 5311) collected self-reported data on alcohol use (AUDIT scale) and general health, role limitations because of physical health problems (role physical), and social functioning scores (SF36 subscales)...
2015: Substance Abuse Treatment, Prevention, and Policy
Sheena Derry, R Andrew Moore, Helen Gaskell, Mairead McIntyre, Philip J Wiffen
BACKGROUND: Use of topical NSAIDs to treat acute musculoskeletal conditions has become widely accepted because they can provide pain relief without associated systemic adverse events. This review is an update of 'Topical NSAIDs for acute pain in adults' originally published in Issue 6, 2010. OBJECTIVES: To determine the efficacy and safety of topically applied NSAIDs in acute musculoskeletal pain in adults. SEARCH METHODS: We searched the Cochrane Register of Studies Online, MEDLINE, and EMBASE to February 2015...
June 11, 2015: Cochrane Database of Systematic Reviews
Stephanie R Partridge, Kate Balestracci, Annette Ty Wong, Lana Hebden, Kevin McGeechan, Elizabeth Denney-Wilson, Mark F Harris, Philayrath Phongsavan, Adrian Bauman, Margaret Allman-Farinelli
BACKGROUND: Younger adults are difficult to engage in preventive health, yet in Australia they are gaining more weight and increasing in waist circumference faster than middle-to-older adults. A further challenge to engaging 18- to 35-year-olds in interventions is the limited reporting of outcomes of recruitment strategies. OBJECTIVE: This paper describes the outcomes of strategies used to recruit young adults to a randomized controlled trial (RCT), healthy lifestyle mHealth program, TXT2BFiT, for prevention of weight gain...
2015: JMIR Research Protocols
Anshuman Mishra, Sheikh Nizamuddin, Geethika Arekatla, Satya Prakash, Hemlata Dewangan, Abishai Dominic, Abhishek Mishra, Digumarthi V S Sudhakar, Narasimha R Parine, Nitin C Tupperwar, Kumarasamy Thangaraj
BACKGROUND: Visceral leishmaniasis (VL) is a multifactorial disease, where the host genetics play a significant role in determining the disease outcome. The immunological role of anti-inflammatory cytokine, Interleukin 10 (IL10), has been well-documented in parasite infections and considered as a key regulatory cytokine for VL. Although VL patients in India display high level of IL10 in blood serum, no genetic study has been conducted to assess the VL susceptibility / resistance. Therefore, the aim of this study is to investigate the role of IL10 variations in Indian VL; and to estimate the distribution of disease associated allele in diverse Indian populations...
2015: PloS One
Wesley T O'Neal, Elsayed Z Soliman, Waqas Qureshi, Alvaro Alonso, Susan R Heckbert, David Herrington
The association between sustained pre-hypertension and atrial fibrillation (AF) has not been thoroughly examined. This study included 5311 participants (mean age 62 ± 10 years; 47% male; 42.9% non-whites) from the Multi-Ethnic Study of Atherosclerosis. Sustained exposure was based on 2 or more visits within the same blood pressure category (optimal, <120/80 mm Hg; pre-hypertension, 120-139/80-89 mm Hg; hypertension, ≥140/90 mm Hg or antihypertensive medication use) during visits 1, 2, and 3. Cox regression was used to compute hazard ratios (HR) and 95% confidence intervals (CI) for the association between blood pressure category and AF...
March 2015: Journal of the American Society of Hypertension: JASH
Orianne Dumas, Raphaëlle Varraso, Jan Paul Zock, Paul K Henneberger, Frank E Speizer, Aleta S Wiley, Nicole Le Moual, Carlos A Camargo
OBJECTIVES: Nurses are at increased risk of occupational asthma, an observation that may be related to disinfectants exposure. Whether asthma history influences job type or job changes among nurses is unknown. We investigated this issue in a large cohort of nurses. METHODS: The Nurses' Health Study II is a prospective study of US female nurses enrolled in 1989 (ages 24-44 years). Job status and asthma were assessed in biennial (1989-2011) and asthma-specific questionnaires (1998, 2003)...
July 2015: Occupational and Environmental Medicine
Jomon P Jacob, M Sithambaresan, Christy Kunjachan, M R Prathapachandra Kurup
The title compound, C40H22Cl2O4, was formed by a Michael-Aldol domino reaction sequence, which coupled acenaphthene-quinone with 4-chloro-aceto-phenone in the presence of KOH in methanol. The dihedral angles between the central cyclo-penta-[a]ace-naphthyl-ene fused-ring system (r.m.s. deviation = 0.066 Å) and the 4-chloro-benzoyl rings are 62.25 (10) and 70.19 (10)°. The dihedral angle between the central ring system and the naphthoic acid grouping is 62.46 (7)°. This twisting of the pendant rings facilitates the formation of an intra-molecular aromatic π-π stacking inter-action between the 4-chloro-benzoyl and naphthoic acid rings, with centroid-centroid distances of 3...
January 1, 2015: Acta Crystallographica. Section E, Crystallographic Communications
Paula Arrabal-Durán, M Esther Durán-García, Almudena Ribed-Sánchez, Patricia Hidalgo-Collazos, María Sanjurjo-Sáez
BACKGROUND: Chronic Renal Failure (CRF) is a disease that requires determined medications dosages to be adjusted. OBJECTIVES: To assess the characteristics of pharmaceutical interventions concerning the dose adjustment of these drugs in patients with CRF who are admitted into hospital. METHODS: A 10-month prospective and longitudinal study that calculated the glomerular filtration rate of patients who are brought into the emergency department and had values below 50ml/min/1...
November 17, 2014: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
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