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Pediatric transfusion

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https://www.readbyqxmd.com/read/29904575/recent-advances-in-transfusions-in-neonates-infants
#1
REVIEW
Ruchika Goel, Cassandra D Josephson
Transfusions of red blood cells (RBCs), platelets, and plasma are critical therapies for infants and neonates (particularly preterm neonates) in the neonatal intensive care unit, who are the most frequently transfused subpopulation across all ages. Although traditionally a significant gap has existed between the blood utilization and the evidence base essential to adequately guide transfusion practices in infants and neonates, pediatric transfusion medicine is evolving from infancy and gradually coming of age...
2018: F1000Research
https://www.readbyqxmd.com/read/29902780/contribution-of-fetal-brain-mri-in-management-of-severe-fetal-anemia
#2
L Ghesquière, V Houfflin-Debarge, P Verpillat, T Fourquet, S Joriot, C Coulon, P Vaast, C Garabedian
INTRODUCTION: Intrauterine transfusion (IUT) has changed fetal anemia prognosis. However, long-term neurodevelopmental outcome is altered in 5% of children. Our objective was to study the contribution of fetal MRI to diagnosis brain lesions in case of fetal anemia. MATERIAL AND METHODS: Retrospective monocentric descriptive study from 2005 to 2016, including all patients followed for fetal anemia requiring IUT. The indications for MRI were: hydrops fetalis and / or hemoglobin <5 g / dL and / or more than 3 IUTs and / or acute severe anemia and / or ultrasound abnormality...
June 6, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29902465/national-benchmarks-of-proportions-of-patients-receiving-transfusions-during-pediatric-heart-surgery
#3
Vyas M Kartha, Mohamed Rehman, Jeffrey P Jacobs, Marshall L Jacobs, David Vener, Kevin D Hill, James M Meza, Sean M O'Brien, Liqi Feng, Karen Chiswell, Neil A Goldenberg, Sara K Pasquali, Pirooz Eghtesady, Vinay Badhwar
BACKGROUND: To determine national benchmarks and assess variability across centers, the STS Congenital Heart Surgery Database (CHSD) was analyzed to document proportions of patients receiving intraoperative blood transfusion during open heart surgery. METHODS: Index CPB operations reported in the STS CHSD (2014-2015) were potentially eligible for inclusion. Data from centers with > 15% missing data for packed red blood cell (PRBC) transfusion were excluded, as were individual records missing information about PRBC transfusion...
June 11, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29899767/spontaneous-concurrent-intraspinal-and-intracranial-subdural-hematoma-management-and-review-of-literature
#4
REVIEW
Guru Dutta Satyarthee, Faiz Ahmad
Concurrent occurrence of subdural hematoma (SDH) in the cranial as well as spinal compartment of craniospinal axis is extremely uncommon. In a detailed PubMed/Medline search, we could find only four cases of spontaneous concurrent craniospinal SDH, and adding our one case to the preexisting literature and thus reviewing total five cases. Spontaneous concurrent intraspinal and intracranial subdural hematoma affected exclusively male in their fourth to fifth decades of life with a mean age of 37.4 years (range 14-59 years)...
January 2018: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/29891188/development-of-a-postoperative-care-pathway-for-children-with-renal-tumors
#5
A F Saltzman, J C Warncke, A N Colvin, A Carrasco, J P Roach, J L Bruny, N G Cost
PURPOSE: To identify the factors associated with a shorter postoperative stay, as an initial step to develop a care pathway for children undergoing extirpative kidney surgery. STUDY DESIGN: This study retrospectively reviewed patients managed with upfront open radical nephrectomy for renal tumors between 2005 and 2016 at a pediatric tertiary care facility. Univariate and multivariate logistic regression were performed to identify factors associated with early discharge (by postoperative day 4)...
May 31, 2018: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29887185/pediatric-transfusion-global-perspectives-on-some-clinical-and-methodological-aspects-of-cellular-therapy-apheresis-emergencies-and-blood-transfusion-in-pediatric-patients
#6
EDITORIAL
Jerard Segatchian, Irena Sniecinski
No abstract text is available yet for this article.
May 9, 2018: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29886914/development-of-consensus-based-best-practice-guidelines-for-perioperative-management-of-blood-loss-in-patients-undergoing-posterior-spinal-fusion-for-adolescent-idiopathic-scoliosis
#7
Nicholas D Fletcher, Michelle C Marks, Jahangir K Asghar, Steven W Hwang, Paul D Sponseller, Peter O Newton
STUDY DESIGN: Delphi process with multiple iterative rounds using a nominal group technique. OBJECTIVE: The aim of this study was to use expert opinion to achieve consensus on various methods for minimizing blood loss in patients undergoing posterior spinal fusion (PSF) for adolescent idiopathic scoliosis (AIS). BACKGROUND DATA: Perioperative blood loss management represents a critical component of safely performing PSF in children with AIS...
July 2018: Spine Deformity
https://www.readbyqxmd.com/read/29877982/evaluating-the-national-surgical-quality-improvement-program-pediatric-surgical-risk-calculator-for-pediatric-craniosynostosis-surgery
#8
Nisha Gadgil, I-Wen Pan, Solomon Babalola, Sandi Lam
BACKGROUND: The American College of Surgeons' National Surgical Quality Improvement Program-Pediatric (NSQIP-P) risk calculator was developed based on national data. There have been no studies assessing the risk calculator's performance in pediatric neurosurgery. The authors aimed to evaluate the predictions from the risk calculator compared to our single institution experience in craniosynostosis surgery. METHODS: Outcomes from craniosynostosis surgeries performed between 2012 and 2016 at our academic pediatric hospital were evaluated using the NSQIP-P risk calculator...
June 5, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29858913/comparison-of-miniaturized-percutaneous-nephrolithotomy-and-standard-percutaneous-nephrolithotomy-for-the-treatment-of-large-kidney-stones-a-randomized-prospective-study
#9
Ali Güler, Akif Erbin, Burak Ucpinar, Metin Savun, Omer Sarilar, Mehmet Fatih Akbulut
We aimed to compare the outcomes of mini-percutaneous nephrolithotomy (mPNL) and standard PNL techniques in the treatment of renal stones ≥ 2 cm. The study was designed as a randomized prospective study between January 2016 and April 2017. The patients with a kidney stone ≥ 2 cm were included in the study. Patients who had uncorrectable bleeding diathesis, abnormal renal anatomy, skeletal tract abnormalities, pregnant patients and pediatric patients (< 18 years old) were excluded from the study...
June 1, 2018: Urolithiasis
https://www.readbyqxmd.com/read/29847540/patients-at-high-risk-of-intervention-for-pediatric-traumatic-liver-injury
#10
Katie A Donnelly, Kristen Breslin, Karen J OʼConnell
OBJECTIVES: Nonoperative management of hemodynamically stable liver lacerations in pediatric trauma patients is a safe and effective management strategy for pediatric patients; approximately 90% will be successfully managed nonoperatively. No study has specifically identified risk criteria for the need for intervention versus observation alone. Our objective for this study was to determine risk factors from the physical examination, computed tomography scan, and laboratory results associated with intervention for liver laceration...
May 25, 2018: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29807476/posttonsillectomy-hemorrhage-in-a-pediatric-jehovah-s-witness-and-the-decision-to-transfuse
#11
Andrew J Redmann, Melissa Schopper, Judith Ragsdale, Michael J Rutter, Catherine K Hart, Charles M Myer
No abstract text is available yet for this article.
May 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29804934/pediatric-red-cell-and-platelet-transfusions
#12
REVIEW
Çiğdem Akalın Akkök, Jerard Seghatchian
The aim of pediatric transfusions should be based on the concept of avoiding unnecessary transfusions without jeopardizing the patient safety and providing correct blood components when there are well founded indications to transfuse. Despite considerable efforts from transfusion services to increase transfusion safety, transfusions are still associated with preventable and unpreventable adverse effects that may, in the worst case, have severe and fatal consequences. Transfusions to pediatric patients constitute a small proportion of all transfusions but have higher incidence of adverse events compared to adults...
May 16, 2018: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29802007/estimation-of-blood-loss-during-adult-burn-surgery
#13
B Farny, M Fontaine, J Latarjet, J C Poupelin, D Voulliaume, F Ravat
INTRODUCTION: Large burns excision and graft can produce major blood loss. The main objective of this study is to evaluate the blood loss in relation with the excision size in square centimeters (cm2 ) in adults. PATIENTS AND METHODS: We conducted a monocentric, observational, prospective and open study in a burn intensive care unit. Patients aged-over 18 with burn wounds excision and autografting covering at least 5% of total body surface area (TBS) were enrolled...
May 22, 2018: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29797644/sickle-cell-clinical-research-and-intervention-program-sccrip-a-lifespan-cohort-study-for-sickle-cell-disease-progression-from-the-pediatric-stage-into-adulthood
#14
Jane S Hankins, Jeremie H Estepp, Jason R Hodges, Martha A Villavicencio, Leslie L Robison, Mitchell J Weiss, Guolian Kang, Jane E Schreiber, Jerlym S Porter, Sue C Kaste, Kay L Saving, Paulette C Bryant, Jeffrey E Deyo, Kerri A Nottage, Allison A King, Amanda M Brandow, Jeffrey D Lebensburger, Oyebimpe Adesina, Stella T Chou, Babette S Zemel, Matthew P Smeltzer, Winfred C Wang, James G Gurney
BACKGROUND: Previous natural history studies have advanced the understanding of sickle cell disease (SCD), but generally have not included sufficient lifespan data or investigation of the role of genetics in clinical outcomes, and have often occurred before the widespread use of disease-modifying therapies, such as hydroxyurea and chronic erythrocyte transfusions. To further advance knowledge of SCD, St. Jude Children's Research Hospital established the Sickle Cell Clinical Research and Intervention Program (SCCRIP), to conduct research in a clinically evaluated cohort of individuals with SCD across their lifetime...
May 24, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29782390/suspecting-hyperferritinemic-sepsis-in-iron-deficient-population-do-we-need-a-lower-plasma-ferritin-threshold
#15
Swarup Ghosh, Arun K Baranwal, Prateek Bhatia, Karthi Nallasamy
OBJECTIVES: Hyperferritinemia is being suggested to identify patients with sepsis-induced macrophage activation syndrome for early intervention. However, data among iron-deficient children are scarce. This study was planned to explore the biological behavior of plasma ferritin in children from communities with a high frequency of iron deficiency with septic shock and its association with the outcome. DESIGN: Prospective observational study. SETTING: Tertiary care teaching hospital in a low-middle income economy of South Asia...
May 18, 2018: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29779995/factors-predicting-postoperative-febrile-urinary-tract-infection-following-percutaneous-nephrolithotomy-in-prepubertal-children
#16
Onur Kaygısız, Nihat Satar, Ali Güneş, Hasan Serkan Doğan, Ahmet Erözenci, Ender Özden, Mehmet Mesut Pişkin, Deniz Demirci, Serdar Toksöz, Tufan Çiçek, Serhat Gürocak, Hakan Kılıçarslan, Oktay Nazlı, Aykut Kefi, Volkan İzol, Ali Beytur, Şaban Sarıkaya, Serdar Tekgül, Bülent Önal
BACKGROUND: Predictive tables and scoring systems can predict stone clearance. However, there is a paucity of evidence regarding the prediction of complications during percutaneous nephrolithotomy (PCNL), particularly in children, which remains under-researched. To our knowledge, no studies have evaluated the risk factors for febrile urinary tract infection (FUTI) after pediatric PCNL. OBJECTIVES: To assess the predictive factors of FUTI in prepubertal children after PCNL and determine whether any prophylactic cephalosporins are superior for decreasing the FUTI rate...
May 5, 2018: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29778713/concluding-commentary-on-current-trends-to-enhance-the-clinical-safety-of-pediatric-transfusion-focusing-on-prevention-of-untoward-complications-of-hsc-transplantation-newer-strategies-for-improving-the-standards-of-safety-quality-of-stem-cells-expansion-for
#17
REVIEW
Irena Sniecinski, Jerard Seghatchian
Clinical practice and related diagnostic, development and research [DDR] strategies in pediatric transfusion and transplantation cover a broad range of multidisciplinary studies, performed by many professionals involved in this most challenging clinical field [1]. This commentary on the current position and future perspectives in pediatric transfusion field is aimed to highlight major unresolved transfusion complications in pediatric patients, namely red blood cell and platelet alloimmunisation, and new ones such as nosocomial infection, thrombosis and multi-organ failure...
May 16, 2018: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29773498/special-considerations-for-the-use-of-pathogen-reduced-blood-components-in-pediatric-patients-an-overview
#18
REVIEW
Raymond P Goodrich, Jerard Segatchian
Pediatric patients requiring transfusion constitute one of the most challenging areas of transfusion practice. Due to the limitations posed by their particular physiological conditions they routinely require specialized component support and more personalised transfusion care than what is routinely utilized in the care of adult patients. Pediatric patients, unlike many adult patients requiring transfusion support, also generally have significant lifespans post-transfusion. This combined with the possibility of long term consequences to adverse events related to transfusion such as infection or change in immunological status drives the need to continue to use improved blood components in the transfusion support of pediatric patients...
May 14, 2018: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29773497/indications-for-red-cell-transfusions-in-pediatric-patients
#19
REVIEW
Jill M Cholette, Suzie A Noronha, Jerard Seghatchian, Neil Blumberg
Red cell transfusions are amongst the most common therapeutic procedures in seriously ill children, particularly in the inpatient setting. This is despite the fact that there is no evidence base for most clinical settings, with the exception of patients with hemoglobinopathies, particularly thalassemia and sickle cell anemia. Obviously exsanguinating hemorrhage and life threatening anemia are urgent indications for which no other therapeutic approach is currently available. Most transfusions are, however, given prophylactically to prevent the complications of hypoxia or hemodynamic stability, based upon expert opinion and a faith in the oxygen carrying capacity and beneficial hemodynamic properties of transfused red cells...
May 10, 2018: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29770997/gemcitabine-nab-paclitaxel-for-pediatric-relapsed-refractory-sarcomas
#20
Jonathan L Metts, Adina L Alazraki, Dana Clark, Ernest K Amankwah, Karen J Wasilewski-Masker, Bradley A George, Thomas A Olson, Thomas Cash
BACKGROUND: Pediatric patients with relapsed/refractory sarcomas have poor outcomes and need novel therapies that provide disease control while maintaining an acceptable quality of life. The activity and toxicity of gemcitabine and nab-paclitaxel in combination has not been reported in pediatrics. PROCEDURE: We reviewed the records of fifteen relapsed/refractory patients and one treatment-naïve patient who received gemcitabine/nab-paclitaxel at our institution...
May 17, 2018: Pediatric Blood & Cancer
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